CN105288041A - Traditional Chinese medicine preparation for preventing and treating nephrotic syndrome and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for preventing and treating nephrotic syndrome and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for preventing and treating a nephrotic syndrome. The traditional Chinese medicine preparation is prepared from, by weight, 8-13 parts of codonopsis pilosula, 10-14 parts of arundina chinensis, 6-9 parts of raspberries, 9-12 parts of ixeris japonica, 7-14 parts of sedum aizoon, 8-12 parts of semen plantaginis, 9-13 parts of edelweiss, 7-15 parts of lotus petiole petiolus, 6-13 parts of desmodium triquetrum, 4-10 parts of morinda officinalis, 5-9 parts of garden erphorbia herb, 3-9 parts of periostracum cicada, 7-11 parts of herpetospermum pedunculosum seeds, 9-14 parts of petasites japonicus, 8-15 parts of stir-fried Chinese yam and 6-12 parts of roots of uraria crinit. The traditional Chinese medicine preparation has the advantages that the medicine raw materials bring out the best in each other, the nephrotic syndrome can be significantly relieved, and the effects of invigorating spleen and supplementing qi, tonifying kidney and strengthening the body resistance, promoting blood circulation to remove blood stasis, and clearing heat and promoting urination are achieved.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine preparation and method for making of preventing and treating nephrotic syndrome.
Background technology
Nephrotic syndrome (nephroticsyndrome, NS) shows as one group of clinical syndrome of High-grade Proteinuria, hypoproteinemia, treating serious edema caused, hyperlipemia.High-grade Proteinuria refers to when particularly electrostatic barrier is impaired for the molecular barriers of glomerular filtration membrane and electrostatic barrier, glomerular filtration membrane increases the permeability of plasma protein, cause protein content in urine to increase, when exceeding Distal convoluted tubule and returning absorbtivity, form High-grade Proteinuria.Hypoalbuminemia refers to that a large amount of albumin is lost from urine, promote that albumin synthesizes at the compensatory of liver, hepatoalbumin synthesis increase is not enough to overcome loss, in addition, because of gastrointestinal tract mucous edema cause diet to go down, albumen Deficiency of Intake, malabsorption or to lose also be the reason of hypoalbuminemia.Treating serious edema causedly refer to that hypoalbuminemia makes plasma colloid osmotic pressure decline, moisture enters interstice from Endovascular.Hyperlipemia refers to that in hypercholesterolemia or hypertriglyceridemia, serum, LDL, VLDL and lipoprotein concentration increase, and normal and hypoalbuminemia is also deposited, its mechanism increases with liver synthetic fat albumen and lipoprotein decompose weaken relevant.Primary disease can be caused by Different types of etiopathogenises, and be divided into constitutional, Secondary cases and heritability three major types, primary nephrotic syndrome belongs to primary glomerulopathy, has multiple histological type to form.Numerous disease can cause the damage of glomerular capillary filter membrane, causes nephrotic syndrome.
Chinese medicine thinks that nephrotic syndrome belongs to " edema ", " turbid urine ", " asthenia ", the category such as " lumbago ".The early stage edema of pathological changes of nephrotic syndrome more very, real to mark, step back, and urine protein continues not disappear, and pathological changes focuses on asthenia of both the spleen and kidney by later stage pathogenic water.The etiology and pathogenesis of nephrotic syndrome is many causes vital essence exopathogen, dysfunction of the kidney in storing essence, the dirty functional disorder of lung spleen kidney three because exopathogen invasion, spleen feritin are empty etc., thus wind-cold damp pathogen heap soil or fertilizer over and around the roots, cereal nutrient scarcity, the skin that overflows, water retention, water liquid dysbolismus and causing.Primary disease for mark with congestion, damp and hot, cold-damp, ailment said due to cold or exposure, take deficiency of spleen and stomach as this, belongs to the card of vital QI being weakened and pathogen being violent.Treatment should based on warming and recuperating the spleen and kidney.
Application publication number CN104888030A(application number 201510389171.2) Chinese invention patent document disclose a kind of medicine being used for the treatment of nephrotic syndrome, be prepared from by the raw medicinal material of following parts by weight: Semen Phaseoli Vulgaris 25 parts of, Glyptosternon maculatus (Rogan).s 3 parts, Herba Solani Lyrati 25 parts, Radix Ardisiae Crispae 12 parts, thunder-crash bomb 3 parts, Radix Pittospori 15 parts, Herba silenes fortunei 15 parts, Semen Setariae italicae 12 parts.Application publication number CN103877327A(application number 201410119524.2) Chinese invention patent document disclose a kind of pharmaceutical composition for the treatment of nephrotic syndrome and its production and use, the preparation be prepared from by the crude drug of following weight proportion: Herba Equiseti Hiemalis 154-462 part, Folium Pyrrosiae 154-462 part, Herba Leonuri 192.5-577.5 part, Herba Houttuyniae 257-771 part, Herba Hedyotidis Diffusae 257-771 part, Rhizoma Osmundae 192.5-577.5 part, Rhizoma Dioscoreae Septemlobae 154-462 part, Semen Oroxyli 154-462 part.Application publication number CN104258204A(application number 201410567939.6) Chinese invention patent document disclose a kind of Chinese medicine composition and the application in preparation treatment nephrotic syndrome medicine thereof, be prepared from by the raw medicinal material of following weight proportion: Radix seu Caulis Schisandrae Sinensis 5-10 part, Herba Gerberae Piloselloidis 6-15 part, Rhizoma Corydalis 3-15 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 15-25 part, Fructus Hordei Germinatus 9-15 part, Caulis Spatholobi 10-15 part, Fructus Rubi obcordati 25-50 part or fresh Fructus Rubi obcordati 50-100 part, Semen Coicis root 30-60 part or fresh Semen Coicis root 60-120 part, Radix Glycyrrhizae 3-10 part.
The current western medical treatment nephrotic syndrome generally takes symptomatic treatment and hormone, cytotoxic drug, achieve certain curative effect, not only easily recur, and due to the impact of hormone, cytotoxic drug, the side effect of generation increases the weight of patient suffering and financial burden; And the Chinese medicine of existing treatment nephropathy, curative effect is not remarkable.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese medicine preparation prepared simple, taking convenience, prevent and treat nephrotic syndrome safely and effectively.Chinese medicine preparation of the present invention is evident in efficacy and without any side effects, easy to utilize.
Technical scheme of the present invention is:
Prevent and treat a Chinese medicine preparation for nephrotic syndrome, be prepared from by following bulk drugs, be weight portion: Radix Codonopsis 8-13; Herba Murdanniae Divergentis 10-14; Fructus Rubi 6-9; Herba ixeritis debilis 9-12; Herba Sedi Aizoon 7-14; Semen Plantaginis 8-12; Leontopodium leontopodioides (Willd.) Beauv. 9-13; Petiolus nelumbinis 7-15; Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 6-13; Radix Morindae Officinalis 4-10; Herba Euphoubiae Hirtae 5-9; Periostracum Cicadae 3-9; Herpetospermum caudigerum Wall. 7-11; Petasites japonicus 9-14; Rhizoma Dioscoreae (stir-fry) 8-15; Radix Urariae crinitae 6-12.
In preferred scheme, Radix Codonopsis 9.5-11.5; Herba Murdanniae Divergentis 11-13; Fructus Rubi 7-8; Herba ixeritis debilis 10-11; Herba Sedi Aizoon 9-12; Semen Plantaginis 9.5-10.5; Leontopodium leontopodioides (Willd.) Beauv. 10-12; Petiolus nelumbinis 9-13; Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 8-11; Radix Morindae Officinalis 6-8; Herba Euphoubiae Hirtae 6-8; Periostracum Cicadae 4.5-7.5; Herpetospermum caudigerum Wall. 8-10; Petasites japonicus 10-13; Rhizoma Dioscoreae (stir-fry) 10-13; Radix Urariae crinitae 8-10.
