CN103191273A - Medicine for treating scabies and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating scabies and a preparation method thereof. The medicine is prepared from hydnocarpus anthelmintica, rheum officinale, babysbreath, radix euphorbiae lantu, borneol, indigo naturalis, calomel, common cnidium fruit, radix sophorae flavescentis, realgar and the like according to a certain weight ratio. The medicine disclosed by the invention has the functions of clearing away heat and toxic materials, sterilizing, relieving pitching, diminishing inflammation, activating blood and dispersing blood stasis, is good in curative effect and high in recovery rate for treatment of the scabies, and fast becomes effective.

Description

A kind of medicine for the treatment of scabies and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of scabies and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Scabies is because the dermatosis that the sarcoptic mite skin infection causes.Sarcoptic mite parasitizes in the skin, excavate to produce mechanical stimulus in " tunnel ", and secretions and Excreta causes allergic reaction, and causes the infected's skin acutely scratchy, and night more so.Primary disease is multiple is born in winter, and the course of disease is different in size, the delayed several months that has.The scabies site of pathological change be more common in skin wrinkle place and thin tender position (as under webs, wrist, the fossa cubitalis, axillary fossa, the breast, positions such as umbilicus week, hypogastric region, external genitalia and burst inboard).The main route of transmission of scabies is respectively: directly contact, as with the patient with bed altogether by, shake hands, embraced ill child etc., the especially close contact of health, easier to be infected; Mediate contact, as contacted the clothes that polluted by sarcoptic mite, towel, footgear, bedding, bath towel etc.The scabies spread speed is fast and infectiousness is very strong, and general sarcoptic mite leaves people's physical ability survival 2～3 days, therefore uses the clothes that patient use, bedding, footgear, medicated cap, pillow covering towel can be by indirect infection, thereby should disease often infection mutually in one family or dormitory.At present, because Western medicine can't effectively effect a radical cure scabies, and recurrence easily, and a lot of side effect are arranged, therefore, there is very big demand in people to the Chinese medicine of effective treatment scabies.

Summary of the invention

The inventor has found the medicine of effective treatment scabies finally, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.

Purpose of the present invention just provides a kind of composition of medicine that can effectively treat scabies.

Another object of the present invention has just provided the preparation method of this composition of medicine.

