CN105287355A - Acne removing and skin beautifying essence liquid and preparation method thereof - Google Patents
Acne removing and skin beautifying essence liquid and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The present invention belongs to the technical field of cosmetics, and particularly relates to an acne removing and skin beautifying essence liquid and a preparation method thereof, wherein the essence liquid comprises an acne removing component, and the acne removing component comprises a phellodendron amurense tree bark extract and a rosa multiflora fruit extract. According to the present invention, the acne removing component is obtained through screening; the new acne removing component can effectively inhibit Propionibacterium acnes, and the test research results show that the product provides a good acne treating effect and a good whitening effect after the acne removing component is added to the essence liquid; and the stability research results show that the essence liquid has good stability.
Description
Technical field
The invention belongs to cosmetic technical field, be specifically related to a kind of anti-acne maintenance essence and preparation method thereof.
Background technology
Acne is that a kind of pilosebaceous chronic inflammatory skin is sick, and be mainly in face, chest and back, more common at adolescence, main morbidity form is comedo, acne.Acne has various skin damage form, and comprise acne, pimple, pustule, tuberosity etc., therefore, acne is all commonly encountered diseases and the frequently-occurring disease of department of dermatologry all the time.The cause of disease of acne is comparatively complicated, and the factors such as modern medicine thinks that the pathogenesis of acne is main and hypersteatosis, pilosebaceous duct block, bacteriological infection and inflammatory reaction are closely related.After adolescing, in human body, the content of androgen particularly testosterone raises rapidly, promotes that sebaceous gland is grown and produces a large amount of sebum.The dyskeratosis of pilosebaceous duct causes catheter blockage, dyssebacia simultaneously, forms horn plug and micropowder thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction in hair follicle, the lipase decomposition sebum that propionibacterium acnes produces generates free fatty, chemotactic inflammatory cell and medium simultaneously, final induction also exacerbate inflammation reaction.It is long that acne has the course of disease, and the feature of easily recurrence, long-standing problem vast teenager.
At present, the method for Acne treatment has a lot, is main, also comprises minority external used medicine mainly with oral drugs.Oral mode mainly utilizes systemic blood circulation to carry out Formulations for systemic administration, to reach effect of Acne treatment, the general course for the treatment of longer, poor effect.External mode is many by smearing external used medicine at disease sites or cosmetics carry out Acne treatment, medicine can be directly acted on human body face by cosmetic applying, make medicine fully and facial contact and infiltrate skin fast, the time of contact of effective prolong drug and skin, improve skin to the degree of absorption of medicine, significantly shorten treatment cycle.
But, mostly containing the chemical composition such as hydrargyrum, fruit acid in the cosmetics of Acne treatment in the market, easily cause the untoward reaction such as skin allergy, injured cutaneous tissue structure, therapeutic effect is unsatisfactory, although Chinese herbal medicine cosmetic few in number is nontoxic non-stimulated, but often therapeutic effect is single, only there is sterilization, biocidal efficacies, cannot in time detumescence and apocenosis and repair impression, therapeutic effect is not good.Therefore, study new can the cosmetics of Acne treatment, significant for patients with acne.
Summary of the invention
For these reasons, applicant is through years of researches, obtain a kind of not only there is whitening function but also there is the essence (namely having the essence of Acne treatment effect) of anti-acne effect newly, containing anti-acne composition in this essence, anti-acne composition comprises: pungent yellow tiller bark extract, Fructus Rosae Davuricae extract, more preferably yellow tiller bark extract, Fructus Rosae Davuricae extract, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, Tremella extract.Anti-acne composition of the present invention is obtained by screening, the new anti-acne composition of the present invention effectively can suppress propionibacterium acnes, and add in essence by anti-acne composition, experimental study shows, for acne, there is good therapeutical effect, there is good whitening function simultaneously.Stability study shows, essence of the present invention has better stability.
The present invention is achieved through the following technical solutions.
A kind of essence, essence comprises anti-acne composition, and anti-acne composition comprises yellow tiller bark extract, Fructus Rosae Davuricae extract.
Described anti-acne composition is preferably: yellow tiller bark extract, Fructus Rosae Davuricae extract, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, Tremella extract.
Wherein yellow tiller bark extract 0.005-0.015 weight portion, Fructus Rosae Davuricae extract 0.01-0.02 weight portion.
Wherein yellow tiller bark extract 0.005-0.015 weight portion, Fructus Rosae Davuricae extract 0.01-0.02 weight portion, Radix Astragali root extract 0.05-0.15 weight portion, Rhizoma Atractylodis Macrocephalae root extract 0.05-0.15 weight portion, Bupleurum krylovianum root extract 0.05-0.15 weight portion, Tremella extract 0.04-0.06 weight portion.
Described essence raw material comprises: 1, 2-pentanediol, glycerol, 1, 3-butanediol, betanin, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, allantoin, carbomer, sodium hydroxide, pentetic acid five sodium, EDTA-disodium, resveratrol, phytic acid, hydrolysis Lac regis apis albumen, squalane, spermol, 1, ammediol, macadimia nut seed oil, silver oxide, plant sterol/octyl dodecanol lauroyl glutamate ester, myristyl alcohol, denatonium benzoate, two (lauramide glutamine) L-Lysine sodium salt, phytosphingosine, Cer AP II, ceramide 3, Cer EOS, cholesterol, yellow tiller bark extract, Fructus Rosae Davuricae extract, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, Tremella extract.
