CN105476870B - A kind of medicated toothpaste containing Gastrodin - Google Patents
A kind of medicated toothpaste containing Gastrodin Download PDFInfo
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- CN105476870B CN105476870B CN201610068168.5A CN201610068168A CN105476870B CN 105476870 B CN105476870 B CN 105476870B CN 201610068168 A CN201610068168 A CN 201610068168A CN 105476870 B CN105476870 B CN 105476870B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of medicated toothpaste containing Gastrodin, belongs to daily chemical products processing technique field；Gastrodin and extract are applied in toothpaste as main active by the present invention first, experimental result shows that it can effectively alleviate the symptoms such as canker sore, mucous hyperemia, cusalgia, enlargement, also can effectively remove halitosis, toothpaste of the present invention is free of antibiotic, suitable long-time service；The product active ingredient is clear and definite, safe, without side-effects, prepares simply, suitable for industrialization production, there is marketing application prospect.
Description
Technical field
The present invention relates to oral health care product, is a kind of medicated toothpaste containing Gastrodin.
Background technology
Rhizoma Gastrodiae（Gastrodia elataBl.）, also known as rhizoma gastrodiae, wind grass etc., it is that orchid family Gastrodia perennial herb is planted
Thing, is China's tradition rare traditional Chinese medicine, in China's applicating history more than 2,000 years existing.The Eastern Han Dynasty is into book《Legendary god of farming's book on Chinese herbal medicine
Through》Just run after fame record with rhizoma gastrodiae：Main to kill terrible smart thing, disease due to noxious agents produced by various parasites bad odor, long term usage benefiting energy, long cloudy fertilizer is strong, makes light of one's life by commiting suicide and increases year；Liang Tao
Great scape exists《Bencao jizhu》Middle note cloud：Its stem such as arrow shaft, redness of the skin or complexion, leaf give birth to its end, root such as people's foot, therefore named rhizoma gastrodiae；Song opens treasured six
To 7 years（973 ~ 974 years Christian eras）, Liu's writing brush and Ma Zhi et al. writing《Kaibao Bencao》, begin the name of rhizoma Gastrodiae." my god, say nature
Institute into；Fiber crops, say the shape of article.Ancients think that rhizoma Gastrodiae growth is magical, if heaven is vouchsafed, day institute facility, and its shape, class ancient times fiber crops
Footwear for it, therefore named meaning rhizoma Gastrodiae ".Bright Li Shizhen (1518-1593 A.D.) exists《Compendium of Materia Medica》Clearly stated in rolling up 12：《This warp》On have rhizoma gastrodiae, rear person
For rhizoma Gastrodiae.Rhizoma Gastrodiae medicinal part is its dry tuber, and rhizoma Gastrodiae is immune and other effects with analgesia, calmness, anti-inflammatory, enhancing.
Gastrodin, the entitled 4- hydroxymethyl phenyl-β-D- glucopyanosides of Chinese, molecular formula C13H18O7, molecular structure
Formula is the dry root block extract of orchid rhizoma Gastrodiae, Gastrodin has preferable calm and soporific function, right shown in formula I
Neurasthenia, insomnia, headache syndromes have mitigation, and gastrodia elata can treat dizziness, extremity numbness, frightened pain and twitch,
。
Formulas I
It is main using Gastrodin as the toothpaste for alleviating the oral problems such as canker sore, cusalgia, enlargement, mucous hyperemia, halitosis
Component is not reported so far.
The content of the invention
It is an object of the invention to provide a kind of medicated toothpaste containing Gastrodin, i.e., add toothpaste in conventional dentifrices matrix
The Gastrodin of weight 0.05~1.2%, alleviates the oral problems such as canker sore, cusalgia, enlargement, mucous hyperemia, halitosis to reach,
There are significantly analgesia, anti-inflammatory.
The medicated toothpaste containing Gastrodin is that Gastrodin is added in conventional dentifrices matrix, and matrix auxiliary material includes friction
Agent, moisturizer, thickener, foaming agent, sweetener, flavouring agent etc. can be used for the customary adjuvant for preparing toothpaste.