Be more preferably, Radix Codonopsis 10.5; Herba Murdanniae Divergentis 12; Fructus Rubi 7.5; Herba ixeritis debilis 10.5; Herba Sedi Aizoon 10.5; Semen Plantaginis 10; Leontopodium leontopodioides (Willd.) Beauv. 11; Petiolus nelumbinis 11; Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 9.5; Radix Morindae Officinalis 7; Herba Euphoubiae Hirtae 7; Periostracum Cicadae 6; Herpetospermum caudigerum Wall. 9; Petasites japonicus 11.5; Rhizoma Dioscoreae (stir-fry) 11.5; Radix Urariae crinitae 9.
Prevent and treat a preparation method for the medicine pill of nephrotic syndrome, step is as follows:
(1) Radix Morindae Officinalis, Semen Plantaginis and Herpetospermum caudigerum Wall. mixing, the Sucus Zingberis adding 0.2-0.4 times amount is mixed thoroughly (Sucus Zingberis preferably adding 0.3 times amount is mixed thoroughly), and slow fire adds to be propagandized hotly to medical material to be buff, to take out, for subsequent use; Radix Codonopsis and Radix Urariae crinitae mixing, add content be the yellow wine of 18%-26% mix thoroughly (preferably add content be 22% yellow wine mix thoroughly), intense fire adds to be propagandized hotly to medical material surface in yellowish-brown, takes out, for subsequent use;
(2) Periostracum Cicadae is cleaned, and drains, and is placed in 4-5 and becomes the Oleum sesami of heat to explode to golden yellow, take out, suck excess surface oil content, grind as smalls, for subsequent use; Get fresh Fructus Rubi, add the Mel (preferably adding the Mel of 0.15 times amount) of 0.1-0.2 times amount, mix thoroughly, smash into mud to pieces, dry, porphyrize, for subsequent use; Rhizoma Dioscoreae shave, is placed in hot sand, and slow fire heats, and fry to medical material surface in light yellow, sieve shakeout, grinds to form fine powder, for subsequent use;
(3) crude drug after step (1) being processed and Herba Murdanniae Divergentis, Herba ixeritis debilis, Leontopodium leontopodioides (Willd.) Beauv., Petasites japonicus and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) are together placed in medicine pot, add clear water and do not have powder, slow fire boiling twice, first time decocts 28-42 minute (preferably first time decocts 35 minutes), and second time decocts 16-30 minute (preferably second time decocts 23 minutes), filters, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.22-1.25, spraying dry, get dry extract powder, for subsequent use;
(4) Herba Sedi Aizoon, Petiolus nelumbinis fully be dry, pulverize into fine powder with Herba Euphoubiae Hirtae, mix with step (2) gained raw material medicated powder and step (3) gained dried cream powder, cross 115-145 mesh sieve (preferred mistake 130 mesh sieve), with water pill, make the pill of Semen Firmianae size, to obtain final product.
Above-mentioned a kind of preparation method of preventing and treating the medicine pill of nephrotic syndrome, preferred scheme is, temperature dry in step (2) is 42-56 DEG C (preferred dry temperature is 46-52 DEG C, and the temperature of the drying be more preferably is 50 DEG C).
Above-mentioned a kind of preparation method of preventing and treating the medicine pill of nephrotic syndrome, preferred scheme is, the time dry in step (2) is 2.5-4.5 hour (the preferred dry time is 3-4 hour, and the time of the drying be more preferably is 3.5 hours).
The preparation method of described decoction is:
(1) Rhizoma Dioscoreae shave, is placed in hot sand, and slow fire heats, and fry to medical material surface in light yellow, sieve shakeout, grinds to form fine powder, for subsequent use; Herpetospermum caudigerum Wall. and Semen Plantaginis mixing, the Zhenjiang rice vinegar being placed in 1.6-2.2 times amount soaks 35-55 minute (the Zhenjiang rice vinegar being preferably placed in 1.9 times amount soaks 45 minutes), take out, being placed on smokeless intense fire bakes to medical material surface slightly focal spot, takes out, smashs into fine powder to pieces while hot, mix with Rhizoma Dioscoreae powder, cross 85-115 mesh sieve (preferred mistake 100 mesh sieve), obtain mixed powder, for subsequent use;
(2) Radix Codonopsis and Radix Urariae crinitae mixing, add content be the yellow wine of 18%-26% mix thoroughly (preferably add content be 22% yellow wine mix thoroughly), intense fire adds to be propagandized hotly to medical material surface in yellowish-brown, takes out, for subsequent use;
(3) Petiolus nelumbinis, Fructus Rubi, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Herba Sedi Aizoon, Herba Euphoubiae Hirtae and Petasites japonicus mixing, be placed in marmite, add the cold water (preferably adding the cold water of 5.5 times amount) of 4.5-6.5 times amount, soak under room temperature 1.6-3.0 hour (soaking 2.3 hours under being preferable over room temperature), then add step (1) gained mixed powder, big fire heated and boiled 6-12 minute (preferred big fire heated and boiled 9 minutes), turn little fire and decoct slowly 25-38 minute (preferably turn little fire and decoct 32 minutes slowly), filter, filtrate is for subsequent use;
(4) crude drug after step (2) being processed mixes with Herba Murdanniae Divergentis, Herba ixeritis debilis, Leontopodium leontopodioides (Willd.) Beauv., Petiolus nelumbinis and Periostracum Cicadae, add water and do not have powder, slow fire boiling twice, each respectively decoction 18-30 minute (preferably each each decoction 24 minutes), merges twice decocting liquid, filtration, filtrate and step (3) gained filtrate merge, be evaporated to the half of original volume, sterilizing encapsulates, and to obtain final product.
The preparation method of described tablet is:
(1) Rhizoma Dioscoreae shave, is placed in hot sand, and slow fire heats, and fry to medical material surface in light yellow, sieve shakeout, grinds to form fine powder, for subsequent use; Periostracum Cicadae is cleaned, and drains, and is placed in 4-5 and becomes the Oleum sesami of heat to explode to golden yellow, take out, suck excess surface oil content, grind as smalls, for subsequent use; Fructus Rubi adds the Chinese liquor of 0.3-0.5 times amount and mixes thoroughly (Chinese liquor that preferred Fructus Rubi adds 0.4 times amount is mixed thoroughly), is placed in intense fire on tile and dries, grind to the powder, for subsequent use;
(2) by Radix Codonopsis, Semen Plantaginis, Petiolus nelumbinis, Radix Morindae Officinalis, Herpetospermum caudigerum Wall. and Radix Urariae crinitae mixing, be placed in pulverizer and be ground into coarse powder, then be the ethanol of 60%-80% with concentration be solvent (be preferably the ethanol of 70% with concentration be solvent), reflux, extract, twice, reflux, extract, 15-25 minute first time (preferred reflux, extract, for the first time 20 minutes), second time reflux, extract, 10-20 minute (preferably second time reflux, extract, 15 minutes), merge twice alcohol extract, filter, filtrate recycling ethanol, being evaporated to 65 DEG C of relative densities is the clear paste of 1.13-1.15, for subsequent use,
(3) by Herba ixeritis debilis, Herba Sedi Aizoon and Herba Euphoubiae Hirtae mixing, the Mel of the Sucus Zingberis and 0.12-0.18 times amount that add 0.5-0.8 times amount is mixed thoroughly (Mel of the Sucus Zingberis and 0.15 times amount that preferably add 0.65 times amount is mixed thoroughly), to in steamer, the supreme gas of Steam by water bath, take out, drying, is together ground into fine powder with Herba Murdanniae Divergentis, Leontopodium leontopodioides (Willd.) Beauv., Herba Desmodii Triquetri (Herba Tadehagi Triquetri) and Petasites japonicus, for subsequent use;
(4) join in step (2) gained clear paste by the crude drug after step (1) and (3) process, spraying dry, get dry extract fine powder, adds adjuvant, stirs, and is pressed into tablet, to obtain final product.
Above-mentioned a kind of preparation method of preventing and treating the Chinese medicinal tablet of nephrotic syndrome, preferred scheme is, in step (4) magnesium stearate of adjuvant to be content be 1.5%-3.5% and content be 3%-7% amylum pregelatinisatum (magnesium stearate and the content of preferred adjuvant to be content be 2%-3% are the amylum pregelatinisatum of 4%-6%, the adjuvant be more preferably to be content be 2.5% magnesium stearate and content be the amylum pregelatinisatum of 5%).
