CN105435249A - 一种消毒杀菌型医用超声耦合剂及其制备方法 - Google Patents
一种消毒杀菌型医用超声耦合剂及其制备方法 Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种消毒杀菌型医用超声耦合剂及其制备方法,该医用耦合剂是由以下原料药和辅料制备而成:所述原料药为:铁线透骨草、荭草根、掌裂蟹甲草、红雪柳、偏翅唐松草根、柏子仁、矮卫矛、吹风藤、粳谷奴、细叶桉、燕子尾、隆萼当归根、石荠苎、秘鲁香胶,所述辅料为:甘油、维生素E、丙二醇、邻苯基苯酚、苯乙醇。本发明组方严谨,配伍合理,具有较好的耦合作用,有杀菌消毒,润滑皮肤、活血化瘀的独特疗效,无刺激,无毒,避免了临床上超声检查的交叉感染,且成本低,易制备,对超声探头无腐蚀、气泡少,透声效果显著,超声成像清晰。
Description
技术领域
本发明涉及中药学技术领域,具体地是涉及一种消毒杀菌型医用超声耦合剂及其制备方法。
背景技术
医用超声耦合剂是一种由新一代水性高分子凝胶组成的医用产品,超声检查时,探头与病人皮肤之间的空气将阻碍超声波传入人体,为获得高质量的图像,需要液性传导介质来连接探头与病人体表,这种介质就是耦合剂。超声耦合剂使得声波传导不受空气的影响而衰减,以达到准确清洗的检查结果。它PH值为中性,对人体无毒无害,不易干燥,不易酸败,粘稠性适宜,无油腻性,探头易于滑动,可湿润皮肤,消除皮肤表面空气,润滑性好,易于展开,对超声探头无腐蚀性、无损伤。
在临床上,超声检查被广泛应用于心内科、消化内科、泌尿科和妇产科疾病的诊断,其安全性则尤为重要,但医用耦合剂和医院超声探头带菌状况令人堪优。医用超声探头频繁接触健康体检者、传染病患者、皮肤病患者、婴幼儿、孕妇等不同人群,在临床检查中存在医源性交叉感染的潜在危险;许多耦合剂的配方中含有乙醇等刺激性成分,且耦合剂是直接涂抹于皮肤上,易导致毛细血管扩张,水分容易流失,检查后患者可能会出现皮肤干燥、瘙痒,过敏反应等不适感。目前,具有消毒杀菌配方的医用超声耦合剂较少,且成分多为化学品,对身体的刺激性大,抑菌持久性差,因此研制一种快速杀菌消毒、生物相容性好、使用后皮肤舒适性高的医用耦合剂具有重要的临床意义。
发明内容
本发明为了解决现有技术的不足,提供了一种制备简单、能润滑皮肤、无刺激性的消毒杀菌型医用超声耦合剂及其制备方法。
本发明采用的技术方案为:一种消毒杀菌型医用超声耦合剂,它是由下述重量配比的原料药和辅料制备而成:
所述原料药为:铁线透骨草60-88份、荭草根59-86份、掌裂蟹甲草58-84份、红雪柳52-82份、偏翅唐松草根48-76份、柏子仁47-75份、矮卫矛42-70份、吹风藤40-66份、粳谷奴39-65份、细叶桉32-60份、燕子尾28-55份、隆萼当归根24-48份、石荠苎22-46份、秘鲁香胶15-25份;
所述辅料为:甘油10-25份、维生素E6-18份、丙二醇0.2-0.7份、邻苯基苯酚0.02-0.1份、苯乙醇0.03-0.09份。
进一步地,一种消毒杀菌型医用超声耦合剂,它是由下述重量配比的原料药和辅料制备而成:
所述原料药为:铁线透骨草74份、荭草根72.5份、掌裂蟹甲草71份、石荠苎69份、红雪柳67份、偏翅唐松草根62份、柏子仁61份、矮卫矛56份、吹风藤53份、粳谷奴52份、细叶桉46份、燕子尾41.5份、隆萼当归根36份、石荠苎34份、秘鲁香胶20份;
