CN105381003A - Pearl and natural indigo buccal tablets and preparation method thereof - Google Patents
Pearl and natural indigo buccal tablets and preparation method thereof Download PDFInfo
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- CN105381003A CN105381003A CN201510799109.0A CN201510799109A CN105381003A CN 105381003 A CN105381003 A CN 105381003A CN 201510799109 A CN201510799109 A CN 201510799109A CN 105381003 A CN105381003 A CN 105381003A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Abstract
The invention discloses pearl and natural indigo buccal tablets and a preparation method thereof. The pearl and natural indigo buccal tablets are prepared from traditional Chinese medicine powder obtained through superfine grinding, a filling agent, a flavoring agent, a lubricating agent and a coating agent, wherein the traditional Chinese medicine powder includes pearl powder, bezoar powder, natural indigo powder, borneol powder and talcum powder. The dispersible tablet preparations are prepared by the steps of material preparation, grinding, preparation, and the like. The pearl and natural indigo buccal tablets have the beneficial effects that the pearl and natural indigo buccal tablets have the functions of clearing away heat and toxic materials, diminishing inflammation and relieving pain and promoting granulation and achieving astringency and are used by patients with mouth and tongue sores, recurrent oral ulceration and herpetic stomatitis; the grain sizes of the traditional Chinese medicines can be 1-10mu m and even smaller after grinding by adopting the traditional Chinese medicine superfine grinding technology, so that dissolution and absorption of the preparations can be obviously accelerated, pains of the patients are relieved as soon as possible and curative effects are possibly achieved with smaller dosage; after the medicines are prepared into the buccal tablets, the residence time of the medicines in oral cavities is increased, the acting time of the medicines is lengthened and the curative effects of the medicines are increased; and the buccal tablets also have the advantages of good tastes, quantification in taking, benefit for children to take, convenience in carrying, and the like.
Description
Technical field
the invention belongs to field of traditional Chinese medicine pharmacy, be specifically related to a kind of precious black pigment used by women in ancient times to paint their eyebrows buccal tablet and preparation method thereof.
Background technology
oral ulcer is the common disease of cari oris mucosa, frequently-occurring disease, and the oral ulcer mucosal ulcer traditional Chinese medical science belongs to " erosion of the oral mucosa " category, how to lie prostrate fire by taste, or affection due to external wind and heat, or accumulation of heat in the heart and spleen, or dampness-heat in the liver and gallbladder, and temperature pents up merit caused by the oral cavity.Have the feature of periodicity and burning property pain, once can continue to infect after being partially formed ulcer, cause ulcer local organization inflammation and necrosis, the course of disease is extended, increasing patient suffering, is one of department of stomatology difficult miscellaneous diseases.
at present, existing medicine majority is western medicine, rare Chinese medicine ingredients, and the effect that the drug effect in treatment plays is general, and ingredient can not be made timely and effectively to arrive sufferer place; And containing in the existing medicine of Chinese medicine ingredients, be mostly to utilize the medicine of the noise reduction that relieves inflammation or internal heat to treat, drug effect plays a role slowly, and the medicinal cycle is long, can not meet the need of market.
summary of the invention:
the object of this invention is to provide a kind of heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling, can the dispersible tablets of Chinese medicine and preparation method thereof of rapid-onset.
the object of the present invention is achieved like this.A kind of precious black pigment used by women in ancient times to paint their eyebrows buccal tablet, it is characterized in that: by the Chinese medicine powder through micronizing, filler, correctives, lubricant, coating materials is made, percentage ratio wherein shared by various raw material is: Chinese medicine powder 10 ~ 30%, filler 30 ~ 80%, correctives 0.1 ~ 10%, lubricant 0.05 ~ 1%, coating materials 3 ~ 10%; Described Chinese medicine powder comprises Margarita powder, bovine calculus powder, Indigo Naturalis powder, Borneolum Syntheticum powder, Pulvis Talci.
weight proportion between described Margarita powder, bovine calculus powder, Indigo Naturalis powder, Borneolum Syntheticum powder, Pulvis Talci is Margarita powder 11-15%, bovine calculus powder 3-4%, Indigo Naturalis powder 51-55%, Borneolum Syntheticum powder 6.5-7%, Pulvis Talci 21-25%.
