CN105214157B - Apparatus for purifying blood and system - Google Patents
Apparatus for purifying blood and system Download PDFInfo
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- CN105214157B CN105214157B CN201510742232.9A CN201510742232A CN105214157B CN 105214157 B CN105214157 B CN 105214157B CN 201510742232 A CN201510742232 A CN 201510742232A CN 105214157 B CN105214157 B CN 105214157B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
- A61M1/1627—Dialyser of the inside perfusion type, i.e. blood flow inside hollow membrane fibres or tubes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3687—Chemical treatment
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- Urology & Nephrology (AREA)
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Abstract
The blood purification system that perfusion builds with the apparatus for purifying blood of adsorption function and with it is provided simultaneously with the invention provides a kind of.Wherein, apparatus for purifying blood includes unit with dialysis, connection unit and perfusion unit.Unit with dialysis include dialysis cartridge, and unit with dialysis import constitute apparatus for purifying blood blood inlet.Connection unit includes front port, rear port and the open-close on-off for controlling connection therebetween, the port of export port fixed seal connection of front port and unit with dialysis.Perfusion unit includes adsorption column, along the axial direction of the adsorption column, side through hole is provided with the middle part of the wall of adsorption column filter chamber side, the side through hole is provided with the inlet screen with intercommunicating pore away from the port of filter chamber and the rear port fixed seal connection of connection unit between the rear port and filter chamber of connection unit；The blood outlet of the export mixes apparatus for purifying blood on two axial ends of adsorption column.The apparatus for purifying blood can simultaneously improve the security and speed of blood purification treatment.
Description
Technical field
The present invention relates to medical instruments field, specifically, it is related to a kind of apparatus for purifying blood and is filled with the blood purification
Put the blood purification system of structure.
Background technology
Combined artificial kidney is a kind of haemodialysis（HD）Joint blood perfusion（HP）Apparatus for purifying blood, its abundant profit
With the advantage of blood perfusion and haemodialysis, have the advantages that good biocompatibility, adverse reaction be few, the blood purification time is short,
And can comprehensively remove the various toxin in the patients such as uremia.
The blood purification system of existing combined artificial kidney composition by outflow human body blood circuit arterial line, perfusion
The part of blood circuit venous line four composition of device, dialyzer and inflow human body.As shown in figure 1, blood circuit arterial line exists
Arterial end 01, blood pump 02, the artery kettle 03 and on artery kettle 03 connected by pipeline are sequentially provided with direction of flow of blood
Artery kettle side pipe 04；Blood circuit venous line is sequentially provided with the venous chambers connected by pipeline in direction of flow of blood
012 and vein end 014, and the venous chambers side pipe 013 on venous chambers 012；The blood mouth of the front end of perfusion device 07 is by connection
Port 06 is connected with the rear port of blood circuit arterial line, and in connectivity port 06 and the rear port of blood circuit arterial line
Between be provided with a safety clamp 05；The blood mouth of the front end of dialyzer 011 is by connectivity port 08 and connectivity port 010 and the rear end of perfusion device 07
Blood mouth connection, a safety clamp 09 is provided between connectivity port 08 and connectivity port 010；The blood mouth and blood of the rear end of dialyzer 011
The front port of liquid loop venous line is connected.The clinical treatment mode of the blood purification system is first haemodialysis（HD）Joint
Blood perfusion（HP）Treatment 2 hours, then haemodialysis 2 hours is individually carried out, arterial blood is extracted out by the work of blood pump 02 is passed through
Perfusion device 07 is crossed with dialyzer 011 or only by that, again by blood circuit venous line, will pass through after the purification of dialyzer 011
Detoxification, go after water, electrolysis mass transter in the defeated the Huis' body of blood that has purified, temporarily to play a part of to substitute human kidney function.
Perfusion device carries out absorption and reaches purification purpose by the adsorbent being filled in its adsorption column filter chamber to blood, is
The blood is set to quickly move through blood perfusion device to shorten the blood purification treatment time, with the increasing of CBF in perfusion device
Plus, the pressure that perfusion device internal blood applies is consequently increased, the maximum pressure that be can bear inside perfusion device is limited to, lead
The maximum blood flow that causing existing conventional blood perfusion device can allow is usually 200 ml/mins.But, with blood perfusion device
The maximum blood flow that the haemodialyser for using cooperatively can be allowed is being combined up to 300 ml/mins to 400 ml/mins
The CBF of whole combined artificial kidney is restricted to below 200 ml/mins in therapeutic process, causes blood purification treatment
Time lengthens, and is unfavorable for the carrying out of blood purification treatment, and increase blood purification treatment cost.
