CN105267435A - Freckle-removing anti-aging compound Sanqie tablet and its preparation method and application - Google Patents
Freckle-removing anti-aging compound Sanqie tablet and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a freckle-removing anti-aging compound Sanqie tablet and its preparation method and application. The compound Sanqie tablet is mainly made from following materials by weight: eggplant powder 10-20 parts, tomato powder 10-20 parts, Pyracantha fortuneana fruit powder 10-20 parts, red date powder 10-20 parts, Fructus Lycii powder 0.5-1 part, Radix Codonopsis powder 0.5-1 part, and Semen Persicae powder 0.5-1 part. The advantages in the three treasures of Solanaceae are combined with those in Pyracantha fortuneana fruit, red dates, Radix Codonopsis and Semen Persicae to give the feature to the compound Sanqie tablet, the compound Sanqie tablet has the functions such as reducing skin melanin generation and deposition, improving skin blood circulation, removing free radicals, resisting oxidation, adjusting internal secretion, wetting intestines to relax the bowels and improving immunity, has the effects such as significantly removing speckles and improving skin color, is applicable to controlling skin dark specks caused by hyperpigmentation skin diseases such as lentigo, chloasma and sunburn, is also applicable to age defying and the like and has significant effect and no any toxic or side effect.
Description
Technical field
The present invention relates to Chinese medicine whitening formulation art.More particularly, compound recipe three eggplant sheet that the present invention relates to a kind of speckle removing, antisenescence and preparation method thereof and application.
Background technology
Chromatopathy such as freckle (heritability), chloasma (incretion), sunburn (struvite), riehl's melanosis (metabolic) etc. are due to the impact by the factors such as ultraviolet, heredity, endocrine, inflammatory mediator, improper diet because affecting attractive in appearance, Melanin Metabolism is abnormal, the black pigment of skin excessively rapid growth and skewness, local skin will be caused to cross black and pigmentation, show as pigmentation etc. after chloasma, freckle and inflammation.
Plant of Solanaceae Fructus Solani melongenae is one of bluish violet vegetable few in number, containing a large amount of polyphenol in the crust of Fructus Solani melongenae, polyphenol is a kind of antioxidant, there is the effect eliminated harmful free radicals, enhancing body resistance and immunity, resist cancer, melanic deposition can be reduced simultaneously, have significant effect to speckle dispelling.The crust of Fructus Solani melongenae contains more nutrition and dietary fiber than the sarcocarp of the inside, can protect eyes and vision, prevent constipation, prevent cardiovascular and cerebrovascular disease etc., can also reduce hypertension.Also containing abundant vitamin p (bioflavonoids) in Fructus Solani melongenae, this material can strengthen the intercellular adhesion strength of human body, strengthens the elasticity of blood capillary, prevents angiorrhexis hemorrhage.Be that cardiovascular keeps normal function, therefore often eat Fructus Solani melongenae and also can protect cardiovascular and ascorbic acid.
Lycopene is a naturally occurring Carotenoids in plant of Solanaceae tomato plants fruit, and carotenoids material is all important antioxidant, but lycopene is different from beta-carotene and phylloxanthin in many aspects.Lycopene (molecular formula C
40h
56) be a kind of carotenoid pigment of bright redness, also have in other red fruit is as Citrullus vulgaris and Citrua paradiai.Lycopene is one of the most common and the strongest carotenoid antioxygen agent of human body.
Fructus Lycii is the mature fruit of matrimony vine of solanaceae plant; main component lycium barbarum polysaccharide, betanin, wolfberry pigment and ferrum, phosphorus, calcium etc., have tonify deficiency to calm the nerves, improving eyesight dispeled the wind, nourishing kidney lung moistening, promoting immunity, defying age, antitumor, scavenging free radicals, resisting fatigue, radioprotective, protect the liver, reproductive function protection and the effect such as improvement.Because of the merit that it has improving eyesight, be commonly called as " bright eye ".Fructus Lycii is from the Book of Songs " combines in luxuriant Qi ", and just for medicine, the history in existing more than 3000 years so far, the name of Fructus Lycii, first appeared in Shennong's Herbal, is classified as top grade.
Fire sour jujube is Rosaceae Pyracantha plant, and have another name called Fortune Firethorn Fruit, help grain, torch fruit, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), firethorn fruit contains abundant organic acid, protein, aminoacid, vitamin and multiple mineral element, can eat raw, also can be processed into various beverage.Its root bark, peel of stem, fruit, containing abundant tannin, can be used to extract tanning material.Fire sour jujube root can be used as medicine, and its nature and flavor are pained, the effect such as have antidiarrheal, dissipating blood stasis, help digestion, and fruit, leaf, peel of stem be the similar drug effect of tool also.Fire sour jujube leaves can tea making, has heat-clearing and toxic substances removing, the effect of promoting the production of body fluid to quench thirst, astringing to arrest diarrhea.Firethorn fruit extract has obvious inhibitory action to tyrosinase activity, significantly can reduce the content of mice B16 intracellular melanin.In addition, firethorn fruit extract is dose-dependent inhibition effect to Compound48/80 stimulation in rats peritoneal cavity mast cells release histamine.
Fructus Jujubae is all on the books at successive dynasties medicine nationalitys such as Shennong's Herbals, and Fructus Jujubae is all regarded as important tonic so far, Li Shizhen (1518-1593 A.D.) Compendium of Material Medica: Fructus Jujubae sweet in the mouth, warm in nature, and invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid, be used for the treatment of " insufficiency of the spleen weak, anorexia and loose stool, deficiency of qi and blood " etc.The laudatory title that it has " natural complex ball ".Normal food Fructus Jujubae can treat physical weakness, neurasthenia, incoordination between the spleen and stomach, dyspepsia, epersalgia cough, anemia are become thin, and nourishing the liver preventing cancer function is especially outstanding, has saying of " solar eclipse three Fructus Jujubaes, at the age of one hundred years old bear one's age well ".
Radix Codonopsis is traditional tonic that China commonly uses, and main component is lobetyolin, atractyloide III, tangshenoside IV, ligustrin, vanillic acid etc., has invigorating the spleen and replenishing QI, spleen invigorating lung benefiting effect.Modern study confirms that Radix Codonopsis has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation, strengthens hemopoietic function, improves superoxide dismutase activity, strengthens effects such as eliminating free radical ability, Gastrointestinal motility adjustment.In addition castering action is had to the leukopenia that chemotherapy radiotherapy causes.Be applicable to deficiency of the spleen and lung, the cough of cardiopalmus of breathing hard, anorexia and loose stool, ulcer, anemia, dyspnea due to deficiency, interior-heat such as to quench one's thirst at the disease.
Semen Persicae is the dry mature seed of rosaceous plant Fructus Persicae Prunuspersica (L.) Batsch or Prunus davidiana Prunusavidiana (Carr.) Franch., has blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, effect of relieving cough and asthma.For amenorrhea dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, lung abscess acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.
Chinese medicine is mainly enriched blood as the whitening mechanism of whitening agent, invigorate blood circulation, tyrosinase activity suppression, antioxidation, adjustment endocrine, strengthen immunity etc., but the oral whitening preparation research of herbal mixture playing multipath synergistic mechanism at present still belongs to shortage with application, on market, the herbal mixture oral preparations of existing whitening and speckle dispelling is less, and action pathway unification, effect is undesirable, and some toxic and side effects are larger or more.
Summary of the invention
An object of the present invention is to solve at least the problems referred to above, and the advantage will illustrated at least is below provided.
A further object of the invention compound recipe three eggplant sheet being to provide a kind of speckle removing, antisenescence and preparation method thereof and application.This compound recipe three eggplant sheet is by Solanaceae three essentials-essence and pyracantha fortuneana, Fructus Jujubae, the advantage of Radix Codonopsis and Semen Persicae combines, form characteristic, have and reduce dermal melanin generation and deposition, improve cutaneous circulation, scavenging free radicals, antioxidation, adjustment endocrine, loosening bowel to relieve constipation and enhancing immunity wait effect, play remarkable speckle dispelling and improve colour of skin effect, can be used for control passeris montani saturati speckle, chloasma, the skin skin dark stain that the chromatopathys such as sunburn cause, also can be used for defying age, anti-cancer, vision protection, prevent sclerosis of blood vessels and break, hypertension, coronary heart disease, purpura hemorrhagica and constipation etc., and it is without any side effects.
In order to realize according to these objects of the present invention and other advantage, provide a kind of compound recipe three eggplant sheet of speckle removing, antisenescence, obtain primarily of following raw material by weight: Fructus Solani melongenae powder 10-20 part, tomato meal 10-20 part, pyracantha fortuneana powder 10-20 part, red date powder 10-20 part, medlar powder 0.5-1 part, Radix Codonopsis powder 0.5-1 part and peach kernel powder 0.5-1 part.
Preferably, the compound recipe three eggplant sheet of described speckle removing, antisenescence, described Fructus Solani melongenae powder, tomato meal, pyracantha fortuneana powder, red date powder, medlar powder, Radix Codonopsis powder and peach kernel powder, its be respectively by Fructus Solani melongenae, Fructus Lycopersici esculenti, pyracantha fortuneana, Fructus Jujubae, Fructus Lycii, Radix Codonopsis and Semen Persicae through cleaning, after drying, be crushed to 80-100 order, obtained.
A preparation method for the compound recipe three eggplant sheet of speckle removing, antisenescence, comprises the steps:
Step one: the described Fructus Solani melongenae powder of above-mentioned weight portion, tomato meal, pyracantha fortuneana powder, red date powder, medlar powder and Radix Codonopsis powder are fully mixed, obtains mixed powder;
Step 2, the ethanol of 10-20 times adding its weight in described mixed powder carry out alcohol extraction, filter, obtain the first filtrate and the first filtering residue;
Step 3, the water adding 10-20 doubly described mixed powder weight in described first filtering residue carry out water extraction, filter, obtain the second filtrate and the second filtering residue;
Step 4, described first filtrate and described second filtrate to be merged, and carry out concentrated and spraying dry, obtain extract powder;
Step 5: by the peach kernel powder of described extract powder, above-mentioned weight portion and adjuvant mixing, through pelletize, tabletting, obtain described compound recipe three eggplant sheet.
