CN105229160B - 工程化的抗-TGF-β抗体及抗原结合片段 - Google Patents

工程化的抗-TGF-β抗体及抗原结合片段 Download PDF

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CN105229160B
CN105229160B CN201480026283.5A CN201480026283A CN105229160B CN 105229160 B CN105229160 B CN 105229160B CN 201480026283 A CN201480026283 A CN 201480026283A CN 105229160 B CN105229160 B CN 105229160B
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antigen
antibody
binding fragment
tgf
human
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CN105229160A (zh
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R·魏
A·莫林
M·马蒂厄
C·潘
S·帕克
H·邱
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Genzyme Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00113—Growth factors
    • A61K39/001134—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201480026283.5A 2013-03-11 2014-03-11 工程化的抗-TGF-β抗体及抗原结合片段 Active CN105229160B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361776430P 2013-03-11 2013-03-11
US61/776,430 2013-03-11
PCT/US2014/023274 WO2014164709A2 (en) 2013-03-11 2014-03-11 Engineered anti-tgf-beta antibodies and antigen-binding fragments

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CN105229160A CN105229160A (zh) 2016-01-06
CN105229160B true CN105229160B (zh) 2020-06-23

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US11384350B2 (en) 2014-12-15 2022-07-12 The Regents Of The University Of California Cytotoxic molecules responsive to intracellular ligands for selective T cell mediated killing
TWI726870B (zh) 2015-03-04 2021-05-11 美商健臻公司 具有高親和性、結合性及專一性之結合轉形生長因子-β１的ｓｃＦｖ-Ｆｃ二聚體
TWI733661B (zh) 2015-03-04 2021-07-21 美商健臻公司 以高親合性、結合性及特異性結合轉化生長因子－β１的經修飾ＩｇＧ抗體
EP3331550B1 (en) 2015-08-04 2022-11-02 Acceleron Pharma Inc. Composition for treating myeloproliferative disorders
SMT202300027T1 (it) 2015-10-30 2023-05-12 Univ California Polipeptidi sensibili al fattore di crescita trasformante beta e le loro modalità d’uso
JP6920292B2 (ja) * 2015-10-30 2021-08-18 ジェネンテック， インコーポレイテッド ヒンジが修飾された抗体断片及び作製方法
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US11701384B2 (en) 2016-09-02 2023-07-18 The Regents Of The University Of California Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments
SI3628049T1 (sl) 2017-05-04 2023-10-30 Acceleron Pharma Inc. Fuzijske beljakovine receptorja TGF-beta tipa II in njihova uporaba
JP7544597B2 (ja) 2017-11-06 2024-09-03 ジェネンテック， インコーポレイテッド がんの診断及び療法
US12252531B2 (en) * 2018-07-11 2025-03-18 Scholar Rock, Inc. Methods of screening for high-affinity, isoform-selective TGFβ1 inhibitors
KR102376605B1 (ko) 2019-08-28 2022-03-21 추가이 세이야쿠 가부시키가이샤 종교차성 항잠재형 TGF-β1 항체 및 사용 방법
WO2021188749A1 (en) * 2020-03-19 2021-09-23 Genentech, Inc. Isoform-selective anti-tgf-beta antibodies and methods of use
US20220119513A1 (en) * 2020-06-08 2022-04-21 Zoetis Services Llc Anti-tgfb antibodies and therapeutic uses thereof
WO2022115611A1 (en) 2020-11-25 2022-06-02 Catamaran Bio, Inc. Cellular therapeutics engineered with signal modulators and methods of use thereof
EP4281474A4 (en) * 2021-01-21 2025-03-05 Biolojic Design Ltd. Dual binding antibodies, methods of producing dual binding antibodies, and uses thereof
CN112851819B (zh) * 2021-01-25 2023-08-11 华中科技大学同济医学院附属同济医院 结合小鼠PD-L1和TGF-β的双特异性抗体及其制备方法与应用
KR20230146032A (ko) 2021-02-15 2023-10-18 다케다 야쿠힌 고교 가부시키가이샤 Tgf-b 신호전달을 조절하기 위한 세포 치료 조성물 및 방법
CN113480645B (zh) * 2021-07-16 2022-11-11 甘肃中科博瑞生物工程有限公司 一种抗幽门螺旋杆菌重组抗体、制备方法及用途
WO2023080900A1 (en) 2021-11-05 2023-05-11 Genentech, Inc. Methods and compositions for classifying and treating kidney cancer
WO2024077095A1 (en) 2022-10-05 2024-04-11 Genentech, Inc. Methods and compositions for classifying and treating bladder cancer
WO2024077166A1 (en) 2022-10-05 2024-04-11 Genentech, Inc. Methods and compositions for classifying and treating lung cancer

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RU2015143156A (ru) 2017-04-13
KR102258457B1 (ko) 2021-05-31
AU2018203261B2 (en) 2020-03-26
WO2014164709A2 (en) 2014-10-09
MX2015012541A (es) 2016-02-10
HK1220731A1 (en) 2017-05-12
AR095240A1 (es) 2015-09-30
SI2971048T1 (sl) 2019-03-29
TR201901415T4 (tr) 2019-02-21
SG11201507279XA (en) 2015-10-29
JP2016512521A (ja) 2016-04-28
PL2971048T4 (pl) 2019-05-31
TWI613216B (zh) 2018-02-01
JP6495884B2 (ja) 2019-04-03
BR112015021595A2 (pt) 2017-10-10
US9783604B2 (en) 2017-10-10
IL241404A0 (en) 2015-11-30
US10730936B2 (en) 2020-08-04
MX365385B (es) 2019-05-31
DK2971048T3 (en) 2019-02-25
CA2904847A1 (en) 2014-10-09
US20170342144A1 (en) 2017-11-30
UY35384A (es) 2014-10-31
US20160017026A1 (en) 2016-01-21
EP2971048A2 (en) 2016-01-20
PT2971048T (pt) 2019-02-06
IL241404B (en) 2018-11-29
KR20150126397A (ko) 2015-11-11
AU2014249051A1 (en) 2015-10-01
TW201803592A (zh) 2018-02-01
CA2904847C (en) 2021-06-01
SG10201707021RA (en) 2017-10-30
AU2014249051B2 (en) 2018-02-15
WO2014164709A3 (en) 2014-12-24
EP3415633B1 (en) 2020-10-28
HUE042020T2 (hu) 2019-06-28
TW201522369A (zh) 2015-06-16
ES2713505T3 (es) 2019-05-22
RU2681502C2 (ru) 2019-03-06
AU2018203261A1 (en) 2018-05-31
PL2971048T3 (pl) 2019-05-31
LT2971048T (lt) 2019-02-25
ES2845215T3 (es) 2021-07-26
EP2971048A4 (en) 2016-11-02
EP3415633A1 (en) 2018-12-19
EP2971048B1 (en) 2018-10-31
HRP20190201T1 (hr) 2019-03-22
CN105229160A (zh) 2016-01-06
CY1121412T1 (el) 2020-05-29
TWI664979B (zh) 2019-07-11

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