CN104381991A - Ganoderma lucidum sporoderm-broken spore powder capsule and preparation method thereof - Google Patents
Ganoderma lucidum sporoderm-broken spore powder capsule and preparation method thereof Download PDFInfo
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Abstract
Description
技术领域 technical field
本发明涉及一种胶囊制剂的保健品,特别涉及一种破壁灵芝孢子粉灵芝胶囊及其制备方法。 The present invention relates to a capsule preparation health care product, in particular to a Ganoderma lucidum capsule with broken wall Ganoderma spore powder and a preparation method thereof.
背景技术 Background technique
随着社会竞争日趋激烈,人们的生活与工作压力越来越大;同时,环境污染也越来越严重。人们在内在压力和外在环境的双重作用下,人们的体质开始变差,经常出现感冒、消化不良、失眠、高血压、高血脂等毛病。免疫力下降、亚健康等状况越来越常见,人们需要合适且方便的营养保健品来改善这一状况。 With the increasingly fierce social competition, people's life and work pressure is increasing; at the same time, environmental pollution is becoming more and more serious. Under the dual effects of internal pressure and external environment, people's physical fitness begins to deteriorate, and they often suffer from colds, indigestion, insomnia, high blood pressure, high blood fat and other problems. Conditions such as decreased immunity and sub-health are becoming more and more common, and people need suitable and convenient nutritional health products to improve this condition.
灵芝又称灵芝草、神芝、芝草、仙草、瑞草,是多孔菌科植物赤芝或紫芝的全株。以紫灵芝药效为最好,灵芝原产于亚洲东部,中国分布最广的在江西,灵芝作为拥有数千年药用历史的中国传统珍贵药材,具备很高的药用价值,经过科研机构数十年的现代药理学研究证实,灵芝对于增强人体免疫力,调节血糖,控制血压,辅助肿瘤放化疗,保肝护肝,促进睡眠等方面均具有显著疗效。 Ganoderma lucidum, also known as Ganoderma lucidum, Shenzhi, Zhicao, Xiancao, and Ruicao, is the whole plant of Chizhi or Zizhi, a plant of Polyporaceae. Purple Ganoderma lucidum is the most effective. Ganoderma lucidum is native to eastern Asia, and the most widely distributed in China is in Jiangxi. As a traditional Chinese medicinal material with thousands of years of medicinal history, Ganoderma lucidum has high medicinal value. Decades of modern pharmacological research have confirmed that Ganoderma lucidum has significant effects on enhancing human immunity, regulating blood sugar, controlling blood pressure, assisting tumor radiotherapy and chemotherapy, protecting the liver and promoting sleep.
灵芝孢子粉是灵芝在生长成熟期,从灵芝菌褶中弹射出来的极其微小的卵形生殖细胞即灵芝的种子,它凝聚了灵芝的精华,具有灵芝的全部遗传物质和保健作用,平均每100 公斤灵芝才能采集到1 公斤纯正的孢子粉。据测定灵芝孢子粉含有灵芝多糖、灵芝多肽、三萜类、氨基酸、蛋白质、脂肪酸、微量元素等活性物质,特别是脂溶性物质可高达20%,其中主要为不饱和脂肪酸。灵芝孢子的大小只有5-10 个微米,在显微镜下可见到卵圆形状的物体,是个活体生物体,外被坚硬的几丁质纤维素(孢子壁)所包围,这层孢子壁对外界的机械、物理、化学因素的损害具有良好的保护作用,很难被破坏,因此现有的灵芝孢子粉存在着直接食用不易被人体充分消化吸收的问题。 Ganoderma lucidum spore powder is the extremely tiny oval germ cells ejected from the gills of Ganoderma lucidum, that is, the seeds of Ganoderma lucidum during the growth and maturity stage. It takes 1 kg of Ganoderma lucidum to collect 1 kg of pure spore powder. It is determined that Ganoderma lucidum spore powder contains active substances such as Ganoderma lucidum polysaccharides, Ganoderma lucidum polypeptides, triterpenoids, amino acids, proteins, fatty acids, trace elements, etc., especially fat-soluble substances can be as high as 20%, of which mainly unsaturated fatty acids. The size of Ganoderma lucidum spores is only 5-10 microns, and an oval-shaped object can be seen under a microscope. It is a living organism and is surrounded by hard chitin cellulose (spore wall). The damage of mechanical, physical and chemical factors has a good protective effect and is difficult to be destroyed. Therefore, the existing Ganoderma lucidum spore powder has the problem that it is difficult to be fully digested and absorbed by the human body when it is directly eaten.
