CN105267676A - Nursing medicine liquid for treating burns and scalds and method for preparing nursing medicine liquid - Google Patents
Nursing medicine liquid for treating burns and scalds and method for preparing nursing medicine liquid Download PDFInfo
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- CN105267676A CN105267676A CN201510676064.8A CN201510676064A CN105267676A CN 105267676 A CN105267676 A CN 105267676A CN 201510676064 A CN201510676064 A CN 201510676064A CN 105267676 A CN105267676 A CN 105267676A
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Abstract
The invention discloses nursing medicine liquid for treating burns and scalds and a method for preparing the nursing medicine liquid. The nursing medicine liquid comprises Chinese and western medicine components including, by weight, 50-80 parts of white sesame oil, 4-10 parts of nacre mother of pearl, 2-12 parts of lithospermum purpurocaeruleum, 2-9 parts of borneol, 5-10 parts of common bletilla pseudobulb, 10-15 parts of sanguisorba officinalis, 20-25 parts of rhubarb, 5-15 parts of angelica sinensis, 8-12 parts of radix sophorae subprostratae, 10-15 parts of rhizoma paridis, 15-20 parts of fructus cnidii, 5-10 parts of fructus kochiae, 12-15 parts of honeysuckle, 5-10 parts of white cinnamon, 5-8 parts of peppermint, 5-10 parts of radix ampelopsis, 5-8 parts of panax notoginseng, 5-8 parts of pearl powder, 0.3-0.5 part of honey, 0.1-0.2 part of chlorhexidine acetate, 0.1-0.2 part of miconazole nitrate, 0.2-0.5 part of amoxicillin, 0.1-0.2 part of cefalexin and 0.2-0.5 part of furazolidone powder. The nursing medicine liquid and the method have the advantages that the nursing medicine liquid can be easily and feasibly prepared and is low in cost; the nursing medicine liquid has few side effects and is inexpensive, and the burns and scalds can be effectively treated by the aid of the nursing medicine liquid.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to a nursing liquid medicine for treating burns and scalds and a preparation method thereof.
Background
With the continuous expansion of social life, the knowledge of preventing burn and scald is not popularized in time, and the injured people rise year by year. About 5000-10000 people suffer from burns and scalds of various degrees in millions of people every year, the burns and scalds are mostly caused by high-temperature liquid in daily life, due to the massive popularization of various electric appliances and chemical articles, the burn and scald patients tend to rise, although the existing burn and scald treatment methods are many, the treatment effect is not ideal enough, most hospitals need to carry out isolation and skin grafting operations, the treatment period is long, the cost is high, the patients are easy to leave scars, some patients are caused with functional disorders, even the patients are infected with sepsis, and the risk of infectious death is caused.
Burn and scald are one and the complicated traumatic diseases caused by physical, chemical and radioactive factors. The four problems of severe pain, progressive necrosis, susceptibility to infection and scar exist in the treatment process. In the aspect of the deficiency of traditional Chinese medicine preparations or western medicines sold in the market at present in the process of treating burns and scalds, the defects of slow pain relieving, poor antibacterial effect and slow healing of the traditional Chinese medicine preparations are simply used, and most of the western medicines are easy to generate scars and the like.
Disclosure of Invention
In order to solve the problems, the invention provides the nursing liquid medicine for treating the burns and scalds and the preparation method thereof, the nursing liquid medicine combines Chinese and western medicines, has definite curative effect, can better improve clinical symptoms, has less side effect and low price, can treat the burns and scalds very well, does not need isolation and skin grafting operation in the using process, has short treatment period, is not easy to infect, does not leave scars or leaves few scars after healing, and the preparation method is simple and easy to implement and has low cost.
The technical scheme adopted by the invention for solving the technical problems is a nursing liquid medicine for treating burns and scalds, which comprises Chinese and western medicine components and is characterized in that the nursing liquid medicine consists of the following components in parts by weight: 50-80 parts of white sesame oil, 4-10 parts of mother-of-pearl, 2-12 parts of lithospermum, 2-9 parts of borneol, 5-10 parts of bletilla striata, 10-15 parts of sanguisorba officinalis, 20-25 parts of rheum officinale, 5-15 parts of angelica sinensis, 8-12 parts of sophora flavescens, 10-15 parts of typhonium giganteum, 15-20 parts of fructus cnidii, 5-10 parts of fructus kochiae, 12-15 parts of honeysuckle, 5-10 parts of cinnamomum cassia, 5-8 parts of mint, 5-10 parts of ampelopsis japonica, 5-8 parts of pseudo-ginseng, 5-8 parts of pearl powder, 0.3-0.5 part of honey, 0.1-0.2 part of chlorhexidine acetate, 0.1-0.2 part of miconazole nitrate, 0.2-0.5 part of amoxicillin, 0.1-0.2 part of cefalexin and 0.2-0.5 part of furazolidone powder.
