CN105770078A - Pharmaceutical composition as well as preparation and application thereof - Google Patents
Pharmaceutical composition as well as preparation and application thereof Download PDFInfo
- Publication number
- CN105770078A CN105770078A CN201610144586.8A CN201610144586A CN105770078A CN 105770078 A CN105770078 A CN 105770078A CN 201610144586 A CN201610144586 A CN 201610144586A CN 105770078 A CN105770078 A CN 105770078A
- Authority
- CN
- China
- Prior art keywords
- fructus
- pharmaceutical composition
- weight portion
- corii asini
- colla corii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000000825 pharmaceutical preparation Substances 0.000 title claims abstract description 5
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 40
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 40
- 235000008434 ginseng Nutrition 0.000 claims abstract description 40
- 210000004369 blood Anatomy 0.000 claims abstract description 25
- 239000008280 blood Substances 0.000 claims abstract description 25
- 239000003814 drug Substances 0.000 claims abstract description 25
- 239000002994 raw material Substances 0.000 claims abstract description 25
- 230000036039 immunity Effects 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 7
- 108010052008 colla corii asini Proteins 0.000 claims description 71
- 241000208340 Araliaceae Species 0.000 claims description 39
- 241000628997 Flos Species 0.000 claims description 36
- 235000003935 Hippophae Nutrition 0.000 claims description 36
- 241000229143 Hippophae Species 0.000 claims description 36
- 239000007788 liquid Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 235000013305 food Nutrition 0.000 claims description 8
- 108010011485 Aspartame Proteins 0.000 claims description 7
- 240000000851 Vaccinium corymbosum Species 0.000 claims description 7
- 235000003095 Vaccinium corymbosum Nutrition 0.000 claims description 7
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims description 7
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 7
- 239000000605 aspartame Substances 0.000 claims description 7
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 7
- 235000010357 aspartame Nutrition 0.000 claims description 7
- 229960003438 aspartame Drugs 0.000 claims description 7
- 235000021014 blueberries Nutrition 0.000 claims description 7
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 7
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 7
- 239000008213 purified water Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 239000000811 xylitol Substances 0.000 claims description 7
- 235000010447 xylitol Nutrition 0.000 claims description 7
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 7
- 229960002675 xylitol Drugs 0.000 claims description 7
- 230000002929 anti-fatigue Effects 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims description 2
- 238000007689 inspection Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 12
- 235000013399 edible fruits Nutrition 0.000 abstract description 3
- 230000003285 pharmacodynamic effect Effects 0.000 abstract description 3
- 235000013402 health food Nutrition 0.000 abstract description 2
- 241001550206 Colla Species 0.000 abstract 1
- 240000000950 Hippophae rhamnoides Species 0.000 abstract 1
- 235000003145 Hippophae rhamnoides Nutrition 0.000 abstract 1
- 241000218231 Moraceae Species 0.000 abstract 1
- 235000008708 Morus alba Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 241000220317 Rosa Species 0.000 abstract 1
- 241000109329 Rosa xanthina Species 0.000 abstract 1
- 235000004789 Rosa xanthina Nutrition 0.000 abstract 1
- 240000007651 Rubus glaucus Species 0.000 abstract 1
- 235000021013 raspberries Nutrition 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 38
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 17
- 241000699670 Mus sp. Species 0.000 description 10
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 9
- 210000004072 lung Anatomy 0.000 description 9
- 239000012141 concentrate Substances 0.000 description 8
- 238000001035 drying Methods 0.000 description 8
- 238000000605 extraction Methods 0.000 description 8
- 150000005838 radical anions Chemical group 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 230000002708 enhancing effect Effects 0.000 description 7
- 230000003064 anti-oxidating effect Effects 0.000 description 6
- 239000002671 adjuvant Substances 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 239000000706 filtrate Substances 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 5
- 230000032683 aging Effects 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 230000000259 anti-tumor effect Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 239000011573 trace mineral Substances 0.000 description 4
- 235000013619 trace mineral Nutrition 0.000 description 4
- 102000001554 Hemoglobins Human genes 0.000 description 3
- 108010054147 Hemoglobins Proteins 0.000 description 3
- 238000012449 Kunming mouse Methods 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000002481 ethanol extraction Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000010534 mechanism of action Effects 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 230000001502 supplementing effect Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 241000283074 Equus asinus Species 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 241000590428 Panacea Species 0.000 description 2
- 239000012980 RPMI-1640 medium Substances 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000002607 hemopoietic effect Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 208000033065 inborn errors of immunity Diseases 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 230000009182 swimming Effects 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 208000027219 Deficiency disease Diseases 0.000 description 1
- 229920000045 Dermatan sulfate Polymers 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 206010015719 Exsanguination Diseases 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033546 Pallor Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 208000001435 Thromboembolism Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- BKTZCDBMEXUHDR-UHFFFAOYSA-N acetic acid azane Chemical compound N.N.N.CC(O)=O BKTZCDBMEXUHDR-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000011748 cell maturation Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 1
- 229940051593 dermatan sulfate Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009661 fatigue test Methods 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000007233 immunological mechanism Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000021332 multicellular organism growth Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000000422 nocturnal effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000003405 preventing effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 208000010540 rapid respiration Diseases 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 210000000955 splenic vein Anatomy 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of traditional Chinese medicine or health food, and particularly relates to pharmaceutical composition as well as a preparation and application thereof. The pharmaceutical preparation is prepared from the pharmaceutical composition and is prepared from the following raw materials: colla corri asini, ginseng, roses, seabuckthorn fruits, singli roxbrugh rose fruits, mulberries and raspberries. Pharmacodynamic studies show that the composition has quite good effects of immunity enhancement, blood enriching, fatigue resistance and the like.
