CN104069034A - Skin-protecting composition and cosmetics with oil-controlling and pore-shrinking effects - Google Patents
Skin-protecting composition and cosmetics with oil-controlling and pore-shrinking effects Download PDFInfo
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Abstract
The invention provides a skin-protecting composition and cosmetics with oil-controlling and pore-shrinking effects. The composition is prepared from Chinese violet extract, rhizoma anemarrhenae extract and rheum officinale extract in a weight ratio of 4:2-4:1-5 based on traditional Chinese medicine raw materials Chinese violet, rhizoma anemarrhenae and rheum officinale. The composition can play a synergetic effect in inhibiting 5 alpha reductase, resisting inflammation, inhibiting grease secretion and shrinking pores, and can be applied to skin-protecting and washing cosmetics, so that a product has the effects of controlling oil and shrinking pores.
Description
Technical field
The invention relates to a kind of skin care compositions and cosmetics with control oil, pore refining effect, particularly about a kind of skin care compositions with control oil, pore refining effect that comprises Herba Violae extract, Rhizoma Anemarrhenae extract, Radix Et Rhizoma Rhei extract, and the cosmetics that comprise said composition.
Background technology
Along with the age increase, the problem such as social pressure is excessive, environmental pollution, computer radiate is more and more serious, skin is caused to many harmful effects thereupon, the people of mixed skin is more and more, except some are born mixed skin, some people becomes mixed skin along with pressure, before also having, be neutral skin or oily skin, also can be along with the age, environment etc. becomes mixed skin.
Sebum is by the sebaceous gland Hemapoiesis of skin the inside, is then secreted into the oil of skin surface.The formation of Combination or oily skin is because skin oil and fat supersecretion causes, and fat secretion is too much, and the oils and fats support that pore can be stacked is large.Corse sweat pore normally due to hormone in vivo parasecretion, pressure is excessive and environmental pollution, cleaning do not carry out etc. that reason causes.In addition, with advancing age, skin follows the string gradually, and hair follicle lacks supporting construction around, is also easy to make pore to seem larger; Corse sweat pore is the greatest problem of puzzlement oiliness and mixing skin.In addition, the factors such as reinforcement at sunshine, metabolism quickening cause skin ingress of oil more vigorous, and pore seems can be more considerable.
Excessive oils and fats is deposited in pore, only can pore is more crowded larger.Oils and fats is wrapped in skin can become hoary hair's acne; Broken skin and go out to meet air oxidation blackening, will form blackhead, and more serious even can worsen into acne.The formation of acne, the former exactly oils and fats that should emit from pore, because the hyperkeratosis of pore mouth periphery is stopped up mixed product, so more long-pending the more when acne, pore also can more be supportted larger.
At present, in existing cosmetics, in order to control or regulate sebum secretion, be mainly to adopt some oil suction powder compositions, such as silicon dioxide, polymethyl methacrylate, nylon powder, boron nitride powder, Talcum, titanium dioxide, zinc oxide, silicon body etc.These compositions are from synthetic ingredient or mineralogical composition, except absorbing the ability of sebum, are difficult to have further effect.And current in order to modify the cosmetics of thick pore; mainly to utilize opaque granules such as filling silicide fast pore to be filled up; described opaque granule also possesses the optical effects such as soft focus, refraction conventionally; allow pore seem so unobvious, but can not fundamentally change the reality of corse sweat pore.Separately have and adopt chemicals composition to reach the way (such as adopting the compositions such as 5 alpha reductase inhibitors to control fat secretion amount) that reduces sebum and generate and dwindle pore effect, but it is subject to certain limitation in the expansion of day by day advocating the Cosmetic Market of natural health.
Therefore it is necessary, researching and developing the natural health cosmetics that aly can control fat secretion, can tighten again pore, careful skin.
Summary of the invention
One object of the present invention is to provide a kind of skin care compositions with control oil, pore refining effect, said composition comprises that by multiple natural animal-plant composition Herba Violae extract, Rhizoma Anemarrhenae extract, Radix Et Rhizoma Rhei extract etc. form, stable in properties, has the effect that nursing skin is particularly controlled oil, pore refining.
Another object of the present invention is to provide a kind of cosmetics that comprise described skin care compositions, can directly act on human body skin surface, nursing skin, reaches the effect of controlling oil, pore refining.
First, the invention provides a kind of skin care compositions with control oil, pore refining effect, said composition comprises Herba Violae extract, Rhizoma Anemarrhenae extract and Radix Et Rhizoma Rhei extract.
According to specific embodiment of the invention scheme, of the present invention have in the skin care compositions of controlling oil, pore refining effect, the compound proportion of Herba Violae extract, Rhizoma Anemarrhenae extract and Radix Et Rhizoma Rhei extract is to be converted to the weighing scale of traditional Chinese medicinal material raw materials Herba Violae, the Rhizoma Anemarrhenae, Radix Et Rhizoma Rhei, weight proportion is 4: 2～4: 1～5 (except indicating especially, ratio described in the present invention and content are part by weight and content).
