CN105497863A - Traditional Chinese medicine composition for treating acute mastitis - Google Patents

Traditional Chinese medicine composition for treating acute mastitis Download PDF

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Publication number
CN105497863A
CN105497863A CN201610077205.9A CN201610077205A CN105497863A CN 105497863 A CN105497863 A CN 105497863A CN 201610077205 A CN201610077205 A CN 201610077205A CN 105497863 A CN105497863 A CN 105497863A
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herba
radix
chinese medicine
powder
medicine composition
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不公告发明人
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Qingdao You Cheng New And High Technology Co Ltd
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Qingdao You Cheng New And High Technology Co Ltd
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
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Abstract

The invention relates to the field of traditional Chinese medicines, in particular to traditional Chinese medicine composition for treating acute mastitis. The traditional Chinese medicine composition is composed of Radix Salviae Miltiorrhizae, Myrrha, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae, Fructus Lycii, Radix Glycyrrhizae, Flos Lonicerae, Radix Puerariae, Lignum Dalbergiae Odoriferae, Folium Callicarpae Formosanae, Rhizoma Zingiberis Preparata, Spora Lygodii, Fructus Foeniculi, Olibanum, Radix Tripterygii Wilfordii, Herba Lycopodii, Radix Rehmanniae Preparata, Semen Celosiae Argenteae, Caulis Sargentodoxae, Bulbus Fritillariae Cirrhosae, Herba Elsholtziae, Herba portulacae and the like. According to the invention, the traditional Chinese medicine composition has a good efficacy for acute mastitis, and has the characteristics of short course, low cost, convenience for use and difficult recurrence. Based on a theoretical recipe of traditional Chinese medicine, the traditional Chinese medicine composition is reasonable in medicine selection, has the effects of soothing liver and regulating qi, clearing heat and detoxicating, promoting blood circulation and dispersing welling-abscesses, and achieves a purpose of treating acute mastitis. The medicine provided by the invention has the characteristics of rigorouscompatibility, mild medicine property and significant efficacy, and facilitates the clinical large-scale popularization and application.

Description

The Chinese medicine composition for the treatment of acute mastitis
Technical field
The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to the Chinese medicine composition for the treatment of acute mastitis.
Background technology
Acute mastitis is that the acute festering type of mammary gland infects, and be in lactiferous ducts and surrounding connective tissue inflammation, the multiple women being born in the postpartum breastfeeding phase, especially primipara is more common.Have that bibliographical information acute mastitis primipara is ill accounts for 50%, primipara is 2.4:1 with the ratio of multipara.Any time of age of sucking all can occur, but the most common with 3 ~ 4 weeks puerperal, therefore also known as puerperal mastitis.
The harm of mastitis is larger, from the beginning of time mammary swelling, pain, lump tenderness, surface is red and swollen, heating; As continued development, then exacerbation of symptoms, breast throbbing pain.Severe mastitis patient can with hyperpyrexia, shiver with cold, and breast swell and pain is obvious, and local skin is red and swollen, has scleroma, tenderness, the enlargement of Ipsilateral axillary lymph knot, tenderness.Inflammation is softening within a couple of days, forms galactapostema, has fluctuation, the skin rubefaction that abscess is dark and fluctuation not obvious.After ulceration comes to a head, pus drain is unobstructed, can swell disappear alleviation of pain and more acute mastitis often with the enlargement of Ipsilateral axillary gland, have tenderness; Total white blood cells and neutrophilic granulocyte number increase.After suffering from mastitis, if malpractice hazardness is just larger, abscess just likely wears out loose connective tissue before pectoralis major fascia, forms retromammary abscess; Or milk overflows from wound place and forms mammary fistula; Notably pyaemia septica can be there is.
At present, the treatment of acute mastitis mainly contains physiotherapy and antibiotherapy, and it is large that physiotherapy exists damage, requires high problem to treatment technology, and antibiotherapy side effect is large, particularly to the women being in age of sucking, is generally not suitable for using this method.Utilize Chinese herbal treatment, there is safe and effective advantage.
Summary of the invention
In order to overcome deficiency of the prior art, the invention provides the Chinese medicine composition for the treatment of acute mastitis, to acute mastitis, there is significant curative effect.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: the Chinese medicine composition for the treatment of acute mastitis, is made up of following component:
Radix Salviae Miltiorrhizae 1 ~ 20 part, Myrrha 1 ~ 20 part, 1 ~ 20 part, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae 1 ~ 20 part, Fructus Lycii 1 ~ 20 part, 1 ~ 20 part, Radix Glycyrrhizae, Flos Lonicerae 1 ~ 20 part, Radix Puerariae 1 ~ 20 part, Lignum Dalbergiae Odoriferae 1 ~ 20 part, Folium Callicarpae Formosanae 1 ~ 20 part, Rhizoma Zingiberis Preparatum 1 ~ 20 part, Spora Lygodii 1 ~ 20 part, Fructus Foeniculi 1 ~ 20 part, Olibanum 1 ~ 20 part, Radix Tripterygii Wilfordii 1 ~ 20 part, Herba Lycopodii 1 ~ 20 part, Radix Rehmanniae Preparata 1 ~ 20 part, Semen Celosiae 1 ~ 20 part, Caulis Sargentodoxae 1 ~ 20 part, Bulbus Fritillariae Cirrhosae 1 ~ 20 part, Herba Moslae 1 ~ 20 part, Herba Portulacae 1 ~ 20 part, Exocarpium Benincasae 1 ~ 20 part, Herba Siegesbeckiae 1 ~ 20 part, Herba Menthae 1 ~ 20 part, Spina Gleditsiae 1 ~ 20 part, Herba Lycopi 1 ~ 20 part, Herba Artemisiae Anomalae 1 ~ 20 part, Flos Chrysanthemi Indici 1 ~ 20 part, Herba Violae 1 ~ 20 part, Aloe 1 ~ 20 part, Fructus Chaenomelis 1 ~ 20 part.
