CN105476886A - Post-basking repairing composition and preparation method thereof - Google Patents
Post-basking repairing composition and preparation method thereof Download PDFInfo
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- CN105476886A CN105476886A CN201510868359.5A CN201510868359A CN105476886A CN 105476886 A CN105476886 A CN 105476886A CN 201510868359 A CN201510868359 A CN 201510868359A CN 105476886 A CN105476886 A CN 105476886A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Abstract
The invention discloses a post-basking repairing composition and a preparation method thereof. The post-basking repairing composition contains 0.01-0.20% of water-soluble eggshell membrane polypeptide, 0.50-4.00% of Alps glacial water, 0.50-2.00% of tocopheryl acetate, 0.10-0.25% of menthyl lactate and 1.00-4.00% of beta-glucan. The post-basking repairing composition is obtained by compounding the above ingredients and is capable of suiting the remedy to various problems of the post-basking skin and comprehensively repairing cells injured by ultraviolet irradiation. Through compounding of the above ingredients, using the post-basking repairing composition is like wrapping a thin layer of eggshell membrane on the fragile post-basking skin, so that the injured skin is protected and restored to the moisturized and glossy state. The post-basking repairing composition can make a user free from allergic reaction and is safe to use and remarkable in post-basking repairing effect.
Description
[technical field]
The present invention relates to rear remediation composition capable of a kind of solarization and preparation method thereof, belong to Cosmetic Manufacture technical field.
[background technology]
Summer is scorching, even if carry out tight sun-proof work, also cannot avoid the injury of sunlight completely, and burning blazing sun always leaves dark or shallow vestige on the human skin.After skin is subject to ultraviolet irradiation, can produces a large amount of oxonium ion free radicals, cause a series of photochemical reaction, cause skin hydropenia, produce erythema, barrier function is also damaged, and skin becomes more responsive.Fortunately, after ultraviolet radiation, must just can send out change celliferous through the incubation period of 6-8h and occur symptom, after shining, 6-8h repairs the phase also referred to as the gold after solarization, if can repair in the phase at gold and give the correct maintenance mode of skin, free radical in timely elimination skin also in time supplements skin moisture, can greatly reduce skin erythema index, avoid skin because of Exposure to Sunlight exsiccation blackening even aging.
Existing after-sun restorative product major part only focuses on the moisturizing of skin, and have ignored the elimination to oxonium ion free radical, really can not reach the reparation of skin after shining.And some product deflection shines rear skin-whitening, add white-skinned face function composition in the product, and these functional components easily cause stimulation even irritated to skin responsive after Exposure to Sunlight, not only could not reach the reparation of skin after shining, even may cause the further damage of skin.Market lacks a kind of skin care item carrying out comprehensively repairing for impaired skin after solarization.
[summary of the invention]
The object of the invention is to overcome the deficiencies in the prior art, for the various situations of skin after shining, provide a kind of more comprehensively, fast, remediation composition capable effectively and after the solarization of safety.
The present invention to achieve these goals, by the following technical solutions:
Remediation composition capable after a kind of solarization, repair component A phase after it is characterized in that the solarization containing following percentage by weight:
The percentage by weight of each component is for radix with remediation composition capable system total amount after whole solarization above.
Water-soluble eggshell membrane polypeptide: there is magical repairing regenerating ability.Egg film, the thin film of 0.07 millimeter, the divinity but can vouchsafed with the Nature is meticulously takeed good care of 1 cell for 21 days and is become 10,000,000,000, and be finally born a fresh and alive life.Main component is protein, close to the skin of the mankind and the composition of hair, is made up of 18 seed amino acids.Because containing the rigid albumen such as keratin, collagen protein in egg shell membrane, be filamentary structure, water insoluble, not by general protease hydrolyzed, be difficult to directly absorbed by the body.Just can be absorbed and used after these insoluble macromole scleroproteins are only hydrolyzed into small-molecule peptide and aminoacid, meet the needs of each histoorgan, improve human body to the effective rate of utilization of nutrient substance.Egg shell membrane is hydrolyzed into micromolecule polypeptide about 8000 dalton and eggshell membrane polypeptide with special process.Eggshell membrane polypeptide is made up of tropoelastin, desmosine, aminopolysaccharide, transforming growth factor-β four kinds of active component, wherein tropoelastin has the effect maintaining tissue, skin and blood vessel elasticity, desmosine can maintain skin and blood vessel elasticity, aminopolysaccharide can promote that cytothesis maintains tissue health, transform, growth factor-beta can promote cell proliferation and differentiation.By the combined effect of above several active component, for shining rear impaired cell Implantation Energy, giving cell unlimited vigor, promoting the metabolism of skin, strengthen circulation, reach the object of reparative regeneration.