Description
Technical field
The invention belongs to technical field of Chinese medicines or technical field of health care food, be specifically related to a kind of pharmaceutical composition containing the Chinese medicine such as Colla Corii Asini, Radix Ginseng and preparation thereof and purposes.
Background technology
Colla Corii Asini (CollaCoriiAsini) is dry skin or the Cortex Dictamni blob of viscose through decocting, concentration is made of equine species donkey (EquusasinusL.), it is the traditional famous and precious Chinese medicine of China, with Radix Ginseng, Cornu Cervi Pantotrichum claim " Chinese medicine three essentials-essence ", and have the title of " panacea of enriching blood ".Shennong's Herbal records the raw Dongping Prefecture of Colla Corii Asini, and it boils donkey skin and makes.Colla Corii Asini sweet in the mouth, property are flat, return lung, liver, kidney channel.Colla Corii Asini has YIN nourishing of enriching blood, moisturizes, effect of hemostasis.Li Shizhen (1518-1593 A.D.) also has very detailed record in Compendium of Material Medica: " treating and spit blood, epistaxis, stranguria with blood, hematuria; hemorrhoidal hamorrhage dysentery, woman's blood pain blood depletion, irregular menstruation, loss of fecundity; metrorrhagia leukorrhagia, all diseases in puerperal before tire, all syndrome caused by wind pathogen of men and women, arthralgia; aqueous vapor edema, cough due to consumptive disease, dyspnea with rapid respiration, lung withers spitting bloody pus; swollen ulcer drug, and blood YIN nourishing, except wind is moisturized; reduce phlegm lung heat clearing diuresis, tunes up intestinal, and panacea is also.”
Theory about Colla Corii Asini pharmacological mechanism mainly has at present: aminoacid and trace element theory, poly-radical anion structure theory.Aminoacid and trace element theory think that the blood tonification effect of Colla Corii Asini is because it contains caused by essential amino acid and trace element, and this achievement in research obtains the accreditation of most scholar.Glycine in Colla Corii Asini, by regulating serum levels of iron, promotes the synthesis of hemoglobin；Arginine can make body growth hormone and testosterone secretion increasing, promotes the synthesis of hemoglobin；Threonine, histidine, lysine are respectively provided with hematosis.Colla Corii Asini contains abundant ferrum element and substantial amounts of animal proteinum, is a kind of supplements-iron very easily absorbed, and long-term taking can make the intake of ferrum element in body increase, and recovers ferrum element physiological function in vivo, efficiently controls iron deficiency anemia.Copper is the important component of tens of kinds of enzymes and erythrocytic component, simultaneously facilitates utilization and the hematopoiesis of ferrum, and participates in the synthesis of immunologic mechanism and elastin laminin.Take Colla Corii Asini and can supplement the copper that body is required, and absorption and the utilization of ferrum can be accelerated, make the ferrum of absorption and manganese etc. trace element is collaborative to produce hemopoietic effect.Poly-radical anion structure theory thinks that in Colla Corii Asini preparation process, hydrophobic collagen albumen completes the transformation of " hydrophilic colloid " this structure under the effect of the factors such as temperature, moisture, time, forms unique poly-radical anion structure.Radical anion can regulate the affinity of oxygen and hemoglobin；Radical anion in the factors such as epithelical cell growth factor (EGF) is probably the key of angiogenic effect；In immunity, infecting and in inflammatory process, the formation of radical anion can cause the resistance to antibacterial traverse cell, forms a barrier；In hemostasis, anticoagulation process, the anion number with the activity of the glycosaminoglycans (GAG) of radical anion and the polysaccharide of its polymer length and combination is directly proportional, adjustable blood coagulation status according to this.The two theory explains Colla Corii Asini nourishing blood more satisfactorily, replenishes the calcium, the mechanism of action of enhancing immunity etc..About Colla Corii Asini anastalsis mechanism, the author think reduce blood vessel wall with it permeability, increase platelet counts relevant；Also attach to blood vessel wall with collagen protein and promote that platelet aggregation is relevant；And dermatan sulfate and Dan Baiduotang proteoglycan PG thereof contained by discovered in recent years Colla Corii Asini, there is poly-radical anion structure and various biological activity, stop blooding with it and many-sided effect such as thromboembolism preventing, antiinflammatory, antitumor, infection and injury repairing is closely related, be worth further investigation further.At present, the curative effect of Colla Corii Asini specifically which composition in action, acts on which position of human body, by which kind of mode is absorbed, is distributed and excretion etc., and also in conceptual phase, the research of Colla Corii Asini mechanism of action also will experience a very long course.Believe and crack clinical treatment, the health cares such as the tonifying blood and arresting bleeding of Colla Corii Asini, antiabortive, defying age, shock, antitumor, enhancing immunity, promotion calcium absorption and storage at last by modern high tech methods such as genetic engineering, molecular biology, cytobiologies, it is determined that its relevant effective ingredient and mechanism of action.
