CN105310971A - Acne removing skin care product - Google Patents
Acne removing skin care product Download PDFInfo
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- CN105310971A CN105310971A CN201510724881.6A CN201510724881A CN105310971A CN 105310971 A CN105310971 A CN 105310971A CN 201510724881 A CN201510724881 A CN 201510724881A CN 105310971 A CN105310971 A CN 105310971A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention provides an acne removing skin care product, which consists of rhEGF, a cortex phellodendri extract, an artemia extract and a herba violae extract. The skin care product, in terms of total weight, consists of the following components in percentage by weight: 0.0001-0.001% of the rhEGF, 0.2-0.8% of the cortex phellodendri extract, 0.35-1% of the artemia extract and 0.20-0.6% of the herba violae extract. In the acne removing skin care product disclosed by the invention, the weight content of the rhEGF is just 1-10ug/ml, which is greatly lower than a conventional adding amount; and on the basis of a synergistic effect generated from the rhEGF which is combined with the cortex phellodendri extract, the artemia extract and the herba violae extract, the skin care product can achieve functions of dredging pores, balancing grease secretion, comprehensively repairing and enhancing the barrier function of skin, shortening a wound healing time and relieving the formation of scars, so as to thoroughly eliminate acnes without scars.
Description
Technical field
The invention belongs to cosmetic technical field, be specifically related to a kind of anti-acne skin care item.
Background technology
Epidermal growth factor (EGF) is a kind of multi-functional Growth of Cells promotive factor, there is Promote cell's growth widely active, accelerate human skin cell's speed of growth, promoting the new Growth of Cells breeding of skin, is the deciding factor affecting skin health.But with advancing age and the deterioration of environment, in human body, the content of EGF reduces gradually, causes skin health impaired.Natural EGF is extensively present in mammalian body, and its content is low, and extract difficulty large, cost is high, and people adopt rhEGF to substitute natural EGF usually.RhEGF can stimulate the various cells of outer embryo rhEGF layer and endodermal origin as cornea, epithelium etc., makes it breed.Its biological effect comprises: 1) promote that low molecular weight compound is initiatively transported in cell from extracellular, increase the nutrient substance of cell; 2) glycolysis is activated to increase respiratory metabolism, energy activating phosphatase fructokinase; 3) the outer macromolecular synthesis of irritation cell, as hyaluronic acid and glycoprotein.4) synthesis of RNA and protein is activated; 5) synthesis of DNA is promoted; 6) some materials of body are as the synthesis of fruit acid, prostaglandin to promote cell proliferation to promote.These biological effects show, rhEGF, by conducted signal, causes a series of Biochemical changes in cell, starts the gene relevant with cell division, makes akinete enter cell division phase, thus make cell proliferation.RhEGF can stimulate the formation of granulation tissue and promote the epithelization of granulation tissue, also scalable collagen degradation and renewal, collagen fiber are arranged in a linear fashion, prevent connective tissue paraplasm, so there is the effect shortened the wound healing time and reduce cicatrization, there is good effect to preventing and nursing acne.There are the skin care item containing rhEGF in prior art, to aspects such as anti-acnes, there is certain positive effect.Because external source rhEGF occurs Physical Loss or Damage and inactivation in the processes such as skin permeation, make the content of rhEGF in skin care item will far beyond EGF concentration several times in human body even hundreds of times just can produce a desired effect, through skin verification experimental verification, the effect that can control symptom clinically just can be reached when the concentration of rhEGF is 100 μ g/ml in skin care item, when the concentration of rhEGF is 300 more than μ g/ml, clinical symptoms just starts to take a turn for the better.In skin care item, the addition of rhEGF is too high, but inefficiency, considerably increase production cost.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of anti-acne skin care item, these skin care item comprise rhEGF and Cortex Phellodendri extract, artemia extract and Herba Violae extract, four kinds of compositions are composite has significant cooperative effect for this, energy dredging pore, Bergamot Mint Extract, comprehensive reparation also improves the barrier function of skin, shortens the wound healing time and reduces the effect of cicatrization, thorough removing acne.
