CN202078582U - Combined in-vitro artificial liver support treatment system - Google Patents
Combined in-vitro artificial liver support treatment system Download PDFInfo
- Publication number
- CN202078582U CN202078582U CN 201120026021 CN201120026021U CN202078582U CN 202078582 U CN202078582 U CN 202078582U CN 201120026021 CN201120026021 CN 201120026021 CN 201120026021 U CN201120026021 U CN 201120026021U CN 202078582 U CN202078582 U CN 202078582U
- Authority
- CN
- China
- Prior art keywords
- albumin
- dialyser
- outlet
- blood
- pipeline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- External Artificial Organs (AREA)
Abstract
A combined in-vitro artificial liver support treatment system comprises an input end, an output end, an in-vitro blood circulating pipeline and an albumin liquid circulating pipeline, wherein the input end is connected with an inlet of a blood plasma separator, and an outlet of the blood plasma separator is connected on the output end so as to form the in-vitro blood circulating pipeline; the blood plasma outlet of the blood plasma separator is connected to a blood plasma cavity inlet of a first dialyser by a bilirubin absorbing column, and a blood plasma cavity outlet of the first dialyser is connected on the outlet of the blood plasma separator in parallel so as to form the blood plasma circulating pipeline; and an albumin cavity outlet of the first dialyser is connected with an albumin cavity inlet of a second dialyser, and an albumin cavity outlet of the second dialyser is connected with the albumin cavity inlet of the first dialyser so as to form the albumin liquid circulating pipeline. In the utility model, the existing albumin dialyzing technology is combined with the bilirubin absorbing column optimally, the overall treatment efficiency is superior than that of the albumin dialysis, and the survival rate is similar to that of the blood plasma exchanging rate reported in the nation, and the capability of cleaning bilirubin is obviously superior than that of the albumin dialysis.
Description
Technical field
This utility model relates to a kind of armarium, and particularly a kind of temporary transient and alternative liver function of part is removed toxin and toxic metabolite, thus the external artificial liver support system of treatment hepatic insufficiency, liver failure or relevant disease.
Background technology
Hepatitis gravis/liver failure is the serious liver injury that multiple factor causes, cause that it is synthetic, function generation serious hindrance such as detoxifcation, drainage and biotransformation or lose compensatory, appearance serves as one group of clinical syndrome of main performance with disturbances of blood coagulation and jaundice, hepatic encephalopathy, ascites etc., and its mortality rate is up to 60～80%.There are internal medicine Comprehensive Treatment, external artificial rami hepatici to hold treatment and liver transplantation for the present main method of the treatment of this disease.Wherein, external artificial rami hepatici is held and is meant by external machinery, physical chemistry or biological device, remove various harmful substances, replenish essential material, environment in regulating, based on liver powerful regeneration capacity is arranged, temporarily substitute the Therapeutic Method of depleted liver partial function, can create conditions or wait for that chance carries out liver transplantation for liver cell regeneration and liver function recovery.
Artificial liver support system is divided into abiotic type, biotype and combined three kinds.Abiotic type artificial liver is in wide clinical application and be proved to be and truly have certain curative effect.Abiotic type artificial liver method comprises plasmapheresis (plasma exchange, PE), hemoperfusion (hemoperfusion, HP), hemofiltration (hemofiltration, HF), hemodialysis (hemodialysis, HD), albumin dialysis (comprising molecular adsorbent recirculation system (MARS) and albumin absorption recirculating system (PARS)) etc.And biotype and the combination Biotype artificial rami hepatici system of holding still are in conceptual phase at present.
In abiotic type artificial liver therapy system, molecular adsorbent recirculation system (MARS) is the representative of albumin dialysis technology, can remove water solublity, fat-soluble toxin and regulate water, electrolyte and acid-base balance, improves hepatitis gravis patient overall survival rate.But MARS treats expensive, and the technical equipment dependence on import can't solve the predicament that present China artificial liver is treated.In order to reduce the treatment cost, China has developed the albumin absorption recirculating system (PARS) similar to the MARS principle, and the simple albumin dialysis technology of back appearance, its medical expense decreases than MARS, but important toxicant abilities such as above-mentioned three kinds of albumin dialysis technology removing bilirubin are still very limited, the bilirubin rate of descent is about 20-35%, is starkly lower than plasmapheresis (50-60%).