The medicated toothpaste composition of raw materials and percentage by weight containing Gastrodin are：
Gastrodin 0.05~1.2%
Rubbing agent 25~60%
Moisturizer 20~65%
Thickener 0.5~2%
Foaming agent 1~3%
Flavouring agent 0.5~2%
Sweetener 0.25~2%
Stabilizer 0.05~0.5%
Deionized water surplus.
Gastrodin is commercial product or extracts according to a conventional method in the present invention.
Wherein described rubbing agent is dicalcium phosphate dihydrate and/or hydrated silica.
The moisturizer is glycerine, one or more of mixtures in sorbierite, polyethylene glycol-400.
The thickener is cellulose gum and/or xanthans.
The foaming agent is laruyl alcohol sodium sulfovinate.
The stabilizer is sodium benzoate, and flavouring agent, sweetener are customary adjuvant.
The present invention provides the preparation method of the above-mentioned medicated toothpaste containing Gastrodin, by the percentage by weight of each component
Gastrodin, moisturizer, stabilizer and sweetener are put into stir in deionized water deionized water solution is made, with rubbing agent, increasing
Thick dose, foaming agent be mixed and vacuum outgas, then put into flavouring agent continue stirring, vacuum outgas lotion of toothpaste is made.
Another object of the present invention is to provide one kind and with the addition of Gastrodin and rhizoma Gastrodiae polyphenol extract in conventional dentifrices matrix
Medicated toothpaste, the additive amount of rhizoma Gastrodiae polyphenol extract is the 0.2~1% of toothpaste weight, and the additive amount of Gastrodin is toothpaste weight
0.05~1.2%, remaining is same as above.
The rhizoma Gastrodiae polyphenol extract is after fresh gastrodia elata is crushed, with 3~4 times of mass percent concentration of rhizoma Gastrodiae quality
5~6h is extracted for 40~60% alcohol solution dipping, filtering, filtrate is with hydrogen bond macroporous absorbent resin or polycaprolactam resin
Absorption, the ethanol solution elution of mass percent concentration 70~80%, collects eluent, neutral alumina is crossed after eluent concentration
Resin column, the ammonium hydroxide elution of mass percent concentration 20~25%, eluent are concentrated and dried to obtain rhizoma Gastrodiae polyphenol extract.
The hydrogen bond macroporous absorbent resin is HPD417 or ADS-7.
Gastrodin and/or rhizoma Gastrodiae polyphenol extract are applied to oral care by the present invention by the application study to rhizoma Gastrodiae
In product toothpaste, good using effect is achieved.
Advantages of the present invention and technique effect：
Product of the present invention can effectively alleviate the symptoms such as canker sore, mucous hyperemia, cusalgia, enlargement, also can be effectively clear
Except halitosis, the active ingredient that medicated toothpaste of the invention is added carries for the Gastrodin in rhizoma Gastrodiae, or Gastrodin and rhizoma Gastrodiae polyphenol
Thing is taken, without antibiotic, suitable long-time service；The product active ingredient is clear and definite, safe, without side-effects, prepares simply, fits
In industrialization production, there is marketing application prospect.
Embodiment
The present invention is described in further detail below by embodiment, but protection scope of the present invention be not limited to it is described
Content.
Embodiment 1：Originally the constituent of medicated toothpaste containing Gastrodin and percentage by weight are：
Gastrodin 0.05%
Dicalcium phosphate dihydrate 30%
Hydrated silica 3%
Glycerine 10%
Sorbierite 35%
Polyethylene glycol-400 3%
Cellulose gum 1%
Xanthans 0.5%
Laruyl alcohol sodium sulfovinate 2%
Saccharin sodium 0.25%
Spearmint essence 1%
Sodium benzoate 0.05%
Deionized water 14.15%；
According to the above ratio by Gastrodin 0.005kg, glycerine 1kg, sorbierite 3.5kg, polyethylene glycol-400 0.3kg, saccharin
Sodium 0.025kg, sodium benzoate 0.005kg are put into deionized water 1.415kg and are sufficiently stirred, with dicalcium phosphate dihydrate
3kg, hydrated silica 0.3kg, cellulose gum 0.1kg, xanthans 0.05kg, laruyl alcohol sodium sulfovinate 0.2kg mixing, are put into cream processed
Machine, starts high-speed stirred 30 minutes, then adds spearmint essence 0.1kg, continues stirring 20 minutes, after lotion is made in vacuum outgas
Sterilizing packing.
