CN105535489A - Care medicine composition used before operative anesthesia and preparation method thereof - Google Patents
Care medicine composition used before operative anesthesia and preparation method thereof Download PDFInfo
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- CN105535489A CN105535489A CN201610015724.2A CN201610015724A CN105535489A CN 105535489 A CN105535489 A CN 105535489A CN 201610015724 A CN201610015724 A CN 201610015724A CN 105535489 A CN105535489 A CN 105535489A
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Abstract
The invention discloses a care medicine composition used before operative anesthesia and a preparation method thereof. The medicine composition is composed of Chinese herbal medicinal ingredients and Western medicinal ingredients. The Chinese herbal medicinal ingredients mainly comprise fruits of Celastrus rosthornianus Loes, sow thistle flower and seeds, rhapis excelsa, the root of Laxleaf Beautifulflower Millettia, all-grass of auriculate dichrocephala, pine among the Indian Bread, fructus terminaliae billericae, aizoon stonecrop herb, valerian, sandalwood extract and crowndaisy chrysanthemum extract. The Western medicinal ingredients mainly comprise aminomethylbenzoic acid, diaminocaproic acid, taurine and cefuroxime. The care medicine composition is scientifically matched according to different medicine effects and characteristics of Chinese and western medicine, is applied to according to indications, has the effects of soothing nerves and calming heart, relieving pain and removing swelling, resisting bacteria and diminishing inflammation, stopping bleeding, enhancing human body immunocompetence and resisting virus infection, and effectively eases preoperative tension, anxiety, fear and other psychic reactions of a patient. The care medicine composition used before operative anesthesia is simple in preparation technology, remarkable in treatment effect and gentle in medicine effect and has the good medical value.
Description
Technical field
The present invention relates to operation nursing practical technique field, particularly relate to a kind of for the care drug composition and method of making the same before surgery anesthesia.
Background technology
Modern society, the Medical Technology in west constantly spreads in China, compensate for Chinese tradition Chinese medicine some short slabs clinically to a great extent, the misery that can not only alleviate patient fast can also save the life of patient timely, operative treatment is exactly wherein most important a kind of medical means, operation conceptually refers to the treatment such as excision, stitching that doctor carries out with medical apparatus and instruments some position to patient body, with cutter, cut, operation that the apparatus such as pin carries out at body local, maintaining the health of patient with this, is the primary treatments of surgery.Removing pathological tissues, repair damage, transplant organ, improve the method such as function and morphology of body to maintain the health of human body.And before operation is implemented, in order to alleviate the pain of patient, must first anaesthetize patient, it is generally acknowledged, anesthesia is the reversibility function inhibitio of a kind of nervus centralis and the peripheral nervous system produced by medicine or additive method, the forfeiture of the feature of this suppression mainly pain sensation, therefore, the implication of anesthesia with medicine or additive method, entire patient or local is temporarily lost sensibility, and carries out operative treatment to reach painless object.Anesthesia is mainly divided into general anesthesia and local anesthesia two kinds: general anesthesia refers to and enters in body by anesthetics by suction, vein, intramuscular injection or rectal perfusion, central nervous system is suppressed, causes patient to realize and disappear and the process of the painless feel in the whole body; Local anesthesia utilizes local anesthetic as procaine, lignocaine etc., is injected at corresponding site and spinal nerves, plexus nervorum or nerve trunk and the thinner peripheral termination of nerve are blocked, a certain position of health is temporarily lost sensibility.Anesthesiology to have become in clinical medicine a special independent educational project, mainly comprising the research of Clinical Anaesthesiology, emergency resuscitation medical science, Intensive care therapeutics, Diagnosis and Treatment of Pain and other relevant medical and mechanism thereof, is the comprehensive branch of learning of a research anesthesia, analgesia, emergency resuscitation and serious symptom medical science.Wherein clinical anesthesia is the major part of modern anaesthesia.Relating to all process of anesthesia front-back wall average of operation periods, carrying out the front preparation of anesthesia, as understood the state of an illness, in conjunction with the optimal anesthesia of surgical selection and medicine.
In order to reduce the psychentonia before operation in patients, ensure that anesthesia and operation are carried out smoothly, regulate except some preoperative human bodies will be done, fasting is wanted before anaesthetizing, in case anesthesia, vomit during operation, miss the complication such as suction, suitably can give some medicaments nursings to the carrying out making human body can better coordinate operation, as tranquilizer, analgesic, the premedications such as anticholinergic agent, although Western medicine instant effect but how much have some side effect, the side effect of Chinese medicine is little but can not take effect fast, therefore only have effective by Integrated TCM, the adjustment comprehensive from preoperative many-side and nursing human body, just can reach the human body state before better surgery anesthesia, thus anesthesia and operation are completed smoothly, therefore just a kind of new medicine is needed to solve this difficult problem.
Summary of the invention
For making up the deficiencies in the prior art, the invention provides a kind of good effect, instant effect, having no side effect, easy to use for the care drug compositions before surgery anesthesia.
Another object of the present invention is to provide a kind of preparation method for the care drug compositions before surgery anesthesia.
For achieving the above object, technical scheme of the present invention is: a kind of for the care drug compositions before surgery anesthesia, described pharmaceutical composition is made up of Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients comprises following component: short handle fruits of Celastrus orbiculatus Thunb 35 ~ 68 parts, Semen Sonchi oleracei 32 ~ 60 parts, fernleaf hedge bamboo 29 ~ 57 parts, Radix Millettiae typicae 26 ~ 52 parts, Herba Dichrocephalae auriculatae 24 ~ 50 parts, Lignum Poria 23 ~ 45 parts, Fructus Terminaliae Billericae 19 ~ 43 parts, Herba Sedi Aizoon 18 ~ 34 parts, Rhizoma et radix valerianae 15 ~ 30 parts, Lignum Santali Albi extract 8.2 ~ 10 parts, Caulis et Folium Chrysanthemi segeti extract 6.4 ~ 9.8 parts, described western medicine composition comprises following component: aminomethylbenzoic acid 0.15 ~ 0.2 part, lysine 0.08 ~ 0.14 part, taurine 0.05 ~ 0.09 part, Zinacef 0.03 ~ 0.08 part.
Further, described pharmaceutical composition is made up of Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients comprises following component: short handle fruits of Celastrus orbiculatus Thunb 51.5 parts, Semen Sonchi oleracei 46 parts, fernleaf hedge bamboo 43 parts, Radix Millettiae typicae 39 parts, Herba Dichrocephalae auriculatae 37 parts, Lignum Poria 34 parts, Fructus Terminaliae Billericae 31 parts, Herba Sedi Aizoon 26 parts, Rhizoma et radix valerianae 22.5 parts, Lignum Santali Albi extract 9.1 parts, Caulis et Folium Chrysanthemi segeti extract 8.1 parts; Described western medicine composition comprises following component: aminomethylbenzoic acid 0.175 part, lysine 0.11 part, taurine 0.07 part, Zinacef 0.055 part.