Water-soluble eggshell membrane polypeptide in the present invention, accounts for 0.01-0.15% in total composition; Water-soluble eggshell membrane polypeptide in the present invention, accounts for 0.01-0.10% in total composition; Water-soluble eggshell membrane polypeptide in the present invention, accounts for 0.01-0.05% in total composition; Water-soluble eggshell membrane polypeptide in the present invention, accounts for 0.05-0.20% in total composition; Water-soluble eggshell membrane polypeptide in the present invention, accounts for 0.10-0.20% in total composition, and the water-soluble eggshell membrane polypeptide in the present invention, accounts for 0.15-0.20% in total composition.
Alps glacial water: can effectively moisturizing.Alps is European maximum mountainous villas center.Each drips glacial water and breeds For hundreds of millions of years on stratum, and experience more than 50 year Minerals And Rocks and filter, constantly gush out with fixing flow velocity and steady temperature, mineral content ratio is very applicable to human body requirements, is the water that a applicable skin is drunk; There is positive effect to human metabolism, cells multiply, skin water circulation channel can be opened, trace element supplement, allow skin while the pure pure and fresh environment of enjoyment, carry back and obtain water replenishment by skin.
Tocopherol acetas: can powerful scavenging free radicals.After skin is subject to ultraviolet irradiation, can produce a large amount of oxonium ion free radicals, too much reactive oxygen free radical just has vandalism, causes the damage of human normal cell and tissue, thus causes various diseases.Tocopherol acetas as natural antioxidant can with oxygen-derived free radicals generation redox reaction, oxygen-derived free radicals is thoroughly removed.
Beta glucan, the immunologic function of repair cell.The Active Defending System Against of skin is that (be called for short langerhans cell, langerhans cell is a kind of jejune dendron shape, contains the granule being referred to as Birbeck granule of a large amount of column or racket shape in endochylema with langerhans cells.When one piece of skin is infected, local langerhans cell will identify, catch and process microbial antigen, then move to the T lymphocyte region of the cortex of draining lymph node, and maturation become professional antigen presenting cells.If langerhans cell is impaired, the normal immunocompetence of skin will be affected.) be the tight network structure that dominant shape becomes, the antigen of intrusion, once cell, touches langerhans cell, will be engulfed and partial digested by it.Simultaneously langerhans cell also can activating immune system, thus is thoroughly removed by antigen.Due to the irradiation of UVB, the network that langerhans cell is formed starts to start a leak, and this makes antigen be able to transdermal, and the ability that skin removes antigen suffers damage, and causes existing collagen protein, elastin laminin, Dan Baiduotang proteoglycan PG to be constantly damaged.Use beta glucan can activate the such macrophage of langerhans cell, thus strengthen the function of human immune system.The langerhans cell be activated can secrete some factors, promotes the synthesis of fibroblastic propagation and skin histology mechanism (as collagen protein, elastin laminin, Dan Baiduotang proteoglycan PG and other component), skin elasticity is increased, soft delicate.