Additionally, be limited to the maximum blood flow that perfusion device is allowed, after therapeutic alliance is carried out, it has to the first company of pulling down
The pipeline being connected on perfusion device is then connected to dialyzer, carries out single dialysis treatment.During this, operating personnel need to stop
Machine, pulls down perfusion device and associated pipe, carries out blood back operation, it is necessary to disconnect blood circuit during perfusion device is dismantled, enters
The sequence of operations such as row dismounting, short circuit, this clinically increased the workload of operating personnel；And, if operating personnel exist
Misoperation is occurred in that during clinical manipulation, blood samples of patients loss is may result in, increase germ is invaded in blood samples of patients
Probability, increase patient's pain, or even the life of patient can be threatened.
The content of the invention
The main object of the present invention is to provide a kind of blood perfusion that is provided simultaneously with and is filled with the blood purification of haemodialysis function
Put, to improve the security and speed of blood purification treatment；
It is a further object of the present invention to provide the blood purification system that more than one state apparatus for purifying blood structure.
In order to realize above-mentioned main purpose, the apparatus for purifying blood that the present invention is provided include unit with dialysis, connection unit and
Perfusion unit.Unit with dialysis include dialysis cartridge, and unit with dialysis import constitute apparatus for purifying blood blood inlet.Connection is single
Open-close on-off of the unit including front port, rear port and for controlling connection therebetween, front port and the unit with dialysis port of export
Port fixed seal connection.Perfusion unit includes adsorption column, along the axial direction of the adsorption column, the middle part of adsorption column filter chamber side wall
Be provided with side through hole, the side through hole away from the port of filter chamber and the rear port fixed seal connection of connection unit, connection unit
Inlet screen is provided between rear port and filter chamber；One axial end of adsorption column is provided with first outlet, is set on another axial end
There is second outlet, the first outlet constitutes the blood outlet of apparatus for purifying blood with second outlet.
From above scheme, whole apparatus for purifying blood is used as an entirety, while possessing blood perfusion and blood
Dialysis function, can provide more preferable blood purification treatment for patient.In blood purification process, the connection side with transducer potector
Formula is simple, while operation is simplified, improves safety in utilization.By closing open-close on-off, by the inner chamber environment of adsorption column with
The inner chamber of dialysis cartridge is environmentally isolated, it is to avoid adsorbent fragment that may be present enters in dialysis cartridge in adsorption column, to dialysis membrane
Dialysis function is impacted, while different requirements that can be by dialysis membrane from adsorbent to storage environment humidity, accordingly realize
Dry and wet is preserved.Most of all, entering the filter chamber of adsorption column from the side wall middle part of adsorption column by the blood that dialysis cartridge is dialysed
It is interior, through the absorption of the adsorbent in filter chamber, the outlet outflow blood purification dress after completing to adsorb from the axial end of adsorption column two
Put, improve the maximum permissible value of the CBF of whole adsorption column, so as to improve the speed of therapeutic alliance, reduce blood purification treatment
Time, the pipeline dismounting for individually dialysing occurred again without first therapeutic alliance during haemodialysis and reconnection problem, carry
The security of blood purification treatment high.Further, since adsorbent is using same batch adsorbent and while fills out in whole adsorption column
Dress, effectively ensures that the homogeneity that blood purification effect is flowed out from two axial end upper outlets.
One specific scheme is closed for an axial end port of adsorption column by the first closing component, another axial end port
Closed by the second closing component；First outlet is located at the side away from side through hole on the end face of the first closing component；Second outlet
Away from the side of side through hole on the end face of the second closing component.Be conducive to excluding the blood in adsorption column, reduce blood residual
Allowance.
Another specific scheme is one towards the raised spherical crown shape in the direction away from connection unit rear port for inlet screen
Housing.The spherical crown shape housing includes containing portion and overflows mesh portion.Containing portion is the solid of the base section of the spherical crown shape housing
Structure, for containing blood.The open end of spherical crown shape housing to the partial shell between containing portion is made up of filtering net plate
Overflow mesh portion./ 6th of the depth of containing portion more than or equal to the internal diameter of spherical crown shape housing.Effectively anti-Hemostatic Oral Liquid is direct
On into the side wall relative with side through hole and directly from two axial end outlet outflows, blood depuration efficiency is improved, and can have
Blood flow and clean-up effect of the effect ground balance from the outlet outflow of two axial ends.
Another specific scheme is the dividing plate also included in filter chamber, and filter chamber is separated into the first mistake by the dividing plate
Filter chamber and the second filter chamber.Dividing plate is provided with several for the intercommunicating pore that connects the first filter chamber and the second filter chamber.Dividing plate
Middle face on thickness direction is mutually orthogonal with the central axis of adsorption column, and the central axis of side through hole is located in this on face.Every
The adsorbent that plate is effectively intercepted in filter chamber is united towards an axial end aggregation, effectively ensures blood pressure phase on two axial ends
When so as to improve blood purification validity and homogeneity.