Technical scheme provided by the invention is anti-acne skin care item, and it is made up of rhEGF, Cortex Phellodendri extract, artemia extract and Herba Violae extract.
Artemia (ARTEMIA) extract is a kind of halomereid extract; containing rich in protein and polypeptide; in addition also containing GP4G; after entering human body; ATP can be changed into rapidly; makeup energy instantaneously; wake up because of old and feeble or the affected by environment and cell of dormancy; activate various physiological activity and the metabolism of Skin Cell; improve the protein synthesis played a crucial role in epidermis; the function also having DNA protection and repair, plays an important role to numerous cell metabolism procedure.The parameters of artemia extract is: transparency liquid, ph (20 DEG C) 5.0 ~ 6.0; Density (20 DEG C) 1.00 ~ 1.02g/cm
3; Refractive index (20 DEG C) 1.33 ~ 1.34; Solid content: 12.0 ~ 18g/kg; GP4G content 145 ~ 195ppm.
Herba Violae extract is pulverized by Herba Violae dry product, the ethanol of 50 ~ 80v% is added in the ratio of 1g:10 ~ 20ml, reflux, extract, 3 times at 70 ~ 90 DEG C, each 1 ~ 2h, merge extractive liquid, concentration and recovery ethanol, adjust PH to 2 ~ 8, add adsorbent and be separated chlorophyll, cross 0.45 μm of membrane filtration removing adsorbent afterwards, obtain Herba Violae extracting solution, the content of its effective ingredient total flavones is 15 ~ 30mg/g.
Cortex Phellodendri extract is pulverized by Cortex Phellodendri, the ratio being 1g:8 ~ 12ml in solid-liquid ratio decocts with water 3 times, each decoction 1 ~ 3h, merge extractive liquid, filters, filtrate is concentrated into 1/3 ~ 1/2 of original volume, add the dehydrated alcohol precipitation of concentrated solution volume 1/3 ~ 1/2, centrifugal filtration, get supernatant concentration and reclaim ethanol, obtain cortex phellodendri extract, containing Cortex Phellodendri powder 0.09 ~ 0.11g in every g Cortex Phellodendri extract liquid.
With the total restatement of these skin care item, the weight content of said components is respectively: rhEGF0.0001 ~ 0.001%, Cortex Phellodendri extract 0.2 ~ 0.8%, artemia extract 0.35 ~ 1%, Herba Violae extract 0.20 ~ 0.6%.
Described skin care item are acne eliminating cream or anti-acne emulsion.The conventional formulation of anti-acne cream/emulsion:
rhEGF0.0001～0.001％；
Cortex Phellodendri extract 0.2 ~ 0.8%;
Artemia extract 0.35 ~ 1%;
Herba Violae extract 0.20 ~ 0.6%;
Emulsifying agent: 0.5 ~ 10%;
Emollient: 5 ~ 40%;
Excipient thickening agent: 0.1 ~ 10%;
Wetting agent: 5 ~ 30%;
Antiseptic: convention amount;
Antioxidant: convention amount;
Deionized water: surplus.
The preparation method of described skin care item is: first undertaken primary emulsifying by oil phase in skin care item and aqueous phase, adjust the temperature of this emulsification system 35 ~ 40 DEG C time, add rhEGF, Cortex Phellodendri extract, artemia extract and Herba Violae extract, system is through stirring, and further cooling is up to the standards discharging.
Compared with prior art, the present invention has following beneficial effect:
1) artemia extract is similar to rhEGF with the peptide bond structure of Herba Violae extract; very easily intersect between peptide bond, coil, the reaction of the space displacement such as compositions; rhEGF is surrounded by the peptide molecule key ring-type of artemia extract and Herba Violae extract; protect rhEGF space structure; avoid rhEGF inactivation, greatly raise the efficiency.
2) Cortex Phellodendri extract, artemia extract and Herba Violae extract energy Bergamot Mint Extract, dissolution angular embolization, anti-bacteria propagation, reparation cicatrix, promote that anti-acne composition absorbs through skin, promote pox wound healing, makes skin recover normal exquisiteness soft and smooth.