In sum, it is necessary to the Chinese medicine containing Colla Corii Asini or health food are researched and developed, thus being pushed further into the development of the Colla Corii Asini modernization of Chinese medicine.
Summary of the invention
For these reasons, applicant is through clinical research for many years, based on theory of Chinese medical science, in conjunction with modern medicine study, invents a kind of new pharmaceutical composition, and said composition raw material is: Colla Corii Asini, Radix Ginseng, Flos Rosae Rugosae, Fructus Hippophae, Fructus Rosae Normalis, Fructus Mori, Fructus Rubi.Pharmacodynamic study shows, the present composition have well improve immunity, enrich blood, the effect such as antioxidation.
Colla Corii Asini in the present composition, sweet, flat.Return lung, liver, kidney channel.Enrich blood YIN nourishing, moisturize.Rich in ossein, aminoacid.Be conducive to hemopoietic, blood vessel dilatation, looks improving and the skin nourishing, enhancing immunity.Radix Ginseng, hardship sweet, micro-, tepor.Return spleen, lung, the heart, kidney channel.Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid and nourishes blood, Fructus Alpiniae Oxyphyllae of calming the nerves.Rich in Saponin, aminoacid, polysaccharide.Remarkable efficacy is had in enhancing immunity, antioxidation.Flos Rosae Rugosae, hardship sweet, micro-, it is slightly cold.Attach to the lung and stomach meridians.Promoting QI circulation for relieving depression, and blood, pain relieving.Rich in volatile oil, eugenol, total flavones, VC.Fructus Hippophae, hardship sweet, micro-, it is slightly cold.Attach to the lung and stomach meridians.Strengthening the spleen to promote digestion, eliminating phlegm and stopping cough, promoting blood circulation to remove blood stasis.Rich in flavonoid, triterpene steroidal, vitamin A, B, C, E, folic acid.Remarkable efficacy is had in strengthening immunity, antitumor, improving cardiac function, defying age.Fructus Rosae Normalis is a kind of natural medicine food dual purpose plant, rich in VC, is a kind of building body, the medicine-food two-purpose type fruit prevented and cured diseases, has the functions such as adjustment body's immunity, slow down aging, atherosclerosis and antitumor.Fructus Mori, sweet, sour, cold.GUIXIN, liver, kidney channel.Nourishing YIN and supplementing blood, promotes the production of body fluid and moisturizes.Rich in rutin, VB1, VB2, VC, anthocyanin.Good effect is had in strengthening immunity, short cell maturation, promoting hematopoietic function, blood pressure lowering, looks improving and the skin nourishing, antioxidation.Fructus Rubi, hardship sweet, micro-, it is slightly cold.Attach to the lung and stomach meridians.Supplementing the kidney to control the nocturnal reducing urination, nourishing the liver to improve visual acuity.Rich in polysaccharide, VC, organic acid.Antibacterial, anti-aging effects is notable.
Colla Corii Asini and Radix Ginseng in formula, Papillary is monarch drug altogether, nourishing YIN and supplementing blood, moisturize promote the production of body fluid, supplement vigour, thus reaching enhancing immunity, antioxidation, slow down aging, the purpose of looks improving and the skin nourishing.Flos Rosae Rugosae, Fructus Hippophae itself have good antioxidation, the effect of slow down aging, assist Colla Corii Asini and Radix Ginseng altogether for ministerial drug, to strengthen effect after share.Help with Fructus Rosae Normalis, Fructus Mori, Fructus Rubi, jointly reach enhancing immunity, antioxidative function.All tastes share, and play enhancing immunity, antioxidation, slow down aging altogether, effect of looks improving and the skin nourishing.
The present invention is achieved through the following technical solutions.
