CN105343166A - Traditional Chinese medicinal composition and application thereof in cosmetics - Google Patents
Traditional Chinese medicinal composition and application thereof in cosmetics Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The invention discloses a traditional Chinese medicinal composition and application thereof in cosmetics. The traditional Chinese medicinal composition consists of the following raw materials in parts by weight: 30-45 parts of ligusticum wallichii, 30-45 parts of sargentgloryvine stem, 30-45 parts of radix sophorae flavescentis, 20-35 parts of spina gleditsiae, 10-25 parts of fructus kochiae and 10-25 parts of peppermint. The traditional Chinese medicinal composition provided by the invention has functions of activating blood and dredging collaterals, resisting fungi and promoting skin absorption; the traditional Chinese medicinal composition is capable of recovering nutrition supply to skin and recovering the normal metabolism of the skin; and the traditional Chinese medicinal composition can be used for preventing, improving or eliminating calluses. The traditional Chinese medicinal composition, as an active ingredient, can be directly added to the cosmetics; and the traditional Chinese medicinal composition is simple in process and suitable for industrial production.
Description
Technical field
The present invention relates to cosmetic field, particularly relate to a kind of Chinese medicine composition and the application in cosmetics thereof.
Background technology
Callus is the infringement of limitation flat hyperkeratosis, and the callus in vola is commonly called as callosity.The multiple position being born in long-term pressurized and friction of callus, as the palm, the sole of the foot give prominence to position, also shows in other pressurized positions.Infringement is for local skin cutin hyperkeratosis, and in flat or mound shape protuberance, central authorities are thicker, and edge is thinner, obscure boundary; In faint yellow or wax yellow, translucent, smooth surface, that touches is hard.Local sweat secretion reduces, insensitive, or has and slightly press pain.Its cause of disease traditional Chinese medical science thinks that the QI-blood circulation that brothers cause by rubbing, oppressing for a long time is smooth, and failure of skin and muscle to be nourished forms.
The cell infiltration that fungal infection causes also can cause cutin hyperkeratosis and cause the generation of callus, and blocked up horny layer can stop drug osmotic to arrive focus, and causes the vicious cycle that the blocked up fungus of the thickening then horny layer of fungal infection horny layer is not easily killed.
For above-mentioned reasons, eliminating callus not only needs to recover the supply of skin normal nutrition, recover skin homergy, also needs to kill the fungus under callus.Therefore, improving the infiltration of cosmetic actives to skin is problem demanding prompt solution.
Realizing finding in process of the present invention, the removing callus product on market is distinguished by its mechanism of action can be divided into two classes substantially:
One, physics class: the frosted product on market and pedicure knife can be classified as this type of.Frosted product, mainly by some fine granularity material massaging skin, is removed the old cutin on skin, is made pachylosis, hydropenia, stiff phenomenon is improved.But the factors such as massage force is excessive, frosted granule is really up to the mark, frosted grain edges is too sharp-pointed horny layer can be made to polish excessively thin, even scratch mark, impels skin keratin protectiveness hypertrophy.Pedicure service on market mainly uses pedicure knife to cut lower callus part, and because the technology of operator is uneven, pedicure easily hurts corium, causes infection.
Two, chemical classes: the product containing fruit acid, salicylic acid, Fructus Chaenomelis ferment, sulfur etc. belongs to chemolysis class, can soften cuticle, be adsorbed on the horn cell on top layer, the constitute dissolved between cutin makes it come off, the action intensity of exfoliation depends on the height of these chemical concentration, has the consumer of significant proportion to this type of allergies, feels zest, even cause a skin inflammation, can not life-time service.The medication cycle is longer, and in medication process, callus can turn white exsiccation, larger to appearance effects.Removing callus need use during fruit acid or the salicylic acid of higher concentration and must carry out, in order to avoid misoperation burned skin under professional instructs.