Another specific scheme is that connection unit includes sleeve and for barrel bore to be separated into front port and rear end
The interlayer board of mouth, the centre of interlayer board plate face is provided with the via for turning on front port and rear port.Open-close on-off is located at
In via.Connection unit simple structure and effectively.
More specifically scheme is the port of the dialysis cartridge port of export by the external screw thread on its lateral surface and located at front end
The screw thread of internal thread coordinates and is fixedly connected with sleeve on intraoral side.Side through hole away from filter chamber port end face along away from mistake
The direction of filter chamber has convexed to form ring-type coupled wall, the ring-type coupled wall and side through hole coaxial arrangement, and ring-type coupled wall is by setting
Coordinate with the screw thread located at internal thread on rear port medial surface in the external screw thread on its lateral surface and be fixedly connected with sleeve.It is easy to
Assembling apparatus for purifying blood.
Another specific scheme is mutually orthogonal with the central axis of adsorption column for the central axis of dialysis cartridge.
Another specific scheme is that connection unit includes the first connecting tube and the second connecting tube.Open-close on-off includes valve body
And the valve element being placed in the valve body valve pocket, first through hole and the second through hole are formed with the side wall of valve pocket.The one of first connecting tube
Port and the external port fixed seal connection of first through hole, another port constitutes the front port of connection unit.Second connecting tube
The external port fixed seal connection of Single port and the second through hole, another port constitutes the rear port of connection unit.Valve element includes leading
Thread a pipe, the rotation of axle is rotated about by valve element, the conducting pipeline selectively connects the inner port and second of first through hole
The inner port of through hole.
One preferred scheme is 20 milliliters to 200 milliliters for the total capacity of adsorbent in adsorption column, is dialysed in dialysis cartridge
The gross area of film is 1.2 square metres to 2.0 square metres.
Another preferred scheme is that connection unit also includes entering line-locked locking for the open/close states to open-close on-off
Mechanism, and for indicating mechanism that the open/close states to open-close on-off are indicated.
In order to realize above-mentioned another object, the blood purification system that the present invention is provided includes blood transducer potector and is connected to this
Liquid purifier in transducer potector.Wherein, the blood purification dress that apparatus for purifying blood is provided by any of the above-described technical scheme
Put.
Brief description of the drawings
Fig. 1 is the transducer potector connection diagram of existing blood purification system；
Fig. 2 is the transducer potector connection diagram of blood purification system first embodiment of the present invention；
Fig. 3 is the structural representation of apparatus for purifying blood in blood purification system first embodiment of the present invention；
Fig. 4 is the structural decomposition diagram of apparatus for purifying blood in blood purification system first embodiment of the present invention；
Fig. 5 is A partial enlarged drawings in Fig. 4；
Fig. 6 is view of the open-close on-off in closing in blood purification system first embodiment of the present invention；
Fig. 7 is view of the open-close on-off in opening in blood purification system first embodiment of the present invention；
Fig. 8 is the structural representation of perfusion unit in blood purification system second embodiment of the present invention；
Fig. 9 is the structural representation of perfusion unit in blood purification system 3rd embodiment of the present invention；
Figure 10 is the structural representation of perfusion unit in blood purification system fourth embodiment of the present invention；
Figure 11 is the structural representation of open-close on-off locking mechanism in the embodiment of blood purification system of the present invention 5th；
Figure 12 is the structural representation of blood purification system sixth embodiment of the present invention；
Figure 13 is view of the open-close on-off in closing in the embodiment of blood purification system of the present invention 7th；
Figure 14 is view of the open-close on-off in opening in the embodiment of blood purification system of the present invention 7th.
With reference to embodiments and its accompanying drawing the invention will be further described.
Specific embodiment
The present invention is mainly improved to the structure of apparatus for purifying blood in blood purification system, relates generally to adsorption column
Attachment structure between dialysis cartridge, to improve blood purification treatment security and speed, the other parts of blood purification system
Structure is designed according to existing product.
Following embodiment mainly for blood purification system of the invention, because blood purification system of the present invention is employed
Apparatus for purifying blood of the invention, the saying to apparatus for purifying blood embodiment in the explanation of blood purification system embodiment
It is bright.
Blood purification system first embodiment
Blood purification system is by the blood circuit arterial line of outflow human body, apparatus for purifying blood and flows into the blood of human body
The part of loop venous line three constitutes.
Referring to Fig. 2, in direction of flow of blood, blood circuit arterial line is sequentially provided with the arterial end connected by pipeline
11st, blood pump 12 and artery kettle 13, and artery kettle side pipe 14 is provided with artery kettle 13；Blood circuit venous line is sequentially provided with logical
The venous chambers 16 and vein end 18 of pipeline connection are crossed, and venous chambers side pipe 17 is provided with venous chambers 16.