described filler is the mixing of one or more in pregelatinized Starch, mannitol, microcrystalline Cellulose, lactose, sodium chloride, calcium sulfate.
described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence.
described lubricant is the mixing of one or more in magnesium stearate, silicon dioxide, sodium lauryl sulphate.
described coating materials is hypromellose, and model is the mixing of one or more of E5, E6, E15, E50.
the concrete steps of its preparation method are:
step 1, to get the raw materials ready: by above-mentioned quality proportioning, choose the Margarita of high-quality, Calculus Bovis, Indigo Naturalis, Borneolum Syntheticum, Talcum, for subsequent use after remove impurity;
step 2: pulverize: by above-mentioned Chinese medicine: Margarita, Calculus Bovis, Indigo Naturalis, Borneolum Syntheticum, Talcum adopt micronization technology to pulverize, and are ground into the fine powder of 1 μm ~ 10 μm of particle diameters;
step 3, preparation
a. other above-mentioned adjuvants are crossed 80 mesh sieves, for subsequent use;
b. by the above-mentioned Chinese medicine powder through micronizing, filler, correctives, according to the proportioning mix homogeneously of above-mentioned recipe quantity;
c. the material mixed is placed in dry granulating machine, carries out dry granulation;
d. granulate after terminating, get the additional lubricant of 20-40 object granule, mix homogeneously;
e. mixed granule is adopted rotary tablet press, the Hardness Control of tablet machine, between 8.0 ~ 10.0kg/cm2, obtains label;
f. after coating materials ethanol being uniformly dispersed, adding purified water and make it swelling, cross 100 mesh sieves, obtained coating solution; Label is placed in high-efficiency coating machine, and the inlet temperature of adjustment seed-coating machine is 50 ~ 60 DEG C, and temperature of outgoing air is 30 ~ 40 DEG C, and feed flow frequency is 10 ~ 30Hz, and atomizing pressure is 0.18 ~ 0.20Hz, carries out coating, obtained finished product.
weight proportion between described Margarita powder, bovine calculus powder, Indigo Naturalis powder, Borneolum Syntheticum powder, Pulvis Talci is Margarita powder 13.3%, bovine calculus powder 3.6%, Indigo Naturalis powder 53.3%, Borneolum Syntheticum powder 6.8%, Pulvis Talci 23%.
essence in described correctives comprises: flavoring orange essence, orange flavor, Mint Essence.
in the present invention, precious black pigment used by women in ancient times to paint their eyebrows buccal tablet is made up of Margarita, Calculus Bovis, Indigo Naturalis, Borneolum Syntheticum, Talcum medicine, and the party drafts prescription according to the etiological analysis of the traditional Chinese medical science to oral ulcer.Control with heat-clearing and toxic substances removing, help with dampness convergence, change turbid granulation promoting therefore our Margarita, Indigo Naturalis heat-clearing and toxic substances removing, removing the necrotic tissue and promoting granulation, antipruritic pain relieving.Modern pharmacological research shows: Margarita contains several amino acids, and can promote wound healing, Indigo Naturalis has inhibitory action to S. aureus L-forms.This preparation has the features such as nontoxic, free from extraneous odour, nonirritant, and consumption is little, cheap, easy to use, and patient is easy to accept, and is the effective desirable prescription of mucosal ulcer.
in the present invention: the dry pigment that Indigo Naturalis is Song indigo plant, Acanthaceous indigo, polygonum tinctorium ait., the leaf of careless Folium Isatidis and Folium Isatidis are extracted after soaking and adding lime water.This product nature and flavor are salty-cold, return Liver Channel.There is heat-clearing and toxic substances removing, removing heat from blood, effect of arresting convulsion.For maculae caused by violent heat pathogen, heat in blood tells nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.
in the present invention: Calculus Bovis nature and flavor are sweet, cool.GUIXIN, Liver Channel.Have and clear away heart-fire, eliminating phlegm, have one's ideas straightened out, cool liver, endogenous wind stopping, effect of removing toxic substances.For calentura coma, middle wind-phlegm fan, infantile convulsion is twitched, and epilepsy is gone mad, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle.
