CN100540044C - A kind of psoriasic Chinese medicine for oral administration and preparation method thereof that is used for the treatment of - Google Patents

Abstract

The invention discloses the psoriasic Chinese medicine for oral administration of a kind of treatment, it be with Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Imperatae, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Herba Violae, Flos Chrysanthemi, Herba Taraxaci, rhizoma sparganic, Rhizoma Curcumae, Cortex Moutan, Fructus Gardeniae, pollen, Fructus Mume, Radix Clematidis, Radix Arnebiae (Radix Lithospermi), Radix Isatidis, Folium Isatidis, Herba Portulacae, Radix Curcumae, Radix Salviae Miltiorrhizae, Gypsum Fibrosum, Fructus Arctii, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, the Rhizoma Pinelliae, the Radix Linderae, Pericarpium Citri Reticulatae, Poria, Radix Asparagi, Fructus Atriplicis Sibiricae, Bombyx Batryticatus, Radix Ophiopogonis be crude drug, and the preparation method of above-mentioned Chinese medicine for oral administration water preparation is further disclosed.Clinical medicine practise proves that this Chinese medicine for oral administration has specially good effect to the treatment psoriasis, and more the back is difficult for recurrence.

Description

A kind of psoriasic Chinese medicine for oral administration and preparation method thereof that is used for the treatment of

Technical field

The present invention relates to a kind of psoriasic Chinese medicine for oral administration that is used for the treatment of, the invention still further relates to the preparation method of this Chinese medicine for oral administration, belong to tcm field.

Background technology

Psoriasis claims psoriasis again, is a kind of common chronic dermatosis.The physiopathologic important feature of this disease is the normal showed increased that the basal layer epithelial cells enters the hypertrophy pond, and cell proliferation quickens, the mitoschisis cycle foreshortened to 37.5 hours from normal 311 hours, epidermal transit time also foreshortened to 3～4 days from 28～56 days, because what epithelial cells was too fast passes through epidermis, make it have little time full maturity, so cause on the histology, occurring parakeratosis easily, the result that granular layer disappears.From the skin lesion feature of this disease, originally it the erythema pimple occurs, the silvery white from level to level squama of surface coverage, and xerosis cutis, desquamation incrustation, the skin symptom that has joins together, shape such as map, the pruritus that has, the flowing water of suppurating.According to the degree difference of skin lesion, this disease can be divided into four types: psoriasis vulgaris, and erythrodermic psoriasis, psoriasis arthropathica and psoriasis pustulosa, the traditional Chinese medical science then is divided into three types of blood-heat types, blood-dryness type, blood stasis type.

Studies show that for many years this disease has obvious seasonal, most of patients state of an illness spring, winter increase the weight of, and alleviate summer.In addition, this disease also has certain disease locus selectivity, is mainly in the exposed position of human body, as positions such as head, extremity, shirtfront, back.Though this disease is threat to life not, through obstinate, the delay recurrence increases the weight of year by year, and desquamation blood stasis, pruritus due to dryness bring great misery for patient body and physical and mental health unbearably, badly influence quality of life; Especially young boys and girls, the flesh table is ashamed of exposing, and directly influences attractive in appearancely, is learnt, works, makes friends and bring very big negative effect.At present, the sickness rate of this disease is and rises significantly and shift to an earlier date trend.

Probe into from its pathogenic factor, there are a lot of predisposing factors in it, it is generally acknowledged that its inducement is inherited genetic factors and the coefficient result of environmental factors.Probe into from the inherent function of human body, the multiple inducement of this disease is immunologic function disorder, dysbolismus and dysendocrisiasis, and above-mentioned obstacle has directly caused epidermal tissue to learn the disorder of seriation and keratinization.

The traditional Chinese medical science thinks that psoriasic essence is part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness.Defending for the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is to say that defending aerial root comes from the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, and the kidney of lower warmer YANG deficiency then a little less than the deficiency of defensive qi, is defended outer function mistake department, in case the evil poison of impression, evil poison is tied in skin, and qi and blood circulation is obstructed, failure of skin and muscle to be nourished psoriasis.Also bright instruction psoriasis belongs to the carbuncle of yin nature disease of deficiency and coldness in " Ling Shu Miraculous Pivot or Divine Axis carbuncle ".Treating psoriasis in view of the above works as based on temperature compensation.But in the antipsoriatics thing, the Western medicine majority is based on hormone medicine in the prior art, and it can take stopgap measures but can't effect a permanent cure, and repeatedly recurrence is repeatedly used, and can cause the influence to other major organs of human body for a long time.Than above-mentioned Western medicine, have no side effect though be used for the treatment of psoriasic Western medicine, but its general course of treatment is very long, it is very slow to take effect.

Summary of the invention

To be solved by this invention is that Western medicine has toxic and side effects in the existing antipsoriatics thing, cure the symptoms, not the disease, though Chinese medicine has no side effect its course of treatment the very long and slow problem that takes effect, and then provide a kind of psoriasic specially good effect Chinese medicine for oral administration that is used for the treatment of.

The present invention realizes that by following solution the weight portion of the crude drug of the psoriasic Chinese medicine for oral administration of described treatment is:

Radix Saposhnikoviae 5～15, Herba Schizonepetae 5～15, Rhizoma Imperatae 10～20, Flos Lonicerae 10～20, Radix Scutellariae 5～15, Fructus Forsythiae 10～20, Herba Violae 10～20, Flos Chrysanthemi 5～15, Herba Taraxaci 20～40, rhizoma sparganic 2～9, Rhizoma Curcumae 2～9, Cortex Moutan 5～15, Fructus Gardeniae 5～15, pollen 10～20, Fructus Mume 5～15, Radix Clematidis 10～20, Radix Arnebiae (Radix Lithospermi) 10～20, Radix Isatidis 10～20, Folium Isatidis 10～20, Herba Portulacae 5～15, Radix Curcumae 5～15, Radix Salviae Miltiorrhizae 10～20, Gypsum Fibrosum 20～40, Fructus Arctii 10～20, the Radix Paeoniae Alba 5～15, the Rhizoma Anemarrhenae 5～15, the Rhizoma Pinelliae 5～15, the Radix Linderae 5～15, Pericarpium Citri Reticulatae 5～15, Poria 5～15, Radix Asparagi 5～15, Fructus Atriplicis Sibiricae 10～20, Bombyx Batryticatus 5～15, Radix Ophiopogonis 5～15.