The preparation method of described thick paste agent is:
(1) Rhizoma Dioscoreae shave, is placed in hot sand, and slow fire heats, and fry to medical material surface in light yellow, sieve shakeout, together smashs into fine powder to pieces with Herpetospermum caudigerum Wall., Periostracum Cicadae, Semen Plantaginis, crosses 75-105 mesh sieve (preferred mistake 90 mesh sieve), obtains mixing fine powders, for subsequent use;
(2) Petiolus nelumbinis, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) and Petasites japonicus mixing, add the yellow wine of 0.16-0.2 times amount and the Sucus Zingberis (preferably adding the yellow wine of 0.18 times amount and the Sucus Zingberis of 0.11 times amount) of 0.08-0.14 times amount, mix thoroughly, vexed 10-16 minute (preferably vexed 13 minutes), moderate heat adds to be propagandized hotly to dark brown, takes out dry, for subsequent use;
(3) by Radix Codonopsis, Radix Morindae Officinalis, Leontopodium leontopodioides (Willd.) Beauv. and Radix Urariae crinitae mixing, with second alcohol and water for solvent (volume ratio of second alcohol and water is for 1:4), the amount of solvent is 3-6 times (amount of preferred solvent is 4.5 times of raw material dose) of raw material dose, moderate heat heating decoction twice, each respectively decoction 15-35 minute (preferably each each decoction 25 minutes), filter, merge twice filtrate, reclaim ethanol, being evaporated to 70 DEG C of relative densities is the clear paste of 1.12-1.15, adds step (1) gained mixing fine powders, stirs, obtain thick paste, for subsequent use;
(4) crude drug after step (2) being processed and Herba Murdanniae Divergentis, Fructus Rubi, Herba ixeritis debilis, Herba Sedi Aizoon and Herba Euphoubiae Hirtae are together placed in frying pan, add clear water slow fire boiling twice, first time decocts 24-36 minute (preferably first time decocts 30 minutes), second time decocts 15-25 minute (preferably second time decocts 20 minutes), merge twice decocting liquid, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.20-1.22, for subsequent use;
(5) by step (3) and the mixing of (4) gained thick paste, mix thoroughly, in 92-110 DEG C of sterilizing 35 minutes (being preferable over 100 DEG C of sterilizings 35 minutes), encapsulation, to obtain final product.
Scientific formula of the present invention, preparation method is simple, taking convenience, Be very effective.In addition, excellent results of the present invention also shows:
1,the present invention uses theory of Chinese medical science to analyze prescription composition, and according to each physicochemical property of flavour of a drug ingredient and the result of study of pharmacological action, research obtains the preparation method of reasonable, stable active component;
2,medicine of the present invention supplements and complements each other, and significantly can improve the symptom of nephrotic syndrome, has effect of invigorating the spleen and benefiting QI, the kidney invigorating righting, blood circulation promoting and blood stasis dispelling, clearing away heat and promoting diuresis;
3,curative effect of medication of the present invention is definite, and safe ready, has no side effect, instant effect; Medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Codonopsis: base is former: the dry root that this product is Campanulaceae Radix Codonopsis, element spends Radix Codonopsis or radix codonpsis tangshen.Chemical analysis: Radix Codonopsis root is containing Saponin, Alkaloid, sucrose, glucose, inulin, starch, mucus and resin etc.Nature and flavor: sweet are flat.Gui Jing: return spleen, lung meridian.Effect: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.Cure mainly: for deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Herba Murdanniae Divergentis: base is former: be root or the Herb of Herba Commelinae kind of plant purple back of the body Herba Pyrolae.Nature and flavor: sweet; Micro-hardship; Flat.Function cures mainly: clearing away lung-heat to relieve cough; Invigorating the lung and the kidney; Regulating menstruation, hemostasis.Main cough due to lung-heat; The deficiency of vital energy is breathed with cough; Dizziness and tinnitus; Fracture; Spit blood.
Fructus Rubi: base is former: be the immature fruit of rosaceous plant Fructus Rubi, rubus coreanus etc.Chemical analysis: Fructus Rubi is containing organic acid, saccharide and a small amount of vitamin C.Nature and flavor: sweet acid are flat.Gui Jing: " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enter liver, kidney two warp." function cures mainly: invigorating the liver and kidney, urine reducing, supporing yang, controlling nocturnal emission with astringent drugs, improving eyesight.Control sexual impotence, seminal emission, frequency of micturition, incontinence of urine, asthenia, order is dark.
Herba ixeritis debilis: base is former: be the herb of feverfew Herba ixeritis debilis.Nature and flavor: bitter in the mouth; Cold in nature.Gui Jing: return stomach; Tripe; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Inducing diuresis to remove edema.Main lung abscess; Pharyngalgia; Conjunctival congestion; Mastitis; Ulcer sores; Edema; Dysuria.
Herba Sedi Aizoon: base is former: be the herb of crassulaceae plants Herba Sedi Aizoon.Nature and flavor: " Zhejiang conventional medical herbs among the people ": " property is put down, the micro-acid of sweet in the mouth." function cures mainly: hemostasis, blood stasis dispelling.Control haematemesis, epistaxis, have blood in stool, hematuria, metrorrhagia, traumatic injury.
Semen Plantaginis: base is former: be the seed of Plantaginaceae plant Herba Plantaginis or Plantago depressa Willd.Chemical analysis: containing volume phlegmatic temperament, aucubin, and containing plantenolic acid, choline, adenine, succinic acid, resin etc.Nature and flavor: sweet, cold.Gui Jing: enter kidney, urinary bladder channel.Function cures mainly: diuretic, heat clearing away, tomorrow, eliminates the phlegm.Control urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.
Leontopodium leontopodioides (Willd.) Beauv.: base is former: be the aerial parts of feverfew Leontopodium leontopodioides (Willd.) Beauv..Chemical analysis: herb is containing 3,4-caffeic acid and vanillic acid.Pharmacological action: 1. on the impact of allergic inflammation: Leontopodium alpinum extract lumbar injection 50-100mg/kg reacts the Reversibility passive Arthus of rat, against murine serum.The foot swelling that rabbit anteserum causes, the ecchymosis caused by lysosome, the leukocytoplania that capillary permeability and carboxymethyl cellulose cause all has obvious inhibitory action, and this acts on and does not rely on the complete existence of adrenal gland and lysosome membrane.2. other effects: protocatechualdehyde isolated by Leontopodium leontopodioides (Willd.) Beauv. ethanol extraction, this composition is one of principle active component for the treatment of nephritis, and has the effect increasing coronary flow.Nature and flavor: mildly bitter flavor; Cold in nature.Function cures mainly: wind and heat dispersing; Diuresis; Hemostasis.Main influenza; Anxious; Chronic nephritis; Urinary tract infection; Hematuria; Wound hemorrhage.
Petiolus nelumbinis: base is former: be petiole or the anthocaulus of nymphaeaceae plant lotus.Chemical analysis: Petiolus nelumbinis contains speckle Asia papaverine, the alkaloids such as miltanthin.In addition containing flavonoid glycoside, agedoite, resin and tannin.Nature and flavor: bitter; Property is put down.Gui Jing: spleen; Urinary bladder channel.Function cures mainly: expelling summer-heat heat clearing away; Regulating QI to expel dampness.Main heat-damp in summer is uncomfortable in chest does not relax; Have loose bowels; Dysentery; Gonorrhea; Leukorrhagia.
