CN103919920A - Buccal tablet retaining original ecology of wolfberry fruits and preparation process thereof - Google Patents
Buccal tablet retaining original ecology of wolfberry fruits and preparation process thereof Download PDFInfo
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Abstract
The invention discloses a buccal tablet retaining original ecology of wolfberry fruits and a preparation process thereof. The buccal tablet retaining the original ecology of the wolfberry fruit is prepared from the following raw materials: traditional Chinese medicine wolfberry fruits and an auxiliary material, wherein the component of the traditional Chinese medicine wolfberry fruits is 120g, and the auxiliary material comprises the following components by weight: 1g-50g of medicinal calcium hydrophosphate, 10g-200g of cane sugar or 10g-200g of xylitol, 1g-20g of vitamin C, 5g-10g of povidone, 10g-20g of gelatin, 0.1g-2.0g of menthol, 0.01g-0.02g of aspartame, 0.5g-1.0g of micro-powder, 1g-5g of talcum powder and 0.1g-2.0g of magnesium stearate. The buccal tablet retaining the original ecology of the wolfberry fruits is simple to prepare and convenient to use; and meanwhile, 40g-60g of hydroxypropyl methyl cellulose is used for preparing a film coating, so that the stability and quality of a product are improved.
Description
Technical field
The invention belongs to medicine and health food technology field, relate to a kind of buccal tablet and preparation technology thereof who keeps Fructus Lycii ecosystem.
Background technology
Along with the fast development of China's economy, living standards of the people improve day by day in recent years, being growing more intense of the market competition, nourishing healthy, the beauty treatment of people to self and to adjust the requirement of the aspects such as function more and more stronger.Integration of edible and medicinal herbs development of new food products should be elected people's urgent needs as, effect uniqueness and novel new Food and hygienical food, in Fructus Lycii, contain multiple nutrients, chemical composition, there is abundant nutritive value and special medical care effect, that medicine-food two-purpose foodstuff raw material is as the abundant pure natural health-care of nutritional labeling, there is tonifying liver, kidney tonifying, improving eyesight the kidney invigorating nourishing the liver, lung moistening improving eyesight, enhancing immunity, anti-aging, antitumor, antioxidation, the function of resisting fatigue, for asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, the dizzy disease such as not clear, because Fructus Lycii is worth and medical care effect, cause people's extensive concern.But because Chinese wolfberry fruit is less, carry and eat inconvenience, people are edible not general for Fructus Lycii.At present, although there has been the product taking Fructus Lycii as raw material on market, these products contain Fructus Lycii and become less, and carry and eat with all inconvenient.
Summary of the invention
It is simple that the technical problem to be solved in the present invention is to provide a kind of technique, instant, a kind of buccal tablet that keeps Fructus Lycii ecosystem that product stability is good, be easy to control product quality.
For solving the problems of the technologies described above, the present invention adopts following technical scheme: the buccal tablet of described maintenance Fructus Lycii ecosystem is made up of following raw material: Chinese medicine Fructus Lycii and adjuvant, the component of described Chinese medicine Fructus Lycii and parts by weight proportioning are: 120g Fructus Lycii, described adjuvant component and parts by weight proportioning are: the medicinal calcium hydrogen phosphate of 1 ~ 50g, 10 ~ 200g sucrose or 10 ~ 200g xylitol, 1 ~ 20g vitamin C, 5 ~ 10g polyvidone, 10 ~ 20g gelatin, 0.1 ~ 2.0g Mentholum, 0.01 ~ 0.02g aspartame, 0.5 ~ 1.0g micropowder silica gel, 1 ~ 5g Pulvis Talci, 0.1 ~ 2.0g magnesium stearate, 40 ~ 60g hydroxypropyl methylcellulose.
Another technical problem that the present invention will solve is to provide a kind of preparation technology of the buccal tablet that keeps Fructus Lycii ecosystem.