Realizing in process of the present invention, finding that in prior art, at least there are the following problems:
1, safety issue, easily causes zest injury, anaphylaxis injury, infectious injury;
2, easily excessively remove cutin, infringement skin barrier, makes the easy hydropenia of skin, sensitivity and aging, easily impels cutin protectiveness hypertrophy;
3, larger on skin appearance impact during processing callus;
4, not easy to operate, need carry out under professional instructs;
5, cure the symptoms, not the disease, easily recur.
Therefore, provide a kind of use safety, effect significantly, can the removing callus cosmetics of Transdermal absorption be that market expected.
Summary of the invention
For the problems referred to above, the object of this invention is to provide a kind of Chinese medicine composition and the application in cosmetics thereof.Described Chinese medicine composition has the supply of recovery skin normal nutrition, recovers skin homergy, antifungal effect, and transdermal absorption factor is high, low to skin irritation, be added into technique in cosmetics simple, the effect to callus, there is prevention, improving or eliminate.
The object of the invention is to be achieved through the following technical solutions:
The object of the present invention is to provide a kind of Chinese medicine composition, described Chinese medicine composition is made up of the raw material of following weight parts:
Rhizoma Chuanxiong 30-45 part, Caulis Sargentodoxae 30-45 part, Radix Sophorae Flavescentis 30-45 part, Spina Gleditsiae 20-35 part, Fructus Kochiae 10-25 part, Herba Menthae 10-25 part.
Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong, and it is warm in nature, acrid in the mouth, micro-hardship, has blood-activating and qi-promoting, goes effect of wind pain relieving.Blood viscosity can be effectively reduced and expand blood vessel, to the rheological characteristic of blood, there is good improvement effect.
One of them performance of invigorating blood circulation is the quickening of microcirculqtory system, and blood capillary diastole, blood capillary crossing net increase the object accelerating with velocity of blood flow all can realize invigorating blood circulation.Micro-circulation speed is accelerated, keratinocyte etc. for skin provides sufficient oxygen and nutrient substance, and the metabolite of cell and various harmful substance is removed in time, the old cell of metabolism, reduce the oxidation of collagen fiber, and make the various cells of skin maintain good function.
Radix Sophorae Flavescentis is the dry root of leguminous plant Radix Sophorae Flavescentis, has effect of heat clearing and damp drying, parasite killing, diuresis.There is stronger resisting pathogenic microbes, antiinflammatory and antiallergic activity.Impel growth and the reparation of impaired nervus vasculairs cell, recover subcutaneous capillary cell viability.
Caulis Sargentodoxae is Saggentodoxa fallen leaves woody climber Caulis Sargentodoxae, has effect of heat-clearing and toxic substances removing, vital energy regualting and blood circulation-promoting, dispersing swelling and dissipating binds, the meridian dredging, is used for the treatment of amenorrhea dysmenorrhea, rheumatic arthralgia, treating swelling and pain by traumatic injury etc.Pharmaceutical research shows that Caulis Sargentodoxae has antibacterial, the effect such as antiinflammatory, anticoagulant.
Spina Gleditsiae is the dry Spina jujubae of leguminous plant Fructus Gleditsia, has the effect of detumescence poison holding, evacuation of pus, parasite killing.Modern pharmacological research shows, Spina Gleditsiae has antibacterial, the effect such as antiinflammatory, anticoagulation.It is comparatively strong that it attacks loose power, can take medicine and to go directly disease institute.
The Fructus Kochiae is the dry mature fruit of chenopod Fructus Kochiae, the effect such as have clearing away heat-damp and promoting diuresis, go wind antipruritic.Modern pharmacological research shows, the Fructus Kochiae have antibacterial, kill demodicid mite, the anti-effect such as to scratch where it itches.It is rich in retinoid material, can promote normal epidermis cell proliferation, makes hyperplasia epidermis normalization.
Herba Menthae is the ground drying nest of labiate Herba Menthae, has the effect of loose wind heat, refresh oneself, rash.Herba Menthae gram increases the absorbance of medicine, has facilitation to the Transdermal absorption of medicine.
In the present invention, Six-element medicine share with special ratios, the effect playing promoting blood circulation to remove obstruction in the collateral, antibacterial anti-inflammatory, the absorption of promotion skin can be worked in coordination with, skin-nourishing supply can be recovered, recover skin eubolism, can prevent, improve or eliminate because qi depression to blood stasis, QI-blood circulation are obstructed and are caused limitation flat hyperkeratosis to be damaged, can prevent, improve or eliminate simultaneously the limitation flat hyperkeratosis infringement because fungal infection causes.
In certain embodiments, described Chinese medicine composition is made up of the raw material of following weight parts:
Rhizoma Chuanxiong 35-40 part, Caulis Sargentodoxae 35-40 part, Radix Sophorae Flavescentis 35-40 part, Spina Gleditsiae 25-30 part, Fructus Kochiae 15-20 part, Herba Menthae 15-20 part.
In certain embodiments, described Chinese medicine composition is the extract of 50-70% ethanol water.
Utilize various composition deliquescent difference in the solvent of opposed polarity in plant, use solvent to be dissolved out in plant tissue by effective ingredient.Above-mentioned ethanol water can not play chemical change with plant component, price economy, be easy to get, low to skin irritation, be easy to recycle.Ethanol not only uses as solvent, and ethanol also has the function of cold removing of invigorating blood circulation, sterilization convergence.Ethanol can infiltrate expansion horny layer and soften cuticle, strengthens the gap between cutin, improves some percutaneous penetration of drugs speed, and greatly can improve mechanism with Herba Menthae composition compound penetrating agent.
Another object of the present invention is to provide the application of a kind of Chinese medicine composition of the present invention in cosmetics.
In certain embodiments, described Chinese medicine composition as prevention, improve or eliminate the effective ingredient of callus and add in cosmetics.
The invention provides a kind of cosmetics, described toiletry bag is containing the Chinese medicine composition of percetage by weight 10-50% of the present invention, and surplus is the carrier and combination thereof that allow in cosmetics.
Above-mentioned Chinese medicine composition proves through long-term experiment, low to skin irritation, can be used as effective ingredient and directly adds in cosmetics.
Carrier in cosmetics can enumerate excipient, filming agent, bonding agent, extender, disintegrating agent, stabilizing agent, antioxidant, lubricant, diluent, dispersant, buffer agent, osmotic pressure regulator, pH adjusting agent, emulsifying agent, antiseptic, surfactant, coloring agent, UV absorbent, wetting agent, thickening agent, active reinforcing agent, anti-inflammatory agent, antibacterial, spice, correctives, flavoring agent etc.
A kind of Chinese medicine composition provided by the invention and the application in cosmetics thereof have the following advantages and beneficial effect:
1, Chinese medicine composition provided by the invention has promoting blood circulation to remove obstruction in the collateral, promotes effect that skin absorbs, and can recover skin-nourishing supply, recover skin eubolism, effectively can prevent, improve or eliminate callus.
2, the skin absorptance of Chinese medicine composition provided by the invention is high, and effective ingredient can go directly fungal infection place.
3, Chinese medicine composition provided by the invention has significant antifungal efficacy, can prevent to infiltrate the callus that causes generate because fungal infection causes inflammation.
4, Chinese medicine composition provided by the invention directly can apply callus place, can be used as effective ingredient and add in cosmetics, can also water directly in replacement cosmetic product formula, and technique is simple, easy to use, little to skin irritation.
Detailed description of the invention
Below with reference to specific embodiment, the present invention will be further described.
Embodiment 1
By Rhizoma Chuanxiong 300g, Caulis Sargentodoxae 450g, Radix Sophorae Flavescentis 300g, Spina Gleditsiae 350g, after Fructus Kochiae 100g, Herba Menthae 250g are crushed to respectively and can cross 30 mesh sieves, mixing, obtain Traditional Chinese drug mixture, add 60% ethanol water of Traditional Chinese drug mixture quality 6 times, in 40 DEG C of lixiviates 24 hours, filter, reclaim filtrate and obtain Chinese medicine composition A1.