Wherein, the weight portion of preferred described Chinese medicine for oral administration crude drug is: Radix Saposhnikoviae 8～12, Herba Schizonepetae 8～12, Rhizoma Imperatae 12～18, Flos Lonicerae 12～18, Radix Scutellariae 8～12, Fructus Forsythiae 12～18, Herba Violae 12～18, Flos Chrysanthemi 8～12, Herba Taraxaci 25～35, rhizoma sparganic 5～7, Rhizoma Curcumae 5～7, Cortex Moutan 8～12, Fructus Gardeniae 8～12, pollen 12～18, Fructus Mume 8～12, CHENGLINGXIAN 12～18, Radix Arnebiae (Radix Lithospermi) 12～18, Radix Isatidis 12～18, Folium Isatidis 12～18, Herba Portulacae 8～12, Radix Curcumae 8～12, Radix Salviae Miltiorrhizae 12～18, Gypsum Fibrosum 25～35, Fructus Arctii 12～18, the Radix Paeoniae Alba 8～12, the Rhizoma Anemarrhenae 8～12, the Rhizoma Pinelliae 8～12, the Radix Linderae 8～12, Pericarpium Citri Reticulatae 8～12, Poria 8～12, Radix Asparagi 8～12, Fructus Atriplicis Sibiricae 12～18, Bombyx Batryticatus 8～12, Radix Ophiopogonis 8～12.

Optimum weight part of described Chinese medicine for oral administration crude drug is: Radix Saposhnikoviae 10, Herba Schizonepetae 10, Rhizoma Imperatae 15, Flos Lonicerae 15, Radix Scutellariae 10, Fructus Forsythiae 15, Herba Violae 15, Flos Chrysanthemi 10, Herba Taraxaci 30, rhizoma sparganic 6, Rhizoma Curcumae 6, Cortex Moutan 10, Fructus Gardeniae 10, pollen 15, Fructus Mume 10, Radix Clematidis 15, Radix Arnebiae (Radix Lithospermi) 15, Radix Isatidis 15, Folium Isatidis 15, Herba Portulacae 10, Radix Curcumae 10, Radix Salviae Miltiorrhizae 15, Gypsum Fibrosum 30, Fructus Arctii 15, the Radix Paeoniae Alba 10, the Rhizoma Anemarrhenae 10, the Rhizoma Pinelliae 10, the Radix Linderae 10, Pericarpium Citri Reticulatae 10, Poria 10, Radix Asparagi 10, Fructus Atriplicis Sibiricae 15, Bombyx Batryticatus 10, Radix Ophiopogonis 10.

The dosage form of above-mentioned Chinese medicine for oral administration can be water preparation, powder or honeyed pill.

The present invention also further discloses the water preparation preparation method of the psoriasic Chinese medicine for oral administration of above-mentioned treatment, and it comprises the steps: (1) selection quality raw materials medicine medical material, and above-mentioned medical material is placed in the dehydrator, in 35～50 ℃ above-mentioned medical material is dried; (2) take by weighing the crude drug of the drying of specified weight part, the crude drug except that Gypsum Fibrosum that takes by weighing is mixed; (3) the unmixing Gypsum Fibrosum that takes by weighing is put into water and carried out fried 10～35 minutes, will put into fried 10～35 minutes through the mixed crude drug of step (2) afterwards; (4) it is fried to carry out secondary through the medicinal residues that step (3) after-filtration obtains, and the fried time is 10～35 minutes; (5) water preparation that step (3) and step (4) are obtained mixes and gets final product.

Wherein, can before described step (2) is mixed the crude drug after the drying, described crude drug be pulverized, and cross 200 mesh sieves.

The traditional Chinese medical science thinks that psoriasis is by due to the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness, so treatment should be based on temperature compensation Liver and kidney, heat-clearing and toxic substances removing.Solution of the present invention promptly is based on above-mentioned to pathogenetic understanding of psoriasis and Therapeutic Principle, and with reference to the modern pharmacological research achievement, the prescription of the heat-clearing and toxic substances removing that obtains, blood circulation promoting and blood stasis dispelling, temperature compensation Liver and kidney, adjusting immune function.By the theory of Chinese medical science prescription, this Chinese medicine for oral administration has embodied whole control key of distinguishing, brought into play treating both the principal and the secondary aspects of a disease at the same time, the effect of the Re Zhinei that dispels, also strengthened simultaneously immune regulatory function in the human body, treat psoriasic effect from truly having played " supporting vital QI to relieve the primary cause of disease ".

