CN114569515A - Hydrogel for repairing damaged skin barrier after medical and art and preparation method thereof - Google Patents
Hydrogel for repairing damaged skin barrier after medical and art and preparation method thereof Download PDFInfo
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- CN114569515A CN114569515A CN202210309848.7A CN202210309848A CN114569515A CN 114569515 A CN114569515 A CN 114569515A CN 202210309848 A CN202210309848 A CN 202210309848A CN 114569515 A CN114569515 A CN 114569515A
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- 238000002360 preparation method Methods 0.000 title abstract description 19
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 27
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Classifications
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
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Abstract
The invention provides hydrogel for repairing damaged skin barrier after medical and art and a preparation method thereof, wherein the hydrogel comprises the following raw materials in parts by weight: 15-20 parts of hyaluronic acid, 10-15 parts of sodium alginate, 5-10 parts of glycerol, 8-12 parts of trehalose, 3-5 parts of epsilon-polylysine, 4-6 parts of citronella essential oil, 5-8 parts of valerian essential oil, 9-13 parts of citrus aurantium extract, 10-13 parts of green tangerine extract and 12-15 parts of mussel-like mucin. The hydrogel prepared by the invention has good anti-inflammatory effect, good moisturizing effect, growth promotion and healing promotion, high repair efficiency and lasting effect on the skin barrier damaged after medical arts, has good effect on the skin barrier repair after medical arts, can obviously improve the skin damage improvement rate, reduce the positive rate of lactic acid stabbing pain experiments, and simultaneously improve the water content of the horny layer.
Description
Technical Field
The invention relates to the field of hydrogel, in particular to hydrogel for repairing damaged skin barrier after medical and art and a preparation method thereof.
Background
In the medical cosmetology field, the laser cosmetology technology is widely applied, such as laser spot removal, laser acne removal and the like. The laser beauty technology has the advantages of high safety, good beauty effect and the like, is favored by people who love beauty, but the photothermal effect of the laser also easily causes damage to the skin barrier, so the laser beauty technology is necessary and very critical for repairing the damaged skin barrier after medical and artistic work. The existing repair product has the problems of poor repair effect, slow repair efficiency, high adverse reaction rate and the like.
Disclosure of Invention
In view of the above, the invention provides hydrogel for repairing damaged skin barrier after medical and artistic works and a preparation method thereof, and the prepared hydrogel has a good effect on repairing skin barrier after medical and artistic works, and has the advantages of good repairing effect, high repairing efficiency and no adverse reaction.
The technical scheme of the invention is realized as follows: the hydrogel for repairing damaged skin barrier after medical and art comprises the following raw materials in parts by weight: 15-20 parts of hyaluronic acid, 10-15 parts of sodium alginate, 5-10 parts of glycerol, 8-12 parts of trehalose, 3-5 parts of epsilon-polylysine, 4-6 parts of citronella essential oil, 5-8 parts of valerian essential oil, 9-13 parts of citrus aurantium extract, 10-13 parts of green tangerine extract and 12-15 parts of mussel-like mucin.
Further, the feed comprises the following raw materials in parts by weight: 18 parts of hyaluronic acid, 12 parts of sodium alginate, 8 parts of glycerol, 10 parts of trehalose, 4 parts of epsilon-polylysine, 5 parts of citronella essential oil, 7 parts of valerian essential oil, 11 parts of citrus aurantium extract, 12 parts of green tangerine extract and 13 parts of mussel-like mucin.
Further, the preparation method of the citronella essential oil comprises the following steps: taking lemongrass powder, and adopting supercritical CO2Extracting with an extractor under 19MPa and 60 deg.C,extracting for 30min to obtain citronella essential oil.
Further, the preparation method of the valerian essential oil comprises the following steps: taking rhizoma et radix Valerianae powder, and extracting with supercritical CO2Extracting with an extractor under 23MPa at 45 deg.C for 60min to obtain rhizoma et radix Valerianae essential oil.
