CN103638176B - A kind of medicine for the treatment of eczema and preparation method thereof - Google Patents
A kind of medicine for the treatment of eczema and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of medicine for the treatment of eczema and preparation method thereof, it is mainly prepared from according to a certain weight ratio by medicines such as Scolopendra, Carnis Anodonta seu crislaria, Folium Artemisiae Argyi, Calamina, Cornu Bubali, Colophonium, Pericarpium Zanthoxyli, Herba Andrographis, Galla Chinensiss, medicine of the present invention has heat-clearing and toxic substances removing, wind-expelling pain-stopping, the function of removing heat from blood detumescence, be used for the treatment of eczema instant effect, good effect, do not recur.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of eczema and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Eczema is a kind of scytitis reaction of the acute pruritus caused by multiple internal and external factor, it is a kind of common anaphylaxis dermatosis, the erythra of a series of lasting and supervention of usual general reference, with rubescent, edema, pruritus and dry be feature, can with forming a scab, peel off, bubble, ftracture, hemorrhage or oozing of blood.Its feature is violent pruritus, and skin lesion pleomorphism is symmetrical, has and oozes out tendency, the chronic course of disease, easy recurrent exerbation.Because Western medicine effectively cannot treat eczema, therefore there is great demand in the Chinese medicine of people to rapid, effective treatment eczema, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment eczema, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment eczema.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Scolopendra, Carnis Anodonta seu crislaria, Folium Artemisiae Argyi, Calamina, Cornu Bubali, Colophonium, Pericarpium Zanthoxyli, Herba Andrographis, Galla Chinensis, Plumbum preparatium, Calomelas, Fructus Evodiae, Squama Manis, pulverized limestone, Mel medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of eczema.Wherein select Scolopendra to be because its nature and flavor are pungent, temperature, poisonous, enter Liver Channel, dispel the wind, arresting convulsion, counteracting toxic substances, the function of eliminating stagnation, controls apoplexy ， Jing Epilepsy, tetanus, pertussis, scrofula, tuberculosis ， mass in the abdomen tumor block, sore swollen toxin, and tinea corporis is bald in vain, anal fistula, scalds.Carnis Anodonta seu crislaria is selected to be that enter liver, kidney channel, have YIN nourishing nourishing the liver, the function of clearing away heat to improve acuity of vision, treating the liver deficiency of the kidney yin, soreness of the waist and knees, eyes is dim-sighted, and tinnitus is dizzy, and eye does many gums because its sweet in the mouth, salty; Yin asthenia generating intrinsic heat, dysphoria with smothery sensation taking fluids profusely, rapid digestion of food and polyorexia, polyuria, menorrhagia, leucorrhea, anal fistula, conjunctival congestion etc.Folium Artemisiae Argyi is selected to be because its nature and flavor toil, temperature.Enter spleen, liver, kidney channel.To regulate the flow of vital energy blood, by cold-damp; Warming the meridian, hemostasis, antiabortive.Control trusted subordinate's cold type of pain, convulsion of having loose bowels, chronic dysentery, tells nosebleed, hematochezia, menoxenia, metrorrhagia, leukorrhagia, frequent fetal movement, carbuncle and ulcer, scabies.Select Calamina to be because its nature and flavor are sweet, temperature, poisonous, enter meridian of Foot-JUE YIN, main tonify deficiency, dry gas, and reason waist foot, removes haemorrhoids, parasite killing.Select Cornu Bubali to be because its nature and flavor hardship is salty, cold, have the function of heat clearing away, removing heat from blood, removing toxic substances, control calentura headache, high fever coma, macule, tells nosebleed, infantile convulsion, sore throat pharyngeal swelling.Select Colophonium to be because its property bitter but sweet flavor, temperature, enter liver, spleen channel, dispel the wind, dampness, evacuation of pus, draw out pus by applying a plaster to the affected part, granulation promoting, the function of pain relieving, controls carbuncle, furunculosis, hemorrhoid complicated by anal