CN105412889A - 治疗腰椎间盘突出的中药蜜丸及其制备方法 - Google Patents
治疗腰椎间盘突出的中药蜜丸及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种治疗腰椎间盘突出的中药蜜丸及其制备方法,属中医中药技术领域。所述中药蜜丸由以下中药原料制成:杜仲、寄生、鸡血藤、当归、独活、骨碎补、白芍、赤芍、伸筋草、续断、黄芪、肉桂、附子、细辛、茯苓、薏米、麸炒白术、牛膝、南星、白花蛇、蜈蚣、全蝎、丹参、干姜、螃蟹、香附份、陈皮、板蓝根、石决明、山萸肉、黄柏、蜣螂虫和蜂蜜。本发明所述中药蜜丸组方严谨、科学高效,见效快、治愈率高,安全、无副作用;所述制备方法工艺简单、易于实现。
Description
技术领域
本发明涉及一种治疗腰椎间盘突出的中药蜜丸及其制备方法,属中医中药技术领域。
背景技术
腰椎间盘突出症是较为常见的疾患之一,主要是因为腰椎间盘各部分(髓核、纤维环及软骨板),尤其是髓核,有不同程度的退行性改变后,在外力因素的作用下,椎间盘的纤维环破裂,髓核组织从破裂之处突出(或脱出)于后方或椎管内,导致相邻脊神经根遭受刺激或压迫,从而产生腰部疼痛,一侧下肢或双下肢麻木、疼痛等一系列临床症状。
其病因主要分以下六种:
(1)腰椎间盘的退行性改变
髓核的退变主要表现为含水量的降低,并可因失水引起椎节失稳、松动等小范围的病理改变;纤维环的退变主要表现为坚韧程度的降低。
(2)损伤
长期反复的外力造成轻微损害,加重了退变的程度。
(3)椎间盘自身解剖因素的弱点
椎间盘在成年之后逐渐缺乏血液循环,修复能力差。在上述因素作用的基础上,某种可导致椎间盘所承受压力突然升高的诱发因素,即可能使弹性较差的髓核穿过已变得不太坚韧的纤维环,造成髓核突出。
(4)遗传因素
腰椎间盘突出症有家族性发病的报道。
(5)腰骶先天异常
包括腰椎骶化、骶椎腰化、半椎体畸形、小关节畸形和关节突不对称等。上述因素可使下腰椎承受的应力发生改变,从而构成椎间盘内压升高、易发生退变和损伤。
(6)诱发因素
在椎间盘退行性变的基础上,某种可诱发椎间隙压力突然升高的因素可致髓核突出。常见的诱发因素有增加腹压、腰姿不正、突然负重、妊娠、受寒和受潮等。
目前,针对腰椎间盘突出症主要有三种方法:非手术疗法、经皮髓核切吸术/髓核激光气化术和手术治疗。非手术治疗主要适用于年轻、初次发作、病程较短者以及症状较轻,休息后症状可自行缓解者。经皮髓核切吸术/髓核激光气化术适合于膨出或轻度突出的病人,不适于合并侧隐窝狭窄或者已有明显突出的患者及髓核已脱入椎管内者。手术治疗要使用抗生素类药物防止感染,副作用大,疗效慢,治疗效果不理想,给病人及家属带来诸多不便。
发明内容
本发明的目的是提供一种治疗腰椎间盘突出的中药蜜丸,具有见效快、疗程短、疗效好、安全方便、无毒副作用的特点;本发明同时提供其制备方法。
本发明所述的治疗腰椎间盘突出的中药蜜丸,由以下重量份数的中药原料制成:杜仲50~100份、寄生50~100份、鸡血藤40~80份、当归60~100份、独活50~100份、骨碎补50~100份、白芍40~80份、赤芍40~80份、伸筋草40~80份、续断50~100份、黄芪50~150份、肉桂5~25份、附子40~80份、细辛10~50份、茯苓10~50份、薏米40~80份、麸炒白术60~100份、牛膝50~90份、南星20~80份、白花蛇10~50份、蜈蚣10~50份、全蝎10~50份、丹参25~70份、干姜10~50份、螃蟹80~160份、香附40~80份、陈皮10~50份、板蓝根40~80份、石决明80~160份、山萸肉20~100份、黄柏10~50份、蜣螂虫60~100份和蜂蜜2500~3000份。