所述辅料为:甘油12.5份、维生素E8份、丙二醇0.45份、邻苯基苯酚0.06份、苯乙醇0.06份。
进一步地,将所述消毒杀菌型超声耦合剂以药学常规制备用工艺制成凝胶制剂。
进一步地,所述维生素E具有美颜功效,可保湿,润滑皮肤,使肌肤不受刺激。
进一步地,所述的一种消毒杀菌型超声耦合剂的制备方法为:
(1)取配方量的铁线透骨草、掌裂蟹甲草、红雪柳、吹风藤除尘去杂,并用紫外线灯进行杀菌后,放入烘箱中烘干,粉碎,研磨成140-160目细粉,备用;
(2)取配方量的荭草根、矮卫矛除杂洗净,先对荭草根去毒,将二者放入容器中捣碎再加入2-4倍纯净水,搅拌均匀,静置20-30分钟后过滤,得滤液备用;
(3)取配方量的偏翅唐松草根、粳谷奴、豆黄置入炒锅中文火炒至微焦,晾凉,研末,过110目筛,备用;
(4)取配方量的柏子仁、隆萼当归根除杂,在720W下微波提取其挥发油,备用;
(5)取配方量的细叶桉、燕子尾、石荠苎除杂,烘干后用粉碎机粉碎成粗粉,加4-6倍凉开水浸泡1-2小时,急火煮沸后改文火煎煮40-50分钟,提取;再加2-3倍水,急火煮沸,转文火煎煮20-30分钟,合并提取液,采用醇沉法去除杂质,将去除杂质的提取液经管式超速离心机分离,除去稀薄、微细悬浮颗粒,得到超滤液,减压浓缩得70℃时相对密度为1.26-1.35的浸膏,备用;
(6)将上述步骤(1)得到的细粉、步骤(2)得到的滤液、步骤(3)得到的细粉、步骤(4)得到的挥发油以及步骤(5)得到的浸膏与秘鲁香胶混合,按所述配比加入辅料甘油、维生素E、丙二醇、邻苯基苯酚、苯乙醇,搅拌均匀,调节PH至7,制成凝胶制剂。
上述所用的中药材的药理活性为:
铁线透骨草:【性味】味辛;咸;性温;小毒。【功能主治】祛风除湿通络止痛。主风湿性关节炎;四肢麻木;拘挛疼痛;牛皮癣;疥癞。
荭草根:【性味】辛;性凉;有毒。【功能主治】清热解毒;除湿通络;生肌敛疮。主痢疾;肠炎;水肿;脚气;风湿痹痛;跌打损伤;荨麻疹;疮痈肿痛或久溃不敛。
掌裂蟹甲草:【性味】味苦;辛;微甜。【功能主治】疏风解表;除湿通络;活血散瘀。主感冒关痛;发热咳嗽;腰腿疼痛;跌打损伤。
红雪柳:【性味】辛,凉。有小毒。【功能主治】消炎止痛,杀菌,解毒。主治疟疾。
偏翅唐松草根:【功能主治】杀菌消炎,发汗,消瘀,散毒,散气。治胃肠热症,赤痢。
柏子仁:【性味】甘,平。【功能主治】养心安神,润肠通便。治惊悸,失眠,遗精,盗汗,便秘。
矮卫矛:【性味】辛;苦;微温。【功能主治】祛风散寒;除湿通络。主风寒湿痹;关节肿痛;肢体麻木。
吹风藤:【性味】辛;微温。【功能主治】祛风散寒;除湿通络。主风寒湿痹;肾炎;劳伤。
粳谷奴:【性味】微咸,平。【功能主治】消炎,杀菌。用于走马喉痹。
细叶桉:【性味】辛、微苦,温。【功能主治】消炎杀菌,祛痰止咳,收敛杀虫。用于预防流行性感冒,流行性乙型脑炎。防治疟疾,肠炎,腹泻,痢疾,皮肤溃烂,痈疮红肿,丹毒,乳腺炎,外伤感染,皮癣,神经性皮炎。还可治钩端螺旋体病,气管炎,咳嗽,可杀蛆、熏蚊。
燕子尾:【性味】苦、微甘,温。【功能主治】补肺益气,消炎,杀菌。主治痢疾,肺结核,支气管炎。投入粪坑污水塘杀蛆、孑孓。
隆萼当归根:【性味】味辛;微甘;性温。【功能主治】活血调经;补血润燥。主月经不调;痛经;经闭;敌国虚萎黄;风湿骨痛;跌打损伤;肠燥便秘。
豆黄:【性味】甘,温,无毒。【功能主治】主湿痹、膝痛,五藏不足气,胃气结积;益气,润肌肤。末之收盛,炼猪膏为丸服之,能肥健人。
