CN105233059A - Medicine composition for treating hepatopathy and preparing method thereof - Google Patents
Medicine composition for treating hepatopathy and preparing method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composition for treating hepatopathy and a preparing method thereof. The medicine composition for treating hepatopathy is prepared from oriental grape roots, oat, pedicularis megalochila, iris dichotoma, schoepfia chinensis, common yellowflax leaves, sinopimelodendron kwangsiense, corydalis delavayi, aralia mandshurica, saussurea nigrescens, eryngium foetidum, bauhinia variegata, cynolgossum officinale, adinandra mellettii, marsdenia tinctoria, meehania urticifolia, eriophyton wallichii and colquhounia coccinea. According to the medicine composition, the traditional Chinese medicinal materials are reasonably matched, medicine ingredients generate the synergetic function accordingly, the medicine composition can have the treatment effect on various kinds of hepatopathy, and injured hepatic cells can be repaired; the traditional Chinese medicinal ingredients such as scutellaria baicalensis and coptis chinensis with the anti-inflammation effect are combined, the traditional Chinese medicinal materials can achieve the synergetic effect, the treatment effect on the hepatopathy diseases is improved, repairing of the hepatic cells is promoted, and immunity is improved; vitamins C, vitamins B and penicillin are added, nutrients and energy are provided for the hepatic cells, and then the aim of rapidly repairing the hepatic cells is achieved.
Description
Technical field
The present invention relates to hepatopathy practical technique field, specifically relate to a kind of pharmaceutical composition for the treatment of hepatopathy and preparation method thereof.
Background technology
Hepatitis, liver cirrhosis, hepatic ascites are common hepatopathys, and the healthy of the people in its serious harm.The cause of disease of causing a disease due to it is complicated, as treatment in time or therapeutic effect not good, the state of an illness will worsen.At present, medically to the treatment of above-mentioned hepatopathy, especially the treatment of hepatitis B etc., main employing be antiviral therapy, the indication having it clear and definite due to antiviral therapy and contraindication, and being subject to the impact of the reasons such as economic condition, the patient that can receive regular antiviral therapy is at present also more limited, so Most patients can only be protected the liver by antiinflammatory stop further developing of disease.
Based on this, also have researcher to engage in and adopt the research of Chinese medicine composition to liver disease, if the patent No. is 201310044232.2, " a kind of Chinese medicine for the treatment of hepatitis, liver cirrhosis, hepatic ascites " is broken away from antiviral Therapeutic Method for liver disease and is brought a kind of new approaches; However, the demand for liver disease medication field is also relatively large, and is only confined to this several Chinese crude drug and treats, and make the cost of hepatopathy treatment by Chinese herbs higher, even treatment cycle is longer, and effect is also not remarkable.
Based on this, this researcher combines for many years to trial and the exploration of liver disease, Chinese medicine, Western medicine is used for the treatment of hepatopathy after combining and being prepared into oral liquid, for liver disease brings a kind of new approaches.
Summary of the invention
The technical problem that the present invention solves is to provide a kind of pharmaceutical composition for the treatment of hepatopathy and preparation method thereof.
Technical scheme of the present invention is:
Treat a pharmaceutical composition for hepatopathy, its material composition is by weight: Pueraria lobota Bud root 5 ~ 7 parts, Semen Avenae fatuae 4 ~ 8 parts, large lip Radix seu Herba Pedicularis 3 ~ 7 parts, flat cattail leaf fan 1 ~ 3 part, magnificent Ramulus et Folium Schoepfiae chinesis 3 ~ 10 parts, Ramulus et Folium Reinwardtiae Trigynae 2 ~ 7 parts, sinopimelodendron kwangsiense 3 ~ 6 parts, Cangshan Herba corydalis racemosae 5 ~ 9 parts, Cortex Araliae Elatae Radicis 1 ~ 3 part, Herba saussureae nigrescentis 1 ~ 5, thorn coriander 3 ~ 6 parts, Flos Bauhiniae Variegatae 2 ~ 8 parts, Herba Carpesii Cernui 1 ~ 9 part, Adinandra millettii 2 ~ 10 parts, Caulis Marsdeniae tinctoriae 5 ~ 10 parts, Meehania urticaefolia 4 ~ 9 parts, Eriophyton wallichii Benth 2 ~ 5 parts, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain 3 ~ 7 parts.
Further, described material composition is by weight: Pueraria lobota Bud root 6 parts, Semen Avenae fatuae 6 parts, large lip Radix seu Herba Pedicularis 5 parts, flat cattail leaf fan 2 parts, magnificent Ramulus et Folium Schoepfiae chinesis 6.5 parts, Ramulus et Folium Reinwardtiae Trigynae 4.5 parts, sinopimelodendron kwangsiense 4.5 parts, Cangshan Herba corydalis racemosae 7 parts, Cortex Araliae Elatae Radicis 2 parts, Herba saussureae nigrescentis 3 parts, thorn coriander 4.5 parts, Flos Bauhiniae Variegatae 5 parts, Herba Carpesii Cernui 5 parts, Adinandra millettii 6 parts, Caulis Marsdeniae tinctoriae 7.5 parts, Meehania urticaefolia 6.5 parts, Eriophyton wallichii Benth 3.5 parts, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain 5 parts.
Further, described material composition also comprises by weight: Radix Scutellariae 0.2 ~ 0.7 part, Rhizoma Coptidis 0.1 ~ 0.3 part, Cortex Phellodendri 0.3 ~ 0.7 part, Radix Gentianae 0.1 ~ 0.3 part, Cortex Fraxini 0.1 ~ 0.3 part, Radix Sophorae Flavescentis 0.3 ~ 0.7 part, Herba Taraxaci 0.1 ~ 0.3 part, Herba Menthae 0.1 ~ 0.3 part, Flos Chrysanthemi Indici 0.1 ~ 0.3 part.
Further, described material composition also comprises by weight: Radix Scutellariae 0.45 part, Rhizoma Coptidis 0.2 part, Cortex Phellodendri 0.5 part, Radix Gentianae 0.2 part, Cortex Fraxini 0.2 part, Radix Sophorae Flavescentis 0.5 part, Herba Taraxaci 0.2 part, Herba Menthae 0.2 part, Flos Chrysanthemi Indici 0.2 part.
Further, described material composition also comprises vitamin B 0.01 ~ 0.03 part, vitamin C 0.01 ~ 0.04 part, penicillin 0.0001 ~ 0.0003 part by weight.
