CN105193676A - Acne composition - Google Patents

Acne composition Download PDF

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Publication number
CN105193676A
CN105193676A CN 201510724911 CN201510724911A CN105193676A CN 105193676 A CN105193676 A CN 105193676A CN 201510724911 CN201510724911 CN 201510724911 CN 201510724911 A CN201510724911 A CN 201510724911A CN 105193676 A CN105193676 A CN 105193676A
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acne
rhegf
composition
extract
skin care
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CN 201510724911
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Chinese (zh)
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韦忠明
黄启斌
莫冬海
杨福春
包能创
秦芳
唐申秀
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桂林华诺威基因药业有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645Proteins of vegetable origin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/96Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70Biological properties of the composition as a whole

Abstract

The invention provides acne removing composition and a skin care product containing the same. The acne removing composition comprises rhEGF (recombinant human epidermal growth factor), hamamelis virginiana extract, hydrolyzed soy protein and scutellaria baicalensis extract. The composition accounts for 1%-2% of the weight of the skin care product. The weight content of rhEGF in the acne removing skin care product is only 1-10 mu g/ml and is far lower than the regular addition amount, the rhEGF is compounded with the hamamelis virginiana extract, the hydrolyzed soy protein and the scutellaria baicalensis extract to realize synergistic effect, so that pores can be dredged, grease secretion is balanced, overall repair is realized, the skin barrier function is improved, the wound healing time is shortened, scar formation is reduced, and acne is completely removed without scars.

Description

祛痘组合物 Acne composition

技术领域 FIELD

[0001] 本发明属于化妆品技术领域,具体涉及祛痘组合物。 [0001] The present invention belongs to the technical field of cosmetics, particularly relates to compositions acne.

背景技术 Background technique

[0002] 表皮生长因子(EGF)是一种多功能的细胞生长促进因子,具有广泛的促进细胞生长活性,加快人体皮肤细胞生长速度,促进皮肤新细胞生长繁殖,是影响皮肤健康的决定性因素。 [0002] Epidermal growth factor (EGF) is a multifunctional cell growth promoting factor, a wide range of activity to promote cell growth, accelerate the growth rate of human skin cells, promote new skin cell growth and reproduction, is the decisive factor affecting skin health. 然而随着年龄的增长以及环境的恶化,人体内EGF的含量逐渐减少,导致皮肤健康受损。 However, with age and deterioration of the environment, EGF content in the human body gradually decrease, resulting in damage to healthy skin. 天然EGF广泛存在于哺乳动物体内,其含量低,提取难度大,成本高,人们通常采用rhEGF替代天然EGF。 EGF naturally widely present in the mammal, the content thereof is low, extraction difficult, costly, it usually rhEGF replacing the natural EGF. rhEGF能刺激外胚rhEGF层和内胚层起源的各种细胞如角膜、上皮等, 使其增殖。 rhEGF rhEGF layer can stimulate ectodermal and endodermal origin such as corneal various cells, and other epithelial, proliferated. 它的生物学效应包括:1)促进低分子量化合物从细胞外主动运至细胞内,增加细胞的营养物质;2)活化糖酵解作用以增加呼吸代谢,能激活磷酸果糖激酶;3)刺激细胞外大分子的合成,如透明质酸和糖蛋白。 Its biological effects include: 1) low molecular weight compound to promote active transport into cells from the extracellular, increased nutrient cells; 2) to increase the activation of glycolysis respiratory metabolism, can activate phosphofructokinase; 3) cells were stimulated synthesis of extracellular macromolecules, such as glycoproteins and hyaluronic acid. 4)活化RNA和蛋白质的合成;5)促进DNA的合成; 6)促进细胞增殖促进机体一些物质如果酸、前列腺素的合成。 4) activation of RNA and protein synthesis; 5) promote the synthesis of DNA; 6) promote cell proliferation promoting material, if the body of some synthetic acids, prostaglandins. 这些生物效应表明,rhEGF可通过传导信号,引起细胞内一系列生化变化,启动与细胞分裂有关的基因,使静止细胞进入细胞分裂期,从而使细胞增殖。 These biological effects indicate, rhEGF through signal transduction, causing a series of biochemical changes in cells, cell division started related genes, so that resting cells to enter cell division, so that the cell proliferation. rhEGF能刺激肉芽组织的形成和促进肉芽组织的上皮化,还可调节胶原降解及更新,使胶原纤维以线性方式排列,防止结缔组织异常增生,故而有缩短创伤愈合时间以及减少疤痕形成的作用,对防止和护理痤疮有很好的效果。 rhEGF can stimulate granulation tissue formation and epithelialization promoting granulation tissue, collagen degradation and can also be adjusted to update the collagen fibers are arranged in a linear manner, to prevent the abnormal proliferation of connective tissue, and therefore have a role in wound healing shorten time and reduce scar formation, have a good effect on the prevention and treatment of acne. 现有技术中已出现含有rhEGF的护肤品,对祛痘等方面具有一定的积极意义。 Art skin care products contain rhEGF has occurred, it has some positive aspects such as acne. 由于外源rhEGF在渗透皮肤等过程中出现物理损失及失活,使得rhEGF在护肤品中的含量要远远超出人体内EGF浓度数倍甚至数百倍才能达到预期效果,经皮肤试验验证,护肤品中rhEGF的浓度为100yg/ ml时才能达到临床上可控制症状的效果,rhEGF的浓度为300yg/ml以上时,临床症状才开始好转。 Due to physical losses and deactivation of exogenous rhEGF appear to penetrate the skin and other processes, so that the content rhEGF in skin care products to human EGF concentration far beyond the body several times even hundreds of times to achieve the desired results, the experimental verification skin, skincare product concentration in rhEGF is 100yg / in order to achieve the desired effect can control the symptoms of clinical ml, the concentration of 300yg rhEGF time / more than ml, clinical symptoms began to improve. 护肤品中rhEGF的添加量过高,但效率低下,大大增加了生产成本。 Skin care products rhEGF added amount is too high, but low efficiency, greatly increasing the cost of production.