Apparatus for purifying blood 2 is made up of unit with dialysis 21, connection unit 22 and perfusion unit 23.Apparatus for purifying blood 2 leads to
The blood mouth crossed on unit with dialysis 21 is connected with the rear port of blood circuit arterial line, and by the blood mouth on perfusion unit 23
Front port with blood circuit venous line is connected.Safety clamp 15 is provided with blood circuit arterial line rear end.
Referring to Fig. 3 to Fig. 5, unit with dialysis 21 is used to realize the function of haemodialyser in existing blood purification system, its
Main element is dialysis cartridge 211, and the upper port end cap 212 of dialysis cartridge 211 is closed, the radial direction of the discoideus lid of end cap 212
Centre is provided with blood mouth 2120, and blood mouth 2120 is used to be connected with the rear port of blood circuit arterial line, the end of blood mouth 2120
Mouth is closed with block, and blood mouth 2120 constitutes the blood inlet of unit with dialysis 21, also constitutes the blood inlet of apparatus for purifying blood 2.
The lower port of dialysis cartridge 211 is closed by end cap 213, and the radial direction centre of the discoideus lid of end cap 213 is provided with port 2130, end
Mouth 2130 constitutes the outlet of unit with dialysis 21.Dialysis membrane is accommodated in the accommodating chamber of dialysis cartridge 211, dialysis membrane can be polyethers
The hemodialysis membrane of the materials such as sulfone, polysulfones, polypropylene.Bonding glue-line 2112 is provided with the both ends of the accommodating chamber of dialysis cartridge 211,
Between two bonding glue-lines 2112 and it is provided with dialyzate at the two side and exports 2110 and dialyzate import 2111.
The axial cross section of connection unit 22 is an I-shaped structure, and it has sleeve 220 and located at the inner chamber of sleeve 220 middle part
Annular interlayer board 221, sleeve pipe 220 is separated into upper and lower two ports, respectively front port 223 by annular interlayer board 221
It is for turning on front port 223 and rear port 224 positioned at the endoporus of the plate face centre of annular interlayer board 221 with rear port 224
Via 225, the open-close on-off 222 for controlling via 225 to open closure is installed in via 225.Via 225
It is internal diameter and the internal diameter identical ring chamber of perfusion unit 23 and the blood mouth of unit with dialysis 21.The medial surface of front port 223 is formed with use
In the internal thread being fixedly connected with port 2130.The medial surface of rear port 224 is formed with for the entrance point with perfusion unit 23
The external screw thread being fixedly connected.
Open-close on-off is a butterfly valve, is made up of valve rod 2221 and the flap 2222 being fixedly connected with valve rod 2221, flap
2222 is that a discoideus structure and its profile match with the medial surface to via 225, and valve rod 2221 is used to drive flap
2222 rotate around the central axis of valve rod 2221, and then turn off or on via 225.
Perfusion unit 23 is by adsorption column 231, the first closing component 232, the second closing component 233, and is placed in adsorption column 231
Adsorbent in filter chamber 2310 is constituted.Adsorbent can be resin sorbent, acticarbon, natural macromolecule adsorbent etc.
The combination of one or more in blood-purifying adsorbing agent.
Along the axial direction of adsorption column 231, the side wall middle part of filter chamber 2310 is formed with side through hole 235, and side through hole 235 is away from mistake
The port end face of filter chamber 2310 has convexed to form ring-type coupled wall 234, ring-type coupled wall 234 and the coaxial arrangement of side through hole 235, ring
The external screw thread matched with the internal thread on rear port 224 is formed with the lateral surface of shape coupled wall 234.Side through hole 235 away from
The port of rear port 224 is fixed with inlet screen 2311, and inlet screen 2311 is used to prevent adsorbent from being flowed from side through hole 225
Go out filter chamber 2310.
Sealing plain cushion mounting groove is equipped with upper two end faces of annular interlayer board 221, for installing sealing plain cushion.It is close
Internal diameter, the external diameter for sealing plain cushion are identical with annular interlayer board, when perfusion unit 23 and unit with dialysis 21 respectively with connection unit
After 22 are of coupled connections, the end face of the entrance blood mouth of the outlet blood mouth and perfusion unit 23 of unit with dialysis 21 is tight with sealing plain cushion respectively
Close fit, so as to realize unit with dialysis 21 and perfusion unit 23 respectively with the fixed seal connection of connection unit 22.
It is used to realize the function of blood perfusion device in existing blood purification system due to perfusion unit 23, in the present embodiment
In, closing component 211 is made up of filter screen, sealing plain cushion, end cap, locking nut and block.