灵芝自古就是保健佳品,由于新鲜灵芝保藏不易,而且未经加工的灵芝不易被人体吸收,所以目前市场上有很多灵芝的加工品,而要将灵芝的效果发挥好,需要科学的配方和科学的工艺才能实现。 Ganoderma lucidum has been a good health product since ancient times. Because it is not easy to preserve fresh Ganoderma lucidum, and the unprocessed Ganoderma lucidum is not easy to be absorbed by the human body, there are many processed products of Ganoderma lucidum on the market. To exert the effect of Ganoderma lucidum well, scientific formulas and scientific methods are required. technology can be realized.
发明内容 Contents of the invention
本发明的目的是提供一种能提高人体免疫力并且吸收效果好的破壁灵芝孢子粉灵芝胶囊及其制备方法。 The object of the present invention is to provide a ganoderma lucidum capsule with broken wall ganoderma spore powder and a preparation method thereof which can improve human immunity and has good absorption effect.
为实现上述目的,本发明提供了一种破壁灵芝孢子粉灵芝胶囊,包括原料和辅料,所述原料包括以下重量份的组分灵芝提取物65-75份,破壁灵芝孢子粉145-155份,所述辅料包括以下重量份的组分糊精170-185份,二氧化硅1.5-2.5份。 In order to achieve the above object, the present invention provides a Ganoderma lucidum capsule of broken wall ganoderma spore powder, including raw materials and auxiliary materials. The auxiliary material includes the following components by weight: 170-185 parts of dextrin and 1.5-2.5 parts of silicon dioxide.
作为本发明的优选技术方案,所述原料包括以下重量份的组分灵芝提取物70份,破壁灵芝孢子粉150份,所述辅料包括以下重量份的组分糊精178份,二氧化硅2份。 As a preferred technical solution of the present invention, the raw material includes 70 parts by weight of the component Ganoderma lucidum extract, 150 parts of the broken Ganoderma lucidum spore powder, and the auxiliary material includes 178 parts by weight of the component dextrin, silicon dioxide 2 servings.
其中,所述灵芝提取物的粗多糖含量为10%,所述破壁灵芝孢子粉的粗多糖含量为2%。 Wherein, the crude polysaccharide content of the Ganoderma lucidum extract is 10%, and the crude polysaccharide content of the broken Ganoderma lucidum spore powder is 2%.
本发明还提供了一种破壁灵芝孢子粉灵芝胶囊的制备方法,包括以下步骤: The present invention also provides a preparation method of Ganoderma Lucidum Capsules, comprising the following steps:
1)领取原料:按比例领取符合标准、经检验合格的各类原料,包括灵芝提取物、已灭菌的破壁灵芝孢子粉、糊精和二氧化硅; 1) Receive raw materials: Proportionally receive all kinds of raw materials that meet the standards and have passed the inspection, including Ganoderma lucidum extract, sterilized broken-walled Ganoderma lucidum spore powder, dextrin and silicon dioxide;
2)送料:各原辅料去掉外包装后,内包装通过物流通道进入三十万级洁净区; 2) Feeding: After removing the outer packaging of each raw and auxiliary material, the inner packaging enters the 300,000-class clean area through the logistics channel;
3)粉碎、过筛、称量:将灵芝提取物、破壁灵芝孢子粉、糊精分别粉碎,然后分别过80目筛,得细粉,按配方比例称量灵芝提取物细粉、破壁灵芝孢子粉细粉、糊精细粉和二氧化硅,备用; 3) Crush, sieve, weigh: Ganoderma lucidum extract, broken-walled ganoderma spore powder, and dextrin are respectively pulverized, and then passed through 80-mesh sieves to obtain fine powder, and weighed according to the formula ratio. Ganoderma lucidum spore powder fine powder, paste fine powder and silicon dioxide, set aside;
4)混合:将灵芝提取物细粉、破壁灵芝孢子粉细粉和糊精细粉充分混合30min,得混合粉,将混合粉与二氧化硅混合10min,得混合物; 4) Mixing: fully mix the fine powder of Ganoderma lucidum extract, the fine powder of Ganoderma lucidum spore powder and the fine powder of paste fine powder for 30 minutes to obtain a mixed powder, and mix the mixed powder with silicon dioxide for 10 minutes to obtain a mixture;
5)灌装胶囊:将混合物灌装胶囊,得胶囊; 5) Filling capsules: filling the mixture into capsules to obtain capsules;
6)抛光:除去胶囊表面的粉末; 6) Polishing: remove the powder on the capsule surface;
7)挑选:挑选去除不合格胶囊; 7) Selection: selection and removal of unqualified capsules;
8)内包装:60粒/瓶; 8) Inner packing: 60 capsules/bottle;
9)外包装; 9) Outer packaging;
10)检验; 10) Inspection;
11)入库。 11) Storage.