Existing albumin absorption recirculating system (PARS), concrete structure can be announced on August 30th, 2006 disclosed referring to Chinese patent, the applying date is on June 22nd, 2005, and the patent No. is 200520012663.1, and name is called the utility model patent of " a kind of external artificial liver support system ".Disclosing albumin absorption recirculating system in this patent scheme is to be made of extracorporeal circulation of blood pipeline, albumin circulation line and dialysis solution circulation line three road.
Summary of the invention
This utility model purpose has provided a kind of novel artificial rami hepatici that albumin dialysis and plasma perfusion is combined and has held therapy system, to solve in the removing patient body that existing albumin dialysis technology exists the insufficient problem of important toxicant effect such as bilirubin.
For achieving the above object, the technical solution adopted in the utility model is: a kind of combined external artificial rami hepatici is held therapy system, comprise input, outfan, extracorporeal circulation of blood pipeline and albumin liquid circulation line, increasing between described extracorporeal circulation of blood pipeline and albumin liquid circulation line has the plasma circulation pipeline; The inlet of described input termination one plasma separator, the outlet of this plasma separator are connected to and constitute described extracorporeal circulation of blood pipeline on the described outfan, and string has blood pump in this extracorporeal circulation of blood pipeline; The blood plasma outlet of described plasma separator is connected to the blood plasma chamber inlet of first dialyser through a bilirubin adsorption column, the blood plasma chamber of this first dialyser exports and constitutes described plasma circulation pipeline in the outlet that is connected to plasma separator, and this plasma circulation pipeline string has blood plasma pump; The albumin chamber outlet of described first dialyser connects the albumin chamber inlet of second dialyser, the albumin chamber inlet that the albumin chamber outlet of second dialyser is connected to first dialyser constitutes described albumin liquid circulation line, and string has the albumin liquid pump in this albumin liquid circulation line.
Related content in the technique scheme is explained as follows:
1, in the such scheme, also comprises the displacement liquid pipeline, comprise the displacement sap cavity of ultrafiltrate vessel, displacement liquid container and second dialyser in this displacement liquid pipeline; The outlet of the displacement sap cavity of described second dialyser connects the ultrafiltrate vessel; And described displacement liquid outlet of container is connected in the albumin liquid circulation line, constitutes to filter mechanism.Also can: again the displacement liquid outlet of container is also connected the inlet of the displacement sap cavity of second dialyser, is constituted dialysis filtration mechanism, further improve the ability of removing toxin with this.
2, in the such scheme, also be serially connected with active carbon adsorption column, anion exchange resin adsorption column and the albuminous device of similar adsorbable regeneration in the described albumin liquid circulation line.
3, in the such scheme, described " first dialyser " must adopt the high flux dialyser, and " second dialyser " also adopts the high flux dialyser.Described dialyser is a prior art, and it generally all has two individual cavity, separates mutually with semipermeable membrane between two cavitys.Logical blood plasma in the cavity of first dialyser is named and is the blood plasma chamber, and logical albumin liquid in another cavity is named and is the albumin chamber.And logical albumin liquid in the cavity of second dialyser is named and is the albumin chamber, logical displacement liquid in another cavity, and naming is the displacement sap cavity.
Design principle of the present utility model and the effect of bringing are: this utility model will have albumin dialysis technology and the optimum organization of bilirubin adsorption column now, its treatment total effective rate is better than the albumin dialysis, similar to the plasmapheresis survival rate of domestic report, and remove bilirubinic ability and dialyse apparently higher than albumin.Thereby therapeutic effect of the present utility model is better than the albumin dialysis.And, along with China's artificial liver material and its curative effect of development of technology and safety will be improved constantly.To be specially adapted to treat the serious disorderly hepatitis gravis patient of environment in hyperbilirubinemia, high endotoxemia and water, electrolyte, the acid-base balance etc. clinically, and be worth further promoting.
Description of drawings
Accompanying drawing 1 is this utility model embodiment one circulation line sketch map;
Accompanying drawing 2 is this utility model embodiment two circulation line sketch maps.