Preferably, the nursing liquid medicine for treating burns and scalds comprises 60 parts of white sesame oil, 7 parts of mother-of-pearl, 7 parts of lithospermum, 5 parts of borneol, 8 parts of bletilla striata, 12 parts of sanguisorba officinalis, 22 parts of rheum officinale, 10 parts of angelica sinensis, 10 parts of sophora flavescens, 13 parts of typhonium giganteum, 18 parts of fructus cnidii, 7 parts of schiff s seeds, 14 parts of honeysuckle, 8 parts of cinnamomum cassia, 6 parts of mint, 7 parts of ampelopsis japonica, 7 parts of pseudo-ginseng, 6 parts of pearl powder, 0.4 part of honey, 0.1 part of chlorhexidine acetate, 0.2 part of miconazole nitrate, 0.4 part of amoxicillin, 0.2 part of cephalexin and 0.2 part of furazolidone powder.
In addition, the method for preparing the nursing liquid medicine for treating burns and scalds comprises the following steps:
1) weighing rinsed and dried or aired mother-of-pearl, lithospermum, bletilla striata, garden burnet and rheum officinale according to the weight parts, uniformly mixing, drying at the temperature of 55-65 ℃ for 30-40 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a sieve of 60-70 meshes; then drying for 20-30 minutes at 65-75 ℃, and uniformly stirring while drying; then sterilizing the mixture by using ultraviolet rays for 40-60 minutes, then putting the mixture into a superfine pulverizer to pulverize the mixture into fine powder which is sieved by a 200-220-mesh sieve, and uniformly mixing the fine powder; putting the sesame seeds into the white sesame oil, stirring and soaking for 2-3 days for later use;
2) weighing the angelica, the pseudo-ginseng, the typhonium giganteum and the fructus cnidii in parts by weight, uniformly mixing, drying at 55-65 ℃ for 15-20 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a sieve of 70-80 meshes; adding the weight of angelica, pseudo-ginseng, typhonium giganteum and fructus cnidii and 2.5 times of ethanol with the mass concentration of 70-75%, heating at 50-60 ℃, carrying out reflux extraction for 3 times, 1.5-2.5 hours each time, heating and concentrating the prepared ethanol extract at 55-65 ℃ until the concentration of the liquid medicine is 0.3g crude drug/ml, and drying into powder to obtain ethanol extraction dry powder for later use;
3) adding 5-6 times of water into the above components in parts by weight, heating and boiling for 2-3 hours, and extracting; adding 5 times of water, heating and boiling for 1-2 hours, and extracting; mixing the two extractive solutions, and filtering;
4) cleaning the mint and the ampelopsis japonica according to the parts by weight, chopping, pounding, adding 5-6 times of distilled water, uniformly stirring, and filtering to obtain a juice for later use;
5) chopping the sophora flavescens ait in parts by weight, steaming the chopped sophora flavescens ait in vinegar for 2 hours, adding borneol, pearl powder and honey in parts by weight, decocting the mixture for 2 to 5 hours, filtering the mixture by using a 500-mesh sieve, and extracting liquid medicine for later use;
6) adding the chlorhexidine acetate, miconazole nitrate, amoxicillin, cephalexin and furazolidone powder in parts by weight into a conventional regulating reagent, and regulating the pH value to a specified range for later use;
7) adding the reagent prepared in the step 6) into the product obtained in the step 1), stirring and mixing, and extracting liquid medicine for later use;
8) mixing and decocting the products obtained in the steps 2-5) and 7) for 2 times, wherein the first time lasts for 2.5-3.5 hours, and the second time lasts for 1.5-2.5 hours, filtering the mixture by using a 600-mesh sieve, and extracting liquid medicine for later use;
9) adding a pH adjusting reagent into the liquid medicine obtained in the step 8), adjusting the pH value to a specified range, bottling and sealing.
Preferably, 1 part of the raw materials is 10 g.
In any of the above embodiments, the PH is preferably 5.3 to 5.8.
In any of the above embodiments, it is preferred that the micronizer CF gas stream micronizer.
Wherein,
white sesame oil: detoxify and promote granulation, moisten skin and alleviate pain.
Mother-of-pearl: remove toxicity and promote tissue regeneration.
Lithospermum: clear heat and cool blood, promote eruption and remove toxicity, promote granulation and remove necrotic tissue.