Herba Desmodii Triquetri (Herba Tadehagi Triquetri): base is former: be the branch and leaf of leguminous plant Herba Desmodii Triquetri (Herba Tadehagi Triquetri), viticula Herba Desmodii Triquetri (Herba Tadehagi Triquetri).Chemical analysis: leaf contains tannin, silicon dioxide, potassium oxide.Pharmacological action: the dull and stereotyped paper disk method of decoct, has inhibitory action to staphylococcus aureus.Differentiate: physicochemical identification gets the broken leaf 10g of this product, with 70% alcohol reflux 2 times, filtration.Filtrate adds hydrochloric acid 3 and zinc powder is a little, solution pinkiness.Nature and flavor: bitter in the mouth; Puckery; Cool in nature.Gui Jing: lung; Liver; Urinary bladder channel.Function cures mainly: heat-clearing and toxic substances removing; Dampness removing jaundice eliminating; Eliminating stagnated food and killing intestinal worms.Main heatstroke excessive thirst; Cold, fever; Laryngopharynx swelling and pain; Pain in the lung hemoptysis; Nephritis; Jaundice; Have loose bowels; Dysentery; Rheumatic arthritis; Infantile malnutrition; Ancylostomiasis; Scabies.
Radix Morindae Officinalis: base is former: this product is the dry root of Maguireothamnus speciosus Radix Morindae Officinalis.Nature and flavor: sweet, pungent, tepor.Gui Jing: return kidney, Liver Channel.Effect: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Cure mainly: for impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.
Herba Euphoubiae Hirtae: base is former: be herb or the whole herb with root of euphorbia plant Ramulus et Folium Bauhiniae Faberi.Chemical analysis: herb is containing freidelin, and β-Amyrin, hentriacontane, cupreol, again containing taraxerol, taraxerone, chondrillasterol, stigmasterol, Jambul alcohol, bark is plain, rhamnetin-3-rhamnoside.Stem contains freidelin, triacontanol, hentriacontanol, taraxerol, hentriacontane, β-Amyrin etc.Leaf is containing gallic acid, quercitrin, arbutin, 3,4-bis--O-gallic acid quininic acid, 2,4,6-tri--O-gallic acid-D-Glucose and 1,2,3,4,6-five-O-gallic acid-β-D-Glucose.Fresh flowers is containing benzoaric acid.Pharmacological action: Female guinea pigs gives Herba Euphoubiae Hirtae before period of sexual maturity, can make mammary gland accelerate to grow and lactogenic.It also has some diuresis, catharsis effect; Without antibacterial action, meaning 1:5-1:60 is also had to have some antibacterial action person.Nature and flavor: pungent; Acid; Frightened; Mild toxicity.Gui Jing: lung; Liver Channel.Function cures mainly: heat-clearing and toxic substances removing; Dampness removing is antipruritic; Lactogenesis.Main lung abscess; Acute mastitis; Dysentery; Have loose bowels; Pyretic stranguria; Hematuria; Eczema; Tinea pedis; Skin pruritus; Furuncle swelling toxin; Ulcerative gingivitis; Puerperal lactation deficiency.
Periostracum Cicadae: base is former: exuviae shell when this product is the nymph emergence of cicada Cryptotympana atrata Fabr..Pharmacological action: 1, anticonvulsant action; 2, sedation; 3, Periostracum Cicadae decoct can block the conduction of cat Superior cervical sympathetic ganglia, on adrenoreceptor and acetylcholine nerve depressor response then without impact.Nature and flavor: sweet, cold.Gui Jing: return lung, Liver Channel.Effect: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.Cure mainly: for anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, conjunctival congestion buckwheat hinders, convulsion with spasms, tetanus.
Herpetospermum caudigerum Wall.: base is former: be the seed of cucurbitaceous plant Fructus Herpetospermi pedunculosi.Chemical analysis: seed is containing ripple rib aldehyde, 4-hydroxy-3-methoxycinnamic alcohol, Fructus Herpetospermi pedunculosi triol, ripple rib triol and ripple rib tetrol.Nature and flavor: bitter in the mouth; Cold in nature.Function cures mainly: liver heat removing function of gallbladder promoting; Spleen invigorating helps fortune.Main icteric infectious hepatitis; Cholecystitis; Dyspepsia.
Petasites japonicus: base is former: be rhizome and the herb of feverfew Petasites japonicus.Chemical analysis: root is containing petasin 50 ~ 55%; also containing carene-3, eremophilene, α-Lignum Santali Albi terpenes, thymol methyl ether, furan eremophilane, ligularone, petasalbin and its angelate, 6-hydroxyeremophilenolide, petasalbin methyl ether, furanofukinol, 6-acetyl furan Petasites japonicus alcohol, 6-angeloyl groups furanofukinol, furanopetasitin, furanojaponin, and choline, protocatechuic acid, angelic acid, caproic acid, sad, cupreol, flavone compound etc.Nature and flavor: " Jiangxi medical herbs ": " toil, cool." function cures mainly: 1. " Jiangxi medical herbs ": " detoxification and removing stasis.Treating tonsillitis, carbuncle furunculosis, venom." 2. " Zhejiang conventional medical herbs among the people ": " reducing swelling and alleviating pain, detoxification and removing stasis.Control traumatic injury, venom.”
Rhizoma Dioscoreae: base is former: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Nature and flavor: sweet are flat.Gui Jing: return spleen, lung, kidney channel.Effect: spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.Cure mainly: for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Radix Urariae crinitae: base is former: the root penetrated for leguminous plant cat tail.Nature and flavor: sweet in the mouth; Warm in nature.Gui Jing: lung; Stomach; Kidney; Liver; Heart channel.Function cures mainly: promoting the circulation of QI to relieve pain; Reduce phlegm by drink.Main heart peratodynia; Cough due to fluid-retention.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1prevent and treat a Chinese medicine preparation for nephrotic syndrome, be prepared from by following bulk drugs, be weight portion (65g/ part): Radix Codonopsis 8 parts; Herba Murdanniae Divergentis 10 parts; Fructus Rubi 6 parts; Herba ixeritis debilis 9 parts; Herba Sedi Aizoon 7 parts; Semen Plantaginis 8 parts; Leontopodium leontopodioides (Willd.) Beauv. 9 parts; Petiolus nelumbinis 7 parts; Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 6 parts; Radix Morindae Officinalis 4 parts; Herba Euphoubiae Hirtae 5 parts; Periostracum Cicadae 3 parts; Herpetospermum caudigerum Wall. 7 parts; Petasites japonicus 9 parts; Rhizoma Dioscoreae (stir-fry) 8 parts; Radix Urariae crinitae 6 parts.
A kind of preparation method of preventing and treating the medicine pill of nephrotic syndrome is:
(1) Radix Morindae Officinalis, Semen Plantaginis and Herpetospermum caudigerum Wall. mixing, the Sucus Zingberis adding 0.2 times amount is mixed thoroughly, and slow fire adds to be propagandized hotly to medical material to be buff, to take out, for subsequent use; Radix Codonopsis and Radix Urariae crinitae mixing, add content be 18% yellow wine mix thoroughly, intense fire adds to be propagandized hotly to medical material surface in yellowish-brown, takes out, for subsequent use;
(2) Periostracum Cicadae is cleaned, and drains, and is placed in 4-5 and becomes the Oleum sesami of heat to explode to golden yellow, take out, suck excess surface oil content, grind as smalls, for subsequent use; Get fresh Fructus Rubi, add the Mel of 0.1 times amount, mix thoroughly, smash into mud to pieces, in 42 DEG C of dryings 2.5 hours, porphyrize, for subsequent use; Rhizoma Dioscoreae shave, is placed in hot sand, and slow fire heats, and fry to medical material surface in light yellow, sieve shakeout, grinds to form fine powder, for subsequent use;
(3) crude drug after step (1) being processed and Herba Murdanniae Divergentis, Herba ixeritis debilis, Leontopodium leontopodioides (Willd.) Beauv., Petasites japonicus and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) are together placed in medicine pot, add clear water and do not have powder, slow fire boiling twice, first time decocts 28 minutes, and second time decocts 16 minutes, filters, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.22-1.25, spraying dry, get dry extract powder, for subsequent use;
(4) Herba Sedi Aizoon, Petiolus nelumbinis fully be dry, pulverize into fine powder with Herba Euphoubiae Hirtae, mix with step (2) gained raw material medicated powder and step (3) gained dried cream powder, cross 115 mesh sieves, with water pill, make the pill of Semen Firmianae size, to obtain final product.
The instructions of taking of gained pill of the present invention is: every day three times, each 4-6 grain, and warm water takes, ten days courses for the treatment of.