发明内容 SUMMARY

[0003] 本发明要解决的技术问题是提供祛痘组合物以及含有该祛痘组合物的护肤品,该护肤品中rhEGF添加量小,活性高。 [0003] The present invention is to solve the technical problem of providing a composition acne and acne comprising the skin care composition, the skin care products rhEGF add a small amount of high activity.

[0004] 本发明提供的技术方案是祛痘组合物,它是由rhEGF、北美金缕梅提取液、水解大豆蛋白和黄芩提取物组成。 [0004] aspect of the present invention is to provide acne composition is made rhEGF, witch hazel extract, hydrolyzed soy protein composition and Scutellaria root extract.

[0005] 水解大豆蛋白是大豆提取物,富含与呼吸链蛋白相似的肽,能显著提升皮肤视觉和感觉效果。 [0005] Soy protein is hydrolyzed soy extract enriched with similar peptide respiratory chain, can significantly improve skin feel and visual effects. 参数为:外观为透明液体,黄色,PH(20°C ) :4. 0~5. 0 ;折射率(20°C ): 1. 365 ~1. 385 ;密度(20°C ) :1. 06 ~I. 09g/cm3;蛋白含量(Lowry 法)1. 5 ~3. 5g/kg ;山梨酸钾含量% 〇. 10~〇. 16 ;苯甲酸钠含量% 0. 240~0. 30。 Parameters: Appearance transparent liquid, yellow, PH (20 ° C): 4 0 ~ 5 0; index of refraction (20 ° C):... 1. 365 ~ 1 385; Density (20 ° C): 1. . 06 ~ I 09g / cm3;.. protein (Lowry method) 1 5 ~ 3 5g / kg;..% potassium sorbate content of 16 billion square 10 ~;.% of sodium benzoate 0.240 ~ 030.

[0006] 黄苳提取物是将黄苳(Scutellaria baicalensis Georgi)的根粉碎,按lg: 10~ 20ml的比例加水,在70~90°C下回流提取3次,每次1~2h,合并提取液,浓缩至相对密度为I. 1~1. 2的浸膏,即为黄芩提取物。 [0006] Yellow paper cutters extract is yellow paper cutters (Scutellaria baicalensis Georgi) roots crushed by lg: ratio of 10 ~ 20ml of water was added, reflux was extracted three times at 70 ~ 90 ° C, each 1 ~ 2h, and the combined extracts solution, concentrated to the relative density of extract 1 I. ~ 1.2, namely Scutellaria root extract.

[0007] 北美金缕梅提取液,外观:无色透明液体;PH(10%水溶液):5~6. 5 ;折光率(20°C ) :1. 4160~I. 4200 ;相对密度(20°C ) :1. 03~I. 036。 [0007] witch hazel extract, Appearance: colorless transparent liquid; PH (10% solution): 5 to 65; Refractive index (20 ° C):... 1 4160 ~ I 4200; relative density (20 ° C):. 1 03 ~ I 036.. 北美金缕梅提取液肤感高度舒爽清新自然,可及时补充肌肤水分,易于吸收。 North American witch hazel extract skin feeling fresh and clean comfortable height, can replenish skin moisture, easy to absorb.