The toothpaste that above-described embodiment is prepared is used for canker sore patient, and observation uses rear situation, and subject totally 8
People, is canker sore patient, wherein, 5 people of women, 3 people of male, age 18-35 Sui, using toothpaste twice daily, sees after 5 days
Canker sore situation is examined, statistical result is as shown in table 1：
Table 1
。
Embodiment 2：Originally the constituent of medicated toothpaste containing Gastrodin and percentage by weight are：
Gastrodin 0.07%
Dicalcium phosphate dihydrate 40%
Hydrated silica 2%
Glycerine 8%
Sorbierite 25%
Polyethylene glycol-400 4%
Cellulose gum 1.5%
Xanthans 0.3%
Laruyl alcohol sodium sulfovinate 3%
Saccharin sodium 1%
Mint Essence 1.2%
Sodium benzoate 0.1%
Deionized water 13.83%；
According to the above ratio by Gastrodin 0.007kg, glycerine 0.8kg, sorbierite 2.5kg, polyethylene glycol-400 0.4kg, sugar
Smart sodium 0.1kg, sodium benzoate 0.01kg are put into deionized water 1.383kg and are sufficiently stirred, with dicalcium phosphate dihydrate
4kg, hydrated silica 0.2kg, cellulose gum 0.15kg, xanthans 0.03kg, laruyl alcohol sodium sulfovinate 0.3kg mixing, are put into system
Cream machine, starts high-speed stirred 30 minutes, then adds Mint Essence 0.12kg, continues stirring 20 minutes, cream is made in vacuum outgas
Sterilize packing after body.
The toothpaste that above-described embodiment is prepared is used for canker sore patient, and observation uses rear situation, and subject totally 8
People, is canker sore patient, wherein, 3 people of women, 5 people of male, age 18-35 Sui, using toothpaste twice daily, sees after 5 days
Canker sore situation is examined, statistical result is as shown in table 2：
Table 2
。
Embodiment 3：Originally the constituent of medicated toothpaste containing Gastrodin and percentage by weight are：
Gastrodin 1%
Dicalcium phosphate dihydrate 50%
Hydrated silica 1%
Glycerine 12%
Sorbierite 20%
Polyethylene glycol-400 1%
Cellulose gum 1.8%
Xanthans 0.2%
Laruyl alcohol sodium sulfovinate 1%
Saccharin sodium 2%
Spearmint essence 2%
Sodium benzoate 0.3%
7.7 % of deionized water；
According to the above ratio by Gastrodin 0.1kg, glycerine 1.2kg, sorbierite 2kg, polyethylene glycol-400 0.1kg, saccharin sodium
0.2kg, sodium benzoate 0.03kg are put into deionized water 0.77kg and are sufficiently stirred, then with dicalcium phosphate dihydrate 5kg, hydration
Silica 0.1kg, cellulose gum 0.18kg, xanthans 0.02kg, laruyl alcohol sodium sulfovinate 0.1kg mixing, are put into Manufacturing medicine extract machine, start
High-speed stirred 30 minutes, then adds spearmint essence 0.2kg, continues stirring 20 minutes, and sterilizing point after lotion is made in vacuum outgas
Dress.
The toothpaste that above-described embodiment is prepared is used for canker sore patient, and observation uses rear situation, and subject totally 8
People, is canker sore patient, wherein, 4 people of women, 4 people of male, age 18-35 Sui, using toothpaste twice daily, sees after 5 days
Canker sore situation is examined, statistical result is as shown in table 3：
Table 3
。
Embodiment 4：Originally the constituent of medicated toothpaste containing Gastrodin and percentage by weight are：
Gastrodin 1.2%
Dicalcium phosphate dihydrate 55%
Glycerine 10%
Sorbierite 20%
Xanthans 0.5%
Laruyl alcohol sodium sulfovinate 1%
Saccharin sodium 1.5%
Leaf of bamboo essence 0.5%
Sodium benzoate 0.5%
Deionized water 9.8%；
According to the above ratio by Gastrodin 0.12kg, glycerine 1kg, sorbierite 2kg, saccharin sodium 0.15kg, sodium benzoate
0.05kg is put into deionized water 0.98kg and is sufficiently stirred, then with dicalcium phosphate dihydrate 5.5kg, xanthans 0.05kg, the moon
Cinnamic alcohol sodium sulfovinate 0.1kg is mixed, and is put into Manufacturing medicine extract machine, starts high-speed stirred 30 minutes, then adds leaf of bamboo essence 0.05kg, after
Sterilizing packing after lotion is made in continuous stirring 20 minutes, vacuum outgas.
