CN105358185B - 用于再生医学和组织工程的可生物降解的网络聚合物 - Google Patents

用于再生医学和组织工程的可生物降解的网络聚合物 Download PDF

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Publication number
CN105358185B
CN105358185B CN201480032915.9A CN201480032915A CN105358185B CN 105358185 B CN105358185 B CN 105358185B CN 201480032915 A CN201480032915 A CN 201480032915A CN 105358185 B CN105358185 B CN 105358185B
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China
Prior art keywords
polyether
monomer
chloride
biodegradable
network polymer
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Expired - Fee Related
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CN201480032915.9A
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English (en)
Chinese (zh)
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CN105358185A (zh
Inventor
安东·布伦科韦
贝尔卡伊·厄兹切利克
乔光华
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University of Melbourne
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University of Melbourne
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3324—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2371/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
    • C08J2371/08—Polyethers derived from hydroxy compounds or from their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/06—Biodegradable
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/16—Applications used for films

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201480032915.9A 2013-04-10 2014-04-10 用于再生医学和组织工程的可生物降解的网络聚合物 Expired - Fee Related CN105358185B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2013901223A AU2013901223A0 (en) 2013-04-10 Biodegradable network polymers for regenerative medicine and tissue engineering
AU2013901223 2013-04-10
PCT/AU2014/000391 WO2014165917A1 (en) 2013-04-10 2014-04-10 Biodegradable network polymers for regenerative medicine and tissue engineering

Publications (2)

Publication Number Publication Date
CN105358185A CN105358185A (zh) 2016-02-24
CN105358185B true CN105358185B (zh) 2019-08-06

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Country Status (7)

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US (2) US10179834B2 (enExample)
EP (1) EP2983726A4 (enExample)
JP (1) JP6403754B2 (enExample)
CN (1) CN105358185B (enExample)
AU (1) AU2014252769B2 (enExample)
BR (1) BR112015025904A2 (enExample)
WO (1) WO2014165917A1 (enExample)

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CN112870433B (zh) * 2021-01-18 2022-04-01 华东理工大学 DFO和rhBMP-2协同激发成骨的复合支架及其制备方法和应用
CN114181360A (zh) * 2021-12-08 2022-03-15 南京工业大学 一种超声波刺激响应聚氨酯及其制备方法
WO2025006821A2 (en) * 2023-06-30 2025-01-02 The University Of Melbourne Polymer compositions and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1446109A (zh) * 2000-08-04 2003-10-01 欧健有限公司 多孔人工移植骨及其制造方法

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US4110276A (en) * 1976-11-02 1978-08-29 The Procter & Gamble Company Polyester foam materials
JPS58160316A (ja) 1982-03-17 1983-09-22 Dai Ichi Kogyo Seiyaku Co Ltd 高分子量化合物の製造法
EP0696605B1 (de) * 1994-08-10 2000-09-20 Peter Neuenschwander Biokompatibles Blockcopolymer
GB9700508D0 (en) * 1997-01-11 1997-02-26 Smith & Nephew Hydrogels
JP2003274800A (ja) * 2002-03-22 2003-09-30 Daisee Kogyo Kk 疑似餌用生分解性素材
DE10240817A1 (de) 2002-08-30 2004-03-11 Basf Ag Verfahren zur Herstellung hyperverzweigter, wasserlöslicher Polyester
JP2004211008A (ja) * 2003-01-07 2004-07-29 Mitsubishi Chemicals Corp 生分解性共重合体とその製造方法
MXPA05008653A (es) 2003-02-14 2006-04-27 Depuy Spine Inc Dispositivo de fusion intervertebral formado in situ.
JP2007517543A (ja) 2003-11-20 2007-07-05 アンジオテック インターナショナル アーゲー ポリマー化合物とその使用法
US20090028957A1 (en) * 2005-04-19 2009-01-29 Daniloff George Y Implantable Tissue-Reactive Biomaterial Compositions and Systems, and Methods of Us Thereof
JP2007204614A (ja) * 2006-02-02 2007-08-16 Nisshin Oillio Group Ltd 樹脂用可塑剤及び該樹脂用可塑剤を含有する樹脂組成物
US8574311B2 (en) * 2008-05-07 2013-11-05 Board Of Regents, The University Of Texas System Versatile biodegradable elastic polymers featured with dual crosslinking mechanism for biomedical applications
US20120178824A1 (en) 2011-01-11 2012-07-12 Henkel Ag & Co. Kgaa Hydrogels based on esters of polyisobutenesuccinic acid

Patent Citations (1)

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CN1446109A (zh) * 2000-08-04 2003-10-01 欧健有限公司 多孔人工移植骨及其制造方法

Non-Patent Citations (1)

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Title
Ultrathin chitosan-poly(ethylene glycol) hydrogel films for corneal tissue engineering;Berkay Ozcelik et al;《Acta Biomaterialia》;20130129;第9卷(第5期);6594-6605 *

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Publication number Publication date
AU2014252769A1 (en) 2015-11-26
EP2983726A4 (en) 2016-12-14
US20160060392A1 (en) 2016-03-03
EP2983726A1 (en) 2016-02-17
CN105358185A (zh) 2016-02-24
WO2014165917A1 (en) 2014-10-16
US20190194389A1 (en) 2019-06-27
JP6403754B2 (ja) 2018-10-10
AU2014252769B2 (en) 2017-11-30
JP2016518485A (ja) 2016-06-23
BR112015025904A2 (pt) 2017-07-25
US10179834B2 (en) 2019-01-15

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Inventor after: Anton Brenkovi

Inventor after: Belkay Ezchelick

Inventor after: Qiao Guanghua

Inventor before: Anton Brenkovi

Inventor before: Belkay Ezchelick

Inventor before: Qiao Greg Guang Hua

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Granted publication date: 20190806