本发明具有增强免疫力的保健功能,适合免疫力低下者,具有调节人体免疫力功能、抑制肿瘤、延缓衰老等保健作用,并且各种成分相辅相成,易于吸收。其中芝提取物的粗多糖含量为10%,规格是10:1,破壁灵芝孢子粉的粗多糖含量为2%,粗多糖能促进双歧杆菌的增殖,抑制病原菌,防止便秘、腹胀,促进消化,调节胃肠功能,增强免疫功能等。本发明的破壁灵芝孢子粉灵芝胶囊服用方法及服用量为口服,每日2次,每次3粒。 The invention has the health-care function of enhancing immunity, is suitable for people with low immunity, has health-care functions such as regulating human immunity, suppressing tumors, delaying aging, and the like, and various components complement each other and are easy to absorb. Among them, the content of crude polysaccharide in Ganoderma lucidum extract is 10%, and the specification is 10:1. The content of crude polysaccharide in broken Ganoderma lucidum spore powder is 2%. Crude polysaccharide can promote the proliferation of bifidobacteria, inhibit pathogenic bacteria, prevent constipation and abdominal distension, and promote Digestion, regulating gastrointestinal function, enhancing immune function, etc. The taking method and dosage of the Ganoderma lucidum spore powder Ganoderma lucidum capsule of the present invention is oral administration, 2 times a day, 3 capsules each time.
本发明采用了科学的制备工序和参数,营养易于吸收,而且方便携带。本发明具有改善肠道功能、调节肠道菌群作用,在胃内溶解后破壁灵芝孢子粉中的部分纤维素能改善肠道功能,清理肠道,如促进肠道蠕动,排除代谢废物,同时本发明还具有调节免疫力、调节血压、血脂、血糖功能。 The present invention adopts scientific preparation procedures and parameters, the nutrition is easy to absorb, and it is convenient to carry. The invention has the functions of improving intestinal function and regulating intestinal flora. After being dissolved in the stomach, part of the cellulose in the broken Ganoderma lucidum spore powder can improve intestinal function and clean the intestinal tract, such as promoting intestinal peristalsis and eliminating metabolic waste. Simultaneously, the present invention also has the functions of regulating immunity, blood pressure, blood fat and blood sugar.
具体实施方式 Detailed ways
下面详细说明本发明的优选技术方案。 The preferred technical solution of the present invention will be described in detail below.
实施例一 Embodiment 1
配方:所述原料包括灵芝提取物67g,破壁灵芝孢子粉153g,所述辅料包括糊精172g,二氧化硅2.2g。 Formula: The raw materials include 67g of Ganoderma lucidum extract, 153g of broken Ganoderma lucidum spore powder, and the excipients include 172g of dextrin and 2.2g of silicon dioxide.
以上各原辅料共制成1000粒(约0.4g/粒)。 A total of 1,000 capsules (about 0.4g/capsule) of the above raw and auxiliary materials are made.