Treat a preparation method for the pharmaceutical composition of hepatopathy, comprise the following steps:
(1) the Pueraria lobota Bud root of formula ratio is got, Semen Avenae fatuae, large lip Radix seu Herba Pedicularis, flat cattail leaf fan, China's Ramulus et Folium Schoepfiae chinesis, sinopimelodendron kwangsiense, Cangshan Herba corydalis racemosae, Cortex Araliae Elatae Radicis, Herba saussureae nigrescentis, Flos Bauhiniae Variegatae, Adinandra millettii, Caulis Marsdeniae tinctoriae, Meehania urticaefolia, Eriophyton wallichii Benth, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain, add the water of 8 ~ 10 times of medical material gross weight, soak 40 ~ 50 minutes in 40 ~ 45 DEG C of constant temperature, be placed in boiler and decoct extraction 1 ~ 3 time, each 1 ~ 3 hour, filter, obtain and merging filtrate, filtrate is evaporated to the extractum that relative density is 1.25 ~ 1.35 at 70 DEG C, adding ethanol to alcohol content is 80 ~ 90%v/v, leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, obtain active components A, for subsequent use,
(2) thorn coriander, the Herba Carpesii Cernui of formula ratio is got, the volume by volume concentration adding medical material gross weight 1 ~ 2 times is the alcohol dipping 30 ~ 40 hours of 60% ~ 70%, then with volume by volume concentration be 50 ~ 60% ethanol carry out percolation with the speed accounting for raw material total weight parts 0.5 ~ 0.7% per minute, collect the percolate being equivalent to medical material gross weight 3 ~ 10 times amount, reclaim ethanol, be evaporated to 1 ~ 1.6 times that is equivalent to medical material gross weight, filter, obtain active component B, for subsequent use;
(3) getting the Ramulus et Folium Reinwardtiae Trigynae of formula ratio, is the water soaking 10 ~ 15min of 85 ~ 95 DEG C by the temperature relative to its weight 20 ~ 30 times, filters, under filtrate reduced in volume to 70 DEG C environment, relative density is the extractum of 1.25 ~ 1.35, spray dried becomes extract powder, obtains active component C, for subsequent use;
(4) get the Radix Scutellariae of formula ratio, Rhizoma Coptidis, Cortex Phellodendri, Radix Gentianae, Cortex Fraxini, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Menthae, Flos Chrysanthemi Indici, dry, pulverize, add the soak by water 1 ~ 1.5h of medical material gross weight 6 ~ 10 times amount, filter; Filtering residue adds the soak by water 0.5 ~ 1.0h of medical material gross weight 5 ~ 6 times amount, filters; Merge twice filtrate, being evaporated to relative density under 70 DEG C of environment is the extractum of 1.25 ~ 1.35, dry, pulverize rear mistake 80 ~ 100 mesh sieve, obtains active component D, for subsequent use;
(5) 200 ~ 280 parts of waters for injection are got, above-mentioned active components A, active component B, active component C, active component D are dissolved in wherein, add vitamin B, vitamin C, penicillin, add the emulsifying agent, the antiseptic of 0.05 ~ 0.08%, the antioxidant of 0.03 ~ 0.06% that are equivalent to described water for injection weight 0.08 ~ 0.1% again, and be placed in ultrasonic disperse equipment and carry out supersound process 10 ~ 20s with the frequency of 40 ~ 60Hz, namely obtain the drug composition oral liquid for the treatment of hepatopathy.
Further, in described step (3), spray drying condition is: inlet temperature is 100 ~ 120 DEG C, and leaving air temp is 80 ~ 90 DEG C, and temperature of charge is 70 ~ 90 DEG C, and atomizing pressure is 0.2 ~ 0.4 MPa, and spray velocity is 5 ~ 10ml/s.
Further, described emulsifying agent be selected from sodium lauryl sulphate, sucrose monolaurate or fatty acid Pyrusussuriensis smooth in any one.
Further, described antiseptic be selected from parabens, benzoate or sorbic acid any one.
Further, described antioxidant is selected from any one in BHT, sodium sulfite or sodium pyrosulfite.
The invention has the beneficial effects as follows: by Pueraria lobota Bud root, Semen Avenae fatuae, large lip Radix seu Herba Pedicularis, flat cattail leaf fan, magnificent Ramulus et Folium Schoepfiae chinesis, Ramulus et Folium Reinwardtiae Trigynae, sinopimelodendron kwangsiense, Cangshan Herba corydalis racemosae, Cortex Araliae Elatae Radicis, Herba saussureae nigrescentis, thorn coriander, Flos Bauhiniae Variegatae, Herba Carpesii Cernui, Adinandra millettii, Caulis Marsdeniae tinctoriae, Meehania urticaefolia, Eriophyton wallichii Benth, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain are carried out rational proportioning, each herbal medicine composition is made to produce mutually collaborative effect, and can be all effective in cure to various hepatopathy, repair the hepatocyte of damage; The Chinese medicine ingredients in conjunction with Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Gentianae, Cortex Fraxini, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Menthae, Flos Chrysanthemi Indici with anti-inflammatory effect adds wherein, and then make cooperative effect to occur between these Chinese medicines, strengthen hepatopathy curative effect, promote hepatocellular reparation, enhancing immunity; Vitamin C, vitamin B and penicillin are joined wherein, make the rich in nutrition content of the compositions for the treatment of hepatopathy, in the process that hepatopathy is treated, nutrition and energy can also be provided for hepatocyte, and then reach the hepatocellular object of reparation fast, simultaneously, by multiple, there is the Chinese medicine ingredients of anti-inflammatory analgetic effect and the combination of Western medicine, and then make to be enhanced to the degree of killing of hepatopathy pathogenic bacteria, and alleviate the misery of patient, reduce the cost of medication.
Detailed description of the invention
Embodiment 1:
Treat a pharmaceutical composition for hepatopathy, its material composition is by weight: Pueraria lobota Bud root 5 parts, Semen Avenae fatuae 4 parts, large lip Radix seu Herba Pedicularis 3 parts, flat cattail leaf fan 1 part, magnificent Ramulus et Folium Schoepfiae chinesis 3 parts, Ramulus et Folium Reinwardtiae Trigynae 2 parts, sinopimelodendron kwangsiense 3 parts, Cangshan Herba corydalis racemosae 5 parts, Cortex Araliae Elatae Radicis 1 part, Herba saussureae nigrescentis 1, thorn coriander 3 parts, Flos Bauhiniae Variegatae 2 parts, Herba Carpesii Cernui 1 part, Adinandra millettii 2 parts, Caulis Marsdeniae tinctoriae 5 parts, Meehania urticaefolia 4 parts, Eriophyton wallichii Benth 2 parts, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain 3 parts.
Treat a preparation method for the pharmaceutical composition of hepatopathy, comprise the following steps:
(1) the Pueraria lobota Bud root of formula ratio is got, Semen Avenae fatuae, large lip Radix seu Herba Pedicularis, flat cattail leaf fan, China's Ramulus et Folium Schoepfiae chinesis, sinopimelodendron kwangsiense, Cangshan Herba corydalis racemosae, Cortex Araliae Elatae Radicis, Herba saussureae nigrescentis, Flos Bauhiniae Variegatae, Adinandra millettii, Caulis Marsdeniae tinctoriae, Meehania urticaefolia, Eriophyton wallichii Benth, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain, add the water of 8 times of medical material gross weight, 40 minutes are soaked in 40 DEG C of constant temperature, be placed in boiler and decoct extraction 1 time, each 1 hour, filter, obtain and merging filtrate, filtrate is evaporated to the extractum that relative density is 1.25 at 70 DEG C, adding ethanol to alcohol content is 80%v/v, leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, obtain active components A, for subsequent use,
(2) thorn coriander, the Herba Carpesii Cernui of formula ratio is got, the volume by volume concentration adding medical material gross weight 1 times is the alcohol dipping 30 hours of 60%, then with volume by volume concentration be 50% ethanol carry out percolation with the speed accounting for raw material total weight parts 0.5% per minute, collect the percolate being equivalent to medical material gross weight 3 times amount, reclaim ethanol, be evaporated to 1 times that is equivalent to medical material gross weight, filter, obtain active component B, for subsequent use;
(3) Ramulus et Folium Reinwardtiae Trigynae of formula ratio is got, with the water soaking 10min that the temperature relative to its weight 20 times is 85 DEG C, filter, under filtrate reduced in volume to 70 DEG C environment, relative density is the extractum of 1.25, spray dried becomes extract powder, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s, obtains active component C, for subsequent use;
(4) get the Radix Scutellariae of formula ratio, Rhizoma Coptidis, Cortex Phellodendri, Radix Gentianae, Cortex Fraxini, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Menthae, Flos Chrysanthemi Indici, dry, pulverize, add the soak by water 1h of medical material gross weight 6 times amount, filter; Filtering residue adds the soak by water 0.5h of medical material gross weight 5 times amount, filters; Merge twice filtrate, being evaporated to relative density under 70 DEG C of environment is the extractum of 1.25, dry, pulverize rear mistake 80 mesh sieve, obtains active component D, for subsequent use;
(5) 200 parts of waters for injection are got, above-mentioned active components A, active component B, active component C, active component D are dissolved in wherein, add vitamin B, vitamin C, penicillin, add the emulsifying agent, the antiseptic of 0.05%, the antioxidant of 0.03% that are equivalent to described water for injection weight 0.08% again, described emulsifying agent is sodium lauryl sulphate, described antiseptic is for being parabens, and described antioxidant is BHT; And be placed in ultrasonic disperse equipment and carry out supersound process 10s with the frequency of 40Hz, namely obtain the drug composition oral liquid for the treatment of hepatopathy.