For solving the problems of the technologies described above, the present invention adopts following technical scheme: comprise the following steps:
1) proportioning is extracted 120 g Fructus Lycii by weight, the medicinal calcium hydrogen phosphate of 1 ~ 50g was pulverized 60 ~ 80 mesh sieves jointly;
2) get powder in step 1) and cross 10 ~ 200g sucrose of 80 mesh sieves or cross 10 ~ 200g xylitol of 80 mesh sieves and 1 ~ 20g vitamin C, 5 ~ 10g polyvidone, mix homogeneously;
3) get step 2) in the powder of mix homogeneously add the gelatin solution of 10 ~ 20g 10%, stir, make soft material, 16 mesh sieves are granulated, 50～80 DEG C dry, through 16 mesh sieve granulate;
4) powder of getting in step 3) adds 0.1 ~ 2.0g Mentholum, 0.01 ~ 0.02g aspartame, 0.5 ~ 1.0g micropowder silica gel, 1 ~ 5g Pulvis Talci and 0.1 ~ 2.0g magnesium stearate, mix homogeneously, and tabletting, the punch die adopting when tabletting is circular piece and Special-shaped sheet, and Special-shaped sheet comprises: capsule-type, rhombus or triangle;
5) tablet 40 ~ 60g hydroxypropyl methylcellulose of getting gained in step 4) is made film-coat material, packs film-coat, gets product.
The buccal tablet of maintenance Fructus Lycii ecosystem of the present invention, the efficacy effect of its raw material and adjuvant is respectively:
1, Fructus Lycii: the kidney invigorating nourishing the liver, lung moistening improving eyesight, enhancing immunity, anti-aging, antitumor, antioxidation, resisting fatigue, anti-cancer, for asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, the dizzy disease such as not clear; 2, medicinal calcium hydrogen phosphate: mainly as calsium supplement, be simultaneously used as the diluent of capsule and tablet; 3, cane sugar powder: sweeting agent; 4, xylitol: sweeting agent, there is the liver function of improvement and anticariogenic effect, do diabetes patient's sweeting agent, supplementary and auxiliary therapeutical agent; 5, vitamin C: there is prevention gingival atrophy, prevention of arterial sclerosis, anti-cancer, treats anemia, and treatment vitamin C deficiency promotes the synthetic of collagen protein, improves the immunity of human body and effect of raising body emergency capability; 6, polyvidone: can be used for tablet, granule, the multiple drug form such as water preparation, has removing toxic substances, stops blooding, improves concentration of ordinary dissolution, prevents peritoneal adhesion, promotes the effects such as erythrocyte sedimentation rate; 7, gelatin: hemostasis, cure mainly haematemesis, epistaxis, has blood in stool, the diseases such as metrorrhagia, and there is the multifrequency natures such as gelation, solid water, caking property and dissolubility; 8, Mentholum: as excitants, for skin or mucosa, there is refrigerant itching-relieving action pharmaceutically, the carminative that can be used as for oral administration, for headache and nose, pharynx, laryngitis etc.; 9, aspartame: sweeting agent, additive; 10, micropowder silica gel: as adjuvant, improve mobility of particle in pharmaceuticals industry; 11, Pulvis Talci: inducing diuresis for treating stranguria syndrome, clearing away summer-heat, damp eliminating sore, for pyretic stranguria, stranguria caused by urinary stone, urinate hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea, external treatment eczema, eczema, miliaria, and it is good to have capacitive when the additive, and glossiness is strong, taste softness, the feature that smoothness is strong; 12, magnesium stearate: main as tablet in medicament, the lubricants such as capsule, fluidizer or antiplastering aid; 13, hydroxypropyl methylcellulose: pharmaceuticals industry is used as coating material, film material, the control speed polymeric material of slow releasing preparation, stabilizing agent, suspending agent, tablet binder, tackifier.
The beneficial effect of a kind of buccal tablet that keeps Fructus Lycii ecosystem of the present invention is: scalable body's immunity, can effectively suppress tumor growth and cell mutation, there is slow down aging, anti-fatty liver, regulate the effect of the aspects such as blood fat and blood glucose, and can strengthen leukocyte activity, suppress fat deposits in hepatocyte, promote hepatocyte new life's effect, to chronic hepatitis, central serous chorioretinopathy, optic atrophys etc. are evident in efficacy, also can blood pressure lowering, blood sugar lowering, blood fat reducing, and the physical and chemical index of the prepared Fructus Lycii buccal tablet of the present invention is the research with colorimetric method for determining betaine in lycium Chinese content, the method adopting has specificity, be easy to control product quality.
Brief description of the drawings
Fig. 1 is the moisture equilibrium at dry side figure of a kind of buccal tablet that keeps Fructus Lycii ecosystem of the present invention.
Detailed description of the invention
For the concrete function that can further understand feature of the present invention, technological means and reach, with detailed description of the invention, the present invention is described in further detail below.
