CN105363010A - 一种治疗产后腹痛的药物及其制备方法 - Google Patents
一种治疗产后腹痛的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗产后腹痛的药物及其制备方法,其主要是由淫羊藿、茜草根、山楂、益母草、当归、干姜、苏木、鱼腥草、蒲公英、蒲黄、吴茱萸、香附、五灵脂、鸡冠花、乳香、牛膝、丝瓜络、泽兰、卷柏、枳实、小蒜香、丹参、薏苡仁、红花按一定重量配比制备而成。本发明药物具有补血益气,活血化瘀,温经止痛的功能,用于治疗产后腹痛见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗产后腹痛的药物及其制备方法,属中药领域。
背景技术
产后腹痛是指在产褥期内,发生与分娩或产褥有关的小腹疼痛。中医则认为产后腹痛多因气血运行不畅而致。由于西药治疗产后腹痛副作用大,因此人们对有效治疗产后腹痛的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人经过反复的研究和临床试验的反复验证,终于找到了有效治疗产后腹痛的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗产后腹痛的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择淫羊藿、茜草根、山楂、益母草、当归、干姜、苏木、鱼腥草、蒲公英、蒲黄、吴茱萸、香附、五灵脂、鸡冠花、乳香、牛膝、丝瓜络、马鞭草、延胡索、泽兰、牡丹皮、桑寄生、卷柏、枳实、小蒜香、丹参、薏苡仁、红花药物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗产后腹痛。其中,选用淫羊藿是因为其性味辛甘,温,入肝、肾经,有补肾壮阳,祛风除湿的功能,治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿痹痛,四脚不仁。选用茜草根是因为其性味苦,寒,入心、肝经,有行血止血,通经活络,止咳祛痰的功能,治吐血,衄血,尿血,便血,血崩,经闭,风湿痹痛,跌打损伤,瘀滞肿痛,黄疸,性性气管炎。选用山楂是因为其性味酸甘,微温,入脾、胃、肝经,有消食积,散瘀血,驱绦虫的功能,治肉积,癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气,产后儿枕痛,恶露不尽,小儿乳食停滞。选用益母草是因为其性味辛苦,凉,入心包、肝经,有活血,祛瘀,调经,消水的功能,治月经不调,治漏难产,胞衣不下,产后血晕,瘀血腹痛,崩中漏下,尿血,泻血,痈肿疮疡。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用干姜是因为其性味辛,热,入脾、胃、肺经,有温中逐寒,回阳通脉的功能,治心腹冷痛,吐泻,肢冷脉微,寒饮喘咳,风寒湿痹,阳虚吐、衄、下血。选用苏木是因为其性味甘、咸、平,归心、肝、脾经,有行血,破瘀,消肿,止痛的功能,治外伤肿痛,经闭痛经,产后瘀血,胸腹刺痛,痢疾,破伤风。选用鱼腥草是因为其性味辛,寒,入手太阴经,有清热解毒,利尿消肿的功能,治肺炎,肺脓疡,热痢,疟疾,水肿,淋病,白带,痈肿,痔疮,脱肛,湿疹,秃疮,疥癣。选用蒲公英是因为其性味苦甘,寒,入肝、胃经,有清热解毒,利尿散结的功能,治急性乳腺炎,淋巴腺炎,瘰疬,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急性支气管炎,胃炎,肝炎,胆囊炎,尿路感染。选用蒲黄是因为其性味甘辛苦,凉,入肝、心经,有凉血止血,活血消瘀的功能,生用治经闭腹痛,产后瘀阻作痛,跌扑血闷,疮疖肿毒,炒黑止吐血,衄血,崩漏,泻血,尿血,血痢,带下,外治重舌,口疮,聤耳流脓,耳中出血,阴下湿痒。选用吴茱萸是因为其性味辛苦,温,有毒,入肝、胃经,有温中,止痛,理气,燥湿的功能,治呕逆吞酸,厥阴头痛,脏寒吐泻,脘腹胀痛,脚气,疝气,口疮溃疡,齿痛,湿疹,黄水疮。选用香附是因为其性味辛微苦干,平,入肝、三焦经,有理气解郁,止痛调经的功能,治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,月经不调,崩漏带下。选用五灵脂是因为其性味苦甘,温,入肝、脾经,生用有行血止痛的功能,治心腹血气诸痛,妇女经闭,产后瘀血作痛;外治蛇、蝎、蜈蚣咬伤,炒用止血,治妇女血崩,经水过多,赤带不绝。选用鸡冠花是因为其是因为其性味性味甘,凉,入足厥阴肝经,有凉血,止血的功能,治痔漏下血,赤白下痢,吐血,咳血,血淋,妇女崩中,赤白带下。选用乳香是因为其性味辛苦,温,入心、肝、脾经,有调气活血,定痛,追毒的功能,治气血凝滞,心腹疼痛,痈疮肿毒,跌打损伤,痛经,产后瘀血刺痛。选用牛膝是因为其性味苦,酸,平,归肝,肾经,有活血散瘀,祛湿利尿,清热解毒的功能,治淋病,尿血,妇女经闭,症瘕,风湿关节痛,脚气,水肿,痢疾,疟疾,白喉,痈肿,跌打损伤。选用丝瓜络是因为其性味甘,平,归肺、肝、胃经,有通经活络,清热化痰的功能,治胸胁疼痛,腹痛,腰痛,睾丸肿痛,肺热痰咳,妇女经闭,乳汁不通,痈肿,痔漏。选用马鞭草是因为其性味苦,凉,入肝、脾经,有清热解毒,活血散瘀,利水消肿的功能,治外感发热,湿热黄疸,水肿,痢疾,疟疾,白喉,喉痹,淋病,经闭,癥瘕,痈肿疮毒牙疳。选用延胡索是因为其性味辛苦,温,入肝、胃经,有活血,散瘀,理气,止痛的功能,治心腹腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损伤。选用泽兰是因为其性味苦辛,微温,入肝、脾经,有活血,行水的功能,治经闭,癥瘕,产后瘀滞腹痛,身面浮肿,跌扑损伤,金疮,痈肿。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用桑寄生是因为其性味苦甘,平,入肝、肾经,有补肝肾,强筋骨,除风湿,通经络,益血,安胎的功能,治腰膝酸痛,筋骨痿弱,偏枯,脚气,风寒湿痹,胎漏血崩,产后乳汁不下。选用卷柏是因为其性味辛,平,归心、心经,有活血通经的功能,治经闭痛经,癥瘕痞块,跌扑损伤。选用枳实是因为其性味苦,寒,入脾、胃经,有破气,散痞,泻痰,消积的功能,治胸腹胀痛,胸痹,痞痛,痰癖,水肿,食积,便秘,胃下垂,子宫下垂,脱肛。选用小蒜香是因为其性味辛,温,归脾、胃经,有温中、下气,消谷,杀虫的功能,治吐泻,心腹胀痛。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用薏苡仁是因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
淫羊藿15-25克,茜草根12-18克,山楂10-15克,益母草15-25克,当归15-25克,干姜15-25克,苏木10-15克,鱼腥草8-12克,蒲公英8-12克,蒲黄12-18克,吴茱萸5-10克,香附10-15克,五灵脂8-12克,鸡冠花8-12克,乳香10-15克,牛膝10-15克,丝瓜络8-12克,马鞭草8-12克,延胡索8-12克,泽兰10-15克,牡丹皮8-12克,桑寄生15-25克,卷柏10-15克,枳实8-12克,小蒜香12-18克,丹参10-15克,薏苡仁8-12克,红花10-15克。
优选为:
淫羊藿20克,茜草根15克,山楂12克,益母草20克,当归20克,干姜20克,苏木12克,鱼腥草10克,蒲公英10克,蒲黄15克,吴茱萸8克,香附12克,五灵脂10克,鸡冠花10克,乳香12克,牛膝12克,丝瓜络10克,马鞭草10克,延胡索10克,泽兰12克,牡丹皮10克,桑寄生20克,卷柏12克,枳实10克,小蒜香15克,丹参12克,薏苡仁10克,红花12克。
本发明药物的制备方法如下
一、备料
1、淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
2、茜草根:拣净杂质,除去芦苗,洗净,润透后及时切片,晒干;
3、山楂:拣净杂质,筛去核;
4、益母草:拣去杂质,洗净,润透,切段,晒干;
5、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
6、干姜:拣净杂质,用水浸泡3—6小时,捞出,闷润后切片或切成小方块,晒干;
7、苏木:取原药材,锯成短段,再劈成碎片或镑片;
8、鱼腥草:去净杂质,除去残根,洗净切段,晒干;
9、蒲公英:拣去杂质,洗净泥土,切段,晒干;
10、蒲黄:揉碎结块,过筛,除去杂质;
11、吴茱萸:取原药材,除去果柄、枝及杂质,筛去碎屑;
12、香附:拣去杂质,碾成碎粒,簸去细毛及细末;
13、五灵脂:拣净杂质,打碎或筛去灰屑;
14、鸡冠花:拣净杂质,除去茎及种子,剪成小块;
15、乳香:拣去砂子杂质;
16、牛膝:拣去杂质,洗净,润透切段,晒干;
17、丝瓜络:洗净晒干,切段;
18、马鞭草:拣净杂质,洗净,润软切段,晒干;
19、延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
20、泽兰:拣去杂质,除去残根,喷水稍润,切段晒干;
21、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
22、桑寄生:用水洗净,润透,切段,晒干;
23、卷柏:取原药材,除去残留须根、杂质,洗净,稍晾,切段,干燥;
24、枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干;
25、小蒜香:夏秋采挖,去净泥沙,晒干;
26、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
27、薏苡仁:取原药材,除去残留皮壳、杂质;
28、红花:拣净杂质,除去茎叶、蒂头,晒干;
二、制备
1、将所述的淫羊藿、茜草根、山楂、益母草、当归、干姜、苏木、鱼腥草、蒲公英、蒲黄、吴茱萸、香附、五灵脂、鸡冠花、乳香、牛膝、丝瓜络、马鞭草、延胡索、泽兰、牡丹皮、桑寄生、卷柏、枳实、小蒜香、丹参、薏苡仁、红花放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内。
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液。
3、将两次煎煮液混合搅拌均匀即得,分为2剂服用;
组方中淫羊藿有补肾壮阳,祛风除湿的功能为君药;益母草活血,祛瘀,调经,消水;当归有补血和血,调经止痛,润燥滑肠的功能,二者为臣药,三味药共同发挥补肾,补血和血,调经止痛,消水,润燥的作用,治疗产后腹痛效力全面,且以补肾,补血和血为主可治本,桑寄生有补肝肾,强筋骨,除风湿,通经络,益血,安胎的功能为佐药,干姜有温中逐寒,回阳通脉的功能为使药,与余下诸药是治标。
本发明药物具有补血益气,活血化瘀,温经止痛的功能,用于治疗产后腹痛,疗程短、见效快、治愈后不复发。
具体实施方式:
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治产后腹痛门诊患者共32例。
2、诊断标准
产妇身体虚弱,产时产后失血过多,或情志不遂,或有风感寒史。在新产后至产褥期内,产妇出现小腹部阵发性剧烈疼痛,或小腹隐隐作痛,多日不解,不伴寒热,常伴有恶露量少,色紫黯有块,排出不畅;或恶露量少,色淡红。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,6天为一个疗程,连续服用4个疗程。
4、疗效评定标准
显效:产后腹痛症状消失,体质恢复正常,痊愈;
好转:患者小腹阵发性剧烈疼痛现象减轻,产后腹痛症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗产后腹痛患者32例,结果显效28例,显效率为87.5%,好转3例,好转率为9.38%,无效1例,总有效率为96.88%。
Claims (3)
1.一种治疗产后腹痛的药物,其特征在于:它是由下列重量范围内的原料药制成:
淫羊藿15-25克,茜草根12-18克,山楂10-15克,益母草15-25克,当归15-25克,干姜15-25克,苏木10-15克,鱼腥草8-12克,蒲公英8-12克,蒲黄12-18克,吴茱萸5-10克,香附10-15克,五灵脂8-12克,鸡冠花8-12克,乳香10-15克,牛膝10-15克,丝瓜络8-12克,马鞭草8-12克,延胡索8-12克,泽兰10-15克,牡丹皮8-12克,桑寄生15-25克,卷柏10-15克,枳实8-12克,小蒜香12-18克,丹参10-15克,薏苡仁8-12克,红花10-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
淫羊藿20克,茜草根15克,山楂12克,益母草20克,当归20克,干姜20克,苏木12克,鱼腥草10克,蒲公英10克,蒲黄15克,吴茱萸8克,香附12克,五灵脂10克,鸡冠花10克,乳香12克,牛膝12克,丝瓜络10克,马鞭草10克,延胡索10克,泽兰12克,牡丹皮10克,桑寄生20克,卷柏12克,枳实10克,小蒜香15克,丹参12克,薏苡仁10克,红花12克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
(2)茜草根:拣净杂质,除去芦苗,洗净,润透后及时切片,晒干;
(3)山楂:拣净杂质,筛去核;
(4)益母草:拣去杂质,洗净,润透,切段,晒干;
(5)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(6)干姜:拣净杂质,用水浸泡3—6小时,捞出,闷润后切片或切成小方块,晒干;
(7)苏木:取原药材,锯成短段,再劈成碎片或镑片;
(8)鱼腥草:去净杂质,除去残根,洗净切段,晒干;
(9)蒲公英:拣去杂质,洗净泥土,切段,晒干;
(10)蒲黄:揉碎结块,过筛,除去杂质;
(11)吴茱萸:取原药材,除去果柄、枝及杂质,筛去碎屑;
(12)香附:拣去杂质,碾成碎粒,簸去细毛及细末;
(13)五灵脂:拣净杂质,打碎或筛去灰屑;
(14)鸡冠花:拣净杂质,除去茎及种子,剪成小块;
(15)乳香:拣去砂子杂质;
(16)牛膝:拣去杂质,洗净,润透切段,晒干;
(17)丝瓜络:洗净晒干,切段;
(18)马鞭草:拣净杂质,洗净,润软切段,晒干;
(19)延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
(20)泽兰:拣去杂质,除去残根,喷水稍润,切段晒干;
(21)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(22)桑寄生:用水洗净,润透,切段,晒干;
(23)卷柏:取原药材,除去残留须根、杂质,洗净,稍晾,切段,干燥;
(24)枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干;
(25)小蒜香:夏秋采挖,去净泥沙,晒干;
(26)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(27)薏苡仁:取原药材,除去残留皮壳、杂质;
(28)红花:拣净杂质,除去茎叶、蒂头,晒干;
(二)制备
(1)将所述的淫羊藿、茜草根、山楂、益母草、当归、干姜、苏木、鱼腥草、蒲公英、蒲黄、吴茱萸、香附、五灵脂、鸡冠花、乳香、牛膝、丝瓜络、马鞭草、延胡索、泽兰、牡丹皮、桑寄生、卷柏、枳实、小蒜香、丹参、薏苡仁、红花放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀即得,分为2剂服用。
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