CN105476870A - Medicated toothpaste containing gastrodin - Google Patents
Medicated toothpaste containing gastrodin Download PDFInfo
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- CN105476870A CN105476870A CN201610068168.5A CN201610068168A CN105476870A CN 105476870 A CN105476870 A CN 105476870A CN 201610068168 A CN201610068168 A CN 201610068168A CN 105476870 A CN105476870 A CN 105476870A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a medicated toothpaste containing gastrodin, and belongs to the technical field of daily chemical product processing. Gastrodin and extract are applied to the toothpaste to serve as main active ingredients for the first time, and experimental results show that the toothpaste can effectively relieve dental ulcers, mucosa hyperemia, causalgia, swelling and the like and also can effectively remove ozostomia. The toothpaste contains no antibiotic and is suitable for long-term use. The toothpaste is high in safety and free of side effects due to the definite active ingredients, is easy to prepare and suitable for industrialized production and has market application and popularization prospects.
Description
Technical field
The present invention relates to oral health care product, is a kind of medicated toothpaste containing gastrodine.
Background technology
Rhizoma Gastrodiae (GastrodiaelataBl.), has another name called rhizoma gastrodiae, DINGFENGCAO etc., is the orchid family Gastrodia herbaceos perennial, is China's tradition rare Chinese medicine, has the applicating history of more than 2,000 year in China.The Eastern Han Dynasty becomes the Shennong's Herbal of book just to run after fame records with rhizoma gastrodiae: mainly kill terrible smart thing, and diseases due to noxious agents produced by various parasites bad odor, takes physical strength profiting for a long time, long cloudy fertile strong, makes light of one's life by commiting suicide increasing year; Beam TAO Hong-Jing notes cloud in Collective Notes to the Canon of Materia medica: its stem as arrow shaft, redness of the skin or complexion, Ye Shengqi hold, root as people foot, therefore named rhizoma gastrodiae; Song opens precious 6 to seven years (973 ~ 974 years Christian eras), " Kaibao Bencao " of people's writings such as Liu's writing brush and Ma Zhi, begins the name of Rhizoma Gastrodiae." my god, speech nature become; Fiber crops, the shape of speech article.Ancients think, Rhizoma Gastrodiae growth is magical, if heaven is vouchsafed, sky institute facility, and its shape, class ancient times fiber crops footwear for it, therefore named meaning Rhizoma Gastrodiae ".Bright Li Shizhen (1518-1593 A.D.) is clearly stated in Compendium of Material Medica volume 12: " herbal classic " has rhizoma gastrodiae, and descendant is called Rhizoma Gastrodiae.Rhizoma Gastrodiae medicinal part is its dry tuber, and Rhizoma Gastrodiae has the effects such as analgesia, calmness, antiinflammatory, enhancing immunity.
Gastrodine, Chinese 4-hydroxymethyl phenyl-β-D-glucopyanoside by name, molecular formula is C
13h
18o
7, molecular structural formula, such as formula shown in I, is the dry root block extract of orchid Rhizoma Gastrodiae, and gastrodine has preferably calm and soporific function, has mitigation to neurasthenia, insomnia, headache syndromes, and gastrodia elata can be treated dizzy, numb limbs and tense tendons, frightened pain and be twitched,
。
Formula I
Be not reported so far using gastrodine as the toothpaste main component alleviating the oral problem such as oral ulcer, causalgia, enlargement, mucous hyperemia, halitosis.
Summary of the invention
The object of the present invention is to provide a kind of medicated toothpaste containing gastrodine, namely in conventional dentifrices substrate, add the gastrodine of toothpaste weight 0.05 ~ 1.2%, to reach oral problem such as alleviating oral ulcer, causalgia, enlargement, mucous hyperemia, halitosis, there is the effect of obvious analgesia, antiinflammatory.
The described medicated toothpaste containing gastrodine adds gastrodine in conventional dentifrices substrate, and substrate adjuvant comprises the customary adjuvant that abrasivus, wetting agent, thickening agent, foaming agent, sweeting agent, flavouring agent etc. can be used for preparing toothpaste.