As preferably, the present invention is made up of each component of following parts by weight:
Radix Salviae Miltiorrhizae 1 ~ 15 part, Myrrha 1 ~ 15 part, 1 ~ 15 part, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae 1 ~ 15 part, Fructus Lycii 1 ~ 15 part, 1 ~ 15 part, Radix Glycyrrhizae, Flos Lonicerae 1 ~ 15 part, Radix Puerariae 1 ~ 15 part, Lignum Dalbergiae Odoriferae 1 ~ 15 part, Folium Callicarpae Formosanae 1 ~ 15 part, Rhizoma Zingiberis Preparatum 1 ~ 15 part, Spora Lygodii 1 ~ 15 part, Fructus Foeniculi 1 ~ 15 part, Olibanum 1 ~ 15 part, Radix Tripterygii Wilfordii 1 ~ 15 part, Herba Lycopodii 1 ~ 15 part, Radix Rehmanniae Preparata 1 ~ 15 part, Semen Celosiae 1 ~ 15 part, Caulis Sargentodoxae 1 ~ 15 part, Bulbus Fritillariae Cirrhosae 1 ~ 15 part, Herba Moslae 1 ~ 15 part, Herba Portulacae 1 ~ 15 part, Exocarpium Benincasae 1 ~ 15 part, Herba Siegesbeckiae 1 ~ 15 part, Herba Menthae 1 ~ 15 part, Spina Gleditsiae 1 ~ 15 part, Herba Lycopi 1 ~ 15 part, Herba Artemisiae Anomalae 1 ~ 15 part, Flos Chrysanthemi Indici 1 ~ 15 part, Herba Violae 1 ~ 15 part, Aloe 1 ~ 15 part, Fructus Chaenomelis 1 ~ 15 part.
As preferably, the present invention is made up of each component of following parts by weight:
Radix Salviae Miltiorrhizae 1 ~ 10 part, Myrrha 1 ~ 10 part, 1 ~ 10 part, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae 1 ~ 10 part, Fructus Lycii 1 ~ 10 part, 1 ~ 10 part, Radix Glycyrrhizae, Flos Lonicerae 1 ~ 10 part, Radix Puerariae 1 ~ 10 part, Lignum Dalbergiae Odoriferae 1 ~ 10 part, Folium Callicarpae Formosanae 1 ~ 10 part, Rhizoma Zingiberis Preparatum 1 ~ 10 part, Spora Lygodii 1 ~ 10 part, Fructus Foeniculi 1 ~ 10 part, Olibanum 1 ~ 10 part, Radix Tripterygii Wilfordii 1 ~ 10 part, Herba Lycopodii 1 ~ 10 part, Radix Rehmanniae Preparata 1 ~ 10 part, Semen Celosiae 1 ~ 10 part, Caulis Sargentodoxae 1 ~ 10 part, Bulbus Fritillariae Cirrhosae 1 ~ 10 part, Herba Moslae 1 ~ 10 part, Herba Portulacae 1 ~ 10 part, Exocarpium Benincasae 1 ~ 10 part, Herba Siegesbeckiae 1 ~ 10 part, Herba Menthae 1 ~ 10 part, Spina Gleditsiae 1 ~ 10 part, Herba Lycopi 1 ~ 10 part, Herba Artemisiae Anomalae 1 ~ 10 part, Flos Chrysanthemi Indici 1 ~ 10 part, Herba Violae 1 ~ 10 part, Aloe 1 ~ 10 part, Fructus Chaenomelis 1 ~ 10 part.
The dosage form of Chinese medicine preparation of the present invention is: product for oral administration: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, plaster or syrup, and externally applied product is: patch, unguentum or spray.
As preferably, present invention also offers the preparation method of the Chinese medicine composition for the treatment of acute mastitis, its preparation comprises the following steps:
When described dosage form for oral administration is oral solutions, preparation method comprises:
A, get crude drug and put into dehydrated alcohol and soak, heat is extracted 3 times, and becoming extractum shape, is component 1;
B, medicinal residues water extraction 2 times, thickening filtration is extractum shape, is component 2;
C, above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution sterilizing, adds dextrin, and then vacuum freezing seals and get final product.
In described step a, get crude drug add in the ethanol of 2 times amount soak 5 hours, heating extraction 3 times, each 1 hour, remove supernatant, merge extractive liquid, 200 orders filter, then are the ultrafiltration post ultrafiltration of 10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.14 extractum, heating is concentrated into extractum shape, stand for standby use, becomes component 1.
In described step b, 2 times of water gagings put into by the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, extraction time is 1 hour, and 300 orders filter, then is the ultrafiltration post ultrafiltration of 1000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.14 extractum, heating is concentrated into extractum shape, stand for standby use, becomes component 2.
In described step c, above-mentioned two kinds of component extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 10k, adds dextrin, then vacuum canning sealing and get final product, and directly drinks during use.
As preferably, present invention also offers the preparation method of the Chinese medicine composition of acute mastitis, its preparation comprises the following steps:
The first step, by Radix Salviae Miltiorrhizae, Myrrha, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae, Fructus Lycii, Radix Glycyrrhizae, Flos Lonicerae, Radix Puerariae, Lignum Dalbergiae Odoriferae, Folium Callicarpae Formosanae, Rhizoma Zingiberis Preparatum, Spora Lygodii, Fructus Foeniculi, Olibanum, Radix Tripterygii Wilfordii, Herba Lycopodii, Radix Rehmanniae Preparata, Semen Celosiae, Caulis Sargentodoxae, Bulbus Fritillariae Cirrhosae, Herba Moslae, Herba Portulacae is ground into powder respectively, be mixed in proportion, load in percolator, adding relative to the determining alcohol of mixture quality 2 times is the ethanol of 95%, soak 12 hours at ambient temperature, open the valve of percolator, alcoholic solution slowly oozes, the speed of oozing is 0.5ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, removing alcoholic solution, dry, pulverize, obtain the first powder,
Second step, is mixed in proportion remaining components, adds the water relative to mixture quality 1 times, boil 1 hour, filter, obtain the first filtrate, filtering residue adds the water relative to 5 times, mixture again, again boils 3 hours, filters, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated, except anhydrating, dry, pulverize, obtain the second powder;
3rd step, by the first powder, the second powder mixing, adds corresponding adjuvant, obtains Chinese powder medicine.
As preferably, present invention also offers the another kind of preparation method of the Chinese medicine composition composition powders for the treatment of acute mastitis, its preparation comprises the following steps:
The first step, by Radix Salviae Miltiorrhizae, Myrrha, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae, Fructus Lycii, Radix Glycyrrhizae, Flos Lonicerae, Radix Puerariae, Lignum Dalbergiae Odoriferae, Folium Callicarpae Formosanae, Rhizoma Zingiberis Preparatum, Spora Lygodii, Fructus Foeniculi, Olibanum, Radix Tripterygii Wilfordii, Herba Lycopodii, Radix Rehmanniae Preparata, Semen Celosiae, Caulis Sargentodoxae, Bulbus Fritillariae Cirrhosae, Herba Moslae, Herba Portulacae is ground into powder respectively, be mixed in proportion, load in percolator, adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, soak 12 hours at ambient temperature, open the valve of percolator, alcoholic solution slowly oozes, the speed of oozing is 0.5ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, removing alcoholic solution, dry, pulverize, obtain the first powder,
Second step, remaining components is mixed in proportion, add 95% ethanol relative to mixture quality 3 times, boil 0.5 hour, filter, obtain the first filtrate, filtering residue adds relative to 2 times, mixture 95% again, again boil 0.5 hour, filter, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, with aperture at 100um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste also drying of 1.1 ~ 1.14, be ground into powder, obtain the second powder,
3rd step, by the first powder, the second powder mixing, adds corresponding adjuvant, obtains Chinese powder medicine.