Pseudo-ginseng: disperse blood stasis, stop bleeding, resolve swelling and alleviate pain. Can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic injury with swelling and pain.
Honeysuckle flower: clear heat and remove toxicity, and excel in clearing and removing blood toxicity, rash, macula, heat-toxin sores and abscess.
Mint: refreshing, dispelling pathogenic wind, relieving inflammation, relieving pain and itching.
Chinese angelica: has effects in nourishing blood, regulating menstruation, relieving pain, moistening dryness, smoothing intestine, resisting cancer, resisting aging, and enhancing immunity.
Corydalis saxicola bunting: clearing heat and eliminating dampness; dispel wind and kill parasites.
Typhonium giganteum: has the effects of clearing away heat and toxic materials, relieving swelling and pain, and cooling liver to arrest convulsion.
Fructus cnidii: clear heat and dry dampness, dispel wind and relieve itching.
A Kovu seed: strengthening waist and tonifying kidney; clearing heat and promoting diuresis; detoxification
Ampelopsis japonica: clear heat and remove toxicity, dissipate nodulation and alleviate pain, promote granulation and heal wound.
Pearl powder: detoxicating and generating organic sensation, and unhealing sores and ulcers. Has effects in whitening skin, controlling oil, removing acne, blackening hair, removing speckle, and promoting granulation.
Honey: has astringent, nourishing and healing promoting effects on wound surface.
The rhubarb, the sanguisorba and the borneol have the functions of clearing heat and removing toxicity, and pharmacological research proves that the rhubarb, the sanguisorba and the borneol can resist staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and the like; has synergistic effects in resisting inflammation and infection.
The traditional Chinese medicines such as the bletilla striata, the garden burnet root, the borneol and the like have the functions of astringing and promoting granulation, detoxifying and healing sore, removing slough, promoting granulation and relieving pain, can accelerate the growth speed of wound tissue epithelium, astringe and scab, and lead the wound to be sealed early with less chance of infection.
The chlorhexidine acetate can inhibit and kill pathogenic microorganisms such as Staphylococcus aureus, Pseudomonas aeruginosa, and Pseudomonas aeruginosa.
Miconazole nitrate: can inhibit most fungi from growing, and the Germination genus and the histoplasma genus are highly sensitive to the Germination genus and the histoplasma genus,cryptococcus neoformansGenus Candida, globulusSporeBacteria and the like are also sensitive to this herb.
Amoxicillin, cephalexin, furazolidone powder: has strong bactericidal effect.
The invention has the beneficial effects that:
1. the nursing liquid medicine for treating burns and scalds is convenient to apply, short in treatment course, quick in effect, free of toxic and side effects and free of drug dependence.
2. The nursing liquid medicine disclosed by the invention is combined in the Chinese and western directions, has the advantages of quick analgesic effect and strong healing capability, and shortens one third of the treatment course compared with the common treatment course; has good anti-inflammatory and antibacterial effects, and has inhibitory effect on common drug-resistant bacteria, especially on Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Candida albicans common in burn and scald.
3. The nursing liquid medicine for treating burns and scalds has the advantages of sufficient and guaranteed raw material component resources, high efficiency and obvious economic and social benefits.
4. The preparation method of the nursing liquid medicine for treating burns and scalds is simple and easy to implement, low in cost and convenient to popularize.
The traditional Chinese medicine raw materials are obtained through verification, recording and testing for years, although the efficacies of the raw materials are different, the selection of each traditional Chinese medicine is not random, the proportion of the raw materials obtained through the testing for years is not simple and superposed, because various traditional Chinese medicine raw materials possibly have various action relationships such as growing, reinforcing, mutual incompatibility and killing, and the like, the raw materials are correspondingly selected according to the principle, and the optimal proportion among the raw materials is determined, so the application has remarkable significance.
The safety toxicology test shows that the traditional Chinese medicine of the invention: LD50 is 8800mg/kg, safety toxicology evaluation is actual nontoxic grade, and no toxic and side effect.
Acute toxicity test
The experimental samples are prepared into suspensions, when the experimental samples are administrated through damaged skin in a dose which is 200 times of the clinical daily dose, the experimental samples have no influence on the behavioral activity, diet, fur luster and body weight of rats, and no toxic reaction of animals is found in the observation period. None of the animals died when observed for 15 days of dosing.