Further, the preparation method of the bitter orange extract comprises the following steps: taking bitter orange powder, wherein the ratio of the raw materials to the liquid is 1 kg: adding distilled water 5L, performing microwave treatment for 30min under the condition of power of 28kW, performing steam distillation extraction, collecting distillate, extracting with diethyl ether, collecting extract, filtering, performing rotary evaporation on the filtrate, and performing vacuum drying at 45 ℃ for 30min to obtain the bitter orange extract.
Further, the preparation method of the kumquat extract comprises the following steps: taking green tangerine peel powder, and mixing the raw materials according to a feed-liquid ratio of 1 kg: adding 70 wt% ethanol solution into 8L, shaking at 300rpm and 55 deg.C for 1.5h, centrifuging, collecting supernatant, filtering, concentrating, and drying to obtain pericarpium Citri Tangerinae extract.
Further, the preparation method of the hydrogel comprises the following steps: according to the feed liquid mass ratio of 1:1 preparing distilled water, adding bitter orange flower extract and kumquat extract into one third of the distilled water, and stirring and mixing to obtain a mixed solution; adding citronella essential oil and valerian essential oil into the mixed solution under stirring, and then adding mussel-like mucin; and finally, adding the balance of distilled water, hyaluronic acid, sodium alginate, glycerol, trehalose and epsilon-polylysine, stirring for 22-28h at the temperature of 45-55 ℃, freeze-drying, and sterilizing by adopting electron beam irradiation, wherein the irradiation dose is 20kGy, so as to prepare the target hydrogel.
Compared with the prior art, the invention has the beneficial effects that:
(1) according to the invention, mussel-like mucin is combined with the tangerine extract, the citronella essential oil and the valerian essential oil, and epsilon-polylysine, sodium alginate, trehalose and the like are added, so that the prepared hydrogel has a good effect on repairing skin barriers after medical and artistic activities, the skin damage improvement rate is remarkably improved, the lactic acid sting experiment positive rate is reduced, and the water content of the horny layer is improved.
(2) The hydrogel prepared by the invention has good anti-inflammatory effect, good moisturizing effect, growth promotion, healing promotion, good repair effect on damaged skin barriers after medical and artistic works, high repair efficiency and lasting effect.
(3) By adopting the preparation method of the invention, electron beam irradiation sterilization is utilized, and the use safety is greatly improved while the biological activity of the functional components is ensured.
Detailed Description
In order to better understand the technical content of the invention, specific examples are provided below to further illustrate the invention.
The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified.
The materials, reagents and the like used in the examples of the present invention can be obtained commercially without specific description.
Examples 1 to 3
1 proportion of ingredients
Serial number | Components | Example 1(g) | Example 2(g) | Example 3(g) |
1 | Hyaluronic acid | 18 | 15 | 20 |
2 | Sodium alginate | 12 | 15 | 10 |
3 | Glycerol | 8 | 7 | 10 |
4 | Trehalose | 10 | 12 | 8 |
8 | Epsilon-polylysine | 4 | 5 | 3 |
5 | Citronella essential oil | 5 | 4 | 6 |
6 | Valerian essential oil | 7 | 8 | 5 |
7 | Citrus aurantium extract | 11 | 9 | 13 |
9 | Extract of kumquat | 12 | 10 | 13 |
10 | Mussel-like mucin | 13 | 15 | 12 |
2 preparation method
2.1 preparation of starting materials
(1) Preparing citronella essential oil: taking lemongrass powder, and adopting supercritical CO2Extracting with an extractor under 19MPa at 60 deg.C for 30min to obtain citronella essential oil.
(2) The preparation method of the valerian essential oil comprises the following steps: taking rhizoma et radix Valerianae powder, and extracting with supercritical CO2Extracting with an extractor under 23MPa at 45 deg.C for 60min to obtain rhizoma et radix Valerianae essential oil.
(3) The preparation method of the bitter orange extract comprises the following steps: taking bitter orange powder, wherein the ratio of the raw materials to the liquid is 1 kg: adding distilled water 5L, placing in microwave treatment with power of 28kW for 30min, placing in steam distillation for extraction, collecting distillate, extracting with diethyl ether, collecting extract, filtering, concentrating the filtrate by rotary evaporation, and vacuum drying at 45 deg.C for 30min to obtain Citrus aurantium L.