Embodiment 2:
Treat a pharmaceutical composition for hepatopathy, its material composition is by weight: Pueraria lobota Bud root 6 parts, Semen Avenae fatuae 6 parts, large lip Radix seu Herba Pedicularis 5 parts, flat cattail leaf fan 2 parts, magnificent Ramulus et Folium Schoepfiae chinesis 6.5 parts, Ramulus et Folium Reinwardtiae Trigynae 4.5 parts, sinopimelodendron kwangsiense 4.5 parts, Cangshan Herba corydalis racemosae 7 parts, Cortex Araliae Elatae Radicis 2 parts, Herba saussureae nigrescentis 3 parts, thorn coriander 4.5 parts, Flos Bauhiniae Variegatae 5 parts, Herba Carpesii Cernui 5 parts, Adinandra millettii 6 parts, Caulis Marsdeniae tinctoriae 7.5 parts, Meehania urticaefolia 6.5 parts, Eriophyton wallichii Benth 3.5 parts, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain 5 parts.
Treat a preparation method for the pharmaceutical composition of hepatopathy, comprise the following steps:
(1) the Pueraria lobota Bud root of formula ratio is got, Semen Avenae fatuae, large lip Radix seu Herba Pedicularis, flat cattail leaf fan, China's Ramulus et Folium Schoepfiae chinesis, sinopimelodendron kwangsiense, Cangshan Herba corydalis racemosae, Cortex Araliae Elatae Radicis, Herba saussureae nigrescentis, Flos Bauhiniae Variegatae, Adinandra millettii, Caulis Marsdeniae tinctoriae, Meehania urticaefolia, Eriophyton wallichii Benth, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain, add the water of 9 times of medical material gross weight, 45 minutes are soaked in 42.5 DEG C of constant temperature, be placed in boiler and decoct extraction 2 times, each 2 hours, filter, obtain and merging filtrate, filtrate is evaporated to the extractum that relative density is 1.30 at 70 DEG C, adding ethanol to alcohol content is 85%v/v, leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, obtain active components A, for subsequent use,
(2) thorn coriander, the Herba Carpesii Cernui of formula ratio is got, the volume by volume concentration adding medical material gross weight 1.5 times is the alcohol dipping 35 hours of 65%, then with volume by volume concentration be 55% ethanol carry out percolation with the speed accounting for raw material total weight parts 0.6% per minute, collect the percolate being equivalent to medical material gross weight 6.5 times amount, reclaim ethanol, be evaporated to 1.3 times that are equivalent to medical material gross weight, filter, obtain active component B, for subsequent use;
(3) Ramulus et Folium Reinwardtiae Trigynae of formula ratio is got, with the water soaking 12.5min that the temperature relative to its weight 25 times is 90 DEG C, filter, under filtrate reduced in volume to 70 DEG C environment, relative density is the extractum of 1.30, spray dried becomes extract powder, spray drying condition is: inlet temperature is 110 DEG C, and leaving air temp is 85 DEG C, and temperature of charge is 80 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s, obtains active component C, for subsequent use;
(4) get the Radix Scutellariae of formula ratio, Rhizoma Coptidis, Cortex Phellodendri, Radix Gentianae, Cortex Fraxini, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Menthae, Flos Chrysanthemi Indici, dry, pulverize, add the soak by water 1.25h of medical material gross weight 8 times amount, filter; Filtering residue adds the soak by water 0.75h of medical material gross weight 5.5 times amount, filters; Merge twice filtrate, being evaporated to relative density under 70 DEG C of environment is the extractum of 1.30, dry, pulverize rear mistake 90 mesh sieve, obtains active component D, for subsequent use;
(5) 240 parts of waters for injection are got, above-mentioned active components A, active component B, active component C, active component D are dissolved in wherein, add vitamin B, vitamin C, penicillin, add the emulsifying agent, the antiseptic of 0.065%, the antioxidant of 0.045% that are equivalent to described water for injection weight 0.09% again, described emulsifying agent is sucrose monolaurate, described antiseptic is for being benzoate, and described antioxidant is sodium sulfite; And be placed in ultrasonic disperse equipment and carry out supersound process 15s with the frequency of 50Hz, namely obtain the drug composition oral liquid for the treatment of hepatopathy.
Embodiment 3:
Treat a pharmaceutical composition for hepatopathy, its material composition is by weight: Pueraria lobota Bud root 7 parts, Semen Avenae fatuae 8 parts, large lip Radix seu Herba Pedicularis 7 parts, flat cattail leaf fan 3 parts, magnificent Ramulus et Folium Schoepfiae chinesis 10 parts, Ramulus et Folium Reinwardtiae Trigynae 7 parts, sinopimelodendron kwangsiense 6 parts, Cangshan Herba corydalis racemosae 9 parts, Cortex Araliae Elatae Radicis 3 parts, Herba saussureae nigrescentis 5, thorn coriander 6 parts, Flos Bauhiniae Variegatae 8 parts, Herba Carpesii Cernui 9 parts, Adinandra millettii 10 parts, Caulis Marsdeniae tinctoriae 10 parts, Meehania urticaefolia 9 parts, Eriophyton wallichii Benth 5 parts, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain 7 parts.
Treat a preparation method for the pharmaceutical composition of hepatopathy, comprise the following steps:
(1) the Pueraria lobota Bud root of formula ratio is got, Semen Avenae fatuae, large lip Radix seu Herba Pedicularis, flat cattail leaf fan, China's Ramulus et Folium Schoepfiae chinesis, sinopimelodendron kwangsiense, Cangshan Herba corydalis racemosae, Cortex Araliae Elatae Radicis, Herba saussureae nigrescentis, Flos Bauhiniae Variegatae, Adinandra millettii, Caulis Marsdeniae tinctoriae, Meehania urticaefolia, Eriophyton wallichii Benth, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain, add the water of 10 times of medical material gross weight, 50 minutes are soaked in 45 DEG C of constant temperature, be placed in boiler and decoct extraction 3 times, each 3 hours, filter, obtain and merging filtrate, filtrate is evaporated to the extractum that relative density is 1.35 at 70 DEG C, adding ethanol to alcohol content is 90%v/v, leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, obtain active components A, for subsequent use,
(2) thorn coriander, the Herba Carpesii Cernui of formula ratio is got, the volume by volume concentration adding medical material gross weight 2 times is the alcohol dipping 40 hours of 70%, then with volume by volume concentration be 60% ethanol carry out percolation with the speed accounting for raw material total weight parts 0.7% per minute, collect the percolate being equivalent to medical material gross weight 10 times amount, reclaim ethanol, be evaporated to 1.6 times that are equivalent to medical material gross weight, filter, obtain active component B, for subsequent use;
(3) Ramulus et Folium Reinwardtiae Trigynae of formula ratio is got, with the water soaking 15min that the temperature relative to its weight 30 times is 95 DEG C, filter, under filtrate reduced in volume to 70 DEG C environment, relative density is the extractum of 1.35, spray dried becomes extract powder, spray drying condition is: inlet temperature is 120 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 90 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 10ml/s, obtains active component C, for subsequent use;
(4) get the Radix Scutellariae of formula ratio, Rhizoma Coptidis, Cortex Phellodendri, Radix Gentianae, Cortex Fraxini, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Menthae, Flos Chrysanthemi Indici, dry, pulverize, add the soak by water 1.5h of medical material gross weight 10 times amount, filter; Filtering residue adds the soak by water 1.0h of medical material gross weight 6 times amount, filters; Merge twice filtrate, being evaporated to relative density under 70 DEG C of environment is the extractum of 1.35, dry, pulverize rear mistake 100 mesh sieve, obtains active component D, for subsequent use;
(5) 280 parts of waters for injection are got, above-mentioned active components A, active component B, active component C, active component D are dissolved in wherein, add vitamin B, vitamin C, penicillin, add the emulsifying agent, the antiseptic of 0.08%, the antioxidant of 0.06% that are equivalent to described water for injection weight 0.1% again, described emulsifying agent is that fatty acid Pyrusussuriensis is smooth, described antiseptic is for being sorbic acid, and described antioxidant is sodium pyrosulfite; And be placed in ultrasonic disperse equipment and carry out supersound process 20s with the frequency of 60Hz, namely obtain the drug composition oral liquid for the treatment of hepatopathy.