EXAMPLE l
A kind of buccal tablet that keeps Fructus Lycii ecosystem of the present invention, the buccal tablet of described maintenance Fructus Lycii ecosystem is made up of following raw material: Chinese medicine Fructus Lycii and adjuvant, the component of described Chinese medicine Fructus Lycii and parts by weight proportioning are: 120g Fructus Lycii, described adjuvant component and parts by weight proportioning are: the medicinal calcium hydrogen phosphate of 1g, 10g sucrose, 1g vitamin C, 5g polyvidone, 10g gelatin, 0.1g Mentholum, 0.01g aspartame, 0.5g micropowder silica gel, 1g Pulvis Talci, 0.1g magnesium stearate, 40g hydroxypropyl methylcellulose.
The preparation process of described a kind of buccal tablet that keeps Fructus Lycii ecosystem is as follows:
1) proportioning is extracted 120 g Fructus Lycii by weight, the medicinal calcium hydrogen phosphate of 1g was pulverized 60 ~ 80 mesh sieves jointly;
2) get powder in step 1) and cross the 10g sucrose of 80 mesh sieves and 1g vitamin C, 5g polyvidone, mix homogeneously;
3) get step 2) in the powder of mix homogeneously add the gelatin solution of 10g 10%, stir, make soft material, 16 mesh sieves are granulated, 50～80 DEG C dry, through 16 mesh sieve granulate;
4) powder of getting in step 3) adds 0.1g Mentholum, 0.01g aspartame, 0.5g micropowder silica gel, 1g Pulvis Talci and 0.1g magnesium stearate, mix homogeneously, and tabletting, the punch die adopting when tabletting is circular piece and Special-shaped sheet, Special-shaped sheet comprises: capsule-type, rhombus or triangle;
5) the tablet 40g hydroxypropyl methylcellulose of getting gained in step 4) is made film-coat material, packs film-coat, gets product.
Embodiment 2
A kind of buccal tablet that keeps Fructus Lycii ecosystem of the present invention, the buccal tablet of described maintenance Fructus Lycii ecosystem is made up of following raw material: Chinese medicine Fructus Lycii and adjuvant, the component of described Chinese medicine Fructus Lycii and parts by weight proportioning are: 120g Fructus Lycii, described adjuvant component and parts by weight proportioning are: the medicinal calcium hydrogen phosphate of 25g, 95g sucrose, 10g vitamin C, 7.5g polyvidone, 15g gelatin, 1g Mentholum, 0.015g aspartame, 0.75g micropowder silica gel, 2.5g Pulvis Talci, 1g magnesium stearate, 50g hydroxypropyl methylcellulose.
The preparation process of described a kind of buccal tablet that keeps Fructus Lycii ecosystem is as follows:
1) proportioning is extracted 120 g Fructus Lycii by weight, the medicinal calcium hydrogen phosphate of 25g was pulverized 60 ~ 80 mesh sieves jointly;
2) get powder in step 1) and cross the 95g sucrose of 80 mesh sieves and 10g vitamin C, 7.5g polyvidone, mix homogeneously;
3) get step 2) in the powder of mix homogeneously add the gelatin solution of 15g 10%, stir, make soft material, 16 mesh sieves are granulated, 50～80 DEG C dry, through 16 mesh sieve granulate;
4) powder of getting in step 3) adds 1g Mentholum, 0.015g aspartame, 0.75g micropowder silica gel, 2.5g Pulvis Talci and 1g magnesium stearate, mix homogeneously, and tabletting, the punch die adopting when tabletting is circular piece and Special-shaped sheet, Special-shaped sheet comprises: capsule-type, rhombus or triangle;
5) the tablet 50g hydroxypropyl methylcellulose of getting gained in step 4) is made film-coat material, packs film-coat, gets product.
Embodiment 3
A kind of buccal tablet that keeps Fructus Lycii ecosystem of the present invention, the buccal tablet of described maintenance Fructus Lycii ecosystem is made up of following raw material: Chinese medicine Fructus Lycii and adjuvant, the component of described Chinese medicine Fructus Lycii and parts by weight proportioning are: 120g Fructus Lycii, described adjuvant component and parts by weight proportioning are: the medicinal calcium hydrogen phosphate of 50g, 200g sucrose, 20g vitamin C, 10g polyvidone, 20g gelatin, 2.0g Mentholum, 0.02g aspartame, 1.0g micropowder silica gel, 5g Pulvis Talci, 2.0g magnesium stearate, 60g hydroxypropyl methylcellulose.
