CN105327190A - Traditional Chinese medicine for treating bone malposition and tendon injury type lumbar disc herniation and preparing method thereof - Google Patents
Traditional Chinese medicine for treating bone malposition and tendon injury type lumbar disc herniation and preparing method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating bone malposition and tendon injury type lumbar disc herniation and a preparing method thereof. The traditional Chinese medicine is prepared from radix ceratostigmae, clerodendron cyrtophyllum, dragon tree, bitter bamboo shavings, rhizoma tupistrae chinensis, hairy clovershrub roots, common edelweiss herb, polygonum coriaceum, ophiorrhiza succirubra, russula rubra, hylocereus undatus, calogyne pilosa, heliotropium arborescens and eragrostis ferruginea. The traditional Chinese medicine has the advantages of being capable of becoming effective quickly, definite in curative effect, high in safety, free of side effect and capable of avoiding relapse when used for treating bone malposition and tendon injury type lumbar disc herniation by means of traditional Chinese medicine theories.
Description
Technical field
The present invention relates to pharmaceutical technology, particularly relate to and a kind ofly treat Chinese medicine and the preparation method that type prolapse of lumbar intervertebral disc is hindered in bone sprain.
Background technology
Prolapse of lumbar intervertebral disc is one of comparatively common illness, mainly because lumbar intervertebral disc each several part (vertebral pulp, fibrous ring and cartilaginous lamina), especially vertebral pulp, after having degenerative change in various degree, under the effect of external force factor, the Anular disruption of intervertebral disc, nucleus pulposus is from part outstanding (or deviating from) of breaking in rear or intraspinal tube, adjacent ridge nerve root is caused to be stimulated or oppress, thus generation flank pain, a series of clinical symptoms such as side lower limb or two numbness of lower limbs, pain.Prolapse of lumbar intervertebral disc is the highest with waist 4-5, waist 5-sacrum 1 sickness rate, accounts for 95%.
Basic disease cause mainly contains the following aspects: 1. the degenerative change of lumbar intervertebral disc is Fundamentals; The regression main manifestations of vertebral pulp is the reduction of water content, and vertebra can be caused to save unstability because of dehydration, the pathological change among a small circle such as to loosen; The regression main manifestations of fibrous ring is the reduction of tough and tensile degree.2. damage; Prolonged and repeated external force causes slight damage, has increased the weight of the degree of regression.3. the weakness of intervertebral disc self anatomical factors; Intervertebral disc lacks blood circulation gradually after growing up, and repair ability is poor.On the basis of above-mentioned factor effect, certain can cause intervertebral disc bear the risk factor that pressure raises suddenly, the poor vertebral pulp of elasticity namely may being made through becoming not too tough and tensile fibrous ring, causing Nucleus pulposus.4. inherited genetic factors; The report that prolapse of lumbar intervertebral disc has familial to fall ill, coloured race's this disease sickness rate is low.5. waist sacrum congenital anomaly; Comprise lumbar sacralization, lumbarization, hemivertebra, Minor articulus deformity and articular process asymmetric etc.The stress that above-mentioned factor can make lower lumbar spine bear changes, thus forms intradiscal pressure rising and easily regression and damage occur.
Clinical symptoms mainly contains the following aspects: 1. lumbago: be the symptom that Most patients occurs at first, incidence rate about 91%.Because fibrous ring is outer and posterior longitudinal ligament is subject to vertebral pulp stimulation, produce lower waist induction pain through hole nervi vertebralis, sometimes can with pain of buttock.2. lower limb radiating pain: although high-order prolapse of lumbar intervertebral disc (waist 2 ~ 3, waist 3 ~ 4) can cause femoral neuralgia, rare clinical, less than 5%.Most patient is waist 4 ~ 5, waist 5 ~ sacrum 1 gap is given prominence to, and shows as sciatica.Typical case sciatica be from lower waist to buttocks, thigh rear, little leg outer side until the radiating pain of foot, when the abdominal pressure such as sneeze and cough increases, pain can be aggravated.The limbs of radiating pain mostly are side, and only only a few central type or central authorities other type Nucleus pulposus person shows as two symptoms of lower extremity.The reason of sciatica has three: stimulation and the autoimmune response of the intervertebral disc generation chemical substance of 1. breaking make nerve root generation chemical inflammatory; 2. outstanding vertebral pulp compressing or stretching have the nerve root of inflammation, its venous return is obstructed, increases the weight of edema further, make to increase the sensitivity of pain; 3. the nerve root ischemia of pressurized.Above-mentioned three kinds of factors interrelate, Acute aggravated factors each other.3. cauda equina nerve symptom: cauda equina nerve is oppressed in the vertebral pulp outstanding to dead astern or prolapsus, the disc tissue that dissociates, and its main manifestations is stool, urine obstacle, perineum and crissum paraesthesia.Can be there is the symptoms such as the out of control and two lower limb paresiss of defecation in severe patient, rare clinically.
The method of current treatment prolapse of lumbar intervertebral disc mainly contains non-operative treatment treatment and operative treatment, non-operative treatment also claims expectant treatment, conventional method has: various Chinese patent medicine, Western medicine Drug therapy, traction therapeutic, manipulation, naturopathy, acupuncture and moxibustion therapy, fascia therapy, closed treating, vertebral pulp dissolution treatment etc., although can be good at relief of symptoms or pain, but therapeutic effect is still undesirable, there is treatment time long, weak curative effect, somewhat expensive and have the defects such as side effect.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of and treats Chinese medicine and the preparation method that type prolapse of lumbar intervertebral disc is hindered in bone sprain, and this Chinese medicine hinders to treatment bone sprain that type prolapse of lumbar intervertebral disc has determined curative effect, toxic and side effects is little.
In order to solve the problems of the technologies described above, the invention provides and a kind ofly treat the Chinese medicine that type prolapse of lumbar intervertebral disc is hindered in bone sprain, wherein, comprise following raw medicinal material: Herba Salviae Cavaleriei, Folium Isatidis wood, Folium Dracaenae cambodianae, Caulis pleioblasti in Taeniam, Rhizoma Tupistrae Chinensis, Radix Campylotropis hirtellae, Herba Leontopodii Leontopodioidis, Rhizoma Polygoni coriacei, the expensive grass in ground, DAHONGGU, Hylocereus undatus, fragrant from root, Cortex Rosae Normalis Radicis and Herba Eragrostidis ferrugineae.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Salviae Cavaleriei 10 ~ 20 parts, 20 ~ 30 parts, Folium Isatidis wood, Folium Dracaenae cambodianae 10 ~ 20 parts, Caulis pleioblasti in Taeniam 15 ~ 25 parts, Rhizoma Tupistrae Chinensis 5 ~ 15 parts, Radix Campylotropis hirtellae 20 ~ 30 parts, Herba Leontopodii Leontopodioidis 10 ~ 20 parts, Rhizoma Polygoni coriacei 8 ~ 18 parts, expensive careless 10 ~ 20 parts of ground, DAHONGGU 8 ~ 18 parts, Hylocereus undatus 10 ~ 20 parts, from root perfume (or spice) 20 ~ 30 parts, Cortex Rosae Normalis Radicis 10 ~ 20 parts and Herba Eragrostidis ferrugineae 20 ~ 30 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Salviae Cavaleriei 10 ~ 15 parts, 20 ~ 25 parts, Folium Isatidis wood, Folium Dracaenae cambodianae 13 ~ 18 parts, Caulis pleioblasti in Taeniam 17 ~ 22 parts, Rhizoma Tupistrae Chinensis 8 ~ 13 parts, Radix Campylotropis hirtellae 22 ~ 27 parts, Herba Leontopodii Leontopodioidis 12 ~ 17 parts, Rhizoma Polygoni coriacei 10 ~ 15 parts, expensive careless 10 ~ 15 parts of ground, DAHONGGU 13 ~ 18 parts, Hylocereus undatus 15 ~ 20 parts, from root perfume (or spice) 23 ~ 28 parts, Cortex Rosae Normalis Radicis 15 ~ 20 parts and Herba Eragrostidis ferrugineae 25 ~ 30 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Salviae Cavaleriei 14 parts, 22 parts, Folium Isatidis wood, Folium Dracaenae cambodianae 18 parts, Caulis pleioblasti in Taeniam 20 parts, Rhizoma Tupistrae Chinensis 12 parts, Radix Campylotropis hirtellae 24 parts, Herba Leontopodii Leontopodioidis 16 parts, Rhizoma Polygoni coriacei 10 parts, expensive careless 15 parts of ground, DAHONGGU 14 parts, Hylocereus undatus 20 parts, from fragrant 24 parts of root, Cortex Rosae Normalis Radicis 18 parts and Herba Eragrostidis ferrugineae 26 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Salviae Cavaleriei 10 parts, 25 parts, Folium Isatidis wood, Folium Dracaenae cambodianae 15 parts, Caulis pleioblasti in Taeniam 22 parts, Rhizoma Tupistrae Chinensis 10 parts, Radix Campylotropis hirtellae 26 parts, Herba Leontopodii Leontopodioidis 12 parts, Rhizoma Polygoni coriacei 14 parts, expensive careless 12 parts of ground, DAHONGGU 16 parts, Hylocereus undatus 16 parts, from fragrant 26 parts of root, Cortex Rosae Normalis Radicis 15 parts and Herba Eragrostidis ferrugineae 30 parts.