This prescription not only is conceived to skin to the treatment of this disease, also notes the adjusting of whole interior function, emphasized heat clearing away set upright be only basic.Set upright and to transfer tonifying liver, kidney; Heat clearing away should blood circulation promoting and blood stasis dispelling, let out turbid detoxifcation.So in the prescription, it is cold in nature to get Flos Lonicerae, bitter in the mouth is gone into lung, stomach warp, has the effect of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; The Radix Scutellariae bitter in the mouth, cold in nature, go into the heart, lung, gallbladder, large intestine channel, but the removing the relative excess fire, except that damp and hot, hemostasis; Rhizoma Imperatae, cold and cool and flavor is very sweet, the heat of the branch that can purify the blood, and not hindering in dry, not sticky again, so removing heat from blood and do not consider its long-pending stasis of blood; The heart, liver, gallbladder meridian are gone in Fructus Forsythiae nature and flavor hardship, cold, have heat clearing away, detoxifcation, eliminating stagnation, the effect of detumescence; The Flos Chrysanthemi sweet-bitter flavor, cool in nature, go into lung, Liver Channel, have dispelling wind, heat clearing away makes eye bright, the effect of detoxifcation; Herba Taraxaci has the effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Cortex Moutan acrid in the mouth hardship, cold in nature has the effect of promoting blood circulation and cooling blood, energy dissipating blood stasis blood, subduing inflammation; Fructus Gardeniae bitter in the mouth, cold in nature, GUIXIN, liver, lung, stomach warp have the effect of pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain; The pollen property of medicine is gentle, and zest is little, is suitable for the control to dermatopathy; The Fructus Mume sour in the mouth, warm in nature, go into liver, spleen, lung, large intestine channel, can restrain and promote the production of body fluid; The Radix Arnebiae (Radix Lithospermi) bitter in the mouth, cold in nature, go into percardium, Liver Channel, have removing heat from blood, invigorate blood circulation heat clearing away, the effect of detoxifcation.The Radix Isatidis bitter in the mouth, cold in nature, go into liver, stomach blood system, have heat clearing away, detoxifcation, the effect of removing heat from blood; The Folium Isatidis bitter in the mouth, cold in nature, go into liver, the heart, stomach warp, have heat clearing away, detoxifcation, removing heat from blood, the effect of hemostasis; The Herba Portulacae sour in the mouth, cold in nature, go into large intestine, liver, spleen channel, but heat-clearing and toxic substances removing, the blood detumescence of loosing; Gypsum Fibrosum is hot sweet cold in nature, goes into lung meridian, can clearing away heat-fire, eliminating heat from the lung and rash, minute excess-heat that can lose heart clearly again is with expelling pathogenic factors from muscles, go into stomach through rushing down stomach-fire clearly dissipating rashes; Fructus Arctii acrid in the mouth, hardship, cool in nature, go into lung, stomach warp, have dispelling wind and heat pathogens, lung qi dispersing rash, the effect of subduing swelling and detoxicating; The acid of Radix Paeoniae Alba bitter in the mouth, cool in nature, go into liver, spleen channel, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received the effect of antiperspirant; Rhizoma Anemarrhenae bitter in the mouth, sweet, cold, can return lung, stomach, kidney channel, have clearing away heat-fire, the effect of promoting the production of body fluid and moisturizing; Radix Asparagi is cold in nature, sweet in the mouth, hardship, but lung moistening clears away heart-fire; Radix Ophiopogonis cold nature, sweet in the mouth, little hardship, GUIXIN, lung, stomach warp have the effect that lung moistening clears away heart-fire; The above-mentioned raw materials medicine is auxilliary mutually, regards as monarch drug, and synergism is brought into play the effect of its heat clearing away, removing heat from blood, detoxifcation.

In addition, be ministerial drug with Radix Saposhnikoviae, Herba Schizonepetae, rhizoma sparganic, Rhizoma Curcumae, Radix Curcumae, Radix Salviae Miltiorrhizae, Fructus Atriplicis Sibiricae, Bombyx Batryticatus in the prescription.It gets the Radix Saposhnikoviae acrid-sweet flavor, and is warm in nature, goes into bladder, lung, spleen channel, and tool dispels the wind, the effect of pain relieving; Herba Schizonepetae is warm in nature, and acrid in the mouth is gone into lung, Liver Channel, can deliver, and dispels the wind treating blood disorders; Rhizoma sparganic nature and flavor toil, flat is gone into liver, but removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving; Rhizoma Curcumae bitter in the mouth suffering, warm in nature, go into liver, spleen channel, have the removing blood stasis circulation of qi promoting, the effect of removing food stagnancy pain relieving; The Radix Curcumae nature and flavor are arduous, cool, go into the heart, lung, Liver Channel, but promoting QI circulation for relieving depression, the removing heat from blood removing blood stasis with potent drugs; Get Radix Salviae Miltiorrhizae nature and flavor hardship, tepor, go into the heart, Liver Channel, have the effect of blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, evacuation of pus, pain relieving; Fructus Atriplicis Sibiricae has another name called Fructus Tribuli, and the bitter in the mouth suffering is warm in nature, goes into liver, lung meridian, has diffusing wind, makes eye bright the therapeutic method to keep the adverse QI flowing downwards, the effect of promoting the circulation of blood; Bombyx Batryticatus distinguishes the flavor of, suffering, and property is flat, returns liver, lung, stomach warp, but expelling wind for relieving convulsion, dissipating phlegm and resolving masses; The collaborative performance of above-mentioned raw materials medicine blood circulation promoting and blood stasis dispelling, the effect of dispeling the wind.

Also get Rhizoma Pinelliae acrid in the mouth in the prescription, warm in nature, go into spleen, stomach warp, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the effect of dissolving lump and resolving mass; Radix Linderae acrid in the mouth, warm in nature, go into spleen, lung, kidney, urinary bladder channel, can be pleasant, dissipating depression of QI, cold expelling, pain relieving; Pericarpium Citri Reticulatae is warm in nature, and bitter in the mouth, suffering have the effect of regulating qi-flowing for strengthening spleen; The Poria slightly sweet flavor, property is flat, goes into the heart, spleen, lung meridian, its eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming; Get the characteristic of the spleen benefiting and stimulating the appetite of above-mentioned effect, nominal is an adjuvant drug.

Except that the above-mentioned raw materials medicine, in all the other crude drug in the prescription, get the Herba Violae bitter in the mouth, cold in nature, go into the heart, Liver Channel, have clearing away heat-damp and promoting diuresis, the effect of removing toxic substances and promoting subsidence of swelling; Radix Clematidis acrid in the mouth, one-tenth, warm in nature, go into lung, kidney two warps, have wind-damp dispelling, the meridian dredging, expectorant saliva, the effect of the hypochondriac lump of loosing.The two synergism has the effect of tying-in, is called messenger drug.

Synergism by monarch, minister in the above-mentioned raw materials medicine, between helping, making it, can be so that patient's temperature compensation Liver and kidney, thereby regulate and the enhancing human body immunity ability, and interior-heat is separated from table with sweating, let out turbid heat-clearing and toxic substances removing thereby reach, QI and blood is unobstructed, and meridians are unimpeded, reduce epidermal hyperplasia speed, thereby improve the patient's condition.

The present invention has following advantage:

1. to select natural plants, biological Chinese medicine for use be raw material in the present invention, adopts the comprehensive function of the Chinese medicine of respectively distinguishing the flavor of to treat psoriasis, without any side effects, and can not cause damage to skin.

2. the psoriasic Chinese medicine for oral administration of this treatment pays attention to regulating inside of human body function, particularly function of immune system simultaneously based on blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, temperature compensation Liver and kidney.In heat-clearing and toxic substances removing, pay attention to treating both the principal and secondary aspects of a disease, it is unimpeded that the body QI and blood is in harmonious proportion.

3. by clinical observation, each parapsoriasis is all had effect preferably, and more the back is difficult for recurrence, short treating period.

The specific embodiment

Embodiment 1

Select quality raw materials medicine Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Imperatae, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Herba Violae, Flos Chrysanthemi, Herba Taraxaci, rhizoma sparganic, Rhizoma Curcumae, Cortex Moutan, Fructus Gardeniae, pollen, Fructus Mume, Radix Clematidis, Radix Arnebiae (Radix Lithospermi), Radix Isatidis, Folium Isatidis, Herba Portulacae, Radix Curcumae, Radix Salviae Miltiorrhizae, Gypsum Fibrosum, Fructus Arctii, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, the Rhizoma Pinelliae, the Radix Linderae, Pericarpium Citri Reticulatae, Poria, Radix Asparagi, Fructus Atriplicis Sibiricae, Bombyx Batryticatus, Radix Ophiopogonis, above-mentioned medical material is placed in the dehydrator, above-mentioned medical material is dried 1h in 35 ℃; Take by weighing Radix Saposhnikoviae 5 grams after the above-mentioned drying, Herba Schizonepetae 5 grams, Rhizoma Imperatae 10 grams, Flos Lonicerae 10 grams, Radix Scutellariae 5 grams, Fructus Forsythiae 10 grams, Herba Violae 10 grams, Flos Chrysanthemi 5 grams, Herba Taraxaci 20 grams, rhizoma sparganic 2 grams, Rhizoma Curcumae 2 grams, Cortex Moutan 5 grams, Fructus Gardeniae 5 grams, pollen 10 grams, Fructus Mume 5 grams, Radix Clematidis 10 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, Radix Isatidis 10 grams, Folium Isatidis 10 grams, Herba Portulacae 5 grams, Radix Curcumae 5 grams, Radix Salviae Miltiorrhizae 10 grams, Gypsum Fibrosum 20 grams, Fructus Arctii 10 grams, the Radix Paeoniae Alba 5 grams, the Rhizoma Anemarrhenae 5 grams, the Rhizoma Pinelliae 5 grams, the Radix Linderae 5 grams, Pericarpium Citri Reticulatae 5 grams, Poria 5 grams, Radix Asparagi 5 grams, Fructus Atriplicis Sibiricae 10 grams, Bombyx Batryticatus 5 grams, restrain Radix Ophiopogonis 5.Afterwards, above-mentioned all the other crude drug except that Gypsum Fibrosum that take by weighing are mixed.

The unmixing Gypsum Fibrosum that takes by weighing 20 grams were put into water fried 10 minutes; Afterwards above-mentioned mixed crude drug is put into fried again 10 minutes; Above-mentioned Chinese medicine after fried is filtered, and it is fried that the medicinal residues that obtain are carried out secondary, fried 10 minutes; Above-mentioned twice fried water preparation mixing that obtains can be obtained the psoriasic Chinese medicine for oral administration water preparation of treatment of the present invention.

Embodiment 2

Select quality raw materials medicine Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Imperatae, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Herba Violae, Flos Chrysanthemi, Herba Taraxaci, rhizoma sparganic, Rhizoma Curcumae, Cortex Moutan, Fructus Gardeniae, pollen, Fructus Mume, Radix Clematidis, Radix Arnebiae (Radix Lithospermi), Radix Isatidis, Folium Isatidis, Herba Portulacae, Radix Curcumae, Radix Salviae Miltiorrhizae, Gypsum Fibrosum, Fructus Arctii, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, the Rhizoma Pinelliae, the Radix Linderae, Pericarpium Citri Reticulatae, Poria, Radix Asparagi, Fructus Atriplicis Sibiricae, Bombyx Batryticatus, Radix Ophiopogonis, above-mentioned medical material is placed in the dehydrator, above-mentioned medical material is dried 0.5h in 40 ℃; Take by weighing Radix Saposhnikoviae 8 grams after the above-mentioned drying, Herba Schizonepetae 8 grams, Rhizoma Imperatae 12 grams, Flos Lonicerae 12 grams, Radix Scutellariae 8 grams, Fructus Forsythiae 12 grams, Herba Violae 12 grams, Flos Chrysanthemi 8 grams, Herba Taraxaci 25 grams, rhizoma sparganic 5 grams, Rhizoma Curcumae 5 grams, Cortex Moutan 8 grams, Fructus Gardeniae 8 grams, pollen 12 grams, Fructus Mume 8 grams, Radix Clematidis 12 grams, Radix Arnebiae (Radix Lithospermi) 12 grams, Radix Isatidis 12 grams, Folium Isatidis 12 grams, Herba Portulacae 8 grams, Radix Curcumae 8 grams, Radix Salviae Miltiorrhizae 12 grams, Gypsum Fibrosum 25 grams, Fructus Arctii 12 grams, the Radix Paeoniae Alba 8 grams, the Rhizoma Anemarrhenae 8 grams, the Rhizoma Pinelliae 8 grams, the Radix Linderae 8 grams, Pericarpium Citri Reticulatae 8 grams, Poria 8 grams, Radix Asparagi 8 grams, Fructus Atriplicis Sibiricae 12 grams, Bombyx Batryticatus 8 grams, restrain Radix Ophiopogonis 8.Afterwards, above-mentioned all the other crude drug except that Gypsum Fibrosum that take by weighing are mixed.

The unmixing Gypsum Fibrosum that takes by weighing 25 grams were put into water fried 15 minutes; Afterwards above-mentioned mixed crude drug is put into fried again 15 minutes; Above-mentioned Chinese medicine after fried is filtered, and it is fried that the medicinal residues that obtain are carried out secondary, fried 15 minutes; Above-mentioned twice fried water preparation mixing that obtains can be obtained the psoriasic Chinese medicine for oral administration water preparation of treatment of the present invention.

Embodiment 3

Select quality raw materials medicine Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Imperatae, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Herba Violae, Flos Chrysanthemi, Herba Taraxaci, rhizoma sparganic, Rhizoma Curcumae, Cortex Moutan, Fructus Gardeniae, pollen, Fructus Mume, Radix Clematidis, Radix Arnebiae (Radix Lithospermi), Radix Isatidis, Folium Isatidis, Herba Portulacae, Radix Curcumae, Radix Salviae Miltiorrhizae, Gypsum Fibrosum, Fructus Arctii, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, the Rhizoma Pinelliae, the Radix Linderae, Pericarpium Citri Reticulatae, Poria, Radix Asparagi, Fructus Atriplicis Sibiricae, Bombyx Batryticatus, Radix Ophiopogonis, above-mentioned medical material is placed in the dehydrator, above-mentioned medical material is dried 1h in 45 ℃; Take by weighing Radix Saposhnikoviae 12 grams after the above-mentioned drying, Herba Schizonepetae 12 grams, Rhizoma Imperatae 18 grams, Flos Lonicerae 18 grams, Radix Scutellariae 12 grams, Fructus Forsythiae 18 grams, Herba Violae 18 grams, Flos Chrysanthemi 12 grams, Herba Taraxaci 35 grams, rhizoma sparganic 7 grams, Rhizoma Curcumae 7 grams, Cortex Moutan 12 grams, Fructus Gardeniae 12 grams, pollen 18 grams, Fructus Mume 12 grams, Radix Clematidis 18 grams, Radix Arnebiae (Radix Lithospermi) 18 grams, Radix Isatidis 18 grams, Folium Isatidis 18 grams, Herba Portulacae 12 grams, Radix Curcumae 12 grams, Radix Salviae Miltiorrhizae 18 grams, Gypsum Fibrosum 35 grams, Fructus Arctii 18 grams, the Radix Paeoniae Alba 12 grams, the Rhizoma Anemarrhenae 12 grams, the Rhizoma Pinelliae 12 grams, the Radix Linderae 12 grams, Pericarpium Citri Reticulatae 12 grams, Poria 12 grams, Radix Asparagi 12 grams, Fructus Atriplicis Sibiricae 18 grams, Bombyx Batryticatus 12 grams, restrain Radix Ophiopogonis 12.Afterwards, above-mentioned all the other crude drug except that Gypsum Fibrosum that take by weighing are mixed.

The unmixing Gypsum Fibrosum that takes by weighing 35 grams were put into water fried 20 minutes; Afterwards above-mentioned mixed crude drug is put into fried again 25 minutes; Above-mentioned Chinese medicine after fried is filtered, and it is fried that the medicinal residues that obtain are carried out secondary, fried 25 minutes; Above-mentioned twice fried water preparation mixing that obtains can be obtained the psoriasic Chinese medicine for oral administration water preparation of treatment of the present invention.

Embodiment 4

Select quality raw materials medicine Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Imperatae, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Herba Violae, Flos Chrysanthemi, Herba Taraxaci, rhizoma sparganic, Rhizoma Curcumae, Cortex Moutan, Fructus Gardeniae, pollen, Fructus Mume, Radix Clematidis, Radix Arnebiae (Radix Lithospermi), Radix Isatidis, Folium Isatidis, Herba Portulacae, Radix Curcumae, Radix Salviae Miltiorrhizae, Gypsum Fibrosum, Fructus Arctii, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, the Rhizoma Pinelliae, the Radix Linderae, Pericarpium Citri Reticulatae, Poria, Radix Asparagi, Fructus Atriplicis Sibiricae, Bombyx Batryticatus, Radix Ophiopogonis, above-mentioned medical material is placed in the dehydrator, above-mentioned medical material is dried 1h in 45 ℃; Medical material after the above-mentioned oven dry is pulverized, and crossed 200 mesh sieves; Take by weighing Radix Saposhnikoviae 10 grams after above-mentioned drying is pulverized, Herba Schizonepetae 10 grams, Rhizoma Imperatae 15 grams, Flos Lonicerae 15 grams, Radix Scutellariae 10 grams, Fructus Forsythiae 15 grams, Herba Violae 15 grams, Flos Chrysanthemi 10 grams, Herba Taraxaci 30 grams, rhizoma sparganic 6 grams, Rhizoma Curcumae 6 grams, Cortex Moutan 10 grams, Fructus Gardeniae 10 grams, pollen 15 grams, Fructus Mume 10 grams, Radix Clematidis 15 grams, Radix Arnebiae (Radix Lithospermi) 15 grams, Radix Isatidis 15 grams, Folium Isatidis 15 grams, Herba Portulacae 10 grams, Radix Curcumae 10 grams, Radix Salviae Miltiorrhizae 15 grams, Gypsum Fibrosum 30 grams, Fructus Arctii 15 grams, the Radix Paeoniae Alba 10 grams, the Rhizoma Anemarrhenae 10 grams, the Rhizoma Pinelliae 10 grams, the Radix Linderae 10 grams, Pericarpium Citri Reticulatae 10 grams, Poria 10 grams, Radix Asparagi 10 grams, Fructus Atriplicis Sibiricae 15 grams, Bombyx Batryticatus 10 grams, restrain Radix Ophiopogonis 10.Afterwards, above-mentioned all the other crude drug except that Gypsum Fibrosum that take by weighing are mixed.

The unmixing Gypsum Fibrosum that takes by weighing 30 grams were put into water fried 25 minutes; Afterwards above-mentioned mixed crude drug is put into fried again 25 minutes; Above-mentioned Chinese medicine after fried is filtered, and it is fried that the medicinal residues that obtain are carried out secondary, fried 25 minutes; Above-mentioned twice fried water preparation mixing that obtains can be obtained the psoriasic Chinese medicine for oral administration water preparation of treatment of the present invention.

Embodiment 5

Select quality raw materials medicine Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Imperatae, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Herba Violae, Flos Chrysanthemi, Herba Taraxaci, rhizoma sparganic, Rhizoma Curcumae, Cortex Moutan, Fructus Gardeniae, pollen, Fructus Mume, Radix Clematidis, Radix Arnebiae (Radix Lithospermi), Radix Isatidis, Folium Isatidis, Herba Portulacae, Radix Curcumae, Radix Salviae Miltiorrhizae, Gypsum Fibrosum, Fructus Arctii, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, the Rhizoma Pinelliae, the Radix Linderae, Pericarpium Citri Reticulatae, Poria, Radix Asparagi, Fructus Atriplicis Sibiricae, Bombyx Batryticatus, Radix Ophiopogonis, above-mentioned medical material is placed in the dehydrator, above-mentioned medical material is dried 0.5h in 50 ℃; Take by weighing Radix Saposhnikoviae 15 grams after the above-mentioned drying, Herba Schizonepetae 15 grams, Rhizoma Imperatae 20 grams, Flos Lonicerae 20 grams, Radix Scutellariae 15 grams, Fructus Forsythiae 20 grams, Herba Violae 20 grams, Flos Chrysanthemi 15 grams, Herba Taraxaci 40 grams, rhizoma sparganic 9 grams, Rhizoma Curcumae 9 grams, Cortex Moutan 15 grams, Fructus Gardeniae 15 grams, pollen 20 grams, Fructus Mume 15 grams, Radix Clematidis 20 grams, Radix Arnebiae (Radix Lithospermi) 20 grams, Radix Isatidis 20 grams, Folium Isatidis 20 grams, Herba Portulacae 15 grams, Radix Curcumae 15 grams, Radix Salviae Miltiorrhizae 20 grams, Gypsum Fibrosum 40 grams, Fructus Arctii 20 grams, the Radix Paeoniae Alba 15 grams, the Rhizoma Anemarrhenae 15 grams, the Rhizoma Pinelliae 15 grams, the Radix Linderae 15 grams, Pericarpium Citri Reticulatae 15 grams, Poria 15 grams, Radix Asparagi 15 grams, Fructus Atriplicis Sibiricae 20 grams, Bombyx Batryticatus 15 grams, restrain Radix Ophiopogonis 15.Afterwards, above-mentioned all the other crude drug except that Gypsum Fibrosum that take by weighing are mixed.

The unmixing Gypsum Fibrosum that takes by weighing 38 grams were put into water fried 35 minutes; Afterwards above-mentioned mixed crude drug is put into fried again 35 minutes; Above-mentioned Chinese medicine after fried is filtered, and it is fried that the medicinal residues that obtain are carried out secondary, fried 35 minutes; Above-mentioned twice fried water preparation mixing that obtains can be obtained the psoriasic Chinese medicine for oral administration water preparation of treatment of the present invention.

Embodiment 6

Select quality raw materials medicine Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Imperatae, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Herba Violae, Flos Chrysanthemi, Herba Taraxaci, rhizoma sparganic, Rhizoma Curcumae, Cortex Moutan, Fructus Gardeniae, pollen, Fructus Mume, Radix Clematidis, Radix Arnebiae (Radix Lithospermi), Radix Isatidis, Folium Isatidis, Herba Portulacae, Radix Curcumae, Radix Salviae Miltiorrhizae, Gypsum Fibrosum, Fructus Arctii, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, the Rhizoma Pinelliae, the Radix Linderae, Pericarpium Citri Reticulatae, Poria, Radix Asparagi, Fructus Atriplicis Sibiricae, Bombyx Batryticatus, Radix Ophiopogonis, above-mentioned medical material is placed in the dehydrator, above-mentioned medical material is dried 1h in 45 ℃; Medical material after the above-mentioned oven dry is pulverized, and crossed 200 mesh sieves; Take by weighing Radix Saposhnikoviae 10 grams after above-mentioned drying is pulverized, Herba Schizonepetae 10 grams, Rhizoma Imperatae 15 grams, Flos Lonicerae 15 grams, Radix Scutellariae 10 grams, Fructus Forsythiae 15 grams, Herba Violae 15 grams, Flos Chrysanthemi 10 grams, Herba Taraxaci 30 grams, rhizoma sparganic 6 grams, Rhizoma Curcumae 6 grams, Cortex Moutan 10 grams, Fructus Gardeniae 10 grams, pollen 15 grams, Fructus Mume 10 grams, Radix Clematidis 15 grams, Radix Arnebiae (Radix Lithospermi) 15 grams, Radix Isatidis 15 grams, Folium Isatidis 15 grams, Herba Portulacae 10 grams, Radix Curcumae 10 grams, Radix Salviae Miltiorrhizae 15 grams, Gypsum Fibrosum 30 grams, Fructus Arctii 15 grams, the Radix Paeoniae Alba 10 grams, the Rhizoma Anemarrhenae 10 grams, the Rhizoma Pinelliae 10 grams, the Radix Linderae 10 grams, Pericarpium Citri Reticulatae 10 grams, Poria 10 grams, Radix Asparagi 10 grams, Fructus Atriplicis Sibiricae 15 grams, Bombyx Batryticatus 10 grams, restrain Radix Ophiopogonis 10.Afterwards, above-mentioned all the other crude drug except that Gypsum Fibrosum that take by weighing are mixed.

The unmixing Gypsum Fibrosum that takes by weighing 30 grams were put into water fried 20 minutes; Afterwards above-mentioned mixed crude drug is put into fried again 20 minutes; Above-mentioned Chinese medicine after fried is filtered, and it is fried that the medicinal residues that obtain are carried out secondary, fried 20 minutes; Above-mentioned twice fried water preparation mixing that obtains can be obtained the psoriasic Chinese medicine for oral administration water preparation of treatment of the present invention.

In the foregoing description, what provide is the water aqua type endo-medicine, and as embodiment that can conversion, this medicine can be prepared into electuary granule, tablet, capsule, the watered pill, honeyed pill with it by using conventional preparation method.

Experimental example:

Medication is: with the water aqua type Chinese medicine for oral administration for preparing in the foregoing description, took in one day at twice, Time of Administration is half an hour after meal.

The course of treatment: 7 times is a course of treatment

In order to show the therapeutic effect of this Chinese medicine for oral administration, the present invention is through the clinical observation of 21350 routine systems, among this 21350 routine patient, erythroderma type psoriatic 150 examples, pustule type psoriatic 5100 examples, acute psoriasis punctata patient 11840 examples of homeliness type, the chronic patch shape of homeliness type psoriatic 4260 examples.In the process of above-mentioned clinical observation, and the work of above-mentioned patient being write down its medical history, the state of an illness, age and curative effect.

The criterion of clinical therapeutic efficacy is:

Clinical cure: skin lesion complete obiteration or only stay several unconspicuous point erythra.

Produce effects: erythra disappears more than 85%, and pruritus obviously alleviates.

Effectively: between the deflorescence 30%-80%, pruritus alleviates.

Invalid: deflorescence is not obvious or increase the weight of.

Above-mentioned clinical efficacy writes down as following table:

At this, the part model case of the above-mentioned clinical data of enclosing illustrates that with this this treats the clinical efficacy of psoriasic Chinese medicine for oral administration:

Disease one: erythroderma type psoriasis

Patient Qiao Jun: the man, 16 years old, Cuba city, Inner Mongol bordered on the river Da Dan township student.

Patient's whole body plays point-like, and patch shape psoriasis 10 years is surplus.Occurred back and shirtfront after being soaked with rain at that time and play red little pimple, above the adularescent squama, after scraping petechial hemorrhage is arranged, behind the Ceng Zaihang, invalid always after preceding flag and the hospitalizes such as 279 of bordering on the river.98 year autumn, the state of an illness increased the weight of.

Have a medical check-up: scalp trunk extremity and hand-foot skin all are covered with erythema, pimple.10 multi-discs (3 * 10 big pimple yellow crusts) are arranged, the bent side of health, fold place all has the yellow crusts of festering and pustule, conscious whole skin pain, especially with cervical region/oxter/groin pain more very, the skin lesion area accounts for more than 95% of whole body area.At that time with lymphadenectasis, 39.5 ℃ of body temperature, thready and rapid pulse, big dry stool, xerostomia etc.

Fully recover after 8 courses of treatment through taking Chinese medicine for oral administration of the present invention, whole skin is all normal, and the body temperature enlargement of lymph node is also normal, and treatment time only is February.Visited not recurrence always in 99 years.

Patient Mo Rigen: man, 57 years old, Hu Shi military region cadre.

Year surplus patient's whole body large tracts of land psoriasis 30.The point-like erythra appears in make moist trunk behind the wind-engaging, extremity of army's camping and field trining at that time, and basilar part is scarlet, covers white squama above, once in BJ Union Hospital, exhale the attached institute in city, Aer Mountain sanatorium to fail to respond to any medical treatment.Calendar year 2001, the state of an illness increased the weight of.

Have a medical check-up: women's head-ornaments, trunk, extremity skin are covered with intensive red pimple, be coated with white squama above, position skin lesion such as hands, elbow, knee are linked to be big lamellar, account for 99% of whole body area, the squama that extremity harden has coin thick approximately, limitation of activity is simultaneously with symptoms such as fervescence, lymphadenectasis, xerostomia, thirsty, vexed, red tongue.

Taking Chinese medicine for oral administration of the present invention fully recovered after 15 courses of treatment.Visited not recurrence always in 2002.

Disease two: pustule type psoriasis

Patient Cui Yuqing: man, 57 years old, Dengkou, Cuba city, Inner Mongol building site peasant.

It is surplus that pustule 8 years appears in the patient brothers heart, in the locality, Yinchuan, that ground such as border on the river has been seen is invalid.

Have a medical check-up: brothers' heart is covered with yellow pustule, local redness, pain, decortication, pruritus, limitation of activity, red tongue, thready and rapid pulse.

Took Chinese medicine for oral administration of the present invention in 1994 and fully recover after 8 courses of treatment, it is normal that skin recovers fully.Visited not recurrence always in 96 years.

Disease three: the acute psoriasis punctata of homeliness type

Patient Tu Ya: woman, 45 years old, Inner Mongol Jining City peasant.

Patient's whole body plays red little pimple, surplus the top secretion squama ten year, fails to respond to any medical treatment on Hu Shi, Jining and other places.

Have a medical check-up: whole body is covered with the red little pimple of intensive point-like, and the silvery white squama of secretion has the petechia after scraping on the pimple, and big leg outer side is with xerostomia, thirsty, dizzy, pharyngalgia, constipation greatly, red tongue, thready and rapid pulse.

Calendar year 2001 begins to take Chinese medicine for oral administration of the present invention, takes only 4 courses of treatment, and the red little pimple of whole body is complete obiteration, and it is normal that skin recovers.Visited not recurrence always in 2002.

Patient Jin Le: woman, 18 years old, Baotou, Inner Mongol student.

Patient's calendar year 2001 whole body plays red point-like pimple, is acute psoriasis punctata at the Baotou hospital diagnosis, and is invalid in how tame hospitalizes such as Hu Shi, packet header.

Have a medical check-up: whole skin has more red pimple, and secretion adularescent squama has netted petechia after scraping above, and scalp, face, extremity all have, with xerostomia, thirsty, red tongue, thready and rapid pulse.

Promptly fully recover after 3 courses of treatment through taking Chinese medicine for oral administration of the present invention.Visited not recurrence always in 2002.

Disease four: the chronic patch shape of homeliness type psoriasis

The patient clings to Tu Wuliji: man, 57 years old, Inner Mongol Xi Meng pure yellow banner herdsman.

Red little pimple appears in patient's whole body in 1993, is linked to be the patch shape then, once at Xi Meng, exhale large hospital treatment in city invalid for many years.

Have a medical check-up: the big lamellar erythema of whole body, a lot of white squamas of secretion on the erythema, scalp and extremity squama are very thick.Squama is scraped the back and netted petechia occurred, extremities joint joint stuffiness, red tongue, few Tianjin, wiry and frequent pulse.

Calendar year 2001 begins to take Chinese medicine for oral administration of the present invention, after 12 courses of treatment, and whole body erythema, squama complete obiteration.Visited not recurrence always in 2002.

Though the present invention elaborates it by the above-mentioned specific embodiment; but; the any form that does not exceed the claim protection domain that those skilled in the art should be understood that on this basis to be made and the variation of details all belong to invention which is intended to be protected.

Claims (6)

1, the psoriasic Chinese medicine for oral administration of a kind of treatment is characterized in that the weight portion of the crude drug of this Chinese medicine for oral administration is:

Radix Saposhnikoviae 5～15, Herba Schizonepetae 5～15, Rhizoma Imperatae 10～20, Flos Lonicerae 10～20, Radix Scutellariae 5～15, Fructus Forsythiae 10～20, Herba Violae 10～20, Flos Chrysanthemi 5～15, Herba Taraxaci 20～40, rhizoma sparganic 2～9, Rhizoma Curcumae 2～9, Cortex Moutan 5～15, Fructus Gardeniae 5～15, pollen 10～20, Fructus Mume 5～15, Radix Clematidis 10～20, Radix Arnebiae (Radix Lithospermi) 10～20, Radix Isatidis 10～20, Folium Isatidis 10～20, Herba Portulacae 5～15, Radix Curcumae 5～15, Radix Salviae Miltiorrhizae 10～20, Gypsum Fibrosum 20～40, Fructus Arctii 10～20, the Radix Paeoniae Alba 5～15, the Rhizoma Anemarrhenae 5～15, the Rhizoma Pinelliae 5～15, the Radix Linderae 5～15, Pericarpium Citri Reticulatae 5～15, Poria 5～15, Radix Asparagi 5～15, Fructus Atriplicis Sibiricae 10～20, Bombyx Batryticatus 5～15, Radix Ophiopogonis 5～15.

2, the psoriasic Chinese medicine for oral administration of treatment according to claim 1 is characterized in that, the weight portion of described Chinese medicine for oral administration crude drug is:

Radix Saposhnikoviae 8～12, Herba Schizonepetae 8～12, Rhizoma Imperatae 12～18, Flos Lonicerae 12～18, Radix Scutellariae 8～12, Fructus Forsythiae 12～18, Herba Violae 12～18, Flos Chrysanthemi 8～12, Herba Taraxaci 25～35, rhizoma sparganic 5～7, Rhizoma Curcumae 5～7, Cortex Moutan 8～12, Fructus Gardeniae 8～12, pollen 12～18, Fructus Mume 8～12, Radix Clematidis 12～18, Radix Arnebiae (Radix Lithospermi) 12～18, Radix Isatidis 12～18, Folium Isatidis 12～18, Herba Portulacae 8～12, Radix Curcumae 8～12, Radix Salviae Miltiorrhizae 12～18, Gypsum Fibrosum 25～35, Fructus Arctii 12～18, the Radix Paeoniae Alba 8～12, the Rhizoma Anemarrhenae 8～12, the Rhizoma Pinelliae 8～12, the Radix Linderae 8～12, Pericarpium Citri Reticulatae 8～12, Poria 8～12, Radix Asparagi 8～12, Fructus Atriplicis Sibiricae 12～18, Bombyx Batryticatus 8～12, Radix Ophiopogonis 8～12.

3, the psoriasic Chinese medicine for oral administration of treatment according to claim 1 is characterized in that, the weight portion of described Chinese medicine for oral administration crude drug is:

Radix Saposhnikoviae 10, Herba Schizonepetae 10, Rhizoma Imperatae 15, Flos Lonicerae 15, Radix Scutellariae 10, Fructus Forsythiae 15, Herba Violae 15, Flos Chrysanthemi 10, Herba Taraxaci 30, rhizoma sparganic 6, Rhizoma Curcumae 6, Cortex Moutan 10, Fructus Gardeniae 10, pollen 15, Fructus Mume 10, Radix Clematidis 15, Radix Arnebiae (Radix Lithospermi) 15, Radix Isatidis 15, Folium Isatidis 15, Herba Portulacae 10, Radix Curcumae 10, Radix Salviae Miltiorrhizae 15, Gypsum Fibrosum 30, Fructus Arctii 15, the Radix Paeoniae Alba 10, the Rhizoma Anemarrhenae 10, the Rhizoma Pinelliae 10, the Radix Linderae 10, Pericarpium Citri Reticulatae 10, Poria 10, Radix Asparagi 10, Fructus Atriplicis Sibiricae 15, Bombyx Batryticatus 10, Radix Ophiopogonis 10.

4, according to claim 1 or the psoriasic Chinese medicine for oral administration of 2 or 3 arbitrary described treatments, it is characterized in that the dosage form of described Chinese medicine for oral administration is water preparation, powder or honeyed pill.

5, the water preparation preparation method of claim 1 or the psoriasic Chinese medicine for oral administration of 2 or 3 arbitrary described treatments, it comprises the steps:

(1) selects quality raw materials medicine medical material, above-mentioned medical material is placed in the dehydrator, above-mentioned medical material is dried in 35～50 ℃;

(2) take by weighing the crude drug of the drying of specified weight part, the crude drug except that Gypsum Fibrosum that takes by weighing is mixed;

(3) the unmixing Gypsum Fibrosum that takes by weighing is put into water and carried out fried 10～35 minutes, will put into fried 10～35 minutes through the mixed crude drug of step (2) afterwards;

(4) it is fried to carry out secondary through the medicinal residues that step (3) after-filtration obtains, and the fried time is 10～35 minutes;

(5) water preparation that step (3) and step (4) are obtained mixes and gets final product.

6, the water preparation preparation method of the psoriasic Chinese medicine for oral administration of treatment according to claim 5 is characterized in that, before described step (2) is mixed the crude drug after the drying, described crude drug is pulverized, and is crossed 200 mesh sieves.