3) Cortex Phellodendri extract, artemia extract and Herba Violae extract and skin have the good compatibility, can be absorbed by the skin rapidly, rhEGF is combined with Cortex Phellodendri extract, artemia extract and Herba Violae extract and is very easily absorbed by the skin, and reduces the rhEGF loss in process of osmosis.
4) in skin care item of the present invention, the weight content of rhEGF is only 1 ~ 10 μ g/ml, well below conventional addition, synergism is produced with Cortex Phellodendri extract, artemia extract and Herba Violae extract, energy dredging pore, Bergamot Mint Extract, comprehensive reparation also improves the barrier function of skin, shortens the wound healing time and reduces the effect of cicatrization, thorough removing acne and non-trace.
Detailed description of the invention
The present invention is further elaborated for following specific embodiment, but not as a limitation of the invention.
Embodiment 1
The formula following (w%) of anti-acne cream:
rhEGF0.0001％；
Cortex Phellodendri extract 0.2%;
Artemia extract 0.35%;
Herba Violae extract 0.20%;
Glyceryl stearate: 3%;
Cetearyl alcohol: 5%;
Glycerol: 10%;
Propylene glycol: 10%;
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%;
Ceteth-20:1%;
Cocoanut oil alcohol sodium sulfovinate: 0.5%;
Hydroxyethyl-cellulose: 0.7%;
Antiseptic: appropriate;
Essence: appropriate;
Deionized water: surplus.
The preparation of Herba Violae extract: Herba Violae dry product is pulverized, the ethanol of 50v% is added in the ratio of 1g:10ml, reflux, extract, 3 times at 70 DEG C, each 1h, merge extractive liquid, concentration and recovery ethanol, adjust PH to 2, add adsorbent and be separated chlorophyll, cross 0.45 μm of membrane filtration removing adsorbent afterwards, obtain Herba Violae extracting solution, the content of its effective ingredient total flavones is 15mg/g.
The preparation of Cortex Phellodendri extract: Cortex Phellodendri is pulverized, the ratio being 1g:8ml in solid-liquid ratio decocts with water 3 times, each decoction 1h, merge extractive liquid, filters, filtrate is concentrated into 1/3 of original volume, add the dehydrated alcohol precipitation of concentrated solution volume 1/3, centrifugal filtration, get supernatant concentration and reclaim ethanol, obtain cortex phellodendri extract, containing Cortex Phellodendri powder 0.09g in every g Cortex Phellodendri extract liquid.
Preparation method:
1) in oil phase process tank, oil phase material (propylene glycol, cetearyl alcohol, glyceryl stearate, hydrogenation gather certain herbaceous plants with big flowers alkene) is dropped in still, starts agitator simultaneously, be heated to 92 ~ 98 DEG C, start agitator simultaneously, material is melted completely;
2) in aqueous phase pretreatment tank, glycerol is all dropped in still, start stirring, and hydroxyethyl-cellulose is slowly dropped in still in powder form, it is made fully to disperse, then other aqueous phases (water, ceteth-20, cocoanut oil alcohol sodium sulfovinate) are dropped in still, be heated to 92 ~ 98 DEG C, be stirred to evenly;
3) filtered oil phase suck into preheating emulsion tank in, rear suction aqueous phase, and start scraper plate stirring, rapid stirring, homogenizer (start emulsifying kettle rapid stirring and homogenizer about 10 ~ 12 minutes) with this, now emulsifying temperature in the kettle should not lower than 85 DEG C.After carrying out vacuum emulsification, insulated and stirred after 10 ~ 15 minutes, then starts chiller cooling.
4) when temperature drops to 55 ~ 60 DEG C, add essence, temperature drops to 35 ~ 40 DEG C, adds rhEGF, Cortex Phellodendri extract, artemia extract and Herba Violae extract, antiseptic, continues to stir, when temperature continues to be down to 30 DEG C, and discharging after the assay was approved.
