CN103721189A - Meningeoma nursing medicine and preparation method thereof - Google Patents
Meningeoma nursing medicine and preparation method thereof Download PDFInfo
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- CN103721189A CN103721189A CN201310739355.8A CN201310739355A CN103721189A CN 103721189 A CN103721189 A CN 103721189A CN 201310739355 A CN201310739355 A CN 201310739355A CN 103721189 A CN103721189 A CN 103721189A
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Abstract
The invention discloses a meningeoma nursing medicine and a preparation method thereof. The nursing medicine is a formula formed by combining traditional Chinese medicine and western medicine, wherein the western medicine comprises the following components: dichloro diethylamine, cyclophosphamide, ifosfamide, melphalan, chlorambucil, thiotepa, mitomycin, busulfan, lomustine, carmustine, temozolomide and carboplatin. The traditional Chinese medicine comprises the following components: Oldenlandia diffusa, dangshen, honey-fried licorice root, fructus forsythiae, realgar, edible tulip, Schisandra chinensis, ginseng, soroseris, beautyberry leaf, radix curcumae, hawthorn, pheretima, gastrodia elata, Minoru thorns, Rehmannia Glutinosa, Ligusticum wallichii, Angelica sinensis, Polygonum cuspidatum, bamboo leaf, radix semiaquilegiae, red flower, white paeony root, pubescent holly root, fried monkshood, herba eupatorii, ambergris, fingered citron, Radix Aucklandiae, radix scutellariae, radix bupleuri and serrate rabdosia herb; the meningeoma nursing medicine has the advantages of obvious treatment effect, low disease relapsing rate and low side effect.
Description
Technical field
The present invention relates to a kind of meningioma care drug and preparation method thereof.
Background technology
Meningioma can be divided into intracranial meningeoma and ectopic meningioma, and the former is formed by intracranial arachnoid cell, and the latter refers to the meningioma of the histoorgan generation covering without meninges, mainly by the residual arachnoidea microstructure evolution of period of embryo, is formed.Predilection site has scalp, skull, eye socket, nasal sinuses, Trigeminal Semilunar Ganglion, cerebral dura mater skin etc.Meningioma has optimum and pernicious, and most of meningioma is all optimum, can take operation or medicine to treat and control, but surgery cost is expensive compared with medicine, and relapse rate is very high; And Drug therapy, because being nearly all Western medicine now on the market, thus very large of side effect, and unsatisfactory curative effect.
Summary of the invention
Technical problem to be solved by this invention is to provide one and has evident in efficacyly, is difficult for recurrence, and the meningioma care drug having no side effect.
For addressing the above problem, the present invention is achieved through the following technical solutions:
A kind of meningioma care drug, described this care drug is Chinese medicine and western medicine combined formulation, described Western medicine formula is: mechlorethamine, cyclophosphamide, ifosfamide, melphalan, benzenebutanoic acid peace mustard, thiophene are for group, mitomycin, busulfan, chlorethyl cyclohexyl nitrosourea, card ammonia mustard, temozolomide and carboplatin, described Western medicine weight portion proportioning is: mechlorethamine 0.4mg/kg, cyclophosphamide 3mg/kg, ifosfamide 1.2g/m
2, melphalan 0.15mg/kg, benzenebutanoic acid peace mustard 0.1mg/kg, thiophene be for sending 0.3mg/kg, mitomycin 20mg/m
2, busulfan 1.8mg/m
2, chlorethyl cyclohexyl nitrosourea 130mg/m
2, card ammonia mustard 150mg/m
2, temozolomide 150mg/m
2and carboplatin 360mg/m