In the above accompanying drawing: 1, input; 2, outfan; 3, blood pump; 4, first dialyser; 5, relief valve; 6, second dialyser; 7, albumin liquid pump; 8, displacement liquid container; 9, ultrafiltrate vessel; 10, the outlet of second dialyser displacement sap cavity; 11, the inlet of second dialyser displacement sap cavity; 12, first dialyser blood chamber inlet; 13, first dialyser blood chamber outlet; 14, first dialyser albumin chamber inlet; 15, first dialyser albumin chamber outlet; 16, second dialyser albumin chamber inlet; 17, second dialyser albumin chamber outlet; 18, active carbon adsorption column; 19, anion exchange resin adsorption column; 20, volume governor; 21, transducer potector bubble trap; 22, vascular funnel; 23, blood leakage monitor; 24, albumin liquid pipeline bubble trap; 25, liquid feeding pump; 26, positive displacement pump; 27, plasma separator; 28, blood plasma pump; 29, bilirubin adsorption column; 30, plasma separator inlet; 31, plasma separator outlet; 32, plasma separator blood plasma outlet.
The specific embodiment
Below in conjunction with drawings and Examples this utility model is further described:
Embodiment one: shown in accompanying drawing 1, a kind of novel external artificial rami hepatici is held therapy system, is made of extracorporeal circulation of blood pipeline, plasma circulation pipeline, albumin liquid circulation line and displacement liquid pipeline four parts.
Shown in accompanying drawing 1, described input 1 connects the inlet 30 of a plasma separator 27, and the outlet 31 of this plasma separator 27 is connected to the outer blood circulation pipeline of constituting body on the described outfan 2, and string has blood pump 3 in this extracorporeal circulation of blood pipeline.The blood plasma outlet 32 of described plasma separator 27 is connected to the blood plasma chamber inlet 12 of first dialyser 4 through a bilirubin adsorption column 29, the blood plasma chamber of this first dialyser 4 outlet 13 is connected in the outlet 31 of plasma separator 27 and constitutes described plasma circulation pipeline, and this plasma circulation pipeline string has blood plasma pump 28.The albumin chamber outlet 15 of described first dialyser 4 connects the albumin chamber inlet 16 of second dialyser 6, the albumin chamber inlet 14 that the albumin chamber outlet 17 of second dialyser 6 is connected to first dialyser 4 constitutes described albumin liquid circulation line, and string has albumin liquid pump 7 in this albumin liquid circulation line.The displacement sap cavity that comprises ultrafiltrate vessel 9, displacement liquid container 8 and second dialyser 6 in the described displacement liquid pipeline; The outlet 10 of the displacement sap cavity of described second dialyser 6 connects ultrafiltrate vessel 9 through positive displacement pump 26; And the outlet of described displacement liquid container 8 is connected in the albumin liquid circulation line, and is concrete, described displacement liquid container 8 16 places that enter the mouth through the albumin chamber that liquid feeding pump 25 is connected in second dialyser 6.
Also be serially connected with active carbon adsorption column 18, anion exchange resin adsorption column 19, volume governor 20, blood leakage monitor 23 and albumin liquid pipeline bubble trap 24 in the described albumin liquid circulation line.
Also be serially connected with transducer potector bubble trap 21, vascular funnel 22 and relief valve 5 in the described extracorporeal circulation of blood pipeline.
In the present embodiment, can set up heater on the described displacement liquid container 8, by heater displacement liquid be heated, make displacement liquid reach the suitable temperature that human body is accepted, when making treatment, it is more comfortable that the patient feels.
First dialyser of using in the present embodiment 4 adopts the hundred special HF1200 of company dialysers, and second dialyser 6 adopts Fresenius AV600 dialyser.
During use, patients'blood is at first by plasma separator 27, and isolated blood plasma is handled by the bilirubin adsorption column 29 and first dialyser 4 more successively, and the blood plasma of final purification is in hemocyte feeds back the patient body.
Embodiment two: shown in accompanying drawing 2, a kind of novel external artificial rami hepatici is held therapy system, is made of extracorporeal circulation of blood pipeline, plasma circulation pipeline, albumin liquid circulation line and displacement liquid pipeline four parts.