The described medicated toothpaste composition of raw materials containing gastrodine and percentage by weight are:
Gastrodine 0.05 ~ 1.2%
Abrasivus 25 ~ 60%
Wetting agent 20 ~ 65%
Thickening agent 0.5 ~ 2%
Foaming agent 1 ~ 3%
Flavouring agent 0.5 ~ 2%
Sweeting agent 0.25 ~ 2%
Stabilizing agent 0.05 ~ 0.5%
Deionized water surplus.
In the present invention, gastrodine is commercially available prod or extracts according to a conventional method.
Wherein said abrasivus is dicalcium phosphate dihydrate and/or hydrated silica.
Described wetting agent is one or more mixture in glycerol, sorbitol, PEG-4000.
Described thickening agent is cellulose gum and/or xanthan gum.
Described foaming agent is sodium lauryl sulfate.
Described stabilizing agent is sodium benzoate, and flavouring agent, sweeting agent are customary adjuvant.
The invention provides the preparation method of the above-mentioned medicated toothpaste containing gastrodine, by the percentage by weight of described each component, gastrodine, wetting agent, stabilizing agent and sweeting agent are put into deionized water for stirring and obtain deionized water solution, with abrasivus, thickening agent, foaming agent mix and blend vacuum outgas, then drop into that flavouring agent continues to stir, vacuum outgas obtains lotion of toothpaste.
Another object of the present invention is to provide a kind of medicated toothpaste that with the addition of gastrodine and Rhizoma Gastrodiae polyphenol extract in conventional dentifrices substrate, the addition of Rhizoma Gastrodiae polyphenol extract is 0.2 ~ 1% of toothpaste weight, the addition of gastrodine is 0.05 ~ 1.2% of toothpaste weight, and all the other are the same.
Described Rhizoma Gastrodiae polyphenol extract is after being pulverized by fresh gastrodia elata, 5 ~ 6h is extracted with the alcohol solution dipping that the mass percent concentration of Rhizoma Gastrodiae quality 3 ~ 4 times is 40 ~ 60%, filter, filtrate is with hydrogen bond macroporous adsorbent resin or polycaprolactam resin absorption, the alcoholic solution eluting of mass percent concentration 70 ~ 80%, collects eluent, crosses neutral alumina resin column after eluent is concentrated, the ammonia eluting of mass percent concentration 20 ~ 25%, eluent concentrate drying obtains Rhizoma Gastrodiae polyphenol extract.
Described hydrogen bond macroporous adsorbent resin is HPD417 or ADS-7.
The present invention, by the applied research to Rhizoma Gastrodiae, is applied to gastrodine and/or Rhizoma Gastrodiae polyphenol extract in oral care product toothpaste, achieves good result of use.
Advantage of the present invention and technique effect:
Product of the present invention all can effectively be alleviated symptoms such as oral ulcer, mucous hyperemia, causalgia, enlargements, also effectively can remove halitosis, the active component that medicated toothpaste of the present invention adds is the gastrodine in Rhizoma Gastrodiae, or gastrodine and Rhizoma Gastrodiae polyphenol extract, not containing antibiotic, suitable life-time service; This product effective ingredient is clear and definite, safety is high, have no side effect, and preparation is simple, is suitable for industrialization and produces, have marketing application prospect.
Detailed description of the invention
Below by embodiment, the present invention is described in further detail, but protection scope of the present invention is not limited to described content.
Embodiment 1: this constituent containing the medicated toothpaste of gastrodine and percentage by weight are:
Gastrodine 0.05%
Dicalcium phosphate dihydrate 30%
Hydrated silica 3%
Glycerol 10%
Sorbitol 35%
PEG-4000 3%
Cellulose gum 1%
Xanthan gum 0.5%
Sodium lauryl sulfate 2%
Saccharin sodium 0.25%
Herba Menthae Rotundifoliae essence 1%
Sodium benzoate 0.05%
Deionized water 14.15%;
According to the above ratio gastrodine 0.005kg, glycerol 1kg, sorbitol 3.5kg, PEG-4000 .3kg, saccharin sodium 0.025kg, sodium benzoate 0.005kg are put into deionized water 1.415kg and fully stir, mixing with dicalcium phosphate dihydrate 3kg, hydrated silica 0.3kg, cellulose gum 0.1kg, xanthan gum 0.05kg, sodium lauryl sulfate 0.2kg, put into Manufacturing medicine extract machine, start high-speed stirred 30 minutes, then add Herba Menthae Rotundifoliae essence 0.1kg, continue stirring 20 minutes, vacuum outgas obtains sterilizing subpackage after mastic.
The toothpaste that above-described embodiment prepares uses for oral ulcer patient, observe situation after using, experimenter is totally 8 people, is all oral ulcer patients, wherein, women 5 people, male 3 people, in age 18-35 year, uses twice, toothpaste every day, within 5 days, observe oral ulcer situation afterwards, statistical result is as shown in table 1:
Table 1
。
Embodiment 2: this constituent containing the medicated toothpaste of gastrodine and percentage by weight are:
Gastrodine 0.07%
Dicalcium phosphate dihydrate 40%
Hydrated silica 2%
Glycerol 8%
Sorbitol 25%
PEG-4000 4%
Cellulose gum 1.5%
Xanthan gum 0.3%
Sodium lauryl sulfate 3%
Saccharin sodium 1%
Mint Essence 1.2%
Sodium benzoate 0.1%
Deionized water 13.83%;
According to the above ratio gastrodine 0.007kg, glycerol 0.8kg, sorbitol 2.5kg, PEG-4000 .4kg, saccharin sodium 0.1kg, sodium benzoate 0.01kg are put into deionized water 1.383kg and fully stir, mixing with dicalcium phosphate dihydrate 4kg, hydrated silica 0.2kg, cellulose gum 0.15kg, xanthan gum 0.03kg, sodium lauryl sulfate 0.3kg, put into Manufacturing medicine extract machine, start high-speed stirred 30 minutes, then add Mint Essence 0.12kg, continue stirring 20 minutes, vacuum outgas obtains sterilizing subpackage after mastic.
The toothpaste that above-described embodiment prepares uses for oral ulcer patient, observe situation after using, experimenter is totally 8 people, is all oral ulcer patients, wherein, women 3 people, male 5 people, in age 18-35 year, uses twice, toothpaste every day, within 5 days, observe oral ulcer situation afterwards, statistical result is as shown in table 2:
Table 2
。
Embodiment 3: this constituent containing the medicated toothpaste of gastrodine and percentage by weight are:
Gastrodine 1%
Dicalcium phosphate dihydrate 50%
Hydrated silica 1%
Glycerol 12%
Sorbitol 20%
PEG-4000 1%
Cellulose gum 1.8%
Xanthan gum 0.2%
Sodium lauryl sulfate 1%
Saccharin sodium 2%
Herba Menthae Rotundifoliae essence 2%
Sodium benzoate 0.3%
Deionized water 7.7%;
According to the above ratio gastrodine 0.1kg, glycerol 1.2kg, sorbitol 2kg, PEG-4000 .1kg, saccharin sodium 0.2kg, sodium benzoate 0.03kg are put into deionized water 0.77kg and fully stir, mix with dicalcium phosphate dihydrate 5kg, hydrated silica 0.1kg, cellulose gum 0.18kg, xanthan gum 0.02kg, sodium lauryl sulfate 0.1kg again, put into Manufacturing medicine extract machine, start high-speed stirred 30 minutes, then add Herba Menthae Rotundifoliae essence 0.2kg, continue stirring 20 minutes, vacuum outgas obtains sterilizing subpackage after mastic.