实施例二 Example 2
配方:所述原料包括灵芝提取物73g,破壁灵芝孢子粉147g,所述辅料包括糊精182g,二氧化硅1.8g。 Formula: The raw materials include 73g of Ganoderma lucidum extract, 147g of broken Ganoderma lucidum spore powder, and the excipients include 182g of dextrin and 1.8g of silicon dioxide.
以上各原辅料共制成1000粒(约0.4g/粒)。 A total of 1,000 capsules (about 0.4g/capsule) of the above raw and auxiliary materials are made.
实施例三 Embodiment Three
配方:所述原料包括灵芝提取物70g,破壁灵芝孢子粉150g,所述辅料包括糊精178g,二氧化硅2g。 Formula: The raw materials include 70g of Ganoderma lucidum extract, 150g of broken Ganoderma lucidum spore powder, and the auxiliary materials include 178g of dextrin and 2g of silicon dioxide.
以上各原辅料共制成1000粒(约0.4g/粒)。 A total of 1,000 capsules (about 0.4g/capsule) of the above raw and auxiliary materials are made.
一种破壁灵芝孢子粉灵芝胶囊的制备方法,包括以下步骤: A preparation method of Ganoderma lucidum spore powder Ganoderma lucidum capsule, comprising the following steps:
1)领取原料:按比例领取符合标准、经检验合格的各类原料,包括灵芝提取物、已灭菌的破壁灵芝孢子粉、糊精和二氧化硅; 1) Receive raw materials: Proportionally receive all kinds of raw materials that meet the standards and have passed the inspection, including Ganoderma lucidum extract, sterilized broken-walled Ganoderma lucidum spore powder, dextrin and silicon dioxide;
2)送料:各原辅料去掉外包装后,内包装通过物流通道进入三十万级洁净区; 2) Feeding: After removing the outer packaging of each raw and auxiliary material, the inner packaging enters the 300,000-class clean area through the logistics channel;
3)粉碎、过筛、称量:将灵芝提取物、破壁灵芝孢子粉、糊精分别粉碎,然后分别过80目筛,得细粉,按配方比例称量灵芝提取物细粉、破壁灵芝孢子粉细粉、糊精细粉和二氧化硅,备用; 3) Crush, sieve, weigh: Ganoderma lucidum extract, broken-walled ganoderma spore powder, and dextrin are respectively pulverized, and then passed through 80-mesh sieves to obtain fine powder, and weighed according to the formula ratio. Ganoderma lucidum spore powder fine powder, paste fine powder and silicon dioxide, set aside;
4)混合:将灵芝提取物细粉、破壁灵芝孢子粉细粉和糊精细粉充分混合30min,得混合粉,将混合粉与二氧化硅混合10min,得混合物; 4) Mixing: fully mix the fine powder of Ganoderma lucidum extract, the fine powder of Ganoderma lucidum spore powder and the fine powder of paste fine powder for 30 minutes to obtain a mixed powder, and mix the mixed powder with silicon dioxide for 10 minutes to obtain a mixture;
5)灌装胶囊:将混合物灌装胶囊,得胶囊; 5) Filling capsules: filling the mixture into capsules to obtain capsules;
6)抛光:除去胶囊表面的粉末; 6) Polishing: remove the powder on the capsule surface;
7)挑选:挑选去除不合格胶囊; 7) Selection: selection and removal of unqualified capsules;
8)内包装:60粒/瓶; 8) Inner packing: 60 capsules/bottle;
9)外包装; 9) Outer packaging;
10)检验; 10) Inspection;
11)入库。 11) Storage.
本发明具有增强免疫力的保健功能,适合免疫力低下者,具有调节人体免疫力功能、抑制肿瘤、延缓衰老等保健作用,并且各种成分相辅相成,易于吸收。其中芝提取物的粗多糖含量为10%,规格是10:1,破壁灵芝孢子粉的粗多糖含量为2%,粗多糖能促进双歧杆菌的增殖,抑制病原菌,防止便秘、腹胀,促进消化,调节胃肠功能,增强免疫功能等。本发明的破壁灵芝孢子粉灵芝胶囊服用方法及服用量为口服,每日2次,每次3粒。 The present invention has the health care function of enhancing immunity, is suitable for people with low immunity, and has health care functions such as regulating human immunity, suppressing tumors, delaying aging, etc., and various components complement each other and are easy to absorb. Among them, the content of crude polysaccharide in Ganoderma lucidum extract is 10%, and the specification is 10:1. The content of crude polysaccharide in broken Ganoderma lucidum spore powder is 2%. Crude polysaccharide can promote the proliferation of bifidobacteria, inhibit pathogenic bacteria, prevent constipation and abdominal distension, and promote Digestion, regulating gastrointestinal function, enhancing immune function, etc. The taking method and dosage of the Ganoderma lucidum spore powder Ganoderma lucidum capsule of the present invention is oral administration, 2 times a day, 3 capsules each time.