The toothpaste that above-described embodiment is prepared is used for canker sore patient, and observation uses rear situation, and subject totally 8
People, is canker sore patient, wherein, 4 people of women, 4 people of male, age 18-35 Sui, using toothpaste twice daily, sees after 5 days
Canker sore situation is examined, statistical result is as shown in table 4：
Table 4
。
Show through above-mentioned experiment, after the toothpaste of more than 90% canker sore patient continuous use addition Gastrodin, ulcer
The symptoms such as size, cusalgia, mucous hyperemia, halitosis can effectively be alleviated.Product of the present invention can make oral cavity obtain the nursing of specialty, protect
It is strong, make that oral cavity is more healthy, implication is more pure and fresh, tooth is more firm, be oral care of new generation, health product.
Embodiment 5：Originally the constituent of medicated toothpaste containing Gastrodin and percentage by weight are：
Gastrodin 0.06%
Rhizoma Gastrodiae polyphenol extract 0.2%
Dicalcium phosphate dihydrate 50%
Glycerine 12%
Sorbierite 20%
Xanthans 0.7%
Laruyl alcohol sodium sulfovinate 2%
Saccharin sodium 1%
Spearmint essence 0.5%
Sodium benzoate 0.3%
Deionized water 13.24%
Wherein described rhizoma Gastrodiae polyphenol extract is after fresh gastrodia elata is crushed, dense with 3 times of mass percent of rhizoma Gastrodiae quality
The alcohol solution dipping spent for 60% extracts 5h, filtering, and filtrate is adsorbed with hydrogen bond macroporous absorbent resin ADS-7, and mass percent is dense
The ethanol solution elution of degree 80%, collects eluent, neutral alumina resin column, mass percent concentration is crossed after eluent concentration
20% ammonium hydroxide elution, eluent are concentrated and dried to obtain rhizoma Gastrodiae polyphenol extract.
Preparation method is with embodiment 1, and the toothpaste that above-described embodiment is prepared is used for canker sore patient, and observation makes
With rear situation, subject totally 8 people, is canker sore patient, wherein, 5 people of women, 3 people of male, 18~35 years old age, daily
Using toothpaste twice, canker sore situation is observed after 5 days, statistical result is as shown in table 5：
Table 5
。
Embodiment 6：Originally the constituent of medicated toothpaste containing Gastrodin and percentage by weight are：
Gastrodin 0.5%
Rhizoma Gastrodiae polyphenol extract 0.5%
Dicalcium phosphate dihydrate 45%
Hydrated silica 3%
Glycerine 12%
Sorbierite 23%
Polyethylene glycol-400 1%
Cellulose gum 1.6%
Xanthans 0.2%
Laruyl alcohol sodium sulfovinate 1.7%
Saccharin sodium 1%
Spearmint essence 1.5%
Sodium benzoate 0.3%
Deionized water 8.7%
Wherein described rhizoma Gastrodiae polyphenol extract is after fresh gastrodia elata is crushed, dense with 4 times of mass percent of rhizoma Gastrodiae quality
The alcohol solution dipping spent for 50% extracts 6h, filtering, and filtrate is adsorbed with hydrogen bond macroporous absorbent resin HPD417, mass percent
The ethanol solution elution of concentration 75%, collects eluent, crosses neutral alumina resin column after eluent concentration, mass percent is dense
The ammonium hydroxide elution of degree 25%, eluent are concentrated and dried to obtain rhizoma Gastrodiae polyphenol extract.
