CN105367510A - 一种(2R,4S)-3-Cbz-2,4-二苯基-1,3-恶唑烷-5-酮的制备方法 - Google Patents
一种(2R,4S)-3-Cbz-2,4-二苯基-1,3-恶唑烷-5-酮的制备方法 Download PDFInfo
- Publication number
- CN105367510A CN105367510A CN201510734205.7A CN201510734205A CN105367510A CN 105367510 A CN105367510 A CN 105367510A CN 201510734205 A CN201510734205 A CN 201510734205A CN 105367510 A CN105367510 A CN 105367510A
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- Prior art keywords
- cbz
- ketone
- phenylbenzene
- reaction
- condensation reaction
- Prior art date
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- MKDHTMOOUROILV-UHFFFAOYSA-N CCCCOC(NC(C)CC)Cl Chemical compound CCCCOC(NC(C)CC)Cl MKDHTMOOUROILV-UHFFFAOYSA-N 0.000 description 1
- LGPXGZNWQRYPKE-PMSRRNCFSA-N C[C@H](CF)/C=C(/C)\C=C/C Chemical compound C[C@H](CF)/C=C(/C)\C=C/C LGPXGZNWQRYPKE-PMSRRNCFSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510734205.7A CN105367510B (zh) | 2015-11-02 | 2015-11-02 | 一种(2R,4S)‑3‑Cbz‑2,4‑二苯基‑1,3‑恶唑烷‑5‑酮的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510734205.7A CN105367510B (zh) | 2015-11-02 | 2015-11-02 | 一种(2R,4S)‑3‑Cbz‑2,4‑二苯基‑1,3‑恶唑烷‑5‑酮的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN105367510A true CN105367510A (zh) | 2016-03-02 |
CN105367510B CN105367510B (zh) | 2017-07-21 |
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Family Applications (1)
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CN201510734205.7A Active CN105367510B (zh) | 2015-11-02 | 2015-11-02 | 一种(2R,4S)‑3‑Cbz‑2,4‑二苯基‑1,3‑恶唑烷‑5‑酮的制备方法 |
Country Status (1)
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CN (1) | CN105367510B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1606545A (zh) * | 2001-12-18 | 2005-04-13 | 先灵公司 | 作为nk1拮抗剂的吡咯烷和哌啶衍生物 |
CN100509782C (zh) * | 2001-11-13 | 2009-07-08 | 先灵公司 | Nk1拮抗剂 |
-
2015
- 2015-11-02 CN CN201510734205.7A patent/CN105367510B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100509782C (zh) * | 2001-11-13 | 2009-07-08 | 先灵公司 | Nk1拮抗剂 |
CN1606545A (zh) * | 2001-12-18 | 2005-04-13 | 先灵公司 | 作为nk1拮抗剂的吡咯烷和哌啶衍生物 |
Non-Patent Citations (1)
Title |
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MARTIN J. O"DONNELL ET AL.: "New Methodology for the Synthesis of α,α-Dialkylamino Acids Using the "Self-Regeneration of Stereocenters" Method: α-Ethyl-α-phenylglycine", 《HETEROCYCLES》 * |
Also Published As
Publication number | Publication date |
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CN105367510B (zh) | 2017-07-21 |
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Effective date of registration: 20171218 Address after: 201505 Shanghai Jinshan District exhibition pavilion Lin Zhen Jin Road No. 2229 Building No. 6 room 880 Patentee after: Xishi Chemical Technology (Shanghai) Co., Ltd. Address before: 318000 School of Biochemistry, Taizhou Vocational and Technical College, Jiaojiang District, Taizhou, Zhejiang Province, No. 788, Taizhou Vocational and Technical College Co-patentee before: Taizhou Vocational & Technical College Patentee before: Ye Haiwei |
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Effective date of registration: 20211101 Address after: 201100 room 338, third floor, building 1, No. 786, Hongmei South Road, Minhang District, Shanghai Patentee after: Shanghai Haichen Pharmaceutical Technology Co.,Ltd. Address before: 201505 room 880, building 6, No. 2229, Jinzhan Road, Tinglin Town, Jinshan District, Shanghai Patentee before: Xishi Chemical Technology (Shanghai) Co.,Ltd. |