Wherein, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Wherein, when the dosage form of described Chinese medicine is membranous patch, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;
Second step, powder 6.5 ~ 7.5 weight portion prepared by the first step, polyvinyl alcohol 2 ~ 3 weight portion, the abundant mix and blend of glycerol 0.5 ~ 1 weight portion, produces to without minute bubbles, leaves standstill 20 ~ 30 minutes, obtained mixing paste;
3rd step, the mixing paste film-making machine even spread masking prepared by second step, under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the mode that both sides are fixing, containing powder sticking glass paper, obtains membranous patch.
Beneficial effect of the present invention: Chinese medicine of the present invention, utilizes the theory of Chinese medical science that China is traditional, to the advantage that treatment bone sprain is hindered type prolapse of lumbar intervertebral disc pointed strong, rapid-action, determined curative effect, safe without toxic side effect and not easily recurred.
Detailed description of the invention
The invention provides and a kind ofly treat the Chinese medicine that type prolapse of lumbar intervertebral disc is hindered in bone sprain, wherein, comprise following raw medicinal material: Herba Salviae Cavaleriei, Folium Isatidis wood, Folium Dracaenae cambodianae, Caulis pleioblasti in Taeniam, Rhizoma Tupistrae Chinensis, Radix Campylotropis hirtellae, Herba Leontopodii Leontopodioidis, Rhizoma Polygoni coriacei, the expensive grass in ground, DAHONGGU, Hylocereus undatus, fragrant from root, Cortex Rosae Normalis Radicis and Herba Eragrostidis ferrugineae, Semen-pilus Strophanthi divaricati, Agapetes neriifolia (King et Prain) Airv-Shaw and purple fiber crops.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Herba Salviae Cavaleriei: [another name] Radix ceratostigmatis willemottiani.[source] medical material Ji Yuan: be the rhizome of Maguireothamnus speciosus Ophirrhiza cantoniensis.[nature and flavor] are bitter; Cold.[function cures mainly] clearing and antitussive; Tranquillizing and allaying excitement; Reducing swelling and alleviating pain.Main epersalgia cough; Cholera is vomited and diarrhoea; Neurasthenia; Menoxenia; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Folium Isatidis wood: [another name] Herba Diclipterae Chinensis, smelly Ye Shu, sheep miaow green grass or young crops, blue or green heart grass, smelly Folium Isatidis, the public green grass or young crops of duck, light grandmother, Prunus mume Da Ye Qing, woody Folium Isatidis.[source] is Verbena officinalis Ke Cheng paulownia platymiscium Folium Isatidis wood, is used as medicine with root, leaf.The whole year can adopt.Root section is dried; Leaf is cleaned and is dried in the shade or using fresh herb.[nature and flavor] are bitter, cold.[function cures mainly] clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For preventing and treating epidemic cerebrospinal meningitis, epidemic encephalitis type B, cure cold headache, measles complicated pneumonia, mumps, tonsillitis, infectious hepatitis, dysentery, urinary tract infection.[extracts] " national Chinese herbal medicine compilation "
Folium Dracaenae cambodianae: [another name] bamboo wood ginseng, Garcinia mangostana sugarcane.[source] Agavaceae Folium Dracaenae cambodianae, is used as medicine with tuber.[nature and flavor] are sweet, cool.The cough-relieving of [function cures mainly] profit liver, clearing away heat and cooling blood.Cure mainly chronic hepatitis, pertussis, bronchitis, pulmonary tuberculosis, spitting of blood, spit blood, chronic tonsillitis, pharyngolaryngitis, after calentura, waste heat is unclear.[extracts] " national Chinese herbal medicine compilation "
Caulis pleioblasti in Taeniam: [source] medical material Ji Yuan: be the intermediate layer scraped after the stem stalk removing crust of grass bitter bamboo.[nature and flavor] are bitter; Cool.[function cures mainly] heat clearing away; Reduce phlegm; Removing heat from blood.Main dysphoria with smothery sensation vomiting; Expectorant heat syndrome cough is breathed heavily; Difficulty and pain in micturition; Hematuria.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Tupistrae Chinensis: [another name] Rhizoma Polygonati Odorati, A Qingguo.[source] medical material Ji Yuan: be the rhizome of liliaceous plant Rhizoma Tupistrae Chinensis.[nature and flavor] sweet in the mouth; Micro-pungent; Property is put down.[function cures mainly] nourishing YIN and clearing away lung-heat; Blood circulation promoting and blood stasis dispelling.The main empty dryness of the lung; Cough dry pharynx; Puerperal asthenia; Women does consumptive disease; Traumatic injury; Fracture.[extracts] " China's book on Chinese herbal medicine "
Radix Campylotropis hirtellae: [another name] Radix Campylotropis Hirtella (Herba Myrsines Africanae), large and red, Radix Indigoferae Szechuenensis, oily root, rust root, cattle spit blood, native Radix Sophorae Tonkinensis.For the root of the leguminous plant Mao Hangzi tip.[nature and flavor] are puckery; Micro-hardship; Tepor.[function cures mainly] promoting blood flow to regulate menstruation; Regulating QI to relieve pain; Clearing away heat-damp and promoting diuresis.Main menoxenia; Amenorrhea; Dysmenorrhea; Leucorrhea; Dysentery; Gastric abscess; Traumatic hemorrhage; Impetigo; Burn due to hot liquid or fire.[extracts] " China's book on Chinese herbal medicine "
Herba Leontopodii Leontopodioidis: [another name] Leontopodium leontopodioides (Willd.) Beauv..[source] medical material Ji Yuan: be the herb of feverfew HUANGBAI(sic) Leontopodium leontopodioides (Willd.) Beauv..[nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] clearing away heat and cooling blood.Main cold, fever; Pharyngolaryngitis; Nephritis.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Polygoni coriacei: [another name] chicken feet king, Rhizoma Bistortae, hornet seven, Rhizoma Polygoni Paleachi.[source] medical material Ji Yuan: be the rhizome of polygonaceae plant leather leaf knotweed.[nature and flavor] are bitter; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing.Main hygropyretic dysentery; Diarrhoea; Carbuncle; Hemorrhoid; Gingival swelling and pain; Erosion of the oral mucosa; Burn; Venom.[extracts] " China's book on Chinese herbal medicine "
Ground your grass: [source] medical material Ji Yuan: be the root of osmanthus, Maguireothamnus speciosus Yunnan Herba ophiorrhizae japonicae.[nature and flavor] are pungent; Temperature.[function cures mainly] relaxing muscles and tendons and activating QI and blood in the collateral; Expelling wind and removing dampness.Main bones and muscles pain due to rheumatism; Impairment caused by overstrain pain.[extracts] " China's book on Chinese herbal medicine "
DAHONGGU: [another name] Russula, Zhu mushroom.[source] medical material Ji Yuan: be the sporophore of Russulaceae fungus DAHONGGU.[nature and flavor] are sweet; Slightly warm in nature.[function cures mainly] nourishes blood; Removing blood stasis; Dispel the wind.Main blood deficiency and yellow complexion; Prolonged lochia; Joint aches.[extracts] " China's book on Chinese herbal medicine "
Hylocereus undatus: [source] medical material Ji Yuan: be the stem of Cactaeous plants Hylocereus undatus.[nature and flavor] are sweet; Light; Cool in nature.[function cures mainly] relaxing muscles and tendons and activating QI and blood in the collateral; Removing toxic substances and promoting subsidence of swelling.Main injury and bone fracture; Mumps; Skin ulcer swells; Burn and scald.[extracts] " China's book on Chinese herbal medicine "
Fragrant from root: [another name] Cortex Cinnamomi grass, U.S. post grass, U.S. flowers and plants, sharp root perfume, mountain garland chrysanthemum, root Radix seu Caulis fici Martinii.[source] medical material Ji Yuan: for Goodeniaceae plant is from the herb of root.[nature and flavor] acrid in the mouth; Warm in nature.[function cures mainly] expelling wind and cold; Promoting flow of QI and blood; Antidote against snake bite.Main air arthralgia due to cold pain; Stomachache; Stomachache; Traumatic injury; Venom.[extracts] " China's book on Chinese herbal medicine "
Cortex Rosae Normalis Radicis: [another name] perfume flower, Rosa Banksiae Ait, Folium Styracis Suberifoliae, Radix Buddlejae Butterflybush, Arisaema balansae Engl., HONGCI skin.[source] medical material Ji Yuan: be the root bark of rosaceous plant single-lobe Lignum Aquilariae Resinatum.[nature and flavor] are puckery; Temperature.[return through] Liver Channel.[function cures mainly] promoting blood flow to regulate menstruation; Detumescence dissipating blood stasis.Main menoxenia; Wound is red and swollen.[extracts] " China's book on Chinese herbal medicine "
Herba Eragrostidis ferrugineae: [another name] journey stings gold.[source] medical material Ji Yuan: be the root of grass Herba Eragrostidis ferrugineae.[nature and flavor] are bitter; Cool.[function cures mainly] promoting blood circulation to remove blood stasis.Main internal traumatic injury; Bones and muscles pain.[extracts] " China's book on Chinese herbal medicine "
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Salviae Cavaleriei 10 ~ 20 parts, 20 ~ 30 parts, Folium Isatidis wood, Folium Dracaenae cambodianae 10 ~ 20 parts, Caulis pleioblasti in Taeniam 15 ~ 25 parts, Rhizoma Tupistrae Chinensis 5 ~ 15 parts, Radix Campylotropis hirtellae 20 ~ 30 parts, Herba Leontopodii Leontopodioidis 10 ~ 20 parts, Rhizoma Polygoni coriacei 8 ~ 18 parts, expensive careless 10 ~ 20 parts of ground, DAHONGGU 8 ~ 18 parts, Hylocereus undatus 10 ~ 20 parts, from root perfume (or spice) 20 ~ 30 parts, Cortex Rosae Normalis Radicis 10 ~ 20 parts and Herba Eragrostidis ferrugineae 20 ~ 30 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Salviae Cavaleriei 10 ~ 15 parts, 20 ~ 25 parts, Folium Isatidis wood, Folium Dracaenae cambodianae 13 ~ 18 parts, Caulis pleioblasti in Taeniam 17 ~ 22 parts, Rhizoma Tupistrae Chinensis 8 ~ 13 parts, Radix Campylotropis hirtellae 22 ~ 27 parts, Herba Leontopodii Leontopodioidis 12 ~ 17 parts, Rhizoma Polygoni coriacei 10 ~ 15 parts, expensive careless 10 ~ 15 parts of ground, DAHONGGU 13 ~ 18 parts, Hylocereus undatus 15 ~ 20 parts, from root perfume (or spice) 23 ~ 28 parts, Cortex Rosae Normalis Radicis 15 ~ 20 parts and Herba Eragrostidis ferrugineae 25 ~ 30 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Salviae Cavaleriei 14 parts, 22 parts, Folium Isatidis wood, Folium Dracaenae cambodianae 18 parts, Caulis pleioblasti in Taeniam 20 parts, Rhizoma Tupistrae Chinensis 12 parts, Radix Campylotropis hirtellae 24 parts, Herba Leontopodii Leontopodioidis 16 parts, Rhizoma Polygoni coriacei 10 parts, expensive careless 15 parts of ground, DAHONGGU 14 parts, Hylocereus undatus 20 parts, from fragrant 24 parts of root, Cortex Rosae Normalis Radicis 18 parts and Herba Eragrostidis ferrugineae 26 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Salviae Cavaleriei 10 parts, 25 parts, Folium Isatidis wood, Folium Dracaenae cambodianae 15 parts, Caulis pleioblasti in Taeniam 22 parts, Rhizoma Tupistrae Chinensis 10 parts, Radix Campylotropis hirtellae 26 parts, Herba Leontopodii Leontopodioidis 12 parts, Rhizoma Polygoni coriacei 14 parts, expensive careless 12 parts of ground, DAHONGGU 16 parts, Hylocereus undatus 16 parts, from fragrant 26 parts of root, Cortex Rosae Normalis Radicis 15 parts and Herba Eragrostidis ferrugineae 30 parts.