2, described Chinese medicine formula is: Herba Hedyotidis Diffusae, Radix Codonopsis, Radix Glycyrrhizae Preparata, Fructus Forsythiae, Realgar, Pseudobulbus Cremastrae Seu Pleiones, Fructus Schisandrae Chinensis, Radix Ginseng, thin,tough silk hair chrysanthemum, Folium Callicarpae Formosanae, Radix Curcumae, Fructus Crataegi, LUMBRICUS, Rhizoma Gastrodiae, Semen euryales, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Angelicae Sinensis, speckle village root, Folium Bambusae, Radix Semiaquilegiae, Flos Carthami, the Radix Paeoniae Alba, Radix Ilicis Pubescentis, Radix Aconiti Lateralis Preparata, Folium Eupatorii, Ambra Grisea, Fructus Citri Sarcodactylis, the Radix Aucklandiae, Radix Scutellariae, Radix Bupleuri, Fructus Aurantii and Herba Rabdosiae Lophanthoidis, described each Chinese herbal medicine weight portion proportioning is: Herba Hedyotidis Diffusae 20g, Radix Codonopsis 14g, Radix Glycyrrhizae Preparata 26g, Fructus Forsythiae 10g, Realgar 6g, Pseudobulbus Cremastrae Seu Pleiones 25g, Fructus Schisandrae Chinensis 15g, Radix Ginseng 8g, thin,tough silk hair chrysanthemum 30g, Folium Callicarpae Formosanae 25g, Radix Curcumae 25g, Fructus Crataegi 30g, LUMBRICUS 10g, Rhizoma Gastrodiae 5g, Semen euryales 10g, Radix Rehmanniae Preparata 15g, Rhizoma Chuanxiong 25g, Radix Angelicae Sinensis 15g, speckle village root 5g, Folium Bambusae 20g, Radix Semiaquilegiae 17g, Flos Carthami 40g, Radix Paeoniae Alba 20g, Radix Ilicis Pubescentis 35g, Radix Aconiti Lateralis Preparata 12g, Folium Eupatorii 15g, Ambra Grisea 10g, Fructus Citri Sarcodactylis 7g, Radix Aucklandiae 20g, Radix Scutellariae 30g, Radix Bupleuri 15g, Fructus Aurantii 10g and Herba Rabdosiae Lophanthoidis 35g.
Another technical problem to be solved by this invention is to provide one and has evident in efficacyly, is difficult for recurrence, and the preparation method of the meningioma care drug having no side effect.
The present invention is achieved through the following technical solutions: the manufacturing process of described a kind of meningioma care drug is as follows:
A, mechlorethamine, cyclophosphamide, ifosfamide, melphalan, benzenebutanoic acid peace mustard, thiophene are added to conventional debugging agent for group, mitomycin, busulfan, chlorethyl cyclohexyl nitrosourea, card ammonia mustard, temozolomide and carboplatin, pH value is transferred to prescribed limit, standby;
B, Radix Codonopsis and Radix Ginseng are cut off, with steaming with vinegar 2 hours, then add Lac regis apis and distilled water to decoct 2-5 hour, filter with 500 mesh sieves, extraction medicinal liquid is standby;
C, by Herba Hedyotidis Diffusae, Radix Glycyrrhizae Preparata, Fructus Forsythiae, Realgar, Pseudobulbus Cremastrae Seu Pleiones, Fructus Schisandrae Chinensis, thin,tough silk hair chrysanthemum, Folium Callicarpae Formosanae, Radix Curcumae, Fructus Crataegi, LUMBRICUS, Rhizoma Gastrodiae, Semen euryales, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Angelicae Sinensis, speckle village root, Folium Bambusae, Radix Semiaquilegiae, Flos Carthami, the Radix Paeoniae Alba, Radix Ilicis Pubescentis, Radix Aconiti Lateralis Preparata, Folium Eupatorii, Ambra Grisea, Fructus Citri Sarcodactylis, the Radix Aucklandiae, Radix Scutellariae, Radix Bupleuri, Fructus Aurantii and Herba Rabdosiae Lophanthoidis decoct with water 3 times, the water yield was not there to be powder to be advisable, decocting time is 3-5 hour for the first time, decocting time is 2-3 hour for the second time, decocting time is 1-2 hour for the third time, decoct latter standing 15 hours, with 500 mesh sieves filtrations, extraction medicinal liquid is standby,
D, the reagent that step " A " is modulated join in the medicinal liquid of step " B " extraction, are uniformly mixed, and extract medicinal liquid standby;
E, the medicinal liquid that step " D " is extracted mix and decoct 2 times with the medicinal liquid extracting in step " C ", and 3 hours for the first time, 2 hours for the second time, with 600 mesh sieves filtrations, extract medicinal liquid, standby;
F, the medicinal liquid of " E " step gained is added to PH debugging agent, pH value is adjusted to prescribed limit, the capping of bottling afterwards.