A kind of pharmaceutical composition, pharmaceutical composition prepares into pharmaceutical preparation, and its pharmaceutical formulations is prepared from by following raw material: Colla Corii Asini, Radix Ginseng, Flos Rosae Rugosae, Fructus Hippophae, Fructus Rosae Normalis, Fructus Mori, Fructus Rubi.
Preferred pharmaceutical composition, wherein Colla Corii Asini 4-6 weight portion, Radix Ginseng 4-6 weight portion, Flos Rosae Rugosae 4-6 weight portion, Fructus Hippophae 8-12 weight portion, Fructus Rosae Normalis 8-12 weight portion, Fructus Mori 8-12 weight portion, Fructus Rubi 8-12 weight portion.
Preferred pharmaceutical composition, wherein Colla Corii Asini 5 weight portion, Radix Ginseng 5 weight portion, Flos Rosae Rugosae 5 weight portion, Fructus Hippophae 10 weight portion, Fructus Rosae Normalis 10 weight portion, Fructus Mori 10 weight portion, Fructus Rubi 10 weight portion.
A kind of pharmaceutical composition described above, it is characterised in that pharmaceutical composition improves the application in immunity medicine or food in preparation.
A kind of pharmaceutical composition described above, it is characterised in that pharmaceutical composition application in preparation medicament for enriching blood or food.
A kind of pharmaceutical composition described above, it is characterised in that pharmaceutical composition application in preparing anti-fatigue medicament or food.
A kind of pharmaceutical composition described above, its pharmaceutical formulations includes oral formulations.
A kind of pharmaceutical composition described above, its pharmaceutical formulations includes medicated wine.
The preparation method of medicated wine described above is:
Take Radix Ginseng, Flos Rosae Rugosae, Fructus Hippophae, Fructus Rosae Normalis, Fructus Mori, Fructus Rubi first to soak 6-18 hour with claret, filter, standby；Colla Corii Asini is used purified water molten, obtains Colla Corii Asini liquid, standby；Finally Colla Corii Asini liquid, blue berry concentrated juice and xylitol, aspartame are joined in above-mentioned wine, stir, filter, fill, outer package, inspection, warehouse-in.
Detailed description of the invention
Pharmacodynamic experiment
Test example 1 improves immunity test
Experimental animal: BALB/C male mice, body weight 18-20g.
Trial drug:
Test 1 group: Colla Corii Asini 4g, Radix Ginseng 4g, Flos Rosae Rugosae 4g, Fructus Hippophae 8g, Fructus Rosae Normalis 8g, Fructus Mori 8g, Fructus Rubi 8g.
Test 2 groups: Colla Corii Asini 6g, Radix Ginseng 6g, Flos Rosae Rugosae 6g, Fructus Hippophae 12g, Fructus Rosae Normalis 12g, Fructus Mori 12g, Fructus Rubi 12g.
Test 3 groups: Colla Corii Asini 5g, Radix Ginseng 5g, Flos Rosae Rugosae 5g, Fructus Hippophae 10g, Fructus Rosae Normalis 10g, Fructus Mori 10g, Fructus Rubi 10g.
Test 4 groups: Colla Corii Asini 4.5g, Radix Ginseng 5g, Flos Rosae Rugosae 4.5g, Fructus Hippophae 8.5g, Fructus Rosae Normalis 10g, Fructus Mori 10g, Fructus Rubi 9g.
Test 5 groups: Colla Corii Asini 5.5g, Radix Ginseng 6g, Flos Rosae Rugosae 5g, Fructus Hippophae 11g, Fructus Rosae Normalis 10.5g, Fructus Mori 10.5g, Fructus Rubi 12g.
Prepared by test raw material: taking above-mentioned Chinese medicine, addition raw material weight 10 times, concentration are 30% ethanol extraction, extract 3 times, each 2 hours, united extraction liquid, concentrate drying, and dried object adds in 1000ml deionized water, prepares into test suspension.
Test method: taking mice 70, random packet becomes 7 groups, is hypoimmunity by mice modeling, normal group not modeling, and modeling successfully starts administration, and matched group gives normal saline 0.2ml/20g.Administration 1-5 group gastric infusion, dosage 20ml/kg, successive administration 30 days, 24 hours broken end sacrificed by exsanguination mices after drug withdrawal, aseptically take out spleen, make splenocyte suspension with RPMI-1640 (containing 10% calf serum), mouse boosting cell is adjusted to 5 × 106Cell/ml, is added in 96 well culture plates, every hole 100 μ l, and each hole adds double (namely adds ConA, and is not added with ConA).ConA20 μ l (concentration is 1000 μ g/ml), RPMI-1640 80 μ l, be every hole to 200 μ l volumes, in 5%CO2Cultivating 72 hours in 37 DEG C of calorstats, terminate cultivating first 24 hours, every hole adds 3H-TdR3.7 × 109(iucr).Cell is collected in 49 type glass fiber filter paper with cell harvestor (TITERTEKCELLHARVESTER550), successively with distilled water, 5% triamine acetic acid, absolute ethanol washing, filter paper is placed in 60 DEG C of incubators and dries, it is added in the cup containing 5ml scintillation solution, survey through liquid scintillation instrument (BECKMENLS9800) and participate in radioactivity (cpm), then calculating stimulation index (SI), namely SI=adds ConA hole cpm/ and does not add ConA hole cpm.