Medicine of the present invention selects Semen Hydnocarpi, Radix Et Rhizoma Rhei, Caulis et folium pavettae hongkongensis, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Borneolum Syntheticum, Fructus Ulmus preparatium, Indigo Naturalis, Calomelas, Herba Schizonepetae, Cortex Lycii, Semen Arecae, Pericarpium Zanthoxyli, Fructus Cnidii, Resina garciniae, Pulvis Fumi Carbonisatus, Radix Sophorae Flavescentis, Fructus Evodiae, Alumen, Realgar medicine to make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of scabies.Wherein selecting Semen Hydnocarpi for use is because of its nature and flavor suffering, and heat is poisonous, goes into the liver,spleen,kidney warp, and dispeiling pathogenic wind and removing dampness is arranged, and the function of detoxicating and killing parasites is controlled leprosy, scabies, syphilitic skin lesion.Select for use Radix Et Rhizoma Rhei to be because its nature and flavor hardship, cold is gone into stomach, large intestine, liver footpath, the poison of purging heat is arranged, removing mass stagnates, the function of clots absorbing blood is controlled the excess-heat constipation, and delirium is gone mad, the food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, the time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia is spitted blood epistaxis, YANG jaundice, edema, stranguria with turbid discharge, it is red to urinate, the carbuncle and ulcer toxic swelling, furuncle, burn.Selecting Caulis et folium pavettae hongkongensis for use is because of the light little hardship of its nature and flavor, and property is flat, and clearing away heat to improve acuity of vision is arranged, and moves back nebula, and the function of detumescence is controlled corneal leukoma, conjunctival congestion and swelling pain.Select for use the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) to be because its nature and flavor toil is put down, poisonous, it is lunar to start with, and the shaoyin channel edema caused by disorder of QI of holding concurrently is relieved oedema or abdominal distension through diuresis or purgation and eliminated the phlegm, the function of removing mass parasite killing, the swollen abdominal distention of harnessing the river, expectorant, food, malnutrition due to parasitic infestation, trusted subordinate's pain, chronic tracheitis, cough, asthma, tuberculosis such as lymph node, skin, bone, epididymis, scabies, hemorrhoid complicated by anal fistula.Select for use Borneolum Syntheticum to be because its nature and flavor are arduous, the heart, lung meridian are gone in cold, and logical all keys are arranged, the stagnated fire of loosing, and removing nebula makes eye bright, the function of reducing swelling and alleviating pain is controlled the apoplexy locked mouth, calentura coma ， Jing Epilepsy expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, conjunctivitis, enterobiasis.Selecting Fructus Ulmus preparatium for use is that temperature is gone into spleen, stomach warp, and parasite killing is arranged because of its nature and flavor toil, and the function of removing food stagnancy is controlled abdominal pain due to worm stagnation, children's's infantile malnutrition with diarrhea, cold-dysentery, scabies, malignant boil.Select for use Indigo Naturalis to be because its nature and flavor are salty, cold, go into liver, lung, stomach warp, heat clearing away is arranged, removing heat from blood, the function of detoxifcation is controlled the epidemic febrile disease intenseness of heat, and macule is spitted blood, is spat blood, Xiao Jing Epilepsy, skin ulcer is swollen, erysipelas, snake bite and insect sting.Select for use Calomelas to be because its nature and flavor suffering is cold, poisonous, return liver, kidney, large intestine channel, counteracting toxic substances is arranged, putrefaction removing, the function of parasite killing is used for skin infection outward and festers syphilis, rosacea, neurodermatitis; The removing food stagnancy that eliminates the phlegm for oral administration, the relieving constipation of relieving oedema or abdominal distension through diuresis or purgation, it is stagnant to be used for sputum, and edema expands, difficulty in urination and defecation.Selecting Herba Schizonepetae for use is that temperature is gone into lung, Liver Channel, delivers because of its nature and flavor suffering, dispel the wind, and the function for the treatment of blood disorders, the parch to black hemostasis, the heating that cures cold, headache, laryngopharynx swelling and pain, the apoplexy locked mouth is spitted blood, and epistaxis is had blood in stool, metrorrhagia, puerperal blood faints, carbuncle, skin ulcer scabies, scrofula.Select for use Cortex Lycii to be because its nature and flavor are sweet, cold, go into lung, liver, kidney channel, heat clearing away is arranged, the function of removing heat from blood is controlled asthenia hectic fever night sweat, and the lung-heat cough with asthma is spitted blood, epistaxis, stranguria with blood is quenched one's thirst, hypertension, carbuncle, malignant boil.Selecting Semen Arecae for use is that temperature is gone into spleen, stomach, large intestine channel, and parasite killing is arranged because of its nature and flavor toil, removing mass, and the therapeutic method to keep the adverse QI flowing downwards, the function of row water is controlled malnutrition due to parasitic infestation, dyspepsia, and abdominal distention is heavy behind the dysentery, malaria, edema, beriberi, accumulation of phlegm in the hypochondrium ， Disorder knot.Selecting Pericarpium Zanthoxyli for use is because of its nature and flavor suffering, and temperature is poisonous, goes into spleen, lung, kidney channel, warming spleen and stomach for dispelling cold is arranged, dehumidifying, pain relieving, parasite killing, separate fish raw meat poison, control food stagnation and stop drink, trusted subordinate's cold type of pain, vomiting, oh, and cough with dyspnea, anemofrigid-damp arthralgia is had loose bowels, dysentery, colic, toothache, ascariasis, enterobiasis, pudendal pruritus, skin ulcer scabies.Select for use Fructus Cnidii to be because its nature and flavor are arduous, temperature is gone into kidney, spleen channel, and warming the kidney to activate YANG is arranged, dispel the wind, and dampness, the function of parasite killing is controlled impotence in male, the scrotum pruritus due to damp pathogen, woman's leukorrhagia pudendal pruritus, cold uterus is infertile, rheumatic arthralgia, scabies eczema.Select for use Resina garciniae to be because its nature and flavor are sour and astringent, poisonous, detumescence is arranged, removing toxic substances, hemostasis, the function of parasite killing is controlled swollen ulcer drug, stubborn dermatitis malignant boil, bleeding due to trauma, ulcerative gingivitis decayed tooth, burn.Select Pulvis Fumi Carbonisatus for use, its nature and flavor suffering, temperature.Go into liver, lung, stomach warp.Hemostasis, removing food stagnancy.Control haematemesis, epistaxis is had blood in stool, metrorrhagia, leukorrhagia, dysentery, food stagnation, all skin ulcers of throat dispute.Select for use Radix Sophorae Flavescentis to be because its nature and flavor hardship is cold, go into liver, kidney, large intestine, small intestine meridian, heat clearing away is arranged, dampness, the function of parasite killing is controlled toxic-heat and blood stasis, discharging fresh blood stool, jaundice, leucorrhea with red and white discharge, infantile pneumonia, infantile malnutrition, acute tonsillitis, anal fistula, proctoptosis, skin pruritus, erosion of vulva pruritus due to damp pathogen, scrofula is scalded.Select for use Fructus Evodiae to be because its nature and flavor are arduous, temperature, poisonous, go into liver, stomach warp, warming middle-JIAO is arranged, pain relieving is regulated the flow of vital energy, the function of dampness, the contrary acid regurgitation of stopping vomiting, headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.Select for use Alumen to be because its nature and flavor are sour and astringent, cold, poisonous, go into lung, spleen, stomach, large intestine channel, expectorant is arranged, dampness, antidiarrheal, detoxifcation, the function of parasite killing, the Zhi epilepsy, sore throat, sputum is stopped up very, hepatitis, jaundice, general edema with yellowish skin, stomach, duodenal ulcer, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies, water, fire, insect bite.Select for use Realgar to be because its nature and flavor are arduous, temperature, poisonous, dampness is arranged, dispel the wind, parasite killing, the function of detoxifcation is controlled scabies, tinea alba, carbuncle, acute gangrenous stomatitis, herpes zoster, tetanus, snakeworm sting, bromhidrosis, ecthyma, asthma, sore throat ， Jing Epilepsy, hemorrhoid complicated by anal fistula.