Model case: Zhao XX, man, 41 years old, people from Jiangsu.Patient is in occurring abdominal distention without obvious inducement the year before, and two lower limbs edema, playing rear pair of lower limbs edema morning can go down voluntarily, therefore does not attach great importance to and to hospitalize.Patient's edema situation increases the weight of gradually subsequently, goes to local hospital inspection to treat, is diagnosed as nephrotic syndrome, and give albumin input and hormonal medicaments treatment, the state of an illness slightly takes a turn for the better, disease relapse after drug withdrawal and increasing the weight of.Afterwards through making some inquiries about, having the attitude of trying in arms and carrying out my institute's inspection treatment on October 17th, 2012.Check: patient's edema of pair of lower extremities, it is thick that expectorant color measures few matter in vain, and two is just normal; Lab testing: total protein: 40.1g/L, albumin 26.9g/L, globulin 21.2g/L, triglyceride 3.20mmol/L, T-CHOL 15.86mmol/L, low density lipoprotein, LDL 10.58mmol/L, T-CHOL 7.26mmol/L.Be diagnosed as nephrotic syndrome.
Take a kind of medicine pill preventing and treating nephrotic syndrome of the present embodiment gained, instructions of taking: every day three times, each 4-6 grain, warm water takes, ten days courses for the treatment of.After taking two courses for the treatment of, the indexs such as patient's albumin and urine protein all take an evident turn for the better, and other symptoms significantly alleviate; After two courses for the treatment of of continual cure, Urinary albumen is turned out cloudy, urine protein quantitation 0.18g/24h, and edema disappears.Advise and adhere to drug administration, pay a return visit after half a year, each index has no obvious fluctuation, and patient is without any bad complication.
embodiment 2prevent and treat a Chinese medicine preparation for nephrotic syndrome, be prepared from by following bulk drugs, be weight portion (45g/ part): Radix Codonopsis 13 parts; Herba Murdanniae Divergentis 14 parts; Fructus Rubi 9 parts; Herba ixeritis debilis 12 parts; Herba Sedi Aizoon 14 parts; Semen Plantaginis 12 parts; Leontopodium leontopodioides (Willd.) Beauv. 13 parts; Petiolus nelumbinis 15 parts; Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 13 parts; Radix Morindae Officinalis 10 parts; Herba Euphoubiae Hirtae 9 parts; Periostracum Cicadae 9 parts; Herpetospermum caudigerum Wall. 11 parts; Petasites japonicus 14 parts; Rhizoma Dioscoreae (stir-fry) 15 parts; Radix Urariae crinitae 12 parts.
A kind of preparation method of preventing and treating the Chinese medicine decoction of nephrotic syndrome is:
(1) Rhizoma Dioscoreae shave, is placed in hot sand, and slow fire heats, and fry to medical material surface in light yellow, sieve shakeout, grinds to form fine powder, for subsequent use; Herpetospermum caudigerum Wall. and Semen Plantaginis mixing, the Zhenjiang rice vinegar being placed in 1.9 times amount soaks 45 minutes, takes out, is placed on smokeless intense fire and bakes to medical material surface slightly focal spot, takes out, smashs into fine powder to pieces while hot, mix with Rhizoma Dioscoreae powder, crosses 100 mesh sieves, obtains mixed powder, for subsequent use;
(2) Radix Codonopsis and Radix Urariae crinitae mixing, add content be 22% yellow wine mix thoroughly, intense fire adds to be propagandized hotly to medical material surface in yellowish-brown, takes out, for subsequent use;
(3) Petiolus nelumbinis, Fructus Rubi, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Herba Sedi Aizoon, Herba Euphoubiae Hirtae and Petasites japonicus mixing, be placed in marmite, add the cold water of 5.5 times amount, soak 2.3 hours under room temperature, then add step (1) gained mixed powder, big fire heated and boiled 9 minutes, turn little fire and decoct 32 minutes slowly, filter, filtrate is for subsequent use;
(4) crude drug after step (2) being processed mixes with Herba Murdanniae Divergentis, Herba ixeritis debilis, Leontopodium leontopodioides (Willd.) Beauv., Petiolus nelumbinis and Periostracum Cicadae, add water and do not have powder, slow fire boiling twice, each each decoction 24 minutes, merges twice decocting liquid, filters, filtrate and step (3) gained filtrate merge, be evaporated to the half of original volume, sterilizing encapsulates, and to obtain final product.
The instructions of taking of gained decoction of the present invention is: every day three times, each 150-180mL, warmly takes, ten days courses for the treatment of.
embodiment 3prevent and treat a Chinese medicine preparation for nephrotic syndrome, be prepared from by following bulk drugs, be weight portion (60g/ part): Radix Codonopsis 9.5 parts; Herba Murdanniae Divergentis 11 parts; Fructus Rubi 7 parts; Herba ixeritis debilis 10 parts; Herba Sedi Aizoon 9 parts; Semen Plantaginis 9.5 parts; Leontopodium leontopodioides (Willd.) Beauv. 10 parts; Petiolus nelumbinis 9 parts; Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 8 parts; Radix Morindae Officinalis 6 parts; Herba Euphoubiae Hirtae 6 parts; Periostracum Cicadae 4.5 parts; Herpetospermum caudigerum Wall. 8 parts; Petasites japonicus 10 parts; Rhizoma Dioscoreae (stir-fry) 10 parts; Radix Urariae crinitae 8 parts.
A kind of preparation method of preventing and treating the Chinese medicinal tablet of nephrotic syndrome is:
(1) Rhizoma Dioscoreae shave, is placed in hot sand, and slow fire heats, and fry to medical material surface in light yellow, sieve shakeout, grinds to form fine powder, for subsequent use; Periostracum Cicadae is cleaned, and drains, and is placed in 4-5 and becomes the Oleum sesami of heat to explode to golden yellow, take out, suck excess surface oil content, grind as smalls, for subsequent use; The Chinese liquor that Fructus Rubi adds 0.4 times amount is mixed thoroughly, is placed in intense fire on tile and dries, grind to the powder, for subsequent use;
(2) by Radix Codonopsis, Semen Plantaginis, Petiolus nelumbinis, Radix Morindae Officinalis, Herpetospermum caudigerum Wall. and Radix Urariae crinitae mixing, be placed in pulverizer and be ground into coarse powder, then be the ethanol of 70% with concentration be solvent, reflux, extract, twice, first time reflux, extract, 20 minutes, second time reflux, extract, 15 minutes, merge twice alcohol extract, filter, filtrate recycling ethanol, being evaporated to 65 DEG C of relative densities is the clear paste of 1.13-1.15, for subsequent use;
(3) by Herba ixeritis debilis, Herba Sedi Aizoon and Herba Euphoubiae Hirtae mixing, the Mel of the Sucus Zingberis and 0.15 times amount that add 0.65 times amount is mixed thoroughly, in steamer, the supreme gas of Steam by water bath, takes out, dry, together fine powder is ground into Herba Murdanniae Divergentis, Leontopodium leontopodioides (Willd.) Beauv., Herba Desmodii Triquetri (Herba Tadehagi Triquetri) and Petasites japonicus, for subsequent use;
(4) join in step (2) gained clear paste by the crude drug after step (1) and (3) process, spraying dry, get dry extract fine powder, add adjuvant (adjuvant to be content be 2.5% magnesium stearate and content be the amylum pregelatinisatum of 5%), stir, be pressed into tablet, to obtain final product.
The instructions of taking of gained tablet of the present invention is: every day three times, each 3-5 sheet, and warm water takes, ten days courses for the treatment of.
embodiment 4prevent and treat a Chinese medicine preparation for nephrotic syndrome, be prepared from by following bulk drugs, be weight portion (50g/ part): Radix Codonopsis 11.5 parts; Herba Murdanniae Divergentis 13 parts; Fructus Rubi 8 parts; Herba ixeritis debilis 11 parts; Herba Sedi Aizoon 12 parts; Semen Plantaginis 10.5 parts; Leontopodium leontopodioides (Willd.) Beauv. 12 parts; Petiolus nelumbinis 13 parts; Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 11 parts; Radix Morindae Officinalis 8 parts; Herba Euphoubiae Hirtae 8 parts; Periostracum Cicadae 7.5 parts; Herpetospermum caudigerum Wall. 10 parts; Petasites japonicus 13 parts; Rhizoma Dioscoreae (stir-fry) 13 parts; Radix Urariae crinitae 10 parts.