The pharmacology introduction of some Chinese herbal medicine in product care drug of the present invention:
Folium Callicarpae Formosanae: taste is micro-pungent, bitter, property is flat.There is the effect of hemostasis, dissipating blood stasis and detumescence.
Herba Hedyotidis Diffusae: bitter in the mouth, light, cold in nature.There is the effect of heat-clearing and toxic substances removing, medicinal powder for relieving pain knot.
Radix Codonopsis: sweet in the mouth, property is flat.The effect that there is invigorating the spleen to benefit the lung, promotes the production of body fluid and nourish blood.
Thin,tough silk hair chrysanthemum: bitter in the mouth, cold in nature.There is the effect of heat-clearing and toxic substances removing.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.There is blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.
Radix Scutellariae: bitter in the mouth, cold in nature.There is the effect of heat clearing and damp drying, eliminating fire and detoxication and hemostasis.
Radix Ilicis Pubescentis: bitter in the mouth, property is flat.There is the effect of heat-clearing and toxic substances removing, blood circulation and channel invigorating.
Radix Bupleuri: bitter in the mouth, cold nature.Have that liver heat removing is brought down a fever, the effect of reducing swelling and alleviating pain.
Folium Eupatorii: acrid in the mouth, property is flat.There is the effect of removing dampness by means of aromatics, the appetizing of heart spleen.
The beneficial effect of a kind of meningioma care drug of the present invention and preparation method thereof is: adopt Chinese medicine and western medicine in conjunction with being prepared from, be difficult for recurrence, side effect is low, and evident in efficacy.
The specific embodiment
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Of the present invention is a kind of meningioma care drug, and described this care drug is Chinese medicine and western medicine combined formulation, described Western medicine formula is: mechlorethamine, cyclophosphamide, ifosfamide, melphalan, benzenebutanoic acid peace mustard, thiophene are for group, mitomycin, busulfan, chlorethyl cyclohexyl nitrosourea, card ammonia mustard, temozolomide and carboplatin, described Western medicine weight portion proportioning is: mechlorethamine 0.4mg/kg, cyclophosphamide 3mg/kg, ifosfamide 1.2g/m
2, melphalan 0.15mg/kg, benzenebutanoic acid peace mustard 0.1mg/kg, thiophene be for sending 0.3mg/kg, mitomycin 20mg/m
2, busulfan 1.8mg/m
2, chlorethyl cyclohexyl nitrosourea 130mg/m
2, card ammonia mustard 150mg/m
2, temozolomide 150mg/m
2and carboplatin 360mg/m
2, described Chinese medicine formula is: Herba Hedyotidis Diffusae, Radix Codonopsis, Radix Glycyrrhizae Preparata, Fructus Forsythiae, Realgar, Pseudobulbus Cremastrae Seu Pleiones, Fructus Schisandrae Chinensis, Radix Ginseng, thin,tough silk hair chrysanthemum, Folium Callicarpae Formosanae, Radix Curcumae, Fructus Crataegi, LUMBRICUS, Rhizoma Gastrodiae, Semen euryales, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Angelicae Sinensis, speckle village root, Folium Bambusae, Radix Semiaquilegiae, Flos Carthami, the Radix Paeoniae Alba, Radix Ilicis Pubescentis, Radix Aconiti Lateralis Preparata, Folium Eupatorii, Ambra Grisea, Fructus Citri Sarcodactylis, the Radix Aucklandiae, Radix Scutellariae, Radix