Wherein, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Wherein, when the dosage form of described Chinese medicine is membranous patch, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;
Second step, powder 6.5 ~ 7.5 weight portion prepared by the first step, polyvinyl alcohol 2 ~ 3 weight portion, the abundant mix and blend of glycerol 0.5 ~ 1 weight portion, produces to without minute bubbles, leaves standstill 20 ~ 30 minutes, obtained mixing paste;
3rd step, the mixing paste film-making machine even spread masking prepared by second step, under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the mode that both sides are fixing, containing powder sticking glass paper, obtains membranous patch.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1: capsule
Get Herba Salviae Cavaleriei 100g, Folium Isatidis wood 250g, Folium Dracaenae cambodianae 150g, Caulis pleioblasti in Taeniam 220g, Rhizoma Tupistrae Chinensis 100g, Radix Campylotropis hirtellae 260g, Herba Leontopodii Leontopodioidis 120g, Rhizoma Polygoni coriacei 140g, ground expensive careless 120g, DAHONGGU 160g, Hylocereus undatus 160g, from root fragrant 260g, Cortex Rosae Normalis Radicis 150g and Herba Eragrostidis ferrugineae 300g;
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 hour, pulverize, sieve, obtain 300 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15:0.2, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Embodiment 2: membranous patch
Get Herba Salviae Cavaleriei 140g, Folium Isatidis wood 220g, Folium Dracaenae cambodianae 180g, Caulis pleioblasti in Taeniam 200g, Rhizoma Tupistrae Chinensis 120g, Radix Campylotropis hirtellae 240g, Herba Leontopodii Leontopodioidis 160g, Rhizoma Polygoni coriacei 100g, ground expensive careless 150g, DAHONGGU 140g, Hylocereus undatus 200g, from root fragrant 240g, Cortex Rosae Normalis Radicis 180g and Herba Eragrostidis ferrugineae 260g;
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 50 object powder, and adding relative to the determining alcohol of mixture quality 2 times is the ethanol of 85%, reflux 1.5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 200 object powder;
Second step, powder 7 weight portion prepared by the first step, polyvinyl alcohol 2 weight portion, the abundant mix and blend of glycerol 0.5 weight portion, produces to without minute bubbles, leaves standstill 25 minutes, obtained mixing paste;
3rd step, the mixing paste film-making machine even spread masking prepared by second step, under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the mode that both sides are fixing, containing powder sticking glass paper, obtains membranous patch.
Toxicity test:
Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 20 ~ 34g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Capsule prepared by embodiments of the invention 1 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 27g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore Chinese drug anesthesia medicine acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: by the capsule of the embodiment of the present invention 1 to three groups of mices (often organize 15) by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: fetch the 80 routine bone sprains coming from the court's orthopaedics patient and hinder type prolapse of lumbar intervertebral disc patient, male 44 people, female 36 people; 30 ~ 65 years old age, medical history 6 months ~ 8 years; Lumbar intervertebral disc central authorities protruding type 42 example, outstanding 38 examples in position, side; Sick in L3-4 intervertebral 21 example, L4-5 intervertebral 22 is routine, L5-S1 intervertebral 37 example.All cases is all made a definite diagnosis through CT.80 routine patients are divided into treatment by Chinese herbs group and Chinese patent medicine matched group at random, treatment group 40 people, male 21 people, female 19 people; 30 ~ 62 years old age, medical history 6 months ~ 7 years; Lumbar intervertebral disc central authorities protruding type 22 example, outstanding 18 examples in position, side; Sick in L3-4 intervertebral 10 example, L4-5 intervertebral 12 is routine, L5-S1 intervertebral 18 example.Matched group 40 people, male 23 people, female 17 people; 32 ~ 65 years old age, medical history 9 months ~ 8 years; Lumbar intervertebral disc central authorities protruding type 20 example, outstanding 20 examples in position, side; Sick in L3-4 intervertebral 11 example, L4-5 intervertebral 10 is routine, L5-S1 intervertebral 19 example.
Diagnostic criteria: with reference to the diagnostic criteria in " the Chinese medical disease Standardization of diagnosis and curative effect " of State Administration of Traditional Chinese Medicine.1, there are waist wound, chronic strain or are subject to cold-damp history.Major part patient has chronic back pain history at premorbid.2, often person between twenty and fifty are betided.3, lumbago is to buttocks and lower limb radiation, and when abdominal pressure increases (as cough, sneeze), pain increases the weight of.4, scoliosis, waist physiology radians disappears, and diseased region vertebra is other tenderness, and to lower limb radiation, waist limitation of activity.5, the lower limb innervation district that gets involved feels irritated or blunt, and course of disease elder can occur amyotrophy.Leg raising straight or the reinforcement test positive, knee joint, Achilles tendon reflex weaken or disappear, and big toe dorsiflexion power weakens.6, x-ray takes the photograph sheet inspection: scoliosis, and waist physiology lordosis disappears, and pathological interspinal dish may narrow, and neighboring edge has osteophytosis.CT examination can show position and the degree of intervertebral disk hernia.
Syndrome Differentiation of Traditional Chinese Medicine standard: type is hindered in bone sprain: how because of caused by lumbar sprain and QI divergeny, injury from falling down or hyperflexion; Hinder back lumbar part hurt like hell, walk to alter and do swollen, can not bend and stretch pitching, difficulty of changing one's position, cough, have violent referred pain when deeply breathing, pain can to buttocks, thigh radiation, and body of the tongue is purple, stringy and hesitant pulse.
Therapeutic Method:
Treatment group: take capsule prepared by the embodiment of the present invention 1, every day 3 times, each 31 month is 1 course for the treatment of.Treat 3 courses for the treatment of.