Theoretical foundation of the present invention:
Radix Salviae Miltiorrhizae: nature and flavor: bitter, is slightly cold.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Myrrha: nature and flavor: bitter is flat.1. " property of medicine opinion ": " bitter in the mouth is pungent." 2. " Haiyao Bencao, Oversea Materia Medica ": " bitter in the mouth is pungent, temperature, nontoxic." 3. " Kaibao Bencao ": " bitter in the mouth is flat, nontoxic." return through: enter Liver Channel.1. " Bencao Jingshu ": " enter meridian of Foot-JUE YIN." 2. " book on Chinese herbal medicine is newly organized ": " enters spleen, kidney two warp." 3. " book on Chinese herbal medicine is looked for the truth ": " enters the heart, liver." function cures mainly: loose blood blood stasis removing, subduing swelling and relieving pain.Control and fall damage, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye, 1. " property of medicine opinion ": " Zhu is Daed E and damaged, and trusted subordinate's blood stasis, Shang Zhe Wei falls, muscles and bones stasis of blood pain, and golden sword damaged, unbearably painful, all with wine throwing drink." 2. " Haiyao Bencao, Oversea Materia Medica ": " main injured horse pendant, pushes away old putting newly, can give birth to good blood, grind rotten, be taken after mixing with liquid with hot wine.Induced abortion. trusted subordinate all pain and pheasant leaks hemorrhoid, puerperal abdominalgia with blood stasis, and should ball, loose middle clothes." 3. " Japan hanako materia medica ": " breaks crux stagnated blood, detumescence poison."
Pericarpium Citri Reticulatae Viride: nature and flavor: toil, tepor.1. " Bencao Tujing ": " bitter in the mouth." 2. " medicine origin ": " temperature, acrid in the mouth." curing mainly secret formula " cloud, cold in nature, bitter in the mouth.The pungent micro-acid of " 3. " about can cure mirror ": " bitter in the mouth." return through: enter liver, gallbladder meridian. 1. Li Gao: " foot faints the guiding drug of the moon, shaoyang channel." 2. Materia Medica of Decoction: " meridian of Foot-JUE YIN guiding drug, enters meridian of Hand-SHAO YANG again." 3. " Thunder God concocts property of medicine solution ": " enters liver, spleen two warp." 4. " book on Chinese herbal medicine is through separating ": " enters liver channel of foot-Jueyin, lung meridian, heart channel of Hand-Shaoyin." function cures mainly: soothing the liver dispelling the stagnated QI, eliminating stagnation expectorant.Control breast side of body gastralgia, hernia, food stagnation, swelling of the breast, nodule in the breast, chronic malaria addiction block.
Flos Rosae Rugosae: nature and flavor: sweet; Micro-hardship; Temperature; Nontoxic.Gui Jing: liver; Spleen channel.Function cures mainly: resolving depression of regulating the flow of vital energy; Regulating menstruation by adjusting the flow of blood.Chest and diaphragm caused by main depression of liver-QI is full vexed, and gastral cavity side of body distending pain, breast is done swollen, menoxenia, and dysentery is had loose bowels, leukorrhagia, traumatic injury carbuncle.
Fructus Lycii: nature and flavor: sweet is flat.1. " not Lu ": " be slightly cold, nontoxic." 2. " property of medicine opinion ": " sweet in the mouth is flat." 3. " Treatise on Dietetic Therapy ": " trembles with fear, nontoxic." return through: enter liver, kidney channel.1. " book on Chinese herbal medicine converges and says ": " enter few cloudy, the meridian of Foot-JUE YIN of foot." 2. " book on Chinese herbal medicine is through separating ": " enters kidney meridian, heart channel of Hand-Shaoyin." 3. " key medicine divides agent ": " enters liver, stomach two warp, double enter lung meridian." function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.
Radix Glycyrrhizae: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Flos Lonicerae: nature and flavor: sweet, cold.Gui Jing: return lung, the heart, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Radix Puerariae: nature and flavor: sweet, pungent, cool.Gui Jing: return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.
Lignum Dalbergiae Odoriferae: nature and flavor: pungent; Temperature; Nontoxic.Gui Jing: liver; Spleen; Lung; Heart channel.Function cures mainly: promoting blood circulation to remove blood stasis, and hemostasis analgesic therapy, sending down the abnormal ascending QI, wards off dirty.Main pain in chest and hypochondrium, traumatic injury, wound hemorrhage, and the vomiting stomachache of colic of cold type pain or foul internal resistance.
Folium Callicarpae Formosanae: nature and flavor: property is put down, and taste is micro-pungent, bitter.Function cures mainly: hemostasis and anti-inflammation, dissipating blood stasis for subsidence of swelling.For stomach and the expensive infections of duodenum is hemorrhage, traumatic hemorrhage, epistaxis, gingiva bleeding gingival hemorrhage, sprain swell and ache, suppurative skin ulcer, burn, influenza.
Rhizoma Zingiberis Preparatum: nature and flavor: pungent, hot.Gui Jing: return spleen, stomach, kidney, the heart, lung meridian.Function cures mainly: warming spleen and stomach for dispelling cold, warming the meridian for stopping bleeding.For Deficiency and coldness of spleen and stomach, stomachache is vomited and diarrhoea, and tell nosebleed metrorrhagia, yang deficiency is lost blood.
Spora Lygodii: nature and flavor: sweet light, cold.1. " product remittance essence is wanted ": " lightly seasoned, property is put down, nontoxic." 2. " detailed outline ": " is sweet, cold, nontoxic." return through: enter small intestinal, urinary bladder channel.1. " detailed outline ": " small intestinal, bladder blood system.It is few cloudy that " 2. " book on Chinese herbal medicine converges and says ": " enters foot, hands, meridian of Foot-TAI YANG." 3. " book on Chinese herbal medicine is new again ": " enters spleen, kidney two warp." function cures mainly: heat-clearing and toxic substances removing, relieving stranguria by diuresis.Control urinary tract infection, lithangiuria, nebulousurine, leucorrhea, hepatitis, oedema due to nephritis, laryngopharynx swelling and pain, mumps, enteritis, dysentery, skin eczema, herpes zoster.