Further, described Lignum Santali Albi extract is Oleum Santali albi, its preparation method is: fresh sandalwood heartwood cleaned up, the water putting into 5 ~ 8 times amount soaks 10 ~ 12h, the sandalwood heartwood of soaking is inserted in distil container and distills, steam distilling above water is selected to heat, distilling above water distills also known as water proof, refer on the sieve plate that raw material is placed in boiler, certain water yield is held to meet the enough saturated vapors of generation needed for distillation procedure under sieve plate, raw material bottom is not spattered with water for principle when water layer height seethes with excitement with water, distillation starts, first the bottom of a pan water layer is heated, until boiling, the low-pressure saturated steam produced from bottom to top adds thermal material layer by sieve plate, the bed of material forms water oil mixed vapour whole process to pot top is risen up into from saturated vapor, to be slowly advisable, distilling above water raw material only contacts with steam, the low-pressure saturated steam produced, because water capacity is large, be conducive to oil to steam, also be conducive to shortening distillation time, fuel saving, improve the quality of oil yield and oil, filter after obtaining distillate, Oleum Santali albi and Lignum Santali Albi hydrosol is comprised in filtrate, layering is there will be after filtrate being poured into liquid cyclone, extract upper strata material namely to obtain as Oleum Santali albi.
Further, described Caulis et Folium Chrysanthemi segeti method for preparing extractive is: fresh Caulis et Folium Chrysanthemi segeti is cut into the segment that 2 ~ 3cm is long, add the alcoholic solution of the mass concentration 75% of 5 times amount, after soaking 2 ~ 3h, insert after juice extractor is squeezed the juice and obtain filtering residue, extruding filtering residue obtains filtrate, filtrate is extracted with supercritical liquid extraction technique, arranging extracting pressure is 30 ~ 45MPa, carbon dioxide is extractant, operative temperature is 26 ~ 35 DEG C, the advantage of the supercritical liquid extraction technique of carbon dioxide is: critical temperature and critical pressure low, operating condition is gentle, few to the destruction of effective ingredient, a kind of and nontoxic like aqueous phase, cheap organic solvent, it is in use stablized, nontoxic, do not burn, safety, free from environmental pollution, and the oxidation of product can be avoided, not containing nitrate and harmful heavy metal in the extract of carbon dioxide, and remaining without hazardous solvent, when supercritical carbon dioxide extraction, the material be extracted is by reducing pressure, or raised temperature can be separated out, need not through extracting operation repeatedly, so supercritical carbon dioxide extraction flow process is simple, be particularly suitable for the Isolation and purification of medicine, the extract obtained filters with microporous membrane filtration again, by filtrate heating recovery ethanol, namely Caulis et Folium Chrysanthemi segeti extract is obtained after cooling.
For the care drug compositions before surgery anesthesia, the preparation method of described pharmaceutical composition is:
Step one: take short handle fruits of Celastrus orbiculatus Thunb according to described part by weight, Semen Sonchi oleracei, fernleaf hedge bamboo, Radix Millettiae typicae, Herba Dichrocephalae auriculatae, Lignum Poria, Fructus Terminaliae Billericae, Herba Sedi Aizoon, Rhizoma et radix valerianae washes with water totally respectively, mixing is placed on oven drying, arranging oven temperature is 60 ~ 68 DEG C, make the moisture of all medical materials lower than 5%, be ground into coarse powder, cross 20 ~ 30 mesh sieves, obtain Chinese medicine mixed powder, the ethanol of the mass concentration 95% of 3 times amount is added in described Chinese medicine mixed powder, after soaking 3 ~ 5h, add the pure water of its 12 ~ 15 times amount again, intense fire boils, then slow fire extracts 2 ~ 3h, filtration obtains filtrate a, give the pure water adding 10 ~ 12 times amount in the medicinal residues after filtering again, intense fire boils, then slow fire extracts 1 ~ 2h, extracting liquid filtering is obtained filtrate b, filtrate a and filtrate b is mixed, after leaving standstill 12h, concentrating under reduced pressure becomes extractum, 120 ~ 150 mesh sieves are crossed after spraying dry, extract powder is made after sterilizing,
Step 2: fresh sandalwood heartwood is cleaned up, the water putting into 5 ~ 8 times amount soaks 10 ~ 12h, the sandalwood heartwood of soaking is inserted in distil container and distills, steam distilling above water is selected to heat, distilling above water distills also known as water proof, refer on the sieve plate that raw material is placed in boiler, certain water yield is held to meet the enough saturated vapors of generation needed for distillation procedure under sieve plate, raw material bottom is not spattered with water for principle when water layer height seethes with excitement with water, distillation starts, first the bottom of a pan water layer is heated, until boiling, the low-pressure saturated steam produced from bottom to top adds thermal material layer by sieve plate, the bed of material forms water oil mixed vapour whole process to pot top is risen up into from saturated vapor, to be slowly advisable, distilling above water raw material only contacts with steam, the low-pressure saturated steam produced, because water capacity is large, be conducive to oil to steam, also be conducive to shortening distillation time, fuel saving, improve the quality of oil yield and oil, filter after obtaining distillate, Oleum Santali albi and Lignum Santali Albi hydrosol is comprised in filtrate, layering is there will be after filtrate being poured into liquid cyclone, namely extract upper strata material obtains as Oleum Santali albi,
Step 3: fresh Caulis et Folium Chrysanthemi segeti is cut into the segment that 2 ~ 3cm is long, add the alcoholic solution of the mass concentration 75% of 5 times amount, after soaking 2 ~ 3h, insert after juice extractor is squeezed the juice and obtain filtering residue, extruding filtering residue obtains filtrate, filtrate is extracted with supercritical liquid extraction technique, arranging extracting pressure is 30 ~ 45MPa, carbon dioxide is extractant, operative temperature is 26 ~ 35 DEG C, the advantage of the supercritical liquid extraction technique of carbon dioxide is: critical temperature and critical pressure low, operating condition is gentle, few to the destruction of effective ingredient, a kind of and nontoxic like aqueous phase, cheap organic solvent, it is in use stablized, nontoxic, do not burn, safety, free from environmental pollution, and the oxidation of product can be avoided, not containing nitrate and harmful heavy metal in the extract of carbon dioxide, and remaining without hazardous solvent, when supercritical carbon dioxide extraction, the material be extracted is by reducing pressure, or raised temperature can be separated out, need not through extracting operation repeatedly, so supercritical carbon dioxide extraction flow process is simple, be particularly suitable for the Isolation and purification of medicine, the extract obtained filters with microporous membrane filtration again, by filtrate heating recovery ethanol, namely Caulis et Folium Chrysanthemi segeti extract is obtained after cooling,
Step 4: the Lignum Santali Albi extract of extract powder obtained for step one and described composition by weight, Caulis et Folium Chrysanthemi segeti extract are mixed; add the aminomethylbenzoic acid of described composition by weight, lysine, taurine, Zinacef again; be placed in blender with after the rotating speed of 100r/min stirring 25min; be placed in air-stream type ultrafine pulverizer to pulverize; cross 300 mesh sieves; sterilizing is sealed up for safekeeping, namely obtains described for the care drug compositions before surgery anesthesia.