灵芝提取物是适时采收成熟的新鲜子实体,烘干后采用热水浸提(或酒精提取)、真空浓缩、喷雾干燥等工艺,得到的灵芝浸膏粉,是灵芝粉高倍浓缩而成的灵芝精华。 Ganoderma lucidum extract is harvested and ripened fresh fruiting bodies in good time. After drying, hot water extraction (or alcohol extraction), vacuum concentration, spray drying and other processes are used to obtain Ganoderma lucidum extract powder, which is highly concentrated from Ganoderma lucidum powder. Ganoderma lucidum essence.
灵芝多糖类化合物是灵芝所含重要生理活性成分,深受医药科技工作者的重视,灵芝多糖可抑制肿瘤细胞的无限、快速分裂能力,目前,灵芝多糖已被用作治疗肿瘤的药物之一。现已证明:灵芝多糖还具有提高机体免疫力,提高机体耐缺氧能力,降血糖作用、降血脂作用、抗放射和抗衰老作用。灵芝多糖是从灵芝中提取的有效成分,其功效显著,保健价值极高,可做为灵芝多糖胶囊、片剂、冲剂等各类保健品、功能性食品、饮料的原料。 Ganoderma lucidum polysaccharides are important physiologically active ingredients contained in Ganoderma lucidum, which are highly valued by medical science and technology workers. Ganoderma lucidum polysaccharides can inhibit the unlimited and rapid division of tumor cells. At present, Ganoderma lucidum polysaccharides have been used as one of the drugs for treating tumors . It has been proved that Ganoderma lucidum polysaccharide can also improve the body's immunity, improve the body's ability to withstand hypoxia, lower blood sugar, lower blood fat, anti-radiation and anti-aging effects. Ganoderma lucidum polysaccharide is an active ingredient extracted from Ganoderma lucidum. It has remarkable efficacy and high health value. It can be used as the raw material of various health products, functional foods, and beverages such as Ganoderma lucidum polysaccharide capsules, tablets, and granules.
灵芝提取物可调节免疫系统的众多组成成分,其中部分被认为具有明显的抗肿瘤特性。在实验室条件下,灵芝提取物中多种灵芝酸和多糖显示可作为活性抗HIV物质,,并表现出在保守剂量下降低病毒复制达50%的能力,和其它东方药草混合后,灵芝现在被用于对艾滋病相关综合症,AIDS的治疗,并单独或+与其它药材混用治疗慢性疲劳症候群。 Ganoderma lucidum extracts modulate numerous components of the immune system, some of which are thought to have significant antitumor properties. Under laboratory conditions, a variety of ganoderma acids and polysaccharides in Ganoderma lucidum extracts have been shown to act as active anti-HIV substances, and have shown the ability to reduce virus replication by 50% at conservative doses. After mixing with other oriental herbs, Ganoderma lucidum is now It is used for the treatment of AIDS-related syndromes, AIDS, and chronic fatigue syndrome alone or in combination with other medicinal materials.
破壁灵芝孢子粉的主要成分为灵芝多糖、三萜类的灵芝酸和天然有机锗。 The main components of broken ganoderma lucidum spore powder are ganoderma polysaccharide, triterpenoid ganoderma acid and natural organic germanium.