Fructus Foeniculi: nature and flavor: pungent, temperature.Gui Jing: return liver,kidney,spleen, stomach warp.Function cures mainly: dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach.For colic of cold type stomachache, the testis swelling and hanging down of either of the testes, dysmenorrhea, few abdomen cold type of pain, abdominal distention, lack of appetite and vomiting, hydrocele of testis.Salt Fructus Foeniculi warming the kidney dispersing cold for relieving pain.For colic of cold type stomachache, the testis swelling and hanging down of either of the testes, through cold stomachache.
Olibanum: nature and flavor: arduous, temperature.1. " not Lu ": " tepor." 2. " Japan hanako materia medica ": " acrid in the mouth, heat, micro-poison." 3. Li Gao: " bitter in the mouth is pungent, heat." return through: enter the heart, liver, spleen channel.1. Zhu Zhenheng: " enter meridian of Hand-SHAO YIN.It is few cloudy that " 2. " Bencao Jingshu ": " enters lunar, the hands of foot, double enter meridian of Foot-JUE YIN." function cures mainly: regulating qi and activating blood, and analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Radix Tripterygii Wilfordii: nature and flavor: bitter; Pungent; Large poison.Gui Jing: the heart; Liver Channel.Function cures mainly: expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Reducing swelling and alleviating pain; Parasite killing detoxifies.Main classes rheumatic arthritis; Rheumatic arthritis; Glomerulonephritis; Nephrotic syndrome; Lupus erythematosus; Mouth xerophthalmia scheorma syndrome; Behcet disease; Eczema; Psoriasis; Leprosy; Scabies; Stubborn dermatitis.
Herba Lycopodii: nature and flavor: toil, temperature.1. supplement to the Herbal: " bitter in the mouth is pungent, temperature, nontoxic." 2. " book on Chinese herbal medicine asks former): " sweet puckery, flat." return through: " Traditional Chinese Medicine in Sichuan will ": " enters liver,spleen,kidney three warp." function cures mainly: expelling wind and cold, dehumidifying detumescence, relaxing muscles and tendons to promote blood circulation.Control anemofrigid-damp arthralgia, joint aches, skin numbness, tetraparesis, edema, traumatic injury.
Radix Rehmanniae Preparata: nature and flavor: sweet, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
Semen Celosiae: bitter in the mouth, is slightly cold, nontoxic.Main pathogen, heat in skin, wind scabies itching over the body, kills three worms, malignant boil scabies louse, and hemorrhoid are lost, bottom skin ulcer.Sub-name Semen Cassiae, treats blue-purple lips.A careless Artemisia, a luxuriant Artemisia.By life anus.March adopts stem and leaf, dries in the shade.
Caulis Sargentodoxae: bitter in the mouth, property is put down.Return large intestine, Liver Channel.Tool removing toxicity for eliminating carbuncles, promoting blood circulation and stopping pain, expelling wind and removing dampness, disinsection efficiency.Cure mainly acute appendicitis, dysentery, mastalgia, dysmenorrhea, amenorrhea, traumatic injury, rheumatic arthralgia, abdominal pain due to worm stagnation.
Bulbus Fritillariae Cirrhosae: nature and flavor: bitter, sweet, is slightly cold.Gui Jing: return lung, heart channel.Function cures mainly: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.
Herba Moslae: relieving the exterior syndrome by diaphoresis, removing dampness for regulating stomach, inducing diuresis to remove edema.Cure mainly: Xia Yue sense cold fluid-retention is cold, and have a headache and fever, aversion to cold is lossless, and the feeling of stuffiness in chest is suffered from abdominal pain, vomiting and diarrhoea, edema, beriberi.
Herba Portulacae: function cures mainly: heat-clearing and toxic substances removing, loose blood detumescence.Control hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, trace scrofula.For damp and hot caused diarrhoea, dysentery, often join Rhizoma Coptidis, the Radix Aucklandiae.Take orally or smash juice external application, controlling carbuncle.Also for having blood in stool, metrorrhagia, have anastalsis.
Exocarpium Benincasae: nature and flavor: sweet is cool.Gui Jing: return spleen, small intestine meridian.Function cures mainly: inducing diuresis to remove edema.For edema distension, dysuria, summer-heat is thirsty, oliguria with reddish urine.
Herba Siegesbeckiae: nature and flavor: pungent, bitter, cold.Gui Jing: return liver, kidney channel.Function cures mainly: wind-damp dispelling, sharp joint, removing toxic substances.For rheumatic arthralgia, muscles and bones is unable, soreness of the waist and knees, quadriplegia, hemiplegia, rubella eczema.
Herba Menthae: nature and flavor: pungent is cool.Gui Jing: return lung, Liver Channel.Function cures mainly: dispelling wind-heat.Refresh oneself, rash.For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast the side of body feeling of distension and oppression.
Spina Gleditsiae: nature and flavor: pungent, temperature.Gui Jing: return liver, stomach warp.Function cures mainly: detumescence poison holding, evacuation of pus, parasite killing.For carbuncle from the beginning of or difficulty in discharging of pus; External treatment scabies leprosy.
Herba Lycopi: nature and flavor: bitter, pungent, tepor.Gui Jing: return liver, spleen channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema.
Herba Artemisiae Anomalae: nature and flavor: bitter, temperature.1. Tang Materia Medica: " bitter in the mouth, temperature." 2. " Japan hanako materia medica ": " is nontoxic." return through: enter the heart, spleen channel.1. " Thunder God concocts property of medicine solution ": " enter the heart, lung two warp." 2. " book on Chinese herbal medicine is newly organized ": " enters the heart, spleen, urinary bladder channel." 3. " book on Chinese herbal medicine is new again ": " enters liver, kidney two warp." function cures mainly: removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Control amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.
Flos Chrysanthemi Indici: nature and flavor: toil is cool.1. " book on Chinese herbal medicine converges and says ": " bitter in the mouth is pungent, and gas is cool, slightly poisonous." 2. " Traditional Chinese Medicine in Sichuan will ": " cold nature, sweet-bitter flavor is nontoxic." return through: " book on Chinese herbal medicine is looked for the truth ": " enters lung, liver." function cures mainly: wind and heat dispersing, subduing swelling and detoxicating.Control anemopyretic cold, pneumonia, diphtheria, gastroenteritis: hypertension, furuncle, carbuncle, aphtha, erysipelas, eczema, epidemic blisters.
Herba Violae: nature and flavor: bitter, acrid, cold.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.For furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom
Aloe: nature and flavor: bitter, cold.Gui Jing: return liver, stomach, large intestine channel.Function cures mainly: removing heat from the liver, relieving constipation.For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis
Fructus Chaenomelis: nature and flavor: acid, temperature.Gui Jing: return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion of vomiting and diarrhoea, beriberi edema.