According to specific embodiment of the invention scheme, in the skin care compositions with control oil, pore refining effect of the present invention, described Herba Violae extract is for take drying traditional Chinese medicinal materials Herba Violae as raw material is through 50%～80% (v/v) alcohol reflux and the extracting solution obtaining after removing chlorophyll.Herba Violae extract generally comprises the flavone compounds such as apigenin, apigenin and glycoside thereof, Quercetin, rutin, luteolin, is yellow transparent liquid.In the present invention, in every 1 gram of Herba Violae raw material, make 1g extracting solution, general flavone content 15～30mg/g in this extracting solution, to other performance indications things of Herba Violae extract without specific (special) requirements.
According to specific embodiment of the invention scheme, in the skin care compositions with control oil, pore refining effect of the present invention, described Rhizoma Anemarrhenae extract is for take the extracting solution that the drying traditional Chinese medicinal materials Rhizoma Anemarrhenae obtains through 60%～80% (v/v) ethanol extraction as raw material.Rhizoma Anemarrhenae extract contains Sarsasapogenin, Smilagenin, Tigogenin, Neotigogenin etc., for yellow is to amber color liquid.In the present invention, in every 1 gram of Rhizoma Anemarrhenae raw material, make 1g extracting solution, Rhizoma Anemarrhenae total saponins content 20～40mg/g in this extracting solution, to other performance indications things of Rhizoma Anemarrhenae extract without specific (special) requirements.
According to specific embodiment of the invention scheme, in the skin care compositions with control oil, pore refining effect of the present invention, described Radix Et Rhizoma Rhei extract is for take the extracting solution that drying traditional Chinese medicinal materials Radix Et Rhizoma Rhei obtains through 60%～80% (v/v) ethanol extraction as raw material.In Radix Et Rhizoma Rhei extract, mainly comprise Anthraquinones, polysaccharide, tannin class etc., wherein anthraquinone is the most important active component of Radix Et Rhizoma Rhei, anthraquinone is divided into sequestered and conjunction type, sequestered has chrysophanic acid, emodin, chrysaron, aloe-emodin, physcione, isoemodin, chrysophanol, laccaic acid etc., and conjunction type mainly comprises anthraquinone glycoside and dianthracene quinone ketoside.In the present invention, in every 1 gram of Radix Et Rhizoma Rhei raw material, make 1g extracting solution, Radix Et Rhizoma Rhei anthraquinone content 30～50mg/g in this extracting solution, to other performance indications things of Radix Et Rhizoma Rhei extract without specific (special) requirements.
According to specific embodiment of the invention scheme, of the present invention have in the skin care compositions of controlling oil, pore refining effect, Herba Violae extract, Rhizoma Anemarrhenae extract and Radix Et Rhizoma Rhei extract can extract and obtain voluntarily according to prior art, except meeting the above-mentioned active constituent content requirement of the present invention, (above-mentioned effective ingredient concentration is all in every gram of raw material, to make 1g or 1ml extracting solution for proportioning in producing is convenient to each extract, those skilled in the art can suitably dilute or concentrate according to practical situation) outside, correlated quality standard-required should be met.
According to specific embodiment of the invention scheme, of the present invention have control oil, in the skin care compositions of pore refining effect, described Herba Violae extract extracts and obtains in accordance with the following methods: the drying traditional Chinese medicinal materials of Herba Violae was pulverized to 80 mesh sieves, according to every gram of Herba Violae 10～20mL, extract the ratio of solvent, take 50～80% ethanol as extracting solvent, three times (preferably three quantity of solvent are identical for 70～90 ℃ of insulation reflux, extract, can be suitably after each extraction centrifugal or filter with collection extracting solution, the leaching process of other Chinese crude drug extracts is similar, repeat no more), each 60～120min, merge three times extracting solution, the concentrated ethanol of removing, then adjust pH value in 2～8 scopes, add adsorbent adsorbing separation chlorophyll, 0.45 μ m membrane filtration falls adsorbent afterwards, obtain Herba Violae extracting solution.According to the method, extracting the Herba Violae extracting solution obtaining is yellow transparent liquid, in every 1 gram of Herba Violae raw material, makes 1g extracting solution (can suitably concentrate or dilute to be adjusted to this concentration), wherein effective ingredient general flavone content 15～30mg/g.In this extracting method, utilize the chlorophyllous process of adsorbent adsorbing separation to carry out with reference to the routine techniques in affiliated field, such as adding the adsorbents such as active carbon, PSA, Graphon, aluminium oxide, Florey tripoli, conventionally, every 50ml extracting solution adds 0.1～0.8g adsorbent, agitation as appropriate adsorbing separation chlorophyll, mocromembrane filters out adsorbent afterwards.
According to specific embodiment of the invention scheme, of the present invention have in the skin care compositions of controlling oil, pore refining effect, described Rhizoma Anemarrhenae extract extracts and obtains in accordance with the following methods: the drying traditional Chinese medicinal materials of the Rhizoma Anemarrhenae was pulverized to 80 mesh sieves, according to the every gram of Rhizoma Anemarrhenae 4～10mL, extract the ratio of solvent, take 60～80% ethanol as extracting solvent, 70～90 ℃ are incubated reflux, extract, three times, each 30～60min, merge three times extracting solution, the concentrated ethanol of removing, with after 0.45 μ m membrane filtration, obtain Rhizoma Anemarrhenae extracting solution.It is yellow to amber color liquid according to the method, extracting the Rhizoma Anemarrhenae extracting solution obtaining, and makes 1g extracting solution, Rhizoma Anemarrhenae total saponins content 20～40mg/g in extracting solution in every 1 gram of Herba Violae raw material.