Described essence raw material comprises: 1,2-pentanediol 4-6 weight portion, glycerol 2.5-4 weight portion, 1,3 butylene glycol 0.5-1.5 weight portion, betanin 0.4-0.6 weight portion, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.20-0.30 weight portion, allantoin 0.1-0.3 weight portion, carbomer 0.1-0.3 weight portion, sodium hydroxide 0.1 weight portion, pentetic acid five sodium 0.01 weight portion, EDTA-disodium 0.01 weight portion, resveratrol 0.003 weight portion, phytic acid 0.0012 weight portion, hydrolysis Lac regis apis albumen 0.001125 weight portion, squalane 0.0005 weight portion, spermol 0.0004 weight portion, 1,3-PD 0.00025 weight portion, macadimia nut seed oil 0.00015 weight portion, silver oxide 0.00011 weight portion, plant sterol/octyl dodecanol lauroyl glutamate ester 0.0001 weight portion, myristyl alcohol 0.0001 weight portion, denatonium benzoate 0.00002 weight portion, two (lauramide glutamine) L-Lysine sodium salt 0.0000075 weight portion, phytosphingosine 0.0000025 weight portion, Cer AP II0.0000025 weight portion, ceramide 3 0.0000025 weight portion, Cer EOS 0.00000005 weight portion, cholesterol 0.0000025 weight portion, yellow tiller bark extract 0.005-0.015 weight portion, Fructus Rosae Davuricae extract 0.01-0.02 weight portion, Radix Astragali root extract 0.05-0.15 weight portion, Rhizoma Atractylodis Macrocephalae root extract 0.05-0.15 weight portion, Bupleurum krylovianum root extract 0.05-0.15 weight portion, Tremella extract 0.04-0.06 weight portion.
The preparation method of described essence:
(1) water intaking, 1,2-pentanediol, glycerol, allantoin, carbomer, EDTA-disodium, add agitated kettle, after being heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(2) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add water, 1, 3-butanediol, yellow tiller bark extract, Fructus Rosae Davuricae extract, betanin, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, glycerol, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, pentetic acid five sodium, phytic acid, silver oxide, sodium hydroxide, Tremella extract, hydrolysis Lac regis apis albumen, 1, ammediol, ceramide 3, Cer AP II, Cer EOS, phytosphingosine, cholesterol, myristyl alcohol, spermol, plant sterol/octyl dodecanol lauroyl glutamate ester, two (lauramide glutamine) L-Lysine sodium salt, squalane, macadimia nut, resveratrol, denatonium benzoate, continue to stir, be cooled to room temperature, fill, to obtain final product.
Following is purchase producer and the lot number of part material of the present invention:
Detailed description of the invention
Below in conjunction with example, the present invention is elaborated.Following examples do not limit protection scope of the present invention.
Following test, be on the basis of repeatedly creative test, for the claimed content of the present invention, the concluding of carrying out is tested.
One, screening test: to the inhibitory action of propionibacterium acnes
Test 1 group: yellow tiller bark extract.
Test 2 groups: Fructus Rosae Davuricae extract.
Test 3 groups: yellow tiller bark extract 0.01g, Fructus Rosae Davuricae extract 0.015g.
Test 4 groups: yellow tiller bark extract 0.01g, Fructus Rosae Davuricae extract 0.015g, Radix Astragali root extract 0.1g.
Test 5 groups: yellow tiller bark extract 0.01g, Fructus Rosae Davuricae extract 0.015g, Radix Astragali root extract 0.1g, Bupleurum krylovianum root extract 0.1g.
Test 6 groups: yellow tiller bark extract 0.01g, Fructus Rosae Davuricae extract 0.015g, Radix Astragali root extract 0.1g, Rhizoma Atractylodis Macrocephalae root extract 0.1g, Bupleurum krylovianum root extract 0.1g, Tremella extract 0.05g.
Sample preparation: get above-mentioned test group raw material, add 50mL deionized water, then add 50mL1,3-butanediol, mix homogeneously, for subsequent use.
Test method: collection of specimens: choose patients with acne skin lesion (pustule, typical acne), after iodine tincture, alcohol disinfecting, extrudes content with the acne extruder of sterilization, moves into stuart transporting culture medium immediately.
The cultivation of anaerobe, Isolation and Identification: the specimen be inoculated on transporting culture medium is sent into Microbiological Lab immediately, be inoculated in THIO culture medium, uses airbag method, and be placed in 37 DEG C of cultivation 72h in anaerobic jar, make indicator with methylene blue, palladium grain is catalyst.According to colonial morphology, microscopy is gram-positive bacteria, and be bar-shaped or tennis-racket-shaped more, carries out preliminary identification, then the single bacterium colony of picking, and turn 2 pieces of flat boards, one piece is placed in anaerobic jar, the lower 37 DEG C of pure cultures of anaerobic condition; Another block is with 37 DEG C of aerobic cultivations; Observed result after 48h, the flat board seeing Anaerobic culturel occurs form is homogeneous, bacterium colony that canescence, the circle that tiny, diameter is about 1mm projection, edge are slightly neat, without bacterial growth under aerobic cultivation; Bacterium colony is made microscopy, visible chromabacterium biolaceum under mirror, micro-curved in bar-shaped or shaft-like, can the blunt circle in one end, one end attenuates, and painted dark, cell is single, can arrange in pairs or arrange as the shape such as " people ", " V ".Again through oxytolerant test, catalase test, indole test, biochemical serial test for identification be propionibacterium acnes.
Secondary culture P.acne is inoculated in LB fluid medium, opaque is found after 37 DEG C of aerobic cultivation 24h, get bacterium liquid in a ring fluid medium and make microscopy, and observe discovery after coating dull and stereotyped 24h, flat-plate bacterial colony form, Gram's staining and Microscopic observation characteristic of bacteria, catalase test, indole test, oxytolerant are tested, biochemical results is consistent with front.
Anaerobism drug sensitive test: inoculation: a picking 1-2 colony inoculation on LB plating medium, 37 DEG C of aerobic cultivation 24h, by aerobic cultivation 24h purebred P.acne physiological saline solution rinse, flushing liquor puts into sterile test tube; Adopt Maxwell turbidimetry than turbid, opacity tube with front needing jolting 10-12 time, first than turbid to 3*10
8/ mL, then with normal saline dilution to 10
5-10
6/ mL is for subsequent use.LB plating medium is inoculated: the swab stick of sterilizing is dipped bacterium liquid, squeezes and removes unnecessary bacterium liquid, even spread on LB plating medium, and sweep a circle along plate edge ring, build plate, dry 2-3min on tube wall.Aseptic steel bowl (diameter is 6mm) is put down gently on plating medium, fills it up with ready sample liquid, put into 37 DEG C of aerobic cultivation 24h, find that plate is interior without bacterial growth, after continuing 37 DEG C of aerobic cultivation 24h, see have inhibition zone to be formed.
Survey antibacterial circle diameter, 4 groups of antibacterial circle diameter values are averaged by result of determination, antibacterial susceptibility grade classification: it is quick in Gao Min, 10-20mm that inhibition zone diameter is greater than 20mm, and being less than 10mm is drug resistance.
Result of the test: in table 1.
The antibacterial Comparative result result of table 1
Conclusion (of pressure testing): above-mentioned result of the test shows, test 1 group, test 2 groups and do not produce fungistatic effect, and add after yellow tiller bark extract and Fructus Rosae Davuricae extract combination, in generation quick antibacterial (testing 3 groups), and after adding Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, Tremella extract, bacteriostatic diameter increases, therefore, test 3 groups and test 6 groups, can use as anti-acne composition.
Two, demonstration test: to the experimental study of rabbit ear Acne Model therapeutical effect
Test 1 group: 1,2-pentanediol 4g, glycerol 2.5g, 1,3 butylene glycol 0.5g, betanin 0.4g, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.20g, allantoin 0.1g, carbomer 0.1g, sodium hydroxide 0.1g, pentetic acid five sodium 0.01g, EDTA-disodium 0.01g, resveratrol 0.003g, phytic acid 0.0012g, hydrolysis Lac regis apis albumen 0.001125g, squalane 0.0005g, spermol 0.0004g, 1,3-PD 0.00025g, macadimia nut seed oil 0.00015g, silver oxide 0.00011g, octyl dodecanol lauroyl glutamate ester 0.0001g, myristyl alcohol 0.0001g, denatonium benzoate 0.00002g, two (lauramide glutamine) L-Lysine sodium salt 0.0000075g, phytosphingosine 0.0000025g, Cer AP II0.0000025g, ceramide 3 0.0000025g, Cer EOS 0.00000005g weight portion, cholesterol 0.0000025g, yellow tiller bark extract 0.005g, Fructus Rosae Davuricae extract 0.01g, Radix Astragali root extract 0.05g, Rhizoma Atractylodis Macrocephalae root extract 0.05g, Bupleurum krylovianum root extract 0.05g, Tremella extract 0.04g.
The preparation method of essence:
(1) water intaking 71g, 1,2-pentanediol, glycerol 1.2g, allantoin, carbomer, EDTA-disodium, adds agitated kettle, after being heated to 70-75 DEG C, stirs, in suction vacuum emulsifying machine;
(2) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add water 11g, 1, 3-butanediol, yellow tiller bark extract, Fructus Rosae Davuricae extract, betanin, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, glycerol 1.3g, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, pentetic acid five sodium, phytic acid, silver oxide, sodium hydroxide, Tremella extract, hydrolysis Lac regis apis albumen, 1, ammediol, ceramide 3, Cer AP II, Cer EOS, phytosphingosine, cholesterol, myristyl alcohol, spermol, octyl dodecanol lauroyl glutamate ester, two (lauramide glutamine) L-Lysine sodium salt, squalane, macadimia nut, resveratrol, denatonium benzoate, continue to stir, be cooled to room temperature, fill, to obtain final product.
Test 2 groups: 1,2-pentanediol 5g, glycerol 3.2g, 1,3 butylene glycol 1g, betanin 0.5g, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.25g, allantoin 0.2g, carbomer 0.2g, sodium hydroxide 0.1g, pentetic acid five sodium 0.01g, EDTA-disodium 0.01g, resveratrol 0.003g, phytic acid 0.0012g, hydrolysis Lac regis apis albumen 0.001125g, squalane 0.0005g, spermol 0.0004g, 1,3-PD 0.00025g, macadimia nut seed oil 0.00015g, silver oxide 0.00011g, octyl dodecanol lauroyl glutamate ester 0.0001g, myristyl alcohol 0.0001g, denatonium benzoate 0.00002g, two (lauramide glutamine) L-Lysine sodium salt 0.0000075g, phytosphingosine 0.0000025g, Cer AP II0.0000025g, ceramide 3 0.0000025g, Cer EOS 0.00000005g, cholesterol 0.0000025g, yellow tiller bark extract 0.01g, Fructus Rosae Davuricae extract 0.015g, Radix Astragali root extract 0.1g, Rhizoma Atractylodis Macrocephalae root extract 0.1g, Bupleurum krylovianum root extract 0.1g, Tremella extract 0.05g.