Embodiment 2
The formula following (w%) of anti-acne cream:
rhEGF0.001％
Cortex Phellodendri extract 0.8%
Artemia extract 1%
Herba Violae extract 0.6%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
The preparation of Herba Violae extract: Herba Violae dry product is pulverized, the ethanol of 80v% is added in the ratio of 1g:20ml, reflux, extract, 3 times at 90 DEG C, each 2h, merge extractive liquid, concentration and recovery ethanol, adjust PH to 8, add adsorbent and be separated chlorophyll, cross 0.45 μm of membrane filtration removing adsorbent afterwards, obtain Herba Violae extracting solution, the content of its effective ingredient total flavones is 30mg/g.
The preparation of Cortex Phellodendri extract: Cortex Phellodendri is pulverized, the ratio being 1g:12ml in solid-liquid ratio decocts with water 3 times, each decoction 3h, merge extractive liquid, filters, filtrate is concentrated into 1/2 of original volume, add the dehydrated alcohol precipitation of concentrated solution volume 1/2, centrifugal filtration, get supernatant concentration and reclaim ethanol, obtain cortex phellodendri extract, containing Cortex Phellodendri powder 0.11g in every g Cortex Phellodendri extract liquid.
The preparation method of the anti-acne cream of the present embodiment is consistent with the preparation method of embodiment 1.
Embodiment 3
The formula following (w%) of anti-acne cream:
rhEGF0.005％
Cortex Phellodendri extract 0.4%
Artemia extract 0.6%
Herba Violae extract 0.4%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
The preparation of Herba Violae extract: Herba Violae dry product is pulverized, the ethanol of 75v% is added in the ratio of 1g:15ml, reflux, extract, 3 times at 80 DEG C, each 1.5h, merge extractive liquid, concentration and recovery ethanol, adjust PH to 6, add adsorbent and be separated chlorophyll, cross 0.45 μm of membrane filtration removing adsorbent afterwards, obtain Herba Violae extracting solution, the content of its effective ingredient total flavones is 20mg/g.
The preparation of Cortex Phellodendri extract: Cortex Phellodendri is pulverized, the ratio being 1g:10ml in solid-liquid ratio decocts with water 3 times, each decoction 2h, merge extractive liquid, filters, filtrate is concentrated into 1/3 of original volume, add the dehydrated alcohol precipitation of concentrated solution volume 1/2, centrifugal filtration, get supernatant concentration and reclaim ethanol, obtain cortex phellodendri extract, containing Cortex Phellodendri powder 0.10g in every g Cortex Phellodendri extract liquid.
The preparation method of the anti-acne cream of the present embodiment is consistent with the preparation method of embodiment 1.
Reference examples 1
The formula following (w%) of anti-acne cream:
RhEGF lyophilized powder: 0.01%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
Its preparation method is identical with embodiment 1.
Reference examples 2
The formula following (w%) of anti-acne cream:
RhEGF lyophilized powder: 0.01%
Cortex Phellodendri extract: 0.3%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
Its preparation method is identical with embodiment 1.
Reference examples 3
The formula following (w%) of anti-acne cream:
RhEGF lyophilized powder: 0.01%
Cortex Phellodendri extract: 0.3%
Artemia extract: 0.5%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
Its preparation method is identical with embodiment 1.
Reference examples 4
The formula following (w%) of anti-acne cream:
RhEGF lyophilized powder: 0.01%
Cortex Phellodendri extract: 0.3%
Herba Violae extract: 0.3%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
The preparation of Herba Violae extract is identical with embodiment 1, and the preparation method of this cream is identical with embodiment 1.
For verifying the anti-acne effect of anti-acne skin care item of the present invention, now carry out following experiment.
Choose light, the facial ordinary comedo of moderate (with reference to PillSburv and international improvement acne powder method diagnosis mild or moderate acne person) volunteer totally 70, wherein man 38, female 32 people; Age between 17 ~ 35 years old, 28.3 years old mean age; The course of disease 4 weeks ~ 7 years, average 3.5 years, before smearing these skin care item 2 weeks, does not use glucocorticosteroid hormone, tretinoin and antibiotics, without hyperlipidemia and hepatic and renal function abnormal, excessive drinking of compacting, avoids sunburst or ultraviolet excessive radiation.