Long term toxicity test in animals
The samples are provided for rats for long-term administration for 2 months in a clinical daily dosage of 5 times, 15 times and 70 times, and have no obvious influence on the general conditions, blood routine, blood biochemical indexes, main organ coefficients, important organ tissue structures and the like of the rats. After stopping taking the medicine for 2 weeks, no obvious abnormality is found in all the indexes. The long-term toxicity test of continuous skin administration for 2 months of rats shows that the invention is safer, has no obvious toxic and side effect in the range of the tested dose,
allergy test
The high-dose group 1.87g crude drug/kg, the low-dose group 0.69g crude drug/kg and the excipient group do not cause the guinea pig to have anaphylactic reaction symptoms.
Irritation test
The high-dose group of 12.4 crude drug g/kg and the low-dose group of 7.7 crude drug g/kg of the invention can be applied to the back for a single time or multiple times, and do not generate any irritation reaction on the intact skin and damaged skin of animals, so the repeated skin application of the invention is safe.
Main pharmacodynamic experiments:
the invention carries out experiments of prescription removal, analgesia, inflammatory swelling, capillary permeability, skin wound healing, heat clearing, infection resistance and the like.
The invention can obviously increase the healing of the wound surface of scald, burn and skin cutting, and the healing rate of the wound surface is increased and even the healing effect is achieved along with the prolonging of time; can obviously reduce the content of IL-1, IL-6 and TNF-alpha in the serum of the rat; increasing the number of the granuloma tissue fibroblasts and the new capillaries after 7 days of skin cutting injury, and reducing the number of the granuloma tissue fibroblasts and the new capillaries after 14 days; meanwhile, the pain threshold of the mouse can be obviously improved, and the pain threshold reaches a peak 1.0-1.5 hours after administration; the invention can obviously reduce the times of mouse body twisting; the permeation quantity of the rat skin immersion liquid dye caused by scalding can be obviously reduced, and the permeability of capillary vessels is reduced; can obviously inhibit the mouse ear swelling caused by the dimethylbenzene; the swelling of the feet of the rat caused by 1 percent of carrageenan can be obviously inhibited in each time period of 1.5h, 3.5h, 5.5h and 7.5 h; the antipyretic effect is obvious after 60min, 120min and 180min after rat pyrogenicity; has good bacteriostatic and bactericidal effects on Escherichia coli, Staphylococcus aureus, copper green pseudomonas and Candida albicans.
The invention can inhibit the release of inflammatory mediators IL-1, IL-6 and TNF-alpha in the early stage of scald; the scald symptom is quickly relieved, and the wound healing and even healing effects are obviously promoted; has obvious anti-inflammatory, antibacterial, antipyretic and analgesic effects on inflammation and pain caused by scald.
Detailed Description
The present invention will be further described with reference to the following embodiments.
Example 1
A nursing liquid medicine for treating burns and scalds comprises Chinese and western medicine components, and the nursing liquid medicine comprises the following components in parts by weight: 600g of white sesame oil, 70g of mother-of-pearl, 70g of lithospermum, 50g of borneol, 80g of bletilla striata, 120g of sanguisorba officinalis, 220g of rheum officinale, 100g of angelica sinensis, 100g of sophora flavescens, 130g of typhonium giganteum, 180g of fructus cnidii, 70g of broom cypress fruit, 140g of honeysuckle flower, 80g of cinnamomum cassia, 60g of mint, 70g of ampelopsis japonica, 70g of panax notoginseng, 60g of pearl powder, 4g of honey, 1g of chlorhexidine acetate, 2g of miconazole nitrate, 4g of amoxicillin, 2g of cephalexin and 2g of furazolidone powder.