fistula, malignant boil, scabies, bald in vain, and incised wound, sprains, rheumatic arthralgia, leprosy pruritus.Pericarpium Zanthoxyli is selected to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, lung, kidney channel, have warming spleen and stomach for dispelling cold, dehumidifying, pain relieving, parasite killing, separate fish raw meat poison, control food stagnation and stop drink, trusted subordinate's cold type of pain, vomiting, oh, cough with dyspnea, anemofrigid-damp arthralgia, has loose bowels, dysentery, colic, toothache, ascariasis, enterobiasis, pudendal pruritus, skin ulcer scabies.Herba Andrographis is selected to be because its nature and flavor are bitter, cold in nature, nontoxic, enter the heart, lung two warp, have heat-clearing and toxic substances removing, the function of removing heat from blood detumescence, controls acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.Galla Chinensis is selected to be because its nature and flavor acid, flat.Enter lung, stomach, large intestine channel.Astringe the lung, astringing intestine to stop diarrhea, hemostasis, removing toxic substances.Control chronic cough of deficiency lung, chronic dysentery, chronic diarrhea, proctoptosis, spontaneous perspiration, night sweat, seminal emission, has blood in stool, epistaxis, metrorrhagia, traumatic hemorrhage, toxic swelling, furuncle, trichiasis.Select Plumbum preparatium, be because its nature and flavor are pungent salty, cold, poisonous, enter the heart, kidney two warp, have removing toxic substances, granulation promoting, the function of eliminating phlegm down to arrest convulsion, controls carbuncle, ulcer, and incised wound is hemorrhage, aphtha, and soup fire is burnt ， Jing Epilepsy, demented.Calomelas is selected to be that cold, poisonous, return liver, kidney, large intestine channel, have counteracting toxic substances, putrefaction removing, the function of parasite killing, festers for skin infection, syphilis, rosacea, neurodermatitis because its nature and flavor are pungent outward; The removing food stagnancy that eliminates the phlegm for oral administration, relieving constipation of relieving oedema or abdominal distension through diuresis or purgation, stagnates for sputum, and edema expands, difficulty in urination and defecation.Select Fructus Evodiae to be because its nature and flavor are worked hard, temperature, poisonous, enter liver, stomach warp, have warming middle-JIAO, pain relieving, regulate the flow of vital energy, the function of dampness, stopping vomiting is against acid regurgitation, and headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.Select Squama Manis to be because its nature and flavor are salty, cool, enter liver, stomach warp, have the routed carbuncle of detumescence, search wind active, the function of stimulating milk secretion of stimulating the menstrual flow, control carbuncle skin ulcer and swell, anemofrigid-damp arthralgia, amenorrhea, galactostasis, external is stopped blooding.Select Calx to be because its nature and flavor are pungent, temperature, poisonous, enter liver, spleen channel, have dampness, parasite killing, hemostasis, analgesic therapy, the function of meat is disliked in erosion, controls scabies, eczema, wound hemorrhage, the burning hot wound of soup, hemorrhoid, proctoptosis, wart.Select Mel to be that flat, enter lung, spleen, large intestine channel, have invigorating middle warmer, moisturize, pain relieving, the function of removing toxic substances, controls xeropulmonary cough, dryness of the intestine constipation, gastralgia, nasal sinusitis, aphtha, the burning hot wound of soup because its nature and flavor are sweet, separate Aconitum Carmichaeli.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight
Scolopendra 1-4 bar Carnis Anodonta seu crislaria 10-20 gram of Folium Artemisiae Argyi 10-20 gram
Calamina 12-22 gram of Cornu Bubali 6-12 gram of Colophonium 8-18 gram
Pericarpium Zanthoxyli 8-20 gram of Herba Andrographis 8-15 gram of Galla Chinensis 9-16 gram
Plumbum preparatium 8-18 gram of Calomelas 4-10 Fructus Evodiae 10-20 gram
Squama Manis 8-18 gram of Calx 8-18 gram of Mel 30-80 gram
Be preferably
Scolopendra 2 Carnis Anodonta seu crislaria 15 grams of Folium Artemisiae Argyis 12 grams
Calamina 15 grams of Cornu Bubalis 10 grams of Colophonium 12 grams
Pericarpium Zanthoxyli 10 grams of Herba Andrographis 10 grams of Galla Chinensiss 10 grams