The Chinese medicine composition for the treatment of acute mastitis provided by the invention is pure Chinese medicinal preparation, has good curative effect to acute mastitis, has that the course for the treatment of is good, cost is low, easy to use, the feature that not easily recurs.The present invention, according to theory of Chinese medical science formula, selects effect that medicine is reasonable, have depressed liver-energy dispersing and QI regulating, heat-clearing and toxic substances removing, eliminating carbuncle of invigorating blood circulation, reaches the object for the treatment of acute mastitis.It is rigorous that medicine of the present invention has compatibility, mild in medicine property and, feature evident in efficacy, is convenient to large scale application clinically.
Detailed description of the invention
Acute mastitis of the present invention belongs to the sick category of acute mastitis, and acute mastitis name of disease early sees Jin Gehong work handbook of Prescription for Emergency.Have another name called Jealousy breast.This etiology and pathology is discussed in the work such as Sui's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases volume 40 acute mastitis is waited ", as said: " be the bright passages through which vital energy circulates of sun, have in newborn person from supraclavicular fossa, impairment caused by overstrain vim and vigour; its deficient pulse; space between skin and muscles is empty, cold visitor, in meridians, coldly fights in blood; then blood is puckery obstructed; its blood returns it again, and QI-mass is not fallen apart, therefore knot is polymerized to carbuncle.Carbuncle gas is not declared, and fights mutually with blood, then heat-dissipating, and intenseness of heat is taken advantage of in blood, and blood changes into pus; Also have because of milk accumulation, fight mutually, accumulate long-pending heat-dissipating with blood, knot gathers and lactogenesis carbuncle person." Song's " Shengji Zonglu " carbuncle door has again new discussion to the etiology and pathology of acute mastitis, as Jealousy Ruzhong is said after generation: " ... QI and blood is popular, then upper is milk, and lower is moon water, and sensible up and down, not normal degree is normal person.Should lead to fill in then for pain, what steam was taken advantage of again is then swollen.Hold back to it popular heap soil or fertilizer over and around the roots.If imbalance is controlled, then tie hard nucleation, health high fever, very then aversion to wind, by being acute mastitis.Depressed acute mastitis handed down through generations, be also Jealousy breast person this also." one, external evil poison, being invaded by exogenous pathogen, or baby sucks, implication blown, and evil poison enters breast by newborn network, a solidifying mutually and primary disease with strongly fragrant breast.Says as in " surgery card control pandect breast portion card control blow breast ": " contain newborn and sleep, steam severe stuffy nose in infant is blown into newborn hole, QI rising in reverse order curdling, swells by causing to tie for the son of breast, Kou Qi inflammation heat.
Below in conjunction with specific embodiment, the present invention is further elaborated.
A, get crude drug Radix Salviae Miltiorrhizae 1 part, Myrrha 2 parts, 2 parts, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae 2 parts, Fructus Lycii 1 part, 3 parts, Radix Glycyrrhizae, Flos Lonicerae 3 parts, Radix Puerariae 3 parts, Lignum Dalbergiae Odoriferae 3 parts, Folium Callicarpae Formosanae 2 parts, Rhizoma Zingiberis Preparatum 2 parts, Spora Lygodii 2 parts, Fructus Foeniculi 2 parts, Olibanum 3 parts, Radix Tripterygii Wilfordii 3 parts, Herba Lycopodii 3 parts, Radix Rehmanniae Preparata 2 parts, Semen Celosiae 1 part, Caulis Sargentodoxae 1 part, Bulbus Fritillariae Cirrhosae 2 parts, Herba Moslae 3 parts, Herba Portulacae 2 parts, Exocarpium Benincasae 2 parts, Herba Siegesbeckiae 3 parts, Herba Menthae 1 part, Spina Gleditsiae 3 parts, Herba Lycopi 3 parts, Herba Artemisiae Anomalae 3 parts, Flos Chrysanthemi Indici 2 parts, Herba Violae 3 parts, Aloe 3 parts, Fructus Chaenomelis 2 parts adds in the ethanol of 2 times amount to be soaked 5 hours, heating extraction 3 times, each 1 hour, remove supernatant, merge extractive liquid, 200 orders filter, be the ultrafiltration post ultrafiltration of 10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.14 extractum, heating is concentrated into extractum shape, stand for standby use, become component 1.
2 times of water gagings put into by b, the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, extraction time is 1 hour, 300 orders filter, be the ultrafiltration post ultrafiltration of 1000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.14 extractum, heating be concentrated into extractum shape, stand for standby use, becomes component 2;
C, above-mentioned two kinds of component extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 10k, adds dextrin, then vacuum canning sealing and get final product, and directly drinks during use.。
Embodiment 2
The present embodiment comprises following weight composition: Radix Salviae Miltiorrhizae 1 part, Myrrha 2 parts, 2 parts, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae 2 parts, Fructus Lycii 1 part, 3 parts, Radix Glycyrrhizae, Flos Lonicerae 3 parts, Radix Puerariae 3 parts, Lignum Dalbergiae Odoriferae 3 parts, Folium Callicarpae Formosanae 2 parts, Rhizoma Zingiberis Preparatum 2 parts, Spora Lygodii 2 parts, Fructus Foeniculi 2 parts, Olibanum 3 parts, Radix Tripterygii Wilfordii 3 parts, Herba Lycopodii 3 parts, Radix Rehmanniae Preparata 2 parts, Semen Celosiae 1 part, Caulis Sargentodoxae 1 part, Bulbus Fritillariae Cirrhosae 2 parts, Herba Moslae 3 parts, Herba Portulacae 2 parts, Exocarpium Benincasae 2 parts, Herba Siegesbeckiae 3 parts, Herba Menthae 1 part, Spina Gleditsiae 3 parts, Herba Lycopi 3 parts, Herba Artemisiae Anomalae 3 parts, Flos Chrysanthemi Indici 2 parts, Herba Violae 3 parts, Aloe 3 parts, Fructus Chaenomelis 2 parts.