Preparation method is with embodiment 1, and the toothpaste that above-described embodiment is prepared is used for canker sore patient, and observation makes
With rear situation, subject totally 8 people, is canker sore patient, wherein, 6 people of women, 2 people of male, 18~35 years old age, daily
Using toothpaste twice, canker sore situation is observed after 5 days, statistical result is as shown in table 6：
Table 6：
。
Embodiment 7：Originally the constituent of medicated toothpaste containing Gastrodin and percentage by weight are：
Gastrodin 1%
Rhizoma Gastrodiae polyphenol extract 0.8%
Dicalcium phosphate dihydrate 50%
Hydrated silica 5%
Glycerine 10%
Sorbierite 15%
Polyethylene glycol-400 3%
Cellulose gum 1%
Xanthans 0.5%
Laruyl alcohol sodium sulfovinate 2%
Saccharin sodium 0.25%
Spearmint essence 1%
Sodium benzoate 0.05%
Deionized water 10.4%
Wherein described rhizoma Gastrodiae polyphenol extract is after fresh gastrodia elata is crushed, with 3.5 times of mass percent of rhizoma Gastrodiae quality
The alcohol solution dipping that concentration is 45% extracts 6h, and filtering, filtrate is with polycaprolactam resin adsorption, mass percent concentration 70%
Ethanol solution elution, collect eluent, eluent concentration after cross neutral alumina resin column, mass percent concentration 20%
Ammonium hydroxide elutes, and eluent is concentrated and dried to obtain rhizoma Gastrodiae polyphenol extract.
Preparation method is with embodiment 1, and the toothpaste that above-described embodiment is prepared is used for canker sore patient, and observation makes
With rear situation, subject totally 8 people, is canker sore patient, wherein, 3 people of women, 5 people of male, 18~35 years old age, daily
Using toothpaste twice, canker sore situation is observed after 5 days, statistical result is as shown in table 7：
Table 7：
。
Show through above-mentioned experiment, more than 90% canker sore patient, which is used continuously, adds Gastrodin and the more phenol extractions of rhizoma Gastrodiae
After the medicated toothpaste of thing, the symptom such as the size of ulcer, cusalgia, mucous hyperemia, halitosis also can effectively be alleviated.
The related experiment of Gastrodin：
1st, calm experiment
Small white mouse 50 is taken with the SchlaginweitShi methods of improvement（18~25g of weight, half male and half female）, first it is subcutaneously injected
Caffeine sodium benzoate 50mg/kg（This medicine is typical psychoanaleptic）, increase its activity, be subcutaneously injected again after 30 minutes
0.2ml/, physiological saline and sodium phenobarbital 50mg/kg, observing time 120 is subcutaneously injected in Gastrodin 50mg/kg, control group
Minute.The mouse mean activity time of the results show injection Gastrodin reduces, and Gastrodin shows obvious sedation（It is shown in Table
8）.
Table 8：Sedation of the Gastrodin to mouse
Remarks：Calm index=physiological saline group mean activity time（min）/ medicine group mean activity the time（min）.
2nd, analgesic test
With fixed current（0.2mA）The rat-tail that shocks by electricity 0.2 second, selecting continuous 2 times stimulates the mouse for having reaction of screaming（Weight 18
~25g, male and female dual-purpose）60, be divided into three groups, every group 20,10 mg/kg of intraperitoneal injection morphine hydrochloride, Gastrodin 50mg/kg,
Only, 10min, 60min, 100min are stimulated small control group injecting normal saline 0.2ml/ with above-mentioned electric current and time again after administration
Mouse, it is all continuously not make person just think there is analgesic activity three times.The results show coffee 10 mg/kg and Gastrodin 50mg/kg have non-
Normal obvious analgesic activity.
Analgesic activity of 9 Gastrodin of table to mouse
Remarks：Analgesia rate=medicine group is not screamed mouse/medicine group total mice after continuously stimulating three times
3rd, anti-inflammatory and enhancing immune function
Magazine 1988,8 is immunized in Chen Yimin etc., influence Shanghai of the Gastrodia Injection to immune function of mice（5）:337,
With in dragon it is suitable, wait the research Chinese herbal medicines 1989,20 of rhizoma Gastrodiae anti-inflammatory effects（5）:Gastrodin note is proved in 19 grade documents
Penetrate liquid energy and significantly increase macrophage phagocytosis of mice and serum lysozyme ability；Haemolysis blank assay, IRFC are tested and resisted
SRBC test values are all remarkably higher than control group；Show Injectio of gastrodine to the cellular immunity in mouse nospecific immunity with
Humoral immunity has humidification.