In addition, the method for preparing the nursing liquid medicine for treating burns and scalds comprises the following steps:
1) weighing rinsed and dried or aired mother-of-pearl, lithospermum, bletilla striata, garden burnet and rheum officinale according to the weight parts, uniformly mixing, drying at 55 ℃ for 40 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a 60-mesh sieve; then drying for 20 minutes at 75 ℃, and uniformly stirring while drying; sterilizing with ultraviolet rays for 60min, pulverizing into fine powder of 200 mesh, and mixing; soaking in oleum sesami under stirring for 3 days;
2) weighing the angelica, the pseudo-ginseng, the typhonium giganteum and the common cnidium fruit in parts by weight, uniformly mixing, drying at 55 ℃ for 20 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a 70-mesh sieve; adding the weight of the angelica, the pseudo-ginseng, the typhonium giganteum and the common cnidium fruit and 2.5 times of ethanol with the mass concentration of 75 percent, heating at 50 ℃, carrying out reflux extraction for 3 times, carrying out 2.5 hours each time, heating and concentrating the prepared ethanol extract at 55 ℃ until the concentration of the liquid medicine is 0.3g crude drug/ml, and drying into powder to obtain ethanol extraction dry powder for later use;
3) adding 6 times of water into the above-mentioned portions of broom cypress fruit, honeysuckle flower and cinnamon bark, heating and boiling for 2 hr, extracting; adding 5 times of water, heating and boiling for 2 hours, and extracting; mixing the two extractive solutions, and filtering;
4) cleaning the mint and the ampelopsis japonica according to the parts by weight, chopping, pounding, adding 5 times of distilled water, uniformly stirring, and filtering to obtain juice for later use;
5) chopping the sophora flavescens ait in parts by weight, steaming the chopped sophora flavescens ait in vinegar for 2 hours, adding borneol, pearl powder and honey in parts by weight, decocting the mixture for 5 hours, filtering the decoction by using a 500-mesh sieve, and extracting liquid medicine for later use;
6) adding the chlorhexidine acetate, miconazole nitrate, amoxicillin, cephalexin and furazolidone powder in parts by weight into a conventional regulating reagent, and regulating the pH value to a specified range for later use;
7) adding the reagent prepared in the step 6) into the product obtained in the step 1), stirring and mixing, and extracting liquid medicine for later use;
8) mixing and decocting the products obtained in the steps 2-5) and 7) for 2 times, wherein the first time is 2.5 hours, the second time is 2.5 hours, filtering the mixture by using a 600-mesh sieve, and extracting liquid medicine for later use;
9) adding a pH adjusting reagent into the liquid medicine obtained in the step 8), adjusting the pH value to a specified range, bottling and sealing.
Wherein the pH value is 5.3, and the superfine crusher is a CF airflow superfine crusher.
Example 2
A nursing liquid medicine for treating burns and scalds comprises Chinese and western medicine components, and the nursing liquid medicine comprises the following components in parts by weight: 500g of white sesame oil, 100g of mother-of-pearl, 20g of lithospermum, 90g of borneol, 50g of bletilla striata, 150g of sanguisorba officinalis, 200g of rheum officinale, 150g of angelica sinensis, 80g of sophora flavescens, 150g of typhonium giganteum, 150g of fructus cnidii, 100g of broom cypress fruit, 120g of honeysuckle flower, 100g of cinnamomum cassia, 50g of mint, 100g of ampelopsis japonica, 50g of panax notoginseng, 80g of pearl powder, 3g of honey, 2g of chlorhexidine acetate, 1g of miconazole nitrate, 5g of amoxicillin, 1g of cephalexin and 5g of furazolidone powder.
In addition, the method for preparing the nursing liquid medicine for treating burns and scalds comprises the following steps:
1) weighing rinsed and dried or aired mother-of-pearl, lithospermum, bletilla striata, garden burnet and rheum officinale according to the weight parts, uniformly mixing, drying at 65 ℃ for 30 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a 70-mesh sieve; then drying for 30 minutes at 65 ℃, and uniformly stirring while drying; sterilizing with ultraviolet ray for 40 min, pulverizing into 220 mesh fine powder, and mixing; soaking in oleum sesami under stirring for 2 days;
2) weighing the angelica, the pseudo-ginseng, the typhonium giganteum and the common cnidium fruit in parts by weight, uniformly mixing, drying at 65 ℃ for 15 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a 80-mesh sieve; adding the weight of the angelica, the pseudo-ginseng, the typhonium giganteum and the common cnidium fruit and 2.5 times of ethanol with the mass concentration of 70 percent, heating at 60 ℃, carrying out reflux extraction for 3 times, carrying out 1.5 hours each time, heating and concentrating the prepared ethanol extract at 65 ℃ until the concentration of the liquid medicine is 0.3g crude drug/ml, and drying into powder to obtain ethanol extraction dry powder for later use;
3) adding 5 times of water into the above-mentioned portions of broom cypress fruit, honeysuckle flower and cinnamon bark, heating and boiling for 3 hr, extracting; adding 5 times of water, heating and boiling for 1 hr, and extracting; mixing the two extractive solutions, and filtering;
4) cleaning the mint and the ampelopsis japonica according to the parts by weight, chopping, pounding, adding 6 times of distilled water, uniformly stirring, and filtering to obtain juice for later use;
5) chopping the sophora flavescens ait in parts by weight, steaming the chopped sophora flavescens ait in vinegar for 2 hours, adding borneol, pearl powder and honey in parts by weight, decocting the mixture for 2 hours, filtering the decoction by using a 500-mesh sieve, and extracting liquid medicine for later use;
6) adding the chlorhexidine acetate, miconazole nitrate, amoxicillin, cephalexin and furazolidone powder in parts by weight into a conventional regulating reagent, and regulating the pH value to a specified range for later use;
7) adding the reagent prepared in the step 6) into the product obtained in the step 1), stirring and mixing, and extracting liquid medicine for later use;
8) mixing and decocting the products obtained in the steps 2-5) and 7) for 2 times, wherein the first time is 3.5 hours, and the second time is 1.5 hours, filtering the mixture by using a 600-mesh sieve, and extracting liquid medicine for later use;
9) adding a pH adjusting reagent into the liquid medicine obtained in the step 8), adjusting the pH value to a specified range, bottling and sealing.
Wherein, the PH value is 5.8, and the superfine crusher is a CF airflow superfine crusher.
Example 3
A nursing liquid medicine for treating burns and scalds comprises Chinese and western medicine components, and the nursing liquid medicine comprises the following components in parts by weight: 800g of white sesame oil, 40g of mother-of-pearl, 120g of lithospermum, 20g of borneol, 100g of bletilla striata, 100g of sanguisorba officinalis, 250g of rheum officinale, 50g of angelica sinensis, 120g of sophora flavescens, 100g of typhonium giganteum, 200g of fructus cnidii, 50g of fructus kochiae, 150g of honeysuckle, 50g of cinnamomum cassia, 80g of mint, 50g of ampelopsis japonica, 80g of panax notoginseng, 50g of pearl powder, 5g of honey, 1g of chlorhexidine acetate, 2g of miconazole nitrate, 2g of amoxicillin, 2g of cephalexin and 2g of furazolidone powder.
In addition, the method for preparing the nursing liquid medicine for treating burns and scalds comprises the following steps:
1) weighing rinsed and dried or aired mother-of-pearl, lithospermum, bletilla striata, garden burnet and rheum officinale according to the weight parts, uniformly mixing, drying at the temperature of 55-65 ℃ for 30-40 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a sieve of 60-70 meshes; then drying for 20-30 minutes at 65-75 ℃, and uniformly stirring while drying; then sterilizing the mixture by using ultraviolet rays for 40-60 minutes, then putting the mixture into a superfine pulverizer to pulverize the mixture into fine powder which is sieved by a 200-220-mesh sieve, and uniformly mixing the fine powder; putting the sesame seeds into the white sesame oil, stirring and soaking for 2-3 days for later use;
2) weighing the angelica, the pseudo-ginseng, the typhonium giganteum and the fructus cnidii in parts by weight, uniformly mixing, drying at 55-65 ℃ for 15-20 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a sieve of 70-80 meshes; adding the weight of angelica, pseudo-ginseng, typhonium giganteum and fructus cnidii and 2.5 times of ethanol with the mass concentration of 70-75%, heating at 50-60 ℃, carrying out reflux extraction for 3 times, 1.5-2.5 hours each time, heating and concentrating the prepared ethanol extract at 55-65 ℃ until the concentration of the liquid medicine is 0.3g crude drug/ml, and drying into powder to obtain ethanol extraction dry powder for later use;
3) adding 5-6 times of water into the above components in parts by weight, heating and boiling for 2-3 hours, and extracting; adding 5 times of water, heating and boiling for 1-2 hours, and extracting; mixing the two extractive solutions, and filtering;
4) cleaning the mint and the ampelopsis japonica according to the parts by weight, chopping, pounding, adding 5-6 times of distilled water, uniformly stirring, and filtering to obtain a juice for later use;
5) chopping the sophora flavescens ait in parts by weight, steaming the chopped sophora flavescens ait in vinegar for 2 hours, adding borneol, pearl powder and honey in parts by weight, decocting the mixture for 2 to 5 hours, filtering the mixture by using a 500-mesh sieve, and extracting liquid medicine for later use;
6) adding the chlorhexidine acetate, miconazole nitrate, amoxicillin, cephalexin and furazolidone powder in parts by weight into a conventional regulating reagent, and regulating the pH value to a specified range for later use;
7) adding the reagent prepared in the step 6) into the product obtained in the step 1), stirring and mixing, and extracting liquid medicine for later use;
8) mixing and decocting the products obtained in the steps 2-5) and 7) for 2 times, wherein the first time lasts for 2.5-3.5 hours, and the second time lasts for 1.5-2.5 hours, filtering the mixture by using a 600-mesh sieve, and extracting liquid medicine for later use;
9) adding a pH adjusting reagent into the liquid medicine obtained in the step 8), adjusting the pH value to a specified range, bottling and sealing.
Wherein the pH value is 5.3-5.8, and the superfine crusher is a CF airflow superfine crusher.
Clinical practice
Case 1: Wu-Chi, male, age 44, has poor curative effect on liquefied gas burn for one week. The part after being coated with the nursing liquid medicine of the invention for one month is healed without any scar.
Case 2: yan A certain female is 50 years old, after being scalded by boiled water, the local treatment is carried out for 5 days, the effect is not good, the body temperature is 39.2 ℃ when the patient is in a treatment, a large amount of water is drunk, the lips are cracked, the dehydration symptom is obvious, the oral Chinese medicinal fluid supplement and the external preparation for treating the Shore burn are adopted immediately, the dehydration symptom disappears after 5 days, and the patient can be cured in 27 days of treatment in our hospital. After the return visit, a little scar is left and the functional disorder is not caused. The medicine liquid is applied for 10 days to cure the disease. Leaving only a slight scar without dysfunction.
In addition, the traditional Chinese medicine is used for special clinical research.
Clinical trial
Object: the total number of patients is 300, and the age is 35-60 years. The number of the first degree burn and scald patients is 50, the number of the second degree burn and scald patients is 100, and the number of the third degree burn and scald patients is 150.
Diagnostic criteria:
the method has the following advantages: the burn and scald symptoms are obviously improved.
The effect is obvious: the scar is completely eliminated, and the medicine is not continuously applied to the face as usual.
The effect is general: has certain scar removing effect, but still needs to be taken continuously.
Effective, but not obvious: the scar-removing effect is poor, and the medicine needs to be continuously taken.
No effect is achieved: the scar is not improved and needs to be treated by other medicines.
The method comprises the following steps: the nursing liquid medicine in the embodiment is applied once a day in the morning and at night, and is observed by follow-up for 2 months.
As a result: the cure rate of the treatment is 80%; the total effective rate is 95.5%. The diagnosis of the disease condition is informed of the diagnosis of the doctor issued by the regular hospital.
In order to enhance the effect of the traditional Chinese medicine, 15-20 parts by weight of sapanwood, 10-15 parts by weight of myrrh and 5-8 parts by weight of wormwood can be added into the components. Drying sappan wood, myrrh and wormwood for 30-40 minutes at 60-65 ℃, uniformly stirring while drying, then crushing into fine materials by using a crusher, sieving by using a 280-mesh sieve, directly mixing the fine materials sieved by the 280-mesh sieve into the rock sophora flavescens in the step 5), steaming for 2 hours by using vinegar, then adding borneol, pearl powder and honey in parts by weight, decocting for 2 hours, filtering by using a 500-mesh sieve, and extracting liquid medicine for later use; the other steps are the same as above.
The nursing liquid medicine for treating burns and scalds is convenient to apply, short in treatment course, quick in effect, free of toxic and side effects and free of drug dependence. The nursing liquid medicine is combined with the Chinese and Western medicines, has quick analgesic effect and strong healing capacity, and shortens one third of the common treatment course; has good anti-inflammatory and antibacterial effects, and has inhibitory effect on common drug-resistant bacteria, especially on Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Candida albicans common in burn and scald. The raw material component resource of the nursing liquid medicine for treating burns and scalds is sufficient and guaranteed, the efficiency is high, and the economic benefit and the social benefit are obvious. Finally, the preparation method of the nursing liquid medicine for treating burns and scalds is simple and easy to implement, low in cost and convenient to popularize.
The foregoing is directed to preferred embodiments of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow. However, any simple modification, equivalent change and modification of the above embodiments according to the technical essence of the present invention are within the protection scope of the technical solution of the present invention.
Claims (6)
1. A nursing liquid medicine for treating burns and scalds comprises Chinese and western medicine components and is characterized in that the nursing liquid medicine consists of the following components in parts by weight: 50-80 parts of white sesame oil, 4-10 parts of mother-of-pearl, 2-12 parts of lithospermum, 2-9 parts of borneol, 5-10 parts of bletilla striata, 10-15 parts of sanguisorba officinalis, 20-25 parts of rheum officinale, 5-15 parts of angelica sinensis, 8-12 parts of sophora flavescens, 10-15 parts of typhonium giganteum, 15-20 parts of fructus cnidii, 5-10 parts of fructus kochiae, 12-15 parts of honeysuckle, 5-10 parts of cinnamomum cassia, 5-8 parts of mint, 5-10 parts of ampelopsis japonica, 5-8 parts of pseudo-ginseng, 5-8 parts of pearl powder, 0.3-0.5 part of honey, 0.1-0.2 part of chlorhexidine acetate, 0.1-0.2 part of miconazole nitrate, 0.2-0.5 part of amoxicillin, 0.1-0.2 part of cefalexin and 0.2-0.5 part of furazolidone powder.
2. The nursing liquid medicine for treating burns and scalds according to claim 1, which is characterized by comprising the following components in parts by weight: 60 parts of white sesame oil, 7 parts of mother-of-pearl, 7 parts of lithospermum, 5 parts of borneol, 8 parts of bletilla striata, 12 parts of sanguisorba officinalis, 22 parts of rheum officinale, 10 parts of angelica sinensis, 10 parts of sophora flavescens, 13 parts of typhonium giganteum, 18 parts of fructus cnidii, 7 parts of broom cypress fruit, 14 parts of honeysuckle flower, 8 parts of cinnamomum cassia, 6 parts of mint, 7 parts of ampelopsis japonica, 7 parts of pseudo-ginseng, 6 parts of pearl powder, 0.4 part of honey, 0.1 part of chlorhexidine acetate, 0.2 part of miconazole nitrate, 0.4 part of amoxicillin, 0.2 part of cephalexin and 0.2 part of furazolidone powder.
3. A method for preparing a liquid nursing medicament for treating burns and scalds according to claim 1 or 2, characterized in that the method comprises the following steps:
1) weighing rinsed and dried or aired mother-of-pearl, lithospermum, bletilla striata, garden burnet and rheum officinale according to the weight parts, uniformly mixing, drying at the temperature of 55-65 ℃ for 30-40 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a sieve of 60-70 meshes; then drying for 20-30 minutes at 65-75 ℃, and uniformly stirring while drying; then sterilizing the mixture by using ultraviolet rays for 40-60 minutes, then putting the mixture into a superfine pulverizer to pulverize the mixture into fine powder which is sieved by a 200-220-mesh sieve, and uniformly mixing the fine powder; putting the sesame seeds into the white sesame oil, stirring and soaking for 2-3 days for later use;
2) weighing the angelica, the pseudo-ginseng, the typhonium giganteum and the fructus cnidii in parts by weight, uniformly mixing, drying at 55-65 ℃ for 15-20 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a sieve of 70-80 meshes; adding the weight of angelica, pseudo-ginseng, typhonium giganteum and fructus cnidii and 2.5 times of ethanol with the mass concentration of 70-75%, heating at 50-60 ℃, carrying out reflux extraction for 3 times, 1.5-2.5 hours each time, heating and concentrating the prepared ethanol extract at 55-65 ℃ until the concentration of the liquid medicine is 0.3g crude drug/ml, and drying into powder to obtain ethanol extraction dry powder for later use;
3) adding 5-6 times of water into the above components in parts by weight, heating and boiling for 2-3 hours, and extracting; adding 5 times of water, heating and boiling for 1-2 hours, and extracting; mixing the two extractive solutions, and filtering;
4) cleaning the mint and the ampelopsis japonica according to the parts by weight, chopping, pounding, adding 5-6 times of distilled water, uniformly stirring, and filtering to obtain a juice for later use;
5) chopping the sophora flavescens ait in parts by weight, steaming the chopped sophora flavescens ait in vinegar for 2 hours, adding borneol, pearl powder and honey in parts by weight, decocting the mixture for 2 to 5 hours, filtering the mixture by using a 500-mesh sieve, and extracting liquid medicine for later use;
6) adding the chlorhexidine acetate, miconazole nitrate, amoxicillin, cephalexin and furazolidone powder in parts by weight into a conventional regulating reagent, and regulating the pH value to a specified range for later use;
7) adding the reagent prepared in the step 6) into the product obtained in the step 1), stirring and mixing, and extracting liquid medicine for later use;
8) mixing and decocting the products obtained in the steps 2-5) and 7) for 2 times, wherein the first time lasts for 2.5-3.5 hours, and the second time lasts for 1.5-2.5 hours, filtering the mixture by using a 600-mesh sieve, and extracting liquid medicine for later use;
9) adding a pH adjusting reagent into the liquid medicine obtained in the step 8), adjusting the pH value to a specified range, bottling and sealing.
4. The method for preparing nursing liquid medicine for treating burns and scalds according to claim 3, characterized in that 1 part by weight of the raw material is 10 g.
5. The method for preparing nursing liquid medicine for treating burns and scalds according to claim 3 or 4, characterized in that the pH value is 5.3-5.8.
6. The method for preparing nursing liquid medicine for treating burns and scalds according to claim 5, wherein the ultra-fine pulverizer is a CF gas flow ultra-fine pulverizer.
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