Its preparation comprises the following steps:
The first step, by Radix Salviae Miltiorrhizae, Myrrha, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae, Fructus Lycii, Radix Glycyrrhizae, Flos Lonicerae, Radix Puerariae, Lignum Dalbergiae Odoriferae, Folium Callicarpae Formosanae, Rhizoma Zingiberis Preparatum, Spora Lygodii, Fructus Foeniculi, Olibanum, Radix Tripterygii Wilfordii, Herba Lycopodii, Radix Rehmanniae Preparata, Semen Celosiae, Caulis Sargentodoxae, Bulbus Fritillariae Cirrhosae, Herba Moslae, Herba Portulacae is ground into powder respectively, be mixed in proportion, load in percolator, adding relative to the determining alcohol of mixture quality 2 times is the ethanol of 95%, soak 12 hours at ambient temperature, open the valve of percolator, alcoholic solution slowly oozes, the speed of oozing is 0.5ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, removing alcoholic solution, dry, pulverize, obtain the first powder,
Second step, is mixed in proportion remaining components, adds the water relative to mixture quality 1 times, boil 1 hour, filter, obtain the first filtrate, filtering residue adds the water relative to 5 times, mixture again, again boils 3 hours, filters, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated, except anhydrating, dry, pulverize, obtain the second powder;
3rd step, by the first powder, the second powder mixing, adds corresponding adjuvant, obtains Chinese powder medicine.
Embodiment 3
The present embodiment comprises following weight composition: Radix Salviae Miltiorrhizae 1 part, Myrrha 2 parts, 2 parts, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae 2 parts, Fructus Lycii 1 part, 3 parts, Radix Glycyrrhizae, Flos Lonicerae 3 parts, Radix Puerariae 3 parts, Lignum Dalbergiae Odoriferae 3 parts, Folium Callicarpae Formosanae 2 parts, Rhizoma Zingiberis Preparatum 2 parts, Spora Lygodii 2 parts, Fructus Foeniculi 2 parts, Olibanum 3 parts, Radix Tripterygii Wilfordii 3 parts, Herba Lycopodii 3 parts, Radix Rehmanniae Preparata 2 parts, Semen Celosiae 1 part, Caulis Sargentodoxae 1 part, Bulbus Fritillariae Cirrhosae 2 parts, Herba Moslae 3 parts, Herba Portulacae 2 parts, Exocarpium Benincasae 2 parts, Herba Siegesbeckiae 3 parts, Herba Menthae 1 part, Spina Gleditsiae 3 parts, Herba Lycopi 3 parts, Herba Artemisiae Anomalae 3 parts, Flos Chrysanthemi Indici 2 parts, Herba Violae 3 parts, Aloe 3 parts, Fructus Chaenomelis 2 parts.
Its preparation comprises the following steps:
The first step, by Radix Salviae Miltiorrhizae, Myrrha, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae, Fructus Lycii, Radix Glycyrrhizae, Flos Lonicerae, Radix Puerariae, Lignum Dalbergiae Odoriferae, Folium Callicarpae Formosanae, Rhizoma Zingiberis Preparatum, Spora Lygodii, Fructus Foeniculi, Olibanum, Radix Tripterygii Wilfordii, Herba Lycopodii, Radix Rehmanniae Preparata, Semen Celosiae, Caulis Sargentodoxae, Bulbus Fritillariae Cirrhosae, Herba Moslae, Herba Portulacae is ground into powder respectively, be mixed in proportion, load in percolator, adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, soak 12 hours at ambient temperature, open the valve of percolator, alcoholic solution slowly oozes, the speed of oozing is 0.5ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, removing alcoholic solution, dry, pulverize, obtain the first powder,
Second step, remaining components is mixed in proportion, add 95% ethanol relative to mixture quality 3 times, boil 0.5 hour, filter, obtain the first filtrate, filtering residue adds relative to 2 times, mixture 95% again, again boil 0.5 hour, filter, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, with aperture at 100um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste also drying of 1.1 ~ 1.14, be ground into powder, obtain the second powder,
3rd step, by the first powder, the second powder mixing, adds corresponding adjuvant, obtains Chinese powder medicine.
Toxicity test:
Laboratory animal
White mice is provided by Qingdao City's laboratory animal and animal experimental center.
Mice lavage administration acute toxicity testing
Get healthy mice 32, male and female half and half, within 24 hours, divide three groups, only, gross weight 1.8ml, is equivalent to crude drug in whole 4.0g to each 0.6ml/ of gavage intestinal, i.e. 10g crude drug/kg/d, is equivalent to 857 times of clinical 65 kilograms of people.After mice administration routinely feedstuff within 12 days, have no animal dead and do not go out, existing toxic reaction.Therefore prove, medicine of the present invention has no side effect, and clinical practice is safe and reliable.
Rat oral gavage administration long term toxicity test
Toxicity test:
Healthy rat Wistar, body weight 10-130g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and all death in 12 days is observed in remaining 1/2 drug withdrawal.
Test rat body weight, diet, emotion, movable energy.Hemogram checking red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counts.Biochemical analysis: serum albumin is quantitative, cholesterol, blood sugar quantitative.Pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.
Experimental result represents: medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Chinese medicine preparation long-term prescription of the present invention is showed no obvious toxic action to whole body important organ.Result of the test shows: Chinese medicine preparation experiment safety of the present invention.
Clinical trial
1, general clinical data 237 example is my institute Breast Clinic patient of in March, 2010 ~ 2016 year January, is divided into two groups at random.Treatment group 119 example, matched group 118 example.Two groups of above-mentioned data compare without significant difference (P > 0.05), have comparability.
2, formulate about the diagnosis basis of acutemastitis in diagnostic criteria is promulgated with reference to State Administration of Traditional Chinese Medicine " Chinese medicine Illnesses Diagnoses criterion of therapeutical effect " (zy/100.2-94).Get rid of chronic mastitis, plasma cell mastitis, fat necrosis of breast, inflammatory breast cancer etc.
3, Therapeutic Method treatment group takes embodiment 1 potion every day of the present invention agent, divides early, late secondary is taken, and within 7 days, is 1 course for the treatment of.Matched group: adopting Cefuroxime Sodium 110g to add normal saline 20mL intravenous injection, every day 2 times, 7 days is a course for the treatment of.
4, criterion of therapeutical effect: judge curative effect with reference to " clinical disease diagnosis cures improvement standard " [2].1. cure: General Symptoms and local symptom, sign disappear completely; 2. effective: General Symptoms disappears, breast local still has lump; 3. invalid: General Symptoms increases the weight of, breast local red and swollen heat pain is obvious, has tendency of suppurating.
5, therapeutic outcome two groups of comparitive study, are better than matched group (P > 0.05) in table 1. result display treatment group curative effect
Table 1 liang group comparitive study n (%)
Two groups of clinical symptoms and sign improvement are compared in table 2.Result show two groups through treatment after mastalgia scoring and lump in breast comparatively treat before obviously improve (P < 0.05 or 0.01), and treatment group improve degree be better than matched group (P < 0.05).
Treat front and back with this group to compare, * P < 0.05, * * P < 0.01; Compare with after treatment of control group, △ P < 0.05.