Matched group: oral " Yaobitong Capsule", every day 3 times, each 31 month is 1 course for the treatment of.Treat 3 courses for the treatment of.
The standard of curative effect evaluation: cure: symptom disappears completely or close to disappearing, straight-leg raising test can reach more than 80 °, can recover original work.Effective: symptom partial disappearance, straight-leg raising test 60 °-80 °, can recover original work.Take a turn for the better: symptom partial disappearance, lumbago and skelalgia alleviates, and straight-leg raising test significantly improves before comparatively treating, and can serve as comparatively light work.Invalid: symptom, without obviously alleviating, can not be worked.
Therapeutic outcome: see table 1 and table 2.
Table 1 liang group treats Clinical efficacy comparison (example) after 3 courses for the treatment of respectively
| Group | n | Cure | Effective | Take a turn for the better | Invalid | Total effective rate |
| Treatment group | 40 | 17 | 11 | 10 | 2 | 38(95％) |
| Matched group | 40 | 8 | 15 | 9 | 8 | 32(80％) |
As can be seen from Table 1, adopt treatment by Chinese herbs bone of the present invention sprain to hinder type prolapse of lumbar intervertebral disc, relative to matched group, on therapeutic effect, there is significant improvement.
Cure number after a table 2 liang group treats 3 courses for the treatment of respectively and cure ratio comparatively (example/%)
| Group | n | 1 course for the treatment of | 2 courses for the treatment of | 3 courses for the treatment of |
| Treatment group | 17 | 5(12.5％) | 13(32.5％) | 17(42.5％) |
| Matched group | 8 | 0(0％) | 4(10％) | 8(20％) |
As can be seen from Table 2, adopt treatment by Chinese herbs bone of the present invention sprain to hinder type prolapse of lumbar intervertebral disc, relative to matched group, not only better efficacy, takes effect also faster, significantly can shorten and treat the course for the treatment of.
According to the clinical statistics in above table and toxicity test, Chinese medicine provided by the invention have rapid-action, effective percentage is high, the advantage of safe without toxic side effect; The 8 routine follow-up of patients 1 year that 17 examples of simultaneously curing treatment group and matched group are cured, result is added up, treatment group 17 example, and without recurrence, relapse rate is 0% (1/17); The routine patient of matched group 8, in 8 routine patients of healing, recurs 1 people, relapse rate 12.5% (1/8).
Model case: Huang, male, 55 years old, suffers from prolapse of lumbar intervertebral disc and has a surplus, then according to classical symptom for 6 years: caused by injury from falling down; Hinder back lumbar part hurt like hell, walk to alter and do swollen, can not bend and stretch pitching, difficulty of changing one's position, cough, have violent referred pain when deeply breathing, pain can to buttocks, thigh radiation, and body of the tongue is purple, and stringy and hesitant pulse, typing is that type prolapse of lumbar intervertebral disc is hindered in bone sprain.Take the capsule of Chinese medicine preparation embodiment 1 of the present invention, every day 3 times, each 3, treat healing in 3 months, follow up a case by regular visits to and do not recur for 1 year.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. treat the Chinese medicine that type prolapse of lumbar intervertebral disc is hindered in bone sprain, it is characterized in that, comprise following raw medicinal material: Herba Salviae Cavaleriei, Folium Isatidis wood, Folium Dracaenae cambodianae, Caulis pleioblasti in Taeniam, Rhizoma Tupistrae Chinensis, Radix Campylotropis hirtellae, Herba Leontopodii Leontopodioidis, Rhizoma Polygoni coriacei, ground is your grass, DAHONGGU, Hylocereus undatus, fragrant from root, Cortex Rosae Normalis Radicis and Herba Eragrostidis ferrugineae.