A kind of preparation method of preventing and treating the traditional Chinese medicine thick paste agent of nephrotic syndrome is:
(1) Rhizoma Dioscoreae shave, is placed in hot sand, and slow fire heats, and fry to medical material surface in light yellow, sieve shakeout, together smashs into fine powder to pieces with Herpetospermum caudigerum Wall., Periostracum Cicadae, Semen Plantaginis, crosses 90 mesh sieves, obtains mixing fine powders, for subsequent use;
(2) Petiolus nelumbinis, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) and Petasites japonicus mixing, add the yellow wine of 0.18 times amount and the Sucus Zingberis of 0.11 times amount, mix thoroughly, vexed 13 minutes, moderate heat adds to be propagandized hotly to dark brown, takes out dry, for subsequent use;
(3) by Radix Codonopsis, Radix Morindae Officinalis, Leontopodium leontopodioides (Willd.) Beauv. and Radix Urariae crinitae mixing, with second alcohol and water for solvent (volume ratio of second alcohol and water is for 1:4), the amount of solvent is 4.5 times of raw material dose, moderate heat heating decoction twice, each each decoction 25 minutes, filters, merges twice filtrate, reclaim ethanol, being evaporated to 70 DEG C of relative densities is the clear paste of 1.12-1.15, adds step (1) gained mixing fine powders, stirs, obtain thick paste, for subsequent use;
(4) crude drug after step (2) being processed and Herba Murdanniae Divergentis, Fructus Rubi, Herba ixeritis debilis, Herba Sedi Aizoon and Herba Euphoubiae Hirtae are together placed in frying pan, add clear water slow fire boiling twice, first time decocts 30 minutes, second time decocts 20 minutes, merge twice decocting liquid, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.20-1.22, for subsequent use;
(5) by step (3) and the mixing of (4) gained thick paste, mix thoroughly, in 100 DEG C of sterilizings 35 minutes, encapsulation, to obtain final product.
The instructions of taking of gained thick paste of the present invention agent is: every day three times, each 15-20g, and warm water is taken after mixing it with water, ten days courses for the treatment of.
Model case: Zhu XX, female, 65 years old, people from Henan.Patient has diabetic history 2 years, and take antidiabetic drug always and maintain blood glucose balance, before half a year, edema appears in patient's eyelid, involves two lower limb gradually, with loss of appetite, has blurred vision.Be diagnosed as nephrotic syndrome in local hospital inspection, and give prednisone and and the treatment such as anticoagulant, inducing diuresis to remove edema, treat patient's state of an illness after month and have no improvement, and occur abdominal distention symptom.April 2 in 2013, people went to my institute's treatment.Check: patient's abdominal part slightly bulge, shifting dullness (+), two lower limb pitting edema urine amount is few, yellow skin; Lab testing: total protein 40.2g/L, albumin 25.4g/L, T-CHOL 11.32mmol/L, urine protein quantitation 5.63g/24h, urine protein 5.65g/24h.Be diagnosed as nephrotic syndrome.
Take a kind of traditional Chinese medicine thick paste agent preventing and treating nephrotic syndrome of the present embodiment gained, instructions of taking: every day three times, each 15-20g, warm water is taken after mixing it with water, ten days courses for the treatment of.After taking two courses for the treatment of, the indexs such as patient's albumin and urine protein all take an evident turn for the better, and other symptoms significantly alleviate; After two courses for the treatment of of continual cure, Urinary albumen is turned out cloudy, urine protein quantitation 0.2g/24h, and edema disappears.Advise and adhere to drug administration, pay a return visit after half a year, each index has no obvious fluctuation, and patient is without any bad complication.
embodiment 5prevent and treat a Chinese medicine preparation for nephrotic syndrome, be prepared from by following bulk drugs, be weight portion (55g/ part): Radix Codonopsis 10.5 parts; Herba Murdanniae Divergentis 12 parts; Fructus Rubi 7.5 parts; Herba ixeritis debilis 10.5 parts; Herba Sedi Aizoon 10.5 parts; Semen Plantaginis 10 parts; Leontopodium leontopodioides (Willd.) Beauv. 11 parts; Petiolus nelumbinis 11 parts; Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 9.5 parts; Radix Morindae Officinalis 7 parts; Herba Euphoubiae Hirtae 7 parts; Periostracum Cicadae 6 parts; Herpetospermum caudigerum Wall. 9 parts; Petasites japonicus 11.5 parts; Rhizoma Dioscoreae (stir-fry) 11.5 parts; Radix Urariae crinitae 9 parts.
A kind of preparation method of preventing and treating the medicine pill of nephrotic syndrome is:
(1) Radix Morindae Officinalis, Semen Plantaginis and Herpetospermum caudigerum Wall. mixing, the Sucus Zingberis adding 0.3 times amount is mixed thoroughly, and slow fire adds to be propagandized hotly to medical material to be buff, to take out, for subsequent use; Radix Codonopsis and Radix Urariae crinitae mixing, add content be 22% yellow wine mix thoroughly, intense fire adds to be propagandized hotly to medical material surface in yellowish-brown, takes out, for subsequent use;
(2) Periostracum Cicadae is cleaned, and drains, and is placed in 4-5 and becomes the Oleum sesami of heat to explode to golden yellow, take out, suck excess surface oil content, grind as smalls, for subsequent use; Get fresh Fructus Rubi, add the Mel of 0.15 times amount, mix thoroughly, smash into mud to pieces, in 50 DEG C of dryings 3.5 hours, porphyrize, for subsequent use; Rhizoma Dioscoreae shave, is placed in hot sand, and slow fire heats, and fry to medical material surface in light yellow, sieve shakeout, grinds to form fine powder, for subsequent use;
(3) crude drug after step (1) being processed and Herba Murdanniae Divergentis, Herba ixeritis debilis, Leontopodium leontopodioides (Willd.) Beauv., Petasites japonicus and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) are together placed in medicine pot, add clear water and do not have powder, slow fire boiling twice, first time decocts 35 minutes, and second time decocts 23 minutes, filters, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.22-1.25, spraying dry, get dry extract powder, for subsequent use;
(4) Herba Sedi Aizoon, Petiolus nelumbinis fully be dry, pulverize into fine powder with Herba Euphoubiae Hirtae, mix with step (2) gained raw material medicated powder and step (3) gained dried cream powder, cross 130 mesh sieves, with water pill, make the pill of Semen Firmianae size, to obtain final product.
The instructions of taking of gained pill of the present invention is: every day three times, each 4-6 grain, and warm water takes, ten days courses for the treatment of.
test example 1a kind of clinical practice preventing and treating the Chinese medicine preparation (embodiment 5) of nephrotic syndrome of gained of the present invention:
1. data and method
1.1 physical data
Choose the patient being diagnosed as nephrotic syndrome totally 335 examples of my institute treatment in May ,-2012 in June, 2010, wherein male 179 example, women 156 example, the age 20-60 year, 45.5 ± 2.5 years old mean age, the course of disease was at 6 months-3 years.
1.2 diagnostic criteria
All patients all meet following standard: (1) High-grade Proteinuria (> 3.5g/24h); (2) hypoproteinemia (albumin < 30g/L); (3) obvious edema is had; (4) hyperlipemia is had.Wherein (1) and (2) item by diagnosis required.And get rid of the Secondary cases such as lupus nephritis, diabetic nephropathy nephrotic syndrome.
1.3 Therapeutic Method
All patients take a kind of Chinese medicine preparation preventing and treating nephrotic syndrome of gained of the present invention, instructions of taking: every day three times, each 4-6 grain, and warm water takes, ten days courses for the treatment of.Observe four courses for the treatment of of treatment altogether.Observe the clinical symptoms of patient and the situation of change of albuminuria, serum albumin etc.