The difference of it and embodiment one is: described displacement liquid container 8 is not 16 places that enter the mouth, the albumin chamber that is connected in second dialyser through liquid feeding pump 25, but displacement liquid container 8 is divided into two-way through liquid feeding pump 25, one the road is connected on the displacement sap cavity inlet 11 of second dialyser 6, another road is connected in the albumin circulation line in second dialyser, the 6 albumin chambeies outlet 17, make flow through the from bottom to top displacement sap cavity of second dialyser 6 of one road displacement liquid (as shown in the figure) with this, another road displacement liquid flows in the albumin circulation line and circulates with albumin, finish dialysis simultaneously and filter formation dialysis filtration system.
The foregoing description only is explanation technical conceive of the present utility model and characteristics, and its purpose is to allow the personage who is familiar with this technology can understand content of the present utility model and enforcement according to this, can not limit protection domain of the present utility model with this.All equivalences of being done according to this utility model spirit change or modify, and all should be encompassed within the protection domain of the present utility model.
Claims (4)
1. a combined external artificial rami hepatici is held therapy system, comprise input (1), outfan (2), extracorporeal circulation of blood pipeline and albumin liquid circulation line, it is characterized in that: increasing between described extracorporeal circulation of blood pipeline and albumin liquid circulation line has the plasma circulation pipeline; Described input (1) connects the inlet (30) of a plasma separator (27), the outlet (31) of this plasma separator (27) is connected to described outfan (2) and goes up the described extracorporeal circulation of blood pipeline of formation, and string has blood pump (3) in this extracorporeal circulation of blood pipeline; The blood plasma outlet (32) of described plasma separator (27) is connected to the blood plasma chamber inlet (12) of first dialyser (4) through a bilirubin adsorption column (29), the blood plasma chamber outlet (13) of this first dialyser (4) is connected to the outlet (31) of plasma separator (27) and goes up the described plasma circulation pipeline of formation, and this plasma circulation pipeline string has blood plasma pump (28); The albumin chamber outlet (15) of described first dialyser (4) connects the albumin chamber inlet (16) of second dialyser (6), the albumin chamber inlet (14) that the albumin chamber outlet (17) of second dialyser (6) is connected to first dialyser (4) constitutes described albumin liquid circulation line, and string has albumin liquid pump (7) in this albumin liquid circulation line.
2. a kind of combined external artificial rami hepatici according to claim 1 is held therapy system, it is characterized in that: also comprise the displacement liquid pipeline, comprise the displacement sap cavity of ultrafiltrate vessel (9), displacement liquid container (8) and second dialyser (6) in this displacement liquid pipeline; The outlet (10) of the displacement sap cavity of described second dialyser (6) connects ultrafiltrate vessel (9); And the outlet of described displacement liquid container (8) is connected in the albumin liquid circulation line.
3. a kind of combined external artificial rami hepatici according to claim 1 is held therapy system, and it is characterized in that: the inlet (11) of the displacement sap cavity of second dialyser (6) is also connected in the outlet of described displacement liquid container (8), constitutes dialysis filtration mechanism with this.