石荠苎:【性味】辛,温,无毒。【功能主治】清暑热,祛风湿,消肿,解毒。治暑热痧症,衄血,血痢,感冒咳嗽,慢性气管炎,痈疽疮肿,风疹,热痱,润肌肤。
秘鲁香胶:【性味】苦;辛;平。【功能主治】目咳祛痰;解毒杀虫。主慢性支气管炎;咳嗽痰多;痘疹;湿疹;皮肤伤损;疮疖疥癣。
本发明的有益效果是,本发明杀菌消毒型医用超声耦合剂组方严谨,配伍合理,精选多味具有杀菌消毒,润滑皮肤、活血化瘀功效的中草药,经临床验证没有任何毒副作用,避免了临床上超声检查的交叉感染,且成本低,易制备,对超声探头无腐蚀、气泡少,透声效果显著,超声成像清晰。
具体实施方式
实施例1:
一种消毒杀菌型医用超声耦合剂,它是由下述重量配比的原料药和辅料制备而成:所述原料药为:铁线透骨草60份、荭草根59份、掌裂蟹甲草58份、红雪柳52份、偏翅唐松草根48份、柏子仁47份、矮卫矛42份、吹风藤40份、粳谷奴39份、细叶桉32份、燕子尾28份、隆萼当归根24份、石荠苎22份、秘鲁香胶15份;所述辅料为:甘油10份、维生素E6份、丙二醇0.2份、邻苯基苯酚0.02份、苯乙醇0.03份。
所述的一种消毒杀菌型医用超声耦合剂的制备方法为:
(1)取配方量的铁线透骨草、掌裂蟹甲草、红雪柳、吹风藤除尘去杂,并用紫外线灯进行杀菌后,放入烘箱中烘干,粉碎,研磨成140目细粉,备用;
(2)取配方量的荭草根、矮卫矛除杂洗净,先对荭草根去毒,将二者放入容器中捣碎再加入2倍纯净水,搅拌均匀,静置20分钟后过滤,得滤液备用;
(3)取配方量的偏翅唐松草根、粳谷奴、豆黄置入炒锅中文火炒至微焦,晾凉,研末,过110目筛,备用;
(4)取配方量的柏子仁、隆萼当归根除杂,在720W下微波提取其挥发油,备用;
(5)取配方量的细叶桉、燕子尾、石荠苎除杂,烘干后用粉碎机粉碎成粗粉,加4倍凉开水浸泡1小时,急火煮沸后改文火煎煮40分钟,提取;再加2倍水,急火煮沸,转文火煎煮20分钟,合并提取液,采用醇沉法去除杂质,将去除杂质的提取液经管式超速离心机分离,除去稀薄、微细悬浮颗粒,得到超滤液,减压浓缩得70℃时相对密度为1.26的浸膏,备用;
(6)将上述步骤(1)得到的细粉、步骤(2)得到的滤液、步骤(3)得到的细粉、步骤(4)得到的挥发油以及步骤(5)得到的浸膏与秘鲁香胶混合,按所述配比加入辅料甘油、维生素E、丙二醇、邻苯基苯酚、苯乙醇,搅拌均匀,调节PH至7,制成凝胶制剂。
实施例2:
一种消毒杀菌型医用超声耦合剂,它是由下述重量配比的原料药和辅料制备而成:所述原料药为:铁线透骨草74份、荭草根72.5份、掌裂蟹甲草71份、石荠苎69份、红雪柳67份、偏翅唐松草根62份、柏子仁61份、矮卫矛56份、吹风藤53份、粳谷奴52份、细叶桉46份、燕子尾41.5份、隆萼当归根36份、石荠苎34份、秘鲁香胶20份;所述辅料为:甘油12.5份、维生素E8份、丙二醇0.45份、邻苯基苯酚0.06份、苯乙醇0.06份。
所述的一种消毒杀菌型医用超声耦合剂的制备方法为:
(1)取配方量的铁线透骨草、掌裂蟹甲草、红雪柳、吹风藤除尘去杂,并用紫外线灯进行杀菌后,放入烘箱中烘干,粉碎,研磨成150目细粉,备用;
(2)取配方量的荭草根、矮卫矛除杂洗净,先对荭草根去毒,将二者放入容器中捣碎再加入3倍纯净水,搅拌均匀,静置25分钟后过滤,得滤液备用;
(3)取配方量的偏翅唐松草根、粳谷奴、豆黄置入炒锅中文火炒至微焦,晾凉,研末,过110目筛,备用;