The impact on hypoimmunity mice Splenic vein hemodynamics of the table 1 different tests medicine.
| Group | SI |
| Normal group | 0.712±0.068** |
| Matched group | 0.133±0.041 |
| Test 1 group | 2.348±0.123** |
| Test 2 groups | 2.420±0.328** |
| Test 3 groups | 3.136±0.167*** |
| Test 4 groups | 2.378±0.209** |
| Test 5 groups | 2.442±0.194** |
Note: compare * * p < 0.01, * * * P < 0.001 with matched group.
Test example 2 mouse anti-reflecting fatigue is tested
Experimental animal: Kunming mouse, body weight 18-20g.
Trial drug:
Test 1 group: Colla Corii Asini 4g, Radix Ginseng 4g, Flos Rosae Rugosae 4g, Fructus Hippophae 8g, Fructus Rosae Normalis 8g, Fructus Mori 8g, Fructus Rubi 8g.
Test 2 groups: Colla Corii Asini 6g, Radix Ginseng 6g, Flos Rosae Rugosae 6g, Fructus Hippophae 12g, Fructus Rosae Normalis 12g, Fructus Mori 12g, Fructus Rubi 12g.
Test 3 groups: Colla Corii Asini 5g, Radix Ginseng 5g, Flos Rosae Rugosae 5g, Fructus Hippophae 10g, Fructus Rosae Normalis 10g, Fructus Mori 10g, Fructus Rubi 10g.
Test 4 groups: Colla Corii Asini 4.5g, Radix Ginseng 5g, Flos Rosae Rugosae 4.5g, Fructus Hippophae 8.5g, Fructus Rosae Normalis 10g, Fructus Mori 10g, Fructus Rubi 9g.
Test 5 groups: Colla Corii Asini 5.5g, Radix Ginseng 6g, Flos Rosae Rugosae 5g, Fructus Hippophae 11g, Fructus Rosae Normalis 10.5g, Fructus Mori 10.5g, Fructus Rubi 12g.
Prepared by test raw material: taking above-mentioned Chinese medicine, addition raw material weight 10 times, concentration are 30% ethanol extraction, extract 3 times, each 2 hours, united extraction liquid, concentrate drying, and dried object adds in 1000ml deionized water, prepares into test suspension.
Test method: taking mice 60, random packet becomes 6 groups, and matched group gives normal saline 0.2ml/20g.Administration 1-5 group gastric infusion, dosage 20ml/kg, after being administered 1 hour, quickly mice is put into the swimming pool got ready in advance, record mice enters pond to start to the time no longer swum.Result is in Table 2.
Table 2 anti-fatigue test result
| Group | Swimming time (min) |
| Matched group | 2.3±0.7 |
| Test 1 group | 8.2±0.2** |
| Test 2 groups | 8.4±0.6** |
| Test 3 groups | 11.1±0.4*** |
| Test 4 groups | 8.6±0.8** |
| Test 5 groups | 8.1±0.7** |
Note: compare * * p < 0.01, * * * P < 0.001 with matched group.
Test 3 is enriched blood test
Experimental animal: thing SPF level kunming mice, female, body weight (20 ± 2) g.
Trial drug:
Test 1 group: Colla Corii Asini 4g, Radix Ginseng 4g, Flos Rosae Rugosae 4g, Fructus Hippophae 8g, Fructus Rosae Normalis 8g, Fructus Mori 8g, Fructus Rubi 8g.
Test 2 groups: Colla Corii Asini 6g, Radix Ginseng 6g, Flos Rosae Rugosae 6g, Fructus Hippophae 12g, Fructus Rosae Normalis 12g, Fructus Mori 12g, Fructus Rubi 12g.
Test 3 groups: Colla Corii Asini 5g, Radix Ginseng 5g, Flos Rosae Rugosae 5g, Fructus Hippophae 10g, Fructus Rosae Normalis 10g, Fructus Mori 10g, Fructus Rubi 10g.
Test 4 groups: Colla Corii Asini 4.5g, Radix Ginseng 5g, Flos Rosae Rugosae 4.5g, Fructus Hippophae 8.5g, Fructus Rosae Normalis 10g, Fructus Mori 10g, Fructus Rubi 9g.
Test 5 groups: Colla Corii Asini 5.5g, Radix Ginseng 6g, Flos Rosae Rugosae 5g, Fructus Hippophae 11g, Fructus Rosae Normalis 10.5g, Fructus Mori 10.5g, Fructus Rubi 12g.