The specific embodiment

The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has better curative effect in the following weight scope

Semen Hydnocarpi 8-15 gram Radix Et Rhizoma Rhei 15-25 gram Caulis et folium pavettae hongkongensiss 10-15 grams

The Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 10-20 gram Borneolum Syntheticums 1-4 gram Fructus Ulmus preparatium 15-21 grams

Indigo Naturalis 5-9 gram Calomelass 4-10 gram Herba Schizonepetae 10-20 grams

Cortex Lycii 5-11 gram Semen Arecaes 5-15 gram Pericarpium Zanthoxylies 5-11 grams

Fructus Cnidii 5-15 gram Resina garciniaes 1-4 gram Pulvis Fumi Carbonisatuss 5-11 grams

Radix Sophorae Flavescentis 10-15 gram Fructus Evodiaes 5-15 gram Alumens 5-15 grams

Realgar 5-11 gram vaseline 50-80 grams

Preferable amount is

Semen Hydnocarpi 10 gram Radix Et Rhizoma Rhei 15 gram Caulis et folium pavettae hongkongensiss 12 grams

The Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 15 gram Borneolum Syntheticums 2 gram Fructus Ulmus preparatium 18 grams

Indigo Naturalis 6 gram Calomelass 5 gram Herba Schizonepetae 15 grams

Cortex Lycii 8 gram Semen Arecaes 10 gram Pericarpium Zanthoxylies 8 grams

Fructus Cnidii 10 gram Resina garciniaes 2 gram Pulvis Fumi Carbonisatuss 8 grams

Radix Sophorae Flavescentis 12 gram Fructus Evodiaes 10 gram Alumens 10 grams

Realgar 8 gram vaseline 60 grams

The preparation method of medicine of the present invention is as follows

One, gets the raw materials ready

1, Semen Hydnocarpi: choose clean impurity, sieve dedust soil, the time spent smashs to pieces, or removes kind of a skin, gets clean core;

2, Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;

3, Caulis et folium pavettae hongkongensis: get crude drug, remove impurity, dry;

4, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae): wash, run through, section is dried;

5, Borneolum Syntheticum: original is used as medicine;

6, Fructus Ulmus preparatium: in adopting the real core of getting the lunar calendar 4-5 month, with seed 60%, Radix Patriniae Scabrae 20%, tame Cortex ulmi pumilae 10%, humus flava usta 10% is mixed and made into flat square, places to dry under the daylight;

7, Indigo Naturalis: choose decontamination, cross sieve;

8, Calomelas: get crude drug, remove impurity, grind into fine powder;

9, Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries;

10, Cortex Lycii: choose decontamination and core, slightly wash, cutting is dried;

11, Semen Arecae: choose decontamination, soak with clear water, change water by the temperature situation, till soaking, pick up, section is dried;

12, Pericarpium Zanthoxyli: remove fruit stem and seed, put pot interior stir-fry to make sound, oil goes out, and takes out, cool;

13, Fructus Cnidii: choose decontamination, sieve removes silt particle, cleans, and dries;

14, Resina garciniae: Resina garciniae is added in the bright Sanguis Naemorhedi, put in the copper pot, add water with boiling 5-6 hour, go Sanguis Naemorhedi to dry, 1 jin of every Resina garciniae is with bright Sanguis Naemorhedi half a year;

15, Pulvis Fumi Carbonisatus: the grey black with in chimney or the chimney, scrape gently, sieve decontamination with dusting cover;

16, Radix Sophorae Flavescentis: choose clean impurity, remove residual stem, clean earth, be soaked in water, pull out, run through, section is dried;

17, Fructus Evodiae: get crude drug, remove fruit stem, branch and impurity, sieve removes chip;

18, Alumen: get the Alumen of choosing clean, put in the marmite heating and dissolve and forge to dried-up, take out, cut piece;

19, Realgar: grind into impalpable powder, or water flies, dry.

Two, preparation

Semen Hydnocarpi, Radix Et Rhizoma Rhei, Caulis et folium pavettae hongkongensis, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Borneolum Syntheticum, Fructus Ulmus preparatium, Indigo Naturalis, Calomelas, Herba Schizonepetae, Cortex Lycii, Semen Arecae, Pericarpium Zanthoxyli, Fructus Cnidii, Resina garciniae, Pulvis Fumi Carbonisatus, Radix Sophorae Flavescentis, Fructus Evodiae, Alumen, the Realgar medicine of described weight are ground into powder, add 60 gram vaseline and stir into pasty state and get final product.

Medicine of the present invention has the effect of heat-clearing and toxic substances removing, sterilizing and itch-relieving, blood circulation promoting and blood stasis dispelling, and treatment scabies instant effect, short treating period do not recur.

Below further set forth the beneficial effect of medicine of the present invention by testing example, these tests comprise that the animal toxicity test of medicine of the present invention reports and clinical observation material.

The animal toxicity test report of [test example 1] medicine of the present invention

Select 10 of new zealand rabbits for use, 10 rabbit abdominal part rabbit hairs are pulled out light, every rabbit is with medicine 10 grams of the present invention, smears the rabbit abdomen place after the depilation, with the gauze parcel, is used in conjunction 7 days every day twice, checks that the rabbit abdomen is normal, and 10 rabbit all do not have any untoward reaction.

By the test to new zealand rabbit, the result shows, uses Drug therapy of the present invention without any side effects by normal amount.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 150 examples for medical treatment, 20-30 year 35 examples wherein, 30-40 year 95 examples, 20 examples more than 40 years old, patients with mild 100 examples wherein, severe patient's 50 examples.

2, diagnostic criteria

Mild: main performance is pruritus, red little pimple, papulovesicle, phlysis, tuberosity and incrustation.

Severe symptom: have sarcoptic mite to pierce horny layer on the skin, and the thin-line-shaped tunnel of formation canescence or light/dark balance bending is about 2-3mm, even 15mm, little pimple or the chickenpox of end has light red, scarlet or normal color of the leather can cause the secondary infection of skin because scratching.

3, Therapeutic Method

Select above-mentioned medicament for use, use to the patient, clean the affected part with clear water earlier, be applied in the affected part with medicine again, patients with mild every day early, evening each once, 7 days is a course for the treatment of, uses 2 courses for the treatment of continuously.Severe patient is early, middle and late respectively once every day, and 7 days is a course for the treatment of, uses 3 courses for the treatment of continuously.

4, efficacy assessment standard

Produce effects: transference cure, body constitution recover normal, observe 1 year no recidivist;

Take a turn for the better: symptom is clearly better, and symptom fades away;

Invalid: as not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, with Drug therapy scabies patient 150 examples of the present invention, patients with mild 100 examples wherein, produce effects 95 examples as a result, obvious effective rate is 95%, 4 examples that take a turn for the better, improvement rate is 4%, invalid 1 example, total effective rate is 99%.Severe patient's 50 examples, produce effects 46 examples as a result, obvious effective rate is 92%, 3 examples that take a turn for the better, improvement rate is 6%, invalid 1 example, total effective rate is 98%.