(4)取配方量的柏子仁、隆萼当归根除杂,在720W下微波提取其挥发油,备用;
(5)取配方量的细叶桉、燕子尾、石荠苎除杂,烘干后用粉碎机粉碎成粗粉,加5倍凉开水浸泡1.5小时,急火煮沸后改文火煎煮45分钟,提取;再加2.5倍水,急火煮沸,转文火煎煮25分钟,合并提取液,采用醇沉法去除杂质,将去除杂质的提取液经管式超速离心机分离,除去稀薄、微细悬浮颗粒,得到超滤液,减压浓缩得70℃时相对密度为1.31的浸膏,备用;
(6)将上述步骤(1)得到的细粉、步骤(2)得到的滤液、步骤(3)得到的细粉、步骤(4)得到的挥发油以及步骤(5)得到的浸膏与秘鲁香胶混合,按所述配比加入辅料甘油、维生素E、丙二醇、邻苯基苯酚、苯乙醇,搅拌均匀,调节PH至7,制成凝胶制剂。
实施例3:
一种消毒杀菌型医用超声耦合剂,它是由下述重量配比的原料药和辅料制备而成:所述原料药为:铁线透骨草88份、荭草根86份、掌裂蟹甲草84份、红雪柳82份、偏翅唐松草根76份、柏子仁75份、矮卫矛70份、吹风藤66份、粳谷奴65份、细叶桉60份、燕子尾55份、隆萼当归根48份、石荠苎46份、秘鲁香胶25份;所述辅料为:甘油25份、维生素E18份、丙二醇0.7份、邻苯基苯酚0.1份、苯乙醇0.09份。
所述的一种消毒杀菌型医用超声耦合剂的制备方法为:
(1)取配方量的铁线透骨草、掌裂蟹甲草、红雪柳、吹风藤除尘去杂,并用紫外线灯进行杀菌后,放入烘箱中烘干,粉碎,研磨成160目细粉,备用;
(2)取配方量的荭草根、矮卫矛除杂洗净,先对荭草根去毒,将二者放入容器中捣碎再加入4倍纯净水,搅拌均匀,静置30分钟后过滤,得滤液备用;
(3)取配方量的偏翅唐松草根、粳谷奴、豆黄置入炒锅中文火炒至微焦,晾凉,研末,过110目筛,备用;
(4)取配方量的柏子仁、隆萼当归根除杂,在720W下微波提取其挥发油,备用;
(5)取配方量的细叶桉、燕子尾、石荠苎除杂,烘干后用粉碎机粉成粗粉,加6倍凉开水浸泡1-2小时,急火煮沸后改文火煎煮50分钟,提取;再加3倍水,急火煮沸,转文火煎煮30分钟,合并提取液,采用醇沉法去除杂质,将去除杂质的提取液经管式超速离心机分离,除去稀薄、微细悬浮颗粒,得到超滤液,减压浓缩得70℃时相对密度为1.35的浸膏,备用;
(6)将上述步骤(1)得到的细粉、步骤(2)得到的滤液、步骤(3)得到的细粉、步骤(4)得到的挥发油以及步骤(5)得到的浸膏与秘鲁香胶混合,按所述配比加入辅料甘油、维生素E、丙二醇、邻苯基苯酚、苯乙醇,搅拌均匀,调节PH至7,制成凝胶制剂。
临床应用效果:
1.临床资料:
选择超声诊疗患者300例,将患者随机分为两组,实验组150例,其中男85例,女65例,年龄在10-76岁之间,平均年龄40岁;对照组150例,其中男70例,女80例,年龄在10-72岁之间,平均年龄39岁。
2.超声诊疗:
实验组采用本发明超声耦合剂,对照组采用MIBO医用超声耦合剂,将超声耦合剂挤出,涂抹于超声检查部位,滑动超声探头对身体进行检查。
3.使用效果:
实验组:图像清晰率达97%,无皮肤过敏和交叉感染患者。
对照组:图像清晰率90%,皮肤过敏患者5例,交叉感染患者2例。
4.结论:
通过以上对比实验可见,本发明杀菌消毒型超声耦合剂具有润滑皮肤、杀菌消炎功效,且透声效果显著,超声成像清晰,对超声探头无腐蚀,成本低,易制备。