Prepared by test raw material: taking above-mentioned Chinese medicine, addition raw material weight 10 times, concentration are 30% ethanol extraction, extract 3 times, each 2 hours, united extraction liquid, concentrate drying, and dried object adds in 1000ml deionized water, prepares into test suspension.
Test method: SPF level kunming mice 70, is randomly divided into 7 groups: blank group, model group, trial drug group, often organizes each 10.Gastric infusion, dosage is dosage 20ml/kg, except normal group, 1d is by tail venesection for other groups: wipe mouse tail vein with 75% hot alcohol, cutting tail in far-end, juxtaposition fills and controls blood-letting amount, 0.25mL/10g in the graduated test tube of normal saline (37 DEG C), survey erythrocyte (redblood-cellcount, RBC) simultaneously.Lose blood and take blood again through orbital vein after 24h and survey RBC, and see that pallor, the phenomenon of a series of traditional Chinese medical science blood deficiency diseases such as inappetence occurs in mice.After modeling, 2d starts administration, and continuous 7d, 8d respectively organize mouse orbit venous blood collection, detect its RBC.
Result of the test: in Table 3.
The table 3 impact on blood deficiency mice RBC
Note: compare * * P < 0.01 with model group.
Preparation embodiment
Embodiment 1
Preparation is prepared into by following raw material Colla Corii Asini 40g, Radix Ginseng 40g, Flos Rosae Rugosae 40g, Fructus Hippophae 80g, Fructus Rosae Normalis 80g, Fructus Mori 80g, Fructus Rubi 80g.
Taking raw material, add raw material weight 8 times, concentration 30% ethanol, extract 3 times, extract 2 hours, united extraction liquid every time, filter, filtrate concentrate drying, dried object adds adjuvant and prepares into 100, tablet.
Or take Radix Ginseng, Flos Rosae Rugosae, Fructus Hippophae, Fructus Rosae Normalis, Fructus Mori, Fructus Rubi first to soak 10 hours with claret 6000ml, filter, standby；Colla Corii Asini is used purified water molten, obtains Colla Corii Asini liquid, standby；Finally Colla Corii Asini liquid, blue berry concentrated juice 200ml and xylitol 320g, aspartame 0.95g being joined in above-mentioned wine, stir, filter, inject water to 10000ml, fill is to 750ml bottle.
Embodiment 2
Preparation is prepared into by following raw material Colla Corii Asini 60g, Radix Ginseng 60g, Flos Rosae Rugosae 60g, Fructus Hippophae 120g, Fructus Rosae Normalis 120g, Fructus Mori 120g, Fructus Rubi 120g.
Taking raw material, add raw material weight 8 times, concentration 30% ethanol, extract 3 times, extract 2 hours, united extraction liquid every time, filter, filtrate concentrate drying, dried object adds adjuvant and prepares into 100, tablet.
Or take Radix Ginseng, Flos Rosae Rugosae, Fructus Hippophae, Fructus Rosae Normalis, Fructus Mori, Fructus Rubi first to soak 10 hours with claret 6000ml, filter, standby；Colla Corii Asini is used purified water molten, obtains Colla Corii Asini liquid, standby；Finally Colla Corii Asini liquid, blue berry concentrated juice 200ml and xylitol 320g, aspartame 0.95g being joined in above-mentioned wine, stir, filter, inject water to 10000ml, fill is to 750ml bottle.
Embodiment 3
Preparation is prepared into by following raw material Colla Corii Asini 50g, Radix Ginseng 50g, Flos Rosae Rugosae 50g, Fructus Hippophae 100g, Fructus Rosae Normalis 100g, Fructus Mori 100g, Fructus Rubi 100g.
Taking raw material, add raw material weight 8 times, concentration 30% ethanol, extract 3 times, extract 2 hours, united extraction liquid every time, filter, filtrate concentrate drying, dried object adds adjuvant and prepares into capsule 100.
Or take Radix Ginseng, Flos Rosae Rugosae, Fructus Hippophae, Fructus Rosae Normalis, Fructus Mori, Fructus Rubi first to soak 10 hours with claret 6000ml, filter, standby；Colla Corii Asini is used purified water molten, obtains Colla Corii Asini liquid, standby；Finally Colla Corii Asini liquid, blue berry concentrated juice 200ml and xylitol 320g, aspartame 0.95g being joined in above-mentioned wine, stir, filter, inject water to 10000ml, fill is to 750ml bottle.
Embodiment 4
Preparation is prepared into by following raw material Colla Corii Asini 45g, Radix Ginseng 50g, Flos Rosae Rugosae 45g, Fructus Hippophae 85g, Fructus Rosae Normalis 100g, Fructus Mori 100g, Fructus Rubi 90g.