Claims (3)

1. medicine for the treatment of scabies, it is characterized in that: it is to be made by the crude drug in the following weight range:

Semen Hydnocarpi 8-15 gram Radix Et Rhizoma Rhei 15-25 gram Caulis et folium pavettae hongkongensiss 10-15 grams

The Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 10-20 gram Borneolum Syntheticums 1-4 gram Fructus Ulmus preparatium 15-21 grams

Indigo Naturalis 5-9 gram Calomelass 4-10 gram Herba Schizonepetae 10-20 grams

Cortex Lycii 5-11 gram Semen Arecaes 5-15 gram Pericarpium Zanthoxylies 5-11 grams

Fructus Cnidii 5-15 gram Resina garciniaes 1-4 gram Pulvis Fumi Carbonisatuss 5-11 grams

Radix Sophorae Flavescentis 10-15 gram Fructus Evodiaes 5-15 gram Alumens 5-15 grams

Realgar 5-11 gram vaseline 50-80 grams.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Semen Hydnocarpi 10 gram Radix Et Rhizoma Rhei 15 gram Caulis et folium pavettae hongkongensiss 12 grams

The Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 15 gram Borneolum Syntheticums 2 gram Fructus Ulmus preparatium 18 grams

Indigo Naturalis 6 gram Calomelass 5 gram Herba Schizonepetae 15 grams

Cortex Lycii 8 gram Semen Arecaes 10 gram Pericarpium Zanthoxylies 8 grams

Fructus Cnidii 10 gram Resina garciniaes 2 gram Pulvis Fumi Carbonisatuss 8 grams

Radix Sophorae Flavescentis 12 gram Fructus Evodiaes 10 gram Alumens 10 grams

Realgar 8 gram vaseline 60 grams.

3. according to the preparation method of claim 1 or 2 described medicines, it comprises the following steps:

(1) gets the raw materials ready

(1) Semen Hydnocarpi: choose clean impurity, sieve dedust soil, the time spent smashs to pieces, or removes kind of a skin, gets clean core;

(2) Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;

(3) Caulis et folium pavettae hongkongensis: get crude drug, remove impurity, dry;

(4) Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae): wash, run through, section is dried;

(5) Borneolum Syntheticum: original is used as medicine;

(6) Fructus Ulmus preparatium: in adopting the real core of getting the lunar calendar 4-5 month, with seed 60%, Radix Patriniae Scabrae 20%, tame Cortex ulmi pumilae 10%, humus flava usta 10% is mixed and made into flat square, places to dry under the daylight;

(7) Indigo Naturalis: choose decontamination, cross sieve;

(8) Calomelas: get crude drug, remove impurity, grind into fine powder;

(9) Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries;

(10) Cortex Lycii: choose decontamination and core, slightly wash, cutting is dried;

(11) Semen Arecae: choose decontamination, soak with clear water, change water by the temperature situation, till soaking, pick up, section is dried;

(12) Pericarpium Zanthoxyli: remove fruit stem and seed, put pot interior stir-fry to make sound, oil goes out, and takes out, cool;

(13) Fructus Cnidii: choose decontamination, sieve removes silt particle, cleans, and dries;

(14) Resina garciniae: Resina garciniae is added in the bright Sanguis Naemorhedi, put in the copper pot, add water with boiling 5-6 hour, go Sanguis Naemorhedi to dry, 1 jin of every Resina garciniae is with bright Sanguis Naemorhedi half a year;

(15) Pulvis Fumi Carbonisatus: the grey black with in chimney or the chimney, scrape gently, sieve decontamination with dusting cover;

(16) Radix Sophorae Flavescentis: choose clean impurity, remove residual stem, clean earth, be soaked in water, pull out, run through, section is dried;

(17) Fructus Evodiae: get crude drug, remove fruit stem, branch and impurity, sieve removes chip;

(18) Alumen: get the Alumen of choosing clean, put in the marmite heating and dissolve and forge to dried-up, take out, cut piece;

(19) Realgar: grind into impalpable powder, or water flies, dry;

(2) preparation

Semen Hydnocarpi, Radix Et Rhizoma Rhei, Caulis et folium pavettae hongkongensis, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Borneolum Syntheticum, Fructus Ulmus preparatium, Indigo Naturalis, Calomelas, Herba Schizonepetae, Cortex Lycii, Semen Arecae, Pericarpium Zanthoxyli, Fructus Cnidii, Resina garciniae, Pulvis Fumi Carbonisatus, Radix Sophorae Flavescentis, Fructus Evodiae, Alumen, the Realgar medicine of described weight are ground into powder, add 60 gram vaseline and stir into pasty state and get final product.