CN105267695A - Ganoderma lucidum spore powder compound product for improving anti-tumor curative effects and method for preparing ganoderma lucidum spore powder compound product - Google Patents
Ganoderma lucidum spore powder compound product for improving anti-tumor curative effects and method for preparing ganoderma lucidum spore powder compound product Download PDFInfo
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Abstract
The invention discloses a ganoderma lucidum spore powder compound product for improving anti-tumor curative effects and a method for preparing the ganoderma lucidum spore powder compound product, and relates to the technical field of traditional Chinese medicine healthcare products. The ganoderma lucidum spore powder compound product comprises sporoderm-broken ganoderma lucidum spore powder, ganoderma lucidum, dendrobium officinale, barbary wolfberry fruits, cornus officinalis powder, astragalus, cordyceps militaris, radix adenophorae powder, radix ophiopogonis powder, lentinan, paclitaxel, rhodiola and moringa seed powder. The ganoderma lucidum spore powder compound product and the method have the advantages that synergistic effects can be realized by the ganoderma lucidum spore powder and other traditional Chinese ingredients, composite treatment effects of traditional Chinese medicine compounds can be realized, comprehensive anti-tumor effects of the ganoderma lucidum can be sufficiently realized, accordingly, effects of tonifying primordial qi, boosting vital essence, benefiting joints and strengthening muscles and bones can be realized by the ganoderma lucidum spore powder compound product, the ganoderma lucidum spore powder compound product can be used for anti-fatigue, anti-oxidation, anti-aging and anti-tumor treatment, toxic and side effects of radiotherapy and chemotherapy can eliminated, the immunity of users can be improved, and the ganoderma lucidum spore powder compound product is particularly greatly beneficial to rehabilitation of middle-aged and elderly people after various diseases are treated, improvement of immune functions and strengthening of physique.
Description
Technical field
The present invention relates to Chinese medicine health care product technical field, be specifically related to a kind of Ganoderma spore powder compound product strengthening antitumor curative effect and preparation method thereof.
Background technology
" put prevention first ", " preventing trouble before it happens " is the state basic policy of China's health service and health care, research and development have raising immunologic function, antineoplastic compound Chinese medicinal preparation, be urgent task and the study hotspot of vast medical sci-tech worker, in natural Chinese medicinal herb, effective component extracting is an important channel of anti-cancer agent exploitation.
Ganoderma is a kind of medicinal fungi, records according to Shennong's Herbal, Ganoderma " standby alive for evermore for a long time ".Last century the seventies, scientist finds Ganoderma, Ganoderma spore powder has antitumor action, this start in China America and Japan, Han Deng state rapidly Ganoderma, Ganoderma spore powder research upsurge.People thought that the ganoderan in Ganoderma, Ganoderma spore powder was anti-tumor activity composition always in the past, can improve immune function of human body.Until 90 year later stage, but China scientist tests and confirms that active ingredient in Ganoderma spore powder can activating cancer cell Caspaseization enzyme, causes cancerous cell to wither, can regulate again P53gene, can also active cell channel protein P38, thus there is antineoplastic action.Shanghai University, London department of medial science of Royal Academy Ludwig ICR, U.S. Scripps grind also all prove that Ganoderma spore powder can suppress the activity of oncogene, cancer cell specific induction of apoptosis by specificity.Xu Chuan university of Japan, Slaan-Keteering DKFZ of American Academy of Sciences confirms: Ganoderma spore powder can make hepatoma carcinoma cell reverse.More than test proof, Ganoderma spore powder, by having an effect to crucial target spot multiple in signal, regulates oncogene and antioncogene, and cancer cell specific induction of apoptosis or short cancerous tumor cell reverse.But at present, Ganoderma or Ganoderma spore powder are mainly used alone, and products material is single, act on single, depart from chinese herbal compound plyability treatment advantage, failed effectively to play comprehensive antitumor effectiveness of Ganoderma.
Summary of the invention
(1) technical problem solved
For the deficiencies in the prior art, the invention provides a kind of Ganoderma spore powder compound product strengthening antitumor curative effect and preparation method thereof, compound product of the present invention, Ganoderma spore powder can with other Chinese medicine ingredients synergism, there is the advantage of Chinese Traditional Medicine compound recipe plyability treatment, given full play to the comprehensive antitumor effectiveness of Ganoderma.