Taking raw material, add raw material weight 8 times, concentration 30% ethanol, extract 3 times, extract 2 hours, united extraction liquid every time, filter, filtrate concentrate drying, dried object adds adjuvant and prepares into capsule 100.
Or take Radix Ginseng, Flos Rosae Rugosae, Fructus Hippophae, Fructus Rosae Normalis, Fructus Mori, Fructus Rubi first to soak 10 hours with claret 6000ml, filter, standby；Colla Corii Asini is used purified water molten, obtains Colla Corii Asini liquid, standby；Finally Colla Corii Asini liquid, blue berry concentrated juice 200ml and xylitol 320g, aspartame 0.95g being joined in above-mentioned wine, stir, filter, inject water to 10000ml, fill is to 750ml bottle.
Embodiment 5
Preparation is prepared into by following raw material Colla Corii Asini 55g, Radix Ginseng 60g, Flos Rosae Rugosae 50g, Fructus Hippophae 110g, Fructus Rosae Normalis 105g, Fructus Mori 105g, Fructus Rubi 120g.
Taking raw material, add raw material weight 8 times, concentration 30% ethanol, extract 3 times, extract 2 hours, united extraction liquid every time, filter, filtrate concentrate drying, dried object adds adjuvant and prepares into capsule 100.
Or take Radix Ginseng, Flos Rosae Rugosae, Fructus Hippophae, Fructus Rosae Normalis, Fructus Mori, Fructus Rubi first to soak 10 hours with claret 6000ml, filter, standby；Colla Corii Asini is used purified water molten, obtains Colla Corii Asini liquid, standby；Finally Colla Corii Asini liquid, blue berry concentrated juice 200ml and xylitol 320g, aspartame 0.95g being joined in above-mentioned wine, stir, filter, inject water to 10000ml, fill is to 750ml bottle.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.
Claims (9)
1. a pharmaceutical composition, it is characterised in that pharmaceutical composition prepares into pharmaceutical preparation, its pharmaceutical formulations is prepared from by following raw material: Colla Corii Asini, Radix Ginseng, Flos Rosae Rugosae, Fructus Hippophae, Fructus Rosae Normalis, Fructus Mori, Fructus Rubi.
2. a kind of pharmaceutical composition according to claim 1, wherein Colla Corii Asini 4-6 weight portion, Radix Ginseng 4-6 weight portion, Flos Rosae Rugosae 4-6 weight portion, Fructus Hippophae 8-12 weight portion, Fructus Rosae Normalis 8-12 weight portion, Fructus Mori 8-12 weight portion, Fructus Rubi 8-12 weight portion.
3. a kind of pharmaceutical composition according to claim 1, wherein Colla Corii Asini 5 weight portion, Radix Ginseng 5 weight portion, Flos Rosae Rugosae 5 weight portion, Fructus Hippophae 10 weight portion, Fructus Rosae Normalis 10 weight portion, Fructus Mori 10 weight portion, Fructus Rubi 10 weight portion.
4. a kind of pharmaceutical composition according to any one of claim 1-3, it is characterised in that pharmaceutical composition improves the application in immunity medicine or food in preparation.
5. a kind of pharmaceutical composition according to any one of claim 1-3, it is characterised in that pharmaceutical composition application in preparation medicament for enriching blood or food.
6. a kind of pharmaceutical composition according to any one of claim 1-3, it is characterised in that pharmaceutical composition application in preparing anti-fatigue medicament or food.
7. a kind of pharmaceutical composition according to claim 1, its pharmaceutical formulations includes oral formulations.
8. a kind of pharmaceutical composition according to claim 1, its pharmaceutical formulations includes medicated wine.