Embodiment 4:
Treat a pharmaceutical composition for hepatopathy, its material composition is by weight: Pueraria lobota Bud root 5 parts, Semen Avenae fatuae 4 parts, large lip Radix seu Herba Pedicularis 3 parts, flat cattail leaf fan 1 part, magnificent Ramulus et Folium Schoepfiae chinesis 3 parts, Ramulus et Folium Reinwardtiae Trigynae 2 parts, sinopimelodendron kwangsiense 3 parts, Cangshan Herba corydalis racemosae 5 parts, Cortex Araliae Elatae Radicis 1 part, Herba saussureae nigrescentis 1, thorn coriander 3 parts, Flos Bauhiniae Variegatae 2 parts, Herba Carpesii Cernui 1 part, Adinandra millettii 2 parts, Caulis Marsdeniae tinctoriae 5 parts, Meehania urticaefolia 4 parts, Eriophyton wallichii Benth 2 parts, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain 3 parts; Also comprise: Radix Scutellariae 0.2 part, Rhizoma Coptidis 0.1 part, Cortex Phellodendri 0.3 part, Radix Gentianae 0.1 part, Cortex Fraxini 0.1 part, Radix Sophorae Flavescentis 0.3 part, Herba Taraxaci 0.1 part, Herba Menthae 0.1 part, Flos Chrysanthemi Indici 0.1 part.
Treat a preparation method for the pharmaceutical composition of hepatopathy, comprise the following steps:
(1) the Pueraria lobota Bud root of formula ratio is got, Semen Avenae fatuae, large lip Radix seu Herba Pedicularis, flat cattail leaf fan, China's Ramulus et Folium Schoepfiae chinesis, sinopimelodendron kwangsiense, Cangshan Herba corydalis racemosae, Cortex Araliae Elatae Radicis, Herba saussureae nigrescentis, Flos Bauhiniae Variegatae, Adinandra millettii, Caulis Marsdeniae tinctoriae, Meehania urticaefolia, Eriophyton wallichii Benth, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain, add the water of 8 times of medical material gross weight, 40 minutes are soaked in 40 DEG C of constant temperature, be placed in boiler and decoct extraction 1 time, each 1 hour, filter, obtain and merging filtrate, filtrate is evaporated to the extractum that relative density is 1.25 at 70 DEG C, adding ethanol to alcohol content is 80%v/v, leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, obtain active components A, for subsequent use,
(2) thorn coriander, the Herba Carpesii Cernui of formula ratio is got, the volume by volume concentration adding medical material gross weight 1 times is the alcohol dipping 30 hours of 60%, then with volume by volume concentration be 50% ethanol carry out percolation with the speed accounting for raw material total weight parts 0.5% per minute, collect the percolate being equivalent to medical material gross weight 3 times amount, reclaim ethanol, be evaporated to 1 times that is equivalent to medical material gross weight, filter, obtain active component B, for subsequent use;
(3) Ramulus et Folium Reinwardtiae Trigynae of formula ratio is got, with the water soaking 10min that the temperature relative to its weight 20 times is 85 DEG C, filter, under filtrate reduced in volume to 70 DEG C environment, relative density is the extractum of 1.25, spray dried becomes extract powder, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s, obtains active component C, for subsequent use;
(4) get the Radix Scutellariae of formula ratio, Rhizoma Coptidis, Cortex Phellodendri, Radix Gentianae, Cortex Fraxini, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Menthae, Flos Chrysanthemi Indici, dry, pulverize, add the soak by water 1h of medical material gross weight 6 times amount, filter; Filtering residue adds the soak by water 0.5h of medical material gross weight 5 times amount, filters; Merge twice filtrate, being evaporated to relative density under 70 DEG C of environment is the extractum of 1.25, dry, pulverize rear mistake 80 mesh sieve, obtains active component D, for subsequent use;
(5) 200 parts of waters for injection are got, above-mentioned active components A, active component B, active component C, active component D are dissolved in wherein, add vitamin B, vitamin C, penicillin, add the emulsifying agent, the antiseptic of 0.05%, the antioxidant of 0.03% that are equivalent to described water for injection weight 0.08% again, described emulsifying agent is sodium lauryl sulphate, described antiseptic is for being parabens, and described antioxidant is BHT; And be placed in ultrasonic disperse equipment and carry out supersound process 10s with the frequency of 40Hz, namely obtain the drug composition oral liquid for the treatment of hepatopathy.
Embodiment 5:
Treat a pharmaceutical composition for hepatopathy, its material composition is by weight: Pueraria lobota Bud root 6 parts, Semen Avenae fatuae 6 parts, large lip Radix seu Herba Pedicularis 5 parts, flat cattail leaf fan 2 parts, magnificent Ramulus et Folium Schoepfiae chinesis 6.5 parts, Ramulus et Folium Reinwardtiae Trigynae 4.5 parts, sinopimelodendron kwangsiense 4.5 parts, Cangshan Herba corydalis racemosae 7 parts, Cortex Araliae Elatae Radicis 2 parts, Herba saussureae nigrescentis 3 parts, thorn coriander 4.5 parts, Flos Bauhiniae Variegatae 5 parts, Herba Carpesii Cernui 5 parts, Adinandra millettii 6 parts, Caulis Marsdeniae tinctoriae 7.5 parts, Meehania urticaefolia 6.5 parts, Eriophyton wallichii Benth 3.5 parts, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain 5 parts; Also comprise: Radix Scutellariae 0.45 part, Rhizoma Coptidis 0.2 part, Cortex Phellodendri 0.5 part, Radix Gentianae 0.2 part, Cortex Fraxini 0.2 part, Radix Sophorae Flavescentis 0.5 part, Herba Taraxaci 0.2 part, Herba Menthae 0.2 part, Flos Chrysanthemi Indici 0.2 part.