[0008] 以上述祛痘组合物总重计,各组分的重量百分比分别为:rhEGF 0. 01~0. 05%、 北美金缕梅提取液20~40 %、水解大豆蛋白35~50 %和黄芩提取物20~30 %。 [0008] In the above-described acne composition total weight, the weight percentages of the components are:. RhEGF 0. 01 ~ 0 05%, witch hazel extract 20% to 40%, hydrolyzed soy protein 35 - 50% Scutellaria root extract and 20 to 30%.

[0009] 上述组分的重量百分比分别为:rhEGF 0.03%、北美金缕梅提取液30%、水解大豆蛋白40 %和黄芩提取物29.97%。 [0009] The percentage by weight of the above components are: rhEGF 0.03%, witch hazel extract was 30%, 40% hydrolyzed soy protein and 29.97% Scutellaria root extract.

[0010] 本发明还提供了一种护肤品,含有上述祛痘组合物。 [0010] The present invention also provides a skin care composition containing the acne. 所述祛痘组合物在该护肤品中的重量含量为1~2%,优选为1. 5%。 The composition acne skincare the weight content is 1 to 2%, preferably 1.5%.

[0011] 所述护肤品为祛痘霜或祛痘乳液。 [0011] Acne is a skin care cream or lotion acne. 祛乳霜/乳液的常规配方: Remove cream / lotion conventional formula:

[0012] 祛痘组合物:1~2% ; [0012] Acne composition: 1 to 2%;

[0013] 乳化剂:0.5 ~10%; [0013] Emulsifier: 0.5 ~ 10%;

[0014] 润肤剂:5~40%; [0014] Emollients: 5 to 40%;

[0015] 赋型增稠剂:0• 1~10% ; [0015] forming thickener: 0 • 1 ~ 10%;

[0016] 保湿剂:5~30%; [0016] Humectant: 5 to 30%;

[0017] 防腐剂:常规量; [0017] Preservative: conventional amounts;

[0018] 抗氧化剂:常规量; [0018] Antioxidant: conventional amounts;

[0019] 去离子水:余量。 [0019] Deionized water: balance.

[0020] 所述的护肤品的制备方法为:先将护肤品中油相和水相进行初步乳化,调整该乳化体系的温度在35~40°C时,加入rhEGF、北美金缕梅提取液、水解大豆蛋白和黄芩提取物,体系经搅拌均匀,进一步降温检验合格出料。 [0020] The method for preparing skin care products are: first skincare oil phase and an aqueous phase and preliminarily emulsified, the emulsifying system of adjusting the temperature at 35 ~ 40 ° C, was added rhEGF, witch hazel extract, hydrolyzed soy protein and Scutellaria root extract, the system was stirred uniformly, to further cool the material inspection.

[0021] 与现有技术相比,本发明具有以下有益效果: [0021] Compared with the prior art, the present invention has the following advantages:

[0022] 1)水解大豆蛋白和黄芩提取物的肽键结构与rhEGF相似,肽键间极易发生交叉、 盘绕、组合物等空间位移反应,rhEGF被水解大豆蛋白和黄芩提取物的肽分子键环状包围, 保护了rhEGF空间结构,避免rhEGF失活,大大提高效率。 [0022] 1) hydrolyzed soy protein and Scutellaria root extract a peptide bond structure rhEGF was similar, easily crossover occurs between a peptide bond, coiled, spatial displacement composition and other reactions, rhEGF is hydrolyzed peptide molecule bonds soy protein and Scutellaria root extract of ring surrounds, protects rhEGF spatial structure, avoid rhEGF inactivation, greatly improving efficiency.

[0023] 2)北美金缕梅提取液和黄芩提取物能平衡油脂分泌、溶解角栓、抑制细菌增殖、修复瘢痕,促进祛痘成分经皮肤吸收,促进痘伤口愈合,使皮肤恢复正常细腻柔滑。 [0023] 2) witch hazel extract and Scutellaria root extract can balance oil secretion, dissolved angle plug, inhibit bacterial growth, repair scar ingredients absorbed through the skin to promote acne, pox promote wound healing, to restore normal skin smooth and delicate .

[0024] 3)北美金缕梅提取液、水解大豆蛋白和黄芩提取物是易被皮肤吸收,rhEGF与北美金缕梅提取液、水解大豆蛋白和黄芩提取物结合极易被皮肤吸收,减少渗透过程中的rhEGF损失。 [0024] 3) witch hazel extract, hydrolyzed soy protein and Scutellaria root extract is absorption through the skin, rhEGF and witch hazel extract, hydrolyzed soy protein binding and Scutellaria root extract can easily be absorbed by the skin, to reduce penetration rhEGF loss process.

