CN105452295B - 抗血液树突细胞抗原2抗体及其用途 - Google Patents
抗血液树突细胞抗原2抗体及其用途 Download PDFInfo
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- CN105452295B CN105452295B CN201380071162.8A CN201380071162A CN105452295B CN 105452295 B CN105452295 B CN 105452295B CN 201380071162 A CN201380071162 A CN 201380071162A CN 105452295 B CN105452295 B CN 105452295B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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- A—HUMAN NECESSITIES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Proteomics, Peptides & Aminoacids (AREA)
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- Genetics & Genomics (AREA)
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- Rheumatology (AREA)
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- Obesity (AREA)
- Dermatology (AREA)
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- Emergency Medicine (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010418430.0A CN111961134B (zh) | 2012-12-10 | 2013-12-10 | 抗血液树突细胞抗原2抗体及其用途 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261735362P | 2012-12-10 | 2012-12-10 | |
| US61/735,362 | 2012-12-10 | ||
| US201361763270P | 2013-02-11 | 2013-02-11 | |
| US61/763,270 | 2013-02-11 | ||
| PCT/US2013/074208 WO2014093396A1 (en) | 2012-12-10 | 2013-12-10 | Anti-blood dendritic cell antigen 2 antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010418430.0A Division CN111961134B (zh) | 2012-12-10 | 2013-12-10 | 抗血液树突细胞抗原2抗体及其用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105452295A CN105452295A (zh) | 2016-03-30 |
| CN105452295B true CN105452295B (zh) | 2020-06-12 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380071162.8A Active CN105452295B (zh) | 2012-12-10 | 2013-12-10 | 抗血液树突细胞抗原2抗体及其用途 |
| CN202010418430.0A Active CN111961134B (zh) | 2012-12-10 | 2013-12-10 | 抗血液树突细胞抗原2抗体及其用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010418430.0A Active CN111961134B (zh) | 2012-12-10 | 2013-12-10 | 抗血液树突细胞抗原2抗体及其用途 |
Country Status (25)
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| EP (2) | EP3686218A1 (enExample) |
| JP (4) | JP6490591B2 (enExample) |
| KR (2) | KR102344907B1 (enExample) |
| CN (2) | CN105452295B (enExample) |
| AU (1) | AU2013359419B2 (enExample) |
| BR (1) | BR122020023058B1 (enExample) |
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| IL (2) | IL238804B (enExample) |
| LT (1) | LT2928923T (enExample) |
| MX (1) | MX363407B (enExample) |
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| PT (1) | PT2928923T (enExample) |
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| SM (1) | SMT202000193T1 (enExample) |
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| ZA (1) | ZA201503881B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024140838A1 (zh) | 2022-12-28 | 2024-07-04 | 映恩生物制药(苏州)有限公司 | 抗bdca2抗体-药物偶联物及其用途 |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2968561B1 (fr) † | 2010-12-13 | 2013-08-09 | Lfb Biotechnologies | Utilisation d'un anticorps dirige contre une proteine membranaire |
| AU2014365838B2 (en) | 2013-12-16 | 2021-01-14 | The University Of North Carolina At Chapel Hill | Depletion of plasmacytoid dendritic cells |
| CN109535254B (zh) | 2013-12-24 | 2022-06-24 | 安斯泰来制药株式会社 | 抗人bdca-2抗体、其生产方法、多核苷酸、表达载体、宿主细胞及医药组合物 |
| FR3034420A1 (fr) | 2015-03-31 | 2016-10-07 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-cd303 |
| FR3045386B1 (fr) | 2015-12-16 | 2018-02-02 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Nouvelle utilisation d'un anticorps dirige contre une proteine membranaire |
| CN116850282A (zh) * | 2016-04-28 | 2023-10-10 | 渤健马萨诸塞州股份有限公司 | 用于临床使用抗血树突细胞抗原2抗体的药物组合物和给药方案 |
| CN110129298B (zh) * | 2016-06-02 | 2021-08-03 | 天津科技大学 | 一种磷脂酶d突变体及其应用 |
| CN110709417B (zh) * | 2017-04-07 | 2023-10-31 | 美天施生物科技有限责任两合公司 | 具有突变人IgG4的多肽 |
| WO2019210034A1 (en) * | 2018-04-27 | 2019-10-31 | Advaxis, Inc. | Compositions and methods for evaluating potency of listeria-based immunotherapeutics |
| CN119080931A (zh) * | 2018-06-04 | 2024-12-06 | 马萨诸塞州渤健公司 | 具有降低的效应功能的抗vla-4抗体 |
| US12410225B2 (en) | 2018-11-08 | 2025-09-09 | Orionis Biosciences, Inc | Modulation of dendritic cell lineages |
| MX2022001604A (es) * | 2019-08-05 | 2022-07-19 | Capella Bioscience Ltd | Anticuerpos anti bdca-2. |
| IL303279A (en) * | 2020-12-03 | 2023-07-01 | Biogen Ma Inc | Methods of treating cutaneous lupus erythematosus and systemic lupus erythematosus |
| IL303656A (en) | 2020-12-17 | 2023-08-01 | Hoffmann La Roche | Anti-hla-g antibodies and use thereof |
| CN113484512B (zh) * | 2021-06-01 | 2023-06-27 | 中国农业科学院油料作物研究所 | 黄曲霉毒素风险预警智能感知卡及其应用 |
| TW202400652A (zh) * | 2022-05-25 | 2024-01-01 | 大陸商映恩生物製藥(蘇州)有限公司 | 抗bdca2抗體及其用途 |
| WO2024010118A1 (ko) * | 2022-07-07 | 2024-01-11 | 주식회사 유틸렉스 | 항 bdca-2 항체 및 이의 용도 |
| WO2024230774A1 (en) * | 2023-05-10 | 2024-11-14 | Inmagene Biopharmaceuticals (Hangzhou) Co., Ltd. | Bdca2-targeting antibodies and uses thereof |
| CN119119267A (zh) * | 2023-06-12 | 2024-12-13 | 三生国健药业(上海)股份有限公司 | 抗bdca2抗体 |
| WO2025051083A1 (zh) * | 2023-09-05 | 2025-03-13 | 上海宏成药业有限公司 | 抗bdca-2特异性抗体及其用途 |
| WO2025091023A1 (en) * | 2023-10-27 | 2025-05-01 | Northwestern University | Engineered cell transfected by all-in-one vector for therapeutic agents production and delivery and applications thereof |
| CN120098124A (zh) * | 2023-12-05 | 2025-06-06 | 苏州普乐康医药科技有限公司 | 一种抗bdca-2抗体及其制备方法和应用 |
| CN118638234B (zh) * | 2024-07-04 | 2025-10-14 | 杭州博之锐生物制药有限公司 | 抗bdca2抗体及其制备方法和应用 |
| CN119591712B (zh) * | 2024-11-27 | 2025-11-21 | 纽迈生物科技(苏州)有限公司 | 靶向人类浆细胞样树突状细胞的单克隆抗体及其应用 |
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| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
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