CN105395755A - 治疗变应性鼻炎的内服药 - Google Patents

治疗变应性鼻炎的内服药 Download PDF

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CN105395755A
CN105395755A CN201510851391.2A CN201510851391A CN105395755A CN 105395755 A CN105395755 A CN 105395755A CN 201510851391 A CN201510851391 A CN 201510851391A CN 105395755 A CN105395755 A CN 105395755A
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马瑞
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Abstract

本发明提供一种治疗变应性鼻炎的内服药。该内服药由下述原料制得：蒺藜、益母草、海螵蛸、仙人掌、大苞芹、当归、桂圆肉、白芍、乌梅肉、大腹皮、泽泻、五味子、巴戟天、荷叶、葛根叶、银柴胡、香加皮、急性子、蛇床子。其制备方法为：将原料粉碎，加水和酵母，于35～38℃的条件下发酵5～10天，过滤，滤渣加水煎煮，过滤，合并两次滤液，加热后加入蜂蜜和酪蛋白酸钠，喷雾干燥即得。本发明是一种毒副作用小、见效快、疗效好的治疗变应性鼻炎的内服药。

Description

治疗变应性鼻炎的内服药
技术领域
本发明涉及一种治疗变应性鼻炎的内服药，属于中药技术领域。
背景技术
变应性鼻炎即过敏性鼻炎，是指特应性个体接触变应原后，主要由IgE介导的介质(主要是组胺)释放，并有多种免疫活性细胞和细胞因子等参与的鼻黏膜非感染性炎性疾病。其发生的必要条件有3个：特异性抗原即引起机体免疫反应的物质；特应性个体即所谓个体差异、过敏体质；特异性抗原与特应型个体二者相遇。变应性鼻炎是一个全球性健康问题，可导致许多疾病和劳动力丧失。目前，市场上出现了各种治疗变应性鼻炎的药。例如，CN103446573A公开了一种治疗过敏性鼻炎的药物，治疗时无毒副作用，治愈率高，但其使用了人参等名贵药材，药品价格昂贵。
发明内容
本发明要解决的技术问题是：提供一种治疗变应性鼻炎的内服药，具有价格低、毒副作用小、见效快和疗效好等优点。
为解决上述技术问题，本发明采用以下技术方案：
治疗变应性鼻炎的内服药，由下述重量份的原料制得：
蒺藜20～30份、益母草20～30份、海螵蛸20～30份、仙人掌20～30份、大苞芹20～30份、当归20～30份、桂圆肉10～20份、白芍10～20份、乌梅肉10～20份、大腹皮10～20份、泽泻10～20份、五味子1～10份、巴戟天1～10份、荷叶1～10份、葛根叶1～10份、银柴胡1～10份、香加皮0.1～1份、急性子0.1～1份、蛇床子0.1～1份。
作为优选的，这里给出一个具体的配方，所述原料的重量份为：
蒺藜30份、益母草20份、海螵蛸25份、仙人掌30份、大苞芹20份、当归25份、桂圆肉20份、白芍10份、乌梅肉15份、大腹皮20份、泽泻10份、五味子5份、巴戟天10份、荷叶1份、葛根叶5份、银柴胡10份、香加皮0.1份、急性子0.5份、蛇床子1份。
作为优选的，这里给出第二个具体的配方，所述原料的重量份为：
蒺藜20份、益母草25份、海螵蛸30份、仙人掌20份、大苞芹25份、当归30份、桂圆肉10份、白芍15份、乌梅肉20份、大腹皮10份、泽泻15份、五味子10份、巴戟天1份、荷叶5份、葛根叶10份、银柴胡1份、香加皮0.5份、急性子1份、蛇床子0.1份。
作为优选的，这里给出第三个具体的配方，所述原料的重量份为：
蒺藜25份、益母草30份、海螵蛸20份、仙人掌25份、大苞芹30份、当归20份、桂圆肉15份、白芍20份、乌梅肉10份、大腹皮15份、泽泻20份、五味子1份、巴戟天5份、荷叶10份、葛根叶1份、银柴胡5份、香加皮1份、急性子0.1份、蛇床子0.5份。
本发明还提供上述内服药的制备方法，其步骤如下为：
将原料混合粉碎后，加入其总重2～3倍的水、0.1％～1％的酵母，于35～38℃的条件下发酵5～10天，过滤，滤渣加3～5倍的水，煮沸后保持微沸10～30分钟，过滤，得到的滤液与发酵后过滤得到的滤液合并，加热至60～80℃，合并的滤液中加入其重量1％～3％的蜂蜜、0.01％～0.03％酪蛋白酸钠，喷雾干燥所得颗粒即为所述内服药。
该内服药的使用方法为：加热水溶解后内服，每次服用1～5克，每天3次，14天为一个疗程。
本发明的有益效果是：本发明的原料为常用中草药，来源广泛，价格便宜；本发明制备方法简单易控，药物的配方科学合理，各组分之间协同作用，制得的药物副作用低，具有疏风散寒、辛温通窍、调节血气、行滞化瘀、温肺益气、祛风通窍的功效，能够增强患者体质，有效缓解和改善变应性鼻炎相关病症。
具体实施方式
以下通过实施例进一步说明本发明，但本发明不限于这些实施例。
实施例1
治疗变应性鼻炎的内服药，由下述重量份的原料制得：蒺藜30份、益母草20份、海螵蛸25份、仙人掌30份、大苞芹20份、当归25份、桂圆肉20份、白芍10份、乌梅肉15份、大腹皮20份、泽泻10份、五味子5份、巴戟天10份、荷叶1份、葛根叶5份、银柴胡10份、香加皮0.1份、急性子0.5份、蛇床子1份。
内服药的制备方法为：将原料混合粉碎后，加入其总重2倍的水、0.5％的酵母，于38℃的条件下发酵5天，过滤，滤渣加4倍的水，煮沸后保持微沸30分钟，过滤，得到的滤液与发酵后过滤得到的滤液合并，加热至60℃，合并的滤液中加入其重量2％的蜂蜜、0.03％酪蛋白酸钠，喷雾干燥所得颗粒即为所述内服药。
实施例2
治疗变应性鼻炎的内服药，由下述重量份的原料制得：蒺藜20份、益母草25份、海螵蛸30份、仙人掌20份、大苞芹25份、当归30份、桂圆肉10份、白芍15份、乌梅肉20份、大腹皮10份、泽泻15份、五味子10份、巴戟天1份、荷叶5份、葛根叶10份、银柴胡1份、香加皮0.5份、急性子1份、蛇床子0.1份。
内服药的制备方法为：将原料混合粉碎后，加入其总重2.5倍的水、1％的酵母，于35℃的条件下发酵8天，过滤，滤渣加5倍的水，煮沸后保持微沸10分钟，过滤，得到的滤液与发酵后过滤得到的滤液合并，加热至70℃，合并的滤液中加入其重量3％的蜂蜜、0.01％酪蛋白酸钠，喷雾干燥所得颗粒即为所述内服药。
实施例3
治疗变应性鼻炎的内服药，由下述重量份的原料制得：蒺藜25份、益母草30份、海螵蛸20份、仙人掌25份、大苞芹30份、当归20份、桂圆肉15份、白芍20份、乌梅肉10份、大腹皮15份、泽泻20份、五味子1份、巴戟天5份、荷叶10份、葛根叶1份、银柴胡5份、香加皮1份、急性子0.1份、蛇床子0.5份。
内服药的制备方法为：将原料混合粉碎后，加入其总重3倍的水、0.1％的酵母，于37℃的条件下发酵10天，过滤，滤渣加3倍的水，煮沸后保持微沸20分钟，过滤，得到的滤液与发酵后过滤得到的滤液合并，加热至80℃，合并的滤液中加入其重量1％的蜂蜜、0.02％酪蛋白酸钠，喷雾干燥所得颗粒即为所述内服药。
毒性试验
试验药品是本发明实施例1中的内服药。试验动物为ICR种小白鼠，体重20～22克，雌雄各半，共40只。试验方法是，禁食15小时后，按20克/千克给小白鼠灌胃4个月，长期毒性试验结果显示，小白鼠体重、肝功能、肾功能、血象等与对照组无明显差异，表明该药的安全性大，属于无毒级别。
治疗效果
使用实施例1制得的内服药，对100名消瘦症患者进行试用试验，有效率达到85％。其中：小于20岁的20人中15人疗效显著，4人有一定疗效；20～30岁的20人中10人疗效显著，7人有一定疗效；30～40岁的20人中8人疗效显著，10人有一定疗效；40～50岁的20人中11人疗效显著，5人有一定疗效；大于50岁的20人中7人疗效显著，8人有一定疗效。

Claims (5)

1.治疗变应性鼻炎的内服药，其特征在于，由下述重量份的原料制得：
蒺藜20～30份、益母草20～30份、海螵蛸20～30份、仙人掌20～30份、大苞芹20～30份、当归20～30份、桂圆肉10～20份、白芍10～20份、乌梅肉10～20份、大腹皮10～20份、泽泻10～20份、五味子1～10份、巴戟天1～10份、荷叶1～10份、葛根叶1～10份、银柴胡1～10份、香加皮0.1～1份、急性子0.1～1份、蛇床子0.1～1份。
2.根据权利要求1所述的内服药，其特征在于，所述原料的重量份为：
蒺藜30份、益母草20份、海螵蛸25份、仙人掌30份、大苞芹20份、当归25份、桂圆肉20份、白芍10份、乌梅肉15份、大腹皮20份、泽泻10份、五味子5份、巴戟天10份、荷叶1份、葛根叶5份、银柴胡10份、香加皮0.1份、急性子0.5份、蛇床子1份。
3.根据权利要求1所述的内服药，其特征在于，所述原料的重量份为：
蒺藜20份、益母草25份、海螵蛸30份、仙人掌20份、大苞芹25份、当归30份、桂圆肉10份、白芍15份、乌梅肉20份、大腹皮10份、泽泻15份、五味子10份、巴戟天1份、荷叶5份、葛根叶10份、银柴胡1份、香加皮0.5份、急性子1份、蛇床子0.1份。
4.根据权利要求1所述的内服药，其特征在于，所述原料的重量份为：
蒺藜25份、益母草30份、海螵蛸20份、仙人掌25份、大苞芹30份、当归20份、桂圆肉15份、白芍20份、乌梅肉10份、大腹皮15份、泽泻20份、五味子1份、巴戟天5份、荷叶10份、葛根叶1份、银柴胡5份、香加皮1份、急性子0.1份、蛇床子0.5份。
5.根据权利要求1～4中任一项所述的内服药，其特征在于，该内服药的制备方法为：
将原料混合粉碎后，加入其总重2～3倍的水、0.1％～1％的酵母，于35～38℃的条件下发酵5～10天，过滤，滤渣加3～5倍的水，煮沸后保持微沸10～30分钟，过滤，得到的滤液与发酵后过滤得到的滤液合并，加热至60～80℃，合并的滤液中加入其重量1％～3％的蜂蜜、0.01％～0.03％酪蛋白酸钠，喷雾干燥所得颗粒即为所述内服药。
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