Off-Radial centre and away from the one of side through hole 225 on the end face of the end cap lid in the first closing component 232
Side is provided with blood mouth 2320, and blood mouth 2320 is used to be connected with the front port of blood circuit venous line；In second closing component 233
End cap lid end face on the Off-Radial centre and side away from side through hole 225 is provided with blood mouth 2330, blood mouth 2330 is used
It is connected in the front port with blood circuit venous line.Blood mouth 2330 constitutes the second outlet of perfusion unit 23, blood mouth 2320
The first outlet of perfusion unit 23 is constituted, the two constitutes the blood outlet of apparatus for purifying blood 2 together.Controlled blood purification is completed
After treatment, the blood in pipeline and adsorption column 231 needs to be back to human body, because the blood mouth on the end cap at the two ends of adsorption column 231 sets
The bottom into blood mouthful one end is disposed away from, so when carrying out blood back, the blood in apparatus for purifying blood can be with total reflux the Huis
Body, it is to avoid blood cannot be drained and cause blood samples of patients to be lost in.
Referring to Fig. 6, flap 2222 is driven to rotate by reversing valve rod 2221, so that the surface of flap 2222 and annular
The plate face of interlayer board 221 is parallel, i.e., flap 2222 just blocks via 225, so as to realize front port 223 and rear port
224 separate, and make adsorption column 231 mutually isolated with the inner chamber of dialysis cartridge 211.
Referring to Fig. 7, it is rotated by 90 ° around the 2221 of valve rod axis by the driving flap 2222 of valve rod 2221, so that flap
2222 surface is mutually orthogonal with the plate face of annular interlayer board 221, i.e., flap 2222 no longer blocks via 225, so as to realize
Front port 223 is interconnected with rear port 224 by via 225.
The assembling process of apparatus for purifying blood 2 is as follows：
（1）Perfusion unit 23 is pre-installed with unit with dialysis 21 respectively；
（2）Close connection unit 22 on open-close on-off 222, will sealing plain cushion be mounted respectively to the annular of connection unit 22 every
On sealing plain washer mounting groove on laminate 221, make the ring-type coupled wall 234 of perfusion unit 23 along gravity direction upward, pass through
Screw thread coordinate ring-type coupled wall 234 is fixedly connected with the rear port 224 of connection unit 22, coupling in place after, sealing plain cushion and
The end face compression fit of ring-type coupled wall 234, so as to coordinate for the connection of the two provides sealing；Coordinated front port by screw thread
223 are fixedly connected with port 2130, after coupling in place, the end face compression fit of sealing plain cushion and port 2130, so as to be the two
Connection provide sealing coordinate；Complete the apparatus for purifying blood 2 after assembling, central axis and the adsorption column 231 of dialysis cartridge 211
Central axis it is mutually orthogonal.
（3）After the assembling for completing apparatus for purifying blood, whole apparatus for purifying blood is sterilized and packed.
Connection unit 22 is used to connect unit with dialysis 21 and perfusion unit 23, storage after production is completed and transports
Cheng Zhong, open-close on-off 222 is in closure state all the time, is on the one hand to prevent adsorbent fragment that may be present in adsorption column 231
222 are closed into being damaged to dialysis membrane in dialysis cartridge 211 by inlet screen 2311 and shear-blade；On the other hand it is adsorption column
231 may be different from the storage mode of dialysis cartridge 211, such as the inside of dialysis cartridge 211 preserves for dry state, and adsorption column 231 is interior
Portion preserves for hygrometric state, or the two is conversely, so as to isolating inside the two, effectively ensure the safety of apparatus for purifying blood 2
Property and validity.
Before blood purification treatment is carried out, pre- punching is first carried out to apparatus for purifying blood 2, pre- punching method is as follows：
Along gravity direction, unit with dialysis 21 is above, and perfusion unit 23 is located at lower section, connects after pipeline, rushes in advance
Liquid is injected in apparatus for purifying blood 2 from the blood mouth 2120 of unit with dialysis 21, by dialysis cartridge 211 and connection unit 22, Ran Houjin
Enter adsorption column 231, then first outlet by absorbing unit 23 flows out with second outlet, pre- fliud flushing is first passed through after dialysis membrane again to inhaling
Attached dose carries out pre- punching, prevents the adsorbent fragment in adsorption column 231 from entering in dialysis cartridge 211 with pre- fliud flushing, it is to avoid by perfusion
The pre- fliud flushing of unit 23 is polluted to dialysis membrane, to ensure the security and validity of apparatus for purifying blood 2.