Treat a preparation method for the pharmaceutical composition of hepatopathy, comprise the following steps:
(1) the Pueraria lobota Bud root of formula ratio is got, Semen Avenae fatuae, large lip Radix seu Herba Pedicularis, flat cattail leaf fan, China's Ramulus et Folium Schoepfiae chinesis, sinopimelodendron kwangsiense, Cangshan Herba corydalis racemosae, Cortex Araliae Elatae Radicis, Herba saussureae nigrescentis, Flos Bauhiniae Variegatae, Adinandra millettii, Caulis Marsdeniae tinctoriae, Meehania urticaefolia, Eriophyton wallichii Benth, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain, add the water of 9 times of medical material gross weight, 45 minutes are soaked in 42.5 DEG C of constant temperature, be placed in boiler and decoct extraction 2 times, each 2 hours, filter, obtain and merging filtrate, filtrate is evaporated to the extractum that relative density is 1.30 at 70 DEG C, adding ethanol to alcohol content is 85%v/v, leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, obtain active components A, for subsequent use,
(2) thorn coriander, the Herba Carpesii Cernui of formula ratio is got, the volume by volume concentration adding medical material gross weight 1.5 times is the alcohol dipping 35 hours of 65%, then with volume by volume concentration be 55% ethanol carry out percolation with the speed accounting for raw material total weight parts 0.6% per minute, collect the percolate being equivalent to medical material gross weight 6.5 times amount, reclaim ethanol, be evaporated to 1.3 times that are equivalent to medical material gross weight, filter, obtain active component B, for subsequent use;
(3) Ramulus et Folium Reinwardtiae Trigynae of formula ratio is got, with the water soaking 12.5min that the temperature relative to its weight 25 times is 90 DEG C, filter, under filtrate reduced in volume to 70 DEG C environment, relative density is the extractum of 1.30, spray dried becomes extract powder, spray drying condition is: inlet temperature is 110 DEG C, and leaving air temp is 85 DEG C, and temperature of charge is 80 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s, obtains active component C, for subsequent use;
(4) get the Radix Scutellariae of formula ratio, Rhizoma Coptidis, Cortex Phellodendri, Radix Gentianae, Cortex Fraxini, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Menthae, Flos Chrysanthemi Indici, dry, pulverize, add the soak by water 1.25h of medical material gross weight 8 times amount, filter; Filtering residue adds the soak by water 0.75h of medical material gross weight 5.5 times amount, filters; Merge twice filtrate, being evaporated to relative density under 70 DEG C of environment is the extractum of 1.30, dry, pulverize rear mistake 90 mesh sieve, obtains active component D, for subsequent use;
(5) 240 parts of waters for injection are got, above-mentioned active components A, active component B, active component C, active component D are dissolved in wherein, add vitamin B, vitamin C, penicillin, add the emulsifying agent, the antiseptic of 0.065%, the antioxidant of 0.045% that are equivalent to described water for injection weight 0.09% again, described emulsifying agent is sucrose monolaurate, described antiseptic is for being benzoate, and described antioxidant is sodium sulfite; And be placed in ultrasonic disperse equipment and carry out supersound process 15s with the frequency of 50Hz, namely obtain the drug composition oral liquid for the treatment of hepatopathy.
Embodiment 6:
Treat a pharmaceutical composition for hepatopathy, its material composition is by weight: Pueraria lobota Bud root 7 parts, Semen Avenae fatuae 8 parts, large lip Radix seu Herba Pedicularis 7 parts, flat cattail leaf fan 3 parts, magnificent Ramulus et Folium Schoepfiae chinesis 10 parts, Ramulus et Folium Reinwardtiae Trigynae 7 parts, sinopimelodendron kwangsiense 6 parts, Cangshan Herba corydalis racemosae 9 parts, Cortex Araliae Elatae Radicis 3 parts, Herba saussureae nigrescentis 5, thorn coriander 6 parts, Flos Bauhiniae Variegatae 8 parts, Herba Carpesii Cernui 9 parts, Adinandra millettii 10 parts, Caulis Marsdeniae tinctoriae 10 parts, Meehania urticaefolia 9 parts, Eriophyton wallichii Benth 5 parts, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain 7 parts; Also comprise: Radix Scutellariae 0.7 part, Rhizoma Coptidis 0.3 part, Cortex Phellodendri 0.7 part, Radix Gentianae 0.3 part, Cortex Fraxini 0.3 part, Radix Sophorae Flavescentis 0.7 part, Herba Taraxaci 0.3 part, Herba Menthae 0.3 part, Flos Chrysanthemi Indici 0.3 part.
Treat a preparation method for the pharmaceutical composition of hepatopathy, comprise the following steps:
(1) the Pueraria lobota Bud root of formula ratio is got, Semen Avenae fatuae, large lip Radix seu Herba Pedicularis, flat cattail leaf fan, China's Ramulus et Folium Schoepfiae chinesis, sinopimelodendron kwangsiense, Cangshan Herba corydalis racemosae, Cortex Araliae Elatae Radicis, Herba saussureae nigrescentis, Flos Bauhiniae Variegatae, Adinandra millettii, Caulis Marsdeniae tinctoriae, Meehania urticaefolia, Eriophyton wallichii Benth, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain, add the water of 10 times of medical material gross weight, 50 minutes are soaked in 45 DEG C of constant temperature, be placed in boiler and decoct extraction 3 times, each 3 hours, filter, obtain and merging filtrate, filtrate is evaporated to the extractum that relative density is 1.35 at 70 DEG C, adding ethanol to alcohol content is 90%v/v, leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, obtain active components A, for subsequent use,
(2) thorn coriander, the Herba Carpesii Cernui of formula ratio is got, the volume by volume concentration adding medical material gross weight 2 times is the alcohol dipping 40 hours of 70%, then with volume by volume concentration be 60% ethanol carry out percolation with the speed accounting for raw material total weight parts 0.7% per minute, collect the percolate being equivalent to medical material gross weight 10 times amount, reclaim ethanol, be evaporated to 1.6 times that are equivalent to medical material gross weight, filter, obtain active component B, for subsequent use;
(3) Ramulus et Folium Reinwardtiae Trigynae of formula ratio is got, with the water soaking 15min that the temperature relative to its weight 30 times is 95 DEG C, filter, under filtrate reduced in volume to 70 DEG C environment, relative density is the extractum of 1.35, spray dried becomes extract powder, spray drying condition is: inlet temperature is 120 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 90 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 10ml/s, obtains active component C, for subsequent use;
(4) get the Radix Scutellariae of formula ratio, Rhizoma Coptidis, Cortex Phellodendri, Radix Gentianae, Cortex Fraxini, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Menthae, Flos Chrysanthemi Indici, dry, pulverize, add the soak by water 1.5h of medical material gross weight 10 times amount, filter; Filtering residue adds the soak by water 1.0h of medical material gross weight 6 times amount, filters; Merge twice filtrate, being evaporated to relative density under 70 DEG C of environment is the extractum of 1.35, dry, pulverize rear mistake 100 mesh sieve, obtains active component D, for subsequent use;
(5) 280 parts of waters for injection are got, above-mentioned active components A, active component B, active component C, active component D are dissolved in wherein, add vitamin B, vitamin C, penicillin, add the emulsifying agent, the antiseptic of 0.08%, the antioxidant of 0.06% that are equivalent to described water for injection weight 0.1% again, described emulsifying agent is that fatty acid Pyrusussuriensis is smooth, described antiseptic is for being sorbic acid, and described antioxidant is sodium pyrosulfite; And be placed in ultrasonic disperse equipment and carry out supersound process 20s with the frequency of 60Hz, namely obtain the drug composition oral liquid for the treatment of hepatopathy.