The toothpaste that above-described embodiment prepares uses for oral ulcer patient, observe situation after using, experimenter is totally 8 people, is all oral ulcer patients, wherein, women 4 people, male 4 people, in age 18-35 year, uses twice, toothpaste every day, within 5 days, observe oral ulcer situation afterwards, statistical result is as shown in table 3:
Table 3
。
Embodiment 4: this constituent containing the medicated toothpaste of gastrodine and percentage by weight are:
Gastrodine 1.2%
Dicalcium phosphate dihydrate 55%
Glycerol 10%
Sorbitol 20%
Xanthan gum 0.5%
Sodium lauryl sulfate 1%
Saccharin sodium 1.5%
Folium Bambusae essence 0.5%
Sodium benzoate 0.5%
Deionized water 9.8%;
According to the above ratio gastrodine 0.12kg, glycerol 1kg, sorbitol 2kg, saccharin sodium 0.15kg, sodium benzoate 0.05kg are put into deionized water 0.98kg and fully stir, mix with dicalcium phosphate dihydrate 5.5kg, xanthan gum 0.05kg, sodium lauryl sulfate 0.1kg again, put into Manufacturing medicine extract machine, start high-speed stirred 30 minutes, then add Folium Bambusae essence 0.05kg, continue stirring 20 minutes, vacuum outgas obtains sterilizing subpackage after mastic.
The toothpaste that above-described embodiment prepares uses for oral ulcer patient, observe situation after using, experimenter is totally 8 people, is all oral ulcer patients, wherein, women 4 people, male 4 people, in age 18-35 year, uses twice, toothpaste every day, within 5 days, observe oral ulcer situation afterwards, statistical result is as shown in table 4:
Table 4
。
Show through above-mentioned experiment, after the oral ulcer patient of more than 90% uses the toothpaste adding gastrodine continuously, the symptom such as size, causalgia, mucous hyperemia, halitosis of ulcer all can effectively be alleviated.Product of the present invention can make oral cavity obtain nursing, the health care of specialty, and making that oral cavity is more healthy, implication is more pure and fresh, tooth is more firm, is mouth care of new generation, health promoting product.
Embodiment 5: this constituent containing the medicated toothpaste of gastrodine and percentage by weight are:
Gastrodine 0.06%
Rhizoma Gastrodiae polyphenol extract 0.2%
Dicalcium phosphate dihydrate 50%
Glycerol 12%
Sorbitol 20%
Xanthan gum 0.7%
Sodium lauryl sulfate 2%
Saccharin sodium 1%
Herba Menthae Rotundifoliae essence 0.5%
Sodium benzoate 0.3%
Deionized water 13.24%
Wherein said Rhizoma Gastrodiae polyphenol extract is after being pulverized by fresh gastrodia elata, 5h is extracted with the alcohol solution dipping that the mass percent concentration of Rhizoma Gastrodiae quality 3 times is 60%, filter, filtrate is adsorbed with hydrogen bond macroporous adsorbent resin ADS-7, the alcoholic solution eluting of mass percent concentration 80%, collects eluent, crosses neutral alumina resin column after eluent is concentrated, the ammonia eluting of mass percent concentration 20%, eluent concentrate drying obtains Rhizoma Gastrodiae polyphenol extract.
Preparation method is with embodiment 1, the toothpaste that above-described embodiment prepares uses for oral ulcer patient, and observe situation after using, experimenter is totally 8 people, all oral ulcer patients, wherein, women 5 people, male 3 people, 18 ~ 35 years old age, use twice, toothpaste every day, within 5 days, observe oral ulcer situation afterwards, statistical result is as shown in table 5:
Table 5
。
Embodiment 6: this constituent containing the medicated toothpaste of gastrodine and percentage by weight are:
Gastrodine 0.5%
Rhizoma Gastrodiae polyphenol extract 0.5%
Dicalcium phosphate dihydrate 45%
Hydrated silica 3%
Glycerol 12%
Sorbitol 23%
PEG-4000 1%
Cellulose gum 1.6%
Xanthan gum 0.2%
Sodium lauryl sulfate 1.7%
Saccharin sodium 1%
Herba Menthae Rotundifoliae essence 1.5%
Sodium benzoate 0.3%
Deionized water 8.7%
Wherein said Rhizoma Gastrodiae polyphenol extract is after being pulverized by fresh gastrodia elata, 6h is extracted with the alcohol solution dipping that the mass percent concentration of Rhizoma Gastrodiae quality 4 times is 50%, filter, filtrate is adsorbed with hydrogen bond macroporous adsorbent resin HPD417, the alcoholic solution eluting of mass percent concentration 75%, collects eluent, crosses neutral alumina resin column after eluent is concentrated, the ammonia eluting of mass percent concentration 25%, eluent concentrate drying obtains Rhizoma Gastrodiae polyphenol extract.