2. Chinese medicine as claimed in claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Salviae Cavaleriei 10 ~ 20 parts, 20 ~ 30 parts, Folium Isatidis wood, Folium Dracaenae cambodianae 10 ~ 20 parts, Caulis pleioblasti in Taeniam 15 ~ 25 parts, Rhizoma Tupistrae Chinensis 5 ~ 15 parts, Radix Campylotropis hirtellae 20 ~ 30 parts, Herba Leontopodii Leontopodioidis 10 ~ 20 parts, Rhizoma Polygoni coriacei 8 ~ 18 parts, expensive careless 10 ~ 20 parts of ground, DAHONGGU 8 ~ 18 parts, Hylocereus undatus 10 ~ 20 parts, from root perfume (or spice) 20 ~ 30 parts, Cortex Rosae Normalis Radicis 10 ~ 20 parts and Herba Eragrostidis ferrugineae 20 ~ 30 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Salviae Cavaleriei 10 ~ 15 parts, 20 ~ 25 parts, Folium Isatidis wood, Folium Dracaenae cambodianae 13 ~ 18 parts, Caulis pleioblasti in Taeniam 17 ~ 22 parts, Rhizoma Tupistrae Chinensis 8 ~ 13 parts, Radix Campylotropis hirtellae 22 ~ 27 parts, Herba Leontopodii Leontopodioidis 12 ~ 17 parts, Rhizoma Polygoni coriacei 10 ~ 15 parts, expensive careless 10 ~ 15 parts of ground, DAHONGGU 13 ~ 18 parts, Hylocereus undatus 15 ~ 20 parts, from root perfume (or spice) 23 ~ 28 parts, Cortex Rosae Normalis Radicis 15 ~ 20 parts and Herba Eragrostidis ferrugineae 25 ~ 30 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Salviae Cavaleriei 14 parts, 22 parts, Folium Isatidis wood, Folium Dracaenae cambodianae 18 parts, Caulis pleioblasti in Taeniam 20 parts, Rhizoma Tupistrae Chinensis 12 parts, Radix Campylotropis hirtellae 24 parts, Herba Leontopodii Leontopodioidis 16 parts, Rhizoma Polygoni coriacei 10 parts, expensive careless 15 parts of ground, DAHONGGU 14 parts, Hylocereus undatus 20 parts, from fragrant 24 parts of root, Cortex Rosae Normalis Radicis 18 parts and Herba Eragrostidis ferrugineae 26 parts.
5. the Chinese medicine as described in claims 1 to 3, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Salviae Cavaleriei 10 parts, 25 parts, Folium Isatidis wood, Folium Dracaenae cambodianae 15 parts, Caulis pleioblasti in Taeniam 22 parts, Rhizoma Tupistrae Chinensis 10 parts, Radix Campylotropis hirtellae 26 parts, Herba Leontopodii Leontopodioidis 12 parts, Rhizoma Polygoni coriacei 14 parts, expensive careless 12 parts of ground, DAHONGGU 16 parts, Hylocereus undatus 16 parts, from fragrant 26 parts of root, Cortex Rosae Normalis Radicis 15 parts and Herba Eragrostidis ferrugineae 30 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is membranous patch, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;
Second step, powder 6.5 ~ 7.5 weight portion prepared by the first step, polyvinyl alcohol 2 ~ 3 weight portion, the abundant mix and blend of glycerol 0.5 ~ 1 weight portion, produces to without minute bubbles, leaves standstill 20 ~ 30 minutes, obtained mixing paste;
3rd step, the mixing paste film-making machine even spread masking prepared by second step, under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the mode that both sides are fixing, containing powder sticking glass paper, obtains membranous patch.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is membranous patch, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;
Second step, powder 6.5 ~ 7.5 weight portion prepared by the first step, polyvinyl alcohol 2 ~ 3 weight portion, the abundant mix and blend of glycerol 0.5 ~ 1 weight portion, produces to without minute bubbles, leaves standstill 20 ~ 30 minutes, obtained mixing paste;
3rd step, the mixing paste film-making machine even spread masking prepared by second step, under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the mode that both sides are fixing, containing powder sticking glass paper, obtains membranous patch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510902752.1A CN105327190A (en) | 2015-12-08 | 2015-12-08 | Traditional Chinese medicine for treating bone malposition and tendon injury type lumbar disc herniation and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510902752.1A CN105327190A (en) | 2015-12-08 | 2015-12-08 | Traditional Chinese medicine for treating bone malposition and tendon injury type lumbar disc herniation and preparing method thereof |
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| Publication Number | Publication Date |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101444611A (en) * | 2007-11-26 | 2009-06-03 | 佛山德众药业有限公司 | Traditional Chinese medicine composition for treating lumbocrural pain and lumbar intervertebral disc protrusion and preparation method thereof |
| CN104173689A (en) * | 2014-08-29 | 2014-12-03 | 朱芳继 | Medicine for treating traumatic injury, lumbar disc herniation and scapulohumeral periarthritis and preparation method of medicine |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101444611A (en) * | 2007-11-26 | 2009-06-03 | 佛山德众药业有限公司 | Traditional Chinese medicine composition for treating lumbocrural pain and lumbar intervertebral disc protrusion and preparation method thereof |
| CN104173689A (en) * | 2014-08-29 | 2014-12-03 | 朱芳继 | Medicine for treating traumatic injury, lumbar disc herniation and scapulohumeral periarthritis and preparation method of medicine |
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Application publication date: 20160217 |