Embodiment 7:
Treat a pharmaceutical composition for hepatopathy, its material composition is by weight: Pueraria lobota Bud root 5 parts, Semen Avenae fatuae 4 parts, large lip Radix seu Herba Pedicularis 3 parts, flat cattail leaf fan 1 part, magnificent Ramulus et Folium Schoepfiae chinesis 3 parts, Ramulus et Folium Reinwardtiae Trigynae 2 parts, sinopimelodendron kwangsiense 3 parts, Cangshan Herba corydalis racemosae 5 parts, Cortex Araliae Elatae Radicis 1 part, Herba saussureae nigrescentis 1, thorn coriander 3 parts, Flos Bauhiniae Variegatae 2 parts, Herba Carpesii Cernui 1 part, Adinandra millettii 2 parts, Caulis Marsdeniae tinctoriae 5 parts, Meehania urticaefolia 4 parts, Eriophyton wallichii Benth 2 parts, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain 3 parts; Also comprise: Radix Scutellariae 0.2 part, Rhizoma Coptidis 0.1 part, Cortex Phellodendri 0.3 part, Radix Gentianae 0.1 part, Cortex Fraxini 0.1 part, Radix Sophorae Flavescentis 0.3 part, Herba Taraxaci 0.1 part, Herba Menthae 0.1 part, Flos Chrysanthemi Indici 0.1 part; Also comprise vitamin B 0.01 part, vitamin C 0.01 part, penicillin 0.0001 part.
Treat a preparation method for the pharmaceutical composition of hepatopathy, comprise the following steps:
(1) the Pueraria lobota Bud root of formula ratio is got, Semen Avenae fatuae, large lip Radix seu Herba Pedicularis, flat cattail leaf fan, China's Ramulus et Folium Schoepfiae chinesis, sinopimelodendron kwangsiense, Cangshan Herba corydalis racemosae, Cortex Araliae Elatae Radicis, Herba saussureae nigrescentis, Flos Bauhiniae Variegatae, Adinandra millettii, Caulis Marsdeniae tinctoriae, Meehania urticaefolia, Eriophyton wallichii Benth, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain, add the water of 8 times of medical material gross weight, 40 minutes are soaked in 40 DEG C of constant temperature, be placed in boiler and decoct extraction 1 time, each 1 hour, filter, obtain and merging filtrate, filtrate is evaporated to the extractum that relative density is 1.25 at 70 DEG C, adding ethanol to alcohol content is 80%v/v, leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, obtain active components A, for subsequent use,
(2) thorn coriander, the Herba Carpesii Cernui of formula ratio is got, the volume by volume concentration adding medical material gross weight 1 times is the alcohol dipping 30 hours of 60%, then with volume by volume concentration be 50% ethanol carry out percolation with the speed accounting for raw material total weight parts 0.5% per minute, collect the percolate being equivalent to medical material gross weight 3 times amount, reclaim ethanol, be evaporated to 1 times that is equivalent to medical material gross weight, filter, obtain active component B, for subsequent use;
(3) Ramulus et Folium Reinwardtiae Trigynae of formula ratio is got, with the water soaking 10min that the temperature relative to its weight 20 times is 85 DEG C, filter, under filtrate reduced in volume to 70 DEG C environment, relative density is the extractum of 1.25, spray dried becomes extract powder, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s, obtains active component C, for subsequent use;
(4) get the Radix Scutellariae of formula ratio, Rhizoma Coptidis, Cortex Phellodendri, Radix Gentianae, Cortex Fraxini, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Menthae, Flos Chrysanthemi Indici, dry, pulverize, add the soak by water 1h of medical material gross weight 6 times amount, filter; Filtering residue adds the soak by water 0.5h of medical material gross weight 5 times amount, filters; Merge twice filtrate, being evaporated to relative density under 70 DEG C of environment is the extractum of 1.25, dry, pulverize rear mistake 80 mesh sieve, obtains active component D, for subsequent use;
(5) 200 parts of waters for injection are got, above-mentioned active components A, active component B, active component C, active component D are dissolved in wherein, add vitamin B, vitamin C, penicillin, add the emulsifying agent, the antiseptic of 0.05%, the antioxidant of 0.03% that are equivalent to described water for injection weight 0.08% again, described emulsifying agent is sodium lauryl sulphate, described antiseptic is for being parabens, and described antioxidant is BHT; And be placed in ultrasonic disperse equipment and carry out supersound process 10s with the frequency of 40Hz, namely obtain the drug composition oral liquid for the treatment of hepatopathy.
Embodiment 8:
Treat a pharmaceutical composition for hepatopathy, its material composition is by weight: Pueraria lobota Bud root 6 parts, Semen Avenae fatuae 6 parts, large lip Radix seu Herba Pedicularis 5 parts, flat cattail leaf fan 2 parts, magnificent Ramulus et Folium Schoepfiae chinesis 6.5 parts, Ramulus et Folium Reinwardtiae Trigynae 4.5 parts, sinopimelodendron kwangsiense 4.5 parts, Cangshan Herba corydalis racemosae 7 parts, Cortex Araliae Elatae Radicis 2 parts, Herba saussureae nigrescentis 3 parts, thorn coriander 4.5 parts, Flos Bauhiniae Variegatae 5 parts, Herba Carpesii Cernui 5 parts, Adinandra millettii 6 parts, Caulis Marsdeniae tinctoriae 7.5 parts, Meehania urticaefolia 6.5 parts, Eriophyton wallichii Benth 3.5 parts, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain 5 parts; Also comprise: Radix Scutellariae 0.45 part, Rhizoma Coptidis 0.2 part, Cortex Phellodendri 0.5 part, Radix Gentianae 0.2 part, Cortex Fraxini 0.2 part, Radix Sophorae Flavescentis 0.5 part, Herba Taraxaci 0.2 part, Herba Menthae 0.2 part, Flos Chrysanthemi Indici 0.2 part; Also comprise vitamin B 0.02 part, vitamin C 0.025 part, penicillin 0.0002 part.
Treat a preparation method for the pharmaceutical composition of hepatopathy, comprise the following steps:
(1) the Pueraria lobota Bud root of formula ratio is got, Semen Avenae fatuae, large lip Radix seu Herba Pedicularis, flat cattail leaf fan, China's Ramulus et Folium Schoepfiae chinesis, sinopimelodendron kwangsiense, Cangshan Herba corydalis racemosae, Cortex Araliae Elatae Radicis, Herba saussureae nigrescentis, Flos Bauhiniae Variegatae, Adinandra millettii, Caulis Marsdeniae tinctoriae, Meehania urticaefolia, Eriophyton wallichii Benth, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain, add the water of 9 times of medical material gross weight, 45 minutes are soaked in 42.5 DEG C of constant temperature, be placed in boiler and decoct extraction 2 times, each 2 hours, filter, obtain and merging filtrate, filtrate is evaporated to the extractum that relative density is 1.30 at 70 DEG C, adding ethanol to alcohol content is 85%v/v, leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, obtain active components A, for subsequent use,
(2) thorn coriander, the Herba Carpesii Cernui of formula ratio is got, the volume by volume concentration adding medical material gross weight 1.5 times is the alcohol dipping 35 hours of 65%, then with volume by volume concentration be 55% ethanol carry out percolation with the speed accounting for raw material total weight parts 0.6% per minute, collect the percolate being equivalent to medical material gross weight 6.5 times amount, reclaim ethanol, be evaporated to 1.3 times that are equivalent to medical material gross weight, filter, obtain active component B, for subsequent use;
(3) Ramulus et Folium Reinwardtiae Trigynae of formula ratio is got, with the water soaking 12.5min that the temperature relative to its weight 25 times is 90 DEG C, filter, under filtrate reduced in volume to 70 DEG C environment, relative density is the extractum of 1.30, spray dried becomes extract powder, spray drying condition is: inlet temperature is 110 DEG C, and leaving air temp is 85 DEG C, and temperature of charge is 80 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s, obtains active component C, for subsequent use;
(4) get the Radix Scutellariae of formula ratio, Rhizoma Coptidis, Cortex Phellodendri, Radix Gentianae, Cortex Fraxini, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Menthae, Flos Chrysanthemi Indici, dry, pulverize, add the soak by water 1.25h of medical material gross weight 8 times amount, filter; Filtering residue adds the soak by water 0.75h of medical material gross weight 5.5 times amount, filters; Merge twice filtrate, being evaporated to relative density under 70 DEG C of environment is the extractum of 1.30, dry, pulverize rear mistake 90 mesh sieve, obtains active component D, for subsequent use;
(5) 240 parts of waters for injection are got, above-mentioned active components A, active component B, active component C, active component D are dissolved in wherein, add vitamin B, vitamin C, penicillin, add the emulsifying agent, the antiseptic of 0.065%, the antioxidant of 0.045% that are equivalent to described water for injection weight 0.09% again, described emulsifying agent is sucrose monolaurate, described antiseptic is for being benzoate, and described antioxidant is sodium sulfite; And be placed in ultrasonic disperse equipment and carry out supersound process 15s with the frequency of 50Hz, namely obtain the drug composition oral liquid for the treatment of hepatopathy.
Embodiment 9:
Treat a pharmaceutical composition for hepatopathy, its material composition is by weight: Pueraria lobota Bud root 7 parts, Semen Avenae fatuae 8 parts, large lip Radix seu Herba Pedicularis 7 parts, flat cattail leaf fan 3 parts, magnificent Ramulus et Folium Schoepfiae chinesis 10 parts, Ramulus et Folium Reinwardtiae Trigynae 7 parts, sinopimelodendron kwangsiense 6 parts, Cangshan Herba corydalis racemosae 9 parts, Cortex Araliae Elatae Radicis 3 parts, Herba saussureae nigrescentis 5, thorn coriander 6 parts, Flos Bauhiniae Variegatae 8 parts, Herba Carpesii Cernui 9 parts, Adinandra millettii 10 parts, Caulis Marsdeniae tinctoriae 10 parts, Meehania urticaefolia 9 parts, Eriophyton wallichii Benth 5 parts, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain 7 parts; Also comprise: Radix Scutellariae 0.7 part, Rhizoma Coptidis 0.3 part, Cortex Phellodendri 0.7 part, Radix Gentianae 0.3 part, Cortex Fraxini 0.3 part, Radix Sophorae Flavescentis 0.7 part, Herba Taraxaci 0.3 part, Herba Menthae 0.3 part, Flos Chrysanthemi Indici 0.3 part; Also comprise vitamin B 0.03 part, vitamin C 0.04 part, penicillin 0.0003 part.
Treat a preparation method for the pharmaceutical composition of hepatopathy, comprise the following steps:
(1) the Pueraria lobota Bud root of formula ratio is got, Semen Avenae fatuae, large lip Radix seu Herba Pedicularis, flat cattail leaf fan, China's Ramulus et Folium Schoepfiae chinesis, sinopimelodendron kwangsiense, Cangshan Herba corydalis racemosae, Cortex Araliae Elatae Radicis, Herba saussureae nigrescentis, Flos Bauhiniae Variegatae, Adinandra millettii, Caulis Marsdeniae tinctoriae, Meehania urticaefolia, Eriophyton wallichii Benth, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain, add the water of 10 times of medical material gross weight, 50 minutes are soaked in 45 DEG C of constant temperature, be placed in boiler and decoct extraction 3 times, each 3 hours, filter, obtain and merging filtrate, filtrate is evaporated to the extractum that relative density is 1.35 at 70 DEG C, adding ethanol to alcohol content is 90%v/v, leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, obtain active components A, for subsequent use,
(2) thorn coriander, the Herba Carpesii Cernui of formula ratio is got, the volume by volume concentration adding medical material gross weight 2 times is the alcohol dipping 40 hours of 70%, then with volume by volume concentration be 60% ethanol carry out percolation with the speed accounting for raw material total weight parts 0.7% per minute, collect the percolate being equivalent to medical material gross weight 10 times amount, reclaim ethanol, be evaporated to 1.6 times that are equivalent to medical material gross weight, filter, obtain active component B, for subsequent use;
(3) Ramulus et Folium Reinwardtiae Trigynae of formula ratio is got, with the water soaking 15min that the temperature relative to its weight 30 times is 95 DEG C, filter, under filtrate reduced in volume to 70 DEG C environment, relative density is the extractum of 1.35, spray dried becomes extract powder, spray drying condition is: inlet temperature is 120 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 90 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 10ml/s, obtains active component C, for subsequent use;
(4) get the Radix Scutellariae of formula ratio, Rhizoma Coptidis, Cortex Phellodendri, Radix Gentianae, Cortex Fraxini, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Menthae, Flos Chrysanthemi Indici, dry, pulverize, add the soak by water 1.5h of medical material gross weight 10 times amount, filter; Filtering residue adds the soak by water 1.0h of medical material gross weight 6 times amount, filters; Merge twice filtrate, being evaporated to relative density under 70 DEG C of environment is the extractum of 1.35, dry, pulverize rear mistake 100 mesh sieve, obtains active component D, for subsequent use;
(5) 280 parts of waters for injection are got, above-mentioned active components A, active component B, active component C, active component D are dissolved in wherein, add vitamin B, vitamin C, penicillin, add the emulsifying agent, the antiseptic of 0.08%, the antioxidant of 0.06% that are equivalent to described water for injection weight 0.1% again, described emulsifying agent is that fatty acid Pyrusussuriensis is smooth, described antiseptic is for being sorbic acid, and described antioxidant is sodium pyrosulfite; And be placed in ultrasonic disperse equipment and carry out supersound process 20s with the frequency of 60Hz, namely obtain the drug composition oral liquid for the treatment of hepatopathy.
Clinical practice: the present invention draws through clinical experiment: for icterohepatitis 300 example, its cure rate is 100%; To the disease such as liver cirrhosis, hepatic ascites 170 example, its cure rate reaches 80%, and what take a turn for the better to some extent is 20%.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (10)
1. treat the pharmaceutical composition of hepatopathy for one kind, it is characterized in that, its material composition is by weight: Pueraria lobota Bud root 5 ~ 7 parts, Semen Avenae fatuae 4 ~ 8 parts, large lip Radix seu Herba Pedicularis 3 ~ 7 parts, flat cattail leaf fan 1 ~ 3 part, magnificent Ramulus et Folium Schoepfiae chinesis 3 ~ 10 parts, Ramulus et Folium Reinwardtiae Trigynae 2 ~ 7 parts, sinopimelodendron kwangsiense 3 ~ 6 parts, Cangshan Herba corydalis racemosae 5 ~ 9 parts, Cortex Araliae Elatae Radicis 1 ~ 3 part, Herba saussureae nigrescentis 1 ~ 5, thorn coriander 3 ~ 6 parts, Flos Bauhiniae Variegatae 2 ~ 8 parts, Herba Carpesii Cernui 1 ~ 9 part, Adinandra millettii 2 ~ 10 parts, Caulis Marsdeniae tinctoriae 5 ~ 10 parts, Meehania urticaefolia 4 ~ 9 parts, Eriophyton wallichii Benth 2 ~ 5 parts, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain 3 ~ 7 parts.