Preparation method is with embodiment 1, the toothpaste that above-described embodiment prepares uses for oral ulcer patient, and observe situation after using, experimenter is totally 8 people, all oral ulcer patients, wherein, women 6 people, male 2 people, 18 ~ 35 years old age, use twice, toothpaste every day, within 5 days, observe oral ulcer situation afterwards, statistical result is as shown in table 6:
Table 6:
。
Embodiment 7: this constituent containing the medicated toothpaste of gastrodine and percentage by weight are:
Gastrodine 1%
Rhizoma Gastrodiae polyphenol extract 0.8%
Dicalcium phosphate dihydrate 50%
Hydrated silica 5%
Glycerol 10%
Sorbitol 15%
PEG-4000 3%
Cellulose gum 1%
Xanthan gum 0.5%
Sodium lauryl sulfate 2%
Saccharin sodium 0.25%
Herba Menthae Rotundifoliae essence 1%
Sodium benzoate 0.05%
Deionized water 10.4%
Wherein said Rhizoma Gastrodiae polyphenol extract is after being pulverized by fresh gastrodia elata, 6h is extracted with the alcohol solution dipping that the mass percent concentration of Rhizoma Gastrodiae quality 3.5 times is 45%, filter, filtrate uses polycaprolactam resin absorption, the alcoholic solution eluting of mass percent concentration 70%, collects eluent, crosses neutral alumina resin column after eluent is concentrated, the ammonia eluting of mass percent concentration 20%, eluent concentrate drying obtains Rhizoma Gastrodiae polyphenol extract.
Preparation method is with embodiment 1, the toothpaste that above-described embodiment prepares uses for oral ulcer patient, and observe situation after using, experimenter is totally 8 people, all oral ulcer patients, wherein, women 3 people, male 5 people, 18 ~ 35 years old age, use twice, toothpaste every day, within 5 days, observe oral ulcer situation afterwards, statistical result is as shown in table 7:
Table 7:
。
Show through above-mentioned experiment, after the oral ulcer patient of more than 90% uses the medicated toothpaste adding gastrodine and Rhizoma Gastrodiae polyphenol extract continuously, the symptom such as size, causalgia, mucous hyperemia, halitosis of ulcer also can effectively be alleviated.
The related experiment of gastrodine:
1, calm test
White mice 50 (body weight 18 ~ 25g are got by the SchlaginweitShi method of improvement, male and female half and half), first this medicine of subcutaneous injection caffeine sodium benzoate 50mg/kg(is typical psychostimulant), its activity is increased, subcutaneous injection gastrodine 50mg/kg again after 30 minutes, matched group subcutaneous injection normal saline 0.2ml/ and sodium phenobarbital 50mg/kg, observing time is 120 minutes.The mice mean activity time of result display injection gastrodine reduces, and gastrodine demonstrates obvious sedation (see table 8).
Table 8: gastrodine is to the sedation of mice
Remarks: calm index=normal saline group mean activity time (min)/medicine group mean activity time (min).
2, analgesic test
To shock by electricity Mus tail 0.2 second with fixed current (0.2mA), select continuous 2 times and stimulate the mice (body weight 18 ~ 25g having and scream and react, male and female dual-purpose) 60, be divided into three groups, often organize 20, only, after administration, 10min, 60min, 100min stimulate mice with above-mentioned electric current and time again for lumbar injection morphine hydrochloride 10mg/kg, gastrodine 50mg/kg, matched group injecting normal saline 0.2ml/, allly do not make for three times person just think there is analgesic activity continuously.Result display coffee 10mg/kg and gastrodine 50mg/kg has obviously analgesic activity.