Embodiment 2
By Rhizoma Chuanxiong 350g, Caulis Sargentodoxae 400g, Radix Sophorae Flavescentis 350g, Spina Gleditsiae 300g, after Fructus Kochiae 150g, Herba Menthae 200g are crushed to respectively and can cross 30 mesh sieves, mixing, obtain Traditional Chinese drug mixture, add 60% ethanol water of Traditional Chinese drug mixture quality 6 times, in 40 DEG C of lixiviates 24 hours, filter, reclaim filtrate and obtain Chinese medicine composition A2.
Embodiment 3
By Rhizoma Chuanxiong 375g, Caulis Sargentodoxae 375g, Radix Sophorae Flavescentis 375g, Spina Gleditsiae 275g, after Fructus Kochiae 175g, Herba Menthae 175g are crushed to respectively and can cross 30 mesh sieves, mixing, obtain Traditional Chinese drug mixture, add 60% ethanol water of Traditional Chinese drug mixture quality 6 times, in 40 DEG C of lixiviates 24 hours, filter, reclaim filtrate and obtain Chinese medicine composition A3.
Embodiment 4
By Rhizoma Chuanxiong 400g, Caulis Sargentodoxae 350g, Radix Sophorae Flavescentis 400g, Spina Gleditsiae 250g, after Fructus Kochiae 200g, Herba Menthae 150g are crushed to respectively and can cross 30 mesh sieves, mixing, obtain Traditional Chinese drug mixture, add 60% ethanol water of Traditional Chinese drug mixture quality 6 times, in 40 DEG C of lixiviates 24 hours, filter, reclaim filtrate and obtain Chinese medicine composition A4.
Embodiment 5
By Rhizoma Chuanxiong 450g, Caulis Sargentodoxae 300g, Radix Sophorae Flavescentis 450g, Spina Gleditsiae 200g, after Fructus Kochiae 250g, Herba Menthae 100g are crushed to respectively and can cross 30 mesh sieves, mixing, obtain Traditional Chinese drug mixture, add 60% ethanol water of Traditional Chinese drug mixture quality 6 times, in 40 DEG C of lixiviates 24 hours, filter, reclaim filtrate and obtain Chinese medicine composition A5.
Embodiment 6
By Rhizoma Chuanxiong 375g, Caulis Sargentodoxae 375g, Radix Sophorae Flavescentis 375g, Spina Gleditsiae 275g, after Fructus Kochiae 175g, Herba Menthae 175g are crushed to respectively and can cross 30 mesh sieves, mixing, obtain Traditional Chinese drug mixture, add 50% ethanol water of Traditional Chinese drug mixture quality 6 times, in 40 DEG C of lixiviates 24 hours, filter, reclaim filtrate and obtain Chinese medicine composition A6.
Embodiment 7
By Rhizoma Chuanxiong 375g, Caulis Sargentodoxae 375g, Radix Sophorae Flavescentis 375g, Spina Gleditsiae 275g, after Fructus Kochiae 175g, Herba Menthae 175g are crushed to respectively and can cross 30 mesh sieves, mixing, obtain Traditional Chinese drug mixture, add 70% ethanol water of Traditional Chinese drug mixture quality 6 times, in 40 DEG C of lixiviates 24 hours, filter, reclaim filtrate and obtain Chinese medicine composition A7.
Comparative example 1
By Rhizoma Chuanxiong 250g, Caulis Sargentodoxae 500g, Radix Sophorae Flavescentis 250g, Spina Gleditsiae 400g, after Fructus Kochiae 50g, Herba Menthae 300g are crushed to respectively and can cross 30 mesh sieves, mixing, obtain Traditional Chinese drug mixture, add 60% ethanol water of Traditional Chinese drug mixture quality 6 times, in 40 DEG C of lixiviates 24 hours, filter, reclaim filtrate and obtain Chinese medicine composition B1.