The preparation method of essence:
(1) water intaking 77g, 1,2-pentanediol, glycerol 1.5g, allantoin, carbomer, EDTA-disodium, adds agitated kettle, after being heated to 70-75 DEG C, stirs, in suction vacuum emulsifying machine;
(2) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add water 12g, 1, 3-butanediol, yellow tiller bark extract, Fructus Rosae Davuricae extract, betanin, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, glycerol 1.7g, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, pentetic acid five sodium, phytic acid, silver oxide, sodium hydroxide, Tremella extract, hydrolysis Lac regis apis albumen, 1, ammediol, ceramide 3, Cer AP II, Cer EOS, phytosphingosine, cholesterol, myristyl alcohol, spermol, plant sterol/octyl dodecanol lauroyl glutamate ester, two (lauramide glutamine) L-Lysine sodium salt, squalane, macadimia nut, resveratrol, denatonium benzoate, continue to stir, be cooled to room temperature, fill, to obtain final product.
Test 3 groups: 1,2-pentanediol 6g, glycerol 4g, 1,3 butylene glycol 1.5g, betanin 0.6g, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.30g, allantoin 0.3g, carbomer 0.3g, sodium hydroxide 0.1g, pentetic acid five sodium 0.01g, EDTA-disodium 0.01g, resveratrol 0.003g part, phytic acid 0.0012g, hydrolysis Lac regis apis albumen 0.001125g, squalane 0.0005g, spermol 0.0004g, 1,3-PD 0.00025g, macadimia nut seed oil 0.00015g, silver oxide 0.00011g, octyl dodecanol lauroyl glutamate ester 0.0001g, myristyl alcohol 0.0001g, denatonium benzoate 0.00002g, two (lauramide glutamine) L-Lysine sodium salt 0.0000075g, phytosphingosine 0.0000025g, Cer AP II0.0000025g, ceramide 3 0.0000025g, Cer EOS 0.00000005g, cholesterol 0.0000025g, yellow tiller bark extract 0.015g, Fructus Rosae Davuricae extract 0.02g, Radix Astragali root extract 0.15g, Rhizoma Atractylodis Macrocephalae root extract 0.15g, Bupleurum krylovianum root extract 0.15g, Tremella extract 0.05g.
The preparation method of essence:
(1) water intaking 80g, 1,2-pentanediol, glycerol 1.7g, allantoin, carbomer, EDTA-disodium, adds agitated kettle, after being heated to 70-75 DEG C, stirs, in suction vacuum emulsifying machine;
(2) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add water 12g, 1, 3-butanediol, yellow tiller bark extract, Fructus Rosae Davuricae extract, betanin, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, glycerol 2.3g, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, pentetic acid five sodium, phytic acid, silver oxide, sodium hydroxide, Tremella extract, hydrolysis Lac regis apis albumen, 1, ammediol, ceramide 3, Cer AP II, Cer EOS, phytosphingosine, cholesterol, myristyl alcohol, spermol, plant sterol/octyl dodecanol lauroyl glutamate ester, two (lauramide glutamine) L-Lysine sodium salt, squalane, macadimia nut, resveratrol, denatonium benzoate, continue to stir, be cooled to room temperature, fill, to obtain final product.
Experimental animal: Adult New Zealand large ear rabbit, weight 2.0 ~ 3.0kg.
Test method: year New Zealand's large ear rabbit auris dextra inboard ear tube opening place 2cm × 2cm scope, 0.25mL to be once coated with coal tar diluent (the 2% concentration liquor carbonis detergens that 95% ethanol is made into) every day, left ear is left intact as a comparison, after perusal modeling, the situation of rabbit ear skin lesion and follicular orifice are with or without horn plug etc., connect and are coated with 14d.Get 2 Adult New Zealand large ear rabbits at random, put to death with air tap inserting method, take off the full thickness skin at ears catheter opening place, 10% formalin solution is fixed, and embeds, then cut into slices and dry after dehydration with hard wax.Routine pathology observation is carried out, checking modeling success after HE dyeing.
Curative effect naked eyes criterion: normal (0): normal structure, without acne.Slightly (I grade): acne are main skin lesion, can have a small amount of pimple and pustule.Total focus number is less than 30.Moderate (II ~ III grade): wherein II grade has acne, with pimple and the pustule of moderate.Total focus number is between 31 ~ 50; A large amount of pimple and pustule is accompanied for III grade, accidental large inflammatory damage on acne basis, widely distributed, there is minority tuberosity to be formed.Total focus number is between 51 ~ 100.Severe (IV grade) except above-mentioned skin lesion, also with tuberosity or the cyst of more than 3.