in the present invention: Margarita property is sweet, salty, cold.GUIXIN, Liver Channel.There is arresting convulsion of calming the nerves, improving eyesight removing nebula, the effect of removing toxic substances and promoting granulation.For insomnia of palpitating with fear, infantile convulsion epilepsy, the raw nebula of order, skin infection is not held back.
in the present invention: Borneolum Syntheticum is pungent, bitter, is slightly cold.GUIXIN, spleen, lung meridian.There is refreshment of having one's ideas straightened out, effect of clearing away heat to alleviate pain.Faint for calentura coma, convulsion, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, and conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.The pharmacological action of Borneolum Syntheticum specifically has: 1. antibacterial action, and Borneolum Syntheticum can suppress or kill the clinical common bacterias such as staphylococcus aureus, beta hemolysis type streptococcus, viridans streptococci, MIC and MBC is respectively 1.0% ~ 1.5% and 1.5% ~ 2.0%.2. antiinflammatory action, the main component Borneolum Syntheticum in Borneolum Syntheticum and isoborneol all can suppress rat paw edema caused by Ovum Gallus domesticus album.3. analgesic effect, after laser burn wound surface directly uses Borneolum Syntheticum, animal model pain threshold is distinguished high 2.78 times and 6.24 times than JINGWANHONG (positive control) and normal saline group (negative control).In the present invention: Talcum is sweet, light, cold.Return bladder, lung, stomach warp.There is inducing diuresis for treating stranguria syndrome, clearing away summer-heat, the effect of damp eliminating sore.For pyretic stranguria, stranguria caused by urinary stone, urinates hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea; External treatment eczema, eczema, miliaria.
beneficial effect of the present invention: the traditional Chinese medicine mouth buccal tablet of a kind of precious black pigment used by women in ancient times to paint their eyebrows of the present invention, has heat-clearing and toxic substances removing, anti-inflammatory analgetic, effect of promoting tissue regeneration by astringents, for aphtha of the mouth and tongue, the patient of recurrent oral ulceration and HSV stomatitis.The present invention adopts Study on Supermicro-pulverization of Traditional Chinese Drugs technology, and the particle diameter after Chinese medicine can be made to pulverize reaches 1 μm ~ 10 μm, even less, obviously can accelerate the solution absorption of preparation, make patient remove slight illness as early as possible, and likely reach curative effect with smaller dose.After being made into buccal tablet, adding medicine in the intraoral time of staying, make the extended durations of action of medicine, increase the curative effect of medicine, and the mouthfeel that buccal tablet also has is good, take quantitatively, be beneficial to child administration, the advantage such as be easy to carry.
clinical efficacy: it is routine that the present invention is used for recurrent oral ulceration, herpes simplex stomatitis, traumatic oral ulcer etc. 325, obtains promising result.Wherein recurrent oral ulceration 298 example, effective 194 examples, account for this group case 65.10%; Effective 89 examples, account for 29.87%; Invalid 15 examples, account for 5.03%; Total effective rate is 94.97%.Herpes simplex stomatitis etc. 27 example, effective 13 examples, effective 11 examples, invalid 3 examples, total effective rate 88.89%.
technological advantage of the present invention is 1, selects raw material science, and production technology is advanced, and its product is conveniently deposited; 2, do not add spice and antiseptic in product, keep the active ingredient of raw material own, be easily absorbed by the body; 3, raw material sources are extensive, add process line short, the easy processing and manufacturing of product.
Detailed description of the invention
below in conjunction with specific embodiment, the present invention is further illustrated
embodiment 1
a kind of precious black pigment used by women in ancient times to paint their eyebrows buccal tablet, it is characterized in that: by the Chinese medicine powder through micronizing, filler, correctives, lubricant and coating materials are made, and the percentage ratio wherein shared by various raw material is: Chinese medicine powder 10 ~ 30%, filler 30 ~ 80%, correctives 0.1 ~ 10%, lubricant 0.05 ~ 1%, coating materials 3 ~ 10%; Described Chinese medicine powder comprises Margarita powder, bovine calculus powder, Indigo Naturalis powder, Borneolum Syntheticum powder, Pulvis Talci.