Comparative example 2
By Rhizoma Chuanxiong 500g, Caulis Sargentodoxae 250g, Radix Sophorae Flavescentis 500g, Spina Gleditsiae 150g, after Fructus Kochiae 300g, Herba Menthae 50g are crushed to respectively and can cross 30 mesh sieves, mixing, obtain Traditional Chinese drug mixture, add 60% ethanol water of Traditional Chinese drug mixture quality 6 times, in 40 DEG C of lixiviates 24 hours, filter, reclaim filtrate and obtain Chinese medicine composition B2.
Comparative example 3
By Rhizoma Chuanxiong 375g, Caulis Sargentodoxae 375g, Radix Sophorae Flavescentis 375g, Spina Gleditsiae 275g, after Fructus Kochiae 175g, Herba Menthae 175g are crushed to respectively and can cross 30 mesh sieves, mixing, obtain Traditional Chinese drug mixture, add 40% ethanol water of Traditional Chinese drug mixture quality 6 times, in 40 DEG C of lixiviates 24 hours, filter, reclaim filtrate and obtain Chinese medicine composition B3.
Comparative example 4
By Rhizoma Chuanxiong 375g, Caulis Sargentodoxae 375g, Radix Sophorae Flavescentis 375g, Spina Gleditsiae 275g, after Fructus Kochiae 175g, Herba Menthae 175g are crushed to respectively and can cross 30 mesh sieves, mixing, obtain Traditional Chinese drug mixture, add 80% ethanol water of Traditional Chinese drug mixture quality 6 times, in 40 DEG C of lixiviates 24 hours, filter, reclaim filtrate and obtain Chinese medicine composition B4.
Embodiment 8 permeates efficacy validation
(1) laboratory sample: embodiment 1-7 and comparative example 1-4 gained Chinese medicine composition are release liquid.
(2) laboratory animal: the adult mice of health, skin zero damage, regular grade, totally 11, body weight is 20 ± 2g, is provided (animal productiong credit number: SCXK (river) 2001-0011) by Sichuan Province's medical experiment Institute of Botany, the experimental animal quality certification is numbered: 2001A032, the temperature of Animal House is 23 DEG C, and humidity is 52%RH, and drinking water is tap water, carry out random packet before experiment, often organize 10; Test prospective adaptation raises 7 days, feed of freely drinking water.
(3) experiment reagent and equipment
Franz diffusion cell PermeGear, purchased from Shanghai Yu Yan scientific instrument company limited.
HPLC, purchased from Guangzhou Féraud door scientific instrument company limited.Chromatographic column is HypersilBDSC
38post (250mm × 4.6mm, 5 μm).
Acceptable solution: normal saline, purchased from Guangzhou Wei Jia Science and Technology Ltd..
(4) experimental procedure
1, the preparation of isolated skin: cut off hair except mouse web portion with the electronic hair that pushes away, put to death by mice cervical dislocation, take off harmless skin of abdomen, remove subcutaneous fat and adhesion thing, normal saline is rinsed well repeatedly, puts-20 DEG C and saves backup;
2, get above-mentioned Corium Mus, naturally thaw under room temperature, clean, blot skin surface moisture with filter paper with normal saline, the skin corium of skin is towards receiving chamber, and release liquid consumption is lmL, and reception tank volume is 16mL, and diffusion area is 1cm
2, test temperature is 37 ± 0.5 DEG C, and magnetic agitation rotating speed is 400r/min, starts test after pre-equilibration 30min, in 0.5,1,2,4,8,12,24h takes out 1mL from sample receiving chamber, add 1mL normal saline simultaneously.
3, by take out acceptable solution sample through 0.45 μm of filtering with microporous membrane, for HPLC sample introduction analyze, in 240nm wavelength place measure trap, flow velocity is 1.0mL/min, circulation be 60% methanol aqueous solution mutually, sample size is 20 μ L, column temperature 35 DEG C.Determine the drug level of each sample time;
(5) experimental result process: the accumulation transdermal amount Q of unit of account area medicine as follows
n
C in formula
nbe n-th sample, C
ibe the measured concentration of i-th sample, V
0for the volume of solution in receiving chamber, V
ifor each sample volume, A is skin diffusion area.