10 grams, Plumbum preparatium Calomelas, 5 grams of Fructus Evodiaes 12 grams
Squama Manis 15 grams of Calx 15 grams of Mel 50 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Scolopendra: wipe clean, removing cephalopodium, cuts off use;
2, Carnis Anodonta seu crislaria: get fresh and alive mussel, except decapsidate, gets fresh and alive Carnis Anodonta seu crislaria;
3, Folium Artemisiae Argyi: pick decontamination, destemming, sieve dedust bits;
4, Calamina: pick decontamination, smashes;
5, Cornu Bubali: rive, with hot-water soak, pulls out, and pound sheet, dries;
6, Colophonium: put in copper pot, uses low baking temperature heat fused, drags for decontamination, in impouring water, waits cool rear taking-up, dry;
7, Pericarpium Zanthoxyli: removing fruit stem and seed Semen zanthoxyli, to put in pot stir-fry to making sound, oil goes out, take out, cool;
8, Herba Andrographis: removing impurity, wash quickly is clean, slightly moistens, cutting, dry;
9, Galla Chinensis: pick clean, knock open, remove wherein impurity;
10, Plumbum preparatium: be placed in iron pan by pure lead and heat, fries dynamic, utilizes air to make it oxidation, is then placed on pulverize in stone mortar, with water rinse, by thickness powder separately, drifts out fine powder, then through being oxidized 24 hours, being ground into fine powder and sieving and get final product;
11, Calomelas: get crude drug, removing impurity, is ground into fine powder;
12, Fructus Evodiae: get crude drug, removing fruit stem, branch and impurity, sieve removes chip;
13, Squama Manis: get the Squama Manis sheet picking clean, separately size, separately puts sand in pot and makes popular, add Squama Manis sheet, frying to heaving in time golden yellow, taking out, and sieve shakeout, cools;
14, Calx: preparing quick lime, air slaking are powder;
15, Mel: get pure Mel, temper with slow fire, filters skimming.
Two, prepare
1, the Carnis Anodonta seu crislaria that the Scolopendra of described quantity and shelling is taken out is placed in watt dries.
2, the Folium Artemisiae Argyi of the Scolopendra of drying and Carnis Anodonta seu crislaria and described weight, Calamina, Cornu Bubali, Colophonium, Pericarpium Zanthoxyli, Herba Andrographis, Galla Chinensis, Plumbum preparatium, Calomelas, Fructus Evodiae, Squama Manis, Calx medicine are pulverized respectively, grind to the powder altogether.
3, the Mel adding described weight in ground described medicine smalls is mixed well, make paste and get final product.
Medicine of the present invention has the function of heat-clearing and toxic substances removing, wind-expelling pain-stopping, removing heat from blood detumescence, is used for the treatment of eczema instant effect, good effect, does not recur.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.
The animal toxicity test of [test example 1] medicine of the present invention
Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, first exposes skin by rabbit abdominal part hair removing, then by the Herbal medicines for external use that mixes up at rabbit abdominal part baring skin place, then twine with gauze and tie up, once, continuous external application 5 days, observes administration reaction every day in drug of topical application every day, result shows that rabbit is movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's totally 100 examples for medical treatment.
2, diagnostic criteria
Eczema can occur in any position of whole body, is often symmetric, and be generally and be confined to some position, and whole body universal eczema is very rare.Skin lesion shows as pleomorphism, i.e. erythema, pimple, papulovesicle, vesicle, erosion, ooze out, form a scab, the various erythra such as desquamation can cross-reference.That is, in same lesion, in contemporaneity, above-mentioned more than 3 ~ 4 kinds infringements can be there are.Affected part inflammatory reaction is usually comparatively obvious, and especially central part is more remarkable, often with erosion, ooze out.But disease damage indefinite border Chu, swelling is also lighter.
3, Therapeutic Method
Selecting above-mentioned medicament, be applied to affected part to patient, drug of topical application every day 1 time, 15 days is a course for the treatment of, two courses for the treatment of of the continuous drug of topical application.