优选为由以下重量份数的中药原料制成:杜仲60~90份、寄生60~90份、鸡血藤50~70份、当归70~90份、独活60~90份、骨碎补60~90份、白芍50~70份、赤芍50~70份、伸筋草50~70份、续断60~90份、黄芪70~130份、肉桂10~20份、附子50~70份、细辛20~40份、茯苓20~40份、薏米50~70份、麸炒白术70~90份、牛膝60~80份、南星40~60份、白花蛇20~40份、蜈蚣20~40份、全蝎20~40份、丹参40~55份、干姜20~40份、螃蟹100~140份、香附50~70份、陈皮20~40份、板蓝根50~70份、石决明100~140份、山萸肉50~70份、黄柏20~40份、蜣螂虫70~90份和蜂蜜2600~2900份。
更优选为由以下重量份数的中药原料制成:杜仲75份、寄生75份、鸡血藤60份、当归80份、独活75份、骨碎补75份、白芍60份、赤芍60份、伸筋草60份、续断75份、黄芪100份、肉桂15份、附子60份、细辛30份、茯苓30份、薏米60份、麸炒白术80份、牛膝70份、南星50份、白花蛇30份、蜈蚣30份、全蝎30份、丹参45份、干姜30份、螃蟹120份、香附60份、陈皮30份、板蓝根60份、石决明120份、山萸肉60份、黄柏30份、蜣螂虫80份和蜂蜜2750份。
所述的治疗腰椎间盘突出的中药蜜丸的制备方法,包括如下步骤:
(1)将除蜂蜜外的其它原料混合均匀,粉碎并过100~200目筛,得中药细粉;
(2)炼制蜂蜜,然后加入步骤(1)过筛得到的中药细粉混匀,降温至60℃以下时,制成丸剂,包装,每丸重6~9g。
其中,炼制蜂蜜为:将蜂蜜加热至119℃~122℃,此时,蜂蜜颜色呈棕红色,滴入冷水呈珠状。
用法及用量:口服,每次1丸,每日2~3次,30天为一疗程。
本发明中的药物机理如下:
杜仲:补肝肾、强筋骨。
寄生:祛风湿、补肝肾、强筋骨。
鸡血藤:补血活血、通经、舒筋活络。本品能养血、活血而舒筋活络,是治疗风湿弊病、关节痛、肢体麻木的常用品。
当归:补血活血、调经止痛、润肠。
独活:祛风湿止痹痛、解表。
骨碎补:活血续伤、补肾强骨,本品能行血脉、续筋骨、疗伤止痛。
白芍:养血调经、平肝止痛、敛阴止汗,有很好的调肝气、缓急止痛的功效。
赤芍:清热凉血、散瘀止痛。本品苦寒,主入肝经、善走血分,能清肝火,除血分郁热而有凉血、止血、散瘀的功效。
伸筋草:舒筋活络。
续断:补肝,强筋骨,定经络,止经中酸痛。
黄芪:补气升阳、益卫固表、利水消肿、托疮生肌。
肉桂:补土助阳、散寒止痛、温经通脉。
附子:主治风寒咳逆邪气,温中,除寒湿,治手足折伤,拘挛、膝痛不能行走,破肿块坚硬、血瘕、金属损伤疮伤。
细辛:祛风散寒、通窍、止痛、温肺化饮。
茯苓:利湿健脾、安神。
薏米:清热利湿,除风湿,利小便,益肺排脓,健脾胃,强筋骨。
麸炒白术:用于脾胃不和,运化失常,食少胀满倦怠乏力,表虚自汗。
牛膝:活血通经、补肝肾、强筋骨、利水消肿。
南星:散风、祛痰、镇惊、止痛,可治中风麻痹,手足痉挛,头痛眩晕,惊风痰盛等症。
白花蛇:祛风通络、定惊止痉。本品祛风力猛,兼善通经络。
蜈蚣:息风镇痉,功毒散结,通络止痛。
全蝎:息风止痉、攻毒散结、通络止痛。
丹参:活血调经、凉血消痈、安神。
干姜:温中散寒,回阳通脉,温肺化饮。
螃蟹:具有舒筋益气、理胃消食、通经络、散诸热、清热、滋阴之功,可治疗跌打损伤、筋伤骨折、过敏性皮炎。
香附:疏肝理气调经止痛。本品辛能通行、苦能疏泄,微甘缓急,为疏肝解郁、行气止痛之要药。
陈皮:理气健脾、燥湿化痰,本品即能燥湿化痰又能温化寒痰,且辛行苦泄,能宣肺止咳,为治咳之要药。
板蓝根:具有清热解毒、凉血利咽之功效,常用于治疗温热病等。
石决明:有清热、镇静、降血压、拟交感神经的作用。
山萸肉:补肝肾,涩精气,固虚脱。
黄柏:有清热燥湿,泻火除蒸,解毒疗疮的功效。
蜣螂虫:拔毒生肌,散肿止血。
蜂蜜:补中缓急、润燥、解毒,常用于肺虚燥咳。
以上诸药的主治及功效均参考:中医药院校本科教材《中药学》。
以下为临床试验总结:临床试验治疗腰椎间盘突出患者60例。患者腰椎间盘突出病史最短者6个月,最长者3年。
治疗方案:服用实施例丸剂,一次1丸,每日2~3次,30天为一疗程。
治疗标准:
痊愈:腰、臀部及下肢放射性疼痛伴有麻木感等症状全部消失,CT片显示髓核回缩,纤维盘愈合,全身无阳性体征可查。
有效:症状减轻,CT片显示髓核回缩,纤维盘愈合不完全,阳性体征存在。
无效:治疗后症状体征无明显改善,CT片显示同治疗前。
治疗结果:腰椎间盘突出患者经过三个疗程治疗后痊愈36例,占60%;有效18例,占30%;无效6例,占10%。总有效率为90%。
经临床观察,病人无任何不良反应,三大常规化验及肝肾功能检测未发现异常现象。
以下列举几个典型病例:
病例1:患者王某某,女,48岁,腰痛伴腿痛、腿麻不能直立,活动欠佳半年余,经诊断为腰椎间L4-5椎间盘突出0.4cm,服用本发明药物三个疗程后症状完全消失,CT片检查正常,随访一年无复发。
病例2:患者徐某某,男,65岁,患椎间盘突出症2年余;长期腰腿疼痛、活动受限;近半年来,感觉右下肢麻木加重,多方治疗效果不明显,服用本发明药物三个疗程后症状完全消失,活动自如,随访一年未复发。
病例3:患者赵某某,男,35岁,因长期办公室工作导致椎间盘突出症,患病1年余,中西药治疗收效甚微;右下肢疼痛伴麻木、活动受限;CT检查显示4、5腰椎间盘突出0.6cm,服用本发明药物三个疗程后症状完全消失,CT检查恢复正常,随访一年未复发。
本发明药物临床使用表明有如下优点:
(1)本发明所选用的中草药均符合《中华人民共和国药典》规定,根据配伍本发明具有强健筋骨、祛瘀通络之功效。
(2)本发明是在传统的中医辨证施治的基础上结合临床试验研制而成的,补肝肾,搜风去湿,舒筋活络,对腰椎间盘突出症具有显著疗效,总有效率达90%。
(3)腰椎间盘突出症,中医归于痹症,腰腿疼范畴。痹症病程长久,湿淤日阻,热毒必生,与湿淤搏结,痰浊内生,加重淤阻。板蓝根清热解毒,消炎清热。螃蟹通经络,散诸热,清热滋阴,舒筋益气,补肾填髓,养筋接骨。两药合用,相得益彰。蜣螂虫善走窜脉络,散结通阳,拔毒生肌,散肿止血,推陈出新,止疼。三药合用,伍用他药,更增祛瘀除湿,通络止疼,促进椎间盘突出回纳之功。
(4)本发明组方严谨、科学高效,见效快、治愈率高,安全、无副作用。
(5)本发明所述制备方法,工艺简单、易于实现
具体实施方式
下面结合实施例对本发明做进一步说明。
实施例1
本实施例所述的治疗腰椎间盘突出的中药蜜丸,由以下重量份数的中药原料制成:
杜仲75份、寄生75份、鸡血藤60份、当归80份、独活75份、骨碎补75份、白芍60份、赤芍60份、伸筋草60份、续断75份、黄芪100份、肉桂15份、附子60份、细辛30份、茯苓30份、薏米60份、麸炒白术80份、牛膝70份、南星50份、白花蛇30份、蜈蚣30份、全蝎30份、丹参45份、干姜30份、螃蟹120份、香附60份、陈皮30份、板蓝根60份、石决明120份、山萸肉60份、黄柏30份、蜣螂虫80份和蜂蜜2750份。
其制备方法如下:
(1)将除蜂蜜外的其它原料混合均匀,粉碎并过100目筛,得中药细粉;
(2)炼制蜂蜜,然后加入步骤(1)过筛得到的中药细粉混匀,降温至60℃时,制成丸剂,包装,每丸重7.5g。
实施例2
本实施例所述的治疗腰椎间盘突出的中药蜜丸,由以下重量份数的中药原料制成:
杜仲50份、寄生50份、鸡血藤40份、当归60份、独活50份、骨碎补50份、白芍40份、赤芍40份、伸筋草40份、续断50份、黄芪50份、肉桂5份、附子40份、细辛10份、茯苓10份、薏米40份、麸炒白术60份、牛膝50份、南星20份、白花蛇10份、蜈蚣10份、全蝎10份、丹参25份、干姜10份、螃蟹80份、香附40份、陈皮10份、板蓝根40份、石决明80份、山萸肉20份、黄柏10份、蜣螂虫60份和蜂蜜2500份。
其制备方法如下:
(1)将除蜂蜜外的其它原料混合均匀,粉碎并过150目筛,得中药细粉;
(2)炼制蜂蜜,然后加入步骤(1)过筛得到的中药细粉混匀,降温至55℃时,制成丸剂,包装,每丸重9g。
实施例3
本实施例所述的治疗腰椎间盘突出的中药蜜丸,由以下重量份数的中药原料制成:
杜仲100份、寄生100份、鸡血藤80份、当归100份、独活100份、骨碎补100份、白芍80份、赤芍80份、伸筋草80份、续断100份、黄芪150份、肉桂25份、附子80份、细辛50份、茯苓50份、薏米80份、麸炒白术100份、牛膝90份、南星80份、白花蛇50份、蜈蚣50份、全蝎50份、丹参70份、干姜50份、螃蟹160份、香附80份、陈皮50份、板蓝根80份、石决明160份、山萸肉100份、黄柏50份、蜣螂虫100份和蜂蜜3000份。
其制备方法如下:
(1)将除蜂蜜外的其它原料混合均匀,粉碎并过200目筛,得中药细粉;
(2)炼制蜂蜜,然后加入步骤(1)过筛得到的中药细粉混匀,降温至50℃时,制成丸剂,包装,每丸重6g。
Claims (4)
1.一种治疗腰椎间盘突出的中药蜜丸,其特征在于:由以下重量份数的中药原料制成:杜仲50~100份、寄生50~100份、鸡血藤40~80份、当归60~100份、独活50~100份、骨碎补50~100份、白芍40~80份、赤芍40~80份、伸筋草40~80份、续断50~100份、黄芪50~150份、肉桂5~25份、附子40~80份、细辛10~50份、茯苓10~50份、薏米40~80份、麸炒白术60~100份、牛膝50~90份、南星20~80份、白花蛇10~50份、蜈蚣10~50份、全蝎10~50份、丹参25~70份、干姜10~50份、螃蟹80~160份、香附40~80份、陈皮10~50份、板蓝根40~80份、石决明80~160份、山萸肉20~100份、黄柏10~50份、蜣螂虫60~100份和蜂蜜2500~3000份。
2.根据权利要求1所述的治疗腰椎间盘突出的中药蜜丸,其特征在于:由以下重量份数的中药原料制成:杜仲60~90份、寄生60~90份、鸡血藤50~70份、当归70~90份、独活60~90份、骨碎补60~90份、白芍50~70份、赤芍50~70份、伸筋草50~70份、续断60~90份、黄芪70~130份、肉桂10~20份、附子50~70份、细辛20~40份、茯苓20~40份、薏米50~70份、麸炒白术70~90份、牛膝60~80份、南星40~60份、白花蛇20~40份、蜈蚣20~40份、全蝎20~40份、丹参40~55份、干姜20~40份、螃蟹100~140份、香附50~70份、陈皮20~40份、板蓝根50~70份、石决明100~140份、山萸肉50~70份、黄柏20~40份、蜣螂虫70~90份和蜂蜜2600~2900份。
3.根据权利要求2所述的治疗腰椎间盘突出的中药蜜丸,其特征在于:由以下重量份数的中药原料制成:杜仲75份、寄生75份、鸡血藤60份、当归80份、独活75份、骨碎补75份、白芍60份、赤芍60份、伸筋草60份、续断75份、黄芪100份、肉桂15份、附子60份、细辛30份、茯苓30份、薏米60份、麸炒白术80份、牛膝70份、南星50份、白花蛇30份、蜈蚣30份、全蝎30份、丹参45份、干姜30份、螃蟹120份、香附60份、陈皮30份、板蓝根60份、石决明120份、山萸肉60份、黄柏30份、蜣螂虫80份和蜂蜜2750份。
4.一种权利要求1-3任一所述的治疗腰椎间盘突出的中药蜜丸的制备方法,其特征在于:包括如下步骤:
(1)将除蜂蜜外的其它原料混合均匀,粉碎并过100~200目筛,得中药细粉;
(2)炼制蜂蜜,然后加入步骤(1)过筛得到的中药细粉混匀,降温至60℃以下时,制成丸剂,包装,每丸重6~9g。
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