CN105456718A - 一种治疗放射性皮炎的膏剂及制备 - Google Patents
一种治疗放射性皮炎的膏剂及制备 Download PDFInfo
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Abstract
本发明涉及一种治疗放射性皮炎的膏剂及制备，其特征在于原料药提取物的重量百分比如下：天花粉6-10％、水蛭0.5-2％、白及3-6％、毛诃子3～9％、丁香罗勒油5-10％、王不留行2-3％、鸦胆子0.5～2％。本发明有益效果是：具有提高皮肤抗辐射能力、改善局部循环、解毒、生肌，促进皮肤黏膜修复。
Description
技术领域
本发明涉及一种治疗放射性皮炎的膏剂及制备。
背景技术
众所周知，放射性皮炎常见肿瘤患者放疗或做职业性放射工作人员或接受放射性治疗的患者。受电离辐射引起的皮肤损伤。均称放射性皮炎，临床表现：I度为皮肤干燥、色素沉着或脱失、粗糙，指甲灰暗或纵嵴色条甲；II度为皮肤角化过度、皲裂或萎缩变薄，毛细血管扩张，指甲增厚变形等；III度为坏死溃疡、角质突起、指端角化融合、肌腱挛缩、关节变形、功能障碍等。受到慢性辐射损伤，皮肤可发生扁平或疣状有质增生，或形成顽固性溃疡，可继发基底细胞癌或鳞癌。目前治疗没有有效药物，只是对症治疗。
发明内容
本发明的目的是为了解决上述技术上的不足，提供该药吸收率高、副作用少、治愈率高，成本低且无毒副作用的一种治疗电离辐射性皮炎的膏剂及制备。
本发明有益效果是：具有提高皮肤抗辐射能力、改善局部循环、解毒、生肌，促进皮肤黏膜修复。通过临床常根据不同证型辨证施治。
为实现上述目的，一种治疗放射性皮炎的膏剂及制备，其特征在于原料药提取物的重量百分比如下：天花粉6-10％、水蛭0.5-2％、白及3-6％、毛诃子3～9％、丁香罗勒油5-10％、王不留行2-3％、鸦胆子0.5～2％。
制备方法：将王不留行、鸦胆子去壳备用。将水蛭取净水蛭段，按常规照烫法，用滑石粉烫至微鼓起，然后水飞30分钟，滤液滤过，备用。将毛诃子加乙醚按1∶10，振摇提取30分钟，弃去乙醚，药渣挥干，加醋酸乙酯按1∶10，加热回流1小时，放冷，滤过，备用。以上残渣与白及、去壳的王不留行和鸦胆子加水比例1∶10进行加热回流2次，按2∶1小时，合并2次滤液，滤过。再将以上滤液合并，加天花粉搅匀，加丁香罗勒油混匀，浓缩至相对密度为1.25(60℃)的清膏。即得。
本发明中药中的天花粉，本品为葫芦科植物栝楼TrichosantheskirilowiiMaxim.或双边栝楼Trichosan-thesrosthorniiHerms的干燥根。性味与归经：甘、微苦，微寒。功能与主治：清热生津，消肿排脓。水蛭，本品为水蛭科动物蚂蟥WhitmaniapigraWhitman、水蛭HirudonipponicaWhitman或柳叶蚂蟥Whit-mania。acranulataWhitman的干燥体。性味与归经：咸、苦，平；归肝经。功能与主治：破血，逐瘀，通经。用于癥瘕痞块，血瘀经闭，跌扑损伤。白及，品为兰科植物白及Bletillastriata(Thunb.)Reichb.f.的干燥块茎。性味与归经：苦、甘、涩，微寒。功能与主治：收敛止血，消肿生肌。用于咳血吐血，外伤出血，疮疡肿毒，皮肤皲裂；肺结核咳血，溃疡病出血。诃子系藏族习用药材，为使君子科植物毗黎勒Terminaliabillerica(Gaertn.)Roxb.的干燥成熟果实。性味：甘、涩，平。能与主治：清热解毒，收敛养血，调和诸药。用于各种热症，泻痢，黄水病，肝胆病，病后虚弱。丁香罗勒油本品为唇形科植物丁香罗勒OcimumgratissimumL.的全草经水蒸气蒸馏得到的挥发油。含丁香酚(C10H12O2)功能与主治：镇痛、防腐。鸦胆子本品为苦木科植物鸦胆子Bruceajavanica(L.)Merr.的干燥成熟果实。性味与归经：苦，寒；有小毒。功能与主治：清热解毒，截疟，止痢，腐蚀赘疣。王不留行本品为石竹科植物麦蓝菜Vaccariasegetalis(Neck.)Garcke的干燥成熟种子。性味与归经：苦，平。归肝、胃经。功能与主治：活血通经，下乳消肿。以上药物配伍，相得益彰。