(4) The preparation method of the green orange extract comprises the following steps: taking green tangerine peel powder, and mixing the raw materials according to a feed-liquid ratio of 1 kg: adding 70 wt% ethanol solution into 8L, shaking at 300rpm and 55 deg.C for 1.5h, centrifuging, collecting supernatant, filtering, concentrating, and drying to obtain pericarpium Citri Tangerinae extract.
2.2 hydrogel preparation
Preparing distilled water according to the feed liquid mass ratio of 1:1, adding the bitter orange extract and the kumquat extract into one third of the distilled water, and stirring and mixing uniformly to obtain a mixed solution; slowly adding citronella essential oil and valerian essential oil into the mixed solution under stirring, and then adding mussel-like mucin under stirring; and finally, adding the balance of distilled water, hyaluronic acid, sodium alginate, glycerol, trehalose and epsilon-polylysine, stirring for 24 hours at 50 ℃, freeze-drying, sterilizing by adopting electron beam irradiation, and preparing the target hydrogel with the irradiation dose of 20 kGy.
Comparative example 1-this comparative example differs from example 1 mainly in that the mussel-like mucin is replaced with an equal amount of mussel mucin. The other components are in accordance with example 1.
Comparative example 2-this comparative example differs from example 1 mainly in that the citronella essential oil is replaced with an equal amount of basil (OCIMUM BASILICUM) oil. The other components are in accordance with example 1.
Comparative example 3-this comparative example differs from example 1 mainly in that the valerian essential oils are replaced by equal amounts of lavender (lavandula angustifolia) oil. The other components are in accordance with example 1.
Comparative example 4-this comparative example differs from example 1 mainly in that the citrus aurantium extract was replaced by an equal amount of rose (rosaugosa) flower extract. The other components are in accordance with example 1.
Comparative example 5-this comparative example differs from example 1 mainly in that the lime extract is replaced with an equal amount of citrus (citrus reticulata) peel extract. The other components are in accordance with example 1.
Comparative example 6-this comparative example differs from example 1 mainly in the different raw material ratios:
first, mouse test
Test method 1
Healthy mice were selected and randomly divided into control and administration groups of 1 to 9, 10 mice per group, and were raised under the same environment for 7 days. The method comprises the steps of shaving and removing hairs on two sides of the back of a mouse, exposing the skin on two sides of the back of the mouse, irradiating the exposed skin on the left side of the back of the mouse by using a 2940nm erbium laser therapeutic apparatus, immediately smearing 1mg/kg of hydrogel on administration groups 1-9 (the administration groups 1-9 are prepared into the hydrogels according to examples 1-3 and comparative examples 1-6 respectively) after irradiation is finished, not administrating and smearing the hydrogel with the same amount of pure water on a control group after irradiation, then breeding the mouse under a proper condition, and observing and recording the skin change of the laser irradiation part of the mouse on the 2 nd day. Irradiation was performed every 7 days for 4 weeks. After 4 weeks, irradiation was stopped, the mice were fixed upside down, the skin and artery of the neck were cut off, the arterial blood of the neck was taken out with a 10mL centrifuge tube, left for 2h at 3000rpm, and centrifuged for 10 min. Collecting the upper layer serum, and freezing for storage. And respectively detecting IL-6, INF-gamma or TNF-alpha of serum according to the detection instruction of the kit.