(6) experimental result
The accumulation transdermal amount of table 1 Chinese medicine composition
(7) interpretation of result: as shown in Table 1, Chinese medicine composition A1-7 and B1-4 can Transdermal absorption.Learn from A1-4 results contrast, the osmotic efficiency of medicine is directly proportional to the consumption of penetrating agent Herba Menthae; Wherein the osmotic efficiency of A1 is the highest, and compared with the A1 B1 larger with Herba Menthae consumption, its osmotic efficiency does not have significant change, and describing the raising of Herba Menthae to cutaneous permeability is not unrestrictedly along with concentration increases.The distinctive points of the preparation method of A3, A6, A7, B3, B4 is only that the content of the ethanol of ethanol water is different, it is compared and learns, in the scope that ethanol content is 40-70%, the permeability of skin improves with ethanol content and raises, describing one is that ethanol can promote cutaneous permeability, and two is that ethanol content improves the stripping that can increase effective ingredient in Chinese medicine; But the facilitation effect of B4 is far below other, describes too high ethanol content and the protein denaturation on skin can be caused to form fine and close film at skin surface, hinder the infiltration of ingredient.
Embodiment 9 is invigorated blood circulation efficacy validation
(1) test specimen: according to the Chinese medicine composition that embodiment 1-7 and comparative example 1-4 is obtained, be divided into tested material a1, a2, a3, a4, a5, a6, a7, b1, b2, b3, b4 with after normal saline dilution 5 times respectively; Embodiment 1-7 gained Chinese medicine composition dilutes to obtain a1-7 respectively, and the Chinese medicine composition B1-4 of comparative example 1-4 gained dilutes to obtain b1-4 respectively, take normal saline as blank reagent;
(2) experimental animal: the adult mice of health, skin zero damage, regular grade, totally 120, body weight is 20 ± 2g, is provided (animal productiong credit number: SCXK (river) 2001-0011) by Sichuan Province's medical experiment Institute of Botany, the experimental animal quality certification is numbered: 2001A032, the temperature of Animal House is 23 DEG C, and humidity is 52%RH, and drinking water is tap water, carry out random packet before experiment, often organize 10; Test prospective adaptation raises 7 days, feed of freely drinking water.
(3) test reagent and instrument:
Urethane, purchased from Sichuan Ke Long chemical reagent factory.
Normal saline, purchased from Cologne, Sichuan pharmaceutcal corporation, Ltd.
Microscope MoticBA300 and Moticimageadvanced3.2 work station, Microcirculation observation platform.
(4) test procedure:
1. 11 groups of mices use different tested material 0.5mL gavage respectively, and 1 group of mice is as blank group 0.5mL normal saline gavage, and every day, gavage twice, separated 8 hours during twice gavage at least, continuous gastric infusion 8 days, feed of freely drinking water.
2. the fine hair that front Medical adhesive plaster pastes mice two ear is tested, warm water cleaning.
3. after last administration, use urethane to carry out intraperitoneal anesthesia, back of the body position is fixed on observation platform, makes auricle open and flat in ear holder, drips a little liquid paraffin at Er Tuo and auricle surface.
4. be placed in the change upon administration of cold light source basis of microscopic observation Mice Auricle microcirculation, record after last administration 10 respectively, 20,30min auricle capillary open amount, use blood capillary Point of intersection count method to measure capillary open amount.
(5) experimental result
The open number of variations of table 2 Mice Auricle blood capillary crossing net
(6) interpretation of result:
From table 2, after administration 10,20,30min, compare with blank group, the open number of Mice Auricle blood capillary crossing net of each tested material effect is significantly increased.Point out Chinese medicine composition of the present invention to improve significantly to Mice Auricle microcirculation, there is the effect of invigorating blood circulation.Wherein tested material a1-5, b1 with b2 result are compared and are learnt, all have effect of significantly invigorating blood circulation, and its difference is little, and the impact of difference on its performance of invigorating blood circulation describing its proportioning raw materials is little.Wherein tested material a3, a6, a7, b3, b4 result are compared and are learnt, its performance of invigorating blood circulation is the highest when 60% ethanol water, successively decrease along with the rising of concentration of alcohol and reduction, when concentration of alcohol be elevated to 80% and be reduced to 40% time, its performance of invigorating blood circulation is relatively not remarkable.
