CN105264086B - 用于流感诊断的方法和试剂盒 - Google Patents

用于流感诊断的方法和试剂盒 Download PDF

Info

Publication number
CN105264086B
CN105264086B CN201480031254.8A CN201480031254A CN105264086B CN 105264086 B CN105264086 B CN 105264086B CN 201480031254 A CN201480031254 A CN 201480031254A CN 105264086 B CN105264086 B CN 105264086B
Authority
CN
China
Prior art keywords
neuraminidase
influenza
assay
test
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201480031254.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN105264086A (zh
Inventor
R·坎贝尔
K·G·多兰
E·法洛斯
R·A·霍克
R·雅各布森
J·B·皮特纳
G·冯克
R·卡赫尔
U·古拉蒂
H·伊梅尔
R·B·埃文斯斯托姆斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Priority to CN201810491986.5A priority Critical patent/CN108663518B/zh
Publication of CN105264086A publication Critical patent/CN105264086A/zh
Application granted granted Critical
Publication of CN105264086B publication Critical patent/CN105264086B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201480031254.8A 2013-04-01 2014-04-01 用于流感诊断的方法和试剂盒 Active CN105264086B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810491986.5A CN108663518B (zh) 2013-04-01 2014-04-01 用于流感诊断的方法和试剂盒

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361807185P 2013-04-01 2013-04-01
US61/807,185 2013-04-01
PCT/US2014/032567 WO2014165536A1 (en) 2013-04-01 2014-04-01 Methods and kits for the diagnosis of influenza

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810491986.5A Division CN108663518B (zh) 2013-04-01 2014-04-01 用于流感诊断的方法和试剂盒

Publications (2)

Publication Number Publication Date
CN105264086A CN105264086A (zh) 2016-01-20
CN105264086B true CN105264086B (zh) 2018-06-15

Family

ID=50625220

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201480031254.8A Active CN105264086B (zh) 2013-04-01 2014-04-01 用于流感诊断的方法和试剂盒
CN201810491986.5A Active CN108663518B (zh) 2013-04-01 2014-04-01 用于流感诊断的方法和试剂盒

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201810491986.5A Active CN108663518B (zh) 2013-04-01 2014-04-01 用于流感诊断的方法和试剂盒

Country Status (11)