When being treated, blood mouth 2120 of the blood from unit with dialysis 21 enters in apparatus for purifying blood 2, by dialysis
The Dialysis of dialysis membrane in post 211, subsequently into the filter chamber of adsorption column 231, through the suction of adsorbent in filter chamber 2310
Attached effect, the outlet from two axial ends is flowed back in transducer potector.Due to enter adsorption column 231 in blood be divided into two parts to
Two axial end upper outlets flow, and substantially correspond to simultaneously using two adsorption columns while carrying out suction-operated, increase is whole to be adsorbed
The maximum permissible value of the CBF of post 231, and then improve blood purification speed, and in use without first therapeutic alliance again
The operation such as detaching pipelines of independent dialysis treatment is carried out, operating time and the security risk that can be avoided therefore be brought is reduced.
In the present embodiment, the front port 223 of connection unit 22 and the internal diameter of rear port 224 elect 4 millimeters to 15 millimeters as, excellent
Elect 4 millimeters to 8 millimeters as.The total capacity of adsorbent is 20 milliliters to 200 milliliters, preferably 20 milliliters to 130 in adsorption column 231
Milliliter, the gross area of dialysis membrane is 1.2 square metres to 2.0 square metres in dialysis cartridge 211.
Blood purification system second embodiment
It is only pair real with blood purification system first below as the explanation to blood purification system second embodiment of the present invention
The difference for applying example is illustrated.
Referring to Fig. 8, inlet screen 3311 is to the raised spherical crown shape housing in the direction away from ring-type coupled wall 334, the ball
Coronal housing is half spherical shell structure, is solid construction on the hemispherical configuration base section, that is, be not provided with mesh, and mesh is located at
On the wall of spherical crown above section side, mesh is more than or equal to the hemisphere shell structure with the spacing at hemisphere shell structure medial surface minimum point
/ 6th of internal diameter, the i.e. depth of solid construction part make blood more than or equal to 1/6th of the internal diameter of hemisphere shell structure
Into after the bottom of inlet screen 3311, then adsorbed in filter chamber 33101 by there is mesh to overflow into, be effectively prevented from
The blood of high flow rate is directly entered the bottom of adsorption column 331 and the outlet from 331 liang of axial ends of adsorption column is flowed out, and makes blood and fills
Adsorbent in stream unit 23 is fully contacted, to improve adsorption effect.Solid construction part constitutes the splendid attire of inlet screen 3311
Portion, the spilling mesh portion of inlet screen 3311 is constituted located at the part of mesh, and it is surrounded by filtering net plate.
Blood purification system 3rd embodiment
It is only pair real with blood purification system second below as the explanation to blood purification system 3rd embodiment of the present invention
The difference for applying example is illustrated.
Referring to Fig. 9, the cross section of the inlet screen 4311 in adsorption column 431 is V-structure, mesh on its side wall and its
/ 3rd of the spacing of sharp corner more than or equal to V-structure depth.
Blood purification system fourth embodiment
It is only pair real with blood purification system second below as the explanation to blood purification system fourth embodiment of the present invention
The difference for applying example is illustrated.
Referring to Figure 10, dividing plate 5312 is provided with adsorption column 531, filter chamber 5310 is separated into two son filterings by dividing plate 5312
Chamber, respectively the first filter chamber 53101 and the second filter chamber 53102, middle face and adsorption column 531 on the thickness direction of dividing plate 5312
Central axis it is mutually orthogonal, and the central axis of side through hole 535 is located in this on face.Dividing plate 5312 is mainly used in making adsorption column
Adsorbent in 531 both ends is maintained in original space without flowing to the other end.The mesh of dividing plate 5312 is 300 microns
To 600 microns.It is preferred that being formed using polypropylene, makrolon or SBS material injections, be then again bonded the use of dividing plate 5312,
The modes such as welding are fixed on inside adsorption column 531, and it has the advantages that good permeability, hardness strength are larger, and can meet support
Separate the demand of adsorbent, and the internal gas of adsorption column 531 are difficult to the problem discharged when can avoid pre- punching.Dividing plate 5312 and entrance
Filter screen 5312 be in contact part using welding or bonding by the way of be fixedly connected.
Dividing plate 5312 is sieve-plate structure, so that the adsorbent capacity in the both ends of adsorption column 531 is in blood purification process
It is middle to keep suitable, it is to avoid adsorbent under the impact of liquid in thereto one end concentrate, it is ensured that the blood at the two ends of dialysis cartridge 531
Pressure quite, makes in the case where velocity of blood flow is higher, and the pressure inside perfusion unit 23 is still in preset range, it is to avoid fill
The problems such as there is blood coagulation or haemolysis inside stream unit 23, it is ensured that adsorbent safety and effectiveness over the course for the treatment of, it is ensured that control
Therapeutic effect.
The embodiment of blood purification system the 5th
It is only pair real with blood purification system first below as the explanation to the embodiment of blood purification system of the present invention 5th
The difference for applying example is illustrated.
Connection unit also has locking mechanism and indicating mechanism.
Referring to Figure 11, locking mechanism by elastic component, latch 62, shadoof 64 and coaxial with valve rod and be fixedly connected and coaxial cloth
The locking wheel 61 put is constituted, and elastic component is spring 63, and the first locking radially arranged is formed with the circumference of locking wheel 61
The lock slots 612 of groove 611 and second.The one end of spring 63 is connected on latch 62, and the other end is fixedly connected on connection unit；Shadoof
64 are fixedly connected on latch 62 near one end of spring 63.During switching open-close on-off, shadoof 64 need to be first pulled, in making locking wheel 61
The first lock slots 611（Such as closed mode）Separated with latch 62, then rotary valve rod, it is extensive in spring 63 after decontroling shadoof 64
In the presence of multiple power, latch 62 inserts the second lock slots 612 of locking wheel 61（Such as open mode）It is interior so that open-close on-off from
First state such as open mode switches to the second state as closed, and completes the locking to valve rod by locking mechanism.When need from
When second state switches to first state, same first pulling shadoof 64, then opposite direction rotary valve rod again, realizes open-close on-off
Open/close states switching.Locking mechanism is effectively prevented from transport and storing process under non-artificial external force effect, and keying is opened
Pass is opened, or is closed in blood purification process, so as to produce unnecessary influence.
Indicating mechanism is constituted in the keying indicating graduation on sleeve lateral surface and portraying by portraying in the instruction on valve rod.
Blood purification system sixth embodiment
It is only pair real with blood purification system first below as the explanation to blood purification system sixth embodiment of the present invention
The difference for applying example is illustrated.
Referring to Figure 12, the connection unit 8 between unit with dialysis 7 and perfusion unit 9 is connected to by the first connecting tube 81, valve
82nd, the connecting tube 84 of rotary shaft 83 and second is constituted, and the upper port of the first connecting tube 81 is constituted for the port of export with unit with dialysis
The front port of port fixed seal connection, the lower port of the second connecting tube 84 is constituted fixes close with the entrance point port of perfusion unit
Seal the rear port of connection.
Valve 82 is made up of the valve element 822 and valve body 821 of round pie, and valve body 821 is formed with the valve matched with valve element 822
Chamber, the outer peripheral face of valve element 822 seals against each other cooperation with the inner peripheral surface of valve pocket.
The end face of the upper port 841 of the connecting tube 84 of lower port 811 and second of the first connecting tube 81 is arcwall face structure,
And two ports connect by located at the first through hole and the second through hole that accommodate in groove sidewall with holding tank, are set on valve element 822
There is guide pipeline 8221, it is port 82211 and port 82212 to turn on the two-port of pipeline 8221.
Valve 82 is fixed on by the side of the first connecting tube 81 and the second connecting tube 84 by rotary shaft 83.
As shown in figure 12, conduction pipe is led 8221 two ends ports and is not docked with lower port 811 and upper port 841, is now opened
Make and break is closed and is closed.Valve element 822 is set to rotate 180 degree around rotary shaft 83, so that port 82211 and upper port 841 pairs
Connect, port 82212 is docked with lower port 811, so as to realize the unlatching of open-close on-off.
The embodiment of blood purification system the 7th
It is only pair real with blood purification system first below as the explanation to the embodiment of blood purification system of the present invention 7th
The difference for applying example is illustrated.
Referring to Figure 13 and Figure 14, open-close on-off is a stop valve, and the stop valve is by flap 9251, nut casing 9252, valve
Bar 9253 and handle 9254 are constituted, and handle 9254 is fixedly connected with one end of valve rod 9253, the other end end of valve rod 9253 outside
Face is formed with the external screw thread matched with the internal thread of nut casing 9252, and flap 9251 is with nut casing 9253 away from valve rod 9253
One end be fixedly connected.
By rotary handle 9254, by the effect of helicitic texture, flap 9251 is driven along the axial movement of valve rod 9253,
So as to block the via 924 on annular interlayer board or away from via 924, realize to the unlatching of via 924 with
The control of closing.
Central scope of the invention is changed with the attachment structure of adsorption column by dialysis cartridge in apparatus for purifying blood
Enter, the outlet and the adsorption column side supermedial side through hole of wall that make dialysis cartridge carry out the connection of control able to turn on or off, the blood after absorption
Outlet outflow from the axial end of adsorption column two, to improve the security and speed of blood purification treatment.According to present inventive concept,
The structure of inlet screen and the structure of connection unit also have various obvious changes.
Claims (11)
1. apparatus for purifying blood, including unit with dialysis, perfusion unit and connection unit：
The unit with dialysis includes dialysis cartridge；
The perfusion unit includes adsorption column；
It is characterized in that：
The import of the unit with dialysis constitutes the blood inlet of the apparatus for purifying blood；
The connection unit includes front port, rear port and for controlling the connection between the front port and the rear port
Open-close on-off, the port fixed seal connection of the front port and the port of export of the unit with dialysis；
Along the axial direction of the adsorption column, side through hole is provided with the middle part of the side wall of the filter chamber of the adsorption column, the side through hole is remote
From the port of the filter chamber and the rear port fixed seal connection, entrance is provided between the rear port and the filter chamber
Filter screen；
One axial end of the adsorption column is provided with first outlet, and another axial end is provided with second outlet, the first outlet
The blood for constituting the apparatus for purifying blood with the second outlet is exported.
2. apparatus for purifying blood according to claim 1, it is characterised in that：
The port of one axial end of the adsorption column is closed by the first closing component, and the port of another axial end is by the second sealing group
Part is closed；
The first outlet is located at the side away from the side through hole on the end face of first closing component；The second outlet
Away from the side of the side through hole on the end face of second closing component.
3. apparatus for purifying blood according to claim 1, it is characterised in that：
The inlet screen is towards the raised spherical crown shape housing in the direction away from the rear port；
The spherical crown shape housing includes containing portion and overflows mesh portion；
The containing portion is the solid construction of the base section of the spherical crown shape housing, for containing blood；
The open end of the spherical crown shape housing to the partial shell between the containing portion be made up of filtering net plate it is described overflow
Go out mesh portion；
/ 6th of the depth of the containing portion more than or equal to the internal diameter of the spherical crown shape housing.
4. apparatus for purifying blood according to claim 1, it is characterised in that：
Also include the dividing plate in the filter chamber, the filter chamber is separated into the first filter chamber and the second mistake by the dividing plate
Filter chamber；
The dividing plate is provided with several for connecting first filter chamber with the intercommunicating pore of second filter chamber；
Middle face on the thickness direction of the dividing plate is mutually orthogonal with the central axis of the adsorption column, and in the side through hole
Heart axis is located on the middle face.
5. apparatus for purifying blood according to claim 1, it is characterised in that：
The connection unit includes sleeve and for the inner chamber of the sleeve to be separated into the front port with the rear port
Interlayer board, the centre of the plate face of the interlayer board is provided with the via for turning on the front port and the rear port；
The open-close on-off is in the via.
6. apparatus for purifying blood according to claim 5, it is characterised in that：
The port of the port of export of the dialysis cartridge is by the external screw thread on its lateral surface and the inner side located at the front port
The screw thread of the internal thread on face coordinates and is fixedly connected with the sleeve；
The side through hole has convexed to form ring-type away from the end face of the port of the filter chamber along the direction away from the filter chamber
Coupled wall, the ring-type coupled wall and the side through hole coaxial arrangement, the ring-type coupled wall is by its lateral surface
External screw thread coordinates with the screw thread of the internal thread on the medial surface of the rear port and is fixedly connected with the sleeve.
7. apparatus for purifying blood according to claim 1, it is characterised in that：
The central axis of the dialysis cartridge is mutually orthogonal with the central axis of the adsorption column.
8. apparatus for purifying blood according to claim 1, it is characterised in that：
The connection unit includes the first connecting tube and the second connecting tube；
The open-close on-off includes valve body and the valve element that is placed in the valve pocket of the valve body, and the is formed with the side wall of the valve pocket
One through hole and the second through hole；
The Single port of first connecting tube and the external port fixed seal connection of the first through hole, before another port is described
Port；
The external port fixed seal connection of the Single port of second connecting tube and second through hole, another port is for after described
Port；
The valve element includes conducting pipeline, and the rotation of axle is rotated about by the valve element, and the conducting pipeline selectively connects
Lead to the inner port of the first through hole and the inner port of second through hole.
9. the apparatus for purifying blood according to any one of claim 1 to 8, it is characterised in that：
The total capacity of adsorbent is 20 milliliters to 200 milliliters in the adsorption column, and the gross area of dialysis membrane is in the dialysis cartridge
1.2 square metres to 2.0 square metres.
10. the apparatus for purifying blood according to any one of claim 1 to 8, it is characterised in that：
The connection unit also includes entering line-locked locking mechanism for the open/close states to the open-close on-off, and for right
The indicating mechanism that the open/close states of the open-close on-off are indicated.
11. blood purification systems, including transducer potector and the apparatus for purifying blood that is connected in the transducer potector；
It is characterized in that：
The apparatus for purifying blood is apparatus for purifying blood described in any one of claim 1 to 10.
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| CN201510742232.9A CN105214157B (en) | 2015-11-02 | 2015-11-02 | Apparatus for purifying blood and system |
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Address after: 519080 Zhuhai hi tech Zone No. six road, Guangdong Province, 98 Patentee after: Jianfan Biotechnology Group Co., Ltd. Address before: 519080 Zhuhai hi tech Zone No. six road, Guangdong Province, 98 Patentee before: Jafron Biomedical Co., Ltd. |