Above-mentioned 70 volunteers are divided into 7 groups at random, often organize 10 people, be respectively experimental group 1 ~ 3 and matched group 1 ~ 4.Experimental group 1 ~ 3 uses the anti-acne of the embodiment of the present invention 1 ~ 3 respectively, and matched group 1 ~ 4 uses the acne eliminating cream of reference examples 1 ~ 4 respectively.Experimenter cleans after pars affecta skin disease wipes and open with warm water, and every day sooner or later smears counter sample 1 time, stop using between the operating period other drug or skin care item, 4 weeks by a definite date.Before the treatment and treatment after, respectively to experimenter's face inflammatory damage sum (inflamed papules and pustule summation), non-inflammatory lesions summation (summation of Whiteheads and blackhead) counting, the untoward reaction after itemized record use simultaneously.
Evaluation criterion:
Base is healed: therapeutic index >=90%;
Effective: 60%≤therapeutic index < 90%;
Progressive: 20%≤therapeutic index < 60%;
Invalid: therapeutic index < 20%.
Total skin lesion number × 100% before therapeutic index=(before treatment the rear total skin lesion number of total skin lesion number-treatment)/treatment;
Effective percentage=(base heal number+effective number)/total number of persons × 100%.
| Group | Base more | Effective | Progressive | Invalid | Effective percentage (%) |
| Matched group 1 | 0 | 3 | 3 | 4 | 30 |
| Matched group 2 | 0 | 4 | 4 | 2 | 40 |
| Matched group 3 | 1 | 3 | 3 | 3 | 40 |
| Matched group 4 | 3 | 2 | 2 | 3 | 50 |
| Experimental group 1 | 5 | 4 | 1 | 0 | 90 |
| Experimental group 2 | 6 | 3 | 1 | 0 | 90 |
| Experimental group 3 | 5 | 4 | 0 | 1 | 90 |
Claims (5)
1. anti-acne skin care item, is characterized in that: it comprises rhEGF, Cortex Phellodendri extract, artemia extract and Herba Violae extract.
2. anti-acne skin care item according to claim 1, it is characterized in that: with the total restatement of these skin care item, the weight content of said components is respectively: rhEGF0.0001 ~ 0.001%, Cortex Phellodendri extract 0.2 ~ 0.8%, artemia extract 0.35 ~ 1%, Herba Violae extract 0.20 ~ 0.6%.
3. anti-acne skin care item according to claim 1, it is characterized in that: the preparation method of described Herba Violae extract is as follows: Herba Violae dry product is pulverized, the ethanol of 50 ~ 80v% is added in the ratio of 1g:10 ~ 20ml, reflux, extract, 3 times at 70 ~ 90 DEG C, each 1 ~ 2h, merge extractive liquid, concentration and recovery ethanol, adjust PH to 2 ~ 8, add adsorbent and be separated chlorophyll, cross 0.45 μm of membrane filtration removing adsorbent afterwards, obtain Herba Violae extracting solution, the content of its effective ingredient total flavones is 15 ~ 30mg/g.
4. anti-acne skin care item according to claim 1, it is characterized in that: the preparation method of described Cortex Phellodendri extract is as follows: Cortex Phellodendri is pulverized, the ratio being 1g:8 ~ 12ml in solid-liquid ratio decocts with water 3 times, each decoction 1 ~ 3h, merge extractive liquid, filter, filtrate is concentrated into 1/3 ~ 1/2 of original volume, add the dehydrated alcohol precipitation of concentrated solution volume 1/3 ~ 1/2, centrifugal filtration, get supernatant concentration and reclaim ethanol, obtain cortex phellodendri extract, containing Cortex Phellodendri powder 0.09 ~ 0.11g in every g Cortex Phellodendri extract liquid.
5. the anti-acne skin care item according to any one of Claims 1 to 4, is characterized in that: it is anti-acne cream or anti-acne emulsion.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108652989A (en) * | 2018-06-27 | 2018-10-16 | 广州科缇生物科技有限公司 | A kind of gel and preparation method thereof with acne-removing |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108652989A (en) * | 2018-06-27 | 2018-10-16 | 广州科缇生物科技有限公司 | A kind of gel and preparation method thereof with acne-removing |
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