Country Link
US (3) US10317404B2 (enExample)
EP (1) EP2981618B1 (enExample)
JP (2) JP6591398B2 (enExample)
KR (1) KR102348484B1 (enExample)
CN (2) CN105264086B (enExample)
AU (2) AU2014248225B2 (enExample)
BR (1) BR112015025042B1 (enExample)
CA (1) CA2908028C (enExample)
ES (1) ES2754402T3 (enExample)
RU (1) RU2713112C2 (enExample)
WO (1) WO2014165536A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6411740B2 (ja) * 2013-01-15 2018-10-24 国立大学法人広島大学 ノイラミニダーゼ活性阻害剤の有効性を判定するための組成物、キットおよびその利用
JP6591398B2 (ja) 2013-04-01 2019-10-16 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ インフルエンザ診断のための方法及びキット
US10520498B2 (en) 2017-03-14 2019-12-31 Becton, Dickinson And Company Devices and techniques for oral fluid collection and seroprotection testing
CN110832083A (zh) * 2017-07-04 2020-02-21 卡维迪有限公司 用于通过测量酶活性来评估病毒对治疗的敏感性的方法及其系统
WO2019060275A1 (en) 2017-09-21 2019-03-28 Becton, Dickinson And Company DEMARCATION TEMPLATE FOR DANGEROUS CONTAMINANT TEST
AU2018337030B2 (en) 2017-09-21 2025-04-10 Becton, Dickinson And Company Hazardous contaminant collection kit and rapid testing
US11360001B2 (en) 2017-09-21 2022-06-14 Becton, Dickinson And Company Reactive demarcation template for hazardous contaminant testing
CN209400540U (zh) 2017-09-21 2019-09-17 贝克顿·迪金森公司 危险污染检测系统和收集装置
WO2019060276A1 (en) 2017-09-21 2019-03-28 Becton, Dickinson And Company INCREASED REALITY DEVICES FOR DANGEROUS CONTAMINANT TESTING
CN209400423U (zh) * 2017-09-21 2019-09-17 贝克顿·迪金森公司 横向流测定物、测定物读取器装置和包括其的系统
AU2018337028B2 (en) * 2017-09-21 2025-05-08 Becton, Dickinson And Company Sampling systems and techniques to collect hazardous contaminants with high pickup and shedding efficiencies
CN111741951B (zh) * 2018-03-02 2023-08-18 日本农药株式会社 酰胺化合物或其盐类、以及含有这些化合物的农业园艺用杀菌剂及其使用方法
KR102129937B1 (ko) * 2018-07-31 2020-07-03 재단법인 아산사회복지재단 종이기반 핵산검출용 키트 및 pcr 증폭산물을 분석하기 위한 방법
EP3774841A1 (en) 2018-08-27 2021-02-17 Regeneron Pharmaceuticals, Inc. Use of raman spectroscopy in downstream purification
CN212748381U (zh) 2019-01-28 2021-03-19 贝克顿·迪金森公司 一种有害污染物检测系统和一种有害污染物收集装置
JPWO2020196295A1 (enExample) * 2019-03-25 2020-10-01
KR20230048505A (ko) * 2020-06-15 2023-04-11 뉴옴 펩타이즈 피티이. 엘티디. 분석물의 검출을 위한 측면 유동 검정 장치 및 이의 검출 방법
JP2022018768A (ja) * 2020-07-16 2022-01-27 デンカ株式会社 簡易鼻腔粘膜表面付着粘液の採取方法および該検体中の被検出物を検出するための検査キット
KR20220060269A (ko) 2020-11-04 2022-05-11 인텔로스 주식회사 코로나 바이러스 감염증 및 인플루엔자 바이러스 감염증 동시 진단키트
KR102265441B1 (ko) * 2020-12-23 2021-06-15 충남대학교 산학협력단 화학 발광 기반의 조류 인플루엔자 바이러스 검출용 조성물 및 이의 용도
CN115015541A (zh) 2021-03-05 2022-09-06 全球诊断系统受益有限责任公司 带流体贮存器的诊断装置及相关方法和试剂盒
JP2023016529A (ja) * 2021-07-21 2023-02-02 東洋紡株式会社 イムノクロマト試験片
JP2023016530A (ja) * 2021-07-21 2023-02-02 東洋紡株式会社 イムノクロマト試験片
US20250066867A1 (en) * 2023-08-23 2025-02-27 Vedabio, Inc. Rapid detection of known and emerging influenza viruses

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1324954A (zh) * 1996-09-25 2001-12-05 俄克拉何马州医学研究基金会 在临床样本中检测流行性感冒a型和b型病毒的方法
CN101437550A (zh) * 2006-05-10 2009-05-20 赛拉诺斯股份有限公司 流感病毒的实时检测
CN101553732A (zh) * 2006-08-31 2009-10-07 大阪府 对禽流感病毒的特异性快速诊断法
WO2010139047A1 (en) * 2009-06-01 2010-12-09 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health Reagents and methods for detecting influenza virus proteins

