CN105358159B - 用于细胞动员中的硫酸葡聚糖 - Google Patents

用于细胞动员中的硫酸葡聚糖 Download PDF

Info

Publication number
CN105358159B
CN105358159B CN201480038833.5A CN201480038833A CN105358159B CN 105358159 B CN105358159 B CN 105358159B CN 201480038833 A CN201480038833 A CN 201480038833A CN 105358159 B CN105358159 B CN 105358159B
Authority
CN
China
Prior art keywords
dextran sulfate
cell
csf
cells
mobilization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201480038833.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN105358159A (zh
Inventor
A·瓦斯
I·杜普来
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TX Medic AB
Original Assignee
TX Medic AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TX Medic AB filed Critical TX Medic AB
Publication of CN105358159A publication Critical patent/CN105358159A/zh
Application granted granted Critical
Publication of CN105358159B publication Critical patent/CN105358159B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1833—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201480038833.5A 2013-05-13 2014-05-12 用于细胞动员中的硫酸葡聚糖 Active CN105358159B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1350584A SE537742C2 (sv) 2013-05-13 2013-05-13 Dextransulfat för cellmobilisering
SE1350584-7 2013-05-13
PCT/SE2014/050576 WO2014185851A1 (en) 2013-05-13 2014-05-12 Dextran sulfate for use in mobilization of cells

Publications (2)

Publication Number Publication Date
CN105358159A CN105358159A (zh) 2016-02-24
CN105358159B true CN105358159B (zh) 2018-08-28

Family

ID=51898693

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480038833.5A Active CN105358159B (zh) 2013-05-13 2014-05-12 用于细胞动员中的硫酸葡聚糖

Country Status (10)

Country Link
US (1) US10258642B2 (enExample)
EP (1) EP2999478B1 (enExample)
JP (1) JP6339668B2 (enExample)
CN (1) CN105358159B (enExample)
CA (1) CA2912366C (enExample)
DK (1) DK2999478T3 (enExample)
ES (1) ES2780907T3 (enExample)
PL (1) PL2999478T3 (enExample)
SE (1) SE537742C2 (enExample)
WO (1) WO2014185851A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201408233D0 (en) 2014-05-09 2014-06-25 Austrianova Singapore Pte Ltd Use of polyanionic composition
SE538503C2 (en) 2014-11-11 2016-08-16 Tx Medic Ab New dextran sulfate
RU2623152C9 (ru) * 2015-10-15 2022-02-17 Акционерное общество "Федеральный научно-производственный центр "Алтай" Композиция, обладающая гепатопротекторными и иммуностимулирующими свойствами
CN114127262A (zh) * 2019-05-16 2022-03-01 香港中文大学 细胞外基质材料及其用途
SE544015C2 (en) * 2019-06-18 2021-11-02 Tx Medic Ab Allogenic car-t cell therapy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3454560A (en) 1966-03-01 1969-07-08 Seikagaku Kogyo Co Ltd Process for the production of chondroitin polysulfate
SE525461C3 (sv) 2002-11-28 2005-03-23 Prophymed Ab Ny användning av dextransulfat
CN1589904A (zh) 2003-09-01 2005-03-09 北京大学 造血干细胞动员剂制备治疗糖尿病药物的用途

Also Published As

Publication number Publication date
US10258642B2 (en) 2019-04-16
EP2999478A4 (en) 2017-02-22
CN105358159A (zh) 2016-02-24
US20160120897A1 (en) 2016-05-05
SE1350584A1 (sv) 2014-11-14
CA2912366C (en) 2021-04-06
BR112015028270A2 (pt) 2017-07-25
CA2912366A1 (en) 2014-11-20
JP6339668B2 (ja) 2018-06-06
DK2999478T3 (da) 2020-04-14
JP2016519143A (ja) 2016-06-30
EP2999478A1 (en) 2016-03-30
EP2999478B1 (en) 2020-01-15
PL2999478T3 (pl) 2020-10-19
SE537742C2 (sv) 2015-10-13
WO2014185851A1 (en) 2014-11-20
ES2780907T3 (es) 2020-08-27

Similar Documents

Publication Publication Date Title
EP2324109B1 (en) Expansion of haemopoietic precursors
CN105358159B (zh) 用于细胞动员中的硫酸葡聚糖
WO2004104166A2 (en) Administration of hyaluronic acid to enhance the function of transplanted stem cells
US20140294755A1 (en) Materials and Methods Relating to Stem Cell Mobilization by Multi-Pegylated Granulocyte Colony Stimulating Factor
EP0831888B1 (en) Methods for increasing hematopoietic cells
RU2351357C2 (ru) Фармацевтическая композиция, используемая для мобилизации стволовых клеток
US20210186999A1 (en) Method for treatment of cancer
EP2384760A1 (en) Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells
EP1641431B1 (en) Uses of il-12 for reducing the toxicity of chemo- and/or radio-therapy
EP3823660A1 (en) Periostin compounds for the treatment of haematological complications
US10918695B2 (en) Use of jack bean lectin for increasing the abundance of hematopoietic stem cells and progenitor cells in bone marrow and/or epidermal stem cells in skin in vivo
TW201121965A (en) Use of a quinolone derivative containing 7-(4-aminomethyl-3-oxime)pyrrolidine group that is capable of inducing granulocyte colony stimulating factor for treatment of neutropenia and recovery of hematopoiesis
BR112015028270B1 (pt) Composição de mobilização de células para uso na mobilização de células progenitoras e/ou células tronco
US20210338713A1 (en) Reduction of Pulmonary Inflammation Using Therapeutic Gas Mixtures
JP2006342131A (ja) 白血球及び／又は造血幹・前駆細胞動員剤
KR101659846B1 (ko) Har-nds 유래 조혈줄기세포, 그 분리방법 및 용도
JP2024517954A (ja) 肝疾患を治療するための方法および組成物
Rzepecki et al. Sources of hematopoietic stem cells
US8546353B2 (en) Compounds and combinations

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant