CN105395750A - External use type Chinese herbal medicine prescription for preventing and controlling fish epizoonosis and production method thereof - Google Patents

External use type Chinese herbal medicine prescription for preventing and controlling fish epizoonosis and production method thereof Download PDF

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Publication number
CN105395750A
CN105395750A CN201510826652.5A CN201510826652A CN105395750A CN 105395750 A CN105395750 A CN 105395750A CN 201510826652 A CN201510826652 A CN 201510826652A CN 105395750 A CN105395750 A CN 105395750A
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leaf
fish
herbal medicine
chinese herbal
folium
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谢钦铭
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Jimei University
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Jimei University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/889Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/58Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Farming Of Fish And Shellfish (AREA)

Abstract

The invention discloses an external use type Chinese herbal medicine prescription for preventing and controlling fish epizoonosis and a production method thereof. The prescription is prepared from, by weight, 40-50% of tobacco leaves, 10-25% of areca-nut leaves, 5-10% of radix sophorae flavescentis leaves, 5-10% of melia azedarach leaves, 5-10% of osmunda japonica, 5-10% of Chinese wedelia and 5-10% of maple leaves. The external use type Chinese herbal medicine prescription for treating fish epizoonosis is prepared according to the Chinese herbal medicine compatibility principle and chemical component properties of plant drugs based on the properties of fish epizoonosis. The main principle is that the adhesive action of fish ectozoa is weakened by means of effective constituents in Chinese herbal medicine, and ectozoa adhering to fish is made paralyzed and atrophic and then gets off from fish. Meanwhile, the anti-inflammatory and anti-microbial effective constituents contained in the preparation can repair infected wounds on fish caused by ectozoa, so that disease prevention and treatment are achieved. The preparation can be used in the liquid soaking mode, or the bag hanging diffusion mode, or the whole-pool splashing mode.