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4590169A (en) 1983-11-18 1986-05-20 Beckman Instruments, Inc. Direct particle agglutination immunoassays avoiding false negatives at high antigen concentrations
US4810631A (en) 1986-05-12 1989-03-07 Becton, Dickinson And Company Signal enhancement in immunoassay by modulation of chemical catalysis
US4835099A (en) 1986-11-20 1989-05-30 Becton, Dickinson And Company Signal enhancement in immunoassay by modulation of enzymatic catalysis
US5017473A (en) 1987-05-26 1991-05-21 Becton, Dickinson And Company Homogeneous chemiluminescence immunoassay using a light absorbing material
US4904583A (en) 1987-05-26 1990-02-27 Becton, Dickinson And Company Cascade immunoassay by multiple binding reactions
CA2000678A1 (en) * 1988-11-17 1990-05-17 John E. Reardon Chromogenic substrate for esterase and immunoassay using same
CA2072368C (en) 1989-12-29 1998-06-30 Gregory A. Turner Methods for diagnosing human influenza and 4-position modified chromogenic n-acetylneuraminic acid substrates for use therein
US5314801A (en) 1992-11-06 1994-05-24 Becton, Dickinson And Company Probes to Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium paratuberculosis
US5470723A (en) 1993-05-05 1995-11-28 Becton, Dickinson And Company Detection of mycobacteria by multiplex nucleic acid amplification
US5457027A (en) 1993-05-05 1995-10-10 Becton, Dickinson And Company Internal controls for isothermal nucleic acid amplification reactions
US5518884A (en) 1994-02-28 1996-05-21 Becton, Dickinson And Company Nucleic acid sequences specific for mycbacterium kansasii
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US5998221A (en) 1996-09-25 1999-12-07 Becton, Dickinson And Company Non-instrumented assay with quantitative and qualitative results
US6194220B1 (en) 1996-09-25 2001-02-27 Becton, Dickinson And Company Non-instrumented assay with quantitative and qualitative results
TR199901081T2 (xx) 1996-11-14 1999-08-23 Biota Scientific Management Pty.Ltd. Y�ntem ve bu y�ntemde kullan�lan yeni bile�imler.
CA2314431A1 (en) * 1997-12-18 1999-06-24 Sepracor Inc. Screening assays for the detection and diagnosis of influenza virus
US6267722B1 (en) 1998-02-03 2001-07-31 Adeza Biomedical Corporation Point of care diagnostic systems
US6394952B1 (en) 1998-02-03 2002-05-28 Adeza Biomedical Corporation Point of care diagnostic systems
US6303764B1 (en) 1998-09-24 2001-10-16 Zymetx, Inc. Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids
WO2000063423A2 (en) 1999-04-16 2000-10-26 Zymetx, Inc. Viral detection method using viral encoded enzymes and chemiluminescent substrates
US6420552B1 (en) 1999-09-10 2002-07-16 Zymetx, Inc. Syntheses of 4-alkyl chromogenic glycosides and 7-alkyl chromogenic glycosides of N-acetylneuraminic acids
EP1253203A1 (en) 2001-04-25 2002-10-30 Becton Dickinson and Company Rapid resuscitation, growth, capture and detection of microorganisms
AU2004235349B2 (en) 2003-04-25 2009-11-19 Becton, Dickinson And Company Detection of herpes simplex virus types 1 and 2 by nucleic acid amplification
US7595152B2 (en) 2005-07-01 2009-09-29 Arbor Vita Corporation Detection of influenza virus
WO2007053487A2 (en) 2005-10-28 2007-05-10 Binax, Inc. Methods and devices for detection of the strain of a pathogen
US8163237B2 (en) 2006-05-08 2012-04-24 Becton, Dickinson And Company Vascular access device pathogenic status indication
WO2007135099A1 (en) 2006-05-18 2007-11-29 Veterinärmedizinische Universität Wien Detection method for influenza viruses
JP2008014751A (ja) 2006-07-05 2008-01-24 Denka Seiken Co Ltd 着色ラテックス粒子を用いるメンブレンアッセイ法およびキット
CA2684998A1 (en) * 2007-04-30 2009-01-29 Nanogen, Inc. Multianalyte assay
US7893272B2 (en) * 2007-05-15 2011-02-22 Cellex, Inc. Reagents and kits for detection of influenza virus and the like
US8163474B2 (en) * 2008-03-15 2012-04-24 Arbor Vita Corporation NS1-NP diagnostics of influenza virus infection
JP6591398B2 (ja) 2013-04-01 2019-10-16 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ インフルエンザ診断のための方法及びキット

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1324954A (zh) * 1996-09-25 2001-12-05 俄克拉何马州医学研究基金会 在临床样本中检测流行性感冒a型和b型病毒的方法
CN101437550A (zh) * 2006-05-10 2009-05-20 赛拉诺斯股份有限公司 流感病毒的实时检测
CN101553732A (zh) * 2006-08-31 2009-10-07 大阪府 对禽流感病毒的特异性快速诊断法
WO2010139047A1 (en) * 2009-06-01 2010-12-09 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health Reagents and methods for detecting influenza virus proteins

Also Published As

Publication number Publication date
JP2016524127A (ja) 2016-08-12
JP6591398B2 (ja) 2019-10-16
CA2908028C (en) 2022-10-18
RU2713112C2 (ru) 2020-02-03
US12372525B2 (en) 2025-07-29
AU2014248225B2 (en) 2020-06-25
JP7096219B2 (ja) 2022-07-05
CN108663518A (zh) 2018-10-16
US20190339272A1 (en) 2019-11-07
CA2908028A1 (en) 2014-10-09
US11209433B2 (en) 2021-12-28
WO2014165536A8 (en) 2016-09-01
KR102348484B1 (ko) 2022-01-07
ES2754402T3 (es) 2020-04-17
AU2020227005A1 (en) 2020-09-17
BR112015025042A2 (enExample) 2017-09-05
US20220146514A1 (en) 2022-05-12
RU2015141509A3 (enExample) 2018-03-30
BR112015025042B1 (pt) 2023-11-14
WO2014165536A1 (en) 2014-10-09
KR20160018479A (ko) 2016-02-17
EP2981618A1 (en) 2016-02-10
AU2014248225A1 (en) 2015-10-29
CN105264086A (zh) 2016-01-20
CN108663518B (zh) 2022-03-11
RU2015141509A (ru) 2017-05-16
US20160041167A1 (en) 2016-02-11
AU2020227005B2 (en) 2022-12-08
EP2981618B1 (en) 2019-08-28
JP2019215377A (ja) 2019-12-19
US10317404B2 (en) 2019-06-11

Similar Documents

Publication Publication Date Title
CN105264086B (zh) 用于流感诊断的方法和试剂盒
Najjar et al. A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma
Fabiani et al. Magnetic beads combined with carbon black-based screen-printed electrodes for COVID-19: A reliable and miniaturized electrochemical immunosensor for SARS-CoV-2 detection in saliva
JP2023520754A (ja) ＳＡＲＳ－ＣｏＶ－２ウイルスの迅速で現場配備可能な検出
Eom et al. Diagnosis of Tamiflu-resistant influenza virus in human nasal fluid and saliva using surface-enhanced Raman scattering
US20200166528A1 (en) Methods for Improving Assays of Biological Samples
Tabata et al. Antibody-free digital influenza virus counting based on neuraminidase activity
Kato et al. An easy, rapid, and sensitive method for detection of drug-resistant influenza virus by using a sialidase fluorescent imaging probe, BTP3-Neu5Ac
Zhang et al. Neuraminidase-activatable NIR fluorescent probe for influenza virus ratiometric imaging in living cells and colorimetric detection on cotton swabs
Chabi et al. Smartphone-read phage lateral flow assay for point-of-care detection of infection
Diao et al. Molecular detections of coronavirus: current and emerging methodologies
EP4085245B1 (en) Method and device for analysis of liquid samples
Yamaguchi Salivary sensors in point-of-care testing
Zhang et al. Diagnostic assays for COVID-19: A narrative review
Rashid et al. Nanobioengineering Approach for Early Detection of SARS‐CoV‐2
Das Design and development of small molecule based biosensors for detection of pathogens
Wanga et al. Micro/Nano biomedical devices for point-of-care diagnosis of infectious respiratory diseases
Sauer-Budge New Technologies for the Rapid Identification of Drug-Resistant Bacteria

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB03 Change of inventor or designer information

Inventor after: Campbell Robert

Inventor after: H Himel

Inventor after: R B Evans, storm

Inventor after: Dolan Kevin G.

Inventor after: E Farris

Inventor after: HOKE RANDAL ALAN

Inventor after: Jacobson Robert A.

Inventor after: Pitner J. Bruce

Inventor after: Vonk Glenn

Inventor after: R kachel

Inventor after: U - Ancient Lydia

Inventor before: Campbell Robert

Inventor before: H Himel

Inventor before: R B Evans, storm

Inventor before: Dolan Kevin G.

Inventor before: E Farris

Inventor before: HOKE RANDAL ALAN

Inventor before: Jacobson Robert A.

Inventor before: B - J - pitner

Inventor before: Vonk Glenn

Inventor before: R kachel

Inventor before: U - Ancient Lydia

COR Change of bibliographic data
GR01 Patent grant
GR01 Patent grant