Get modeling success rear New Zealand large ear rabbit, random selecting is divided into 4 groups more at random: blank group, test group, often organizes 6.Respectively after above-mentioned criterion classification, test group gives essence twice every day, each 1mL, and blank group is coated with deionized water outward, every day 1 time, each 1mL.The recovery situation of perusal rabbit ear skin lesion after 14d.
Result of the test: in table 2.
Perusal statistics before and after table 2 rabbit ear coating
Conclusion (of pressure testing): above-mentioned test shows, essence of the present invention has good therapeutical effect to rabbit ear acne, absolutely proves, essence of the present invention has good anti-acne effect.
Three, whitening experimental study
Test specimen: with test two
Test specimen is prepared: get 1,3 butylene glycol 5g, add water 5g, and mixing completely.Get test 1 group of essence 1g, add in above-mentioned solvent, mixing is completely, for subsequent use; Test 2 groups, test 3 groups, compound method is the same.
Test method: get human body skin threedimensional model test box (MEL-300B).According to this test operation flow process, threedimensional model is moved in 6 porocyte culture plates, be placed in 37 DEG C, 5%CO by long term maintenance culture medium (EPI-100LLMM)
2lower calorstat preculture, after 1 hour, adds different tests group, adds preparing test specimen 100 μ L to horny layer side respectively, the blank group of 1,3 butylene glycol aqueous solution adding equivalent.Basal layer side uses long term maintenance culture medium to continue to cultivate.The interval of 2 days or 3 days exchanges the cultivation that culture medium and tested material are carried out 16 days altogether.After cultivation, after washing skin histology by PBS (-) buffering, MX18 (manufacture of Courage+Khazaka company) is utilized to test the Mai Laning value of different group.
Result of the test: in table 3.
The Mai Laning value of table 3 different tests group
| Test group | Mai Laning value (a.u.) |
| Blank group | 491.03±1.2 |
| Test 1 group | 315.79±0.8*** |
| Test 2 groups | 299.46±1.0*** |
| Test 3 groups | 312.46±0.8*** |
Conclusion (of pressure testing): above-mentioned test shows, essence of the present invention has good whitening function.
Four, stability test
Test 1 group: 1,2-pentanediol 5g, glycerol 3.2g, 1,3 butylene glycol 1g, betanin 0.5g, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.25g, allantoin 0.2g, carbomer 0.2g, sodium hydroxide 0.1g, pentetic acid five sodium 0.01g, EDTA-disodium 0.01g, resveratrol 0.003g, phytic acid 0.0012g, hydrolysis Lac regis apis albumen 0.001125g, squalane 0.0005g, spermol 0.0004g, 1,3-PD 0.00025g, macadimia nut seed oil 0.00015g, silver oxide 0.00011g, octyl dodecanol lauroyl glutamate ester 0.0001g, myristyl alcohol 0.0001g, denatonium benzoate 0.00002g, two (lauramide glutamine) L-Lysine sodium salt 0.0000075g, phytosphingosine 0.0000025g, Cer AP II0.0000025g, ceramide 3 0.0000025g, Cer EOS 0.00000005g, cholesterol 0.0000025g, yellow tiller bark extract 0.01g, Fructus Rosae Davuricae extract 0.015g, Radix Astragali root extract 0.1g, Rhizoma Atractylodis Macrocephalae root extract 0.1g, Bupleurum krylovianum root extract 0.1g, Tremella extract 0.05g.
The preparation method of essence:
(1) water intaking 77g, 1,2-pentanediol, glycerol 1.5g, allantoin, carbomer, EDTA-disodium, adds agitated kettle, after being heated to 70-75 DEG C, stirs, in suction vacuum emulsifying machine;
(2) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add water 12g, 1, 3-butanediol, yellow tiller bark extract, Fructus Rosae Davuricae extract, betanin, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, glycerol 1.7g, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, pentetic acid five sodium, phytic acid, silver oxide, sodium hydroxide, Tremella extract, hydrolysis Lac regis apis albumen, 1, ammediol, ceramide 3, Cer AP II, Cer EOS, phytosphingosine, cholesterol, myristyl alcohol, spermol, plant sterol/octyl dodecanol lauroyl glutamate ester, two (lauramide glutamine) L-Lysine sodium salt, squalane, macadimia nut, resveratrol, denatonium benzoate, continue to stir, be cooled to room temperature, fill, to obtain final product.
Test 2 groups: 1,2-pentanediol 5g, glycerol 3.2g, 1,3 butylene glycol 1g, betanin 0.5g, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.25g, allantoin 0.2g, carbomer 0.2g, sodium acetate 0.2g, pentetic acid five sodium 0.01g, EDTA-disodium 0.01g, resveratrol 0.003g, phytic acid 0.0012g, hydrolysis Lac regis apis albumen 0.001125g, squalane 0.0005g, spermol 0.0004g, 1,3-PD 0.00025g, macadimia nut seed oil 0.00015g, silver oxide 0.00011g, octyl dodecanol lauroyl glutamate ester 0.0001g, myristyl alcohol 0.0001g, denatonium benzoate 0.00002g, two (lauramide glutamine) L-Lysine sodium salt 0.0000075g, phytosphingosine 0.0000025g, Cer AP II0.0000025g, ceramide 3 0.0000025g, Cer EOS 0.00000005g, cholesterol 0.0000025g, yellow tiller bark extract 0.01g, Fructus Rosae Davuricae extract 0.015g, Radix Astragali root extract 0.1g, Rhizoma Atractylodis Macrocephalae root extract 0.1g, Bupleurum krylovianum root extract 0.1g, Tremella extract 0.05g.