2. a kind of pharmaceutical composition for the treatment of hepatopathy as claimed in claim 1, it is characterized in that, described material composition is by weight: Pueraria lobota Bud root 6 parts, Semen Avenae fatuae 6 parts, large lip Radix seu Herba Pedicularis 5 parts, flat cattail leaf fan 2 parts, magnificent Ramulus et Folium Schoepfiae chinesis 6.5 parts, Ramulus et Folium Reinwardtiae Trigynae 4.5 parts, sinopimelodendron kwangsiense 4.5 parts, Cangshan Herba corydalis racemosae 7 parts, Cortex Araliae Elatae Radicis 2 parts, Herba saussureae nigrescentis 3 parts, thorn coriander 4.5 parts, Flos Bauhiniae Variegatae 5 parts, Herba Carpesii Cernui 5 parts, Adinandra millettii 6 parts, Caulis Marsdeniae tinctoriae 7.5 parts, Meehania urticaefolia 6.5 parts, Eriophyton wallichii Benth 3.5 parts, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain 5 parts.
3. a kind of pharmaceutical composition for the treatment of hepatopathy as claimed in claim 1 or 2, it is characterized in that, described material composition also comprises by weight: Radix Scutellariae 0.2 ~ 0.7 part, Rhizoma Coptidis 0.1 ~ 0.3 part, Cortex Phellodendri 0.3 ~ 0.7 part, Radix Gentianae 0.1 ~ 0.3 part, Cortex Fraxini 0.1 ~ 0.3 part, Radix Sophorae Flavescentis 0.3 ~ 0.7 part, Herba Taraxaci 0.1 ~ 0.3 part, Herba Menthae 0.1 ~ 0.3 part, Flos Chrysanthemi Indici 0.1 ~ 0.3 part.
4. a kind of pharmaceutical composition for the treatment of hepatopathy as claimed in claim 1 or 2, it is characterized in that, described material composition also comprises by weight: Radix Scutellariae 0.45 part, Rhizoma Coptidis 0.2 part, Cortex Phellodendri 0.5 part, Radix Gentianae 0.2 part, Cortex Fraxini 0.2 part, Radix Sophorae Flavescentis 0.5 part, Herba Taraxaci 0.2 part, Herba Menthae 0.2 part, Flos Chrysanthemi Indici 0.2 part.
5. a kind of pharmaceutical composition for the treatment of hepatopathy as described in Claims 1-4, is characterized in that, described material composition also comprises vitamin B 0.01 ~ 0.03 part, vitamin C 0.01 ~ 0.04 part, penicillin 0.0001 ~ 0.0003 part by weight.
6. a kind of preparation method for the treatment of the pharmaceutical composition of hepatopathy as described in claim 1 to 5 any one, is characterized in that, comprise the following steps:
(1) the Pueraria lobota Bud root of formula ratio is got, Semen Avenae fatuae, large lip Radix seu Herba Pedicularis, flat cattail leaf fan, China's Ramulus et Folium Schoepfiae chinesis, sinopimelodendron kwangsiense, Cangshan Herba corydalis racemosae, Cortex Araliae Elatae Radicis, Herba saussureae nigrescentis, Flos Bauhiniae Variegatae, Adinandra millettii, Caulis Marsdeniae tinctoriae, Meehania urticaefolia, Eriophyton wallichii Benth, Colquhounia coccinea Wall. var. mollis (Schlecht.) Prain, add the water of 8 ~ 10 times of medical material gross weight, soak 40 ~ 50 minutes in 40 ~ 45 DEG C of constant temperature, be placed in boiler and decoct extraction 1 ~ 3 time, each 1 ~ 3 hour, filter, obtain and merging filtrate, filtrate is evaporated to the extractum that relative density is 1.25 ~ 1.35 at 70 DEG C, adding ethanol to alcohol content is 80 ~ 90%v/v, leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, obtain active components A, for subsequent use,
(2) thorn coriander, the Herba Carpesii Cernui of formula ratio is got, the volume by volume concentration adding medical material gross weight 1 ~ 2 times is the alcohol dipping 30 ~ 40 hours of 60% ~ 70%, then with volume by volume concentration be 50 ~ 60% ethanol carry out percolation with the speed accounting for raw material total weight parts 0.5 ~ 0.7% per minute, collect the percolate being equivalent to medical material gross weight 3 ~ 10 times amount, reclaim ethanol, be evaporated to 1 ~ 1.6 times that is equivalent to medical material gross weight, filter, obtain active component B, for subsequent use;
(3) getting the Ramulus et Folium Reinwardtiae Trigynae of formula ratio, is the water soaking 10 ~ 15min of 85 ~ 95 DEG C by the temperature relative to its weight 20 ~ 30 times, filters, under filtrate reduced in volume to 70 DEG C environment, relative density is the extractum of 1.25 ~ 1.35, spray dried becomes extract powder, obtains active component C, for subsequent use;
(4) get the Radix Scutellariae of formula ratio, Rhizoma Coptidis, Cortex Phellodendri, Radix Gentianae, Cortex Fraxini, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Menthae, Flos Chrysanthemi Indici, dry, pulverize, add the soak by water 1 ~ 1.5h of medical material gross weight 6 ~ 10 times amount, filter; Filtering residue adds the soak by water 0.5 ~ 1.0h of medical material gross weight 5 ~ 6 times amount, filters.Merge twice filtrate, being evaporated to relative density under 70 DEG C of environment is the extractum of 1.25 ~ 1.35, dry, pulverize rear mistake 80 ~ 100 mesh sieve, obtains active component D, for subsequent use;
(5) 200 ~ 280 parts of waters for injection are got, above-mentioned active components A, active component B, active component C, active component D are dissolved in wherein, add vitamin B, vitamin C, penicillin, add the emulsifying agent, the antiseptic of 0.05 ~ 0.08%, the antioxidant of 0.03 ~ 0.06% that are equivalent to described water for injection weight 0.08 ~ 0.1% again, and be placed in ultrasonic disperse equipment and carry out supersound process 10 ~ 20s with the frequency of 40 ~ 60Hz, namely obtain the drug composition oral liquid for the treatment of hepatopathy.
7. a kind of preparation method for the treatment of the pharmaceutical composition of hepatopathy as claimed in claim 6, it is characterized in that, in described step (3), spray drying condition is: inlet temperature is 100 ~ 120 DEG C, leaving air temp is 80 ~ 90 DEG C, temperature of charge is 70 ~ 90 DEG C, atomizing pressure is 0.2 ~ 0.4 MPa, and spray velocity is 5 ~ 10ml/s.
8. a kind of preparation method for the treatment of the pharmaceutical composition of hepatopathy as claimed in claim 6, is characterized in that, described emulsifying agent be selected from sodium lauryl sulphate, sucrose monolaurate or fatty acid Pyrusussuriensis smooth in any one.
9. a kind of preparation method for the treatment of the pharmaceutical composition of hepatopathy as claimed in claim 6, is characterized in that, described antiseptic be selected from parabens, benzoate or sorbic acid any one.
10. a kind of preparation method for the treatment of the pharmaceutical composition of hepatopathy as claimed in claim 6, is characterized in that, described antioxidant be selected from BHT, sodium sulfite or sodium pyrosulfite any one.
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|---|---|---|---|---|
| CN101744954A (en) * | 2009-12-29 | 2010-06-23 | 谭友民 | Medicine for internally treating icteric hepatitis |
| CN101757509A (en) * | 2009-11-04 | 2010-06-30 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating icterohepatitis and preparation method thereof |
| CN101785804A (en) * | 2010-04-22 | 2010-07-28 | 通化金马药业集团股份有限公司 | Liver-cleansing yellow-removing medicament |
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| CN101757509A (en) * | 2009-11-04 | 2010-06-30 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating icterohepatitis and preparation method thereof |
| CN101744954A (en) * | 2009-12-29 | 2010-06-23 | 谭友民 | Medicine for internally treating icteric hepatitis |
| CN101785804A (en) * | 2010-04-22 | 2010-07-28 | 通化金马药业集团股份有限公司 | Liver-cleansing yellow-removing medicament |
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