The preparation process of described a kind of buccal tablet that keeps Fructus Lycii ecosystem is as follows:
1) proportioning is extracted 120 g Fructus Lycii by weight, the medicinal calcium hydrogen phosphate of 50g was pulverized 60 ~ 80 mesh sieves jointly;
2) get powder in step 1) and cross the 200g sucrose of 80 mesh sieves and 20g vitamin C, 10g polyvidone, mix homogeneously;
3) get step 2) in the powder of mix homogeneously add the gelatin solution of 20g 10%, stir, make soft material, 16 mesh sieves are granulated, 50～80 DEG C dry, through 16 mesh sieve granulate;
4) powder of getting in step 3) adds 2.0g Mentholum, 0.02g aspartame, 1.0g micropowder silica gel, 5g Pulvis Talci and 2.0g magnesium stearate, mix homogeneously, and tabletting, the punch die adopting when tabletting is circular piece and Special-shaped sheet, Special-shaped sheet comprises: capsule-type, rhombus or triangle;
5) the tablet 60g hydroxypropyl methylcellulose of getting gained in step 4) is made film-coat material, packs film-coat, gets product.
Embodiment 4
A kind of buccal tablet that keeps Fructus Lycii ecosystem of the present invention, the buccal tablet of described maintenance Fructus Lycii ecosystem is made up of following raw material: Chinese medicine Fructus Lycii and adjuvant, the component of described Chinese medicine Fructus Lycii and parts by weight proportioning are: 120g Fructus Lycii, described adjuvant component and parts by weight proportioning are: the medicinal calcium hydrogen phosphate of 1g, 10g xylitol, 1g vitamin C, 5g polyvidone, 10g gelatin, 0.1g Mentholum, 0.01g aspartame, 0.5g micropowder silica gel, 1g Pulvis Talci, 0.1g magnesium stearate, 40g hydroxypropyl methylcellulose.
The preparation process of described a kind of buccal tablet that keeps Fructus Lycii ecosystem is as follows:
1) proportioning is extracted 120 g Fructus Lycii by weight, the medicinal calcium hydrogen phosphate of 1g was pulverized 60 ~ 80 mesh sieves jointly;
2) get powder in step 1) and cross the 10g xylitol of 80 mesh sieves and 1g vitamin C, 5g polyvidone, mix homogeneously;
3) get step 2) in the powder of mix homogeneously add the gelatin solution of 10g 10%, stir, make soft material, 16 mesh sieves are granulated, 50～80 DEG C dry, through 16 mesh sieve granulate;
4) powder of getting in step 3) adds 0.1g Mentholum, 0.01g aspartame, 0.5g micropowder silica gel, 1g Pulvis Talci and 0.1g magnesium stearate, mix homogeneously, and tabletting, the punch die adopting when tabletting is circular piece and Special-shaped sheet, Special-shaped sheet comprises: capsule-type, rhombus or triangle;
5) the tablet 40g hydroxypropyl methylcellulose of getting gained in step 4) is made film-coat material, packs film-coat, gets product.
Embodiment 5
A kind of buccal tablet that keeps Fructus Lycii ecosystem of the present invention, the buccal tablet of described maintenance Fructus Lycii ecosystem is made up of following raw material: Chinese medicine Fructus Lycii and adjuvant, the component of described Chinese medicine Fructus Lycii and parts by weight proportioning are: 120g Fructus Lycii, described adjuvant component and parts by weight proportioning are: the medicinal calcium hydrogen phosphate of 25g, 95g xylitol, 10g vitamin C, 7.5g polyvidone, 15g gelatin, 1g Mentholum, 0.015g aspartame, 0.75g micropowder silica gel, 2.5g Pulvis Talci, 1g magnesium stearate, 40g hydroxypropyl methylcellulose.
The preparation process of described a kind of buccal tablet that keeps Fructus Lycii ecosystem is as follows:
1) proportioning is extracted 120 g Fructus Lycii by weight, the medicinal calcium hydrogen phosphate of 25g was pulverized 60 ~ 80 mesh sieves jointly;
2) get powder in step 1) and cross the 95g xylitol of 80 mesh sieves and 10g vitamin C, 7.5g polyvidone, mix homogeneously;
3) get step 2) in the powder of mix homogeneously add the gelatin solution of 15g 10%, stir, make soft material, 16 mesh sieves are granulated, 50～80 DEG C dry, through 16 mesh sieve granulate;
4) powder of getting in step 3) adds 1g Mentholum, 0.015g aspartame, 0.75g micropowder silica gel, 2.5g Pulvis Talci and 1g magnesium stearate, mix homogeneously, and tabletting, the punch die adopting when tabletting is circular piece and Special-shaped sheet, Special-shaped sheet comprises: capsule-type, rhombus or triangle;
5) the tablet 40g hydroxypropyl methylcellulose of getting gained in step 4) is made film-coat material, packs film-coat, gets product.
Embodiment 6
A kind of buccal tablet that keeps Fructus Lycii ecosystem of the present invention, the buccal tablet of described maintenance Fructus Lycii ecosystem is made up of following raw material: Chinese medicine Fructus Lycii and adjuvant, the component of described Chinese medicine Fructus Lycii and parts by weight proportioning are: 120g Fructus Lycii, described adjuvant component and parts by weight proportioning are: the medicinal calcium hydrogen phosphate of 50g, 200g xylitol, 20g vitamin C, 10g polyvidone, 20g gelatin, 2.0g Mentholum, 0.02g aspartame, 1.0g micropowder silica gel, 5g Pulvis Talci, 2.0g magnesium stearate, 60g hydroxypropyl methylcellulose.
The preparation process of described a kind of buccal tablet that keeps Fructus Lycii ecosystem is as follows:
1) proportioning is extracted 120 g Fructus Lycii by weight, the medicinal calcium hydrogen phosphate of 50g was pulverized 60 ~ 80 mesh sieves jointly;
2) get powder in step 1) and cross the 200g xylitol of 80 mesh sieves and 20g vitamin C, 10g polyvidone, mix homogeneously;
3) get step 2) in the powder of mix homogeneously add the gelatin solution of 20g 10%, stir, make soft material, 16 mesh sieves are granulated, 50～80 DEG C dry, through 16 mesh sieve granulate;
4) powder of getting in step 3) adds 2.0g Mentholum, 0.02g aspartame, 1.0g micropowder silica gel, 5g Pulvis Talci and 2.0g magnesium stearate, mix homogeneously, and tabletting, the punch die adopting when tabletting is circular piece and Special-shaped sheet, Special-shaped sheet comprises: capsule-type, rhombus or triangle;
5) the tablet 60g hydroxypropyl methylcellulose of getting gained in step 4) is made film-coat material, packs film-coat, gets product.
Experimental example 1:
The experimental data of adjuvant screening of the present invention:
1, the mensuration of friability: annex of " Chinese Pharmacopoeia " version in 2010 (instrument: CJY-300B matrix agent friability tester, Shanghai Huanghai Sea medicine inspection instrument plant).
Result: measure the buccal tablet of 3 batches, friability is all less than 1%, meets annex regulation of " Chinese Pharmacopoeia " version in 2010.
2, tensile strength: adopt uniform pressure when tabletting and make slice, thin piece size, thickness all consistent.Measure the radially destructive power of slice, thin piece with tablet hardness instrument and evaluate the size of its tensile strength with this.(instrument: YPJ-200B type tablet hardness tester, Shanghai Huanghai Sea medicine inspection instrument plant).
Result: measure the buccal tablet of 3 batches, hardness is at 110 ~ 120N.
3, the investigation of critical relative humidity
Get the saturated salt solution of 8 a series of different relative humiditys of glass exsiccator preparation, as shown in table 1.Get 8 dry weighing botles, precise weighing.Get appropriate Fructus Lycii buccal tablet and be placed in and claim uncovered measuring bottle, then precise weighing (weighing botle and buccal tablet), is placed in the exsiccator of the different relative humiditys of above-mentioned table, and 25 DEG C of constant temperature are placed.Take out and weigh at different time, until quality no longer changes, reach moisture equilibrium at dry side.
Hygroscopicity the results are shown in Table 2, and draws corresponding moisture equilibrium at dry side figure, sees Fig. 1.
Experimental result shows, as shown in Figure 1, at 75% relative humidity once, the moisture absorption hardly of Fructus Lycii buccal tablet.The critical phase of this buccal tablet is to wettability 75%, production process and ambient humidity should being controlled at below 75% while depositing this Fructus Lycii buccal tablet.
4, physical and chemical index is measured
4.1 instruments and reagent ultraviolet-uisible spectrophotometer (U3310 Spectrophotometer Hitachi High-Techologies Corporation); ALC-210.4 type electronic analytical balance (Beijing Sai Duolisi system instrument company limited); KQ-100B type ultrasonic cleaner (Kunshan Ultrasonic Instruments Co., Ltd.); TGL-10B high speed centrifuge (Anting Scientific Instrument Factory, Shanghai); G
3type sintered glass funnel; Betanin reference substance (purity 98%, Acros Organics company); Fructus Lycii buccal tablet (our company's self-control product, 3 batches); Activated carbon powder; 2 mol/L hydrochloric acid solutions; Absolute ether, 70% acetone soln; 3% Reinecke salt: take 3 g Reinecke salts and be dissolved in 100 mL water, ultrasound wave dissolves 30 min, filters (matching while using) (note: in physical and chemical index mensuration, agents useful for same is commercially available analytical pure).
4.2 method
4.2.1 the preparation of betanin reference substance solution accurately takes betanin reference substance 100 mg and puts in 10 mL measuring bottles, adds water and is settled to scale, is mixed with the reference substance solution (matching while using) of 10 mg/mL.
4.2.2 10 of Fructus Lycii buccal tablets are got in the preparation of sample solution, put porphyrize in mortar, precision takes this powder 1.0 g and puts in 100 mL centrifuge tubes, adds 50 mL water, supersound extraction 2 min, add 0.5 g active carbon jolting even, put micro-10 min that boil of boiling water bath heating, take out cooling, divide and get supernatant 20 mL with centrifugal 5 min of 4000 r/min, adjust pH to be about 1 with 2 mol/L hydrochloric acid solutions, add 3% Reinecke salt 20 mL, under 4 DEG C of conditions, ageing 3 h first use G after taking out
3type sintered glass funnel sucking filtration, then, by absolute ether drip washing precipitation, until leacheate is colourless, finally uses 70% acetone soln dissolution precipitation, quantitatively shifts as in 25 mL measuring bottles, and is settled to scale with 70% acetone soln, to be measured.
4.2.3 working curve is prepared respectively series standard working solution by 10 mg/mL betanin reference substance solution, by each concentration standard working solution moisturizing to 20 mL, making its concentration is 0,0.1,0.15,0.2,0.25,0.3,0.4,0.5,0.8 and 1.0 mg/mL, adjust pH to be about 1 with 2 mol/L hydrochloric acid solutions again, add 3% Reinecke salt 20 mL, ageing, all the other steps are with " under 4.2.2 item " sample treatment.
4.2.4 assay, taking 70% acetone soln as blank, in wavelength 525 nm place working sample solution light absorption values, and calculates content.
Experimental example 2:
Experimental subject: 120 participate in experimenter.
Experimental technique and time: allow 120 participation experimenters take the buccal tablet of maintenance Fructus Lycii ecosystem of the present invention, experimental period one month, and after experiment completes, carry out questionnaire survey.
Experimental result: wherein, feel that after taking, health has 97 people than the number that more has energy immunity to be improved in the past, feel that after taking, health has 16 people than the number that had a little in the past energy soreness of waist and knee joint or vertigo and tinnitus phenomenon to disappear, feel that after taking, health has 7 people without the number of significant change; And feeling to take number very easily has 101 people, feeling to take number comparatively easily has 13 people, and feeling to take inconvenient number has 6 people.
Experimental result can obtain thus, and a kind of buccal tablet that keeps Fructus Lycii ecosystem of the present invention has good health-care effect and convenience.
Typical case:
Zhang, female, 25 years old, usually feel soreness of waist and knee joint, vertigo and tinnitus, whole people's lassitude, after taken after a kind of buccal tablet that keeps Fructus Lycii ecosystem of the present invention, soreness of waist and knee joint, the phenomenon of vertigo and tinnitus slowly disappears, and the multiplication of whole people's energy.
Below the present invention is described in detail, the above, be only the present invention's preferred embodiment, when not limiting the scope of the present invention, allly does impartial variation and modification according to the application's scope, all should still belong in covering scope of the present invention.
Claims (2)
1. one kind keeps the buccal tablet of Fructus Lycii ecosystem, it is characterized in that: the buccal tablet of described maintenance Fructus Lycii ecosystem is made up of following raw material: Chinese medicine Fructus Lycii and adjuvant, the component of described Chinese medicine Fructus Lycii and parts by weight proportioning are: 120g Fructus Lycii, described adjuvant component and parts by weight proportioning are: the medicinal calcium hydrogen phosphate of 1 ~ 50g, 10 ~ 200g sucrose or 10 ~ 200g xylitol, 1 ~ 20g vitamin C, 5 ~ 10g polyvidone, 10 ~ 20g gelatin, 0.1 ~ 2.0g Mentholum, 0.01 ~ 0.02g aspartame, 0.5 ~ 1.0g micropowder silica gel, 1 ~ 5g Pulvis Talci, 0.1 ~ 2.0g magnesium stearate, 40 ~ 60g hydroxypropyl methylcellulose.
2. a preparation technology for a kind of buccal tablet that keeps Fructus Lycii ecosystem as claimed in claim 1, is characterized in that: comprise the following steps:
1) proportioning is extracted 120 g Fructus Lycii by weight, the medicinal calcium hydrogen phosphate of 1 ~ 50g was pulverized 60 ~ 80 mesh sieves jointly;
2) get powder in step 1) and cross 10 ~ 200g sucrose of 80 mesh sieves or cross 10 ~ 200g xylitol of 80 mesh sieves and 1 ~ 20g vitamin C, 5 ~ 10g polyvidone, mix homogeneously;
3) get step 2) in the powder of mix homogeneously add the gelatin solution of 10 ~ 20g 10%, stir, make soft material, 16 mesh sieves are granulated, 50～80 DEG C dry, through 16 mesh sieve granulate;
4) powder of getting in step 3) adds 0.1 ~ 2.0g Mentholum, 0.01 ~ 0.02g aspartame, 0.5 ~ 1.0g micropowder silica gel, 1 ~ 5g Pulvis Talci and 0.1 ~ 2.0g magnesium stearate, mix homogeneously, and tabletting, the punch die adopting when tabletting is circular piece and Special-shaped sheet, and Special-shaped sheet comprises: capsule-type, rhombus or triangle;
5) tablet 40 ~ 60g hydroxypropyl methylcellulose of getting gained in step 4) is made film-coat material, packs film-coat, gets product.
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| CN108185438A (en) * | 2017-12-22 | 2018-06-22 | 中国科学院西北高原生物研究所 | The tabletting of black fruit fructus lycii powder and its preparation process |
| CN109662315A (en) * | 2019-02-21 | 2019-04-23 | 宁夏红中宁枸杞制品有限公司 | The wolfberry chewable tablet and preparation method thereof of forced for vitamins C |
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| CN110024985A (en) * | 2019-04-16 | 2019-07-19 | 宁夏红中宁枸杞制品有限公司 | Selenium-enriched wolfberry fruit chewable tablets and preparation method thereof |
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| CN105192606A (en) * | 2015-10-21 | 2015-12-30 | 宁夏林业研究所股份有限公司 | Preparation method of leaf Lycium chinense Miller buccal tablet |
| CN105381003A (en) * | 2015-11-19 | 2016-03-09 | 哈尔滨圣吉药业股份有限公司 | Pearl and natural indigo buccal tablets and preparation method thereof |
| CN106942448A (en) * | 2016-01-06 | 2017-07-14 | 崔世轩 | A kind of preparation method of Sugarless type matrimony vine freeze-dried powder pressed candy |
| CN107625913A (en) * | 2017-09-29 | 2018-01-26 | 杞源堂（宁夏）生物科技有限公司 | A kind of red matrimony vine lozenge of selenium-rich and preparation method thereof |
| CN107751871A (en) * | 2017-09-29 | 2018-03-06 | 杞源堂（宁夏）生物科技有限公司 | A kind of selenium-rich lycium ruthenicum lozenge and preparation method thereof |
| CN108185438A (en) * | 2017-12-22 | 2018-06-22 | 中国科学院西北高原生物研究所 | The tabletting of black fruit fructus lycii powder and its preparation process |
| CN109662315A (en) * | 2019-02-21 | 2019-04-23 | 宁夏红中宁枸杞制品有限公司 | The wolfberry chewable tablet and preparation method thereof of forced for vitamins C |
| CN109805147A (en) * | 2019-02-25 | 2019-05-28 | 青海淼塔源农牧科技有限公司 | A kind of red medlar polysaccharide chewable tablet and its preparation process |
| CN110024985A (en) * | 2019-04-16 | 2019-07-19 | 宁夏红中宁枸杞制品有限公司 | Selenium-enriched wolfberry fruit chewable tablets and preparation method thereof |
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