1.4 curative effect determinate standard
Effective: to measure urine protein more than 3 times negative, urine protein quantitation < 0.2g/24h, serum protein levels is normal or close normal;
Effective: measure urine protein < 0.2g/24h for more than 3 times, serum protein levels is improved;
Invalid: clinical symptoms has no and alleviates, or do not reach above standard person.
(total effective rate=obvious effective rate+effective percentage)
1.5 therapeutic outcome
Therapeutic outcome is as shown in table 1.
Table 1: the therapeutic outcome taking Patients With Nephrotic Symdrome after product of the present invention
The present invention select Radix Codonopsis, Herba Murdanniae Divergentis, Fructus Rubi, Herba ixeritis debilis, Herba Sedi Aizoon, Semen Plantaginis, Leontopodium leontopodioides (Willd.) Beauv. and Petiolus nelumbinis etc. totally 16 taste primary raw materials be prepared from.Fang Zhong, Radix Codonopsis has invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting; Herba Murdanniae Divergentis clearing away lung-heat to relieve cough, invigorating the lung and the kidney, regulating menstruation, hemostasis; Herba ixeritis debilis heat-clearing and toxic substances removing, inducing diuresis to remove edema; Herba Sedi Aizoon is stopped blooding, blood stasis dispelling; Petiolus nelumbinis regulating QI to expel dampness; Herba Desmodii Triquetri (Herba Tadehagi Triquetri) heat-clearing and toxic substances removing, dampness removing jaundice eliminating; Herba Euphoubiae Hirtae heat-clearing and toxic substances removing, dampness removing is antipruritic; Herpetospermum caudigerum Wall. liver heat removing function of gallbladder promoting, spleen invigorating helps fortune; Radix Urariae crinitae promoting the circulation of QI to relieve pain, reduce phlegm by drink.All medicines share, and play the effects such as invigorating the spleen and benefiting QI, the kidney invigorating righting, blood circulation promoting and blood stasis dispelling, clearing away heat and promoting diuresis altogether.After treating four courses for the treatment of, total effective rate is 98.5%; Urine protein and the serum albumin index for the treatment of Patients Before And After are all significantly improved.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. prevent and treat a Chinese medicine preparation for nephrotic syndrome, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Codonopsis 8-13; Herba Murdanniae Divergentis 10-14; Fructus Rubi 6-9; Herba ixeritis debilis 9-12; Herba Sedi Aizoon 7-14; Semen Plantaginis 8-12; Leontopodium leontopodioides (Willd.) Beauv. 9-13; Petiolus nelumbinis 7-15; Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 6-13; Radix Morindae Officinalis 4-10; Herba Euphoubiae Hirtae 5-9; Periostracum Cicadae 3-9; Herpetospermum caudigerum Wall. 7-11; Petasites japonicus 9-14; Rhizoma Dioscoreae (stir-fry) 8-15; Radix Urariae crinitae 6-12.
2. a kind of Chinese medicine preparation preventing and treating nephrotic syndrome as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Codonopsis 9.5-11.5; Herba Murdanniae Divergentis 11-13; Fructus Rubi 7-8; Herba ixeritis debilis 10-11; Herba Sedi Aizoon 9-12; Semen Plantaginis 9.5-10.5; Leontopodium leontopodioides (Willd.) Beauv. 10-12; Petiolus nelumbinis 9-13; Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 8-11; Radix Morindae Officinalis 6-8; Herba Euphoubiae Hirtae 6-8; Periostracum Cicadae 4.5-7.5; Herpetospermum caudigerum Wall. 8-10; Petasites japonicus 10-13; Rhizoma Dioscoreae (stir-fry) 10-13; Radix Urariae crinitae 8-10.
3. a kind of Chinese medicine preparation preventing and treating nephrotic syndrome as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Codonopsis 10.5; Herba Murdanniae Divergentis 12; Fructus Rubi 7.5; Herba ixeritis debilis 10.5; Herba Sedi Aizoon 10.5; Semen Plantaginis 10; Leontopodium leontopodioides (Willd.) Beauv. 11; Petiolus nelumbinis 11; Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 9.5; Radix Morindae Officinalis 7; Herba Euphoubiae Hirtae 7; Periostracum Cicadae 6; Herpetospermum caudigerum Wall. 9; Petasites japonicus 11.5; Rhizoma Dioscoreae (stir-fry) 11.5; Radix Urariae crinitae 9.
4. a kind of preparation method of preventing and treating the medicine pill of nephrotic syndrome as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) Radix Morindae Officinalis, Semen Plantaginis and Herpetospermum caudigerum Wall. mixing, the Sucus Zingberis adding 0.2-0.4 times amount is mixed thoroughly (Sucus Zingberis preferably adding 0.3 times amount is mixed thoroughly), and slow fire adds to be propagandized hotly to medical material to be buff, to take out, for subsequent use; Radix Codonopsis and Radix Urariae crinitae mixing, add content be the yellow wine of 18%-26% mix thoroughly (preferably add content be 22% yellow wine mix thoroughly), intense fire adds to be propagandized hotly to medical material surface in yellowish-brown, takes out, for subsequent use;
(2) Periostracum Cicadae is cleaned, and drains, and is placed in 4-5 and becomes the Oleum sesami of heat to explode to golden yellow, take out, suck excess surface oil content, grind as smalls, for subsequent use; Get fresh Fructus Rubi, add the Mel (preferably adding the Mel of 0.15 times amount) of 0.1-0.2 times amount, mix thoroughly, smash into mud to pieces, dry, porphyrize, for subsequent use; Rhizoma Dioscoreae shave, is placed in hot sand, and slow fire heats, and fry to medical material surface in light yellow, sieve shakeout, grinds to form fine powder, for subsequent use;
(3) crude drug after step (1) being processed and Herba Murdanniae Divergentis, Herba ixeritis debilis, Leontopodium leontopodioides (Willd.) Beauv., Petasites japonicus and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) are together placed in medicine pot, add clear water and do not have powder, slow fire boiling twice, first time decocts 28-42 minute (preferably first time decocts 35 minutes), and second time decocts 16-30 minute (preferably second time decocts 23 minutes), filters, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.22-1.25, spraying dry, get dry extract powder, for subsequent use;
(4) Herba Sedi Aizoon, Petiolus nelumbinis fully be dry, pulverize into fine powder with Herba Euphoubiae Hirtae, mix with step (2) gained raw material medicated powder and step (3) gained dried cream powder, cross 115-145 mesh sieve (preferred mistake 130 mesh sieve), with water pill, make the pill of Semen Firmianae size, to obtain final product.
5. a kind of preparation method of preventing and treating the medicine pill of nephrotic syndrome according to claim 4, is characterized in that, temperature dry in step (2) is 42-56 DEG C (preferred dry temperature is 46-52 DEG C, and the temperature of the drying be more preferably is 50 DEG C).
6. a kind of preparation method of preventing and treating the medicine pill of nephrotic syndrome according to claim 4, it is characterized in that, time dry in step (2) is 2.5-4.5 hour (the preferred dry time is 3-4 hour, and the time of the drying be more preferably is 3.5 hours).