Preferably, the preparation method of the compound recipe three eggplant sheet of described speckle removing, antisenescence, in described step 2, described alcohol extraction refers to that by volume fraction be the ethanol of 50%-95%, reflux, extract, 2 times at 70-80 DEG C, each 1h.
Preferably, the preparation method of the compound recipe three eggplant sheet of described speckle removing, antisenescence, in described step 2, described alcohol extraction refers to that by volume fraction be the ethanol of 50%-95%, and ultrasonic assistant extracts 1-3 time, each 0.5h.
Preferably, the preparation method of the compound recipe three eggplant sheet of described speckle removing, antisenescence, in described step 3, described water extraction refers to described first filtering residue and water reflux, extract, 2 times at 70-80 DEG C, each 1h.
Preferably, the preparation method of the compound recipe three eggplant sheet of described speckle removing, antisenescence, described compound recipe three eggplant sheet, it comprises Sugarless type compound recipe three eggplant sheet, compound recipe three eggplant buccal tablet and compound recipe three eggplant slow release long-acting sheet.
An application for the compound recipe three eggplant sheet of speckle removing, antisenescence, skin skin dark stain, skin whitening and defying age that described compound recipe three eggplant sheet causes for preventing and treating chromatopathy.
Preferably, the application of the compound recipe three eggplant sheet of described speckle removing, antisenescence, described compound recipe three eggplant sheet is used for preventing and treating freckle, chloasma and sunburn.
The present invention at least comprises following beneficial effect:
The first, Fructus Solani melongenae, Fructus Lycopersici esculenti, Fructus Lycii are referred to as Solanaceae three essentials-essence, the advantage of Solanaceae three essentials-essence with pyracantha fortuneana, Fructus Jujubae, Radix Codonopsis, Semen Persicae is combined by the present invention, form characteristic, product is rich in polysaccharide, polyphenol, flavone, glycosides, organic acid, alkaloid, protein, aminoacid, unsaturated fatty acid, multivitamin (C, E, P, riboflavin, thiamine, carotene, nicotinic acid etc.) and various trace elements (Ca, Fe, Zn, P etc.).This is not only conducive to body health, is also conducive to improving the colour of skin or the colour of skin of keeping fit.
The second, compound recipe three eggplant sheet of the present invention, active by restraint of tyrosinase, obviously reduce melanin and generate and deposition; Protection blood vessel wall and elasticity thereof, improve abnormal hemorheology, improve skin microcirculation, increases the erythrocyte number of unit skin, oxygenated haemoglobin quantity and red pigments content, promotes melanin catabolism; Improve body superoxide dismutase (SOD) active, remove unnecessary superoxide radical, antioxidation, prevent skin collagen to be oxidized and cause colour of skin flavescence; Kidney tonifying, essence replenishing, the short sun of YIN nourishing, adjustment endocrine, effectively changes the obvious relaxation phenomenon and endocrine senile symptom that are present in the different link different levels of hypothalamic-pituitary-target gland axis; Loosening bowel to relieve constipation, accelerates poisonous substance in body purged body; Enhancing body resistance and immunity, promote that phagocyte engulfs the foreign bodies such as melanin; The multipaths such as soften cuticle and multi-functional synergistic mechanism, people's complexion is made to turn ruddy, improve the colour of skin, for speckle dispelling, skin whitening, also can be used for defying age, anti-cancer, vision protection, prevention sclerosis of blood vessels and break, hypertension, coronary heart disease, purpura hemorrhagica, constipation etc.;
Three, the present invention gives full play to China's characteristic resources advantage, cohesion elite, the advanced environmental protection of technique, quality controllable stable, definite ingredients, dosage is accurate, effect is definite, and effect is comparatively strong, and range of application is wider, without any side effects, fool proof, taking convenience simultaneously, can swallow, chew, containing sucking or taking with after aqueous dispersion, Social Agree is higher, is another new selection of modern civilization society vast like to be beautiful personage's skin protection and maintaining healthy, will obtains considerable economic benefit and social benefit.
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, can implement according to this with reference to description word to make those skilled in the art.
It should be noted that experimental technique described in following embodiment if no special instructions, is conventional method, described reagent and material, if no special instructions, all can obtain from commercial channels.