Beta glucan in the present invention, accounts for 1.0-4.0% in total composition; Beta glucan in the present invention, accounts for 1.5-4.0% in total composition; Beta glucan in the present invention, accounts for 2.0-4.0% in total composition; Beta glucan in the present invention, accounts for 2.5-4.0% in total composition; Beta glucan in the present invention, accounts for 3.0-4.0% in total composition; Beta glucan in the present invention, accounts for 3.5-4.0% in total composition; Beta glucan in the present invention, accounts for 0.5-3.5% in total composition; Beta glucan in the present invention, accounts for 0.5-3.0% in total composition; Beta glucan in the present invention, accounts for 0.5-2.5% in total composition; Beta glucan in the present invention, accounts for 0.5-2.0% in total composition; Beta glucan in the present invention, accounts for 0.5-1.5% in total composition; Beta glucan in the present invention, accounts for 0.5-1.0% in total composition; Beta glucan in the present invention, accounts for 1.0-3.5% in total composition; Beta glucan in the present invention, accounts for 1.5-3.0% in total composition; Beta glucan in the present invention, accounts for 2.0-3.5% in total composition.
Menthyl lactate is as the coolant of skin, and the permanent cooling effect of its uniqueness, can reduce Exposure to Sunlight skin surface temperature 3-6 degree, effective calm skin, alleviate scorching erythralgia phenomenon at once.
The present invention shines composite by above several component of rear reparation component, suits the remedy to the case, repair the cell suffering ultraviolet radiation impaired comprehensively for the various problems of skin after shining.Menthyl lactate can effective Lavender Extract, alleviates erythralgia at once; Alps glacial water effectively supplements the moisture scattered and disappeared, and opens skin water circulation channel; The powerful scavenging free radicals of tocopherol acetas, prevents skin photoaging; Beta glucan can activate langerhans cell, thus strengthen the function of human immune system, promote the synthesis of fibroblastic propagation and skin histology mechanism (as collagen protein, elastin laminin, Dan Baiduotang proteoglycan PG and other component), make skin again recover elasticity; Eggshell membrane polypeptide can, for shining rear impaired cell Implantation Energy, make Skin Cell refill vigor, gloss of getting well.Composite by several composition, just as give shine after fragile skin wrap very thin one deck egg film, protect impaired skin and to make it again recover water profit glossy.
The present invention shines rear remediation composition capable and also comprises oil phase component 9.5-20%, adjuvant component 0.5%, and triethanolamine adjust ph is to 5.0-7.0, and water phase components surplus, wherein contains glycerol 6.0-8.0% in water phase components.
Because tocopherol acetas in said composition is oil-soluble, therefore said composition is applicable to emulsification system, and is not suitable for transparent pure water agent system.Need to add glycerol in formula and shine menthyl lactate in rear remediation composition capable for dispersing and dissolving the present invention.
The percentage by weight of each component is for radix with remediation composition capable system total amount after whole solarization above.
The present invention shines rear preparation method of repairing combination, it is characterized in that comprising the following steps:
A, the tocopherol acetas repaired after shining in component and oil phase component are mixed and are warmed up to 80 DEG C, stirring and dissolving is complete;
B, reserved glycerol 2.00%, be warmed up to 85 DEG C by the mixing of all the other components of aqueous phase, insulation 20min, and stirring and dissolving is complete;
C, first by aqueous phase suction emulsifying pot, then suction oil phase, homogenizing 5min, insulated and stirred 5min, stir lower evacuation and be cooled to 60 DEG C, add triethanolamine adjust ph, continue cooling;
D, the menthyl lactate repaired in component after shining to be mixed with the glycerol that step b reserves, be heated to 45 DEG C and make it dissolve, adding when expecting that body is cooled to 45 DEG C in emulsifying pot, stirring;
Beta glucan, Alps glacial water, eggshell membrane polypeptide that e, material body add adjuvant component when being cooled to 40 DEG C and repair after shining in component, stir.