7. a kind of preparation method of preventing and treating the Chinese medicine decoction of nephrotic syndrome as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) Rhizoma Dioscoreae shave, is placed in hot sand, and slow fire heats, and fry to medical material surface in light yellow, sieve shakeout, grinds to form fine powder, for subsequent use; Herpetospermum caudigerum Wall. and Semen Plantaginis mixing, the Zhenjiang rice vinegar being placed in 1.6-2.2 times amount soaks 35-55 minute (the Zhenjiang rice vinegar being preferably placed in 1.9 times amount soaks 45 minutes), take out, being placed on smokeless intense fire bakes to medical material surface slightly focal spot, takes out, smashs into fine powder to pieces while hot, mix with Rhizoma Dioscoreae powder, cross 85-115 mesh sieve (preferred mistake 100 mesh sieve), obtain mixed powder, for subsequent use;
(2) Radix Codonopsis and Radix Urariae crinitae mixing, add content be the yellow wine of 18%-26% mix thoroughly (preferably add content be 22% yellow wine mix thoroughly), intense fire adds to be propagandized hotly to medical material surface in yellowish-brown, takes out, for subsequent use;
(3) Petiolus nelumbinis, Fructus Rubi, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Herba Sedi Aizoon, Herba Euphoubiae Hirtae and Petasites japonicus mixing, be placed in marmite, add the cold water (preferably adding the cold water of 5.5 times amount) of 4.5-6.5 times amount, soak under room temperature 1.6-3.0 hour (soaking 2.3 hours under being preferable over room temperature), then add step (1) gained mixed powder, big fire heated and boiled 6-12 minute (preferred big fire heated and boiled 9 minutes), turn little fire and decoct slowly 25-38 minute (preferably turn little fire and decoct 32 minutes slowly), filter, filtrate is for subsequent use;
(4) crude drug after step (2) being processed mixes with Herba Murdanniae Divergentis, Herba ixeritis debilis, Leontopodium leontopodioides (Willd.) Beauv., Petiolus nelumbinis and Periostracum Cicadae, add water and do not have powder, slow fire boiling twice, each respectively decoction 18-30 minute (preferably each each decoction 24 minutes), merges twice decocting liquid, filtration, filtrate and step (3) gained filtrate merge, be evaporated to the half of original volume, sterilizing encapsulates, and to obtain final product.
8. a kind of preparation method of preventing and treating the Chinese medicinal tablet of nephrotic syndrome as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) Rhizoma Dioscoreae shave, is placed in hot sand, and slow fire heats, and fry to medical material surface in light yellow, sieve shakeout, grinds to form fine powder, for subsequent use; Periostracum Cicadae is cleaned, and drains, and is placed in 4-5 and becomes the Oleum sesami of heat to explode to golden yellow, take out, suck excess surface oil content, grind as smalls, for subsequent use; Fructus Rubi adds the Chinese liquor of 0.3-0.5 times amount and mixes thoroughly (Chinese liquor that preferred Fructus Rubi adds 0.4 times amount is mixed thoroughly), is placed in intense fire on tile and dries, grind to the powder, for subsequent use;
(2) by Radix Codonopsis, Semen Plantaginis, Petiolus nelumbinis, Radix Morindae Officinalis, Herpetospermum caudigerum Wall. and Radix Urariae crinitae mixing, be placed in pulverizer and be ground into coarse powder, then be the ethanol of 60%-80% with concentration be solvent (be preferably the ethanol of 70% with concentration be solvent), reflux, extract, twice, reflux, extract, 15-25 minute first time (preferred reflux, extract, for the first time 20 minutes), second time reflux, extract, 10-20 minute (preferably second time reflux, extract, 15 minutes), merge twice alcohol extract, filter, filtrate recycling ethanol, being evaporated to 65 DEG C of relative densities is the clear paste of 1.13-1.15, for subsequent use,
(3) by Herba ixeritis debilis, Herba Sedi Aizoon and Herba Euphoubiae Hirtae mixing, the Mel of the Sucus Zingberis and 0.12-0.18 times amount that add 0.5-0.8 times amount is mixed thoroughly (Mel of the Sucus Zingberis and 0.15 times amount that preferably add 0.65 times amount is mixed thoroughly), to in steamer, the supreme gas of Steam by water bath, take out, drying, is together ground into fine powder with Herba Murdanniae Divergentis, Leontopodium leontopodioides (Willd.) Beauv., Herba Desmodii Triquetri (Herba Tadehagi Triquetri) and Petasites japonicus, for subsequent use;
(4) join in step (2) gained clear paste by the crude drug after step (1) and (3) process, spraying dry, get dry extract fine powder, adds adjuvant, stirs, and is pressed into tablet, to obtain final product.
9. a kind of preparation method of preventing and treating the Chinese medicinal tablet of nephrotic syndrome according to claim 8, it is characterized in that, in step (4) magnesium stearate of adjuvant to be content be 1.5%-3.5% and content be 3%-7% amylum pregelatinisatum (magnesium stearate and the content of preferred adjuvant to be content be 2%-3% are the amylum pregelatinisatum of 4%-6%, the adjuvant be more preferably to be content be 2.5% magnesium stearate and content be the amylum pregelatinisatum of 5%).
10. a kind of preparation method of preventing and treating the traditional Chinese medicine thick paste agent of nephrotic syndrome as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) Rhizoma Dioscoreae shave, is placed in hot sand, and slow fire heats, and fry to medical material surface in light yellow, sieve shakeout, together smashs into fine powder to pieces with Herpetospermum caudigerum Wall., Periostracum Cicadae, Semen Plantaginis, crosses 75-105 mesh sieve (preferred mistake 90 mesh sieve), obtains mixing fine powders, for subsequent use;
(2) Petiolus nelumbinis, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) and Petasites japonicus mixing, add the yellow wine of 0.16-0.2 times amount and the Sucus Zingberis (preferably adding the yellow wine of 0.18 times amount and the Sucus Zingberis of 0.11 times amount) of 0.08-0.14 times amount, mix thoroughly, vexed 10-16 minute (preferably vexed 13 minutes), moderate heat adds to be propagandized hotly to dark brown, takes out dry, for subsequent use;
(3) by Radix Codonopsis, Radix Morindae Officinalis, Leontopodium leontopodioides (Willd.) Beauv. and Radix Urariae crinitae mixing, with second alcohol and water for solvent (volume ratio of second alcohol and water is for 1:4), the amount of solvent is 3-6 times (amount of preferred solvent is 4.5 times of raw material dose) of raw material dose, moderate heat heating decoction twice, each respectively decoction 15-35 minute (preferably each each decoction 25 minutes), filter, merge twice filtrate, reclaim ethanol, being evaporated to 70 DEG C of relative densities is the clear paste of 1.12-1.15, adds step (1) gained mixing fine powders, stirs, obtain thick paste, for subsequent use;
(4) crude drug after step (2) being processed and Herba Murdanniae Divergentis, Fructus Rubi, Herba ixeritis debilis, Herba Sedi Aizoon and Herba Euphoubiae Hirtae are together placed in frying pan, add clear water slow fire boiling twice, first time decocts 24-36 minute (preferably first time decocts 30 minutes), second time decocts 15-25 minute (preferably second time decocts 20 minutes), merge twice decocting liquid, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.20-1.22, for subsequent use;
(5) by step (3) and the mixing of (4) gained thick paste, mix thoroughly, in 92-110 DEG C of sterilizing 35 minutes (being preferable over 100 DEG C of sterilizings 35 minutes), encapsulation, to obtain final product.
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| CN105288043A (en) * | 2015-10-29 | 2016-02-03 | 李连庆 | Preparation for treating nephrotic syndrome and preparing method |
| CN105288044A (en) * | 2015-10-29 | 2016-02-03 | 李连庆 | Traditional Chinese medicine composition mainly for treating nephrotic syndromes and preparation method thereof |
| CN105288129A (en) * | 2015-10-29 | 2016-02-03 | 李连庆 | Traditional Chinese medicine composition for preventing and treating nephrotic syndrome and preparation method thereof |
| CN106109650A (en) * | 2016-07-21 | 2016-11-16 | 刘静丽 | A kind of alleviate the enema medicament of frequent micturition after childbirth |
| CN107669933A (en) * | 2017-11-09 | 2018-02-09 | 徐莉 | It is used for pharmaceutical composition for soothing nerves and preparation method thereof on a kind of psychiatric nursing |
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Cited By (5)
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| CN105288043A (en) * | 2015-10-29 | 2016-02-03 | 李连庆 | Preparation for treating nephrotic syndrome and preparing method |
| CN105288044A (en) * | 2015-10-29 | 2016-02-03 | 李连庆 | Traditional Chinese medicine composition mainly for treating nephrotic syndromes and preparation method thereof |
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| CN106109650A (en) * | 2016-07-21 | 2016-11-16 | 刘静丽 | A kind of alleviate the enema medicament of frequent micturition after childbirth |
| CN107669933A (en) * | 2017-11-09 | 2018-02-09 | 徐莉 | It is used for pharmaceutical composition for soothing nerves and preparation method thereof on a kind of psychiatric nursing |
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