Description

A kind of control vermiontic Chinese herbal medicine for external use prescription of Fish and production method thereof
Technical field
The present invention relates to Fish medicine field technology, refer in particular to a kind of control vermiontic Chinese herbal medicine for external use prescription of Fish and production method thereof.
Background technology
The Chinese herbal medicine for external use prescription of existing control Fish epizoa disease is comparatively simple, effect is single, and therapeutic effect is poor, namely be only mostly be main prescription for insecticidal function, and for some parasite can excite by medicine and develop immunity to drugs or more pierce the injury causing more deep layer in fish body, or bring out bacteriosis and the viral treatment of secondary disease and the problem of reparation, the report that there is not yet any medicine or drug prescription relates to.Comprehensive not by compatibility, function is comparatively single, and the action effect of control Fish parasitic disease is limited, and its using method is only the straightforward procedure of immersion or full pool spilling head.
Summary of the invention
In view of this, the present invention is directed to the disappearance of prior art existence, its main purpose is to provide one can effective repellent Fish ectozoa adhewsive action, can effectively solve and treat the parasite be adsorbed on fish body surface again, make it benumb, flaccidity contracts rear self falling, and effectively can make the Chinese medicine formula that fish body infected wound heals rapidly.The present invention's " the control vermiontic Chinese herbal medicine for external use prescription of Fish and production method thereof ", it effectively can solve now existing eliminating fish parasites disease (freshwater fish ichthyophthiriasis, marine fish stimulate cryptocaryoniosis, Epistylis disease etc.), and compatibility is simple, effect is single, the problem of unsatisfactory curative effect, and the present invention simultaneously can treat the pathogenetic bacteria and viral secondary disease infection problems that are caused by parasite.
For achieving the above object, the present invention adopts as purgation technical scheme:
The vermiontic Chinese herbal medicine for external use prescription of a kind of control Fish, include tobacco leaf, also include areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii, the percentage by weight of each composition is respectively: tobacco leaf 40-50%, areca leaf 10-25%, Radix Sophorae Flavescentis leaf 5-10%, Folium Meliae 5-10%, osmund 5-10%, Herbia Wedeliae 5-10%, Folium Alangii 5-10%.
As a kind of preferred version, described tobacco leaf, areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii are the dendritic or graininess of lobate, full branch shape, cutting entirely.
As a kind of preferred version, described tobacco leaf, areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii are that cutting is dendritic, and its length is 1-5cm.
As a kind of preferred version, described tobacco leaf, areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii are graininess, and its granularity is 20-40 order.
Prevent and treat a production method for the vermiontic Chinese herbal medicine for external use prescription of Fish, comprise the following steps:
(1) bake tobacco leaf, areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii, baking temperature is 80 DEG C-100 DEG C;
(2) tobacco leaf after baking, areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii are carried out pulverizing for 20-40 object powder, then carry out mix homogeneously by the percentage by weight of above-mentioned each composition; And drying, sealing are carried out to mixture.
As a kind of preferred version, when carrying out drying to described mixture, baking temperature is 10 DEG C-30 DEG C, and drying time is 9-15 hour, and humidity is 40%-70%.
The present invention compared with prior art has obvious advantage and beneficial effect, specifically, as shown from the above technical solution:
The present invention adds Multiple components with scientific and reasonable ratio, compatibility science, there is the anthelmintic of the characteristics design for Fish ectoparasite disease (ichthyophthiriasis, marine fish stimulate cryptocaryoniosis, Epistylis disease), allow parasite is benumbed, automatically disengage fish body after atrophy, there is the infected wound repaired fish body and caused by parasite simultaneously, thus reach the advantage of diseases prevention and disease cure function, can be medicinal liquid soak, also can full pool spilling head use etc.
Detailed description of the invention
The present invention discloses the vermiontic Chinese herbal medicine for external use prescription of a kind of control Fish, include tobacco leaf, also include areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii, the percentage by weight of each composition is respectively: tobacco leaf 40-50%, areca leaf 10-25%, Radix Sophorae Flavescentis leaf 5-10%, Folium Meliae 5-10%, osmund 5-10%, Herbia Wedeliae 5-10%, Folium Alangii 5-10%.Described tobacco leaf, areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii are the dendritic or graininess of lobate, full branch shape, cutting entirely, and when it for cutting is dendritic, its length is 1-5cm, and when it is graininess, its granularity is 20-40 order.
The present invention also discloses a kind of production method of preventing and treating the vermiontic Chinese herbal medicine for external use prescription of Fish, comprise the following steps:
(1) bake tobacco leaf, areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii, baking temperature is 80 DEG C-100 DEG C;
(2) tobacco leaf after baking, areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii are carried out pulverizing for 20-40 object powder, then carry out mix homogeneously by the percentage by weight of above-mentioned each composition; And drying, sealing are carried out to mixture.When carrying out drying to described mixture, baking temperature is 10 DEG C-30 DEG C, and drying time is 9-15 hour, and humidity is 40%-70%.
By multiple embodiment, the present invention will be described below:
Embodiment 1: tobacco leaf 50 grams, areca leaf 25 grams, 5 grams, Radix Sophorae Flavescentis leaf, Folium Meliae 5 grams, osmund 5 grams, Herbia Wedeliae 5 grams, 5 grams, Folium Alangii.
Embodiment 2: tobacco leaf 40 grams, areca leaf 10 grams, 10 grams, Radix Sophorae Flavescentis leaf, Folium Meliae 10 grams, osmund 10 grams, Herbia Wedeliae 10 grams, 10 grams, Folium Alangii.
Embodiment 3: tobacco leaf 45 grams, areca leaf 15 grams, 8 grams, Radix Sophorae Flavescentis leaf, Folium Meliae 7 grams, osmund 10 grams, Herbia Wedeliae 5 grams, 10 grams, Folium Alangii.
Although the Ingredients Weight of each embodiment is different, the proportion that the weight of each composition accounts for gross weight should control within following ranges: tobacco leaf 40-50%, areca leaf 10-25%, Radix Sophorae Flavescentis leaf 5-10%, Folium Meliae 5-10%, osmund 5-10%, Herbia Wedeliae 5-10%, Folium Alangii 5-10%.
For some using method preferred embodiments of the vermiontic Chinese herbal medicine for external use prescription of above-mentioned obtained control Fish, have employed baking technology and appropriateness pulverize after, the primary benefit agent of each Chinese herbal medicine is easy to stripping, scientific and reasonable supplement formula fully demonstrated main ingredient complementation, altogether molten and interpenetrate, feature all linked with one another, substantially increase anthelmintic, parasite killing and prevent and treat effect that secondary disease substance (pathogenetic bacteria and virus) infects.Directly spill, can to water pollutions, so the large water surface adopts to be hung.
The using method that the present invention prevents and treats Fish vermiontic Chinese herbal medicine for external use prescription is as follows:
1, pond culture control: by the prescription decocting in water of above-mentioned formula after 0.5-1.5 hour, full pool spilling head, full pool spilling head concentration is: 150-300ppm.
2, medicinal liquid soaks: by the prescription decocting in water of above-mentioned formula after 0.5-1.5 hour, by sick fish soaking 20-40 minute in medicinal liquid, medicinal liquid soaking concentration is: 500-1000ppm.
3, flood face cage culture control-PFU method: by the prescription decocting in water of above-mentioned formula after 0.5-1.5 hour, ammonia vinyl acetate block (PFU) (size: length: 10-20cm) leaching will be gathered and draw medicament in a medicament, hang on net cage central authorities or corner, PFU block is immersed in water body, to change dressings every day agent 1 time, continuous 1 week.Drug concentration is: 800-1500ppm.
4, flood face cage culture control-medicated powder hanging bag method: by the granule of the prescription of above-mentioned formula, after curing through 80-100 DEG C, pulverizes as 20-40 object granule, with closeer packed enter above-mentioned mixture 200-1000 gram, hang in net cage.
Application of set prescription prepared by the embodiment of the present invention 1 sees the following form in experiment in pond (full pool spilling head method) observing effect of the parasitic infection of cabrilla.
Group Detect cabrilla mantissa Cryptonucleus insect infection rate is stimulated before test Within 7 days, stimulate cryptonucleus insect infection rate afterwards Parasitic infection rate after 15 days Cure (infecting parasite fish body to reduce) rate
Embodiment 1 group 30 90.0% 23.33% 3.33% 96.3%
Matched group 30 90.0% 93.33% 86.67% 3.7%
Application of set prescription prepared by the embodiment of the present invention 2 sees the following form in test (medicament infusion method) observing effect of the parasitic infection of aquarium cultivation Carassius auratus.
Group Detect Carassius auratus mantissa Little melonworm infection rate before test Little melonworm infection rate after 5 days Parasitic infection rate after 10 days Cure (infecting parasite fish body to reduce) rate
Embodiment 2 groups 15 86.67% 33.33% 6.67% 92.30%
Matched group 15 86.67% 93.33% 100.0% -15.38%
Application of set prescription prepared by the embodiment of the present invention 3 sees the following form in test (hanging bag diffusion method) observing effect of the parasitic infection of Pseudosciaena crocea.
Group Detect Carnis Pseudosciaenae mantissa Cryptonucleus insect infection rate is stimulated before test Within 8 days, stimulate cryptonucleus insect infection rate afterwards Parasitic infection rate after 20 days Cure (infecting parasite fish body to reduce) rate
Embodiment 3 groups 45 90.0% 17.78% 6.67% 92.59%
Matched group 45 90.0% 93.33% 95.55% -6.17%
Test data shows, the treatment rate to ectoparasitic infection of embodiment 1-3 group is more than 90%; Experimental observation also shows, implementing does not have fish kills to occur in the test group of prescription of the present invention, and the phenomenon of death because parasitic infection is serious appears in contrast.
The above, it is only preferred embodiment of the present invention, not technical scope of the present invention is imposed any restrictions, thus every above embodiment is done according to technical spirit of the present invention any trickle amendment, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.

