CN1053115C - Medicine for acute diarrhea of baby and preparation thereof - Google Patents
Medicine for acute diarrhea of baby and preparation thereof Download PDFInfo
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- CN1053115C CN1053115C CN97109040A CN97109040A CN1053115C CN 1053115 C CN1053115 C CN 1053115C CN 97109040 A CN97109040 A CN 97109040A CN 97109040 A CN97109040 A CN 97109040A CN 1053115 C CN1053115 C CN 1053115C
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Abstract
The present invention discloses a new medicament for treating infantile acute diarrhea, and a preparation method thereof. The medicine uses evodia rutaecarpa, clove, dried ginger, lexon, white atractylodes rhizome, betel nut, coptis and semen plantaginis as raw materials. According to different situations of all the traditional Chinese medicines, the raw materials are respectively and proportionally prepared after the steps of air drying, pulverization, solvent extraction, etc. Then, the raw materials are concentrated, skin penetrable liquid is added, and the mixtures are prepared into paste attached to a rubber cloth similar to a woundplast and applied to acupuncture points. The present invention reduces the pain for taking medicines and having injections for infants, and is easily accepted by children. The present invention adopts the unique recipe and the preparation method, and the medicament has the advantages of easy and convenient use and obvious treating effect.
Description
The present invention relates to a kind of medicine for the treatment of the infant acute diarrhea, is the Chinese patent medicine medicine for external use of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Infantile diarrhea is one of modern department of pediatrics four main point diseases of China, also is one of world child frequently-occurring disease.It is tender and lovely that children's has internal organs, the physiological characteristics that shape gas does not fill, no matter weakness of spleen and stomach is being invaded by exogenous pathogen or internal damage caused by infantile dyspepsia, all can cause transformation and transportation of the spleen and stomach imbalance and times of defecation takes place increases, excrement matter rare or shape such as water sample, in case ill, control wrong treatment as mistake, then pathological changes is rapid, easy impairment of YIN impairment of YANG, the danger disease that very then causes negative and positive all to be taken off.
The primary disease Drug therapy is run into the problem of following existence at present both at home and abroad:
1, form of Chinese drug is traditional decoction, powder, needs the oral then difficulty of infant;
2, western medicine does not especially have special good method to viral enteritis, and the treatment course of disease is longer;
Though 3 also have a kind of unguentum or external agent of treatment infantile diarrhea, effect is not fairly obvious, and there is stimulation the part of using, and the patient still has to rely on some Western medicine and Chinese patent medicine.
The objective of the invention is according to theory of Chinese medical science, rational prescription, the extraction active ingredient of science, pure Chinese medicinal preparation utilizes interior disease external therapy, and point application changes route of administration, and a kind of medicine that reaches quick, simple and direct treatment infant acute diarrhea is provided.
Another object of the present invention provides the preparation method of this infant acute diarrhea therapeutic agent.
Solution of the present invention is based on motherland's medical science to infantile diarrhea and pathogenetic understanding of complication and Therapeutic Principle, research achievement with reference to modern pharmacology, from motherland's medical treasure-house, spleen invigorating, the warming middle-JIAO of screening, regulate the flow of vital energy, removing dampness, pure and impure plant amedica of letting out, by theory of Chinese medical science ancestral side, skim the cream off milk, make it all to have function of spleen and stomach regulating, cold and heat treating both the principal and the secondary aspects of a disease at the same time, the merit of the stomach function regulating that helps digestion, reach Yin-yang ascending-descending, pure and impure purpose of taking their own roads, by interior disease external therapy, the point application medication, thereby in short-term, effectively treat the disease of infant acute diarrhea.
Medicine of the present invention is made (consumption is a weight portion) by following component:
5～15 parts of 10～20 parts of Fructus Chebulaes of 5～10 portions of Rhizoma Zingiberiss of 10～20 portions of Flos Caryophyllis of Fructus Evodiae
10～20 parts of 10～25 portions of Semen Plantaginiss of 10～20 portions of Rhizoma Coptidis of 10～20 portions of Semen Arecaes of the Rhizoma Atractylodis Macrocephalae
The formula optimization weight proportion scope of preparation medicine of the present invention is:
5～10 parts of 10～15 parts of Fructus Chebulaes of 5～8 portions of Rhizoma Zingiberiss of 10～15 portions of Flos Caryophyllis of Fructus Evodiae
10～15 parts of 10～20 portions of Semen Plantaginiss of 10～15 portions of Rhizoma Coptidis of 10～15 portions of Semen Arecaes of the Rhizoma Atractylodis Macrocephalae
The optimum weight proportioning of medicine of the present invention is:
10 parts of 7 parts of Rhizoma Atractylodis Macrocephalaes of 10 parts of Fructus Chebulaes of 6.5 portions of Rhizoma Zingiberiss of 12 portions of Flos Caryophyllis of Fructus Evodiae
10 parts of 15 portions of Semen Plantaginiss of 10 portions of Rhizoma Coptidis of Semen Arecae
Above-mentioned each component is made medicine production method of the present invention is:
1, gets Fructus Evodiae, Flos Caryophylli, Rhizoma Coptidis, drying and crushing to 120 order fine powder earlier;
2, get dried ginger slice, Fructus Chebulae, Rhizoma Atractylodis Macrocephalae sheet, Semen Plantaginis with the extraction of Diluted Alcohol solution soaking, pour out residue, extracting solution concentrates;
3, the Rhizoma Zingiberis that will extract, the Rhizoma Atractylodis Macrocephalae are soaked and were boiled, take out decoction liquor in 1～2 hour;
4, ethanol extract, decoction liquor and Fructus Evodiae, Flos Caryophylli, Rhizoma Coptidis powder, mixing fully are mixed into ointment, add skin liquid, make the formula of the applying ointment or plaster medicine for external use of similar adhesive bandage formula, sealing.
Said skin liquid can be for Oleum menthae or/and vegetable oil.
The clinical use result of medicine of the present invention shows that following advantage is arranged:
1, to select pure vegetable Chinese herbal medicine for use be raw material in the present invention, and each component meets the pharmaceutical control and administration regulation, utilizes the comprehensive function treatment infant acute diarrhea of the Chinese medicine of respectively distinguishing the flavor of, and do not have chemical external agent, nontoxic to human body.
2, Transdermal absorption of the present invention is good, and to complete, damaged skin has no stimulation, no skin allergy.
3, anxious poison test shows that this medicine has no side effect to body to skin in external of the present invention.
4, the present invention has the intestinal of slowing down ahead running through experimental study, and stronger analgesic activity is arranged.
5, the present invention marks the inhibitory action that has in various degree to the examination bacterium.
6, has certain C PE inhibitory action.
7, result of the test shows the child antidiarrhea patch to mice nonspecific immunity function, and body fluid and cellular immune function all have certain potentiation.
8, the present invention only needs to apply ointment or plaster on the umbilicus of infant and gets final product, and the minimizing children's takes medicine the hardship of having an injection, and is very easily accepted by the child, and is easy to use, good effect, short treating period.
For showing the therapeutic effect of medicine of the present invention to the infant acute diarrhea, the present invention is divided into " child antidiarrhea patch " (the clinical title of the present invention) (1212 examples at random through the infant of 372 routine systems clinical observations (0～3 years old), the present invention) Western medicine group (110 examples, matched group), the Radix Puerariae Siberian cocklebur connects intestinal, huoxiang zhengqi powder group (50 examples, be the Chinese medicine matched group), diagnosis of treatment infantile diarrhea and treatment standard according to the promulgation of Chinese medicine management board, carry out clinical observation research, the result shows: effective percentage of the present invention is 92.45%, than western medicine group (69.09%) and Chinese medicine matched group (76%) significant difference (P＜0.05) is arranged.On treatment time, the present invention has utmost point marked difference (P＜0.01) than Chinese medicine and western medicine matched group.
External method: 0.5g/ pastes 1g/ and pastes
The umbilicus 1g/ that applies ointment or plaster pastes the antidiarrheal cave, changes dressings 1 time in the every cave of two tsu san lis 0.5g/ time in 24 hours.
8, clinical observation: (see Table one, table two) is attached
Table one 1, curative effect compare:
| Cure (%) | Effectively (%) | Invalid (%) | Add up to | ||
| I | The present invention | 85(9043) | 5(5.32) | 4(4.25) | 94 |
| Western medicine group | 12(25.53) | 15(31.91) | 20(42.56) | 47 | |
| The Chinese medicine matched group | 13(65.00) | 4(20.00) | 3(15.00) | 20 | |
| II | The present invention | 60(78.95) | 9(11.84) | 7(9.21) | 76 |
| Western medicine group | 32(80.00) | 6(15.00) | 2(5.00) | 40 | |
| The Chinese medicine matched group | 10(55.56) | 3(16.67) | 5(27.77) | 18 | |
| III | The present invention | 17(40.48) | 20(47.62) | 5(11.90) | 42 |
| Western medicine group | 5(21.74) | 6(26.09) | 12(52.17) | 23 | |
| The Chinese medicine matched group | 3(25.00) | 5(41.67) | 4(33.33) | 12 | |
| P＞0.05 | P＜0.05 | P＜0.01 | |||
Time ratio in table two treatment (complete)
Embodiment 1: take by weighing raw material by following prescription: 18 parts of embodiment 2 of 18 portions of plantain seeds of 18 portions of coptiss of 18 portions of betel nuts of 13 parts of bighead atractylodes rhizomes of 18 parts of myrobalans of 8 portions of rhizoma zingiberis of 18 portions of cloves of evodia rutaecarpa: take by weighing raw material by following prescription: 15 parts of embodiment 3 of 15 portions of plantain seeds of 13 portions of coptiss of 13 portions of betel nuts of 8 parts of bighead atractylodes rhizomes of 13 parts of myrobalans of 7 portions of rhizoma zingiberis of 14 portions of cloves of evodia rutaecarpa: take by weighing raw material by following prescription: 12 parts of 10 portions of plantain seeds of 12 portions of coptiss of 12 portions of betel nuts of 6 parts of bighead atractylodes rhizomes of 11 parts of myrobalans of 6 portions of rhizoma zingiberis of 10 portions of cloves of evodia rutaecarpa are made preparation method of the present invention by above-mentioned prescription and are:
| 1～3 day (%) | 4～5 days (%) | More than 5 days (%) | Add up to | ||
| I | The present invention | 82(96.47) | 3(3.53) | 0(0) | 85 |
| Western medicine group | 4(33.33) | 5(41.67) | 3(25.00) | 12 | |
| The Chinese medicine matched group | 8(61.54) | 4(30.77) | 1(7.69) | 13 | |
| II | The present invention | 48(80.00) | 8(13.34) | 4(6.66) | 60 |
| Western medicine group | 22(68.75) | 8(25.00) | 2(6.25) | 32 | |
| The Chinese medicine matched group | 4(40.00) | 5(50.00) | 1(10.00) | 10 | |
| III | The present invention | 11(64.71) | 2(11.76) | 4(23.53) | 17 |
| Western medicine group | 0(0.00) | 2(40.00) | 3(60.00) | 5 | |
| The Chinese medicine matched group | 2(66.67) | 1(33.33) | 0(0.00) | 3 | |
1, gets Fructus Evodiae, Flos Caryophylli, Rhizoma Coptidis drying and crushing to 120 order fine powder earlier;
2, get dried ginger slice, Fructus Chebulae's fruit, Rhizoma Atractylodis Macrocephalae sheet, Semen Plantaginis, the extraction of Diluted Alcohol solution soaking, pour out residue, extracting solution concentrates;
3, the Rhizoma Zingiberis that will extract, the Rhizoma Atractylodis Macrocephalae are soaked and were boiled, take out decoction liquor in 1～2 hour;
4, ethanol extract, decoction liquor and Fructus Evodiae, Flos Caryophylli, Rhizoma Coptidis powder mixing fully are mixed into ointment, add Oleum menthae or/and vegetable oil, make the formula of the applying ointment or plaster medicine for external use of similar adhesive bandage formula, sealing.
Claims (5)
1, a kind of medicine for the treatment of the infant acute diarrhea is characterized in that: it is the medicament of being made by the following weight proportion raw material:
5～15 parts of 10～20 parts of Fructus Chebulaes of 5～10 portions of Rhizoma Zingiberiss of 10～20 portions of Flos Caryophyllis of Fructus Evodiae
10～20 parts of 10～25 portions of Semen Plantaginiss of 10～20 portions of Rhizoma Coptidis of 10～20 portions of Semen Arecaes of the Rhizoma Atractylodis Macrocephalae
2, the medicine of treatment infant acute diarrhea according to claim 1, wherein the weight proportion of each raw material is:
5～10 parts of 10～15 parts of Fructus Chebulaes of 5～8 portions of Rhizoma Zingiberiss of 10～15 portions of Flos Caryophyllis of Fructus Evodiae
10～15 parts of 10～20 portions of Semen Plantaginiss of 10～15 portions of Rhizoma Coptidis of 10～15 portions of Semen Arecaes of the Rhizoma Atractylodis Macrocephalae
3, the medicine of treatment infant acute diarrhea according to claim 1, wherein the weight proportion of each raw material is:
10 parts of 7 parts of Rhizoma Atractylodis Macrocephalaes of 10 parts of Fructus Chebulaes of 6.5 portions of Rhizoma Zingiberiss of 12 portions of Flos Caryophyllis of Fructus Evodiae
10 parts of 15 portions of Semen Plantaginiss of 10 portions of Rhizoma Coptidis of Semen Arecae
4, the preparation method of the medicine of the described treatment infant of claim 1 acute diarrhea is characterized in that: get Fructus Evodiae, Flos Caryophylli, Rhizoma Coptidis drying and crushing to 120 order fine powder earlier; Get dried ginger slice, Fructus Chebulae's fruit, Rhizoma Atractylodis Macrocephalae sheet, Semen Plantaginis, the extraction of Diluted Alcohol solution soaking, pour out residue, extracting solution concentrates; The Rhizoma Zingiberis, the Rhizoma Atractylodis Macrocephalae that extracted soaked boil, take out decoction liquor; At last ethanol extract, decoction liquor and Fructus Evodiae, Flos Caryophylli, Rhizoma Coptidis powder mixing fully are mixed into ointment, add skin liquid, make the formula of the applying ointment or plaster medicine for external use of similar adhesive bandage formula, sealing.
5, preparation method according to claim 4 is characterized in that said skin liquid can be for Oleum menthae or/and vegetable oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97109040A CN1053115C (en) | 1997-03-15 | 1997-03-15 | Medicine for acute diarrhea of baby and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97109040A CN1053115C (en) | 1997-03-15 | 1997-03-15 | Medicine for acute diarrhea of baby and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1193527A CN1193527A (en) | 1998-09-23 |
| CN1053115C true CN1053115C (en) | 2000-06-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97109040A Expired - Fee Related CN1053115C (en) | 1997-03-15 | 1997-03-15 | Medicine for acute diarrhea of baby and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1053115C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840764A (en) * | 2015-06-12 | 2015-08-19 | 赵景岩 | Traditional Chinese medicine preparation for treating improper-eating acute infantile diarrhea and preparation method thereof |
| CN105125790A (en) * | 2015-08-21 | 2015-12-09 | 霍传生 | Qi regulating and stomach strengthening preparation for treating gasteremphraxis and preparation method of preparation |
| CN105055806A (en) * | 2015-09-14 | 2015-11-18 | 南京正亮医药科技有限公司 | Medicinal preparation for treating diarrhea |
-
1997
- 1997-03-15 CN CN97109040A patent/CN1053115C/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 《河南中医药学刊》10(4) 1995.1.1 彭勃，吕宏生，吕承全教授治疗慢性结肠炎经验 * |
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| Publication number | Publication date |
|---|---|
| CN1193527A (en) | 1998-09-23 |
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