According to specific embodiment of the invention scheme, of the present invention have in the skin care compositions of controlling oil, pore refining effect, described Radix Et Rhizoma Rhei extract extracts and obtains in accordance with the following methods: the drying traditional Chinese medicinal materials of Radix Et Rhizoma Rhei was pulverized to 100 mesh sieves, according to every gram of Radix Et Rhizoma Rhei 10～25mL, extract the ratio of solvent, take 60%～80% ethanol as extracting solvent, at 40～90 ℃, lixiviate is three times, each 15～75min, merge three times extracting solution, the concentrated ethanol of removing, and with active carbon, filtrate decoloured and de-tasted, 0.45 μ m membrane filtration, obtains Radix Et Rhizoma Rhei extract.According to the method, extracting the Radix Et Rhizoma Rhei extract obtaining is yellow transparent liquid, makes 1g extracting solution, Radix Et Rhizoma Rhei anthraquinone content 30～50mg/g in extracting solution in every 1 gram of Radix Et Rhizoma Rhei raw material.In this extracting method, also can carry out suitable decolouring and de-taste processing Radix Et Rhizoma Rhei extract, in order to it, be applied to better cosmetics.Concrete decolouring processing mode can be carried out with reference to the routine techniques in affiliated field.
According to specific embodiment of the invention scheme, of the present invention have in the skin care compositions of controlling oil, pore refining effect, and general flavone content is more than or equal to 6mg/g; Rhizoma Anemarrhenae total saponins content is more than or equal to 6mg/g; Radix Et Rhizoma Rhei anthraquinone content is more than or equal to 9mg/g.This skin care compositions with control oil, pore refining effect mixes (can suitably concentrate as required or dilute) and obtains by extracting according to the method described above the Herba Violae extracting solution, Rhizoma Anemarrhenae extracting solution and the Radix Et Rhizoma Rhei extract that obtain.More specifically, can be to be obtained by mixing (can suitably concentrate as required or dilute) by take Herba Violae extracting solution, Rhizoma Anemarrhenae extracting solution and the Radix Et Rhizoma Rhei extract that traditional Chinese medicinal material raw materials Herba Violae, the Rhizoma Anemarrhenae, Radix Et Rhizoma Rhei weight proportion be 4: 2～4: 1～5; Or directly the Radix Et Rhizoma Rhei extract of the Rhizoma Anemarrhenae extracting solution of the Herba Violae extracting solution of general flavone content 15～30mg/g, Rhizoma Anemarrhenae total saponins content 20～40mg/g, Radix Et Rhizoma Rhei anthraquinone content 30～50mg/g is obtained by mixing according to 4: 2～4: 1～5 ratio.Conventionally, of the present invention have in the skin care compositions of controlling oil, pore refining effect, general flavone content 6～12mg/g; Rhizoma Anemarrhenae total saponins content 6～12mg/g; Radix Et Rhizoma Rhei anthraquinone content 9～15mg/g.
Skin care compositions of the present invention, it consists of the natural component that extraction obtains from plant, said composition has good control oil, pore refining effect, is particularly suppressing to have synergism aspect 5 alpha-reductases, antiinflammatory, oil-control secretion, pore refining.Bacteria inhibiting composition of the present invention can be applicable in skin type or clean class cosmetics, gives cosmetics control oil, pore refining effect.
Thereby the present invention also provides the described skin care compositions with control oil, pore refining effect to have the application in the cosmetics that suppress 5 alpha-reductases, antiinflammatory, oil-control secretion and/or pore refining effect in preparation.Particularly, described cosmetics can be skin-care cosmetics (such as cosmetic water etc.) or clean class cosmetics (such as facial milk cleanser etc.).Particularly, in general flavone content in the described skin care compositions with control oil, pore refining effect, be more than or equal to that 6mg/g, Rhizoma Anemarrhenae total saponins content are more than or equal to 6mg/g, Radix Et Rhizoma Rhei anthraquinone content is more than or equal to 9mg/g, this skin care compositions is that the amount that accounts for cosmetics gross weight 0.5%～8% is applied in these cosmetics.
On the other hand, the present invention also provides a kind of cosmetics, wherein contains the skin care compositions with control oil, pore refining effect of the present invention.Described cosmetics can be skin-care cosmetics (such as cosmetic water etc.) or clean class cosmetics (such as facial milk cleanser, cleansing cream, shampoo, bath shampoo etc.).Particularly, in general flavone content in the described skin care compositions with control oil, pore refining effect, be more than or equal to that 6mg/g, Rhizoma Anemarrhenae total saponins content are more than or equal to 6mg/g, Radix Et Rhizoma Rhei anthraquinone content is more than or equal to 9mg/g, the addition of this skin care compositions in cosmetics is 0.5%～8% of cosmetics gross weight, can have different content according to the concrete kind difference of cosmetics.