Embodiment 1:
Respectively by Fructus Solani melongenae, Fructus Lycopersici esculenti, pyracantha fortuneana, Fructus Jujubae, Fructus Lycii, Radix Codonopsis and Semen Persicae through cleaning, after drying, be crushed to 80 orders, for subsequent use;
Get 10 weight portion Fructus Solani melongenae powder, 10 weight portion tomato meals, 10 weight portion pyracantha fortuneana powder, 10 weight portion red date powders, 0.5 weight portion medlar powder and 0.5 weight portion Radix Codonopsis powder fully to mix, obtain mixed powder;
The volume fraction adding 10 times of its weight in described mixed powder is ethanol reflux, extract, 2 times at 70 DEG C of 70%, and each 1h, filters, obtain the first filtrate and the first filtering residue;
The water adding 10 times of described mixed powder weight in described first filtering residue reflux, extract, 2 times at 70 DEG C, each 1h, filters, obtains the second filtrate and the second filtering residue;
Described first filtrate and described second filtrate are merged, also concentrated through 60-70 DEG C of decompression recycling ethanol, spraying dry, obtains extract powder;
By described extract powder and the mixing of 0.5 weight portion peach kernel powder, adding the mixing of appropriate excipient, is that 95% ethanol or starch slurry are for binding agent with volume fraction, make soft material, granulate with 14 orders, 12 order granulate, make granule, 50-60 DEG C of cold drying, control granule moisture content and be no more than 2%; Add carboxymethyl starch sodium (general consumption is the 0.5-5% of particle weight) again, appropriate magnesium stearate (general consumption is the 0.1-1% of particle weight), mixing; Calculate correct sheet heavy (general 0.1-0.4g), the upper and lower stamping press of adjustment tablet machine, control strip hardness and tablet weight variation scope, tabletted, film coating, qualified through quality inspection, obtain Sugarless type compound recipe three eggplant sheet.
Described excipient is one or more in starch, polyvidone, octadecanol, hexadecanol, stearic acid, citric acid, microcrystalline Cellulose, dextrin, lactose, mannitol, sodium bicarbonate, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, carboxymethyl starch sodium, low substituted hydroxy-propyl methylcellulose (L-HPC), crospolyvinylpyrrolidone, magnesium stearate, Pulvis Talci or micropowder silica gel etc.
Embodiment 2:
Respectively by Fructus Solani melongenae, Fructus Lycopersici esculenti, pyracantha fortuneana, Fructus Jujubae, Fructus Lycii, Radix Codonopsis and Semen Persicae through cleaning, after drying, be crushed to 100 orders, for subsequent use;
Get 15 weight portion Fructus Solani melongenae powder, 15 weight portion tomato meals, 15 weight portion pyracantha fortuneana powder, 15 weight portion red date powders, 0.8 weight portion medlar powder and 0.8 weight portion Radix Codonopsis powder fully to mix, obtain mixed powder;
The volume fraction adding 15 times of its weight in described mixed powder is ethanol reflux, extract, 2 times at 75 DEG C of 50%, and each 1h, filters, obtain the first filtrate and the first filtering residue;
The water adding 15 times of described mixed powder weight in described first filtering residue reflux, extract, 2 times at 75 DEG C, each 1h, filters, obtains the second filtrate and the second filtering residue;
Described first filtrate and described second filtrate are merged, and carries out concentrated and spraying dry, obtain extract powder;
By described extract powder, 0.8 weight portion peach kernel powder, appropriate excipient and flavoring agent, after mix homogeneously, dry granulation, tabletting, qualified through quality inspection, obtain compound recipe three eggplant buccal tablet.
Described flavoring agent is one or more in vitamin C, xylitol, stevioside, Oleum menthae, protein sugar, glycerol, sorbitol, mannitol, synthetic sweetener saccharin sodium or spice etc.Described excipient is one or more in starch, polyvidone, octadecanol, hexadecanol, stearic acid, citric acid, microcrystalline Cellulose, dextrin, lactose, mannitol, sodium bicarbonate, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, carboxymethyl starch sodium, low substituted hydroxy-propyl methylcellulose (L-HPC), crospolyvinylpyrrolidone, magnesium stearate, Pulvis Talci or micropowder silica gel etc.
Embodiment 3:
Respectively by Fructus Solani melongenae, Fructus Lycopersici esculenti, pyracantha fortuneana, Fructus Jujubae, Fructus Lycii, Radix Codonopsis and Semen Persicae through cleaning, after drying, be crushed to 100 orders, for subsequent use;
Get 20 weight portion Fructus Solani melongenae powder, 20 weight portion tomato meals, 20 weight portion pyracantha fortuneana powder, 20 weight portion red date powders, 1 weight portion medlar powder and 1 weight portion Radix Codonopsis powder fully to mix, obtain mixed powder;
The volume fraction adding 20 times of its weight in described mixed powder is 95% ethanol, reflux, extract, 2 times at 80 DEG C, each 1h, filters, obtains the first filtrate and the first filtering residue;
In described first filtering residue, add the water of 20 times of described mixed powder weight, reflux, extract, 2 times at 80 DEG C, each 1h, filter, filter, obtain the second filtrate and the second filtering residue;
Described first filtrate and described second filtrate are merged, and carries out concentrated and spraying dry, obtain extract powder;
By described extract powder, after 1 weight portion peach kernel powder mixing, in the ratio with cyclodextrin 1:1, add in cyclodextrin water saturation solution, and be fully ground to into pastel, cold drying, obtain cyclodextrin clathrate.Be framework material with hydroxypropyl emthylcellulose and acrylic resin, add polyvinylpyrrolidone and make binding agent, after mixing with described cyclodextrin clathrate, make soft material.By soft material cold drying, pulverize to obtain fine powder, getting fine powder again and add starch as diluent, is 95% ethanol for wetting agent is granulated with volume fraction, cold drying, granulate, finally add magnesium stearate as lubricant, tab weighs and pressure, tabletting, qualified through quality inspection, obtain compound recipe three eggplant slow release long-acting sheet.Its extended durations of action is to 3 ~ 5 times of conventional tablet.
Above-mentioned framework material is one or more in hydroxypropyl emthylcellulose, propenoic acid resin series, carboxymethyl cellulose and ethyl cellulose etc.The component of slow releasing preparation and weight percent content are:
Dried cream powder 10 ~ 50%,
Framework material 10 ~ 60%,
Diluent 15 ~ 70%,
Lubricant 0.1 ~ 1%,
The weight percent content summation of each component is 100%.
Embodiment 4:
In above-described embodiment 1-3, extract obtained powder is also by such as under type acquisition.
Respectively by Fructus Solani melongenae, Fructus Lycopersici esculenti, pyracantha fortuneana, Fructus Jujubae, Fructus Lycii, Radix Codonopsis and Semen Persicae through cleaning, after drying, be crushed to 80 orders, for subsequent use;
Get 12 weight portion Fructus Solani melongenae powder, 12 weight portion tomato meals, 12 weight portion pyracantha fortuneana powder, 12 weight portion red date powders, 0.6 weight portion medlar powder and 0.6 weight portion Radix Codonopsis powder fully to mix, obtain mixed powder;
The volume fraction adding 12 times of its weight in described mixed powder is 95% ethanol, and ultrasonic assistant extracts 1 time, each 0.5h, filters, obtains the first filtrate and the first filtering residue;
In described first filtering residue, add the water of 12 times of described mixed powder weight, reflux, extract, 2 times at 70 DEG C, each 1h, filter, obtain the second filtrate and the second filtering residue;
Described first filtrate and described second filtrate are merged, and carries out concentrated and spraying dry, obtain extract powder.
Embodiment 5:
In above-described embodiment 1-3, extract obtained powder is also by such as under type acquisition.
Respectively by Fructus Solani melongenae, Fructus Lycopersici esculenti, pyracantha fortuneana, Fructus Jujubae, Fructus Lycii, Radix Codonopsis and Semen Persicae through cleaning, after drying, be crushed to 100 orders, for subsequent use;
Get 18 weight portion Fructus Solani melongenae powder, 18 weight portion tomato meals, 18 weight portion pyracantha fortuneana powder, 18 weight portion red date powders, 0.8 weight portion medlar powder and 0.8 weight portion Radix Codonopsis powder fully to mix, obtain mixed powder;
The volume fraction adding 18 times of its weight in described mixed powder is 75% ethanol, and ultrasonic assistant extracts 2 times, each 0.5h, filters, obtains the first filtrate and the first filtering residue;
In described first filtering residue, add the water of 18 times of described mixed powder weight, reflux, extract, 2 times at 75 DEG C, each 1h, filter, obtain the second filtrate and the second filtering residue;
Described first filtrate and described second filtrate are merged, and carries out concentrated and spraying dry, obtain extract powder.
Embodiment 6:
In above-described embodiment 1-3, extract obtained powder is also by such as under type acquisition.
Respectively by Fructus Solani melongenae, Fructus Lycopersici esculenti, pyracantha fortuneana, Fructus Jujubae, Fructus Lycii, Radix Codonopsis and Semen Persicae through cleaning, after drying, be crushed to 100 orders, for subsequent use;
Get 10 weight portion Fructus Solani melongenae powder, 10 weight portion tomato meals, 10 weight portion pyracantha fortuneana powder, 10 weight portion red date powders, 1 weight portion medlar powder and 1 weight portion Radix Codonopsis powder fully to mix, obtain mixed powder;
The volume fraction adding 20 times of its weight in described mixed powder is 50% ethanol, and ultrasonic assistant extracts 3 times, each 0.5h, filters, obtains the first filtrate and the first filtering residue;
In described first filtering residue, add the water of 10 times of described mixed powder weight, reflux, extract, 2 times at 80 DEG C, each 1h, filter, obtain the second filtrate and the second filtering residue;
Described first filtrate and described second filtrate are merged, and carries out concentrated and spraying dry, obtain extract powder.
Embodiment 7:
In above-described embodiment 1-3, extract obtained powder is also by such as under type acquisition.
Respectively by Fructus Solani melongenae, Fructus Lycopersici esculenti, pyracantha fortuneana, Fructus Jujubae, Fructus Lycii, Radix Codonopsis and Semen Persicae through cleaning, after drying, pulverize for subsequent use;
By the proportioning of above-described embodiment, get Fructus Solani melongenae powder, tomato meal, pyracantha fortuneana powder, red date powder, medlar powder and Radix Codonopsis powder fully to mix, add mixed powder weight 10-20 ethanol doubly, supersound extraction or heating extraction 1 ~ 3 time, filter, and filtrate is through salting out method or acid-base method or ultrafiltration technology or adsorbing material process, use water and graded ethanol solutions eluting successively again, collect required treatment fluid or eluent, dry, obtain extract powder.
Described adsorbing material is a kind or 2 kinds in macroporous resin series, polyamide, polydextran gel and agarose gel etc.
Embodiment 8:
The clinical observation on the therapeutic effect of compound recipe three eggplant sheet treatment women chloasma.
1. clinical data
1.1 diagnostic criteria
" clinical diagnosis of chloasma and criterion of therapeutical effect " (2003) with reference to Dermatology Professional Committee of CAIM (Chinese Association Of Integrative Medicine) pigment disease group is formulated: 1. facial filbert to dark brown, well-defined patch, usual symmetry distribution, NIP performance and squama; 2. without obvious subjective symptoms; 3. women is multiple, after mainly occurring in adolescence; 4. the state of an illness can have certain seasonality, and the Chang Xiachong winter is light; 5. the pigmentation that other diseases (as naevus fuscocaerules zygomaticus, pigmentosa actinic lichen planus etc.) causes is got rid of.And get rid of: 1. skin lesion and the clear and definite relative of menstrual cycle; 2. gestation and women breast-feeding their children, under-18s or more than 50 years old person; 3. menorrhagia or menoxenia women; 4. cardiovascular and cerebrovascular vessel, liver, kidney, gastrointestinal and hemopoietic system serious disease person, psychotic; 5. contraceptive person's not enough half a year is withdrawn; 6. noncooperationist, comprises and can not adhere to treatment or privately add with other treatment, thus affect collection of data and efficacy evaluation person; Took the oral medicine relevant to primary disease in 30d before treatment, 7d is interior crosses the medicine for external use relevant to primary disease; Allergic constitution or to this medicine or ingredient allergy sufferers; Transsexual person patient etc.
1.2 physical data
Case is in December, 2013 ~ 2015 out-patients in year April, is married femle.Totally 45 examples, are divided into 2 groups at random.Treatment group 23 example, 28 ~ 45 years old age, average 34 years old; Average 5 years of the course of disease; Pregnant time average 3 times.Matched group 22 example, 27 ~ 45 years old age, average 34 years old; Average 5 years of the course of disease; Pregnant time average 3 times.2 groups of ages, the course of disease, pregnant inferior comparison, difference there are no significant meaning (P>0.05), has comparability.
2. Therapeutic Method
2.1 treatment group
Compound recipe three eggplant sheet, oral, 3 times on the one, each 2.
2.2 matched group
Vitamin C, each 0.2g, every day 3 times, oral; Vitamin E, each 0.1g, every day 3 times, oral.
Two groups was all 1 course for the treatment of with 30d, totally 3 courses for the treatment of.Curative effect is evaluated after the course for the treatment of.2 groups are all suspended treatment in menstrual phase.Withdraw similar drugs, stop aesthetic nursing and whitening cosmetics, anti-Exposure to Sunlight, avoid strong tea, coffee, oil are pungent, suitable vegetable and fruit, diet is light, drinks more water, and is in a light hearted mood, emotion is steady, free movement of the bowels, and sufficient sleep, stops using and affect medicine or the Therapeutic Method of this research.Statistical method adopts x
2inspection.
3. criterion of therapeutical effect, methods of marking and biochemical test Indexs measure
3.1 criterion of therapeutical effect
Basic healing: naked eyes to disappear >90% depending on mottle area, and color disappears substantially; Point system calculates rear index decreased >=0.8 for the treatment of.Effective: naked eyes to disappear >60% depending on mottle area, and color is obviously thin out; Point system calculates rear index decreased >=0.5 for the treatment of.Take a turn for the better: naked eyes to disappear >30% depending on mottle area, and color is thin out; Point system calculates rear index decreased >=0.3 for the treatment of.
Invalid: naked eyes to disappear <30% depending on mottle area, color change is not obvious; Point system calculates the rear index decreased <0 for the treatment of.
3.2 methods of marking
1. skin lesion area scoring: 0 is without skin lesion; 1 is skin lesion area <2cm2; 2 is skin lesion area 2 ~ 4cm2; 3 is skin lesion area >4cm2; 2. skin lesion color score: 0 is normal skin tone; 1 is filbert; 2 is brown; 3 is dark brown.Total mark=area scoring+color score.Index calculation method: total mark before index=(before treatment the rear total mark of total mark-treatment)/treatment.
3.3 biochemical test Indexs measure
Laboratory biochemical indicator detects Serum Sex Hormones estradiol (E2), testosterone (T), progesterone (P), superoxide dismutase (SOD), lipid peroxide catabolite malonaldehyde (MDA) and Hemorheological Data before and after treatment.
4. therapeutic outcome
4.1 liang of group Clinical efficacy comparisons, in table 1.
Table 1: two groups of Clinical efficacy comparisons (example (%))
Note: compare with matched group, * P<0.05.
Upper table shows that compound recipe three eggplant sheet curative effect is obviously better than vitamin, and over the course for the treatment of, treatment group and matched group all do not find untoward reaction after taking medicine.
The comparison of gonadal hormone before and after 4.2 liang of group treatments, in table 2.
Table 2: before and after two groups of treatments, gonadal hormone compares
Before and after the treatment of result display treatment group, E2, T have significant difference (P<0.05), and P difference is not remarkable; E2, T, P there are no significant difference before and after treatment of control group; After treatment, treatment group E2, T are compared with matched group, all have significant difference (P<0.05).
The comparison of SOD, MDA before and after 4.3 liang of group treatments, in table 3.
Table 3: the comparison of SOD, MDA before and after two groups of treatments
Result shows that treatment group treatment front and back SOD, MDA all have significant difference (P<0.05), and before and after treatment of control group, MDA has significant difference (P<0.05), and SOD difference is not remarkable; Compare for two groups after treatment, SOD has significant difference (P<0.05), MDA there was no significant difference.
Hemorheological comparison before and after 4.4 liang of group treatments, in table 4.
Table 4: hemorheological comparable group before and after two groups of treatments
Result display treatment group treatment Whole blood viscosity has significant difference (P<0.05), and packed cell volume difference is not remarkable; Treatment of control group Whole blood viscosity has significant difference (P<0.05), and packed cell volume difference is not remarkable; Compare except packed cell volume that all there were significant differences (P<0.05) for two groups after treatment.
5. discuss
Chloasma is commonly called as butterfly spot, cyasma, Chinese medicine thinks that it belongs to Chinese medicine and smokes black speck category, it is a kind of clinical common chronic skin metabolism of pigment obstacle disease, show as the yellowish-brown plaque-like pigmentation that two cheekbones and forehead position are butterfly distribution more, though no conscious sympton, have a strong impact on women's appearance and mental health.Primary disease is mainly because of liver,spleen,kidney functional disorder, and stagnation of liver-QI, insufficiency of the spleen, deficiency of the kidney thus cause functional activity of QI being not smooth, QI and blood is tired stagnant in venation, and face is lost caused by the self-restraint.Also think that its sick position is in skin (outward), the cause of disease is at internal organs (interior), and pathogenesis is mainly simulataneous insufficiency and excessive, and the empty stasis of blood is invaded mutually, and treatment runs through the tired rule for the treatment of of the kidney invigoratingization all the time.Control suitable the kidney invigorating, blood circulation and removing stasis.
Modern medicine study finds, in body, oxygen-derived free radicals and MDA pile up in vivo, and SOD content declines, the exception of hematodinamics index, and blood viscosity increases and the stagnant grade of the hyperamization liquid stasis of blood occurs relevant with chloasma, conforms to stagnation of QI-blood that Chinese medicine is said, venation block.Also find that the patient with chloasma E2 of renal deficiency type obviously reduces.
Compound recipe three eggplant sheet can play the effect of multicomponent multipath synergistic mechanism in vivo, not only realize traditional Chinese medicine therapy object, invigorating liver and spleen kidney blood, regulate mechanism of qi, blood circulation and removing stasis, and realize Modern medical therapy object, start with from internal body, restraint of tyrosinase is active, scavenging free radicals, improve SOD, improve patient's oxidative and anti-oxidative unbalance, regulate sex hormone's level, reduce blood viscosity, blood vessel dilating, improve blood flow state etc., thus improve environment, effective minimizing pigment or toxin calmness, moist face skin, improve the colour of skin, reach certain freckle removing and whitening and antidotal effect.Can with the use of local topical skin makeup cream, Chinese medicine nourishing and toxin expelling of returning other gentlenesses such as stilbene blood nourishing oral liquid for oral administration, avoids excessive Exposure to Sunlight, sufficient sleep and light diet etc., stiffening effect.
Embodiment 9:
Model case
Huang, female, 35 years old, first visit date: on February 19th, 2015.Face chloasma 2 years, deepens gradually, is many with the bridge of the nose and facial area, and in brown spot, clear-cut margin, color burn during menstrual onset, throughout volume, cheek, nose, in mouth week etc., symmetry occurs.Speckle color is brown black, and complexion is dark dim, disorder of menstrual cycle, irritability, and with fatigue and weak, indigestion and loss of appetite sleepy, body of the tongue is light red, while there is indentation, and few tongue, thready pulse.Diagnosis: chloasma faciei, card belongs to deficiency of the liver and kindey and accompanies insufficiency of the spleen chloasma, and the deficiency of YIN causes yang hyperactivity, interior raw asthenic fire.Take this product about 3 months, reach tonification Yuanyang, nourish essence and blood, the effect of eliminating blood stasis and removing ecchymoses, part spot disappears substantially.Biochemical laboratory detects blood serum E2, T, SOD, MDA and Hemorheological Data before and after treatment simultaneously, and change all has significant difference.Follow up a case by regular visits to 3 months afterwards, have no recurrence.
Lee, female, 18 years old, first visit date: on March 3rd, 2015.Heritability freckle is many with the bridge of the nose and facial area, in yellowish-brown, within nearly 2 years, has freckle color burn, and freckle such as to increase at the symptom.Take this product 3 months, freckle color is thin out, and naked eyes to disappear >30% depending on freckle area, and the colour of skin is ruddy.
Liu, female, 23 years old, first visit date: 2015 month July 25.Went to the beach with classmate before 1 month graduation travelling, and occur face and arm red swelling of the skin after going home, burn, more, speckle appears in the bridge of the nose and face.Diagnosis: sunburn.Take this product 3 months, sunburn color is obviously thin out, and naked eyes to disappear >60% depending on sunburn area, and the colour of skin is ruddy pale.
Wang, female, 55 years old, first visit date: on May 28th, 2015.Early stage sign phenomenon is: facial HUANGBAI(sic), and sclerosis of blood vessels causes mini strokes, and hypomnesis, irritable, fatigue and weakness, prolonged constipation, belongs to typical senile symptom.Take this product after 4 months, facial HUANGBAI(sic) and constipation symptom disappear, and emotion is steady, muscle power and spirit are clearly better, senile symptom obtains effective the suppression and alleviation, and biochemical laboratory detects SOD in serum, MDA and Hemorheological Data before and after treatment simultaneously, changes and all has significant difference.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details.
Claims (9)
1. the compound recipe three eggplant sheet of a speckle removing, antisenescence, it is characterized in that, obtain primarily of following raw material by weight: Fructus Solani melongenae powder 10-20 part, tomato meal 10-20 part, pyracantha fortuneana powder 10-20 part, red date powder 10-20 part, medlar powder 0.5-1 part, Radix Codonopsis powder 0.5-1 part and peach kernel powder 0.5-1 part.
2. the compound recipe three eggplant sheet of speckle removing, antisenescence as claimed in claim 1, it is characterized in that, described Fructus Solani melongenae powder, tomato meal, pyracantha fortuneana powder, red date powder, medlar powder, Radix Codonopsis powder and peach kernel powder, its be respectively by Fructus Solani melongenae, Fructus Lycopersici esculenti, pyracantha fortuneana, Fructus Jujubae, Fructus Lycii, Radix Codonopsis and Semen Persicae through cleaning, after drying, be crushed to 80-100 order, obtained.
3. a preparation method for the compound recipe three eggplant sheet of speckle removing, antisenescence as claimed in claim 1, is characterized in that, comprise the steps:
Step one: the described Fructus Solani melongenae powder of above-mentioned weight portion, tomato meal, pyracantha fortuneana powder, red date powder, medlar powder and Radix Codonopsis powder are fully mixed, obtains mixed powder;
Step 2, the ethanol of 10-20 times adding its weight in described mixed powder carry out alcohol extraction, filter, obtain the first filtrate and the first filtering residue;
Step 3, the water adding 10-20 doubly described mixed powder weight in described first filtering residue carry out water extraction, filter, obtain the second filtrate and the second filtering residue;
Step 4, described first filtrate and described second filtrate to be merged, and carry out concentrated and spraying dry, obtain extract powder;
Step 5: by the peach kernel powder of described extract powder, above-mentioned weight portion and adjuvant mixing, through pelletize, tabletting, obtain described compound recipe three eggplant sheet.
4. the preparation method of the compound recipe three eggplant sheet of speckle removing, antisenescence as claimed in claim 3, it is characterized in that, in described step 2, described alcohol extraction refers to that by volume fraction be the ethanol of 50%-95%, reflux, extract, 2 times at 70-80 DEG C, each 1h.
5. the preparation method of the compound recipe three eggplant sheet of speckle removing, antisenescence as claimed in claim 3, it is characterized in that, in described step 2, described alcohol extraction refers to that by volume fraction be the ethanol of 50%-95%, and ultrasonic assistant extracts 1-3 time, each 0.5h.
6. the preparation method of the compound recipe three eggplant sheet of speckle removing, antisenescence as claimed in claim 3, is characterized in that, in described step 3, described water extraction refers to described first filtering residue and water reflux, extract, 2 times at 70-80 DEG C, each 1h.
7. the preparation method of the compound recipe three eggplant sheet of speckle removing, antisenescence as claimed in claim 3, it is characterized in that, described compound recipe three eggplant sheet, it comprises Sugarless type compound recipe three eggplant sheet, compound recipe three eggplant buccal tablet and compound recipe three eggplant slow release long-acting sheet.
8. one kind as arbitrary in claim 1-7 as described in the application of compound recipe three eggplant sheet of speckle removing, antisenescence, it is characterized in that, the skin skin dark stain that described compound recipe three eggplant sheet causes for preventing and treating the chromatopathys such as freckle, chloasma, sunburn, skin whitening or improve the colour of skin, defying age.
9. the application of the compound recipe three eggplant sheet of speckle removing, antisenescence as claimed in claim 8, it is characterized in that, described compound recipe three eggplant sheet is used for preventing and treating freckle, chloasma and sunburn.
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| CN201510780779.8A CN105267435A (en) | 2015-11-13 | 2015-11-13 | Freckle-removing anti-aging compound Sanqie tablet and its preparation method and application |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1463743A (en) * | 2002-06-29 | 2003-12-31 | 王勇智 | Capsule possessing antisenescent and spot dispelling effect and method for making the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1463743A (en) * | 2002-06-29 | 2003-12-31 | 王勇智 | Capsule possessing antisenescent and spot dispelling effect and method for making the same |
Non-Patent Citations (4)
| Title |
|---|
| 刘利萍等: "《实用美容药物常识》", 30 September 2013 * |
| 周玲仙等: "《云南特有食物图鉴》", 31 March 2012 * |
| 周范林: "《女性朋友容保美健的最佳食物》", 30 June 2012 * |
| 孙晓生: "《孙晓生中医养生文丛（第一辑）》", 30 September 2014 * |
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