4. a kind of combined external artificial rami hepatici according to claim 1 is held therapy system, it is characterized in that: also be serially connected with active carbon adsorption column (18) and anion exchange resin adsorption column (19) in the described albumin liquid circulation line.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120026021 CN202078582U (en) | 2011-01-26 | 2011-01-26 | Combined in-vitro artificial liver support treatment system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120026021 CN202078582U (en) | 2011-01-26 | 2011-01-26 | Combined in-vitro artificial liver support treatment system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202078582U true CN202078582U (en) | 2011-12-21 |
Family
ID=45339242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201120026021 Expired - Fee Related CN202078582U (en) | 2011-01-26 | 2011-01-26 | Combined in-vitro artificial liver support treatment system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202078582U (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263704A (en) * | 2013-05-09 | 2013-08-28 | 浙江大学 | Plasma exchanging adsorption filtration purification system provided with plasma storage bag and application method of purification system |
| CN103263705A (en) * | 2013-05-09 | 2013-08-28 | 浙江大学 | Plasma exchange absorption filter purifying system with square plasma storage tank |
| CN103520787A (en) * | 2012-07-06 | 2014-01-22 | 中国科学院大连化学物理研究所 | Mixed type artificial liver based on loading microcapsule reciprocating type bioreactor |
| CN104524651A (en) * | 2014-12-17 | 2015-04-22 | 珠海健帆生物科技股份有限公司 | Bilirubin adsorption system and regeneration method thereof |
| CN105056325A (en) * | 2015-08-07 | 2015-11-18 | 王晓芝 | Novel plasma filtering and adsorbing system |
-
2011
- 2011-01-26 CN CN 201120026021 patent/CN202078582U/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520787A (en) * | 2012-07-06 | 2014-01-22 | 中国科学院大连化学物理研究所 | Mixed type artificial liver based on loading microcapsule reciprocating type bioreactor |
| CN103520787B (en) * | 2012-07-06 | 2016-09-14 | 中国科学院大连化学物理研究所 | A kind of based on the hybrid artificial liver carrying microcapsule reciprocating bioreactor |
| CN103263704A (en) * | 2013-05-09 | 2013-08-28 | 浙江大学 | Plasma exchanging adsorption filtration purification system provided with plasma storage bag and application method of purification system |
| CN103263705A (en) * | 2013-05-09 | 2013-08-28 | 浙江大学 | Plasma exchange absorption filter purifying system with square plasma storage tank |
| CN103263704B (en) * | 2013-05-09 | 2015-10-28 | 浙江大学 | Be equipped with the plasmapheresis absorption filtration cleaning system of slurry storing bag |
| CN104524651A (en) * | 2014-12-17 | 2015-04-22 | 珠海健帆生物科技股份有限公司 | Bilirubin adsorption system and regeneration method thereof |
| CN105056325A (en) * | 2015-08-07 | 2015-11-18 | 王晓芝 | Novel plasma filtering and adsorbing system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105120913B (en) | Sodium and buffer solution source capsule for the controlled compatible stream of modularization | |
| Ronco et al. | The Vicenza wearable artificial kidney for peritoneal dialysis (ViWAK PD) | |
| CN105025951B (en) | For the system and method for multi-functional volume fluid control | |
| CN1071585C (en) | Hemofiltration and Plasmafiltration device and methods | |
| JP4177898B2 (en) | Continuous flow-through peritoneal dialysis (CFPD) with controlled intra-abdominal pressure | |
| CN103263704B (en) | Be equipped with the plasmapheresis absorption filtration cleaning system of slurry storing bag | |
| CN201033178Y (en) | Novel external artificial liver supporting and treating system | |
| CN202078582U (en) | Combined in-vitro artificial liver support treatment system | |
| CN105007958A (en) | Degassing module for a controlled compliant flow path | |
| CN102389594B (en) | Portable blood purifying system | |
| CN201026321Y (en) | Artificial liver nephros support system | |
| CN100493633C (en) | Artificial system for supporting liver and kidney | |
| CN203196047U (en) | Combined type liver extracorporal artificial purification supportive treatment system | |
| CN203507201U (en) | Separating type hemodialysis absorber | |
| CN106344985A (en) | Multifunctional regenerative blood purification system | |
| CN203619966U (en) | Blood ascites purifying device for hemodiafiltration joint ascites ultrafiltration and reinfusion | |
| CN202207346U (en) | Portable blood purifying system | |
| CN203354984U (en) | Plasma exchange adsorption filtration purification system for preparing square plasma storage pond | |
| CN203244631U (en) | Plasma storage bag for plasma exchange, absorbing and filtering treatment | |
| CN104524653A (en) | Artificial liver and blood purification system | |
| CN203280813U (en) | Plasma exchange absorption filtering purifying system provided with plasma storage bag in matched mode | |
| CN103263706A (en) | Plasma storage bag special for plasma exchange, absorption, and filtration treatment | |
| CN203989183U (en) | The apparatus for purifying blood of integrated strip hemoperfusion and hemodialysis structure | |
| CN203417361U (en) | Square plasma storage pool special for plasma exchange adsorption filtration treatment | |
| CN203139198U (en) | Simple blood purifier |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111221 Termination date: 20130126 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |