CN105311473A

CN105311473A - Rapid hemostasis drug

Info

Publication number: CN105311473A
Application number: CN201510837331.5A
Authority: CN
Inventors: 黄凤玲
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-11-27
Filing date: 2015-11-27
Publication date: 2016-02-10

Abstract

The invention provides a rapid hemostasis drug. The rapid hemostasis drug is prepared from, by weight, 10-20 parts of panax notoginseng, 10-20 parts of folium artemisiae argyi, 10-20 parts of hematoxylon, 10-20 parts of schizocapsa leaves, 10-20 parts of honeysuckle flowers, 10-20 parts of radix scutellariae, 10-20 parts of sambucus williamsii, 5-15 parts of saposhnicovia divaricata, 5-15 parts of Chinese brake herbs, 5-15 parts of honeysuckle stems, 5-15 parts of bletilla striata, 5-15 parts of sanguisorba officinalis, 5-15 parts of rhizoma imperatae, 5-15 parts of rubia cordifolia, 5-15 parts of agrimonia pilosa ledeb, 5-15 parts of radix geutianae, 5-15 parts of dragon bones, 5-15 parts of aloe, 1-5 parts of euphorbia humifusa, 1-5 parts of cortex moutan, 1-5 parts of hydnocarpus anthelmintica Pier. and 1-5 parts of radix phytolaccae. The rapid hemostasis drug has the advantages of being few in toxic and side effects, rapid in hemostasis, capable of promoting wound healing and the like.

Description

The medicine of quick-acting haemostatic powder

Technical field

The present invention relates to a kind of medicine of quick-acting haemostatic powder, belong to technical field of Chinese medicines.

Background technology

Wound hemorrhage is disease the most common in daily life, so wound hemostasis, is in medical industry naturally and the focus of medical circle research.Conventional at present hemostatic material such as collagen protein sponge, gelfoam, regenerated fiber hemostatic gauze etc. have been applied for many years clinical, but different materials has different hemostatic mechanisms and corresponding advantage and limitation, and especially pure Animal by-product has higher risk.And these materials mainly stop blooding use, can not play disinfecting pain relieving and promote the effect of wound healing, thus the scope of application is greatly limited.

Summary of the invention

The technical problem to be solved in the present invention is: the medicine providing a kind of quick-acting haemostatic powder, has that toxic and side effects is little, hemostasis is fast and can promote the advantages such as wound healing.

For solving the problems of the technologies described above, the present invention by the following technical solutions:

The medicine of quick-acting haemostatic powder, is obtained by the raw material of following weight parts:

Radix Notoginseng 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Lignum Sappan 10 ~ 20 parts, Folium Taccae plantagineae 10 ~ 20 parts, Flos Lonicerae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Ramulus Sambuci Williamsii 10 ~ 20 parts, Radix Saposhnikoviae 5 ~ 15 parts, Herba Pteridis Multifidae 5 ~ 15 parts, Caulis Lonicerae 5 ~ 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 ~ 15 parts, Radix Sanguisorbae 5 ~ 15 parts, Rhizoma Imperatae 5 ~ 15 parts, 5 ~ 15 parts, Radix Rubiae, Herba Agrimoniae 5 ~ 15 parts, Radix Gentianae 5 ~ 15 parts, Os Draconis 5 ~ 15 parts, Aloe 5 ~ 15 parts, Herba Euphorbiae Humifusae 1 ~ 5 part, Cortex Moutan 1 ~ 5 part, Semen Hydnocarpi 1 ~ 5 part, Radix Phytolaccae 1 ~ 5 part.

As preferably, provide a concrete formula here, the weight portion of described raw material is:

Radix Notoginseng 20 parts, Folium Artemisiae Argyi 10 parts, Lignum Sappan 15 parts, Folium Taccae plantagineae 20 parts, Flos Lonicerae 10 parts, Radix Scutellariae 15 parts, Ramulus Sambuci Williamsii 20 parts, Radix Saposhnikoviae 5 parts, Herba Pteridis Multifidae 9 parts, Caulis Lonicerae 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Radix Sanguisorbae 12 parts, Rhizoma Imperatae 15 parts, 5 parts, Radix Rubiae, Herba Agrimoniae 8 parts, Radix Gentianae 15 parts, Os Draconis 5 parts, Aloe 9 parts, Herba Euphorbiae Humifusae 5 parts, Cortex Moutan 1 part, Semen Hydnocarpi 2 parts, Radix Phytolaccae 4 parts.

As preferably, provide second concrete formula here, the weight portion of described raw material is:

Radix Notoginseng 10 parts, Folium Artemisiae Argyi 15 parts, Lignum Sappan 20 parts, Folium Taccae plantagineae 10 parts, Flos Lonicerae 15 parts, Radix Scutellariae 20 parts, Ramulus Sambuci Williamsii 10 parts, Radix Saposhnikoviae 10 parts, Herba Pteridis Multifidae 15 parts, Caulis Lonicerae 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Radix Sanguisorbae 15 parts, Rhizoma Imperatae 5 parts, 10 parts, Radix Rubiae, Herba Agrimoniae 15 parts, Radix Gentianae 5 parts, Os Draconis 10 parts, Aloe 15 parts, Herba Euphorbiae Humifusae 1 part, Cortex Moutan 3 parts, Semen Hydnocarpi 5 parts, Radix Phytolaccae 1 part.

As preferably, provide the 3rd concrete formula here, the weight portion of described raw material is:

Radix Notoginseng 15 parts, Folium Artemisiae Argyi 20 parts, Lignum Sappan 10 parts, Folium Taccae plantagineae 15 parts, Flos Lonicerae 20 parts, Radix Scutellariae 10 parts, Ramulus Sambuci Williamsii 15 parts, Radix Saposhnikoviae 15 parts, Herba Pteridis Multifidae 5 parts, Caulis Lonicerae 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Radix Sanguisorbae 5 parts, Rhizoma Imperatae 10 parts, 15 parts, Radix Rubiae, Herba Agrimoniae 5 parts, Radix Gentianae 10 parts, Os Draconis 15 parts, Aloe 5 parts, Herba Euphorbiae Humifusae 2 parts, Cortex Moutan 5 parts, Semen Hydnocarpi 1 part, Radix Phytolaccae 3 parts.

The present invention also provides the preparation method of said medicine, its step the following is: by raw material with the hot-water soak of 80 ~ 90 DEG C after 30 ~ 90 minutes, taking-up drains, then be placed in 200 ~ 230 DEG C of hot pots to stir-fry 10 ~ 20 minutes, then after adding the Oleum Cocois of its weight 1% ~ 3%, continue to stir-fry 10 ~ 20 minutes, after taking out cooling, with all the other raw material co-grinding to 80 ~ 100 orders, after sterilization, namely obtain this medicine.

The using method of this medicine is: by uniform application in affected part, and dosage, for be no more than 5 grams at every turn, effectively can realize microtrauma hemostasis.

The invention has the beneficial effects as follows: raw material of the present invention is conventional Chinese herbal medicine, wide material sources, low price; Pharmaceutical formulation is scientific and reasonable, synergism between each component, can effectively inhibiting bacteria and diminishing inflammation, promotion wound blood condense and promote the growth of new skin; Through the use of clinical 100 patients, effective gross hemostasis rate effective percentage reaches 99%, does not find toxic and side effects case, wherein, namely can effective healing of wound in the patient of 85% one week, thus this medicine has the feature of good effect, instant effect.

Detailed description of the invention

Further illustrate the present invention by the following examples, but the invention is not restricted to these embodiments.

Embodiment 1

The medicine of quick-acting haemostatic powder, is obtained by the raw material of following weight parts: Radix Notoginseng 20 parts, Folium Artemisiae Argyi 10 parts, Lignum Sappan 15 parts, Folium Taccae plantagineae 20 parts, Flos Lonicerae 10 parts, Radix Scutellariae 15 parts, Ramulus Sambuci Williamsii 20 parts, Radix Saposhnikoviae 5 parts, Herba Pteridis Multifidae 9 parts, Caulis Lonicerae 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Radix Sanguisorbae 12 parts, Rhizoma Imperatae 15 parts, 5 parts, Radix Rubiae, Herba Agrimoniae 8 parts, Radix Gentianae 15 parts, Os Draconis 5 parts, Aloe 9 parts, Herba Euphorbiae Humifusae 5 parts, Cortex Moutan 1 part, Semen Hydnocarpi 2 parts, Radix Phytolaccae 4 parts.

The preparation method of medicine is: by raw material with the hot-water soak of 80 DEG C after 60 minutes, taking-up drains, then be placed in 200 ~ 230 DEG C of hot pots to stir-fry 20 minutes, then after adding the Oleum Cocois of its weight 1%, continue to stir-fry 20 minutes, after taking out cooling, with all the other raw material co-grinding to 80 orders, after sterilization, namely obtain this medicine.

Embodiment 2

The medicine of quick-acting haemostatic powder, is obtained by the raw material of following weight parts: Radix Notoginseng 10 parts, Folium Artemisiae Argyi 15 parts, Lignum Sappan 20 parts, Folium Taccae plantagineae 10 parts, Flos Lonicerae 15 parts, Radix Scutellariae 20 parts, Ramulus Sambuci Williamsii 10 parts, Radix Saposhnikoviae 10 parts, Herba Pteridis Multifidae 15 parts, Caulis Lonicerae 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Radix Sanguisorbae 15 parts, Rhizoma Imperatae 5 parts, 10 parts, Radix Rubiae, Herba Agrimoniae 15 parts, Radix Gentianae 5 parts, Os Draconis 10 parts, Aloe 15 parts, Herba Euphorbiae Humifusae 1 part, Cortex Moutan 3 parts, Semen Hydnocarpi 5 parts, Radix Phytolaccae 1 part.

The preparation method of medicine is: by raw material with the hot-water soak of 85 DEG C after 90 minutes, taking-up drains, then be placed in 200 ~ 230 DEG C of hot pots to stir-fry 10 minutes, then after adding the Oleum Cocois of its weight 3%, continue to stir-fry 10 minutes, after taking out cooling, with all the other raw material co-grinding to 100 orders, after sterilization, namely obtain this medicine.

Embodiment 3

The medicine of quick-acting haemostatic powder, is obtained by the raw material of following weight parts: Radix Notoginseng 15 parts, Folium Artemisiae Argyi 20 parts, Lignum Sappan 10 parts, Folium Taccae plantagineae 15 parts, Flos Lonicerae 20 parts, Radix Scutellariae 10 parts, Ramulus Sambuci Williamsii 15 parts, Radix Saposhnikoviae 15 parts, Herba Pteridis Multifidae 5 parts, Caulis Lonicerae 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Radix Sanguisorbae 5 parts, Rhizoma Imperatae 10 parts, 15 parts, Radix Rubiae, Herba Agrimoniae 5 parts, Radix Gentianae 10 parts, Os Draconis 15 parts, Aloe 5 parts, Herba Euphorbiae Humifusae 2 parts, Cortex Moutan 5 parts, Semen Hydnocarpi 1 part, Radix Phytolaccae 3 parts.

The preparation method of medicine is: by raw material with the hot-water soak of 90 DEG C after 30 minutes, taking-up drains, then be placed in 200 ~ 230 DEG C of hot pots to stir-fry 15 minutes, then after adding the Oleum Cocois of its weight 2%, continue to stir-fry 15 minutes, after taking out cooling, with all the other raw material co-grinding to 90 orders, after sterilization, namely obtain this medicine.

Toxicity test

Get ICR mice, before experiment, water 15h is can't help in fasting, is divided into 19 groups (the trial drug group of each embodiment 6 groups, matched groups 1 group).Each group of mouse tail vein administration, test 1 group and be all according to dosage respectively 500mg/kg, 1000mg/kg, 2000mg/kg, 5000mg/kg, 10000mg/kg, 20000mg/kg to test 6 groups of dosages, control group mice gives same volume distilled water.Examine and record administration at once to toxic reaction and the death condition of mice appearance in 7d; Bliss ' s method is adopted to calculate LD50.The following form of experimental result:

Group	mg/kg
		Embodiment 1 medicine	5938.93
Embodiment 2 medicine	5885.29
		Embodiment 3 medicine	5870.05

The LD50 of medicine is at more than 5870mg/kg as seen from the above table, and obviously the toxicity of this medicine is very low, in the rational scope of application, few to the toxic and side effects of human body.

Claims

1. the medicine of quick-acting haemostatic powder, it is characterized in that, obtained by the raw material of following weight parts: Radix Notoginseng 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Lignum Sappan 10 ~ 20 parts, Folium Taccae plantagineae 10 ~ 20 parts, Flos Lonicerae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Ramulus Sambuci Williamsii 10 ~ 20 parts, Radix Saposhnikoviae 5 ~ 15 parts, Herba Pteridis Multifidae 5 ~ 15 parts, Caulis Lonicerae 5 ~ 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 ~ 15 parts, Radix Sanguisorbae 5 ~ 15 parts, Rhizoma Imperatae 5 ~ 15 parts, 5 ~ 15 parts, Radix Rubiae, Herba Agrimoniae 5 ~ 15 parts, Radix Gentianae 5 ~ 15 parts, Os Draconis 5 ~ 15 parts, Aloe 5 ~ 15 parts, Herba Euphorbiae Humifusae 1 ~ 5 part, Cortex Moutan 1 ~ 5 part, Semen Hydnocarpi 1 ~ 5 part, Radix Phytolaccae 1 ~ 5 part.

2. medicine according to claim 1, it is characterized in that, the weight portion of described raw material is: Radix Notoginseng 20 parts, Folium Artemisiae Argyi 10 parts, Lignum Sappan 15 parts, Folium Taccae plantagineae 20 parts, Flos Lonicerae 10 parts, Radix Scutellariae 15 parts, Ramulus Sambuci Williamsii 20 parts, Radix Saposhnikoviae 5 parts, Herba Pteridis Multifidae 9 parts, Caulis Lonicerae 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Radix Sanguisorbae 12 parts, Rhizoma Imperatae 15 parts, 5 parts, Radix Rubiae, Herba Agrimoniae 8 parts, Radix Gentianae 15 parts, Os Draconis 5 parts, Aloe 9 parts, Herba Euphorbiae Humifusae 5 parts, Cortex Moutan 1 part, Semen Hydnocarpi 2 parts, Radix Phytolaccae 4 parts.

3. medicine according to claim 1, it is characterized in that, the weight portion of described raw material is: Radix Notoginseng 10 parts, Folium Artemisiae Argyi 15 parts, Lignum Sappan 20 parts, Folium Taccae plantagineae 10 parts, Flos Lonicerae 15 parts, Radix Scutellariae 20 parts, Ramulus Sambuci Williamsii 10 parts, Radix Saposhnikoviae 10 parts, Herba Pteridis Multifidae 15 parts, Caulis Lonicerae 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Radix Sanguisorbae 15 parts, Rhizoma Imperatae 5 parts, 10 parts, Radix Rubiae, Herba Agrimoniae 15 parts, Radix Gentianae 5 parts, Os Draconis 10 parts, Aloe 15 parts, Herba Euphorbiae Humifusae 1 part, Cortex Moutan 3 parts, Semen Hydnocarpi 5 parts, Radix Phytolaccae 1 part.

4. medicine according to claim 1, it is characterized in that, the weight portion of described raw material is: Radix Notoginseng 15 parts, Folium Artemisiae Argyi 20 parts, Lignum Sappan 10 parts, Folium Taccae plantagineae 15 parts, Flos Lonicerae 20 parts, Radix Scutellariae 10 parts, Ramulus Sambuci Williamsii 15 parts, Radix Saposhnikoviae 15 parts, Herba Pteridis Multifidae 5 parts, Caulis Lonicerae 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Radix Sanguisorbae 5 parts, Rhizoma Imperatae 10 parts, 15 parts, Radix Rubiae, Herba Agrimoniae 5 parts, Radix Gentianae 10 parts, Os Draconis 15 parts, Aloe 5 parts, Herba Euphorbiae Humifusae 2 parts, Cortex Moutan 5 parts, Semen Hydnocarpi 1 part, Radix Phytolaccae 3 parts.

5. the medicine according to any one of Claims 1 to 4, it is characterized in that, the preparation method of medicine is: by raw material with the hot-water soak of 80 ~ 90 DEG C after 30 ~ 90 minutes, taking-up drains, and is then placed in 200 ~ 230 DEG C of hot pots and stir-fries 10 ~ 20 minutes, after then adding the Oleum Cocois of its weight 1% ~ 3%, continue to stir-fry 10 ~ 20 minutes, after taking out cooling, with all the other raw material co-grinding to 80 ~ 100 orders, after sterilization, namely obtain this medicine.