CN103432223B - Medicament for treating impetigo and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament for treating impetigo and a preparation method thereof. The medicament is mainly prepared from lowigite, minium, verdigris, alum and other drugs according to certain weight ratios. The medicament has functions of detoxifying, promoting tissue regeneration, removing necrotic tissues, promoting wound healing, destroying parasites and diminishing inflammation, and is high in effect taking speed and high in cure rate when used for treating impetigo.

Description

A kind of medicine for the treatment of impetigo and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of impetigo and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Impetigo is born in the pustule of skin, incrustation, stream yellow fluid, and in flakes, pruritus is the dermatosis of main manifestations to contamination.Impetigo, also known as impetigo, pemphigus, is a kind of sending out in skin, infectious suppurative dermatosis.Be characterized in that pustule, pus crusts appear in the exposure portion such as face, extremity: be mainly in summer and autumn, be apt to occur in child, have contagion and self inoculation, easily at nursery school, spread and epidemic in kindergarten or family.At present, because Western medicine cannot rapid, effective treatment impetigo, and have certain side effect, therefore, there is very large demand to the Chinese medicine of rapid, effective treatment impetigo in people.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment impetigo, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating impetigo.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects fibroferritum, Plumbum preparatium, Aerugo, Alumen, Lithargyrum, Radix Aconiti, Oleum Sesami medicine to combine, and is made by these drug regimens each efficacy of drugs produce synergism, thus can the recurrence of fast treating impetigo.Fibroferritum is wherein selected to be that have sterilization, the function of sterilization, controls malignant boil, scabies because its nature and flavor are salty sour and astringent.Select Plumbum preparatium, different name Plumbum preparatium, be because its nature and flavor are pungent salty, cold, poisonous, enter the heart, kidney two warp, have removing toxic substances, granulation promoting, the function of eliminating phlegm down to arrest convulsion, controls carbuncle, ulcer, and incised wound is hemorrhage, aphtha, and soup fire is burnt ， Jing Epilepsy, demented.Aerugo is selected to be because its nature and flavor are sour and astringent, flat, be slightly cold, have nebula removing, removing the necrotic tissue, sore, the function of parasite killing, control cellulitis, hemorrhoid malignant boil, sore throat, ulcerative gingivitis, axil skin ulcer, stubborn dermatitis.Alumen is selected to be because its nature and flavor are sour and astringent, cold, poisonous, enter lung, spleen, stomach, large intestine channel, there is expectorant, dampness, antidiarrheal, removing toxic substances, the function of parasite killing, Zhi epilepsy, sore throat, sputum is stopped up very, hepatitis, jaundice, general edema with yellowish skin, taste-blindness rate, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies, water, fire, insect bite.Lithargyrum is selected to be that flat, poisonous, enter liver, spleen channel, have detumescence parasite killing, restrain anticorrosion, the function of eliminating phlegm down to arrest convulsion, controls hemorrhoid, toxic swelling, ulcer, eczema, bromhidrosis, wound, chronic dysentery ， Jing Epilepsy because its nature and flavor are salty pungent.Select Radix Aconiti to be because its nature and flavor are pungent, heat, poisonous, dispel the wind, cold expelling, dampness, the function of benefiting the fire of the gate of life to invigorate YANG, controls anemofrigid-damp arthralgia, severe and migratory arthralgia pain, spasm of the limbs, trusted subordinate's cold type of pain, Xuan Pi mass in the abdomen.Select Oleum Sesami to be because its nature and flavor are sweet cool, enter meridian of Hand-YANG MING, have moistening dryness for relaxing bowels, the function of removing toxic substances and promoting granulation, control dryness of the intestine constipation, lump swells, ulcer, scabies, chapped skin.

Detailed description of the invention

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following dosage

Fibroferritum 6-10 gram of Plumbum preparatium 8-15 gram of Aerugo 8-15 gram

Alumen 8-15 gram of Lithargyrum 8-15 gram of Radix Aconiti 8-15 gram

Oleum Sesami 40-100 milliliter

Preferable amount is:

Fibroferritum 10 grams, 8 grams of Plumbum preparatiums Aerugo 10 grams

Alumen 10 grams of Lithargyrums 10 grams of Radix Aconiti 10 grams

50 milliliters, Oleum Sesami

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, fibroferritum: forge and be ground into superfine powder;

2, Plumbum preparatium: be placed in iron pan by pure lead and heat, fries dynamic, utilizes air to make it oxidation, is then placed on pulverize in stone mortar, with water rinse, by thickness powder separately, drifts out fine powder, then through being oxidized 24 hours, being ground into fine powder and sieving and get final product;

3, Aerugo: get bronze, brass or copper ware and be long placed in moist place or be sprayed on bronze, brass or copper ware with vinegar, its surface produces dark green patina, after scraping, dry;

4, calcined Alumen: get and pick clean Alumen, puts heating in marmite and dissolves and be calcined to dried-up, take out, chop block, be ground into fine powder;

5, Lithargyrum: get crude drug, removing impurity, is ground into fine powder;

6, Radix Aconiti: pulverization;

7, Oleum Sesami: extract high-quality Oleum Sesami according to quantity.

Two, prepare

The fibroferritum of described weight, Plumbum preparatium, Aerugo, Alumen, Lithargyrum, Radix Aconiti medicine are put into container, mix homogeneously, grinds to form fine powder, add the Oleum Sesami of described consumption, mix homogeneously, stir into ointment.

Medicine of the present invention has removing toxic substances, granulation promoting, removing the necrotic tissue, sore, parasite killing, effect of expectorant, and treatment impetigo instant effect, short treating period, do not recur.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 20, male and female dual-purpose, body weight 2.0-2.5kg, pulls out the rabbit abdominal part rabbit hair, with the cotton swab be immersed in acetic acid in the rabbit abdomen modeling upper 20 second of dialling hair, make rabbit abdominal skin ulcer diameter 10mm, after modeling, rabbit is divided into two groups, wherein one group is test group, and another group is contrast groups, test group uses the ointment stirred to smear, every day 2 times; Contrast groups uses the antiphlogistine that market is sold, and smear 2 every day, after 10 days, test group 10 rabbit are all fully recovered, contrast groups 4 recovery from illness, 6 infection.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient 120 example for medical treatment, wherein male patient 75 example, female patient 45 example.

2, diagnostic criteria

Impetigo is apt to occur in the exposure portion such as women's head-ornaments, extremity, also can spread whole body.Skin lesion, from the beginning of being being dispersed in property erythema or pimple, becomes vesicle very soon, and shape is if the grain of rice is to Semen Glycines size, rapid suppuration muddiness becomes pustule, and around around with slight blush, pustule starts plentiful anxiety, pus deposition after a few hours or 1 ~ 2 day, forms first quarter moon shape empyema phenomenon, now, bleb wall is thin and lax, is easy to break, and exposes the moistening and rotten to the corn skin ulcer face of flushing after broken, flow out yellow fluid, form yellow pus crusts after dry, then crust comes off gradually and heals, preventing from scar more.If pus slime flux elsewhere, can cause new pustule.

3, Therapeutic Method

Select above-mentioned medicament, use to patient, be applied in affected part, early, middle and late each use 1 time, 7 days was a course for the treatment of, took 2 courses for the treatment of continuously every day.

4, efficacy assessment standard

Effective: impetigo is eliminated, physical recovery is normal, without recurring after observing half a year;

Take a turn for the better: impetigo symptom is clearly better, and body constitution obviously recovers;

Invalid: symptom, without improvement, does not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, by Drug therapy impetigo patient 120 example of the present invention, effective 115 examples of result, obvious effective rate is 95.83%, and take a turn for the better 3 examples, and improvement rate is 2.5%, and invalid 2 examples, total effective rate is 98.33%.

Claims (3)

1. treat a medicine for impetigo, it is characterized in that: it is made up of the raw material in following amount ranges:

Fibroferritum 6-10 gram of Plumbum preparatium 8-15 gram of Aerugo 8-15 gram

Alumen 8-15 gram of Lithargyrum 8-15 gram of Radix Aconiti 8-15 gram

Oleum Sesami 40-100 milliliter;

Preparation process is:

(1) get the raw materials ready

(1) fibroferritum: forge and be ground into superfine powder;

(2) Plumbum preparatium: be placed in iron pan by pure lead and heat, fries dynamic, utilizes air to make it oxidation, is then placed on pulverize in stone mortar, with water rinse, by thickness powder separately, drifts out fine powder, then through being oxidized 24 hours, being ground into fine powder and sieving and get final product;

(3) Aerugo: get bronze, brass or copper ware and be long placed in moist place or be sprayed on bronze, brass or copper ware with vinegar, its surface produces dark green patina, after scraping, dry;

(4) calcined Alumen: get and pick clean Alumen, puts heating in marmite and dissolves and be calcined to dried-up, take out, chop block, be ground into fine powder;

(5) Lithargyrum: get crude drug, removing impurity, is ground into fine powder;

(6) Radix Aconiti: pulverization;

(7) Oleum Sesami: extract high-quality Oleum Sesami according to quantity;

(2) prepare

The fibroferritum of described weight, Plumbum preparatium, Aerugo, Alumen, Lithargyrum, Radix Aconiti medicine are put into container, mix homogeneously, grinds to form fine powder, add the Oleum Sesami of described consumption, mix homogeneously, stir into ointment.

2. medicine according to claim 1, wherein the consumption of each raw material is:

Fibroferritum 10 grams, 8 grams of Plumbum preparatiums Aerugo 10 grams

Alumen 10 grams of Lithargyrums 10 grams of Radix Aconiti 10 grams

50 milliliters, Oleum Sesami;

Preparation process is:

(1) get the raw materials ready

(1) fibroferritum: forge and be ground into superfine powder;

(2) Plumbum preparatium: be placed in iron pan by pure lead and heat, fries dynamic, utilizes air to make it oxidation, is then placed on pulverize in stone mortar, with water rinse, by thickness powder separately, drifts out fine powder, then through being oxidized 24 hours, being ground into fine powder and sieving and get final product;

(3) Aerugo: get bronze, brass or copper ware and be long placed in moist place or be sprayed on bronze, brass or copper ware with vinegar, its surface produces dark green patina, after scraping, dry;

(4) calcined Alumen: get and pick clean Alumen, puts heating in marmite and dissolves and be calcined to dried-up, take out, chop block, be ground into fine powder;

(5) Lithargyrum: get crude drug, removing impurity, is ground into fine powder;

(6) Radix Aconiti: pulverization;

(7) Oleum Sesami: extract high-quality Oleum Sesami according to quantity;

(2) prepare

The fibroferritum of described weight, Plumbum preparatium, Aerugo, Alumen, Lithargyrum, Radix Aconiti medicine are put into container, mix homogeneously, grinds to form fine powder, add the Oleum Sesami of described consumption, mix homogeneously, stir into ointment.

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) fibroferritum: forge and be ground into superfine powder;

(2) Plumbum preparatium: be placed in iron pan by pure lead and heat, fries dynamic, utilizes air to make it oxidation, is then placed on pulverize in stone mortar, with water rinse, by thickness powder separately, drifts out fine powder, then through being oxidized 24 hours, being ground into fine powder and sieving and get final product;

(3) Aerugo: get bronze, brass or copper ware and be long placed in moist place or be sprayed on bronze, brass or copper ware with vinegar, its surface produces dark green patina, after scraping, dry;

(4) calcined Alumen: get and pick clean Alumen, puts heating in marmite and dissolves and be calcined to dried-up, take out, chop block, be ground into fine powder;

(5) Lithargyrum: get crude drug, removing impurity, is ground into fine powder;

(6) Radix Aconiti: pulverization;

(7) Oleum Sesami: extract high-quality Oleum Sesami according to quantity;

(2) prepare

The fibroferritum of described weight, Plumbum preparatium, Aerugo, Alumen, Lithargyrum, Radix Aconiti medicine are put into container, mix homogeneously, grinds to form fine powder, add the Oleum Sesami of described consumption, mix homogeneously, stir into ointment.