4, efficacy assessment standard
Effective: eczema symptom is fully recovered, recover normal;
Take a turn for the better: eczema symptom alleviates, and the state of an illness progressively takes a turn for the better;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form):
In above-mentioned treatment, by Drug therapy eczema patients 100 example of the present invention, effective 90 examples of result, obvious effective rate is 90%, and take a turn for the better 3 examples, and improvement rate is 3%, and invalid 7 examples, total effective rate is 93%.
Claims (3)
1. treat a medicine for eczema, it is characterized in that: it is made up of the crude drug in following weight range:
Scolopendra 1-4 bar Carnis Anodonta seu crislaria 10-20 gram of Folium Artemisiae Argyi 10-20 gram
Calamina 12-22 gram of Cornu Bubali 6-12 gram of Colophonium 8-18 gram
Pericarpium Zanthoxyli 8-20 gram of Herba Andrographis 8-15 gram of Galla Chinensis 9-16 gram
Plumbum preparatium 8-18 gram of Calomelas 4-10 Fructus Evodiae 10-20 gram
Squama Manis 8-18 gram of Calx 8-18 gram of Mel 30-80 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Scolopendra 2 Carnis Anodonta seu crislaria 15 grams of Folium Artemisiae Argyis 12 grams
Calamina 15 grams of Cornu Bubalis 10 grams of Colophonium 12 grams
Pericarpium Zanthoxyli 10 grams of Herba Andrographis 10 grams of Galla Chinensiss 10 grams
10 grams, Plumbum preparatium Calomelas, 5 grams of Fructus Evodiaes 12 grams
Squama Manis 15 grams of Calx 15 grams of Mel 50 grams.
3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Scolopendra: wipe clean, removing cephalopodium, cuts off use;
(2) Carnis Anodonta seu crislaria: get fresh and alive mussel, except decapsidate, gets fresh and alive Carnis Anodonta seu crislaria;
(3) Folium Artemisiae Argyi: pick decontamination, destemming, sieve dedust bits;
(4) Calamina: pick decontamination, smashes;
(5) Cornu Bubali: rive, with hot-water soak, pulls out, and pound sheet, dries;
(6) Colophonium: put in copper pot, uses low baking temperature heat fused, drags for decontamination, in impouring water, waits cool rear taking-up, dry;
(7) Pericarpium Zanthoxyli: removing fruit stem and seed Semen zanthoxyli, to put in pot stir-fry to making sound, oil goes out, take out, cool;
(8) Herba Andrographis: removing impurity, wash quickly is clean, slightly moistens, cutting, dry;
(9) Galla Chinensis: pick clean, knock open, remove wherein impurity;
(10) Plumbum preparatium: be placed in iron pan by pure lead and heat, fries dynamic, utilizes air to make it oxidation, is then placed on pulverize in stone mortar, with water rinse, by thickness powder separately, drifts out fine powder, then through being oxidized 24 hours, being ground into fine powder and sieving and get final product;
(11) Calomelas: get crude drug, removing impurity, is ground into fine powder;
(12) Fructus Evodiae: get crude drug, removing fruit stem, branch and impurity, sieve removes chip;
(13) Squama Manis: get the Squama Manis sheet picking clean, separately size, separately puts sand in pot and makes popular, add Squama Manis sheet, frying to heaving in time golden yellow, taking out, and sieve shakeout, cools;
(14) Calx: preparing quick lime, air slaking are powder;
(15) Mel: get pure Mel, temper with slow fire, filters skimming;
(2) prepare
(1) Carnis Anodonta seu crislaria that the Scolopendra of described consumption and shelling is taken out is placed in watt dries;
(2) Folium Artemisiae Argyi of the Scolopendra of drying and Carnis Anodonta seu crislaria and described weight, Calamina, Cornu Bubali, Colophonium, Pericarpium Zanthoxyli, Herba Andrographis, Galla Chinensis, Plumbum preparatium, Calomelas, Fructus Evodiae, Squama Manis, Calx medicine are pulverized respectively, grind to the powder altogether;
(3) Mel adding described weight in ground described medicine smalls is mixed well, make paste and get final product.
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