The present invention compared with prior art, has following advantage:
The eggshell membrane polypeptide used in the present invention can, for shining rear impaired cell Implantation Energy, give cell unlimited vigor, promotes the metabolism of skin, strengthens circulation, reach the effect of reparative regeneration; Alps glacial water, derives from natural glacial water, can open skin water circulation channel, trace element supplement, allows skin while the pure pure and fresh environment of enjoyment, carries back and obtain water replenishment by skin; Tocopherol acetas as natural antioxidant can with oxygen-derived free radicals generation redox reaction, oxygen-derived free radicals is thoroughly removed.Beta glucan can activate the such macrophage of langerhans cell, thus strengthen the function of human immune system, the langerhans cell be activated can secrete some factors, promote the synthesis of fibroblastic propagation and skin histology mechanism (as collagen protein, elastin laminin, Dan Baiduotang proteoglycan PG and other component), skin elasticity is increased, soft delicate; Menthyl lactate can effective Lavender Extract, reduces skin surface temperature, alleviates scorching erythralgia phenomenon, composite by above several functional component, reaches after shining comprehensively and effectively and repairs.
Product of the present invention can not produce anaphylaxis to user, use safety; Effect that product of the present invention is repaired afterwards in solarization there is remarkable result.
[detailed description of the invention]
Remediation composition capable after a kind of solarization, it repairs component (A phase) after containing the solarization of following percentage by weight:
Also containing oil phase component (B phase) 9.5-20%, water phase components (C phase), triethanolamine (D phase), adjuvant component (E phase) 0.5%, adjuvant component is the mixture of essence and antiseptic.
The percentage by weight of each component is that the water wherein in aqueous phase is surplus with remediation composition capable system total amount after whole solarization for radix above.
Below in conjunction with specific embodiment, the invention will be further described, and the percentage ratio in following embodiment is all weight percentage:
Embodiment 1:
Component is repaired after A phase, solarization
B phase, oil phase components
C, aqueous phase component
D, triethanolamine 0.45%
E, auxiliary agent component 0.5%.
The preparation method of embodiment 1 is:
A, being mixed by the tocopherol acetas in A phase and be warmed up to 80 DEG C with B phase, stirring and dissolving is complete;
Glycerol 2.00% in b, reserved C phase, is warmed up to 85 DEG C by the mixing of all the other components of C phase, insulation 20min, and stirring and dissolving is complete;
C, first by C phase suction emulsifying pot, then suction B phase, homogenizing 5min, insulated and stirred 5min, stir lower evacuation and be cooled to 60 DEG C, add D phase adjust ph, continue cooling;
D, the glycerol that the menthyl lactate in A phase and step b are reserved to be mixed, be heated to 45 DEG C and make it dissolve, adding when expecting that body is cooled to 45 DEG C in emulsifying pot, stirring;
E, 40 DEG C time add beta glucan, Alps glacial water, eggshell membrane polypeptide in E phase and A phase, stir.
Embodiment 2:
Component is repaired after A phase, solarization
B phase, oil phase components
C, aqueous phase component
D, triethanolamine 0.5%
E, auxiliary agent component 0.5%.
Embodiment 3:
Component is repaired after A phase, solarization
B phase, oil phase components
C, aqueous phase component
D, triethanolamine 0.20%
E, auxiliary agent component 0.5%.
Embodiment 4:
Component is repaired after A phase, solarization
B phase, oil phase components
C, aqueous phase component
D, triethanolamine 0.45%;
E, auxiliary agent component 0.5%.
Embodiment 5:
Component is repaired after A phase, solarization
B phase, oil phase components
C, aqueous phase component
D, triethanolamine 0.5%;
E, auxiliary agent component 0.5%.
Embodiment 6:
Component is repaired after A phase, solarization
B phase, oil phase components
C, aqueous phase component
D, triethanolamine 0.2%;
E, auxiliary agent component 0.5%.
The preparation method of embodiment 2-6 is identical with embodiment 1.
Do some testing performance indexes to remediation composition capable after the solarization of embodiment 1-6, its test result is as follows:
1. outward appearance: fine and smooth cream frost
2.pH value: 5.0-7.0
3. viscosity: 100000-150000mpa.s
4. heat-resistant stability investigates (48 DEG C × 24H): qualified
5. cold-resistant study on the stability (-15 DEG C × 24H): qualified.