9. a kind of pharmaceutical composition according to claim 8, wherein the preparation method of medicated wine is:
Take Radix Ginseng, Flos Rosae Rugosae, Fructus Hippophae, Fructus Rosae Normalis, Fructus Mori, Fructus Rubi first to soak 6-18 hour with claret, filter, standby；Colla Corii Asini is used purified water molten, obtains Colla Corii Asini liquid, standby；Finally Colla Corii Asini liquid, blue berry concentrated juice and xylitol, aspartame are joined in above-mentioned wine, stir, filter, fill, outer package, inspection, warehouse-in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610144586.8A CN105770078B (en) | 2016-03-13 | 2016-03-13 | Pharmaceutical composition, preparation and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610144586.8A CN105770078B (en) | 2016-03-13 | 2016-03-13 | Pharmaceutical composition, preparation and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105770078A true CN105770078A (en) | 2016-07-20 |
| CN105770078B CN105770078B (en) | 2020-11-06 |
Family
ID=56393146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610144586.8A Active CN105770078B (en) | 2016-03-13 | 2016-03-13 | Pharmaceutical composition, preparation and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105770078B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107811168A (en) * | 2016-09-14 | 2018-03-20 | 北京宝得瑞健康产业有限公司 | A kind of eye-protecting function beverage and preparation method thereof |
| CN110115386A (en) * | 2019-06-17 | 2019-08-13 | 山东欣希安药业股份有限公司 | A kind of alimentation composition and preparation method thereof improving ovarian function |
| CN114404535A (en) * | 2020-10-28 | 2022-04-29 | 四川省中医药科学院 | Pharmaceutical composition for relieving cancer-induced fatigue and chronic fatigue syndrome, preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660408A (en) * | 2003-12-31 | 2005-08-31 | 赵恒� | Medicine to be taken after being mixed in liquor of possessing bearutified and-faced effects |
| CN102329715A (en) * | 2011-09-20 | 2012-01-25 | 成都圣弘源科贸有限公司 | Compound Rhodiola rosea wine and preparation method thereof |
| CN103725575A (en) * | 2014-01-22 | 2014-04-16 | 雷正新 | Bagged preparation of health care wine and preparation method thereof |
-
2016
- 2016-03-13 CN CN201610144586.8A patent/CN105770078B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660408A (en) * | 2003-12-31 | 2005-08-31 | 赵恒� | Medicine to be taken after being mixed in liquor of possessing bearutified and-faced effects |
| CN102329715A (en) * | 2011-09-20 | 2012-01-25 | 成都圣弘源科贸有限公司 | Compound Rhodiola rosea wine and preparation method thereof |
| CN103725575A (en) * | 2014-01-22 | 2014-04-16 | 雷正新 | Bagged preparation of health care wine and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107811168A (en) * | 2016-09-14 | 2018-03-20 | 北京宝得瑞健康产业有限公司 | A kind of eye-protecting function beverage and preparation method thereof |
| CN110115386A (en) * | 2019-06-17 | 2019-08-13 | 山东欣希安药业股份有限公司 | A kind of alimentation composition and preparation method thereof improving ovarian function |
| CN114404535A (en) * | 2020-10-28 | 2022-04-29 | 四川省中医药科学院 | Pharmaceutical composition for relieving cancer-induced fatigue and chronic fatigue syndrome, preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105770078B (en) | 2020-11-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104208302A (en) | Fructus rosae laevigatae healthy oral solution for reducing blood fat and preparation method thereof | |
| CN105770078A (en) | Pharmaceutical composition as well as preparation and application thereof | |
| CN103599424B (en) | A kind of Chinese medicine composition for skin whitening | |
| CN103462855B (en) | Cosmetic containing American ginseng and longan and preparation method thereof | |
| CN105125946A (en) | Gardenia oral liquid clearing away heart fire and relieving restlessness and preparing method thereof | |
| CN104107348A (en) | Chinese herbal medicine for blood sugar reducing, and administration method thereof | |
| CN105434738A (en) | Traditional Chinese medicine composition for treating ADHD (Attention Deficit Hyperactivity Disorder) and preparation method thereof | |
| CN106474447A (en) | A kind of antagonism head infection, compositionss of antipruritic anticreep and its preparation method and application | |
| CN101249255B (en) | Proprietary Chinese medicine for curing children's cough and method of preparing the same | |
| CN102919452A (en) | Throat clearing and nourishing tea and preparation method thereof | |
| CN105250989A (en) | Donkey-hide glue small peptide composition for resisting fatigue | |
| CN104147038A (en) | Fungal polysaccharide and composition thereof with anti-gastric ulcer effects | |
| CN101381667B (en) | Preparation method of pilose antler blood alcohol | |
| KR101048939B1 (en) | Method for producing product for promoting hair growth | |
| CN106177082A (en) | A kind of preparation method and application of compound phellodendron bark liquid varnish | |
| CN102488063B (en) | Health preserving jujube containing Saussurea involucrata and preparation method thereof | |
| CN104383243A (en) | Traditional Chinese medicine liquor with effects of enhancing blood vessels, tonifying qi and maintaining health and preparation method thereof | |
| CN101129604B (en) | Antihypelipidemic traditional Chinese medicine producing method | |
| CN104383265A (en) | Codonopsis pilosulae-ginseng traditional Chinese medicine wine for tonifying qi and preserving health and preparation method of codonopsis pilosulae-ginseng traditional Chinese medicine wine | |
| CN108815268A (en) | A kind of external application promotees the Chinese medicine ointment formulation and preparation method thereof of union of wounded skin | |
| CN104523985A (en) | Cordyceps health-preservation traditional Chinese medicine liquor and preparation method thereof | |
| CN110025685B (en) | A liquid preparation containing propolis composition | |
| CN105168432A (en) | Pharmaceutical composition for promoting fracture repair | |
| CN106520425A (en) | Female blood-replenishing healthcare wine | |
| CN102100814A (en) | Method for preparing nanometer traditional Chinese medicine for treating severe asthma and production method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |