CN105362738B - Pharmaceutical composition and preparation method thereof for livestock and poultry liver protection shield kidney - Google Patents

Pharmaceutical composition and preparation method thereof for livestock and poultry liver protection shield kidney Download PDF

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CN105362738B
CN105362738B CN201510778126.6A CN201510778126A CN105362738B CN 105362738 B CN105362738 B CN 105362738B CN 201510778126 A CN201510778126 A CN 201510778126A CN 105362738 B CN105362738 B CN 105362738B
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parts
radix
livestock
protection shield
liver protection
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CN105362738A (en
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汪安国
刘文利
王尚明
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SHANDONG SOOCOM ANIMAL REMEDY CO.,LTD.
Shandong xundakang Biotechnology Co., Ltd
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Shandong Xundakang Biological Science & Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding

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Abstract

The present invention relates to a kind of pharmaceutical compositions for livestock and poultry liver protection shield kidney, are formed by following components mixed preparing in parts by weight: 15-65 parts of soybean lecithin, 10-30 parts of dandelion, 15-45 parts of dried orange peel, 10-20 parts of fructus lycii, 15-35 parts of radix paeoniae rubra, 15-35 parts of Radix Glycyrrhizae, 10-50 parts of rhizoma imperatae, 15-35 parts of lophatherum gracile, 15-45 parts of Poria cocos, 15-55 parts of radix bupleuri, 15-35 parts of Radix Astragali, 15-35 parts of radix scutellariae, 15-45 parts of Schisandra chinensis, 15-35 parts of rhizoma alismatis.The beneficial effects of the present invention are: reasonable recipe, preparation is simple, and the composition has no toxic side effect, drug residue free, has no drug resistance, and pulverizes, bioavilability height, and clinic proves there is special efficacy to enhancing livestock and poultry liver protection shield kidney health.

Description

Pharmaceutical composition and preparation method thereof for livestock and poultry liver protection shield kidney
Technical field
The present invention relates to the pharmaceutical compositions and preparation method thereof for livestock and poultry liver protection shield kidney, belong to feed addictive neck Domain, in particular to a kind of pharmaceutical composition and preparation method thereof dedicated for livestock and poultry liver protection shield kidney.
Background technique
Liver and kidney of livestock and poultry be damaged it is related with many factors, mainly with disease infection, feed mold, water pollution, drug The factors such as toxic side effect are related, and such case can occur throughout the year, be influence poultry industry develop in a healthy way principal element it One.
For doctor trained in Western medicine mainly to add based on antimicrobial, vitamin, microelement etc., effect is less desirable.
Currently, for livestock and poultry liver protection shield kidney, the most commonly used is Chinese medicines and Western medicine, and Chinese medicine is since its prescription is unreasonable or is Simple to crush, partial size is excessive, and drug release is slower, causes its bioavilability lower, and effect is not fine；And resist in Western medicine Bacterium medicine is due to the problems such as its toxic side effect is strong and medicament residue, using being very limited.
Therefore research and develop it is a kind of for livestock and poultry liver protection shield the having no toxic side effect of kidney, the specific medicament of drug residue free is the field Scientific research technical staff one of new issue anxious to be resolved.
Summary of the invention
It is an object of the present invention to overcome the above deficiencies, provide a kind of reasonable recipe, preparation is simple, pulverize, The pharmaceutical composition effective for livestock and poultry liver protection shield kidney that bioavilability is high, effect is obvious, has no toxic side effect and drug residues And preparation method thereof.
Implementation of the present invention is as follows to achieve the above object: a kind of medicine group for livestock and poultry liver protection shield kidney Object is closed, is formed by following components mixed preparing in parts by weight: 15-65 parts of soybean lecithin, 10-30 parts of dandelion, dried orange peel 15-45 Part, 10-20 parts of fructus lycii, 15-35 parts of radix paeoniae rubra, 15-35 parts of Radix Glycyrrhizae, 10-50 parts of rhizoma imperatae, 15-35 parts of lophatherum gracile, Poria cocos 15-45 Part, 15-55 parts of radix bupleuri, 15-35 parts of Radix Astragali, 15-35 parts of radix scutellariae, 15-45 parts of Schisandra chinensis, 15-35 parts of rhizoma alismatis.
The various component optimum ratio amounts are as follows: 40 parts of soybean lecithin, 20 parts of dandelion, 30 parts of dried orange peel, 15 parts of fructus lycii, red 25 parts of Chinese herbaceous peony, 25 parts of Radix Glycyrrhizae, 30 parts of rhizoma imperatae, 25 parts of lophatherum gracile, 30 parts of Poria cocos, 35 parts of radix bupleuri, 25 parts of Radix Astragali, 25 parts of radix scutellariae, five 30 parts of taste, 25 parts of rhizoma alismatis.
A kind of preparation method of the pharmaceutical composition for livestock and poultry liver protection shield kidney, carries out as follows:
(1) 700 meshes are crossed after pulverizing the various composition in prescription respectively；
(2) 15-65 parts of soybean lecithin, 10-30 parts of dandelion, 15-45 parts of dried orange peel, 10-20 parts of fructus lycii, red is weighed by weight 15-35 parts of Chinese herbaceous peony, 15-35 parts of Radix Glycyrrhizae, 10-50 parts of rhizoma imperatae, mixing 5-10 minutes to uniform；
(3) 15-35 parts of lophatherum gracile, 15-45 parts of Poria cocos, 15-55 parts of radix bupleuri, 15-35 parts of Radix Astragali, radix scutellariae are weighed by weight 15-35 parts, 15-45 parts of Schisandra chinensis, 15-35 parts of rhizoma alismatis, mixing 5-10 minutes to uniform；
(4) merge above-mentioned (2), composition made from (3) step, continues to mix 10-15 minute to uniform.
The medicinal property of each component is as follows:
Soybean lecithin: soybean lecithin is the ester as composed by glycerol, fatty acid, choline or cholamine, and phosphatide is body cell The basis of (cell membrane, nuclear membrane, plastid film), has very high nutritive value and pharmacy value.(1) phosphatide is all life The main composition of cell, the metabolism to cell tissue is promoted, maintains the normal configuration of cell membrane and function to have important Physiological action.(2) lecithin can reduce serum cholesterol level, and can dissolve the cholesterol remained on vascular wall, thus Play prevention cardiovascular and cerebrovascular disease effect.(3) it protects liver from the injury of drug, virus and noxious material, can maintain normal Liver function.(4) lecithin and vitamin E have effect of complementing each other, and can enhance antioxidant activity etc..
Radix Glycyrrhizae: sweet, flat, return lung, the heart, the spleen channel, have invigorate the spleen and benefit qi, expelling phlegm and arresting coughing and middle emergency, removing toxic substances, coordinating the drug actions of a prescription, Alleviate drug toxicity, strong function；Cure mainly weakness of the spleen and the stomach, cough and asthma, poisoning etc..
Dandelion: it is bitter, sweet, cold, return stomach, Liver Channel, has the function of clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia；Cure mainly sore Poison, acute mastitis, pulmonary abscess, hot eyes, pharyngalgia, jaundice with damp-heat pathogen, heat gonorrhea etc..
Fructus lycii: it is sweet, flat, return kidney, Liver Channel, has the function of tonifying the liver and kidney, benefiting shrewd head；Cure mainly the deficiency of liver-yin and kidney-yin, waist without Power, tearing against wind, spermatorrhoea etc..
Radix paeoniae rubra: bitter, slightly cold, return liver warp has the function of clearing heat and cooling blood, promoting blood circulation to remove blood stasis；It is swollen to cure mainly blood under intestines heat, hot eyes Bitterly, sore carbuncle swells, traumatic injury etc..
Rhizoma imperatae: sweet, cold, return lung, stomach, bladder meridian have the function of cooling blood and hemostasis, reducing fever and causing diuresis；Cure mainly bleeding from five sense organs or subcutaneous tissue, urine Blood, heat gonorrhea, oedema etc..
Lophatherum gracile: it is sweet, light, cold, return stomach, the heart, small intestinl channel, has the function of heat-clearing, diuresis；It is short to cure mainly the hot tongue boil of the heart, urine Red, hematuria etc..
Poria cocos: sweet, light, flat, returns spleen, lung, kidney, the heart channel of Hang-Shaoyin have the function of eliminating dampness and diuresis, invigorating the spleen calming heart；Spleen deficiency is cured mainly to let out Rush down, phlegm wet oedema, urine it is unfavorable etc..
Radix bupleuri: it is bitter, slightly cold, return liver, gallbladder channel, has the function of delivering and inner, rising Yang, liver of relaxing；Cure mainly cold, fever, fever and chills Contact, spleen deficiency chronic diarrhea, the vertical de-, rectal prolapse in uterus etc..
Dried orange peel: bitter, pungent, warm, returns spleen, lung channel have the function of regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm；It cures mainly poor appetite, let out It rushes down, abdominal pain, productive cough due to phlegm-damp etc..
Radix Astragali: sweet, warm, return lung, the spleen channel have the function of invigorating qi for strengthening superficies, pus draining and toxin expelling, miscarriage prevention；Cure mainly lumbago due to the kidney deficiency, waist Myasthenia of limbs, rheumatic arthralgia, threatened abortion etc..
Radix scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestinl channel, with heat-clearing and damp-drying drug, purging fire for removing toxin, miscarriage prevention, hemostasis function Energy；Cure mainly that cough with lung heat, stomach and intestine are damp and hot, dysentery, threatened abortion, jaundice, high fever phlegm retention, hematochezia, bleeding from five sense organs or subcutaneous tissue, red eye, swell pain, carbuncle swells Sore etc..
Schisandra chinensis: sour, sweet, warm, return lung, kidney, the heart channel of Hang-Shaoyin have the function of that the puckery intestines of astringing lung-QI, promote the production of body fluid hidroschesis；Cure mainly deficiency syndrome of the lung cough Asthma, chronic diarrhea, spontaneous perspiration, night sweat etc..
Rhizoma alismatis: it is sweet, cold, return bladder, kidney channel, have the function of excreting dampness expel the heat-evil, diuresis；Cure mainly diarrhea due to damp-heat, hematuria, sandstone Leaching, urination disorder, oedema etc..
Above all taste Chinese medicine is combined according to traditional Chinese medical theory compatibility, for the influence factor for influencing liver and kidney of livestock and poultry health, hair Wave the effect for the treatment of both manifestation and root cause of disease.
The beneficial effects of the present invention are: reasonable recipe, preparation is simple, mixes step by step more uniform；Chinese medicine composition is without dirt It contaminates, have no toxic side effect, no drug residue, having no drug resistance, at low cost, materials are wide, pulverize, bioavilability height, and curative effect is very aobvious It writes.The present invention preferably goes out the 13 taste Chinese medicine according to Chinese veterinarian's traditional theory, and them is made to form pure Chinese medicine according to optimum ratio Powder, clinical application prove there is special efficacy to promotion liver and kidney of livestock and poultry health, and its product is made to reach nuisanceless requirement, meets and produce The health of people has been effectively ensured in the export standard of product.
Specific embodiment
In conjunction with the preferred embodiment, to the specific embodiment provided according to the present invention, details are as follows:
Embodiment 1
A kind of pharmaceutical composition and preparation method thereof for livestock and poultry liver protection shield kidney: carry out as follows: (every part is pressed 10g meter)
(1) 700 meshes are crossed after pulverizing the various composition in prescription respectively；
(2) weigh by weight 150 parts of soybean lecithin, 100 parts of dandelion, 150 parts of dried orange peel, 100 parts of fructus lycii, 150 parts of radix paeoniae rubra, 150 parts of Radix Glycyrrhizae, 100 parts of rhizoma imperatae, mixing 5-10 minutes to uniform；
(3) 150 parts of lophatherum gracile, 150 parts of Poria cocos, 150 parts of radix bupleuri, 150 parts of Radix Astragali, 150 parts of radix scutellariae, the five tastes are weighed by weight Sub 150 parts, 150 parts of rhizoma alismatis, mixing 5-10 minutes is to uniform；
(4) merge above-mentioned (2), composition made from (3) step, continues to mix 10-15 minute to uniform.
Embodiment 2
A kind of pharmaceutical composition and preparation method thereof for livestock and poultry liver protection shield kidney: carry out as follows: (every part is pressed 10g meter)
(1) 700 meshes are crossed after pulverizing the various composition in prescription respectively；
(2) weigh by weight 400 parts of soybean lecithin, 200 parts of dandelion, 300 parts of dried orange peel, 150 parts of fructus lycii, 250 parts of radix paeoniae rubra, 250 parts of Radix Glycyrrhizae, 300 parts of rhizoma imperatae, mixing 5-10 minutes to uniform；
(3) 250 parts of lophatherum gracile, 300 parts of Poria cocos, 350 parts of radix bupleuri, 250 parts of Radix Astragali, 250 parts of radix scutellariae, the five tastes are weighed by weight Sub 300 parts, 250 parts of rhizoma alismatis, mixing 5-10 minutes is to uniform；
(4) merge above-mentioned (2), composition made from (3) step, continues to mix 10-15 minute to uniform.
Embodiment 3
A kind of pharmaceutical composition and preparation method thereof for livestock and poultry liver protection shield kidney: carry out as follows: (every part is pressed 10g meter)
(1) 700 meshes are crossed after pulverizing the various composition in prescription respectively；
(2) weigh by weight 650 parts of soybean lecithin, 300 parts of dandelion, 450 parts of dried orange peel, 200 parts of fructus lycii, 350 parts of radix paeoniae rubra, 350 parts of Radix Glycyrrhizae, 500 parts of rhizoma imperatae, mixing 5-10 minutes to uniform；
(3) 350 parts of lophatherum gracile, 450 parts of Poria cocos, 550 parts of radix bupleuri, 350 parts of Radix Astragali, 350 parts of radix scutellariae, the five tastes are weighed by weight Sub 450 parts, 350 parts of rhizoma alismatis, mixing 5-10 minutes is to uniform；
(4) merge above-mentioned (2), composition made from (3) step, continues to mix 10-15 minute to uniform.
Clinical test:
Clinical trial animal only selects the pig of 70-80 age in days, weight in 30kg-35kg to be tested.Selection is through laboratory Blood biochemical Testing and appraisal is sick pig 90 of lesions of liver and kidney, and health pig is 30.By 120 pig isolation individually raisings, feeding Complete feed, and by 90 sick pigs and it is randomly divided into 3 groups of (the respectively scattered group of illness blank control group, Duhuo jisheng and present invention Composition group), every group 30,3 groups of feeding environments are identical, and experimental period carries out 10 days altogether；Wherein healthy blank control group Without any processing with illness blank control group, drug control group (is detailed in " the Chinese people with institute's control drug " Duhuo jisheng dissipates " Republic's veterinary drug allusion quotation " 2000 editions two page 394) treatment is used according to an instruction；Present composition group can produce the present invention Product (composition obtained by the embodiment of the present invention 2) feeding, usage and dosage are as follows: this product press every 100g spice 200kg, daily 2~3 It is secondary.Achieve the purpose that kidney is protected in liver protection by gastrointestinal tract absorption after oral.After the test, 10 pigs, vein are randomly selected for every group Take a blood sample 10ml, separates serum, measures for blood parameters.
Judging index standard:
Glutamic-oxalacetic transaminease (AST) is one kind important in transaminase.It is the finger of liver function test on clinical medicine Mark, for judging whether liver is damaged.Glutamic-oxalacetic transaminease is primarily present in liver cell mitochondria, when liver occurs seriously When necrosis or destruction, it can just cause the significant raising of glutamic-oxalacetic transaminease.
Glutamic-pyruvic transaminase (ALT) is primarily present in liver, heart and skeletal muscle.Liver cell or certain tissue damages or bad Extremely, the glutamic-pyruvic transaminase in blood can all increased, raised degree is consistent with the degree that liver cell is damaged, therefore is mesh Preceding most common liver function index.
Creatinine (creatinine, Cre) is the product that muscle is metabolized in vivo, and mainly body is discharged by glomerular filtration in creatinine Outside.Clinically detection serum creatinine is common one of the main method for understanding renal function.Serum creatinine concentration variation mainly by The filtration ability (glomerular filtration rate) of glomerulus determines.The decline of filtration ability, then creatine concentration increases.Serum creatinine value is higher by Normal value majority means that compromised kidneys, serum creatinine accurate can react the substantially impaired situation of kidney,
Seralbumin (ALB) is synthesized in liver, is the most abundant protein of content in vertebrate blood plasma.It is being maintained Blood colloid osmotic pressure, the transport of cylinder metabolism-ure matter, nutrition etc. play critically important effect.It is usually examined when liver disease Serum albumin levels are surveyed to assist to diagnose.
Urea nitrogen (BUN) is one of renal function main indicator.So influence of the variation of urea nitrogen to nonprotein nitrogen numerical value It is larger.The detection of urea nitrogen is clinically often selected to replace the measurement of nonprotein nitrogen.Urea nitrogen is the master of body protein metabolism Want dead end product.Usual kidney is the major organs for draining urea, and urea can be inhaled after glomerular filtration in each section of tubule again It receives, in impaired renal function evil, the concentration of blood urea nitrogen is just increased rapidly.
The blood parameters testing result of table present composition group and other drugs to pig
It compiles Group AST(u/l) ALT ALB Cre BUN
Ⅰ Illness blank pair 122.13±1 1118.60± 22.30±1. 156.51±1.6 11.52±1.5
Ⅱ Healthy blank pair 71.27±1. 67.60±1 42.93±1. 92.62±1.09 4.92±1.26
Ⅲ Duhuo jisheng dissipates 78.50±1. 76.51±1 38.45±1. 98.35±1.35 5.25±1.62
Ⅳ Present invention combination 71.57±1. 67.50±1 48.65±1. 88.50±1.16 4.95±1.16
This object reality group tests result statistical analysis, and compared with healthy blank control group, items refer to present composition group Mark is close to normal index.Compared with Duhuo jisheng dissipates group, significant difference (the P < 0.05) in terms of AST, ALT, in ALB, Cre Be wanting in heteropolar significant (P < 0.01), dissipates group lower than Duhuo jisheng in terms of BUN, but difference is not significant (P > 0.05).Illustrate this Inventive composition group has significant ground liver protection shield kidney effect, and various aspects index dissipates group better than Duhuo jisheng, close to the normal blood of pig Biochemical indicator.
Safety testing:
20 age in days sodium selenite 30 is chosen, is raised according to 5 times of spices of the made composition recommended dose of the embodiment of the present invention 2 It feeds 10 days, during medication, piglet does not find the performance of any bad or abnormal behaviour, and feeding drinking-water is normal.
It is above-mentioned that the detailed of pharmaceutical composition of livestock and poultry liver protection shield kidney and preparation method thereof progress is used for this referring to embodiment Description, is illustrative without being restrictive, several embodiments can be enumerated according to limited range, therefore do not departing from Change and modification under present general inventive concept should belong within protection scope of the present invention.

Claims (2)

1. it is a kind of for livestock and poultry liver protection shield kidney pharmaceutical composition, it is characterized in that by following components mixed preparing in parts by weight and At: 15-65 parts of soybean lecithin, 10-30 parts of dandelion, 15-45 parts of dried orange peel, 10-20 parts of fructus lycii, 15-35 parts of radix paeoniae rubra, Radix Glycyrrhizae 15- 35 parts, 10-50 parts of rhizoma imperatae, 15-35 parts of lophatherum gracile, 15-45 parts of Poria cocos, 15-55 parts of radix bupleuri, 15-35 parts of Radix Astragali, radix scutellariae 15- 35 parts, 15-45 parts of Schisandra chinensis, 15-35 parts of rhizoma alismatis；
The preparation method of the pharmaceutical composition for livestock and poultry liver protection shield kidney is to carry out as follows:
(1) 700 meshes are crossed after pulverizing the various composition in prescription respectively；
(2) 15-65 parts of soybean lecithin, 10-30 parts of dandelion, 15-45 parts of dried orange peel, 10-20 parts of fructus lycii, radix paeoniae rubra are weighed by weight 15-35 parts, 15-35 parts of Radix Glycyrrhizae, 10-50 parts of rhizoma imperatae, mixing 5-10 minutes to uniform；
(3) 15-35 parts of lophatherum gracile, 15-45 parts of Poria cocos, 15-55 parts of radix bupleuri, 15-35 parts of Radix Astragali, radix scutellariae 15-35 are weighed by weight Part, 15-45 parts of Schisandra chinensis, 15-35 parts of rhizoma alismatis, mixing 5-10 minutes to uniform；
(4) merge above-mentioned (2), composition made from (3) step, continues to mix 10-15 minute to uniform.
2. the pharmaceutical composition according to claim 1 for livestock and poultry liver protection shield kidney, it is characterized in that the various components are excellent Match proportion are as follows: 40 parts of soybean lecithin, 20 parts of dandelion, 30 parts of dried orange peel, 15 parts of fructus lycii, 25 parts of radix paeoniae rubra, 25 parts of Radix Glycyrrhizae, rhizoma imperatae 30 parts, 25 parts of lophatherum gracile, 30 parts of Poria cocos, 35 parts of radix bupleuri, 25 parts of Radix Astragali, 25 parts of radix scutellariae, 30 parts of Schisandra chinensis, 25 parts of rhizoma alismatis.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1608649A (en) * 2003-10-17 2005-04-27 上海市中药研究所 Chinese medicine health tonic for raising antisenility capacity and improving memory
CN103977172A (en) * 2014-06-12 2014-08-13 山东鲁港福友药业有限公司 Medicinal composition and feed for treating liver and kidney diseases of chicken and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1608649A (en) * 2003-10-17 2005-04-27 上海市中药研究所 Chinese medicine health tonic for raising antisenility capacity and improving memory
CN103977172A (en) * 2014-06-12 2014-08-13 山东鲁港福友药业有限公司 Medicinal composition and feed for treating liver and kidney diseases of chicken and preparation method thereof

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