The preparation method of essence:
(1) water intaking 77g, 1,2-pentanediol, glycerol 1.5g, allantoin, carbomer, EDTA-disodium, adds agitated kettle, after being heated to 70-75 DEG C, stirs, in suction vacuum emulsifying machine;
(2) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add water 12g, 1, 3-butanediol, yellow tiller bark extract, Fructus Rosae Davuricae extract, betanin, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, glycerol 1.7g, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, pentetic acid five sodium, phytic acid, silver oxide, sodium acetate, Tremella extract, hydrolysis Lac regis apis albumen, 1, ammediol, ceramide 3, Cer AP II, Cer EOS, phytosphingosine, cholesterol, myristyl alcohol, spermol, plant sterol/octyl dodecanol lauroyl glutamate ester, two (lauramide glutamine) L-Lysine sodium salt, squalane, macadimia nut, resveratrol, denatonium benzoate, continue to stir, be cooled to room temperature, fill, to obtain final product.
Whether whether test method: get essence, is placed in 40 DEG C and deposits 24h, deposit 24h, then deposit 24h in-5 DEG C in room temperature, circulates 3 times successively, observe and have layering, oil slick, color and luster to change.
Conclusion (of pressure testing): in table 4.
Table 4 stability test result
| Group | Whether layering | Whether oil slick | Whether color and luster changes |
| Test 1 group | Have | Have | No |
| Test 2 groups | No | Have | Have |
Conclusion (of pressure testing): after adding sodium acetate in essence, essence, after cold cycling, produces layering and oil slick phenomenon, and tests 1 group and do not produce such phenomenon, absolutely proves that essence prescription stability of the present invention is better.
Preparation embodiment
Embodiment 1
Essence prescription is: 1,2-pentanediol 4g, glycerol 2.5g, 1,3 butylene glycol 0.5g, betanin 0.4g, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.20g, allantoin 0.1g, carbomer 0.1g, sodium hydroxide 0.1g, pentetic acid five sodium 0.01g, EDTA-disodium 0.01g, resveratrol 0.003g, phytic acid 0.0012g, hydrolysis Lac regis apis albumen 0.001125g, squalane 0.0005g, spermol 0.0004g, 1,3-PD 0.00025g, macadimia nut seed oil 0.00015g, silver oxide 0.00011g, octyl dodecanol lauroyl glutamate ester 0.0001g, myristyl alcohol 0.0001g, denatonium benzoate 0.00002g, two (lauramide glutamine) L-Lysine sodium salt 0.0000075g, phytosphingosine 0.0000025g, Cer AP II0.0000025g, ceramide 3 0.0000025g, Cer EOS 0.00000005g weight portion, cholesterol 0.0000025g, yellow tiller bark extract 0.005g, Fructus Rosae Davuricae extract 0.01g, Radix Astragali root extract 0.05g, Rhizoma Atractylodis Macrocephalae root extract 0.05g, Bupleurum krylovianum root extract 0.05g, Tremella extract 0.04g.
The preparation method of essence:
(1) water intaking 71g, 1,2-pentanediol, glycerol 1.2g, allantoin, carbomer, EDTA-disodium, adds agitated kettle, after being heated to 70-75 DEG C, stirs, in suction vacuum emulsifying machine;
(2) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add water 11g, 1, 3-butanediol, yellow tiller bark extract, Fructus Rosae Davuricae extract, betanin, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, glycerol 1.3g, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, pentetic acid five sodium, phytic acid, silver oxide, sodium hydroxide, Tremella extract, hydrolysis Lac regis apis albumen, 1, ammediol, ceramide 3, Cer AP II, Cer EOS, phytosphingosine, cholesterol, myristyl alcohol, spermol, octyl dodecanol lauroyl glutamate ester, two (lauramide glutamine) L-Lysine sodium salt, squalane, macadimia nut, resveratrol, denatonium benzoate, continue to stir, be cooled to room temperature, fill, to obtain final product.
Embodiment 2
Essence prescription is: 1,2-pentanediol 5g, glycerol 3.2g, 1,3 butylene glycol 1g, betanin 0.5g, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.25g, allantoin 0.2g, carbomer 0.2g, sodium hydroxide 0.1g, pentetic acid five sodium 0.01g, EDTA-disodium 0.01g, resveratrol 0.003g, phytic acid 0.0012g, hydrolysis Lac regis apis albumen 0.001125g, squalane 0.0005g, spermol 0.0004g, 1,3-PD 0.00025g, macadimia nut seed oil 0.00015g, silver oxide 0.00011g, octyl dodecanol lauroyl glutamate ester 0.0001g, myristyl alcohol 0.0001g, denatonium benzoate 0.00002g, two (lauramide glutamine) L-Lysine sodium salt 0.0000075g, phytosphingosine 0.0000025g, Cer AP II0.0000025g, ceramide 3 0.0000025g, Cer EOS 0.00000005g, cholesterol 0.0000025g, yellow tiller bark extract 0.01g, Fructus Rosae Davuricae extract 0.015g, Radix Astragali root extract 0.1g, Rhizoma Atractylodis Macrocephalae root extract 0.1g, Bupleurum krylovianum root extract 0.1g, Tremella extract 0.05g.