本发明遵循中医的处方用药原则，本发明经临床验证：有效率在90％以上，治愈率为80％以上，无毒副作用。
具体实施方式
下面结合实施病例对本发明作进一步描述：
实施例1：一种治疗放射性皮炎的膏剂及制备，其特征在于原料药提取物的重量百分比如下：天花粉6-10％、水蛭0.5-2％、白及3-6％、毛诃子3～9％、丁香罗勒油5-10％、王不留行2-3％、鸦胆子0.5～2％。制备工艺同上，即得流膏。
实施例2：一种治疗放射性皮炎的膏剂及制备，其特征在于原料药提取物的重量百分比如下：天花粉10％、水蛭2％、白及6％、毛诃子9％、丁香罗勒油0％、王不留行3％、鸦胆子1％。制备工艺同上，即得流膏。制备工艺同实施例1，即得流膏100g。
临床疗效总结：
一、本方多年来在临床应用广泛，治疗上百例患者，疗效频佳。使用注意：孕妇、月经过多者忌用。
二、诊断依据：有放射史，临床表现：I度为皮肤干燥、色素沉着或脱失、粗糙，指甲灰暗或纵嵴色条甲；II度为皮肤角化过度、皲裂或萎缩变薄，毛细血管扩张，指甲增厚变形等；III度为坏死溃疡、角质突起、指端角化融合、肌腱挛缩、关节变形、功能障碍等。受到慢性放射性损伤，皮肤可发生扁平或疣状有质增生，或形成顽固性溃疡，可继发基底细胞癌或鳞癌。
三、用药方法：每次10g，每日早、外敷患处，10日为1疗程。
四、疗效评定：
治愈：临床症状完全消失。
好转：临床症状减轻。
未愈：症状和体征无明显改善。
五、治疗效果：本发明中药治疗本病，经统计治愈率在85％以上，有效率90％以上。
六、典型病例：
1.李XX，女，30岁。2012年8月就诊。主诉行乳腺癌根治术，放疗2周后出现腋窝黏膜发红、水肿；糜烂。经消炎药膏不见效果。经患者要求用本发明中药膏剂1个疗程，临床症状完全消失，半年后随访未再复发。
2.王XX，女，35岁。2014年11月就诊。主诉行肺癌手术，放疗3周后出现左胸部黏膜发红、水肿；糜烂。经消炎药膏不见效果。经患者要求用本发明中药膏剂1个疗程，临床症状完全消失，半年后随访未再复发。
3.李XX，男，42岁。2015年1月就诊。主诉头颅肿瘤术后放疗1个月。头皮黏膜发红、水肿，逐渐色暗。患者要求用本发明中药膏剂3个疗程，临床症状完全消失，半年后随访未再复发。
Claims (2)
1.一种治疗放射性皮炎的膏剂，其特征在于原料药提取物的重量百分比如下：天花粉6-10％、水蛭0.5-2％、白及3-6％、毛诃子3～9％、丁香罗勒油5-10％、王不留行2-3％、鸦胆子0.5～2％。
2.根据权利要求1一种治疗放射性皮炎的膏剂及制备，其特征是先将王不留行、鸦胆子去壳备用。再将水蛭取净水蛭段，按常规照烫法，用滑石粉烫至微鼓起，然后水飞30分钟，滤液滤过，备用。将毛诃子加乙醚按1∶10，振摇提取30分钟，弃去乙醚，药渣挥干，加醋酸乙酯按1∶10，加热回流1小时，放冷，滤过，备用。以上残渣与白及、去壳的王不留行和鸦胆子加水比例1∶10进行加热回流2次，按2∶1小时，合并2次滤液，滤过。再将以上滤液合并，加天花粉搅匀，加丁香罗勒油混匀，浓缩至相对密度为1.25(60℃)的清膏。即得。
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| CN113827557B (zh) * | 2021-11-18 | 2024-01-26 | 河南中医药大学 | 一种防治放射性皮炎的中药膏 |
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