Claims (8)
1. a kind of medicated toothpaste containing Gastrodin, it is characterised in that composition of raw materials and percentage by weight are：
Gastrodin 0.05~1.2%
Rubbing agent 25~60%
Moisturizer 20~65%
Thickener 0.5~2%
Foaming agent 1~3%
Flavouring agent 0.5~2%
Sweetener 0.25~2%
Stabilizer 0.05~0.5%
Deionized water surplus.
2. the medicated toothpaste according to claim 1 containing Gastrodin, it is characterised in that：Rubbing agent is hydrated for calcium monohydrogen phosphate two
Thing and/or hydrated silica.
3. the medicated toothpaste according to claim 1 containing Gastrodin, it is characterised in that：Moisturizer is glycerine, sorbierite, gathers
One or more of mixtures in ethylene glycol -400.
4. the medicated toothpaste according to claim 1 containing Gastrodin, it is characterised in that：Thickener for cellulose gum and/or
Xanthans.
5. the medicated toothpaste according to claim 1 containing Gastrodin, it is characterised in that：Foaming agent is bay alcohol sulfuric ester
Sodium.
6. the medicated toothpaste according to claim 1 containing Gastrodin, it is characterised in that：Stabilizer is sodium benzoate.
7. a kind of medicated toothpaste containing Gastrodin, it is characterised in that composition of raw materials and percentage by weight are：
Gastrodin 0.05~1.2%
Rubbing agent 25~60%
Moisturizer 20~65%
Thickener 0.5~2%
Foaming agent 1~3%
Flavouring agent 0.5~2%
Sweetener 0.25~2%
Stabilizer 0.05~0.5%
Deionized water surplus；
The rhizoma Gastrodiae polyphenol extract of toothpaste weight 0.2~1% is added at the same time；
The rhizoma Gastrodiae polyphenol extract is after fresh gastrodia elata is crushed, and is 40 with 3~4 times of mass percent concentration of rhizoma Gastrodiae quality
~60% alcohol solution dipping extracts 5~6h, filtering, filtrate with hydrogen bond macroporous absorbent resin or polycaprolactam resin adsorption,
The ethanol solution elution of mass percent concentration 70~80%, collects eluent, neutral alumina resin is crossed after eluent concentration
Column, the ammonium hydroxide elution of mass percent concentration 20~25%, eluent are concentrated and dried to obtain rhizoma Gastrodiae polyphenol extract.
8. the medicated toothpaste according to claim 7 containing Gastrodin, it is characterised in that：Hydrogen bond macroporous absorbent resin is
HPD417 or ADS-7.
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| CN113398049A (en) * | 2021-07-16 | 2021-09-17 | 深圳市西马龙科技有限公司 | Toothpaste containing antibacterial and anti-inflammatory components and preparation method thereof |
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| CN104248571A (en) * | 2014-09-19 | 2014-12-31 | 云南七丹药业股份有限公司 | Purely natural plant-containing abradant toothpaste and preparation method thereof |
| CN104434604A (en) * | 2013-09-23 | 2015-03-25 | 青岛锦涟鑫商贸有限公司 | Traditional Chinese medicine descaling tooth powder |
| CN104434605A (en) * | 2013-09-23 | 2015-03-25 | 青岛锦涟鑫商贸有限公司 | Tooth powder for treating periodontitis |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434604A (en) * | 2013-09-23 | 2015-03-25 | 青岛锦涟鑫商贸有限公司 | Traditional Chinese medicine descaling tooth powder |
| CN104434605A (en) * | 2013-09-23 | 2015-03-25 | 青岛锦涟鑫商贸有限公司 | Tooth powder for treating periodontitis |
| CN104248571A (en) * | 2014-09-19 | 2014-12-31 | 云南七丹药业股份有限公司 | Purely natural plant-containing abradant toothpaste and preparation method thereof |
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