In the present invention, described in there is control oil, pore refining effect skin care compositions can be to add to mutually in described cosmetics as adding.According to specific embodiment of the invention scheme, cosmetics of the present invention are except comprising the described skin care compositions with control oil, pore refining effect, selecting of other components can be carried out according to the routine operation in this area, for example can comprise oil phase and water that some are conventional, or other interpolation phases of commonly using in field under further comprising.In some emulsified make-ups, generally include emulsifying agent, excipient (thickening) agent, also can add basic material that cosmetics contain conventionally and necessary additive, emollient (vegetable oil for example for example, white oil, animal oil and derivant thereof etc.), wetting agent (glycerol for example, propylene glycol, 1, 3-butanediol etc.), essence, deionized water, antioxidant, antiseptic etc., also can add some nutritional labelings, the application of these concrete compositions and consumption can be selected according to the concrete kind of described cosmetics, or add according to convention amount, this is easy to grasp for a person skilled in the art.
When concrete production, can be according to conventional production method, adding phase time, the skin care compositions with control oil, pore refining effect of the present invention is added in described cosmetics, concrete is that control oil of the present invention, pore refining compositions are added as adding mutually.Control oil of the present invention, pore refining compositions are added in the cosmetics such as cream frost, emulsion, cleansing milk, cleansing cream, shampoo, cosmetic water or firming lotion, bath shampoo, by controlling rational addition and suitable process conditions, can not damage the structure of product, to the stability of cosmetics, adverse influence can be do not brought, the quality problems such as variable color, layering can be do not caused.
On the other hand, the present invention also provides a kind of method of preparing described cosmetics, and the raw material of described cosmetics forms and comprises oil phase, water and the skin care compositions with control oil, pore refining effect of the present invention, and the method comprises:
First make oil phase and the water of cosmetic material carry out preliminary emulsifying, adjust the temperature of this emulsification system when lower than 50 ℃, add the compositions with control oil, pore refining effect of the present invention, system, through stirring, further requires complete operation according to formula after cooling.
Generally speaking, the invention provides a kind of skin care compositions with control oil, pore refining effect, it is applied to the production of cosmetics, can play synergism to suppressing 5 alpha-reductases, antiinflammatory, oil-control secretion, pore refining, can avoid the stimulation of androgen to sebaceous gland, regulate sebaceous gland cell division and propagation, reach the oily effect of control, the inflammation that reparation causes because of excess sebum obstruction pore, thus impaired hair follicle repaired, receive fine, soft fur hole.And Chinese herbal medicine extract is gentle to skin, zest is less, and adding of they can better improve the attractive in appearance of skin.In addition cosmetic product outward appearance, inherent quality that, the present invention produces can maintain a long-term stability.
The specific embodiment
By specific embodiment, describe below the beneficial effect of implementation process of the present invention and generation in detail, be intended to help reader to understand better essence of the present invention and feature, not as restriction that can practical range to this case.
The preparation of embodiment 1, Herba Violae extract, Rhizoma Anemarrhenae extract, Radix Et Rhizoma Rhei extract and the preparation of compositions
In the present embodiment, Herba Violae, the Rhizoma Anemarrhenae, Radix Et Rhizoma Rhei are purchased from pharmacy.Prepare respectively in accordance with the following methods Herba Violae extract, Rhizoma Anemarrhenae extract, Radix Et Rhizoma Rhei extract:
Described Herba Violae extract extracts and obtains in accordance with the following methods: the drying traditional Chinese medicinal materials of Herba Violae was pulverized to 80 mesh sieves, take Tokyo Violet Herb 100g, according to every gram of Herba Violae 20mL, extract the ratio of solvent, the ethanol of 60% concentration of take be to extract solvent, 80 ℃ are incubated reflux, extract, three times, each 90min, after each extraction, filter to get filtrate, merge three times filtrate, the concentrated ethanol of removing, then adjusting pH value is 3 o'clock, every 50ml extracting solution adds 0.5g adsorbent, the separated chlorophyll of stirring and adsorbing, after 30min, mocromembrane filters, concentrated, obtain 100g Herba Violae extracting solution, according to the method, extracting the Herba Violae extracting solution obtaining is yellow transparent liquid, and wherein general flavone content is 27.6mg/g.
Described Rhizoma Anemarrhenae extract extracts and obtains in accordance with the following methods: the drying traditional Chinese medicinal materials of the Rhizoma Anemarrhenae was pulverized to 80 mesh sieves, take Common Anemarrhena Rhizome 100g, according to every gram of Rhizoma Anemarrhenae 8mL, extract the ratio of solvent, with concentration 70% alcoholic solution, extract solvent, 80 ℃ of insulation reflux, extract, 40min, centrifugal afterwards, filter, collect filtrate, repeat to extract three times, merging filtrate, the concentrated ethanol of removing, with 0.45 μ m membrane filtration, be adjusted to 100g, obtain Rhizoma Anemarrhenae extracting solution, according to the method, extracting the Rhizoma Anemarrhenae extracting solution obtaining is yellow extremely amber transparency liquid, Rhizoma Anemarrhenae total saponins content 32.7mg/g.
Described Radix Et Rhizoma Rhei extract extracts and obtains in accordance with the following methods: the drying traditional Chinese medicinal materials of Radix Et Rhizoma Rhei was pulverized to 100 mesh sieves, take 200g Rhubarb, and extracted the ratio of solvent according to every gram of Radix Et Rhizoma Rhei 20mL, the ethanol of 70% concentration of take be to extract solvent, and extracts 60min at 80 ℃, afterwards centrifugal, filter, collect filtrate, repeat to extract merging filtrate, the concentrated ethanol of removing three times, and with active carbon, filtrate decoloured and de-tasted, 0.45 μ m membrane filtration, concentrated, obtain 200g Radix Et Rhizoma Rhei extract.According to the method, extracting the Radix Et Rhizoma Rhei extract obtaining is yellow transparent liquid, records Radix Et Rhizoma Rhei anthraquinone content 39.3mg/g.
The skin care compositions with control oil, pore refining effect of the present embodiment obtains in accordance with the following methods: by above-mentioned, take Herba Violae extracting solution, Rhizoma Anemarrhenae extracting solution and Radix Et Rhizoma Rhei extract that Herba Violae, the Rhizoma Anemarrhenae, Radix Et Rhizoma Rhei obtain as raw material extracts respectively according to the part by weight mix homogeneously of 4:3:3, gained fraction is the skin care compositions with control oil, pore refining effect of the present invention.For example, the above-mentioned Herba Violae extracting solution 40g making, Rhizoma Anemarrhenae extracting solution 30g, Radix Et Rhizoma Rhei extract 30g can be mixed to the skin care compositions (hereinafter to be referred as embodiment 1 skin care compositions) with control oil, pore refining that obtains 100g the present embodiment 1 after composite.
Embodiment 2, inhibition 5 alpha-reductases experiments
5 alpha-reductases change testosterone catalysis into dihydrotestosterone in the presence of NADPH, if there are 5 alpha reductase inhibitors, just can suppress to a certain extent this course of reaction.Because NADPH has characteristic absorption at 340nm wavelength place, the NADP+ that participates in generating after reaction disappears in 340nm wavelength place characteristic absorption.With ultraviolet spectrophotometer, measure, can reflect that certain material is to the whether inhibited and inhibiting size of 5 alpha-reductases.Through repetition test, having established cumulative volume is the 5 alpha-reductase catalystic converter systems of 100 μ L.Each composition reaction volume is in Table 1.
Each reagent dosage of table 1 reaction system (μ L)
The mensuration of blank: add testosterone T, 5 alpha-reductases, phosphate buffer (pH=7.4), NADPH in reaction tube, after mixing, measure absorbance, after 37 ℃ of constant-temperature incubation 60min, measure absorbance, the blank decline background values of deduction NADPH, measures blank drop-out value Δ A
0=0.066.
The mensuration of inhibitor: add testosterone T, 5 alpha-reductases, inhibitor, phosphate buffer (pH=7.4), NADPH in reaction tube, after mixing, measure absorbance, after 37 ℃ of constant-temperature incubation 60min, measure absorbance, the blank decline background values of deduction NADPH, measures inhibitor drop-out value (Δ An).With the positive medicine of finasteride, judge that whether the activity of enzyme is suppressed, and the size of primary Calculation suppression ratio.Computing formula is I (%)=(Δ A
0-Δ An)/Δ A
0* 100%.
Measurement result is in Table 2.
The suppression ratio comparison of table 2 Finasteride and plant extract
As can be seen from Table 2, Herba Violae, the Rhizoma Anemarrhenae, the single plant extract of Radix Et Rhizoma Rhei all have inhibitory action in various degree to 5 alpha-reductases, but all lower than positive control Finasteride, the suppression ratio of the composite compositions forming of three, close to positive control Finasteride, illustrates that Herba Violae, the Rhizoma Anemarrhenae, Radix Et Rhizoma Rhei have synergism in 5 alpha-reductase inhibitory action.
Embodiment 3, antiinflammatory experiment
Get 50 of mices, male and female half and half, be divided at random 5 groups, every group 10, be blank (distilled water) group. ibuprofen matched group (ibuprofen concentration is 0.1mg/g), Herba Violae extracting solution, Rhizoma Anemarrhenae extracting solution, Radix Et Rhizoma Rhei extract, the skin care compositions of getting a certain amount of embodiment 1 preparation are diluted to 10mg/g, test group, the continuous 7d of gastric infusion.After last administration 30min, in mouse right ear, only evenly smear dimethylbenzene 50 μ L/, left ear is not coated with in contrast, after proinflammatory effect 30min, puts to death mice, cuts ears auricle, with the card punch of diameter 8mm, at ears same position, lays auricle, and claims its quality.Calculate swelling and inhibitory rate of intumesce.
The left auricle quality of swelling=auris dextra tablet quality one; Inhibitory rate of intumesce=(the average swelling of the average swelling one administration group of blank group)/average swelling of blank group] * 100%.
Experimental result is in Table 3.
Table 3 plant extract xylol causes the impact of mice swelling
With matched group comparison, Herba Violae extract, Rhizoma Anemarrhenae extract, Radix Et Rhizoma Rhei extract, skin care compositions and ibuprofen xylol induced mice ear swelling all have significant inhibitory action.Wherein embodiment 1 skin care compositions antiinflammatory action is better than single plant extract Herba Violae extract, Rhizoma Anemarrhenae extract, Radix Et Rhizoma Rhei extract, illustrates that this three Plant Extracts proportionally brought into play synergism after composite.
Embodiment 4, control oily effect and skin pore and improve average evaluation experiment
In the present embodiment, utilize respectively the composite skin care compositions obtaining of Herba Violae extracting solution, Rhizoma Anemarrhenae extracting solution, Radix Et Rhizoma Rhei extract and three in embodiment 1 as active matter, add to and in cosmetic base, prepare facial treatment milk, and take each facial treatment milk as test sample, investigate it and for control oil and skin pore, improve the effect of situation.Each formula and production technology of testing sample is as follows:
Production technology: the preparation of substrate (oil phase+water) traditionally, specifically the raw material in oil phase is added in oil phase reactor successively, raw material in water adds in aqueous phase reactions still, open and stir, be heated to 85～90 ℃, emulsifying, temperature is down to 50 ℃ and is added below interpolation phase raw material.The prepared active matter of respectively testing in sample is with reference to table 4.
Table 4 is respectively tested active matter in sample
| Test sample number into spectrum | Active matter |
| Sample 1 | Embodiment 1 skin care compositions |
| Sample 2 | Herba Violae extracting solution in embodiment 1 |
| Sample 3 | Rhizoma Anemarrhenae extracting solution in embodiment 1 |
| Sample 4 | Radix Et Rhizoma Rhei extract in embodiment 1 |
| Sample 5 (control sample) | Nothing |
Experimental technique:
Volunteer requires: 22～40 years old age, male and women each half, oiliness and Combination skin, without any dermatosis and skin allergy history, participate in voluntarily test, before test, signature Informed Consent Form, tests and can not use any cosmetics in first 2 days, must not use test sample any cosmetics in addition in process of the test.Experimenter, with after warm water cleaning face, is evenly applied to face by cosmetic formulations, and each once, is tried out 8 weeks sooner or later.
1, control oil experiment
Experimental principle: oils and fats is tested based on photometer principle.Select the special delustring adhesive tape that a kind of 0.1mm is thick, can absorb rapidly the oils and fats on human body skin.Due to the effect of oils and fats, delustring adhesive tape becomes translucent, and the oils and fats of absorption is more, and light transmission capacity will be larger, uses photometric determination light transmission capacity, according to the variation of light transmission capacity generation before and after delustring adhesive tape, can measure the content of skin oil and fat.
Test instrunment: the cuotometer MPA580 oils and fats test probe Sebumeter that German Courage+Khazaka company (German CK company) manufactures
Before using, follow up a case by regular visits to respectively and test once after 2,4,6,8 weeks with use.Take the form that enters at random group to carry out, select the tested region of experimenter's face forehead.1 group of experimenter uses sample 1; 2 groups are used sample 2; 3 groups are used 3,4 groups, sample to use sample 4; Matched group is used sample 5.Technical staff uses skin oil and fat test probe test test position 3 times, averages, and gathers for the first time blank value.
Adopt sooner or later smear every day 2 times, respectively smear experimenter sooner or later and using sample 2 weeks continuously, 4 weeks, 6 weeks, 8 weeks, by technical staff, use skin oil and fat probe measurement 3 times, average, test position forehead.
The numerical value that statistics records, adopts averaging method, analyzing skin fat secretion Changing Pattern and persistency.
Interpretation of result: fat content variation was reflected in test period, pilot region fat content change with time.Concrete outcome is referring to table 5.
Table 5 is used the front and rear different time forehead skin oil and fat content of use
| ? | Before use | 2 weeks | 4 weeks | 6 weeks | 8 weeks |
| 1 group | 63.17±20.06 | 47.50±14.73 | 48.00±9.35 | 48.17±13.19 | 48.67±7.36 |
| 2 groups | 59.83±19.25 | 53.33±14.73 | 55.00±16.27 | 54.83±15.28 | 54.17±17.11 |
| 3 groups | 62.67±19.46 | 56.17±13.19 | 56.84±13.19 | 56.00±15.66 | 56.17±14.57 |
| 4 groups | 65.33±15.49 | 58.83±8.14 | 56.84±8.73 | 59.00±12.81 | 59.17±14.36 |
| 5 groups | 65.67±11.06 | 65.00±15.95 | 66.67±12.13 | 65.83±11.47 | 66.17±13.12 |
At 5 groups of skin oil and fats of 8 weeks internal reference groups, change not obvious, 1～4 group of skin oil and fat presents the trend of minimizing, illustrate that the sample that adds active matter has control oil effect to a certain degree, among 4 groups, 1 group is suppressed skin oil and fat secretion successful, with respect to other groups, possesses the effect of significant control fat secretion, can show that the compound of Herba Violae extract, Rhizoma Anemarrhenae extract, Radix Et Rhizoma Rhei extract has synergism aspect control fat secretion.
2, skin pore improves evaluation test
Select facial same position as test position.Adopt digimiC800 type skin image analyser test skin pore aperture, by same position pore shooting (magnify 20), analyze and draw pore pore size, for assessment of the careful pore effect of cosmetic formulations.Experimental result is in Table 6.
The tested rear pore of table 6 aperture
| Detect index | Before use | 2 weeks | 4 weeks | 6 weeks | 8 weeks |
| 1 group | 184.3±20.13 | 179.3±21.36 | 173.2±19.27 | 169.5±16.49 | 163.4±17.28 |
| 2 groups | 193.2±25.4 | 188.7±22.82 | 182.3±21.95 | 178.7±26.24 | 177.3±20.13 |
| 3 groups | 188.7±19.38 | 185.7±26.24 | 183.9±10.27 | 180.6±15.66 | 178.2±14.56 |
| 4 groups | 194.6±24.23 | 190.4±24.76 | 187.5±17.93 | 184.7±19.37 | 182.6±24.32 |
| 5 groups | 189.7±20.3 | 190.3±20.13 | 189.8±20.13 | 192.5±18.37 | 190.7±25.25 |
1 group is used sample after 1 eight weeks, and skin pore aperture dwindles obviously, before the elasticity of skin and degree of compacting are also obviously better than trying out.Use continuously after 8 weeks, facial pore aperture ratio dwindles 19.1～23.3 μ m before using, and skin becomes fine and smooth and compacts.2 groups are used sample before the use of skin pore aperture ratio, to reduce by 14.3～17.4 μ m after 2 eight weeks.3 groups are used sample before the use of skin pore aperture ratio, to reduce by 9.1～12.4 μ m after 3 eight weeks.4 groups are used sample before the use of skin pore aperture ratio, to reduce by 10.5～14.7 μ m after 3 eight weeks.5 groups are used 5 eight weeks interior skin pore varying aperture of sample not obvious.As can be seen here, the compound of Herba Violae extract, Rhizoma Anemarrhenae extract, Radix Et Rhizoma Rhei extract has synergism at pore refining.Control oil of the present invention, pore refining compositions are significantly improved the effect of pore to facial skin.
Embodiment 5, control oily facial milk cleanser
The present embodiment utilizes Herba Violae extracting solution, Rhizoma Anemarrhenae extracting solution, the Radix Et Rhizoma Rhei extract that embodiment 1 extracts to produce the oily facial milk cleanser of a kind of control.Its formula and technique are as follows:
Formula:
Control oil, pore refining compositions (the Herba Violae extracting solution that embodiment 1 extracts, Rhizoma Anemarrhenae extracting solution, Radix Et Rhizoma Rhei extract form according to the weight ratio of 4:4:2 is composite) 4%
Preparation method:
Mix B phase, be heated to 70～75 ℃, after fusing, add C phase; By A phase Hybrid Heating to 70 ℃, add B to carry out mutually saponification, after 30min, add D mutually and stir; Be cooled to 50 ℃ to add E phase, stir, continue to cool to 30 ℃ while spending, discharging after the assay was approved.
The facial milk cleanser of the present embodiment, without unacceptable abnormal flavour.Cold-resistant (5 ± 1 ℃) heat-resisting (40 ± 1 ℃) through 24h are placed test, and system is normal, without crystallization, without muddiness, variable color, lamination.The every sense index of product, physical and chemical index, sanitary index all meet corresponding national standard.
The facial milk cleanser of the present embodiment, through 10 22～40 years old volunteers, after 2 weeks on probation, all reflection has the oily effect of obvious control.
Embodiment 6, the control oil cosmetic water that compacts
The present embodiment utilizes Herba Violae extracting solution, Rhizoma Anemarrhenae extracting solution, Radix Et Rhizoma Rhei extract that embodiment 1 extracts to produce a kind of control oil cosmetic water that compacts.Its formula and technique are as follows:
Formula:
Skin care compositions (the Herba Violae extracting solution that embodiment 1 extracts, Rhizoma Anemarrhenae extracting solution, Radix Et Rhizoma Rhei extract form according to the weight ratio of 4:2.5:3.5 is composite) 0.5
Antiseptic is appropriate
Essence 0.01～0.15
Deionized water is added into 100%
Preparation method:
1. hyaluronate sodium is configured to 1% aqueous solution, standby.
2. all materials except skin care compositions, aqueous solution of sodium hyaluronate, antiseptic, essence are added in reactor, open stirring (rotating speed is 30rpm), open heating simultaneously, temperature is controlled at 90 ℃～98 ℃, sterilizing 5min.
3., when material stirring is cooled to 45 ℃, add compositions, aqueous solution of sodium hyaluronate, antiseptic, essence, and stir.
4. after the assay was approved, temperature is down to 38 ℃ and is got final product below fill.
The interpolation of the present embodiment the cosmetic water of control oil, pore refining compositions faint yellow, pure transparent, without unacceptable abnormal flavour.Cold-resistant (5 ± 1 ℃) heat-resisting (40 ± 1 ℃) through 24h are placed test, without crystallization, without wild effects such as variable colors.The every sense index of product, physical and chemical index, sanitary index all meet corresponding national standard.
The cosmetic water of the present embodiment, through 10 22～40 years old female volunteers after 4 weeks on probation, all thinks and has the effect of obvious control oil and pore refining.
Claims (10)
1. a skin care compositions with control oil, pore refining effect, said composition comprises Herba Violae extract, Rhizoma Anemarrhenae extract and Radix Et Rhizoma Rhei extract.
2. the skin care compositions with control oil, pore refining effect according to claim 1, wherein, the compound proportion of Herba Violae extract, Rhizoma Anemarrhenae extract and Radix Et Rhizoma Rhei extract is to be converted to the weighing scale of traditional Chinese medicinal material raw materials Herba Violae, the Rhizoma Anemarrhenae, Radix Et Rhizoma Rhei, and weight proportion is 4: 2～4: 1～5.
3. the skin care compositions with control oil, pore refining effect according to claim 1, wherein:
Described Herba Violae extract is for take drying traditional Chinese medicinal materials Herba Violae as raw material is through 50%～80% alcohol reflux and the extracting solution obtaining after removing chlorophyll, in every 1 gram of Herba Violae raw material, make 1g extracting solution, general flavone content 15～30mg/g in this extracting solution;
Described Rhizoma Anemarrhenae extract, for take the extracting solution that the drying traditional Chinese medicinal materials Rhizoma Anemarrhenae obtains through 60%～80% ethanol extraction as raw material, is made 1g extracting solution in every 1 gram of Rhizoma Anemarrhenae raw material, Rhizoma Anemarrhenae total saponins content 20～40mg/g in this extracting solution;
Described Radix Et Rhizoma Rhei extract, for take the extracting solution that drying traditional Chinese medicinal materials Radix Et Rhizoma Rhei obtains through 60%～80% ethanol extraction as raw material, is made 1g extracting solution in every 1 gram of Radix Et Rhizoma Rhei raw material, Radix Et Rhizoma Rhei anthraquinone content 30～50mg/g in this extracting solution.
4. the skin care compositions with control oil, pore refining effect according to claim 1, wherein:
Described Herba Violae extract extracts and obtains in accordance with the following methods: the drying traditional Chinese medicinal materials of Herba Violae was pulverized to 80 mesh sieves, according to every gram of Herba Violae 10～20mL, extract the ratio of solvent, take 50～80% ethanol as extracting solvent, 70～90 ℃ are incubated reflux, extract, three times, each 60～120min, merge three times extracting solution, the concentrated ethanol of removing, then adjust pH value in 2～8 scopes, add adsorbent adsorbing separation chlorophyll, 0.45 μ m membrane filtration falls adsorbent afterwards, obtains Herba Violae extracting solution;
Described Rhizoma Anemarrhenae extract extracts and obtains in accordance with the following methods: the drying traditional Chinese medicinal materials of the Rhizoma Anemarrhenae was pulverized to 80 mesh sieves, according to the every gram of Rhizoma Anemarrhenae 4～10mL, extract the ratio of solvent, take 60～80% ethanol as extracting solvent, 70～90 ℃ are incubated reflux, extract, three times, each 30～60min, merges three times extracting solution, the concentrated ethanol of removing, with after 0.45 μ m membrane filtration, obtain Rhizoma Anemarrhenae extracting solution;
Described Radix Et Rhizoma Rhei extract extracts and obtains in accordance with the following methods: the drying traditional Chinese medicinal materials of Radix Et Rhizoma Rhei was pulverized to 100 mesh sieves, according to every gram of Radix Et Rhizoma Rhei 10～25mL, extract the ratio of solvent, take 60%～80% ethanol as extracting solvent, at 40～90 ℃, lixiviate is three times, and each 15～75min merges three times extracting solution, the concentrated ethanol of removing, and with active carbon, filtrate decoloured and de-tasted, 0.45 μ m membrane filtration, obtains Radix Et Rhizoma Rhei extract.
5. according to the skin care compositions with control oil, pore refining effect described in claim 1～4 any one, in said composition, general flavone content is more than or equal to 6mg/g; Rhizoma Anemarrhenae total saponins content is more than or equal to 6mg/g; Radix Et Rhizoma Rhei anthraquinone content is more than or equal to 9mg/g.
6. the skin care compositions with control oil, pore refining effect described in claim 1～5 any one has the application in the cosmetics that suppress 5 alpha-reductases, antiinflammatory, oil-control secretion and/or pore refining effect in preparation.
7. application according to claim 6, wherein, in general flavone content in the described skin care compositions with control oil, pore refining effect, be more than or equal to that 6mg/g, Rhizoma Anemarrhenae total saponins content are more than or equal to 6mg/g, Radix Et Rhizoma Rhei anthraquinone content is more than or equal to 9mg/g, this skin care compositions is that the amount that accounts for cosmetics gross weight 0.5%～8% is applied in cosmetics.
8. cosmetics, wherein contain the skin care compositions with control oil, pore refining effect described in claim 1～5 any one.
9. cosmetics according to claim 8, wherein, in general flavone content in the described skin care compositions with control oil, pore refining effect, be more than or equal to that 6mg/g, Rhizoma Anemarrhenae total saponins content are more than or equal to 6mg/g, Radix Et Rhizoma Rhei anthraquinone content is more than or equal to 9mg/g, the addition of this skin care compositions in cosmetics is 0.5%～8% of cosmetics gross weight.
10. cosmetics according to claim 8, it is skin type or washing class cosmetics.
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| CN104069034B (en) | 2017-04-12 |
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