(2) technical scheme
For realizing above object, the present invention is achieved by the following technical programs:
Strengthen a Ganoderma spore powder compound product for antitumor curative effect, be made up of the raw material of following weight portion: Ganoderma spore powder with cellular wall broken 80-130 part, Herba Dendrobii 80-100 part, Ganoderma 60-70 part, Fructus Lycii 45-55 part, powder of Fructus Corni 65-85 part, Radix Astragali 24-38 part, Cordyceps militaris (L.) Link. 10-24 part, Radix Adenophorae (Radix Glehniae) powder 30-40 part, Radix Ophiopogonis powder 20-30 part, lentinan 20-30 part, taxol 5-10 part, Radix Rhodiolae 6-20 part, moringa seeds powder 5-14 part.
Preferably, the Ganoderma spore powder compound product of described enhancing antitumor curative effect is made up of the raw material of following weight portion: Ganoderma spore powder with cellular wall broken 100-120 part, Herba Dendrobii 85-95 part, Ganoderma 62-70 part, Fructus Lycii 48-55 part, powder of Fructus Corni 70-80 part, Radix Astragali 28-34 part, Cordyceps militaris (L.) Link. 14-20 part, Radix Adenophorae (Radix Glehniae) powder 30-40 part, Radix Ophiopogonis powder 22-30 part, lentinan 23-27 part, taxol 7-9 part, Radix Rhodiolae 9-17 part, moringa seeds powder 7-14 part.
Preferably, the Ganoderma spore powder compound product of described enhancing antitumor curative effect is made up of the raw material of following weight portion: Ganoderma spore powder with cellular wall broken 110 parts, Herba Dendrobii 90 parts, Ganoderma 65 parts, Fructus Lycii 50 parts, powder of Fructus Corni 75 parts, the Radix Astragali 31 parts, Cordyceps militaris (L.) Link. 17 parts, 36 parts, Radix Adenophorae (Radix Glehniae) powder, Radix Ophiopogonis powder 25 parts, lentinan 25 parts, taxol 8 parts, Radix Rhodiolae 13 parts, 10 parts, moringa seeds powder.
Preferably, described compound product is capsule, tablet or oral liquid.
Strengthen a preparation method for the Ganoderma spore powder compound product of antitumor curative effect, comprise the following steps:
S1, select operable Herba Dendrobii branch, clean, drain, cutting, drier after freezing, then use pulverizer superfine grinding, take the Herba Dendrobii lyophilized powder produced according to weight portion, for subsequent use;
S2, choose the measured raw material of clean and dried matter again, take raw material according to weight portion, for subsequent use;
S3, by ready raw material mixing in step S1 and S2, add water 80-110 DEG C of 5-10 times amount by the weight of mixture and decoct 1-3h, decocts 1-3 time, merging decoction liquor, filtration, obtains filtrate;
S4, the filtrate obtained by step S2, be concentrated into paste, obtain thick paste, and by thick paste, the 2-5 amount doubly of weight adds the ethanol water that volume fraction is 55-65%, stirs 10-30min, leaves standstill, get supernatant, decompression recycling ethanol, obtain extractum, for subsequent use;
S5, the extractum obtained by step S3 are granulated, 60 DEG C of drying under reduced pressure 2-4 hour, granulate, and cross 20 mesh sieves, filled capsules, obtains capsule; Or the extractum obtained by step S3 is granulated, and dry 1-2 hour at 55-65 DEG C, then carries out tabletting, obtain tablet on tablet machine; Or the extractum spraying dry obtained by step S3, obtains fine powder, then after being dissolved in water by fine powder, add 2% sucrose, then add water to 500ml, mixing, filter, fill, sterilizing.
Preferably, decocting temperature described in step S3 is 105 DEG C, and decocting time is 2h.
(3) beneficial effect
The invention provides a kind of Ganoderma spore powder compound product strengthening antitumor curative effect and preparation method thereof, there is following beneficial effect:
(1) the present invention adopts Ganoderma spore powder with cellular wall broken to replace traditional Ganoderma spore powder, and be conducive to the release of most active component in Ganoderma spore powder, its antitumor curative effect is more remarkable;
(2) Ganoderma spore powder of the present invention can with other Chinese medicine ingredients synergism, have Chinese Traditional Medicine compound recipe plyability treatment advantage, given full play to the comprehensive antitumor effectiveness of Ganoderma;
(3) the present invention has invigorating primordial QI, benefit vital essence, profit joint, effect of hard muscles and bones, can be used for resisting fatigue, antioxidation, defying age, antitumor, can eliminate the toxic and side effects of radiotherapy, chemotherapy, increase immunity, especially to the various rehabilitation after being ill of middle-aged and elderly people, improve immunologic function, health invigorating all benefits.