In order to prove the performance of product of the present invention, carry out following test:
One, irritation test:
Select 2.5 ~ 3kg healthy rabbits 70, every rabbit back is symmetrical selects 20 to shave a mao 2.5cm
2, carry out with own control test method(s), each be coated with 0.5g embodiment of the present invention product or bare substrate, twice daily, the random administration in left side or right side, observes and the reacting phenomenon of skin after recording 24h, 72h.
Result shows: have no the local excitation such as skin rubefaction, dermexanthesis, water lump reaction after being coated with product 24h, 72h of the present invention, illustrating that the present invention shines rear reparation modularization cosmetic is be perfectly safe, without any untoward reaction.
Two, product Curative effect of the present invention:
The curative effect statistics of product of the present invention: trial volunteer 500 example, man 170 example, female 330 example, age reckling 17 years old, the maximum 67 years old, 34.76 years old mean age.Dry skin 410 example, neutral skin 60 example and oily skin 30 example.All experimenters are divided into 6 groups, trial edition inventive embodiments 1-6 set product respectively, embodiment 1-2 group often organizes 90 people, embodiment 4-6 often organizes 80 people, repairs modularization cosmetic after every routine experimenter uses solarization of the present invention, out of doors movable a few hours, after accepting Exposure to Sunlight to a certain degree, cleaning exposes and the skin under sunlight, and is respectively applied to skin with this invention product of about 1.00g and rubs gently, continuously one week (course for the treatment of) of use.
Effect criterion:
Excellent: conscious comfortable, erythema disappears completely, elasticity of skin increases, soft delicate;
Good: conscious general and objective sign (erythema) disappearance >=2/3;
Difference: have no obvious change before and after using.
Result: in 500 examples, effect judges the superior 480 example, accounts for 96%; Effect judges good person 20 example, and account for 4%, total effective rate is 100%.Untoward reaction is there is in whole experimenter without l example.
Claims (3)
1. a remediation composition capable after shining, repair component after it is characterized in that the solarization containing following percentage by weight:
The percentage by weight of each component is for radix with remediation composition capable system total amount after whole solarization above.
2. one according to claim 1 shines rear remediation composition capable, characterized by further comprising oil phase component 9.5-20%, adjuvant component 0.5%, and triethanolamine adjust ph is to 5.0-7.0, and water phase components surplus, wherein contains glycerol 6.0-8.0% in water phase components;
The percentage by weight of each component is for radix with remediation composition capable system total amount after whole solarization above.
3. a preparation method for combination is repaired in solarization according to claim 2 afterwards, it is characterized in that comprising the following steps:
A, the tocopherol acetas repaired after shining in component and oil phase component are mixed and are warmed up to 80 DEG C, stirring and dissolving is complete;
B, reserved glycerol 2.00%, be warmed up to 85 DEG C by the mixing of all the other components of aqueous phase, insulation 20min, and stirring and dissolving is complete;
C, first by aqueous phase suction emulsifying pot, then suction oil phase, homogenizing 5min, insulated and stirred 5min, stir lower evacuation and be cooled to 60 DEG C, add triethanolamine adjust ph, continue cooling;
D, the menthyl lactate repaired in component after shining to be mixed with the glycerol that step b reserves, be heated to 45 DEG C and make it dissolve, adding when expecting that body is cooled to 45 DEG C in emulsifying pot, stirring;
Beta glucan, Alps glacial water, eggshell membrane polypeptide that e, material body add adjuvant component when being cooled to 40 DEG C and repair after shining in component, stir.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510868359.5A CN105476886B (en) | 2015-11-30 | 2015-11-30 | A kind of after-sun composition and preparation method thereof |
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| CN201510868359.5A CN105476886B (en) | 2015-11-30 | 2015-11-30 | A kind of after-sun composition and preparation method thereof |
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| CN105476886A true CN105476886A (en) | 2016-04-13 |
| CN105476886B CN105476886B (en) | 2018-11-09 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110731917A (en) * | 2018-07-20 | 2020-01-31 | 伽蓝（集团）股份有限公司 | preparation containing glacier water, and its preparation method and application |
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| Publication number | Publication date |
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| CN105476886B (en) | 2018-11-09 |
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