Table 9 gastrodine is to the analgesic activity of mice
Remarks: mice/medicine group total mice of not screaming after continuous three stimulations of analgesia rate=medicine group
3, antiinflammatory and enhancing immunologic function
Chen Yimin etc., Gastrodia Injection is on the impact of immune function of mice. Shanghai immunity magazine .1988,8(5): 337, with suitable in dragon, Deng. the research of Rhizoma Gastrodiae anti-inflammatory effect. Chinese herbal medicine .1989,20(5): prove in 19 documents such as grade that gastrodine injection significantly can strengthen macrophage phagocytosis of mice and serum lysozyme ability; Haemolysis blank experiment, IRFC test and anti-SRBC test value are all significantly higher than matched group; Show that gastrodine injection all has potentiation to the cellular immunization in mice nonspecific immunity and humoral immunization.
Claims (9)
1., containing a medicated toothpaste for gastrodine, it is characterized in that the gastrodine adding toothpaste weight 0.05 ~ 1.2% in toothpaste conventional substrate.
2. the medicated toothpaste containing gastrodine according to claim 1, is characterized in that composition of raw materials and percentage by weight are:
Gastrodine 0.05 ~ 1.2%
Abrasivus 25 ~ 60%
Wetting agent 20 ~ 65%
Thickening agent 0.5 ~ 2%
Foaming agent 1 ~ 3%
Flavouring agent 0.5 ~ 2%
Sweeting agent 0.25 ~ 2%
Stabilizing agent 0.05 ~ 0.5%
Deionized water surplus.
3. the medicated toothpaste containing gastrodine according to claim 2, is characterized in that: abrasivus is dicalcium phosphate dihydrate and/or hydrated silica.
4. the medicated toothpaste containing gastrodine according to claim 2, is characterized in that: wetting agent is one or more mixture in glycerol, sorbitol, PEG-4000.
5. the medicated toothpaste containing gastrodine according to claim 2, is characterized in that: thickening agent is cellulose gum and/or xanthan gum.
6. the medicated toothpaste containing gastrodine according to claim 2, is characterized in that: foaming agent is sodium lauryl sulfate.
7. the medicated toothpaste containing gastrodine according to claim 2, is characterized in that: stabilizing agent is sodium benzoate.
8. the medicated toothpaste containing gastrodine according to claim 1, is characterized in that: the Rhizoma Gastrodiae polyphenol extract adding toothpaste weight 0.2 ~ 1% while adding gastrodine;
Described Rhizoma Gastrodiae polyphenol extract is after being pulverized by fresh gastrodia elata, 5 ~ 6h is extracted with the alcohol solution dipping that the mass percent concentration of Rhizoma Gastrodiae quality 3 ~ 4 times is 40 ~ 60%, filter, filtrate is with hydrogen bond macroporous adsorbent resin or polycaprolactam resin absorption, the alcoholic solution eluting of mass percent concentration 70 ~ 80%, collects eluent, crosses neutral alumina resin column after eluent is concentrated, the ammonia eluting of mass percent concentration 20 ~ 25%, eluent concentrate drying obtains Rhizoma Gastrodiae polyphenol extract.
9. the medicated toothpaste containing gastrodine according to claim 8, is characterized in that: hydrogen bond macroporous adsorbent resin is HPD417 or ADS-7.
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| CN113398049A (en) * | 2021-07-16 | 2021-09-17 | 深圳市西马龙科技有限公司 | Toothpaste containing antibacterial and anti-inflammatory components and preparation method thereof |
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| CN112274465A (en) * | 2020-10-26 | 2021-01-29 | 曹静娟 | Formula and preparation method of gastrodia elata toothpaste |
| CN113398049A (en) * | 2021-07-16 | 2021-09-17 | 深圳市西马龙科技有限公司 | Toothpaste containing antibacterial and anti-inflammatory components and preparation method thereof |
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