其中灵芝多糖可增强免疫系统的机能,预防和治疗肿瘤及癌症;降低血压,预防心血管疫病的产生;刺激胰岛素的分泌,降低血糖浓度;加速血液微循环,提高血液供氧能力,降低机体静止状态下的无效耗氧量,消除体内自由基,提高机体细胞膜的封闭度,抗放射,提高肝脏、骨髓、血液合成 DNA,RNA,蛋白质的能力,延长 寿命等。灵芝的多种药理活性大多和灵芝多糖有关。 Among them, Ganoderma lucidum polysaccharide can enhance the function of the immune system, prevent and treat tumors and cancers; lower blood pressure, prevent the occurrence of cardiovascular diseases; stimulate insulin secretion, reduce blood sugar concentration; accelerate blood microcirculation, improve blood oxygen supply capacity, and reduce body static Ineffective oxygen consumption in the state, eliminate free radicals in the body, improve the sealing degree of the body's cell membrane, resist radiation, improve the ability of the liver, bone marrow, and blood to synthesize DNA, RNA, and protein, and prolong life. The various pharmacological activities of Ganoderma lucidum are mostly related to Ganoderma lucidum polysaccharides.
三萜类的灵芝酸可改善微循环,降低胆固醇,避免血管硬化;强化肝脏、脾脏及肠胃功能、健全消化器官的运作。 Ganoderma acid of triterpenoids can improve microcirculation, lower cholesterol, prevent arteriosclerosis; strengthen liver, spleen and gastrointestinal function, and improve the functioning of digestive organs.
天然有机锗能增强人体血液供养量,促进血液新陈代谢,消除体内自由基,防止细胞老化;可以从癌细胞中夺取电子,使其电位下降,从而抑制癌细胞恶化和扩散。 Natural organic germanium can enhance the blood supply of the human body, promote blood metabolism, eliminate free radicals in the body, and prevent cell aging; it can capture electrons from cancer cells to lower their potential, thereby inhibiting the deterioration and spread of cancer cells.
糊精中所含的麦芽糊精是由淀粉经低度水解、净化、喷雾干燥制成,不含游离淀粉的淀粉衍生物。英文简称为MD. 具有粘性大、增稠性强、溶解性好、速溶性佳、载体性好、发酵小、吸潮性低、无异味、甜度低,人体易于消化吸收、低热、低脂肪等特点,是食品工业中最理想的基础原料之一,可作为药用糖的增稠剂和稳定剂,也可作为片剂或冲剂的赋形剂和填充剂。 The maltodextrin contained in the dextrin is a starch derivative that is made from starch through low-level hydrolysis, purification, and spray drying, and does not contain free starch. The English abbreviation is MD. It has high viscosity, strong thickening, good solubility, good instant solubility, good carrier, small fermentation, low moisture absorption, no peculiar smell, low sweetness, easy to digest and absorb by human body, low heat, low fat It is one of the most ideal basic raw materials in the food industry. It can be used as a thickener and stabilizer for medicinal sugar, as well as an excipient and filler for tablets or granules.
二氧化硅在食品工业中主要用于防止粉状食品聚集结块,以保持自由流动的一类食品添加剂或用于吸附液态的香料、油脂、维生素等,使之成为粉末状,如粉末油脂、固体香料和固体酒之类制品,例如可用于奶粉中。 Silica is mainly used in the food industry to prevent powdery food from agglomerating and agglomerating to maintain a free-flowing food additive or to absorb liquid spices, oils, vitamins, etc., making them into powder, such as powdered oil, Products such as solid spices and solid wine, for example, can be used in milk powder.
本发明采用了科学的制备工序和参数,营养易于吸收,而且方便携带。本发明具有改善肠道功能、调节肠道菌群作用,在胃内溶解后破壁灵芝孢子粉中的部分纤维素能改善肠道功能,清理肠道,如促进肠道蠕动,排除代谢废物,同时本发明还具有调节免疫力、调节血压、血脂、血糖功能。 The present invention adopts scientific preparation procedures and parameters, the nutrition is easy to absorb, and it is convenient to carry. The invention has the functions of improving intestinal function and regulating intestinal flora. After being dissolved in the stomach, part of the cellulose in the broken Ganoderma lucidum spore powder can improve intestinal function and clean the intestinal tract, such as promoting intestinal peristalsis and eliminating metabolic waste. Simultaneously, the present invention also has the functions of regulating immunity, blood pressure, blood fat and blood sugar.
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