最后应说明的是:以上实施例仅用以说明本发明的技术方案,而非对其限制;尽管参照前述实施例对本发明进行了详细的说明,本领域的普通技术人员应当理解:其依然可以对前述实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换;而这些修改或者替换,并不使相应技术方案的本质脱离本发明实施例技术方案的精神和范围。
Claims (7)
1.一种消毒杀菌型医用超声耦合剂,其特征在于:它是由下述重量配比的原料药和辅料制备而成:
所述原料药为:铁线透骨草60-88份、荭草根59-86份、掌裂蟹甲草58-84份、红雪柳52-82份、偏翅唐松草根48-76份、柏子仁47-75份、矮卫矛42-70份、吹风藤40-66份、粳谷奴39-65份、细叶桉32-60份、燕子尾28-55份、隆萼当归根24-48份、石荠苎22-46份、秘鲁香胶15-25份;
所述辅料为:甘油10-25份、维生素E6-18份、丙二醇0.2-0.7份、邻苯基苯酚0.02-0.1份、苯乙醇0.03-0.09份。
2.根据权利要求1所述的一种消毒杀菌型医用超声耦合剂,其特征在于:它是由下述重量配比的原料药和辅料制备而成:
所述原料药为:铁线透骨草74份、荭草根72.5份、掌裂蟹甲草71份、红雪柳67份、偏翅唐松草根62份、柏子仁61份、矮卫矛56份、吹风藤53份、粳谷奴52份、细叶桉46份、燕子尾41.5份、隆萼当归根36份、石荠苎34份、秘鲁香胶20份;
所述辅料为:甘油12.5份、维生素E8份、丙二醇0.45份、邻苯基苯酚0.06份、苯乙醇0.06份。
3.根据权利要求1所述的一种消毒杀菌型医用超声耦合剂,其特征在于:所述润湿剂为甘油和丙二醇。
4.根据权利要求1所述的一种消毒杀菌型医用超声耦合剂,其特征在于:所述抗菌剂为邻苯基苯酚。
5.根据权利要求1所述的一种消毒杀菌型医用超声耦合剂,其特征在于:所述防腐剂为苯乙醇。
6.根据权利要求1~5任意一项所述的一种消毒杀菌型医用超声耦合剂,其特征在于:是以药学常规制备用工艺制成凝胶制剂。
7.一种如权利要求1至6任意一项所述的一种消毒杀菌型医用耦合剂的制备方法,其特征在于包括以下步骤:
(1)取配方量的铁线透骨草、掌裂蟹甲草、红雪柳、吹风藤除尘去杂,并用紫外线灯进行杀菌后,烘干,粉碎,研磨成140-160目细粉,备用;
(2)取配方量的荭草根、矮卫矛除杂洗净,先对荭草根去毒,将二者捣碎加入2-4倍纯净水,搅拌均匀,静置20-30分钟后过滤,得滤液备用;
(3)取配方量的偏翅唐松草根、粳谷奴文火炒至微焦,晾凉,研末,过110目筛,备用;
(4)取配方量的柏子仁、隆萼当归根在720W下微波提取其挥发油,备用;
(5)取配方量的细叶桉、燕子尾、石荠苎除杂,烘干后用粉碎机粉碎成粗粉,加4-6倍凉开水浸泡1-2小时,急火煮沸后改文火煎煮40-50分钟,提取;再加2-3倍水,急火煮沸,转文火煎煮20-30分钟,合并提取液,采用醇沉法去除杂质,将去除杂质的提取液经管式超速离心机分离,除去稀薄、微细悬浮颗粒,得到超滤液,减压浓缩得70℃时相对密度为1.26-1.35的浸膏,备用;
(6)将上述步骤(1)得到的细粉、步骤(2)得到的滤液、步骤(3)得到的细粉、步骤(4)得到的挥发油以及步骤(5)得到的浸膏与秘鲁香胶混合,按所述配比加入辅料甘油、维生素E、丙二醇、邻苯基苯酚、苯乙醇,搅拌均匀,调节PH至7,制成凝胶制剂。
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