Model case:
(1), Liu so-and-so, the 10th day puerperal, bilateral mammary swelling pain, human milk silt lump; With fever with aversion to cold, headache, aching of the whole body etc.; Yellow fur, rapid pulse, is diagnosed as acute mastitis; Take Chinese medicine composition of the present invention to take a turn for the better after 1 day, take recovery from illness in 3 days.
(2), Jiang, there is mammary swelling pain in one week puerperal, is acute mastitis after diagnosing; Take Chinese medicine composition of the present invention to take a turn for the better after 2 days, take recovery from illness in 5 days.
(3), Lee so-and-so, puerperal 14 fever with aversion to cold, general malaise, left breast swelling pain.Look into, body temperature 38.7 °, the red and swollen area 8310cm of left breast, surface burns, comparatively hard, tenderness is obvious, and in April, 2011 examines my institute, examines as acute mastitis, fully recovers after giving a course for the treatment of of traditional Chinese medicine composition for treating of the present invention.
(3), Liu so-and-so, right breast has the large lump of an egg, in throbbing pain, companion's fever with aversion to cold 2 days, 2 examine as acute mastitis, and after giving a course for the treatment of of traditional Chinese medicine composition for treating of the present invention, symptom all disappears.
The above; it is only most preferred embodiment of the present invention; not any pro forma restriction is done to the present invention; any those of ordinary skill in the art; do not departing under technical solution of the present invention ambit; utilize the method content of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, all belong to the scope of claims protection.

Claims (10)

1. treat the Chinese medicine composition of acute mastitis, it is characterized in that: be made up of following component:
Radix Salviae Miltiorrhizae 1 ~ 20 part, Myrrha 1 ~ 20 part, 1 ~ 20 part, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae 1 ~ 20 part, Fructus Lycii 1 ~ 20 part, 1 ~ 20 part, Radix Glycyrrhizae, Flos Lonicerae 1 ~ 20 part, Radix Puerariae 1 ~ 20 part, Lignum Dalbergiae Odoriferae 1 ~ 20 part, Folium Callicarpae Formosanae 1 ~ 20 part, Rhizoma Zingiberis Preparatum 1 ~ 20 part, Spora Lygodii 1 ~ 20 part, Fructus Foeniculi 1 ~ 20 part, Olibanum 1 ~ 20 part, Radix Tripterygii Wilfordii 1 ~ 20 part, Herba Lycopodii 1 ~ 20 part, Radix Rehmanniae Preparata 1 ~ 20 part, Semen Celosiae 1 ~ 20 part, Caulis Sargentodoxae 1 ~ 20 part, Bulbus Fritillariae Cirrhosae 1 ~ 20 part, Herba Moslae 1 ~ 20 part, Herba Portulacae 1 ~ 20 part, Exocarpium Benincasae 1 ~ 20 part, Herba Siegesbeckiae 1 ~ 20 part, Herba Menthae 1 ~ 20 part, Spina Gleditsiae 1 ~ 20 part, Herba Lycopi 1 ~ 20 part, Herba Artemisiae Anomalae 1 ~ 20 part, Flos Chrysanthemi Indici 1 ~ 20 part, Herba Violae 1 ~ 20 part, Aloe 1 ~ 20 part, Fructus Chaenomelis 1 ~ 20 part.
2. the Chinese medicine composition for the treatment of acute mastitis according to claim 1, is characterized in that: be made up of each component of following parts by weight:
Radix Salviae Miltiorrhizae 1 ~ 15 part, Myrrha 1 ~ 15 part, 1 ~ 15 part, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae 1 ~ 15 part, Fructus Lycii 1 ~ 15 part, 1 ~ 15 part, Radix Glycyrrhizae, Flos Lonicerae 1 ~ 15 part, Radix Puerariae 1 ~ 15 part, Lignum Dalbergiae Odoriferae 1 ~ 15 part, Folium Callicarpae Formosanae 1 ~ 15 part, Rhizoma Zingiberis Preparatum 1 ~ 15 part, Spora Lygodii 1 ~ 15 part, Fructus Foeniculi 1 ~ 15 part, Olibanum 1 ~ 15 part, Radix Tripterygii Wilfordii 1 ~ 15 part, Herba Lycopodii 1 ~ 15 part, Radix Rehmanniae Preparata 1 ~ 15 part, Semen Celosiae 1 ~ 15 part, Caulis Sargentodoxae 1 ~ 15 part, Bulbus Fritillariae Cirrhosae 1 ~ 15 part, Herba Moslae 1 ~ 15 part, Herba Portulacae 1 ~ 15 part, Exocarpium Benincasae 1 ~ 15 part, Herba Siegesbeckiae 1 ~ 15 part, Herba Menthae 1 ~ 15 part, Spina Gleditsiae 1 ~ 15 part, Herba Lycopi 1 ~ 15 part, Herba Artemisiae Anomalae 1 ~ 15 part, Flos Chrysanthemi Indici 1 ~ 15 part, Herba Violae 1 ~ 15 part, Aloe 1 ~ 15 part, Fructus Chaenomelis 1 ~ 15 part.
3. according to the Chinese medicine composition of the treatment acute mastitis described in claim 1 to 2, it is characterized in that: be made up of each component of following parts by weight:
Radix Salviae Miltiorrhizae 1 ~ 10 part, Myrrha 1 ~ 10 part, 1 ~ 10 part, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae 1 ~ 10 part, Fructus Lycii 1 ~ 10 part, 1 ~ 10 part, Radix Glycyrrhizae, Flos Lonicerae 1 ~ 10 part, Radix Puerariae 1 ~ 10 part, Lignum Dalbergiae Odoriferae 1 ~ 10 part, Folium Callicarpae Formosanae 1 ~ 10 part, Rhizoma Zingiberis Preparatum 1 ~ 10 part, Spora Lygodii 1 ~ 10 part, Fructus Foeniculi 1 ~ 10 part, Olibanum 1 ~ 10 part, Radix Tripterygii Wilfordii 1 ~ 10 part, Herba Lycopodii 1 ~ 10 part, Radix Rehmanniae Preparata 1 ~ 10 part, Semen Celosiae 1 ~ 10 part, Caulis Sargentodoxae 1 ~ 10 part, Bulbus Fritillariae Cirrhosae 1 ~ 10 part, Herba Moslae 1 ~ 10 part, Herba Portulacae 1 ~ 10 part, Exocarpium Benincasae 1 ~ 10 part, Herba Siegesbeckiae 1 ~ 10 part, Herba Menthae 1 ~ 10 part, Spina Gleditsiae 1 ~ 10 part, Herba Lycopi 1 ~ 10 part, Herba Artemisiae Anomalae 1 ~ 10 part, Flos Chrysanthemi Indici 1 ~ 10 part, Herba Violae 1 ~ 10 part, Aloe 1 ~ 10 part, Fructus Chaenomelis 1 ~ 10 part.