embodiment 2
weight proportion between described Margarita powder, bovine calculus powder, Indigo Naturalis powder, Borneolum Syntheticum powder, Pulvis Talci is Margarita powder 11-15%, bovine calculus powder 3-4%, Indigo Naturalis powder 51-55%, Borneolum Syntheticum powder 6.5-7%, Pulvis Talci 21-25%.
embodiment 3
described filler is the mixing of one or more in pregelatinized Starch, mannitol, microcrystalline Cellulose, lactose, sodium chloride, calcium sulfate.
embodiment 4
described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence.
embodiment 5
described lubricant is the mixing of one or more in magnesium stearate, silicon dioxide, sodium lauryl sulphate.
embodiment 6
described coating materials is hypromellose, and model is the mixing of one or more of E5, E6, E15, E50.
embodiment 7
the concrete steps of its preparation method are:
step 1, to get the raw materials ready: by above-mentioned quality proportioning, choose the Margarita of high-quality, Calculus Bovis, Indigo Naturalis, Borneolum Syntheticum, Talcum, for subsequent use after remove impurity;
step 2: pulverize: by above-mentioned Chinese medicine: Margarita, Calculus Bovis, Indigo Naturalis, Borneolum Syntheticum, Talcum adopt micronization technology to pulverize, and are ground into the fine powder of 1 μm ~ 10 μm of particle diameters;
step 3, preparation
a. other above-mentioned adjuvants are crossed 80 mesh sieves, for subsequent use;
b. by the above-mentioned Chinese medicine powder through micronizing, filler, correctives, according to the proportioning mix homogeneously of above-mentioned recipe quantity;
c. the material mixed is placed in dry granulating machine, carries out dry granulation;
d. granulate after terminating, get the additional lubricant of 20-40 object granule, mix homogeneously;
e. mixed granule is adopted rotary tablet press, the Hardness Control of tablet machine, between 8.010.0kg/cm2, obtains label;
f. after coating materials ethanol being uniformly dispersed, adding purified water and make it swelling, cross 100 mesh sieves, obtained coating solution; Label is placed in high-efficiency coating machine, and the inlet temperature of adjustment seed-coating machine is 50 ~ 60 DEG C, and temperature of outgoing air is 30 ~ 40 DEG C, and feed flow frequency is 10 ~ 30Hz, and atomizing pressure is 0.18 ~ 0.20Hz, carries out coating, obtained finished product.
embodiment 8
weight proportion between described Margarita powder, bovine calculus powder, Indigo Naturalis powder, Borneolum Syntheticum powder, Pulvis Talci is Margarita powder 13.3%, bovine calculus powder 3.6%, Indigo Naturalis powder 53.3%, Borneolum Syntheticum powder 6.8%, Pulvis Talci 23%.
embodiment 9
essence in described correctives comprises: flavoring orange essence, orange flavor, Mint Essence.
Claims (9)
1. a precious black pigment used by women in ancient times to paint their eyebrows buccal tablet, it is characterized in that: by the Chinese medicine powder through micronizing, filler, correctives, lubricant, coating materials is made, percentage ratio wherein shared by various raw material is: Chinese medicine powder 10 ~ 30%, filler 30 ~ 80%, correctives 0.1 ~ 10%, lubricant 0.05 ~ 1%, coating materials 3 ~ 10%; Described Chinese medicine powder comprises Margarita powder, bovine calculus powder, Indigo Naturalis powder, Borneolum Syntheticum powder, Pulvis Talci.
2. the precious black pigment used by women in ancient times to paint their eyebrows buccal tablet of one according to claim 1, is characterized in that: the weight proportion between described Margarita powder, bovine calculus powder, Indigo Naturalis powder, Borneolum Syntheticum powder, Pulvis Talci is Margarita powder 11 ~ 15%, bovine calculus powder 3 ~ 4%, Indigo Naturalis powder 51 ~ 55%, Borneolum Syntheticum powder 6.5 ~ 7%, Pulvis Talci 21 ~ 25%.
3. the precious black pigment used by women in ancient times to paint their eyebrows buccal tablet of one according to claim 1 described in, is characterized in that: described filler is the mixing of one or more in pregelatinized Starch, mannitol, microcrystalline Cellulose, lactose, sodium chloride, calcium sulfate.
4. the precious black pigment used by women in ancient times to paint their eyebrows buccal tablet of one according to claim 1, is characterized in that: described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence.
5. the precious black pigment used by women in ancient times to paint their eyebrows buccal tablet of one according to claim 1, is characterized in that: described lubricant is the mixing of one or more in magnesium stearate, silicon dioxide, sodium lauryl sulphate.
6. the precious black pigment used by women in ancient times to paint their eyebrows buccal tablet of one according to claim 1, it is characterized in that: described coating materials is hypromellose, model is the mixing of one or more of E5, E6, E15, E50.
7. the preparation method of a kind of precious black pigment used by women in ancient times to paint their eyebrows buccal tablet according to claim 1, is characterized in that: the concrete steps of its preparation method are:
Step 1, to get the raw materials ready: by above-mentioned quality proportioning, choose the Margarita of high-quality, Calculus Bovis, Indigo Naturalis, Borneolum Syntheticum, Talcum, for subsequent use after remove impurity;
Step 2: pulverize: by above-mentioned Chinese medicine: Margarita, Calculus Bovis, Indigo Naturalis, Borneolum Syntheticum, Talcum adopt micronization technology to pulverize, and are ground into the fine powder of 1 μm ~ 10 μm of particle diameters;
Step 3, preparation
A. other above-mentioned adjuvants are crossed 80 mesh sieves, for subsequent use;
B. by the above-mentioned Chinese medicine powder through micronizing, filler, correctives, according to the proportioning mix homogeneously of above-mentioned recipe quantity;
C. the material mixed is placed in dry granulating machine, carries out dry granulation;
D. granulate after terminating, get the additional lubricant of 20 ~ 40 object granule, mix homogeneously;
E. mixed granule is adopted rotary tablet press, the Hardness Control of tablet machine, between 8.010.0kg/cm2, obtains label;
F. after coating materials ethanol being uniformly dispersed, adding purified water and make it swelling, cross 100 mesh sieves, obtained coating solution; Label is placed in high-efficiency coating machine, and the inlet temperature of adjustment seed-coating machine is 50 ~ 60 DEG C, and temperature of outgoing air is 30 ~ 40 DEG C, and feed flow frequency is 10 ~ 30Hz, and atomizing pressure is 0.18 ~ 0.20Hz, carries out coating, obtained finished product.
8. the precious black pigment used by women in ancient times to paint their eyebrows buccal tablet of one according to claim 2, is characterized in that: the weight proportion between described Margarita powder, bovine calculus powder, Indigo Naturalis powder, Borneolum Syntheticum powder, Pulvis Talci is Margarita powder 13.3%, bovine calculus powder 3.6%, Indigo Naturalis powder 53.3%, Borneolum Syntheticum powder 6.8%, Pulvis Talci 23%.
9. the precious black pigment used by women in ancient times to paint their eyebrows buccal tablet of one according to claim 4, is characterized in that: the essence in described correctives comprises: flavoring orange essence, orange flavor, Mint Essence.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510799109.0A CN105381003A (en) | 2015-11-19 | 2015-11-19 | Pearl and natural indigo buccal tablets and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510799109.0A CN105381003A (en) | 2015-11-19 | 2015-11-19 | Pearl and natural indigo buccal tablets and preparation method thereof |
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| CN105381003A true CN105381003A (en) | 2016-03-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510799109.0A Withdrawn CN105381003A (en) | 2015-11-19 | 2015-11-19 | Pearl and natural indigo buccal tablets and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112336786A (en) * | 2019-08-08 | 2021-02-09 | 北京杨宪青中医药文化院 | Bezoar musk aphtha powder and preparation method thereof |
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| CN1368303A (en) * | 2001-02-06 | 2002-09-11 | 杨孟君 | Nano medicine 'Zhendai' and its preparing process |
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| CN112336786A (en) * | 2019-08-08 | 2021-02-09 | 北京杨宪青中医药文化院 | Bezoar musk aphtha powder and preparation method thereof |
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Application publication date: 20160309 |