Detailed description of the invention
For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1:
The present embodiment strengthens the Ganoderma spore powder compound product of antitumor curative effect, is made up: Ganoderma spore powder with cellular wall broken 100 parts, Herba Dendrobii 85 parts, Ganoderma 62 parts, Fructus Lycii 48 parts, powder of Fructus Corni 70 parts, the Radix Astragali 28 parts, Cordyceps militaris (L.) Link. 14 parts, 30 parts, Radix Adenophorae (Radix Glehniae) powder, Radix Ophiopogonis powder 22 parts, lentinan 23 parts, taxol 7 parts, Radix Rhodiolae 9 parts, 7 parts, moringa seeds powder of the raw material of following weight portion.
Preparation method, comprises the following steps:
S1, select operable Herba Dendrobii branch, clean, drain, cutting, drier after freezing, then use pulverizer superfine grinding, take the Herba Dendrobii lyophilized powder produced according to weight portion, for subsequent use;
S2, choose the measured raw material of clean and dried matter again, take raw material according to weight portion, for subsequent use;
S3, by ready raw material mixing in step S1 and S2, add water 80-110 DEG C of 5-10 times amount by the weight of mixture and decoct 1-3h, decocts 1-3 time, merging decoction liquor, filtration, obtains filtrate;
S4, the filtrate obtained by step S2, be concentrated into paste, obtain thick paste, by thick paste, the 2-5 amount doubly of weight adds the ethanol water that volume fraction is 55-65%, stirs 10-30min, leaves standstill, get supernatant, decompression recycling ethanol, obtains extractum, for subsequent use, extractum is when 55-65 DEG C, and relative density is 1.15-1.20;
S5, the extractum obtained by step S3 are granulated, 60 DEG C of drying under reduced pressure 2-4 hour, and granulate, cross 20 mesh sieves, filled capsules, obtains capsule.
Embodiment 2:
The present embodiment strengthens the Ganoderma spore powder compound product of antitumor curative effect, is made up: Ganoderma spore powder with cellular wall broken 110 parts, Herba Dendrobii 90 parts, Ganoderma 65 parts, Fructus Lycii 50 parts, powder of Fructus Corni 75 parts, the Radix Astragali 31 parts, Cordyceps militaris (L.) Link. 17 parts, 36 parts, Radix Adenophorae (Radix Glehniae) powder, Radix Ophiopogonis powder 25 parts, lentinan 25 parts, taxol 8 parts, Radix Rhodiolae 13 parts, 10 parts, moringa seeds powder of the raw material of following weight portion.
Preparation method, comprises the following steps:
S1, select operable Herba Dendrobii branch, clean, drain, cutting, drier after freezing, then use pulverizer superfine grinding, take the Herba Dendrobii lyophilized powder produced according to weight portion, for subsequent use;
S2, choose the measured raw material of clean and dried matter again, take raw material according to weight portion, for subsequent use;
S3, by ready raw material mixing in step S1 and S2, add water 80-110 DEG C of 5-10 times amount by the weight of mixture and decoct 1-3h, decocts 1-3 time, merging decoction liquor, filtration, obtains filtrate;
S4, the filtrate obtained by step S2, be concentrated into paste, obtain thick paste, and the volume fraction adding 4 times amount by the weight of thick paste is the ethanol water of 65%, stir and leave standstill, get supernatant, decompression recycling ethanol, obtain extractum, for subsequent use, described extractum is when 55-65 DEG C, and relative density is 1.15-1.20;
S5, the extractum obtained by step S3 are granulated, and dry 1-2 hour at 55-65 DEG C, then carries out tabletting, obtain tablet on tablet machine.