2 results of
TABLE 1 in vivo inflammatory factors in mice
IFN-γ(pg/ml) | TNF-α(ng/ml) | IL-6(pg/ml) | |
Control group | 154.0±14.2 | 86.9±10.3 | 27.1±4.2 |
Example 1 | 14.1±3.3 | 25.2±2.5 | 8.3±1.2 |
Example 2 | 15.6±3.6 | 28.5±2.3 | 8.6±1.6 |
Example 3 | 15.2±3.7 | 27.9±2.1 | 8.5±1.5 |
Comparative example 1 | 19.0±4.3 | 32.3±3.8 | 11.2±1.7 |
Comparative example 2 | 17.9±4.8 | 30.7±3.3 | 10.1±1.8 |
Comparative example 3 | 17.3±4.7 | 31.2±3.4 | 9.3±1.5 |
Comparative example 4 | 17.1±4.5 | 30.3±3.9 | 9.8±1.8 |
Comparative example 5 | 18.2±5.3 | 31.2±3.7 | 10.8±1.9 |
Comparative example 6 | 16.7±4.2 | 29.9±3.6 | 9.1±1.4 |
The results show that compared with the control group, the administration groups 1 to 9 effectively reduce the serum IL-6, INF-gamma or TNF-alpha level after the laser surgery, and have obvious difference. Among them, the administration groups 1 to 3 (examples 1 to 3) were significantly superior to the administration groups 4 to 9 (comparative examples 1 to 6).
The preparation method comprises the steps of adjusting and adding mussel mucin in a comparative example 1, adjusting and adding basil (Ocimum BASILICUM) oil in a comparative example 2, adjusting and adding lavender (Lavandula angustifolia) oil in a comparative example 3, adjusting and adding rose (Rosa rugosa) flower extract in a comparative example 4, adjusting and adding citrus (Citrus reticulata) peel extract in a comparative example 5, wherein the effects are obviously reduced, and the preparation method shows that the mussel mucin-like protein is combined with the citronella essential oil, the valerian essential oil, the citrus aurantium flower extract and the citrus reticulata extract to prepare the hydrogel with better effect. In addition, the comparative example 6 reduces the consumption of mussel-like mucin, the orange extract, the bitter orange extract and the like, increases the consumption of citronella essential oil, valerian essential oil and the like, and reduces the effect, thereby showing that the product effect is improved by adopting the raw materials in the proportion of the invention.
Second, clinical effects
1, basic data: volunteers after laser speckle removal were collected and randomly grouped into groups of 30 individuals, study groups 1-3 used the hydrogels of examples 1-3, respectively, all volunteers were female and aged 40-50 years. The patients in each group were comparable and the differences were not statistically significant (P > 0.05).
2 inclusion criteria:
1) the total score of the lactic acid stimulation test after the laser speckle removing operation is more than or equal to 2 points;
2) no serious liver and kidney function; patients with systemic diseases such as lesions and immunological abnormality;
3) the face is not treated by medicaments such as hormone and the like, other cosmetic treatments and treatments which may influence the result within 3 months;
4) those without hypersensitive constitution;
5) the patients were voluntarily in the trial, and were followed by the physician's advice.
3 exclusion criteria:
(1) those known to be allergic to the ingredients of the product;
(2) pregnant or lactating women;
(3) those with significant infection in the treated area;
(4) those who have used hormones or immunosuppressive drugs within 3 months.
(5) Patients suffering from mental diseases or being unable to cooperate with other factors.
4, a treatment method: after the face is cleaned before use, the hydrogel is uniformly smeared on the face, and the hydrogel is washed after being statically smeared for 15-20 minutes. The application is continued for 7 days, and the repairing condition is observed.
5 determination of therapeutic Effect
5.1 evaluation of skin damage improvement:
normal skin: the skin has no symptoms of erythema, pruritus, dryness, desquamation and the like;
mild damage: the skin is slightly dry and itchy, and scales, red spots and pimples are not obvious;
moderate impairment: moderate dryness of the skin with redness of scales and a few papules;
severe damage: the skin is dry, has red spots and obvious pruritus, has more scales and has obvious pimple.
5.2 lactic acid stimulation test: the lactic acid stimulation test is an evaluation method for determining sensitive skin.
The method comprises the following steps: after face cleaning, 50 mul of 10% lactic acid solution is smeared on the nasolabial folds and any side of cheeks and evaluated at 2.5min and 5min respectively, 0 is no stabbing pain, 1 is mild stabbing pain, 2 is moderate stabbing pain, 3 is severe stabbing pain, and the lactic acid stabbing pain reaction is positive when the sum of the two fractions is more than or equal to 3. Note that the scores before and after treatment were recorded.
5.3 detection of TEWL value: TEWL refers to the facial transdermal water loss and the water content of the stratum corneum, the lower the value, the higher the value of the water content of the stratum corneum, the better the barrier function of the skin; otherwise, the worse. TEWL value: healthy state (0-15), sub-healthy state (15-25), disease state (> 25).
6, adverse reaction: regular follow-up is carried out, and whether adverse reactions and conditions such as pruritus, erythema, papulopustule and the like occur or not are recorded.
7 results
TABLE 2 hydrogel repair 7 days later
The results show that the hydrogel in the examples 1-3 has high skin damage improvement rate after repair, the positive rate of the lactic acid sting test is obviously reduced, the TEWL value is at a lower level, and the water content of the horny layer is high.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (8)
1. The hydrogel for repairing damaged skin barrier after medical and art is characterized by comprising the following raw materials in parts by weight: 15-20 parts of hyaluronic acid, 10-15 parts of sodium alginate, 5-10 parts of glycerol, 8-12 parts of trehalose, 3-5 parts of epsilon-polylysine, 4-6 parts of citronella essential oil, 5-8 parts of valerian essential oil, 9-13 parts of citrus aurantium extract, 10-13 parts of green tangerine extract and 12-15 parts of mussel-like mucin.
2. The hydrogel for repairing damaged skin barrier after medical and art according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 18 parts of hyaluronic acid, 12 parts of sodium alginate, 8 parts of glycerol, 10 parts of trehalose, 4 parts of epsilon-polylysine, 5 parts of citronella essential oil, 7 parts of valerian essential oil, 11 parts of citrus aurantium extract, 12 parts of green tangerine extract and 13 parts of mussel-like mucin.
3. The hydrogel for repairing damaged skin barrier after medical arts according to claim 1, wherein the citronella essential oil is prepared by a method comprising: taking lemongrass powder, and adopting supercritical CO2Extracting with an extractor under 19MPa at 60 deg.C for 30min to obtain citronella essential oil.
4. The hydrogel for post-art repair of skin barrier damage according to claim 1, wherein the valerian essential oil is prepared by a process comprising: taking rhizoma et radix Valerianae powder, and extracting with supercritical CO2Extracting with an extractor under 23MPa at 45 deg.C for 60min to obtain rhizoma et radix Valerianae essential oil.
5. The hydrogel for repairing damaged skin barrier after medical and art according to claim 1, wherein the bitter citrus aurantium extract is prepared by the following steps: taking bitter orange powder, wherein the ratio of the raw materials to the liquid is 1 kg: adding distilled water 5L, placing in a microwave treatment with power of 28kW for 30min, placing in steam distillation for extraction, collecting distillate, extracting with diethyl ether, collecting extract, filtering, rotary-steaming the filtrate, and vacuum drying at 45 deg.C for 30min to obtain Citrus aurantium L.
6. The hydrogel for post-art repair of skin barrier damage according to claim 1, wherein the kumquat extract is prepared by a method comprising: taking green tangerine peel powder, and mixing the raw materials according to a feed-liquid ratio of 1 kg: adding 70 wt% ethanol solution into 8L, shaking at 300rpm and 55 deg.C for 1.5h, centrifuging, collecting supernatant, filtering, concentrating, and drying to obtain pericarpium Citri Tangerinae extract.
7. The method for producing a hydrogel according to any one of claims 1 to 6, comprising the steps of: preparing distilled water according to the feed liquid mass ratio of 1:1, adding the bitter orange extract and the kumquat extract into one third of the distilled water, and stirring and mixing to obtain a mixed solution; adding citronella essential oil and valerian essential oil into the mixed solution under stirring, and then adding mussel-like mucin; and finally, adding the balance of distilled water, hyaluronic acid, sodium alginate, glycerol, trehalose and epsilon-polylysine, stirring for 22-28h at the temperature of 45-55 ℃, freeze-drying, and sterilizing by adopting electron beam irradiation to prepare the target hydrogel.
8. The method for producing a hydrogel according to claim 7, wherein the irradiation dose for the electron beam irradiation sterilization is 20 kGy.
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