Embodiment 10 antifungal efficacy is verified
(1) test specimen: according to the Chinese medicine composition that embodiment 1-7 and comparative example 1-4 is obtained, be divided into tested material c1, c2, c3, c4, c5, c6, c7, d1, d2, d3, d4 with after normal saline dilution 2 times respectively; Embodiment 1-7 gained Chinese medicine composition A1-7 dilutes to obtain c1-7 respectively, and the Chinese medicine composition B1-4 of comparative example 1-4 gained dilutes to obtain d1-4 respectively.
(2) test reagent and instrument:
Normal saline, purchased from Cologne, Sichuan pharmaceutcal corporation, Ltd.
Trichophyton, purchased from Nanjing institute of internal medicine of Chinese Academy of Sciences medical mycology bunker.
Husky guarantor's agar culture medium, purchased from Cologne, Sichuan pharmaceutcal corporation, Ltd.
Biochemical cultivation case, purchased from Guangzhou Shi Yang cleaning equipment company limited.
Rustless steel high-pressure steam sterilizing pan, purchased from Guangzhou Shi Yang cleaning equipment company limited.
(4) test procedure:
1. husky agar culture medium of protecting is used to manufacture test tube slant culture medium, the examination strain that supplies after activation is accessed test tube slant culture medium culturing, be placed in 28 DEG C of calorstats and cultivate 48h, get a little thalline in the test tube that physiological saline solution is housed respectively with inoculating loop, concussion evenly makes bacteria suspension.Measure the cell concentration of bacterium liquid by flat-plate bacterial colony method, and to be diluted to thalline number be 10
4/ mL.
2. solid medium heat fused is cooled to 50 DEG C, experimental group is got 1mL tested material respectively and is joined in 20mL solid medium and mix, matched group is got 1mL physiological saline solution and is joined in 20mL solid medium and mix, and then joins in the sterile petri dish of D9cm respectively, places 24 hours.
3. on each experimental group, matched group culture dish, be coated with 0.2mL bacterium liquid respectively, in 28 DEG C of calorstats, cultivate 72h, colony count in every 24 hours observed and recorded culture dishs, calculates its sterilizing rate.
4. sterilizing rate=(matched group colony count-experimental group colony count)/matched group colony count × 100%
(5) experimental result
The sterilizing rate of table 3 Chinese medicine composition
(6) interpretation of result:
From table 3, cultivate after 72 hours, each tested material all has significant antibacterial activity to trichophyton.Wherein tested material a1-5, b1 with b2 result are compared and are learnt, all have obvious antibacterial effect, and wherein the antibacterial activity of b1, b2 is poor, and the raw material describing the specific proportioning of Chinese medicine composition A1-5 has the effect of Synergistic.Wherein tested material a3, a6, a7, b3, b4 result are compared and are learnt, its anti-microbial property is the highest when 60% ethanol water, successively decrease along with the rising of concentration of alcohol and reduction, when concentration of alcohol be elevated to 80% and be reduced to 40% time, its anti-microbial property is relatively not remarkable.
Embodiment 11
Chinese medicine composition A3 embodiment 3 provided is that effective ingredient makes removing callus emulsion, is divided into D1, D2, D3, D4, D5 by different effective ingredient concentration, and blank is the emulsion containing same excipient not containing Chinese medicine composition.
The each weight percentages of components of table 4 removing callus emulsion and preparation process catalog
Embodiment 12 efficacy assessments
(1) experiment purpose
Evaluated by relative analysis, the removing callus emulsion obtained by Evaluation operation example 11 is improved or is eliminated the effect of callus.
(2) experimental technique
Collection wears high-heel shoes for a long time, and have women 180 people of callus and talalgia symptom in various degree, be divided into 6 groups at random, often organize 30 people, 36.4 years old mean age, experimenter is healthy, without hereditary or passing medical history, without bad life habits etc.Carry out observation of curative effect for embodiment 11 gained removing callus emulsion, observe trier and improve situation in pilot region callus place before testing and in test process.