Embodiment 3:
The present embodiment strengthens the Ganoderma spore powder compound product of antitumor curative effect, is made up: Ganoderma spore powder with cellular wall broken 120 parts, Herba Dendrobii 95 parts, Ganoderma 70 parts, Fructus Lycii 55 parts, powder of Fructus Corni 80 parts, the Radix Astragali 34 parts, Cordyceps militaris (L.) Link. 20 parts, 40 parts, Radix Adenophorae (Radix Glehniae) powder, Radix Ophiopogonis powder 30 parts, lentinan 27 parts, taxol 9 parts, Radix Rhodiolae 17 parts, 14 parts, moringa seeds powder of the raw material of following weight portion.
Preparation method, comprises the following steps:
S1, select operable Herba Dendrobii branch, clean, drain, cutting, drier after freezing, then use pulverizer superfine grinding, take the Herba Dendrobii lyophilized powder produced according to weight portion, for subsequent use;
S2, choose the measured raw material of clean and dried matter again, take raw material according to weight portion, for subsequent use;
S3, by ready raw material mixing in step S1 and S2, add water 80-110 DEG C of 5-10 times amount by the weight of mixture and decoct 1-3h, decocts 1-3 time, merging decoction liquor, filtration, obtains filtrate;
S4, the filtrate obtained by step S2, be concentrated into paste, obtain thick paste, and the volume fraction adding 2.5 times amount by the weight of thick paste is the ethanol water of 55%, stir and leave standstill, get supernatant, decompression recycling ethanol, obtain extractum, for subsequent use, described extractum is when 55-65 DEG C, and relative density is 1.15-1.20;
S5, the extractum spraying dry obtained by step S3, obtain fine powder, then after being dissolved in water by fine powder, add 2% sucrose, then add water to 500ml, mixing, and filter, fill, sterilizing, makes oral liquid.
Embodiment 4:
The present embodiment strengthens the Ganoderma spore powder compound product of antitumor curative effect, is made up: Ganoderma spore powder with cellular wall broken 80 parts, Herba Dendrobii 80 parts, Ganoderma 60 parts, Fructus Lycii 45 parts, powder of Fructus Corni 65 parts, the Radix Astragali 24 parts, Cordyceps militaris (L.) Link. 10 parts, 30 parts, Radix Adenophorae (Radix Glehniae) powder, Radix Ophiopogonis powder 20 parts, lentinan 20 parts, taxol 5 parts, Radix Rhodiolae 6 parts, 5 parts, moringa seeds powder of the raw material of following weight portion.
According to the present embodiment parts by weight of raw materials, preparation method is with embodiment 1.
Embodiment 5:
The present embodiment strengthens the Ganoderma spore powder compound product of antitumor curative effect, is made up: Ganoderma spore powder with cellular wall broken 130 parts, Herba Dendrobii 100 parts, Ganoderma 70 parts, Fructus Lycii 55 parts, powder of Fructus Corni 85 parts, the Radix Astragali 38 parts, Cordyceps militaris (L.) Link. 24 parts, 40 parts, Radix Adenophorae (Radix Glehniae) powder, Radix Ophiopogonis powder 30 parts, lentinan 30 parts, taxol 10 parts, Radix Rhodiolae 20 parts, 14 parts, moringa seeds powder of the raw material of following weight portion.
According to the present embodiment parts by weight of raw materials, preparation method is with embodiment 1.
Embodiment 6:
The present embodiment strengthens the Ganoderma spore powder compound product of antitumor curative effect, is made up: Ganoderma spore powder with cellular wall broken 9 parts, Herba Dendrobii 92 parts, Ganoderma 68 parts, Fructus Lycii 46 parts, powder of Fructus Corni 72 parts, the Radix Astragali 31 parts, Cordyceps militaris (L.) Link. 15 parts, 33 parts, Radix Adenophorae (Radix Glehniae) powder, Radix Ophiopogonis powder 26 parts, lentinan 24 parts, taxol 7 parts, Radix Rhodiolae 18 parts, 11 parts, moringa seeds powder of the raw material of following weight portion.
According to the present embodiment parts by weight of raw materials, preparation method is with embodiment 1.
It should be noted that, in this article, the such as relational terms of first and second grades and so on is only used for an entity or operation to separate with another entity or operating space, and not necessarily requires or imply the relation that there is any this reality between these entities or operation or sequentially.And, term " comprises ", " comprising " or its any other variant are intended to contain comprising of nonexcludability, thus make to comprise the process of a series of key element, method, article or equipment and not only comprise those key elements, but also comprise other key elements clearly do not listed, or also comprise by the intrinsic key element of this process, method, article or equipment.When not more restrictions, the key element limited by statement " comprising ... ", and be not precluded within process, method, article or the equipment comprising described key element and also there is other identical element.
Above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit, although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (6)
1. one kind strengthens the Ganoderma spore powder compound product of antitumor curative effect, it is characterized in that, be made up of the raw material of following weight portion: Ganoderma spore powder with cellular wall broken 80-130 part, Herba Dendrobii 80-100 part, Ganoderma 60-70 part, Fructus Lycii 45-55 part, powder of Fructus Corni 65-85 part, Radix Astragali 24-38 part, Cordyceps militaris (L.) Link. 10-24 part, Radix Adenophorae (Radix Glehniae) powder 30-40 part, Radix Ophiopogonis powder 20-30 part, lentinan 20-30 part, taxol 5-10 part, Radix Rhodiolae 6-20 part, moringa seeds powder 5-14 part.
2. the Ganoderma spore powder compound product of enhancing antitumor curative effect according to claim 1, it is characterized in that, be made up of the raw material of following weight portion: Ganoderma spore powder with cellular wall broken 100-120 part, Herba Dendrobii 85-95 part, Ganoderma 62-70 part, Fructus Lycii 48-55 part, powder of Fructus Corni 70-80 part, Radix Astragali 28-34 part, Cordyceps militaris (L.) Link. 14-20 part, Radix Adenophorae (Radix Glehniae) powder 30-40 part, Radix Ophiopogonis powder 22-30 part, lentinan 23-27 part, taxol 7-9 part, Radix Rhodiolae 9-17 part, moringa seeds powder 7-14 part.
3. the Ganoderma spore powder compound product of enhancing antitumor curative effect according to claim 1, it is characterized in that, be made up of the raw material of following weight portion: Ganoderma spore powder with cellular wall broken 110 parts, Herba Dendrobii 90 parts, Ganoderma 65 parts, Fructus Lycii 50 parts, powder of Fructus Corni 75 parts, the Radix Astragali 31 parts, Cordyceps militaris (L.) Link. 17 parts, 36 parts, Radix Adenophorae (Radix Glehniae) powder, Radix Ophiopogonis powder 25 parts, lentinan 25 parts, taxol 8 parts, Radix Rhodiolae 13 parts, 10 parts, moringa seeds powder.
4. the Ganoderma spore powder compound product of enhancing antitumor curative effect according to claim 1, is characterized in that, described compound product is capsule, tablet or oral liquid.
5. a preparation method for the Ganoderma spore powder compound product of the enhancing antitumor curative effect as described in as arbitrary in claim 1-4, is characterized in that, comprise the following steps:
S1, select operable Herba Dendrobii branch, clean, drain, cutting, drier after freezing, then use pulverizer superfine grinding, take the Herba Dendrobii lyophilized powder produced according to weight portion, for subsequent use;
S2, choose the measured raw material of clean and dried matter again, take raw material according to weight portion, for subsequent use;
S3, by ready raw material mixing in step S1 and S2, add water 80-110 DEG C of 5-10 times amount by the weight of mixture and decoct 1-3h, decocts 1-3 time, merging decoction liquor, filtration, obtains filtrate;
S4, the filtrate obtained by step S2, be concentrated into paste, obtain thick paste, and by thick paste, the 2-5 amount doubly of weight adds the ethanol water that volume fraction is 55-65%, stirs 10-30min, leaves standstill, get supernatant, decompression recycling ethanol, obtain extractum, for subsequent use;
S5, the extractum obtained by step S3 are granulated, 60 DEG C of drying under reduced pressure 2-4 hour, granulate, and cross 20 mesh sieves, filled capsules, obtains capsule; Or the extractum obtained by step S3 is granulated, and dry 1-2 hour at 55-65 DEG C, then carries out tabletting, obtain tablet on tablet machine; Or the extractum spraying dry obtained by step S3, obtains fine powder, then after being dissolved in water by fine powder, add 2% sucrose, then add water to 500ml, mixing, filter, fill, sterilizing.
6. the preparation method of the Ganoderma spore powder compound product of enhancing antitumor curative effect according to claim 5, is characterized in that, decocting temperature described in step S3 is 105 DEG C, and decocting time is 2h.
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Application publication date: 20160127 |