Further, a kind of preparation method for the care drug compositions before surgery anesthesia, described pharmaceutical composition adds required adjuvant can be prepared into capsule.
Further, a kind of preparation method for the care drug compositions before surgery anesthesia, described capsule preparation method thereof comprises the following steps:
Step one: take short handle fruits of Celastrus orbiculatus Thunb according to described part by weight, Semen Sonchi oleracei, fernleaf hedge bamboo, Radix Millettiae typicae, Herba Dichrocephalae auriculatae, Lignum Poria, Fructus Terminaliae Billericae, Herba Sedi Aizoon, Rhizoma et radix valerianae washes with water totally respectively, mixing is placed on oven drying, arranging oven temperature is 60 ~ 68 DEG C, make the moisture of all medical materials lower than 5%, be ground into coarse powder, cross 20 ~ 30 mesh sieves, obtain Chinese medicine mixed powder, the ethanol of the mass concentration 95% of 3 times amount is added in described Chinese medicine mixed powder, after soaking 3 ~ 5h, add the pure water of its 12 ~ 15 times amount again, intense fire boils, then slow fire extracts 2 ~ 3h, filtration obtains filtrate a, give the pure water adding 10 ~ 12 times amount in the medicinal residues after filtering again, intense fire boils, then slow fire extracts 1 ~ 2h, extracting liquid filtering is obtained filtrate b, filtrate a and filtrate b is mixed, after leaving standstill 12h, concentrating under reduced pressure becomes extractum, 120 ~ 150 mesh sieves are crossed after spraying dry, extract powder is made after sterilizing,
Step 2: fresh sandalwood heartwood is cleaned up, the water putting into 5 ~ 8 times amount soaks 10 ~ 12h, the sandalwood heartwood of soaking is inserted in distil container and distills, steam distilling above water is selected to heat, distilling above water distills also known as water proof, refer on the sieve plate that raw material is placed in boiler, certain water yield is held to meet the enough saturated vapors of generation needed for distillation procedure under sieve plate, raw material bottom is not spattered with water for principle when water layer height seethes with excitement with water, distillation starts, first the bottom of a pan water layer is heated, until boiling, the low-pressure saturated steam produced from bottom to top adds thermal material layer by sieve plate, the bed of material forms water oil mixed vapour whole process to pot top is risen up into from saturated vapor, to be slowly advisable, distilling above water raw material only contacts with steam, the low-pressure saturated steam produced, because water capacity is large, be conducive to oil to steam, also be conducive to shortening distillation time, fuel saving, improve the quality of oil yield and oil, filter after obtaining distillate, Oleum Santali albi and Lignum Santali Albi hydrosol is comprised in filtrate, layering is there will be after filtrate being poured into liquid cyclone, namely extract upper strata material obtains as Oleum Santali albi,
Step 3: fresh Caulis et Folium Chrysanthemi segeti is cut into the segment that 2 ~ 3cm is long, add the alcoholic solution of the mass concentration 75% of 5 times amount, after soaking 2 ~ 3h, insert after juice extractor is squeezed the juice and obtain filtering residue, extruding filtering residue obtains filtrate, filtrate is extracted with supercritical liquid extraction technique, arranging extracting pressure is 30 ~ 45MPa, carbon dioxide is extractant, operative temperature is 26 ~ 35 DEG C, the advantage of the supercritical liquid extraction technique of carbon dioxide is: critical temperature and critical pressure low, operating condition is gentle, few to the destruction of effective ingredient, a kind of and nontoxic like aqueous phase, cheap organic solvent, it is in use stablized, nontoxic, do not burn, safety, free from environmental pollution, and the oxidation of product can be avoided, not containing nitrate and harmful heavy metal in the extract of carbon dioxide, and remaining without hazardous solvent, when supercritical carbon dioxide extraction, the material be extracted is by reducing pressure, or raised temperature can be separated out, need not through extracting operation repeatedly, so supercritical carbon dioxide extraction flow process is simple, be particularly suitable for the Isolation and purification of medicine, the extract obtained filters with microporous membrane filtration again, by filtrate heating recovery ethanol, namely Caulis et Folium Chrysanthemi segeti extract is obtained after cooling,
Step 4: the Lignum Santali Albi extract of extract powder obtained for step one and described composition by weight, Caulis et Folium Chrysanthemi segeti extract are mixed, add the aminomethylbenzoic acid of described composition by weight, lysine, taurine, Zinacef again, be placed in blender with after the rotating speed of 100r/min stirring 25min, be placed in air-stream type ultrafine pulverizer to pulverize, cross 300 mesh sieves, sterilizing is sealed up for safekeeping, namely obtains described for the care drug compositions before surgery anesthesia;
Step 5: after the filler pregelatinized Starch mix homogeneously of the disintegrator carboxymethylstarch sodium and 16 parts that add 10.8 parts in the pharmaceutical composition that step 4 obtains, add 18 parts of binding agent 3 ~ 6% polyvidone alcoholic solution soft materials, cross 20 ~ 30 mesh sieves to granulate, obtain wet soft grit, the soft grit that will wet is dry under 60 DEG C ~ 70 DEG C conditions, make its moisture lower than 3%, obtain dry granule, cross 20 ~ 30 mesh sieves, then add 8.5 parts of lubricant sodium laurylsulfates and 12 parts of micropowder silica gels, after sterilizing, make capsule according to corresponding technique.
The pharmacologically active of the present invention's each medicine raw material is as follows:
Short handle fruits of Celastrus orbiculatus Thunb: [function cures mainly] mind tranquilizing and the heart calming, main insomnia;
Semen Sonchi oleracei: [function cures mainly] goes middle heat, tranquilizing mind;
Fernleaf hedge bamboo: [function cures mainly] qi invigorating and lung moistening, preventing phlegm from forming and stopping coughing, removing toxic substances, main weak after being ill, cough due to lung-heat, phlegm dyspnea gas is stopped up, leucorrhea, toothache caused by fire of deficiency type, venom;
Radix Millettiae typicae: [function cures mainly] dissipating blood stasis, detumescence, pain relieving, allays excitement;
Herba Dichrocephalae auriculatae: [function cures mainly] subsides a swelling, removing toxic substances, diuresis, weak after being ill;
Lignum Poria: [function cures mainly] suppressing the hyperactive liver is calmed the nerves, controls palpitation with fear forgetful, aphasia due to apoplexy, and beriberi is had a cramp;
Fructus Terminaliae Billericae: [function cures mainly] heat-clearing and toxic substances removing, convergence is nourished blood, coordinating the actions of various ingredients in a prescription, for various heat symptom-complex, dysentery, grasserie, liver-gallbladder disease is weak after being ill;
Herba Sedi Aizoon: [function cures mainly] dissipating blood stasis stops blooding, analgesia of calming the nerves.For thrombocytopenic purpura, epistaxis, spits blood, spitting of blood, gingival hemorrhage, digestive tract hemorrhage, metrorrhagia, cardiopalmus, irritated insomnia; Traumatic injury is controlled in external, traumatic hemorrhage, burn and scald;
Rhizoma et radix valerianae: [function cures mainly] controls irritability, and stomach is weak, lumbago, menoxenia, traumatic injury, calmness of calming the nerves, wind dispelling spasmolytic, promoting regeneration of the tissue and arresting bleeding, pain relieving;
Lignum Santali Albi extract: [function cures mainly] normalizing the stomach by guiding QI downward, promoting the circulation of QI to relieve pain, main singultus, vomiting, gastric abscess, lumbago;
Caulis et Folium Chrysanthemi segeti extract: [function cures mainly] and taste, profit two just, drink, gas of feeling at ease by expectorant, and support taste, expectorant is drunk;
Aminomethylbenzoic acid: the activity factor that can suppress plasminogen, make plasminogen can not activate as plasmin, thus suppress fibrinous dissolving, produce anastalsis, mechanism of action is identical with aminocaproic acid, but its effect than strong 4-5 doubly, for hands art, hemorrhage in internal disease caused by hyperfibrinolysis, be applicable to lung, liver, pancreas, prostate, thyroid, the abnormal bleeding during operation such as adrenal gland, department of obstetrics and gynecology and postpartum hemorrhage and hemoptysis of pulmonary tuberculosis, sputum mixed with blood, hematuria, prostate hyperplasia is hemorrhage, upper gastrointestinal hemorrhage etc.,
Lysine: lysine is one of essential amino acid, human development can be promoted, strengthen immunologic function, and be improved the effect of central nervous tissue function, lysine is alkaline essential amino acids, because the lysine content in cereal foods is very low, and be easily destroyed in the course of processing and lack, therefore be called the first limiting amino acids;
Taurine: taurine can suppress platelet aggregation in blood circulation, reduces blood fat, keeps human normal blood pressure and prevents arteriosclerosis, protective effect is had to myocardial cell, can arrhythmia, there is special efficacy to reduction blood cholesterol level, can heart failure be treated;
Zinacef: the treatment being applicable to the infection that sensitive bacterial causes, as lower respiratory infection, upper respiratory tract infection, comprises ear, nose, throat infection, genitourinary tract infections, the diseases such as skin and soft tissue infection.
Compared with prior art, beneficial effect of the present invention is embodied in: the drug effect different according to Chinese medicine and western medicine and the collocation of feature science, suit the remedy to the case, have calm the nerves with all worries set aside, alleviating pain and detumescence, anti-inflammation, hemostasis, strengthen effect of human body immunocompetence and opposing viral infection, the intense strain that effective alleviation patient is preoperative, the psychoreactions such as anxiety and fear, suppress saliva and respiratory secretions, keep airway patency, prevent postoperative pulmonary complications, resist the liquor-saturated complication of poison of some anaesthetic, improve the threshold of pain, wound is had to operate the pain caused before alleviating primary disease or anesthesia, and analgesia effect can be strengthened.It is simple, evident in efficacy that the present invention is used for the care drug compositions preparation technology before surgery anesthesia, and drug effect is gentle, has good medical value.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in more detail:
Embodiment 1: a kind of for the care drug compositions before surgery anesthesia, described pharmaceutical composition is made up of Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients comprises following component: short handle fruits of Celastrus orbiculatus Thunb 35 parts, Semen Sonchi oleracei 32 parts, fernleaf hedge bamboo 29 parts, Radix Millettiae typicae 26 parts, Herba Dichrocephalae auriculatae 24 parts, Lignum Poria 23 parts, Fructus Terminaliae Billericae 19 parts, Herba Sedi Aizoon 18 parts, Rhizoma et radix valerianae 15 parts, Lignum Santali Albi extract 8.2 parts, Caulis et Folium Chrysanthemi segeti extract 6.4 parts; Described western medicine composition comprises following component: aminomethylbenzoic acid 0.15 part, lysine 0.08 part, taurine 0.05 part, Zinacef 0.03 part.
For a preparation method for the care drug compositions before surgery anesthesia, described capsule preparation method thereof comprises the following steps:
Step one: take short handle fruits of Celastrus orbiculatus Thunb according to described part by weight, Semen Sonchi oleracei, fernleaf hedge bamboo, Radix Millettiae typicae, Herba Dichrocephalae auriculatae, Lignum Poria, Fructus Terminaliae Billericae, Herba Sedi Aizoon, Rhizoma et radix valerianae washes with water totally respectively, mixing is placed on oven drying, arranging oven temperature is 60 DEG C, make the moisture of all medical materials lower than 5%, be ground into coarse powder, cross 20 mesh sieves, obtain Chinese medicine mixed powder, the ethanol of the mass concentration 95% of 3 times amount is added in described Chinese medicine mixed powder, after soaking 3h, add the pure water of its 12 times amount again, intense fire boils, then slow fire extracts 2h, filtration obtains filtrate a, give the pure water adding 10 times amount in the medicinal residues after filtering again, intense fire boils, then slow fire extracts 1h, extracting liquid filtering is obtained filtrate b, filtrate a and filtrate b is mixed, after leaving standstill 12h, concentrating under reduced pressure becomes extractum, 120 mesh sieves are crossed after spraying dry, extract powder is made after sterilizing,
Step 2: fresh sandalwood heartwood is cleaned up, the water putting into 5 times amount soaks 10h, the sandalwood heartwood of soaking is inserted in distil container and distills, steam distilling above water is selected to heat, distilling above water distills also known as water proof, refer on the sieve plate that raw material is placed in boiler, certain water yield is held to meet the enough saturated vapors of generation needed for distillation procedure under sieve plate, raw material bottom is not spattered with water for principle when water layer height seethes with excitement with water, distillation starts, first the bottom of a pan water layer is heated, until boiling, the low-pressure saturated steam produced from bottom to top adds thermal material layer by sieve plate, the bed of material forms water oil mixed vapour whole process to pot top is risen up into from saturated vapor, to be slowly advisable, distilling above water raw material only contacts with steam, the low-pressure saturated steam produced, because water capacity is large, be conducive to oil to steam, also be conducive to shortening distillation time, fuel saving, improve the quality of oil yield and oil, filter after obtaining distillate, Oleum Santali albi and Lignum Santali Albi hydrosol is comprised in filtrate, layering is there will be after filtrate being poured into liquid cyclone, namely extract upper strata material obtains as Oleum Santali albi,
Step 3: fresh Caulis et Folium Chrysanthemi segeti is cut into the segment that 2cm is long, add the alcoholic solution of the mass concentration 75% of 5 times amount, after soaking 2h, insert after juice extractor is squeezed the juice and obtain filtering residue, extruding filtering residue obtains filtrate, filtrate is extracted with supercritical liquid extraction technique, arranging extracting pressure is 30MPa, carbon dioxide is extractant, operative temperature is 26 DEG C, the advantage of the supercritical liquid extraction technique of carbon dioxide is: critical temperature and critical pressure low, operating condition is gentle, few to the destruction of effective ingredient, a kind of and nontoxic like aqueous phase, cheap organic solvent, it is in use stablized, nontoxic, do not burn, safety, free from environmental pollution, and the oxidation of product can be avoided, not containing nitrate and harmful heavy metal in the extract of carbon dioxide, and remaining without hazardous solvent, when supercritical carbon dioxide extraction, the material be extracted is by reducing pressure, or raised temperature can be separated out, need not through extracting operation repeatedly, so supercritical carbon dioxide extraction flow process is simple, be particularly suitable for the Isolation and purification of medicine, the extract obtained filters with microporous membrane filtration again, by filtrate heating recovery ethanol, namely Caulis et Folium Chrysanthemi segeti extract is obtained after cooling,
Step 4: the Lignum Santali Albi extract of extract powder obtained for step one and described composition by weight, Caulis et Folium Chrysanthemi segeti extract are mixed, add the aminomethylbenzoic acid of described composition by weight, lysine, taurine, Zinacef again, be placed in blender with after the rotating speed of 100r/min stirring 25min, be placed in air-stream type ultrafine pulverizer to pulverize, cross 300 mesh sieves, sterilizing is sealed up for safekeeping, namely obtains described for the care drug compositions before surgery anesthesia;
Step 5: after the filler pregelatinized Starch mix homogeneously of the disintegrator carboxymethylstarch sodium and 16 parts that add 10.8 parts in the pharmaceutical composition that step 4 obtains, add 18 parts of binding agent 3% polyvidone alcoholic solution soft materials, cross 20 mesh sieves to granulate, obtain wet soft grit, the soft grit that will wet is dry under 60 DEG C of conditions, makes its moisture lower than 3%, obtain dry granule, cross 20 mesh sieves, then add 8.5 parts of lubricant sodium laurylsulfates and 12 parts of micropowder silica gels, after sterilizing, make capsule according to corresponding technique.
Embodiment 2: a kind of for the care drug compositions before surgery anesthesia, described pharmaceutical composition is made up of Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients comprises following component: short handle fruits of Celastrus orbiculatus Thunb 51.5 parts, Semen Sonchi oleracei 46 parts, fernleaf hedge bamboo 43 parts, Radix Millettiae typicae 39 parts, Herba Dichrocephalae auriculatae 37 parts, Lignum Poria 34 parts, Fructus Terminaliae Billericae 31 parts, Herba Sedi Aizoon 26 parts, Rhizoma et radix valerianae 22.5 parts, Lignum Santali Albi extract 9.1 parts, Caulis et Folium Chrysanthemi segeti extract 8.1 parts; Described western medicine composition comprises following component: aminomethylbenzoic acid 0.175 part, lysine 0.11 part, taurine 0.07 part, Zinacef 0.055 part.
For a preparation method for the care drug compositions before surgery anesthesia, described capsule preparation method thereof comprises the following steps:
Step one: take short handle fruits of Celastrus orbiculatus Thunb according to described part by weight, Semen Sonchi oleracei, fernleaf hedge bamboo, Radix Millettiae typicae, Herba Dichrocephalae auriculatae, Lignum Poria, Fructus Terminaliae Billericae, Herba Sedi Aizoon, Rhizoma et radix valerianae washes with water totally respectively, mixing is placed on oven drying, arranging oven temperature is 64 DEG C, make the moisture of all medical materials lower than 5%, be ground into coarse powder, cross 25 mesh sieves, obtain Chinese medicine mixed powder, the ethanol of the mass concentration 95% of 3 times amount is added in described Chinese medicine mixed powder, after soaking 4h, add the pure water of its 13.5 times amount again, intense fire boils, then slow fire extracts 2.5h, filtration obtains filtrate a, give the pure water adding 11 times amount in the medicinal residues after filtering again, intense fire boils, then slow fire extracts 1.5h, extracting liquid filtering is obtained filtrate b, filtrate a and filtrate b is mixed, after leaving standstill 12h, concentrating under reduced pressure becomes extractum, 135 mesh sieves are crossed after spraying dry, extract powder is made after sterilizing,
Step 2: fresh sandalwood heartwood is cleaned up, the water putting into 6.5 times amount soaks 11h, the sandalwood heartwood of soaking is inserted in distil container and distills, steam distilling above water is selected to heat, distilling above water distills also known as water proof, refer on the sieve plate that raw material is placed in boiler, certain water yield is held to meet the enough saturated vapors of generation needed for distillation procedure under sieve plate, raw material bottom is not spattered with water for principle when water layer height seethes with excitement with water, distillation starts, first the bottom of a pan water layer is heated, until boiling, the low-pressure saturated steam produced from bottom to top adds thermal material layer by sieve plate, the bed of material forms water oil mixed vapour whole process to pot top is risen up into from saturated vapor, to be slowly advisable, distilling above water raw material only contacts with steam, the low-pressure saturated steam produced, because water capacity is large, be conducive to oil to steam, also be conducive to shortening distillation time, fuel saving, improve the quality of oil yield and oil, filter after obtaining distillate, Oleum Santali albi and Lignum Santali Albi hydrosol is comprised in filtrate, layering is there will be after filtrate being poured into liquid cyclone, namely extract upper strata material obtains as Oleum Santali albi,
Step 3: fresh Caulis et Folium Chrysanthemi segeti is cut into the segment that 2.5cm is long, add the alcoholic solution of the mass concentration 75% of 5 times amount, after soaking 2.5h, insert after juice extractor is squeezed the juice and obtain filtering residue, extruding filtering residue obtains filtrate, filtrate is extracted with supercritical liquid extraction technique, arranging extracting pressure is 40MPa, carbon dioxide is extractant, operative temperature is 30.5 DEG C, the advantage of the supercritical liquid extraction technique of carbon dioxide is: critical temperature and critical pressure low, operating condition is gentle, few to the destruction of effective ingredient, a kind of and nontoxic like aqueous phase, cheap organic solvent, it is in use stablized, nontoxic, do not burn, safety, free from environmental pollution, and the oxidation of product can be avoided, not containing nitrate and harmful heavy metal in the extract of carbon dioxide, and remaining without hazardous solvent, when supercritical carbon dioxide extraction, the material be extracted is by reducing pressure, or raised temperature can be separated out, need not through extracting operation repeatedly, so supercritical carbon dioxide extraction flow process is simple, be particularly suitable for the Isolation and purification of medicine, the extract obtained filters with microporous membrane filtration again, by filtrate heating recovery ethanol, namely Caulis et Folium Chrysanthemi segeti extract is obtained after cooling,
Step 4: the Lignum Santali Albi extract of extract powder obtained for step one and described composition by weight, Caulis et Folium Chrysanthemi segeti extract are mixed, add the aminomethylbenzoic acid of described composition by weight, lysine, taurine, Zinacef again, be placed in blender with after the rotating speed of 100r/min stirring 25min, be placed in air-stream type ultrafine pulverizer to pulverize, cross 300 mesh sieves, sterilizing is sealed up for safekeeping, namely obtains described for the care drug compositions before surgery anesthesia;
Step 5: after the filler pregelatinized Starch mix homogeneously of the disintegrator carboxymethylstarch sodium and 16 parts that add 10.8 parts in the pharmaceutical composition that step 4 obtains, add 18 parts of binding agent 4.5% polyvidone alcoholic solution soft materials, cross 25 mesh sieves to granulate, obtain wet soft grit, the soft grit that will wet is dry under 65 DEG C of conditions, makes its moisture lower than 3%, obtain dry granule, cross 25 mesh sieves, then add 8.5 parts of lubricant sodium laurylsulfates and 12 parts of micropowder silica gels, after sterilizing, make capsule according to corresponding technique.
Embodiment 3: a kind of for the care drug compositions before surgery anesthesia, described pharmaceutical composition is made up of Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients comprises following component: short handle fruits of Celastrus orbiculatus Thunb 68 parts, Semen Sonchi oleracei 60 parts, fernleaf hedge bamboo 57 parts, Radix Millettiae typicae 52 parts, Herba Dichrocephalae auriculatae 50 parts, Lignum Poria 45 parts, Fructus Terminaliae Billericae 43 parts, Herba Sedi Aizoon 34 parts, Rhizoma et radix valerianae 30 parts, Lignum Santali Albi extract 10 parts, Caulis et Folium Chrysanthemi segeti extract 9.8 parts; Described western medicine composition comprises following component: aminomethylbenzoic acid 0.2 part, lysine 0.14 part, taurine 0.09 part, Zinacef 0.08 part.
For a preparation method for the care drug compositions before surgery anesthesia, described capsule preparation method thereof comprises the following steps:
Step one: take short handle fruits of Celastrus orbiculatus Thunb according to described part by weight, Semen Sonchi oleracei, fernleaf hedge bamboo, Radix Millettiae typicae, Herba Dichrocephalae auriculatae, Lignum Poria, Fructus Terminaliae Billericae, Herba Sedi Aizoon, Rhizoma et radix valerianae washes with water totally respectively, mixing is placed on oven drying, arranging oven temperature is 68 DEG C, make the moisture of all medical materials lower than 5%, be ground into coarse powder, cross 30 mesh sieves, obtain Chinese medicine mixed powder, the ethanol of the mass concentration 95% of 3 times amount is added in described Chinese medicine mixed powder, after soaking 5h, add the pure water of its 15 times amount again, intense fire boils, then slow fire extracts 3h, filtration obtains filtrate a, give the pure water adding 12 times amount in the medicinal residues after filtering again, intense fire boils, then slow fire extracts 2h, extracting liquid filtering is obtained filtrate b, filtrate a and filtrate b is mixed, after leaving standstill 12h, concentrating under reduced pressure becomes extractum, 150 mesh sieves are crossed after spraying dry, extract powder is made after sterilizing,
Step 2: fresh sandalwood heartwood is cleaned up, the water putting into 8 times amount soaks 12h, the sandalwood heartwood of soaking is inserted in distil container and distills, steam distilling above water is selected to heat, distilling above water distills also known as water proof, refer on the sieve plate that raw material is placed in boiler, certain water yield is held to meet the enough saturated vapors of generation needed for distillation procedure under sieve plate, raw material bottom is not spattered with water for principle when water layer height seethes with excitement with water, distillation starts, first the bottom of a pan water layer is heated, until boiling, the low-pressure saturated steam produced from bottom to top adds thermal material layer by sieve plate, the bed of material forms water oil mixed vapour whole process to pot top is risen up into from saturated vapor, to be slowly advisable, distilling above water raw material only contacts with steam, the low-pressure saturated steam produced, because water capacity is large, be conducive to oil to steam, also be conducive to shortening distillation time, fuel saving, improve the quality of oil yield and oil, filter after obtaining distillate, Oleum Santali albi and Lignum Santali Albi hydrosol is comprised in filtrate, layering is there will be after filtrate being poured into liquid cyclone, namely extract upper strata material obtains as Oleum Santali albi,
Step 3: fresh Caulis et Folium Chrysanthemi segeti is cut into the segment that 3cm is long, add the alcoholic solution of the mass concentration 75% of 5 times amount, after soaking 3h, insert after juice extractor is squeezed the juice and obtain filtering residue, extruding filtering residue obtains filtrate, filtrate is extracted with supercritical liquid extraction technique, arranging extracting pressure is 45MPa, carbon dioxide is extractant, operative temperature is 35 DEG C, the advantage of the supercritical liquid extraction technique of carbon dioxide is: critical temperature and critical pressure low, operating condition is gentle, few to the destruction of effective ingredient, a kind of and nontoxic like aqueous phase, cheap organic solvent, it is in use stablized, nontoxic, do not burn, safety, free from environmental pollution, and the oxidation of product can be avoided, not containing nitrate and harmful heavy metal in the extract of carbon dioxide, and remaining without hazardous solvent, when supercritical carbon dioxide extraction, the material be extracted is by reducing pressure, or raised temperature can be separated out, need not through extracting operation repeatedly, so supercritical carbon dioxide extraction flow process is simple, be particularly suitable for the Isolation and purification of medicine, the extract obtained filters with microporous membrane filtration again, by filtrate heating recovery ethanol, namely Caulis et Folium Chrysanthemi segeti extract is obtained after cooling,
Step 4: the Lignum Santali Albi extract of extract powder obtained for step one and described composition by weight, Caulis et Folium Chrysanthemi segeti extract are mixed, add the aminomethylbenzoic acid of described composition by weight, lysine, taurine, Zinacef again, be placed in blender with after the rotating speed of 100r/min stirring 25min, be placed in air-stream type ultrafine pulverizer to pulverize, cross 300 mesh sieves, sterilizing is sealed up for safekeeping, namely obtains described for the care drug compositions before surgery anesthesia;
Step 5: after the filler pregelatinized Starch mix homogeneously of the disintegrator carboxymethylstarch sodium and 16 parts that add 10.8 parts in the pharmaceutical composition that step 4 obtains, add 18 parts of binding agent 6% polyvidone alcoholic solution soft materials, cross 30 mesh sieves to granulate, obtain wet soft grit, the soft grit that will wet is dry under 70 DEG C of conditions, makes its moisture lower than 3%, obtain dry granule, cross 30 mesh sieves, then add 8.5 parts of lubricant sodium laurylsulfates and 12 parts of micropowder silica gels, after sterilizing, make capsule according to corresponding technique.
Clinical trial:
1. clinical case is selected and is divided into groups: inventor collects 150 routine patient with operation altogether, is divided into three groups at random, often organizes 50 people, and the data such as two groups of sexes, age, state of an illness there are no significant difference, has comparability.
2. test method: the capsule taking the embodiment of the present invention 1, embodiment 2, embodiment 3 preparation respectively to test group patient, take 3 every day, 7 days courses for the treatment of, the cycle of taking is different according to different cases.
3. criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
(1) effective: with take patient compared with common drug and be emotionally stable, anaesthesia process is without specific response, and intraoperative blood loss is less than matched group, and the restore cycle is shorter than matched group;
(2) invalid: patient's emotion, anaesthesia process, intraoperative blood loss, restore cycle and take common drug zero difference.
3.2 treatment statistical results
Table 1-tetra-group comparitive study
| The medicine taken | Case number | Effective | Invalid | Untoward reaction | Total effective rate % |
| Embodiment 1 | 50 | 42 | 8 | 0 | 84.0 |
| Embodiment 2 | 50 | 47 | 3 | 0 | 94.0 |
| Embodiment 3 | 50 | 45 | 5 | 0 | 90.0 |
4. conclusion: in clinical trial process, the patient accepting Drug therapy of the present invention finds no any untoward reaction, as seen from the data in Table 1, medicine of the present invention reaches more than 84.0% to the prenarcotic nursing total effective rate of operation, be for surgery anesthesia before nursing safety active drug, there is good clinical meaning.
5. clinical individual case
Case 1: river, man, 18 years old, in chronic appendicitis inadvertent closure, the preoperative capsule three days taken the embodiment of the present invention 1 and prepare, in operation process, the mental status is good, few in intraoperative blood loss compared with normal situation, postoperative continuation takes 4 days, and wound healing is shorter than the normal condition time 3 days.
Case 2: road so-and-so, female, 45 years old, in hysteromyoma operation process, the preoperative capsule 5 days taken the embodiment of the present invention 2 and prepare, in operation process, amount of bleeding reduces, postoperative continuation takes 6 days, and pain compared with normal situation weakens, and the restore cycle is shorter than regular situation one week.
Case 3: Wang, man, 54 years old, need to carry out partial cystectomy because suffering from bladder cancer, the preoperative capsule 5 days taken the embodiment of the present invention 3 and prepare, the intense strain of the front patient of surgery anesthesia takes a turn for the better, anesthesia is very smooth, and postoperative wound pain weakens, and postoperative continuation takes 10 days, do not occur infecting and inflammation, the restore cycle is shorter than normal condition 15 days.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (7)
1. one kind for the care drug compositions before surgery anesthesia, it is characterized in that, described pharmaceutical composition is made up of Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients comprises following component: short handle fruits of Celastrus orbiculatus Thunb 35 ~ 68 parts, Semen Sonchi oleracei 32 ~ 60 parts, fernleaf hedge bamboo 29 ~ 57 parts, Radix Millettiae typicae 26 ~ 52 parts, Herba Dichrocephalae auriculatae 24 ~ 50 parts, Lignum Poria 23 ~ 45 parts, Fructus Terminaliae Billericae 19 ~ 43 parts, Herba Sedi Aizoon 18 ~ 34 parts, Rhizoma et radix valerianae 15 ~ 30 parts, Lignum Santali Albi extract 8.2 ~ 10 parts, Caulis et Folium Chrysanthemi segeti extract 6.4 ~ 9.8 parts; Described western medicine composition comprises following component: aminomethylbenzoic acid 0.15 ~ 0.2 part, lysine 0.08 ~ 0.14 part, taurine 0.05 ~ 0.09 part, Zinacef 0.03 ~ 0.08 part.
2. a kind of for the care drug compositions before surgery anesthesia as claimed in claim 1, it is characterized in that, described pharmaceutical composition is made up of Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients comprises following component: short handle fruits of Celastrus orbiculatus Thunb 51.5 parts, Semen Sonchi oleracei 46 parts, fernleaf hedge bamboo 43 parts, Radix Millettiae typicae 39 parts, Herba Dichrocephalae auriculatae 37 parts, Lignum Poria 34 parts, Fructus Terminaliae Billericae 31 parts, Herba Sedi Aizoon 26 parts, Rhizoma et radix valerianae 22.5 parts, Lignum Santali Albi extract 9.1 parts, Caulis et Folium Chrysanthemi segeti extract 8.1 parts; Described western medicine composition comprises following component: aminomethylbenzoic acid 0.175 part, lysine 0.11 part, taurine 0.07 part, Zinacef 0.055 part.
3. a kind of for the care drug compositions before surgery anesthesia as described in claim 1 ~ 2 any one, it is characterized in that, described Lignum Santali Albi extract is Oleum Santali albi, its preparation method is: fresh sandalwood heartwood cleaned up, the water putting into 5 ~ 8 times amount soaks 10 ~ 12h, the sandalwood heartwood of soaking is inserted in distil container and distills, steam distilling above water is selected to heat, filter after obtaining distillate, Oleum Santali albi and Lignum Santali Albi hydrosol is comprised in filtrate, there will be layering after filtrate being poured into liquid cyclone, extract upper strata material and namely obtain as Oleum Santali albi.
4. a kind of for the care drug compositions before surgery anesthesia as described in claim 1 ~ 2 any one, it is characterized in that, described Caulis et Folium Chrysanthemi segeti method for preparing extractive is: fresh Caulis et Folium Chrysanthemi segeti is cut into the segment that 2 ~ 3cm is long, add the alcoholic solution of the mass concentration 75% of 5 times amount, after soaking 2 ~ 3h, insert after juice extractor is squeezed the juice and obtain filtering residue, extruding filtering residue obtains filtrate, filtrate is extracted with supercritical liquid extraction technique, arranging extracting pressure is 30 ~ 45MPa, carbon dioxide is extractant, operative temperature is 26 ~ 35 DEG C, the extract obtained filters with microporous membrane filtration again, by filtrate heating recovery ethanol, namely Caulis et Folium Chrysanthemi segeti extract is obtained after cooling.
5. a kind of as described in Claims 1 to 4 any one is characterized in that for the care drug compositions before surgery anesthesia, and the preparation method of described pharmaceutical composition is:
Step one: take short handle fruits of Celastrus orbiculatus Thunb according to described part by weight, Semen Sonchi oleracei, fernleaf hedge bamboo, Radix Millettiae typicae, Herba Dichrocephalae auriculatae, Lignum Poria, Fructus Terminaliae Billericae, Herba Sedi Aizoon, Rhizoma et radix valerianae washes with water totally respectively, mixing is placed on oven drying, arranging oven temperature is 60 ~ 68 DEG C, make the moisture of all medical materials lower than 5%, be ground into coarse powder, cross 20 ~ 30 mesh sieves, obtain Chinese medicine mixed powder, the ethanol of the mass concentration 95% of 3 times amount is added in described Chinese medicine mixed powder, after soaking 3 ~ 5h, add the pure water of its 12 ~ 15 times amount again, intense fire boils, then slow fire extracts 2 ~ 3h, filtration obtains filtrate a, give the pure water adding 10 ~ 12 times amount in the medicinal residues after filtering again, intense fire boils, then slow fire extracts 1 ~ 2h, extracting liquid filtering is obtained filtrate b, filtrate a and filtrate b is mixed, after leaving standstill 12h, concentrating under reduced pressure becomes extractum, 120 ~ 150 mesh sieves are crossed after spraying dry, extract powder is made after sterilizing,
Step 2: fresh sandalwood heartwood is cleaned up, the water putting into 5 ~ 8 times amount soaks 10 ~ 12h, the sandalwood heartwood of soaking is inserted in distil container and distills, vapor distillation is selected to heat, filter after obtaining distillate, comprise Oleum Santali albi and Lignum Santali Albi hydrosol in filtrate, after filtrate being poured into liquid cyclone, there will be layering, extract upper strata material and namely obtain as Oleum Santali albi;
Step 3: fresh Caulis et Folium Chrysanthemi segeti is cut into the segment that 2 ~ 3cm is long, add the alcoholic solution of the mass concentration 75% of 5 times amount, after soaking 2 ~ 3h, insert after juice extractor is squeezed the juice and obtain filtering residue, extruding filtering residue obtains filtrate, filtrate extracted with supercritical liquid extraction technique, arranging extracting pressure is 30 ~ 45MPa, and carbon dioxide is extractant, operative temperature is 26 ~ 35 DEG C, the extract obtained filters with microporous membrane filtration again, by filtrate heating recovery ethanol, namely obtains Caulis et Folium Chrysanthemi segeti extract after cooling;
Step 4: the Lignum Santali Albi extract of extract powder obtained for step one and described composition by weight, Caulis et Folium Chrysanthemi segeti extract are mixed; add the aminomethylbenzoic acid of described composition by weight, lysine, taurine, Zinacef again; be placed in blender with after the rotating speed of 100r/min stirring 25min; be placed in air-stream type ultrafine pulverizer to pulverize; cross 300 mesh sieves; sterilizing is sealed up for safekeeping, namely obtains described for the care drug compositions before surgery anesthesia.
6. a kind of preparation method for the care drug compositions before surgery anesthesia as claimed in claim 5, it is characterized in that, described pharmaceutical composition adds required adjuvant can be prepared into capsule.
7. a kind of preparation method for the care drug compositions before surgery anesthesia as claimed in claim 6, it is characterized in that, described capsule preparation method thereof comprises the following steps:
Step one: take short handle fruits of Celastrus orbiculatus Thunb according to described part by weight, Semen Sonchi oleracei, fernleaf hedge bamboo, Radix Millettiae typicae, Herba Dichrocephalae auriculatae, Lignum Poria, Fructus Terminaliae Billericae, Herba Sedi Aizoon, Rhizoma et radix valerianae washes with water totally respectively, mixing is placed on oven drying, arranging oven temperature is 60 ~ 68 DEG C, make the moisture of all medical materials lower than 5%, be ground into coarse powder, cross 20 ~ 30 mesh sieves, obtain Chinese medicine mixed powder, the ethanol of the mass concentration 95% of 3 times amount is added in described Chinese medicine mixed powder, after soaking 3 ~ 5h, add the pure water of its 12 ~ 15 times amount again, intense fire boils, then slow fire extracts 2 ~ 3h, filtration obtains filtrate a, give the pure water adding 10 ~ 12 times amount in the medicinal residues after filtering again, intense fire boils, then slow fire extracts 1 ~ 2h, extracting liquid filtering is obtained filtrate b, filtrate a and filtrate b is mixed, after leaving standstill 12h, concentrating under reduced pressure becomes extractum, 120 ~ 150 mesh sieves are crossed after spraying dry, extract powder is made after sterilizing,
Step 2: fresh sandalwood heartwood is cleaned up, the water putting into 5 ~ 8 times amount soaks 10 ~ 12h, the sandalwood heartwood of soaking is inserted in distil container and distills, steam distilling above water is selected to heat, filter after obtaining distillate, comprise Oleum Santali albi and Lignum Santali Albi hydrosol in filtrate, after filtrate being poured into liquid cyclone, there will be layering, extract upper strata material and namely obtain as Oleum Santali albi;
Step 3: fresh Caulis et Folium Chrysanthemi segeti is cut into the segment that 2 ~ 3cm is long, add the alcoholic solution of the mass concentration 75% of 5 times amount, after soaking 2 ~ 3h, insert after juice extractor is squeezed the juice and obtain filtering residue, extruding filtering residue obtains filtrate, filtrate extracted with supercritical liquid extraction technique, arranging extracting pressure is 30 ~ 45MPa, and carbon dioxide is extractant, operative temperature is 26 ~ 35 DEG C, the extract obtained filters with microporous membrane filtration again, by filtrate heating recovery ethanol, namely obtains Caulis et Folium Chrysanthemi segeti extract after cooling;
Step 4: the Lignum Santali Albi extract of extract powder obtained for step one and described composition by weight, Caulis et Folium Chrysanthemi segeti extract are mixed, add the aminomethylbenzoic acid of described composition by weight, lysine, taurine, Zinacef again, be placed in blender with after the rotating speed of 100r/min stirring 25min, be placed in air-stream type ultrafine pulverizer to pulverize, cross 300 mesh sieves, sterilizing is sealed up for safekeeping, namely obtains described for the care drug compositions before surgery anesthesia;
Step 5: after the filler pregelatinized Starch mix homogeneously of the disintegrator carboxymethylstarch sodium and 16 parts that add 10.8 parts in the pharmaceutical composition that step 4 obtains, add 18 parts of binding agent soft materials, cross 20 ~ 30 mesh sieves to granulate, obtain wet soft grit, the soft grit that will wet is dry under 60 DEG C ~ 70 DEG C conditions, makes its moisture lower than 3%, obtain dry granule, cross 20 ~ 30 mesh sieves, then add 8.5 parts of lubricant sodium laurylsulfates and 12 parts of micropowder silica gels, after sterilizing, make capsule according to corresponding technique.
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| CN103721189A (en) * | 2013-12-27 | 2014-04-16 | 刘玉含 | Meningeoma nursing medicine and preparation method thereof |
-
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- 2016-01-11 CN CN201610015724.2A patent/CN105535489A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103721189A (en) * | 2013-12-27 | 2014-04-16 | 刘玉含 | Meningeoma nursing medicine and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 徐燕等: "《现代护理学》", 31 January 2015, 人民军医出版社 * |
| 王莲芳: "《常见肿瘤疾病的诊疗与护理》", 30 April 2013, 科学技术文献出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109985113A (en) * | 2018-01-02 | 2019-07-09 | 李康 | Borneol health care essential oil and preparation method thereof |
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