The preparation method of essence:
(1) water intaking 77g, 1,2-pentanediol, glycerol 1.5g, allantoin, carbomer, EDTA-disodium, adds agitated kettle, after being heated to 70-75 DEG C, stirs, in suction vacuum emulsifying machine;
(2) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add water 12g, 1, 3-butanediol, yellow tiller bark extract, Fructus Rosae Davuricae extract, betanin, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, glycerol 1.7g, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, pentetic acid five sodium, phytic acid, silver oxide, sodium hydroxide, Tremella extract, hydrolysis Lac regis apis albumen, 1, ammediol, ceramide 3, Cer AP II, Cer EOS, phytosphingosine, cholesterol, myristyl alcohol, spermol, plant sterol/octyl dodecanol lauroyl glutamate ester, two (lauramide glutamine) L-Lysine sodium salt, squalane, macadimia nut, resveratrol, denatonium benzoate, continue to stir, be cooled to room temperature, fill, to obtain final product.
Embodiment 3
Essence prescription is: 1,2-pentanediol 6g, glycerol 4g, 1,3 butylene glycol 1.5g, betanin 0.6g, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.30g, allantoin 0.3g, carbomer 0.3g, sodium hydroxide 0.1g, pentetic acid five sodium 0.01g, EDTA-disodium 0.01g, resveratrol 0.003g part, phytic acid 0.0012g, hydrolysis Lac regis apis albumen 0.001125g, squalane 0.0005g, spermol 0.0004g, 1,3-PD 0.00025g, macadimia nut seed oil 0.00015g, silver oxide 0.00011g, octyl dodecanol lauroyl glutamate ester 0.0001g, myristyl alcohol 0.0001g, denatonium benzoate 0.00002g, two (lauramide glutamine) L-Lysine sodium salt 0.0000075g, phytosphingosine 0.0000025g, Cer AP II0.0000025g, ceramide 3 0.0000025g, Cer EOS 0.00000005g, cholesterol 0.0000025g, yellow tiller bark extract 0.015g, Fructus Rosae Davuricae extract 0.02g, Radix Astragali root extract 0.15g, Rhizoma Atractylodis Macrocephalae root extract 0.15g, Bupleurum krylovianum root extract 0.15g, Tremella extract 0.05g.
The preparation method of essence:
(1) water intaking 80g, 1,2-pentanediol, glycerol 1.7g, allantoin, carbomer, EDTA-disodium, adds agitated kettle, after being heated to 70-75 DEG C, stirs, in suction vacuum emulsifying machine;
(2) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add water 12g, 1, 3-butanediol, yellow tiller bark extract, Fructus Rosae Davuricae extract, betanin, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, glycerol 2.3g, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, pentetic acid five sodium, phytic acid, silver oxide, sodium hydroxide, Tremella extract, hydrolysis Lac regis apis albumen, 1, ammediol, ceramide 3, Cer AP II, Cer EOS, phytosphingosine, cholesterol, myristyl alcohol, spermol, plant sterol/octyl dodecanol lauroyl glutamate ester, two (lauramide glutamine) L-Lysine sodium salt, squalane, macadimia nut, resveratrol, denatonium benzoate, continue to stir, be cooled to room temperature, fill, to obtain final product.
Preparation embodiment includes but not limited to above-mentioned.
Claims (7)
1. an essence, is characterized in that essence comprises anti-acne composition, and anti-acne composition comprises yellow tiller bark extract, Fructus Rosae Davuricae extract.
2. a kind of essence according to claim 1, wherein anti-acne composition is: yellow tiller bark extract, Fructus Rosae Davuricae extract, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, Tremella extract.
3. a kind of essence according to claim 1, wherein yellow tiller bark extract 0.005-0.015 weight portion, Fructus Rosae Davuricae extract 0.01-0.02 weight portion.
4. a kind of essence according to claim 2, wherein yellow tiller bark extract 0.005-0.015 weight portion, Fructus Rosae Davuricae extract 0.01-0.02 weight portion, Radix Astragali root extract 0.05-0.15 weight portion, Rhizoma Atractylodis Macrocephalae root extract 0.05-0.15 weight portion, Bupleurum krylovianum root extract 0.05-0.15 weight portion, Tremella extract 0.04-0.06 weight portion.
5. a kind of essence according to claim 2 or 4, it is characterized in that essence raw material comprises: 1, 2-pentanediol, glycerol, 1, 3-butanediol, betanin, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, allantoin, carbomer, sodium hydroxide, pentetic acid five sodium, EDTA-disodium, resveratrol, phytic acid, hydrolysis Lac regis apis albumen, squalane, spermol, 1, ammediol, macadimia nut seed oil, silver oxide, plant sterol/octyl dodecanol lauroyl glutamate ester, myristyl alcohol, denatonium benzoate, two (lauramide glutamine) L-Lysine sodium salt, phytosphingosine, Cer AP II, ceramide 3, Cer EOS, cholesterol, yellow tiller bark extract, Fructus Rosae Davuricae extract, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, Tremella extract.
6. a kind of essence according to claim 2 or 4, is characterized in that essence raw material comprises: 1,2-pentanediol 4-6 weight portion, glycerol 2.5-4 weight portion, 1,3 butylene glycol 0.5-1.5 weight portion, betanin 0.4-0.6 weight portion, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.2-0.3 weight portion, allantoin 0.1-0.3 weight portion, carbomer 0.1-0.3 weight portion, sodium hydroxide 0.1 weight portion, pentetic acid five sodium 0.01 weight portion, EDTA-disodium 0.01 weight portion, resveratrol 0.003 weight portion, phytic acid 0.0012 weight portion, hydrolysis Lac regis apis albumen 0.001125 weight portion, squalane 0.0005 weight portion, spermol 0.0004 weight portion, 1,3-PD 0.00025 weight portion, macadimia nut seed oil 0.00015 weight portion, silver oxide 0.00011 weight portion, plant sterol/octyl dodecanol lauroyl glutamate ester 0.0001 weight portion, myristyl alcohol 0.0001 weight portion, denatonium benzoate 0.00002 weight portion, two (lauramide glutamine) L-Lysine sodium salt 0.0000075 weight portion, phytosphingosine 0.0000025 weight portion, Cer AP II0.0000025 weight portion, ceramide 3 0.0000025 weight portion, Cer EOS 0.00000005 weight portion, cholesterol 0.0000025 weight portion, yellow tiller bark extract 0.005-0.015 weight portion, Fructus Rosae Davuricae extract 0.01-0.02 weight portion, Radix Astragali root extract 0.05-0.15 weight portion, Rhizoma Atractylodis Macrocephalae root extract 0.05-0.15 weight portion, Bupleurum krylovianum root extract 0.05-0.15 weight portion, Tremella extract 0.04-0.06 weight portion.
7. a kind of essence according to claim 6, is characterized in that the preparation method of essence:
(1) water intaking, 1,2-pentanediol, glycerol, allantoin, carbomer, EDTA-disodium, add agitated kettle, after being heated to 70-75 DEG C, stir, in suction vacuum emulsifying machine;
(2) start is uniformly mixed, and 30 minutes, 1000rpm/ divided, and stops stirring, is cooled to 40 DEG C, add water, 1, 3-butanediol, yellow tiller bark extract, Fructus Rosae Davuricae extract, betanin, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, glycerol, Radix Astragali root extract, Rhizoma Atractylodis Macrocephalae root extract, Bupleurum krylovianum root extract, pentetic acid five sodium, phytic acid, silver oxide, sodium hydroxide, Tremella extract, hydrolysis Lac regis apis albumen, 1, ammediol, ceramide 3, Cer AP II, Cer EOS, phytosphingosine, cholesterol, myristyl alcohol, spermol, plant sterol/octyl dodecanol lauroyl glutamate ester, two (lauramide glutamine) L-Lysine sodium salt, squalane, macadimia nut, resveratrol, denatonium benzoate, continue to stir, be cooled to room temperature, fill, to obtain final product.
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| CN105919876A (en) * | 2016-06-12 | 2016-09-07 | 马殿伟 | Traditional Chinese medicine composition containing cerasusssp and applied to acne removing cosmetics |
| CN107213101A (en) * | 2017-06-23 | 2017-09-29 | 芜湖凌梦电子商务有限公司 | A kind of Essence containing Chinese medical extract |
| CN107496285A (en) * | 2017-08-25 | 2017-12-22 | 郭青华 | A kind of whelk patient Essence and preparation method thereof |
| CN108498427A (en) * | 2018-06-11 | 2018-09-07 | 广东芭薇生物科技股份有限公司 | A kind of high osmosis moisturizing emulsion and preparation method thereof |
| CN109200275A (en) * | 2018-11-23 | 2019-01-15 | 杭州炬九生物科技有限公司 | A kind of Medical cold application for micro- whole rear easing pain and diminishing inflammation promoting healing |
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| CN110354012A (en) * | 2019-08-20 | 2019-10-22 | 无限极（中国）有限公司 | Composition and bath preparation containing the composition |
| CN111840098A (en) * | 2019-04-16 | 2020-10-30 | 广州爱妃丽尔化妆品科技有限公司 | Novel anti-oxidation essence containing fullerene and preparation process thereof |
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| CN105919876A (en) * | 2016-06-12 | 2016-09-07 | 马殿伟 | Traditional Chinese medicine composition containing cerasusssp and applied to acne removing cosmetics |
| CN107213101A (en) * | 2017-06-23 | 2017-09-29 | 芜湖凌梦电子商务有限公司 | A kind of Essence containing Chinese medical extract |
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| CN107496285A (en) * | 2017-08-25 | 2017-12-22 | 郭青华 | A kind of whelk patient Essence and preparation method thereof |
| CN108498427A (en) * | 2018-06-11 | 2018-09-07 | 广东芭薇生物科技股份有限公司 | A kind of high osmosis moisturizing emulsion and preparation method thereof |
| CN108498427B (en) * | 2018-06-11 | 2021-03-16 | 广东芭薇生物科技股份有限公司 | High-permeability moisturizing emulsion and preparation method thereof |
| CN109200275A (en) * | 2018-11-23 | 2019-01-15 | 杭州炬九生物科技有限公司 | A kind of Medical cold application for micro- whole rear easing pain and diminishing inflammation promoting healing |
| CN111840098A (en) * | 2019-04-16 | 2020-10-30 | 广州爱妃丽尔化妆品科技有限公司 | Novel anti-oxidation essence containing fullerene and preparation process thereof |
| CN110354012A (en) * | 2019-08-20 | 2019-10-22 | 无限极（中国）有限公司 | Composition and bath preparation containing the composition |
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