In the left and right sides, experimenter's sole callus affected part, effect is improved as test zone test callus place in the region of selected about 5 × 5cm size, and use removing callus emulsion to smear, applying amount is about 5g, sooner or later respectively once, uses 8 weeks continuously.
Use removing callus emulsion to smear at experimenter's heel place, applying amount is about 5g, sooner or later respectively once uses 8 weeks continuously, to test its improvement situation to talalgia.
(3) evaluation methodology
Trier's callus improves the Standardization of diagnosis and curative effect of degree with reference to traditional Chinese medical science callus.Cure: callus disappears completely; Take a turn for the better: callus deliquescing is thinning.
(4) experimental result
Table 5 is tried out removing callus emulsion and is improved situation to callus
Table 6 is tried out removing callus emulsion and is improved situation to talalgia
(4) interpretation of result:
Can find out that removing callus emulsion and blank emulsion all have improvement result in various degree to the callus of trier and talalgia symptom from table 5 and 6, wherein removing callus emulsion D2-5 effect is all better than blank, points out plant extract provided by the present invention to improve significantly effect to callus and talalgia; Wherein the result of use of removing callus emulsion D1 does not have obvious difference compared with blank, describes Chinese medicine composition contained in removing callus emulsion D1 and does not also reach valid density; Removing callus emulsion D2-5 compares and learns, its removing callus and talalgia effect raise along with effective ingredient concentration and improve, but its trend improving effect slowly reduces, and the removing callus effect of effective ingredient 60% is not significantly improved compared with 50%; Consider from result of use and economic aspect, it is comparatively rational that Chinese medicine composition accounts for formulation weight percent 10-50%.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (6)
1. a Chinese medicine composition, is characterized in that, described Chinese medicine composition is made up of the raw material of following weight parts:
Rhizoma Chuanxiong 30-45 part, Caulis Sargentodoxae 30-45 part, Radix Sophorae Flavescentis 30-45 part, Spina Gleditsiae 20-35 part, Fructus Kochiae 10-25 part, Herba Menthae 10-25 part.
2. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the raw material of following weight parts:
Rhizoma Chuanxiong 35-40 part, Caulis Sargentodoxae 35-40 part, Radix Sophorae Flavescentis 35-40 part, Spina Gleditsiae 25-30 part, Fructus Kochiae 15-20 part, Herba Menthae 15-20 part.
3. Chinese medicine composition according to claim 1 and 2, is characterized in that, described Chinese medicine composition is the extract of 50-70% ethanol water.
4. the application of the Chinese medicine composition according to any one of claim 1-3 in cosmetics.
5. application according to claim 4, is characterized in that, described Chinese medicine composition as prevention, improve or eliminate the effective ingredient of callus and add in cosmetics.
6. removing callus cosmetics, is characterized in that, described toiletry bag is containing the Chinese medicine composition described in any one of percetage by weight 10-50% claim 1-3, and surplus is the carrier and combination thereof that allow in cosmetics.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039093A (en) * | 2016-08-04 | 2016-10-26 | 张培江 | Composition for softening foot and hand calluses and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142953A (en) * | 2013-03-11 | 2013-06-12 | 郑汉 | Foot-bath health-protective Chinese medicament powder |
| CN104524476A (en) * | 2015-01-17 | 2015-04-22 | 马建国 | Tincture for treating callus and preparation method thereof |
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- 2015-11-10 CN CN201510759930.XA patent/CN105343166A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142953A (en) * | 2013-03-11 | 2013-06-12 | 郑汉 | Foot-bath health-protective Chinese medicament powder |
| CN104524476A (en) * | 2015-01-17 | 2015-04-22 | 马建国 | Tincture for treating callus and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039093A (en) * | 2016-08-04 | 2016-10-26 | 张培江 | Composition for softening foot and hand calluses and preparation method thereof |
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