CN105435223A - 使用gm-csf拮抗剂治疗慢性炎症疾病的方法 - Google Patents

使用gm-csf拮抗剂治疗慢性炎症疾病的方法 Download PDF

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Publication number
CN105435223A
CN105435223A CN201510674256.5A CN201510674256A CN105435223A CN 105435223 A CN105435223 A CN 105435223A CN 201510674256 A CN201510674256 A CN 201510674256A CN 105435223 A CN105435223 A CN 105435223A
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antibody
csf
purposes
patient
methotrexate
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Chinese (zh)
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克里斯托弗·R·贝炳东
杰弗里·T·亚兰东
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Humanigen Inc
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Kalobios Pharmaceuticals Inc
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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  • Urology & Nephrology (AREA)
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CN201510674256.5A 2006-11-21 2007-11-21 使用gm-csf拮抗剂治疗慢性炎症疾病的方法 Pending CN105435223A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86078006P 2006-11-21 2006-11-21
US60/860,780 2006-11-21
US90274207P 2007-02-21 2007-02-21
US60/902,742 2007-02-21
CNA2007800495322A CN101605547A (zh) 2006-11-21 2007-11-21 使用gm-csf拮抗剂治疗慢性炎症疾病的方法

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CN105435223A true CN105435223A (zh) 2016-03-30

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CNA2007800495322A Pending CN101605547A (zh) 2006-11-21 2007-11-21 使用gm-csf拮抗剂治疗慢性炎症疾病的方法

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US (2) US20080206241A1 (https=)
EP (2) EP2101780B1 (https=)
JP (1) JP5410293B2 (https=)
KR (1) KR101517251B1 (https=)
CN (2) CN105435223A (https=)
AU (1) AU2007323541B2 (https=)
BR (1) BRPI0719109A2 (https=)
CA (1) CA2670288C (https=)
EA (1) EA200900709A1 (https=)
ES (1) ES2432173T3 (https=)
IL (1) IL198829A0 (https=)
MX (1) MX2009005398A (https=)
NZ (1) NZ598345A (https=)
SG (1) SG176503A1 (https=)
WO (1) WO2008064321A2 (https=)

Cited By (1)

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CN109219616A (zh) * 2016-09-19 2019-01-15 天境生物 Gm-csf抗体及其用途

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WO2009023184A2 (en) * 2007-08-10 2009-02-19 Protelix, Inc. Universal fibronectin type iii binding-domain libraries
US8470966B2 (en) 2007-08-10 2013-06-25 Protelica, Inc. Universal fibronectin type III binding-domain libraries
TW200918553A (en) * 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
CN104072613A (zh) 2007-11-13 2014-10-01 Evec股份有限公司 与hGM-CSF结合的单克隆抗体及包含它的药物组合物
US20090181020A1 (en) * 2008-01-15 2009-07-16 Kalobios Pharmaceuticals, Inc. Methods of Treating Bone-Loss Disorders Using a GM-CSF Antagonist
EP2282757B1 (en) * 2008-04-07 2013-05-22 Kalobios Pharmaceuticals, Inc. Neutralization of gm-csf for the treatment of heart failure
WO2009134805A2 (en) * 2008-04-28 2009-11-05 Kalobios Pharmaceuticals, Inc. Antibodies to granulocyte-macrophage colony-stimulating factor
AU2015224416B2 (en) * 2008-12-22 2017-04-20 The University Of Melbourne Osteoarthritis treatment
CN102271705A (zh) * 2008-12-22 2011-12-07 墨尔本大学 骨关节炎治疗
CA2747206C (en) 2008-12-22 2018-04-24 The University Of Melbourne Pain treatment
WO2010093814A1 (en) * 2009-02-11 2010-08-19 Kalobios Pharmaceuticals, Inc. Methods of treating dementia using a gm-csf antagonist
US8609101B2 (en) * 2009-04-23 2013-12-17 Theraclone Sciences, Inc. Granulocyte-macrophage colony-stimulating factor (GM-CSF) neutralizing antibodies
US20120116059A1 (en) * 2009-05-05 2012-05-10 Morphosys Ag Treatment For M Treatment For Multiple Sclerosis
CN103827143A (zh) * 2011-07-06 2014-05-28 莫弗系统股份公司 抗cd20抗体和抗gm-csf抗体的治疗性组合产品及其用途
MA37946B1 (fr) * 2012-09-20 2018-09-28 Morphosys Ag Utilisation d’un anticorps anti-gm-csf pour le traitement de la polyarthrite rhumatoïde
KR20210021153A (ko) * 2012-09-20 2021-02-24 모르포시스 아게 류마티스 관절염에 대한 치료
AR093297A1 (es) * 2012-10-31 2015-05-27 Amgen Res Munich Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf
US10745475B2 (en) * 2013-08-30 2020-08-18 Takeda Gmbh Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics
JP6360696B2 (ja) * 2014-03-18 2018-07-18 日本光電工業株式会社 血液検査装置および血液検査方法
CN106456761A (zh) * 2014-05-19 2017-02-22 免疫医疗有限公司 对类风湿关节炎的治疗
WO2018031968A1 (en) * 2016-08-12 2018-02-15 L.E.A.F. Holdings Group Llc Alpha and gamma-d polyglutamated antifolates and uses thereof
US11130805B2 (en) 2017-10-02 2021-09-28 Humanigen, Inc. Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist
US10899831B2 (en) 2017-10-02 2021-01-26 Humanigen, Inc. Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity
US10927168B2 (en) 2017-10-02 2021-02-23 Humanicen, Inc. Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab
AU2018345751A1 (en) * 2017-10-02 2020-05-07 Humanigen, Inc. Methods of treating immunotherapy-related toxicity using a GM-CSF antagonist
WO2020092850A1 (en) * 2018-10-31 2020-05-07 Humanigen, Inc. Materials and methods for treating cancer
MX2022011111A (es) * 2020-03-08 2023-03-02 Humanigen Inc Métodos para tratar infección de coronavirus y lesión pulmonar inducida por inflamación resultante.
AU2021392308A1 (en) * 2020-12-04 2023-06-22 CSL Innovation Pty Ltd Methods for treating inflammatory skin conditions
WO2022192093A1 (en) * 2021-03-08 2022-09-15 Humanigen, Inc. Methods for treating coronavirus infection and resulting inflammation-induced lung injury
CN116887856A (zh) * 2022-01-20 2023-10-13 舒泰神（北京）生物制药股份有限公司 一种特异性地识别粒细胞-巨噬细胞集落刺激因子受体的抗体制剂及其应用

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