4. the Chinese medicine composition of the treatment acute mastitis according to claims 1 to 3, it is characterized in that: product for oral administration: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, plaster or syrup, externally applied product is: patch, unguentum or spray.
5. the Chinese medicine composition of the treatment acute mastitis according to Claims 1-4, is characterized in that: when described dosage form for oral administration is oral solutions, preparation method comprises:
A, get crude drug and put into dehydrated alcohol and soak, heat is extracted 3 times, and becoming extractum shape, is component 1;
B, medicinal residues water extraction 2 times, thickening filtration is extractum shape, is component 2;
C, above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution sterilizing, adds dextrin, and then vacuum freezing seals and get final product.
6. the preparation method of the Chinese medicine composition for the treatment of acute mastitis according to claim 5, is characterized in that: in described step a, get crude drug add in the ethanol of 2 times amount soak 5 hours, heating extraction 3 times, each 1 hour, remove supernatant, merge extractive liquid, 200 orders filter, be the ultrafiltration post ultrafiltration of 10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.14 extractum, heating be concentrated into extractum shape, stand for standby use, becomes component 1.
7. the preparation method of the Chinese medicine composition for the treatment of acute mastitis according to claim 5, it is characterized in that: in described step b, 2 times of water gagings put into by the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, and extraction time is 1 hour, 300 orders filter, be the ultrafiltration post ultrafiltration of 1000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.14 extractum, heating be concentrated into extractum shape, stand for standby use, becomes component 2.
8. the preparation method of the Chinese medicine composition for the treatment of acute mastitis according to claim 5, it is characterized in that: in described step c, above-mentioned two kinds of component extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 10k, add dextrin, then vacuum canning sealing and get final product, directly drink during use.
9. the Chinese medicine composition of the treatment acute mastitis according to Claims 1-4, is characterized in that: when described dosage form for oral administration is powder, preparation method comprises:
The first step, by Radix Salviae Miltiorrhizae, Myrrha, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae, Fructus Lycii, Radix Glycyrrhizae, Flos Lonicerae, Radix Puerariae, Lignum Dalbergiae Odoriferae, Folium Callicarpae Formosanae, Rhizoma Zingiberis Preparatum, Spora Lygodii, Fructus Foeniculi, Olibanum, Radix Tripterygii Wilfordii, Herba Lycopodii, Radix Rehmanniae Preparata, Semen Celosiae, Caulis Sargentodoxae, Bulbus Fritillariae Cirrhosae, Herba Moslae, Herba Portulacae is ground into powder respectively, be mixed in proportion, load in percolator, adding relative to the determining alcohol of mixture quality 2 times is the ethanol of 95%, soak 12 hours at ambient temperature, open the valve of percolator, alcoholic solution slowly oozes, the speed of oozing is 0.5ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, removing alcoholic solution, dry, pulverize, obtain the first powder,
Second step, is mixed in proportion remaining components, adds the water relative to mixture quality 1 times, boil 1 hour, filter, obtain the first filtrate, filtering residue adds the water relative to 5 times, mixture again, again boils 3 hours, filters, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated, except anhydrating, dry, pulverize, obtain the second powder;
3rd step, by the first powder, the second powder mixing, adds corresponding adjuvant, obtains Chinese powder medicine.
10. according to the Chinese medicine composition of the treatment acute mastitis described in claim 1 to 9, it is characterized in that: when described dosage form for oral administration is powder, preparation method comprises:
The first step, by Radix Salviae Miltiorrhizae, Myrrha, Pericarpium Citri Reticulatae Viride, Flos Rosae Rugosae, Fructus Lycii, Radix Glycyrrhizae, Flos Lonicerae, Radix Puerariae, Lignum Dalbergiae Odoriferae, Folium Callicarpae Formosanae, Rhizoma Zingiberis Preparatum, Spora Lygodii, Fructus Foeniculi, Olibanum, Radix Tripterygii Wilfordii, Herba Lycopodii, Radix Rehmanniae Preparata, Semen Celosiae, Caulis Sargentodoxae, Bulbus Fritillariae Cirrhosae, Herba Moslae, Herba Portulacae is ground into powder respectively, be mixed in proportion, load in percolator, adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, soak 12 hours at ambient temperature, open the valve of percolator, alcoholic solution slowly oozes, the speed of oozing is 0.5ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, removing alcoholic solution, dry, pulverize, obtain the first powder,
Second step, remaining components is mixed in proportion, add 95% ethanol relative to mixture quality 3 times, boil 0.5 hour, filter, obtain the first filtrate, filtering residue adds relative to 2 times, mixture 95% again, again boil 0.5 hour, filter, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, with aperture at 100um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste also drying of 1.1 ~ 1.14, be ground into powder, obtain the second powder,
3rd step, by the first powder, the second powder mixing, adds corresponding adjuvant, obtains Chinese powder medicine.
CN201610077205.9A 2016-02-04 2016-02-04 Traditional Chinese medicine composition for treating acute mastitis Withdrawn CN105497863A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106267119A (en) * 2016-08-08 2017-01-04 青岛友诚高新技术有限公司 The Chinese medicine composition for the treatment of jaundice

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CN102670878A (en) * 2012-05-04 2012-09-19 刘超 Traditional Chinese medicine decoction for treating acute mastitis
CN103169881A (en) * 2012-12-28 2013-06-26 青岛华仁信息技术开发有限公司 Chinese medicament health product for supplementing female hormone for women during menopause and preparation method thereof
CN103385999A (en) * 2013-08-01 2013-11-13 刘建飞 Chinese medicine composition for treating acute mastitis
CN103638159A (en) * 2013-11-26 2014-03-19 宋爱民 External use traditional Chinese medicine preparation for treating acute mastitis

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102670878A (en) * 2012-05-04 2012-09-19 刘超 Traditional Chinese medicine decoction for treating acute mastitis
CN103169881A (en) * 2012-12-28 2013-06-26 青岛华仁信息技术开发有限公司 Chinese medicament health product for supplementing female hormone for women during menopause and preparation method thereof
CN103385999A (en) * 2013-08-01 2013-11-13 刘建飞 Chinese medicine composition for treating acute mastitis
CN103638159A (en) * 2013-11-26 2014-03-19 宋爱民 External use traditional Chinese medicine preparation for treating acute mastitis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106267119A (en) * 2016-08-08 2017-01-04 青岛友诚高新技术有限公司 The Chinese medicine composition for the treatment of jaundice

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Application publication date: 20160420