CN105473714A - 遗传不育动物 - Google Patents

遗传不育动物 Download PDF

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Publication number
CN105473714A
CN105473714A CN201480042269.4A CN201480042269A CN105473714A CN 105473714 A CN105473714 A CN 105473714A CN 201480042269 A CN201480042269 A CN 201480042269A CN 105473714 A CN105473714 A CN 105473714A
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China
Prior art keywords
gene
animal
cells
cell
sperm
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Pending
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CN201480042269.4A
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English (en)
Chinese (zh)
Inventor
D.F.卡尔森
S.C.法伦克鲁格
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Recombinetics Inc
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Recombinetics Inc
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0273—Cloned vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A01K2217/077—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out heterozygous knock out animals displaying phenotype
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/103—Ovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
CN201480042269.4A 2013-05-31 2014-04-29 遗传不育动物 Pending CN105473714A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361829656P 2013-05-31 2013-05-31
US61/829,656 2013-05-31
US201361870558P 2013-08-27 2013-08-27
US61/870,558 2013-08-27
PCT/US2014/035847 WO2014193583A2 (en) 2013-05-31 2014-04-29 Genetically sterile animals

Publications (1)

Publication Number Publication Date
CN105473714A true CN105473714A (zh) 2016-04-06

Family

ID=51986779

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480042269.4A Pending CN105473714A (zh) 2013-05-31 2014-04-29 遗传不育动物

Country Status (13)

Country Link
US (2) US20140359796A1 (https=)
EP (1) EP3004345A4 (https=)
JP (1) JP2016525890A (https=)
KR (1) KR20160013219A (https=)
CN (1) CN105473714A (https=)
AP (1) AP2015008963A0 (https=)
AU (1) AU2014272106A1 (https=)
BR (1) BR112015029904A2 (https=)
CA (1) CA2913411A1 (https=)
MX (1) MX2015016385A (https=)
PH (1) PH12015502640A1 (https=)
RU (1) RU2015156801A (https=)
WO (1) WO2014193583A2 (https=)

Cited By (9)

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CN109837347A (zh) * 2019-01-02 2019-06-04 华中农业大学 Catsper4基因第三外显子的snp作为猪精液品质性状的遗传标记
CN110184296A (zh) * 2018-02-07 2019-08-30 上海大学 一种制备雌雄均高度不育的鳞翅目昆虫的方法及其核酸构建物
CN111549032A (zh) * 2020-05-26 2020-08-18 肇庆学院 一种诱导型精原细胞Tubb4b基因敲除细胞系的构建方法
CN111787791A (zh) * 2018-02-26 2020-10-16 Ag遗传学股份有限公司 用于防止特定染色体的传播的材料和方法
CN111867373A (zh) * 2017-12-18 2020-10-30 Imv技术股份有限公司 使用slo3钾通道抑制剂提高动物精子寿命和运动力的方法
CN116064541A (zh) * 2022-10-21 2023-05-05 华南农业大学 一种基于CRISPR/Cas9系统敲除猪细胞Y染色体的方法
CN116884488A (zh) * 2023-09-07 2023-10-13 中国医学科学院基础医学研究所 一种男性不育标志物的筛查方法、系统及设备
CN117545350A (zh) * 2020-12-31 2024-02-09 以色列农业和农村发展部农业研究组织(沃尔卡尼研究所) 不育禽类胚胎、其产生及用途
CN118910165A (zh) * 2024-10-11 2024-11-08 上海南方模式生物科技股份有限公司 一种cxcl16基因人源化动物模型的构建方法及应用

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CN110214183A (zh) 2016-08-03 2019-09-06 哈佛大学的校长及成员们 腺苷核碱基编辑器及其用途
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KR102622411B1 (ko) 2016-10-14 2024-01-10 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵염기 에디터의 aav 전달
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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111867373A (zh) * 2017-12-18 2020-10-30 Imv技术股份有限公司 使用slo3钾通道抑制剂提高动物精子寿命和运动力的方法
CN111867373B (zh) * 2017-12-18 2023-05-02 Imv技术股份有限公司 使用slo3钾通道抑制剂提高动物精子寿命和运动力的方法
CN110184296A (zh) * 2018-02-07 2019-08-30 上海大学 一种制备雌雄均高度不育的鳞翅目昆虫的方法及其核酸构建物
CN110184296B (zh) * 2018-02-07 2023-06-09 上海大学 一种制备雌雄均高度不育的鳞翅目昆虫的方法及其核酸构建物
CN111787791A (zh) * 2018-02-26 2020-10-16 Ag遗传学股份有限公司 用于防止特定染色体的传播的材料和方法
CN109837347B (zh) * 2019-01-02 2021-01-29 华中农业大学 Catsper4基因第三外显子的snp作为猪精液品质性状的遗传标记
CN109837347A (zh) * 2019-01-02 2019-06-04 华中农业大学 Catsper4基因第三外显子的snp作为猪精液品质性状的遗传标记
CN111549032A (zh) * 2020-05-26 2020-08-18 肇庆学院 一种诱导型精原细胞Tubb4b基因敲除细胞系的构建方法
CN117545350A (zh) * 2020-12-31 2024-02-09 以色列农业和农村发展部农业研究组织(沃尔卡尼研究所) 不育禽类胚胎、其产生及用途
CN116064541A (zh) * 2022-10-21 2023-05-05 华南农业大学 一种基于CRISPR/Cas9系统敲除猪细胞Y染色体的方法
CN116884488A (zh) * 2023-09-07 2023-10-13 中国医学科学院基础医学研究所 一种男性不育标志物的筛查方法、系统及设备
CN116884488B (zh) * 2023-09-07 2023-11-24 中国医学科学院基础医学研究所 一种男性不育标志物的筛查方法、系统及设备
CN118910165A (zh) * 2024-10-11 2024-11-08 上海南方模式生物科技股份有限公司 一种cxcl16基因人源化动物模型的构建方法及应用

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US20190335725A1 (en) 2019-11-07
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AU2014272106A1 (en) 2016-01-21
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PH12015502640A1 (en) 2016-03-07

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