Claims (6)

1. the vermiontic Chinese herbal medicine for external use prescription of control Fish, include tobacco leaf, it is characterized in that: also include areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii, the percentage by weight of each composition is respectively: tobacco leaf 40-50%, areca leaf 10-25%, Radix Sophorae Flavescentis leaf 5-10%, Folium Meliae 5-10%, osmund 5-10%, Herbia Wedeliae 5-10%, Folium Alangii 5-10%.
2. one control Fish vermiontic Chinese herbal medicine for external use prescription according to claim 1, is characterized in that: described tobacco leaf, areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii are lobate, full branch shape entirely, cutting is dendritic or graininess.
3. the vermiontic Chinese herbal medicine for external use prescription of one control Fish according to claim 1, it is characterized in that: described tobacco leaf, areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii are that cutting is dendritic, its length is 1-5cm.
4. the vermiontic Chinese herbal medicine for external use prescription of one control Fish according to claim 1, it is characterized in that: described tobacco leaf, areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii are graininess, its granularity is 20-40 order.
5. a production method for the vermiontic Chinese herbal medicine for external use prescription of control Fish as claimed in claim 1, is characterized in that: comprise the following steps:
(1) bake tobacco leaf, areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii, baking temperature is 80 DEG C-100 DEG C;
(2) tobacco leaf after baking, areca leaf, Radix Sophorae Flavescentis leaf, Folium Meliae, osmund, Herbia Wedeliae and Folium Alangii are carried out pulverizing for 20-40 object powder, then carry out mix homogeneously by the percentage by weight of above-mentioned each composition; And drying, sealing are carried out to mixture.
6. a kind of production method of preventing and treating the vermiontic Chinese herbal medicine for external use prescription of Fish according to claim 5, it is characterized in that: when drying is carried out to described mixture, baking temperature is 10 DEG C-30 DEG C, and drying time is 9-15 hour, and humidity is 40%-70%.
CN201510826652.5A 2015-11-25 2015-11-25 External use type Chinese herbal medicine prescription for preventing and controlling fish epizoonosis and production method thereof Pending CN105395750A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105794693A (en) * 2016-03-22 2016-07-27 五河县金塘水产养殖有限公司金贸园分公司 Breeding method for preventing and controlling sinergsilus of bighead carps
CN105851070A (en) * 2016-04-25 2016-08-17 江苏大学 Application of invasive weed Wedelia trilobata to killing of prodenia litura larva
TWI826039B (en) * 2022-10-12 2023-12-11 慈濟學校財團法人慈濟大學 Pharmaceutical use of piper betle linn. leaf extract for treating or preventing liver cancer

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105794693A (en) * 2016-03-22 2016-07-27 五河县金塘水产养殖有限公司金贸园分公司 Breeding method for preventing and controlling sinergsilus of bighead carps
CN105851070A (en) * 2016-04-25 2016-08-17 江苏大学 Application of invasive weed Wedelia trilobata to killing of prodenia litura larva
CN105851070B (en) * 2016-04-25 2018-11-06 江苏大学 Application of the invasive weed South America wedelia chinensis in killing Spodoptera litura larvae
TWI826039B (en) * 2022-10-12 2023-12-11 慈濟學校財團法人慈濟大學 Pharmaceutical use of piper betle linn. leaf extract for treating or preventing liver cancer

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