Bupleuri, Fructus Aurantii and Herba Rabdosiae Lophanthoidis, described each Chinese herbal medicine weight portion proportioning is: Herba Hedyotidis Diffusae 20g, Radix Codonopsis 14g, Radix Glycyrrhizae Preparata 26g, Fructus Forsythiae 10g, Realgar 6g, Pseudobulbus Cremastrae Seu Pleiones 25g, Fructus Schisandrae Chinensis 15g, Radix Ginseng 8g, thin,tough silk hair chrysanthemum 30g, Folium Callicarpae Formosanae 25g, Radix Curcumae 25g, Fructus Crataegi 30g, LUMBRICUS 10g, Rhizoma Gastrodiae 5g, Semen euryales 10g, Radix Rehmanniae Preparata 15g, Rhizoma Chuanxiong 25g, Radix Angelicae Sinensis 15g, speckle village root 5g, Folium Bambusae 20g, Radix Semiaquilegiae 17g, Flos Carthami 40g, Radix Paeoniae Alba 20g, Radix Ilicis Pubescentis 35g, Radix Aconiti Lateralis Preparata 12g, Folium Eupatorii 15g, Ambra Grisea 10g, Fructus Citri Sarcodactylis 7g, Radix Aucklandiae 20g, Radix Scutellariae 30g, Radix Bupleuri 15g, Fructus Aurantii 10g and Herba Rabdosiae Lophanthoidis 35g.
The preparation process of described a kind of meningioma care drug is as follows:
A, mechlorethamine, cyclophosphamide, ifosfamide, melphalan, benzenebutanoic acid peace mustard, thiophene are added to conventional debugging agent for group, mitomycin, busulfan, chlorethyl cyclohexyl nitrosourea, card ammonia mustard, temozolomide and carboplatin, pH value is transferred to prescribed limit, standby;
B, Radix Codonopsis and Radix Ginseng are cut off, with steaming with vinegar 2 hours, then add Lac regis apis and distilled water to decoct 2-5 hour, filter with 500 mesh sieves, extraction medicinal liquid is standby;
C, by Herba Hedyotidis Diffusae, Radix Glycyrrhizae Preparata, Fructus Forsythiae, Realgar, Pseudobulbus Cremastrae Seu Pleiones, Fructus Schisandrae Chinensis, thin,tough silk hair chrysanthemum, Folium Callicarpae Formosanae, Radix Curcumae, Fructus Crataegi, LUMBRICUS, Rhizoma Gastrodiae, Semen euryales, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Angelicae Sinensis, speckle village root, Folium Bambusae, Radix Semiaquilegiae, Flos Carthami, the Radix Paeoniae Alba, Radix Ilicis Pubescentis, Radix Aconiti Lateralis Preparata, Folium Eupatorii, Ambra Grisea, Fructus Citri Sarcodactylis, the Radix Aucklandiae, Radix Scutellariae, Radix Bupleuri, Fructus Aurantii and Herba Rabdosiae Lophanthoidis decoct with water 3 times, the water yield was not there to be powder to be advisable, decocting time is 3-5 hour for the first time, decocting time is 2-3 hour for the second time, decocting time is 1-2 hour for the third time, decoct latter standing 15 hours, with 500 mesh sieves filtrations, extraction medicinal liquid is standby,
D, the reagent that step " A " is modulated join in the medicinal liquid of step " B " extraction, are uniformly mixed, and extract medicinal liquid standby;
E, the medicinal liquid that step " D " is extracted mix and decoct 2 times with the medicinal liquid extracting in step " C ", and 3 hours for the first time, 2 hours for the second time, with 600 mesh sieves filtrations, extract medicinal liquid, standby;
F, the medicinal liquid of " E " step gained is added to PH debugging agent, pH value is adjusted to prescribed limit, the capping of bottling afterwards.
The using method of product meningioma care drug of the present invention: adopt muscle injection mode, each consumption 3-5g,
One week once, two months was a course for the treatment of.
Experimental example 1:
Experimental subject: 200 have the people of meningioma performance, the age, between 35-50 year, according to using different pharmaceutical, is divided into two groups, every group of 100 people.
Experimental technique: two groups of personnel use respectively the medicine of 2 months, first group of patient infusion product medicine of the present invention, second group of patient infusion other medicines.
Experimental result:
Experimental example 2:
Experimental subject: the patient after 150 meningiomas surgeries, the age, between 35-50 year, according to using medicine difference, is divided into two groups, every group of 75 people.
Experimental technique: two groups of personnel use respectively the medicine of 2 months, first group is used product medicine of the present invention, and second group is used other medicines.
Experiment purpose: observe hands postoperative patient and carry out after medicaments nursing, have or not recurrence and side effect.
(note: the unstable expression of situation is not recurrence temporarily, but has very large probability to recur.）
From above experimental result, use the meningioma care drug of product of the present invention, no matter be control or the treatment to meningioma, or the recurrence of meningioma is prevented to have the curative effect of highly significant; And product of the present invention adopts Chinese medicine and western medicine in conjunction with preparation, when having promoted curative effect, has significantly reduced the side effect of medicine to human body.
Typical case:
Remaining certain, 36 years old, in 2009, find that there is meningioma, through excision, obtained recovery from illness.Can after half a year, just find recurrence of Meningiomas, because recurrence has appearred in operation before, remaining certain this time decision adopts Drug therapy, regularly to hospital, injects care drug, can all there is no what improvement by 2 wheat harvesting periods, remaining certain just changed use medicine, bring into use product care drug of the present invention, through 2 months adhere to, use, the meningioma of certain is controlled more than the examination in hospital, diameter has been less than 1CM, and diminishes continuing.
Below the present invention is described in detail, the above, be only the present invention's preferred embodiment, when not limiting the scope of the present invention, allly according to the application's scope, does impartial variation and modification, all should still belong in covering scope of the present invention.
Claims (2)
1. a meningioma care drug, described this care drug is Chinese medicine and western medicine combined formulation, described Western medicine formula is: mechlorethamine, cyclophosphamide, ifosfamide, melphalan, benzenebutanoic acid peace mustard, thiophene are for group, mitomycin, busulfan, chlorethyl cyclohexyl nitrosourea, card ammonia mustard, temozolomide and carboplatin, described Western medicine weight portion proportioning is: mechlorethamine 0.4mg/kg, cyclophosphamide 3mg/kg, ifosfamide 1.2g/m
2, melphalan 0.15mg/kg, benzenebutanoic acid peace mustard 0.1mg/kg, thiophene be for sending 0.3mg/kg, mitomycin 20mg/m
2, busulfan 1.8mg/m
2, chlorethyl cyclohexyl nitrosourea 130mg/m
2, card ammonia mustard 150mg/m
2, temozolomide 150mg/m
2and carboplatin 360mg/m
2, described Chinese medicine formula is: Herba Hedyotidis Diffusae, Radix Codonopsis, Radix Glycyrrhizae Preparata, Fructus Forsythiae, Realgar, Pseudobulbus Cremastrae Seu Pleiones, Fructus Schisandrae Chinensis, Radix Ginseng, thin,tough silk hair chrysanthemum, Folium Callicarpae Formosanae, Radix Curcumae, Fructus Crataegi, LUMBRICUS, Rhizoma Gastrodiae, Semen euryales, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Angelicae Sinensis, speckle village root, Folium Bambusae, Radix Semiaquilegiae, Flos Carthami, the Radix Paeoniae Alba, Radix Ilicis Pubescentis, Radix Aconiti Lateralis Preparata, Folium Eupatorii, Ambra Grisea, Fructus Citri Sarcodactylis, the Radix Aucklandiae, Radix Scutellariae, Radix Bupleuri, Fructus Aurantii and Herba Rabdosiae Lophanthoidis, described each Chinese herbal medicine weight portion proportioning is: Herba Hedyotidis Diffusae 20g, Radix Codonopsis 14g, Radix Glycyrrhizae Preparata 26g, Fructus Forsythiae 10g, Realgar 6g, Pseudobulbus Cremastrae Seu Pleiones 25g, Fructus Schisandrae Chinensis 15g, Radix Ginseng 8g, thin,tough silk hair chrysanthemum 30g, Folium Callicarpae Formosanae 25g, Radix Curcumae 25g, Fructus Crataegi 30g, LUMBRICUS 10g, Rhizoma Gastrodiae 5g, Semen euryales 10g, Radix Rehmanniae Preparata 15g, Rhizoma Chuanxiong 25g, Radix Angelicae Sinensis 15g, speckle village root 5g, Folium Bambusae 20g, Radix Semiaquilegiae 17g, Flos Carthami 40g, Radix Paeoniae Alba 20g, Radix Ilicis Pubescentis 35g, Radix Aconiti Lateralis Preparata 12g, Folium Eupatorii 15g, Ambra Grisea 10g, Fructus Citri Sarcodactylis 7g, Radix Aucklandiae 20g, Radix Scutellariae 30g, Radix Bupleuri 15g, Fructus Aurantii 10g and Herba Rabdosiae Lophanthoidis 35g.
2. a preparation method for meningioma care drug as claimed in claim 1, is characterized in that: comprise the following steps:
A, mechlorethamine, cyclophosphamide, ifosfamide, melphalan, benzenebutanoic acid peace mustard, thiophene are added to conventional debugging agent for group, mitomycin, busulfan, chlorethyl cyclohexyl nitrosourea, card ammonia mustard, temozolomide and carboplatin, pH value is transferred to prescribed limit, standby;
B, Radix Codonopsis and Radix Ginseng are cut off, with steaming with vinegar 2 hours, then add Lac regis apis and distilled water to decoct 2-5 hour, filter with 500 mesh sieves, extraction medicinal liquid is standby;
C, by Herba Hedyotidis Diffusae, Radix Glycyrrhizae Preparata, Fructus Forsythiae, Realgar, Pseudobulbus Cremastrae Seu Pleiones, Fructus Schisandrae Chinensis, thin,tough silk hair chrysanthemum, Folium Callicarpae Formosanae, Radix Curcumae, Fructus Crataegi, LUMBRICUS, Rhizoma Gastrodiae, Semen euryales, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Angelicae Sinensis, speckle village root, Folium Bambusae, Radix Semiaquilegiae, Flos Carthami, the Radix Paeoniae Alba, Radix Ilicis Pubescentis, Radix Aconiti Lateralis Preparata, Folium Eupatorii, Ambra Grisea, Fructus Citri Sarcodactylis, the Radix Aucklandiae, Radix Scutellariae, Radix Bupleuri, Fructus Aurantii and Herba Rabdosiae Lophanthoidis decoct with water 3 times, the water yield was not there to be powder to be advisable, decocting time is 3-5 hour for the first time, decocting time is 2-3 hour for the second time, decocting time is 1-2 hour for the third time, decoct latter standing 15 hours, with 500 mesh sieves filtrations, extraction medicinal liquid is standby,
D, the reagent that step " A " is modulated join in the medicinal liquid of step " B " extraction, are uniformly mixed, and extract medicinal liquid standby;
E, the medicinal liquid that step " D " is extracted mix and decoct 2 times with the medicinal liquid extracting in step " C ", and 3 hours for the first time, 2 hours for the second time, with 600 mesh sieves filtrations, extract medicinal liquid, standby;
F, the medicinal liquid of " E " step gained is added to PH debugging agent, pH value is adjusted to prescribed limit, the capping of bottling afterwards.
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| CN105267676A (en) * | 2015-10-16 | 2016-01-27 | 鞠进英 | Nursing medicine liquid for treating burns and scalds and method for preparing nursing medicine liquid |
| CN105535489A (en) * | 2016-01-11 | 2016-05-04 | 张宝英 | Care medicine composition used before operative anesthesia and preparation method thereof |
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Application publication date: 20140416 |
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