[0025] 4)本发明的护肤品中rhEGF的重量含量仅为1~10 yg/ml,远远低于常规添加量,与北美金缕梅提取液、水解大豆蛋白和黄芩提取物产生协同作用,能疏通毛孔,平衡油脂分泌,全面修复并提高皮肤的屏障功能,缩短创伤愈合时间以及减少疤痕形成的作用,彻底祛除青春痘且不留痕。 [0025] 4) content by weight of skin care products of the present invention rhEGF only 1 ~ 10 yg / ml, far below the conventional addition amount, and witch hazel extract, hydrolyzed soy protein and Scutellaria root extract synergies can unclog pores, balance oil secretion, comprehensive repair and improve the barrier function of the skin, shortening wound healing time and reduce scarring effect, completely eliminate acne without leaving marks.

具体实施方式 Detailed ways

[0026] 以下具体实施例对本发明作进一步阐述,但不作为对本发明的限定。 [0026] The following specific embodiments of the present invention is further illustrated, but not limit the present invention.

[0027] 实施例1 [0027] Example 1

[0028] 祛痘组合物:rhEGF冻干粉0. 01 %、北美金缕梅提取液40 %、水解大豆蛋白35 %和黄芩提取物24. 99%。 [0028] Acne composition: rhEGF lyophilized powder 0.01%, 40% witch hazel extract, hydrolyzed soy protein and 35% Scutellaria root extract 24.99%.

[0029] 实施例2 [0029] Example 2

[0030] 祛痘组合物:rhEGF冻干粉0. 05 %、北美金缕梅提取液20 %、水解大豆蛋白50 %和黄芩提取物29. 95%。 [0030] Acne composition: rhEGF lyophilized powder 0.05%, 20% witch hazel extract, hydrolyzed soy protein and 50% Scutellaria root extract 29.95%.

[0031] 实施例3 [0031] Example 3

[0032]祛痘组合物:rhEGF冻干粉0. 03 %、北美金缕梅提取液30 %、水解大豆蛋白40 %和黄芩提取物29. 97%。 [0032] Acne composition: rhEGF lyophilized powder 0.03%, 30% witch hazel extract, hydrolyzed soy protein and 40% Scutellaria root extract 29.97%.

[0033] 实施例4 [0033] Example 4

[0034] 祛痘霜的配方如下(w% ): [0034] The following formulation acne cream (w%):

[0035] 祛痘组合物(实施例1的祛痘组合物):1. 5% [0035] The composition of acne (acne composition of Example 1): 15%

[0036] 甘油硬脂酸酯:3% [0036] Glycerol stearate: 3%

[0037] 鲸蜡硬脂醇:5% [0037] Cetearyl alcohol: 5%

[0038] 甘油:10% [0038] Glycerol: 10%

[0039] 丙二醇:10% [0039] Propylene glycol: 10%

[0040] 氢化聚葵烯:5% [0040] The hydrogenated poly decene: 5%

[0041] 鲸蜡醇聚醚-20 :1% [0041] ceteth-20: 1%

[0042] 椰油醇硫酸酯钠:0• 5% [0042] ester sodium coconut alcohol: 0 • 5%

[0043] 羟乙基纤维素:0.7% [0043] Hydroxyethyl cellulose: 0.7%

[0044] 防腐剂:适量[0045] 香精:适量[0046] 去离子水:余量。 [0044] Preservative: qs [0045] Flavor: qs [0046] Deionized water: balance.

[0047] 制备方法: [0047] Preparation:

[0048] 1)在油相处理罐内,将油相物料(丙二醇、鲸蜡硬脂醇、甘油硬脂酸酯、氢化聚葵烯)投入釜内,同时开动搅拌器,加热至92~98°C,同时开动搅拌器,使物料完全熔化; [0048] 1) an oil phase in the process tank, the oil phase materials (propylene glycol, cetearyl alcohol, glyceryl stearate, hydrogenated poly decene) charged into the autoclave agitator was started at the same time, heated to 92 ~ 98 ° C, while the stirrer was started, the material is completely melted;

[0049] 2)在水相预处理罐中,将甘油全部投入釜内,开动搅拌,并将羟乙基纤维素以粉末形式缓慢投入釜内,使其充分分散,然后将其他水相(水、鲸蜡醇聚醚-20、椰油醇硫酸酯钠)投入釜内,加热至92~98°C,搅拌至均匀; [0049] 2) in an aqueous pretreatment tank, all of the glycerol into the autoclave, stirring was started, and hydroxyethylcellulose in a powder form was slowly charged into the autoclave, fully dispersed, and then the other water phase (water , ceteth-20, coconut alcohol sulfates, sodium) into the autoclave and heated to 92 ~ 98 ° C, stirred until homogeneous;

[0050] 3)经过滤的油相吸入进过预热的乳化罐内,后吸入水相,并以此启动刮板搅拌、快速搅拌、均质器(启动乳化釜快速搅拌和均质器约10~12分钟),此时乳化釜内温度不应低于85°C。 [0050] 3) The oil phase was filtered through pre-emulsion into the suction tank, the suction aqueous phase, and thus start the stirring blade, with rapid stirring, a homogenizer (start with rapid stirring and emulsifying tank homogenizer about 10 to 12 minutes), then emulsifying pot temperature should not be below 85 ° C. 进行真空乳化后,保温搅拌10~15分钟后,再开动冷却装置降温。 After vacuum emulsification, incubated for 10 to 15 minutes, and then activate the cooling means to cool.

[0051] 4)当温度降到55~60°C时,加入香精,温度降到35~40°C,加入rhEGF、北美金缕梅提取液、水解大豆蛋白和黄芩提取物,防腐剂,继续搅拌,当温度继续降至30°C时,检验合格后出料。 [0051] 4) When the temperature dropped to 55 ~ 60 ° C, flavor was added, the temperature dropped to 35 ~ 40 ° C, was added rhEGF, witch hazel extract, hydrolyzed soy protein and Scutellaria root extract, the preservative, continued stirring, when the temperature dropped to continue 30 ° C, the discharge inspection.

[0052] 实施例5 [0052] Example 5

[0053] 本实施例的祛痘霜与实施例4的配方和制备方法一致,仅祛痘组合物采用实施例2的祛痘组合物。 [0053] The present embodiment is consistent acne cream formulation and preparation method described in Example 4, only the compositions employed Acne Acne composition of Example 2.

[0054] 实施例6 [0054] Example 6

[0055] 本实施例的祛痘霜与实施例4的配方和制备方法一致,仅祛痘组合物采用实施例3的祛痘组合物。 [0055] The present embodiment is consistent with acne cream formula and preparation method of Example 4, the composition using only acne acne composition of Example 3.

[0056]对照例1 [0056] Comparative Example 1

[0057] 祛痘霜的配方如下(w% ): [0057] The following formulation acne cream (w%):

[0058] rhEGF 冻干粉:0• 01 % [0058] rhEGF freeze-dried powder: 0 • 01%

[0059] 甘油硬脂酸酯:3% [0059] Glycerol stearate: 3%

[0060] 鲸蜡硬脂醇:5% [0060] Cetearyl alcohol: 5%

[0061] 甘油:10% [0061] Glycerol: 10%

[0062] 丙二醇:10% [0062] Propylene glycol: 10%

[0063] 氢化聚葵烯:5% [0063] The hydrogenated poly decene: 5%

[0064] 鲸蜡醇聚醚-20 :1 % [0064] ceteth-20: 1%

[0065] 椰油醇硫酸酯钠:0• 5% [0065] ester sodium coconut alcohol: 0 • 5%

[0066] 羟乙基纤维素:0.7% [0066] Hydroxyethyl cellulose: 0.7%

[0067] 防腐剂:适量 [0067] Preservatives: moderate

[0068] 香精:适量 [0068] Flavor: moderate

[0069] 去离子水:余量。 [0069] Deionized water: balance.

[0070] 其制备方法与实施例4相同。 [0070] 4 the same preparation method as in Example.

[0071] 对照例2 [0071] Comparative Example 2

[0072] 祛痘霜的配方如下(w% ): [0072] The following formulation acne cream (w%):

[0073] rhEGF 冻干粉:0• 01 % [0073] rhEGF freeze-dried powder: 0 • 01%

[0074] 北美金缕梅提取液:0• 3% [0074] witch hazel extract: 0 • 3%

[0075] 甘油硬脂酸酯:3% [0075] Glycerol stearate: 3%

[0076] 鲸蜡硬脂醇:5% [0076] Cetearyl alcohol: 5%

[0077] 甘油:10% [0077] Glycerol: 10%

[0078] 丙二醇:10% [0078] Propylene glycol: 10%

[0079] 氢化聚葵烯:5% [0079] The hydrogenated poly decene: 5%

[0080] 鲸蜡醇聚醚-20 :1 % [0080] ceteth-20: 1%

[0081] 椰油醇硫酸酯钠:0. 5% [0081] ester sodium coconut alcohol: 05%

[0082] 羟乙基纤维素:0.7% [0082] Hydroxyethyl cellulose: 0.7%

[0083] 防腐剂:适量 [0083] Preservatives: moderate

[0084] 香精:适量 [0084] Flavor: moderate

[0085] 去离子水:余量。 [0085] Deionized water: balance.

[0086] 其制备方法与实施例4相同。 [0086] 4 the same preparation method as in Example.

[0087] 对照例3 [0087] Comparative Example 3

[0088] 祛痘霜的配方如下(w% ): [0088] The following formulation acne cream (w%):

[0089] rhEGF 冻干粉:0• 01 % [0089] rhEGF freeze-dried powder: 0 • 01%

[0090] 北美金缕梅提取液:0• 3% [0090] witch hazel extract: 0 • 3%

[0091] 水解大豆蛋白:0.5% [0091] Hydrolyzed Soy Protein: 0.5%

[0092] 甘油硬脂酸酯:3% [0092] Glycerol stearate: 3%

[0093] 鲸蜡硬脂醇:5% [0093] Cetearyl alcohol: 5%

[0094] 甘油:10% [0094] Glycerol: 10%

[0095] 丙二醇:10% [0095] Propylene glycol: 10%

[0096] 氢化聚葵烯:5% [0096] The hydrogenated poly decene: 5%

[0097] 鲸蜡醇聚醚-20 :1 % [0097] ceteth-20: 1%

[0098] 椰油醇硫酸酯钠:0• 5% [0098] ester sodium coconut alcohol: 0 • 5%

[0099] 羟乙基纤维素:0.7% [0099] Hydroxyethyl cellulose: 0.7%

[0100] 防腐剂:适量[0101] 香精:适量 [0100] Preservative: qs [0101] Flavor: moderate

[0102] 去离子水:余量。 [0102] Deionized water: balance.

[0103] 其制备方法与实施例4相同。 [0103] 4 the same preparation method as in Example.

[0104] 对照例4 [0104] Comparative Example 4

[0105] 祛痘霜的配方如下(w% ): [0105] The following formulation acne cream (w%):

[0106] rhEGF 冻干粉:0• 01 % [0106] rhEGF freeze-dried powder: 0 • 01%

[0107] 北美金缕梅提取液:0. 3% [0107] witch hazel extract: 0 3%

[0108] 黄芩提取物:0.3% [0108] Scutellaria root extract: 0.3%

[0109] 甘油硬脂酸酯:3% [0109] Glycerol stearate: 3%

[0110] 鲸蜡硬脂醇:5% [0110] Cetearyl alcohol: 5%

[0111] 甘油:10% [0111] Glycerol: 10%

[0112] 丙二醇:10% [0112] Propylene glycol: 10%

[0113] 氢化聚葵烯:5% [0113] The hydrogenated poly decene: 5%

[0114] 鲸蜡醇聚醚-20 :1% [0114] ceteth-20: 1%

[0115] 椰油醇硫酸酯钠:0• 5% [0115] ester sodium coconut alcohol: 0 • 5%

[0116] 羟乙基纤维素:0.7% [0116] Hydroxyethyl cellulose: 0.7%

[0117] 防腐剂:适量 [0117] Preservatives: moderate

[0118] 香精:适量 [0118] Flavor: moderate

[0119] 去离子水:余量。 [0119] Deionized water: balance.

[0120] 其制备方法与实施例4相同。 [0120] 4 the same preparation method as in Example.

[0121] 实施例7 [0121] Example 7

[0122] 祛痘乳液配方如下(w% ): [0122] Acne Emulsion following formulation (w%):

[0123] 祛痘组合物(实施例2的祛痘组合物):1% [0123] The composition of acne (acne composition of Example 2): 1%

[0124] 甘油硬脂酸酯1.5% [0124] Glycerol monostearate 1.5%

[0125] 鲸蜡硬脂醇1 % [0125] Cetearyl alcohol 1%

[0126] 甘油10% [0126] Glycerol 10%

[0127] 丙二醇10% [0127] Propylene glycol 10%

[0128] 氢化聚葵烯5% [0128] 5% of hydrogenated poly-decene

[0129] 鲸蜡醇聚醚-201 % [0129] Ceteth -201%

[0130] 椰油醇硫酸酯钠0. 5 % [0130] ester sodium coco alcohol sulfate 0.5%

[0131] 羟乙基纤维素0.3% [0131] Hydroxyethyl cellulose 0.3%

[0132] 防腐剂适量 [0132] Preservatives qs

[0133] 香精适量 [0133] Perfume Appropriate amount

[0134] 去离子水余量。 [0134] Deionized water balance.

[0135] 制备方法: [0135] Preparation:

[0136] 1)在油相预处理罐内,将油相物料(丙二醇、鲸蜡硬脂醇、甘油硬脂酸酯、氢化聚葵烯)投入釜内,同时开动搅拌器,加热至92~98°C,同时开动搅拌器,使物料完全熔化; 在水相预处理罐内,将配方中的甘油全部投入釜内,开动搅拌,并将羟乙基纤维素以粉末形式缓慢撒入釜内,使其充分分散,然后将水相中其他物料(去离子水、鲸蜡醇聚醚-20、椰油醇硫酸酯钠)投入釜内,加热至92~98°C,搅拌至均匀; [0136] 1) an oil phase pretreatment tank, the oil phase materials (propylene glycol, cetearyl alcohol, glyceryl stearate, hydrogenated poly decene) charged into the autoclave agitator was started at the same time, heated to 92 ~ 98 ° C, while the stirrer was started, the material is completely melted; pre-treatment tank in the water phase, all of the formulations glycerol into the autoclave, stirring was started, and the hydroxyethylcellulose was slowly sprinkled in powder form in the autoclave , fully dispersed, and then other materials in the aqueous phase (deionized water, ceteth-20, coconut alcohol sulfate sodium) into the autoclave and heated to 92 ~ 98 ° C, stirred until homogeneous;

[0137] 2)经过滤的油相物吸入进过预热的乳化罐内,后吸入水相物,并依次启动刮板搅拌、快速搅拌、均质器(启动乳化釜快速搅拌和均质器约10~12分钟),此时乳化釜内温度不应低于85°C。 [0137] 2) The oil phase was filtered through pre-emulsion into the suction tank, the suction aqueous phase was stirred and successively start blade, with rapid stirring, a homogenizer (start with rapid stirring and emulsifying a homogenizer tank from about 10 to 12 minutes), when the emulsion reactor temperature should not be below 85 ° C. 进行真空乳化后,保温搅拌10~15分钟后,再开动冷却装置降温; After vacuum emulsification, incubated for 10 to 15 minutes, and then activate the cooling means to cool;

[0138] 3)当温度降到55~60°C时,加入添加相(香精),搅拌,继续降温到35~40°C 时,加入rhEGF、北美金缕梅提取液、水解大豆蛋白和黄芩提取物,防腐剂,搅拌,继续降温至30 °C时,检验合格后出料。 [0138] 3) When the temperature dropped to 55 ~ 60 ° C, added added phase (fragrance), when the stirring, cooling continued to 35 ~ 40 ° C, was added rhEGF, witch hazel extract, hydrolyzed soy protein and Scutellaria when extracts, preservatives, stirring and continue cooling to 30 ° C, the discharge inspection.

[0139] 实施例8 [0139] Example 8

[0140] 本实施例的祛痘乳液与实施例7的配方和制备方法一致,除祛痘组合物的用量为2%〇 [0140] Acne emulsion of the present embodiment corresponds to the exemplary embodiment of the formulation and method of Example 7, except acne composition is used in an amount of 2% billion

[0141] 为验证本发明祛痘护肤品的祛痘效果,现开展以下实验。 [0141] To verify the effect of acne acne skin care products of the present invention, the following experiment was carried out now.

[0142] 选取轻、中度面部寻常青春痘(参考PillSburv及国际改良痤疮粉剂法诊断中轻度痤疮者)志愿者共70名,其中男38名,女32人;年龄在17~35岁之间,平均年龄28. 3 岁;病程4周~7年,平均3. 5年,在涂抹该护肤品的前2周,未使用糖皮质类激素、维A酸类和抗生素类药物,无高血脂及肝肾功能异常,紧致酗酒,避免强烈阳光或紫外线过度照射。 [0142] Select mild to moderate facial acne vulgaris (improved diagnostic reference PillSburv and international law mild acne acne powder were) a total of 70 volunteers, 38 male, 32 female; aged 17 to 35 years old between, average age 28.3 years; duration of 4 weeks to 7 years, an average of 3.5 years, the applied skin care products in the first 2 weeks of not using glucocorticoid hormone, vitamin a acids and antibiotics, no high lipids, liver and kidney dysfunction, alcoholism tight, avoid strong sunlight or excessive ultraviolet radiation.

[0143] 将上述70名志愿者随机分为7组,每组10人,分别为实验组1~3和对照组1~ 4。 [0143] The above 70 volunteers were randomly divided into 7 groups, 10 persons each, respectively, the experimental group and the control group 1-3 1-4. 实验组1~3分别使用本发明实施例1~3的祛痘,对照组1~4分别使用对照例1~ 4的祛痘霜。 1 to 3 in the experimental group were used according to the present invention, Examples 1 to 3, acne embodiment, the control group having 1 to 4 were used for Comparative Example 1 to 4, acne cream. 受试者以温水清洁患部皮肤病擦开后,每日早晚涂抹对应样品1次,使用期间停用其他药物或护肤品,为期4周。 After subjects affected dermatological wipe clean with warm water to open, applied twice a day corresponding to the sample 1, to disable the other skin care products during the use of the drug or, for 4 weeks. 在治疗前以及治疗后,分别对受试者面部炎性损害总数(炎性丘疹和脓包总和)、非炎性损害总和(白头粉刺和黑头粉刺的总和)计数,同时详细记录使用后的不良反应。 Prior to treatment and after treatment, respectively, subject to the total number of facial inflammatory lesions (papules and pustules inflammatory sum), the sum of non-inflammatory lesions (whiteheads and blackheads sum) counting, detailed records using the adverse reactions .

[0144] 评价标准: [0144] Evaluation Criteria:

[0145] 基愈:疗效指数彡90%; [0145] more groups: San efficacy index 90%;

[0146] 显效:60%彡疗效指数< 90% ; [0146] markedly: San efficacy index of 60% <90%;

[0147] 进步:20%彡疗效指数< 60% ; [0147] Progress: San efficacy index of 20% <60%;

[0148] 无效:疗效指数<20%。 [0148] Invalid: efficacy index <20%.

[0149] 疗效指数=(治疗前总皮损数-治疗后总皮损数)/治疗前总皮损数X 100% ; [0149] Efficacy index = (total number of lesions before treatment - the total number of lesions after treatment) / total number of lesions before treatment X 100%;

[0150] 有效率=(基愈人数+显效人数)/总人数X 100%。 [0150] efficiency = (number of groups markedly more + number) / total number X 100%.

[0151] [0151]

Figure CN105193676AD00081

Figure CN105193676AD00091

Claims (7)

  1. 1. 祛痘组合物,其特征在于:它是由rhEGF、北美金缕梅提取液、水解大豆蛋白和黄芩提取物组成。 1. acne compositions, characterized in that: it is made rhEGF, witch hazel extract, hydrolyzed soy protein composition and Scutellaria root extract.
  2. 2. 根据权利要求1所述的祛痘组合物,其特征在于:以该组合物总重计,各组分的重量百分比分别为:rhEGF0.Ol~0. 05%、北美金缕梅提取液20~40%、水解大豆蛋白35~ 50 %和黄芩提取物20~30 %。 2. The composition of claim acne according to claim 1, wherein: of the composition total weight, the weight percentages of the components are:. RhEGF0.Ol ~ 0 05%, witch hazel extract 20 to 40%, hydrolyzed soy protein and 35% to 50% Scutellaria root extract 20% to 30%.
  3. 3. 根据权利要求2所述的祛痘组合物,其特征在于:各组分的重量百分比分别为: rhEGF0. 03%、北美金缕梅提取液30%、水解大豆蛋白40 %和黄芩提取物29. 97%。 Acne composition according to claim claim 2, wherein: the weight percentages of each component are:. RhEGF0 03%, 30% witch hazel extract, hydrolyzed soy protein and 40% Scutellaria root extract 29.97%.
  4. 4. 一种护肤品,其特征在于:含有权利要求1~3中任一项所述的祛痘组合物。 A skin care, characterized in that: contains Claim acne composition of any one of claims 1 to 3.
  5. 5. 根据权利要求4所述的护肤品,其特征在于:所述祛痘组合物在该护肤品中的重量含量为1~2%。 Skin care products according to claim 4, wherein: the weight content of the acne skin care composition is from 1 to 2%.
  6. 6. 根据权利要求5所述的护肤品,其特征在于:所述祛痘组合物在该护肤品中的重量含量为1. 5%。 Skin care products according to claim 5, wherein: the weight content of the acne skincare composition in the range 1.5%.
  7. 7. 根据权利要求4~6中任一项所述的护肤品,其特征在于:其为祛痘霜或祛痘乳液。 According to claim 4 to 6, any one of skin care products, characterized in that: it is acne acne cream or lotion.
CN 201510724911 2015-10-29 2015-10-29 Acne composition CN105193676A (en)

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CN1337269A (en) * 2000-07-13 2002-02-27 约翰逊及约翰逊太平洋控股有限公司 Local therapeutic method for skin
CN102406581A (en) * 2011-11-28 2012-04-11 天津郁美净集团有限公司 Skin protecting composite with function of tightening skin
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