CN103263705A - Plasma exchange absorption filter purifying system with square plasma storage tank - Google Patents

Plasma exchange absorption filter purifying system with square plasma storage tank Download PDF

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Publication number
CN103263705A
CN103263705A CN2013101688086A CN201310168808A CN103263705A CN 103263705 A CN103263705 A CN 103263705A CN 2013101688086 A CN2013101688086 A CN 2013101688086A CN 201310168808 A CN201310168808 A CN 201310168808A CN 103263705 A CN103263705 A CN 103263705A
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China
Prior art keywords
plasma
storage tank
purification
square
pulp storage
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CN2013101688086A
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Chinese (zh)
Inventor
李兰娟
李建州
夏列波
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Weihai Weigao Life Science & Technology Co Ltd
Zhejiang University ZJU
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Weihai Weigao Life Science & Technology Co Ltd
Zhejiang University ZJU
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Priority to CN2013101688086A priority Critical patent/CN103263705A/en
Publication of CN103263705A publication Critical patent/CN103263705A/en
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Abstract

The invention discloses a plasma exchange absorption filter purifying system with a square plasma storage tank. The plasma exchange absorption filter purifying system comprises a fractional plasma separation feedback circulating part and a plasma purification regeneration circulating part. A selective membrane plasma separator is used to separate fractional plasma, flow rate difference of plasma separation circulating and plasma purification circulating is built by the special square plasma storage tank, two-stage purification is arranged before and after the square plasma storage tank during purification circulating, primary bilirubin absorption columns are arranged before the square plasma storage tank, a high-pass filter and an activated carbon absorber are arranged after the square plasma storage tank for absorption filter purification, and plasma after multiple circulations is fed back to human bodies by means of separation feedback circulation exchange. By the system, autologous waste plasma generated during plasma exchange purification can be purified continuously, plasma use is reduced. By the two-stage absorption filter system, small molecules, medium-sized molecules, inflammatory factor combined with proteins and large-molecule toxin and the like which are generated by liver failure can be eliminated, and system purification efficiency can be increased.

Description

A kind of plasmapheresis absorption that is equipped with square pulp storage tank filters cleaning system
Technical field
The invention belongs to field of biomedicine technology, relate to a kind of medical apparatus and instruments and application process thereof, relate in particular to a kind of blood purification system and application process thereof that adopts displacement, absorption, filtration technology to combine.
Background technology
The blood purification technical development of artificial liver replacement therapy is swift and violent, and is at present domestic based on the composition replacement therapy of blood plasma, and external research focus is albumin dialysis adsorption system, and its representational method is molecular adsorbent recirculation system (MARS).This class methods ultimate principle is to utilize albumin liquid as dialysis solution in albumen dialysis circulation, make in the blood samples of patients and lps molecule protein bound toxin and other type, transfer in the albumin liquid by the MARS dialyzer, blood is purified, meanwhile, by dialysis, resin, activated carbon adsorption purify the circulation of protein liquid purifying regeneration, and protein liquid can be reused to contaminated albumin liquid.The MARS treatment is low excessively because of dialyzer exchange of toxins efficient, a large amount of human albumin finally are not fully utilized in the albumen decontamination cycle, shortage is to substance supplement such as patient's albumin, thrombins, clinical efficacy is subjected to certain influence, but its three circulation, the scheme that purifies by active carbon, resin absorption and hemodialysis really is worth using for reference.
Chinese patent application 200720058961.3 discloses a kind of albumen circulation and has adsorbed the filtration system.This system improves in the MARS system-based, but still adopts the albumin dialysis process of MARS, film to change efficient low excessively, even if follow-up purification method is improved, clean-up effect is still restricted.
And carry out hemodiafiltration with the similar Prometheus of MARS therapy system system again with after the composition separating plasma absorption, compare with the MARS system, significantly reduce the albumin consumption, but plasma separator is connected with transfusion filters and is carried out, increased the unstability of system's operation greatly, the clinical manipulation difficulty, and the extracorporeal circulation capacity is at least more than the 600ml, very big to patient with severe symptoms's hemodynamic effects, so do not obtain large scale application at home and abroad.
Domestic, be extensive use of the method for plasmapheresis, blood plasma supply at present is shortage very, and a plasmapheresis need use about fresh plasma 3000ml, and the blood plasma of the 3000ml that displaces then gives and abandoning, and wherein a large amount of beneficiating ingredients can not get effectively feeding back utilizing, the means that present unmatchful these discarded blood plasma are still recycled efficiently, feed back from the body displacement again after if can taking full advantage of discarded plasma purification, then can significantly reduce the consumption of clinical blood plasma, the more sufferer of effective treatment.
Summary of the invention
The present invention seeks at the prior art deficiency, blood purification methods such as displacement, filtration, absorption are combined by the blood plasma reservoir bag, a kind of novel blood purification system constructing plan is provided: plasmapheresis absorption filters cleaning system, in the hope of obtaining more desirable effect aspect the diseases such as treatment liver failure, multiple organ dysfunction syndrome.
The plasmapheresis absorption that is equipped with square pulp storage tank filters cleaning system, comprises that the composition separating plasma feeds back circulation and plasma purification regeneration cycle two parts, and composition separating plasma feedback cycles through square pulp storage tank and links to each other with the plasma purification regeneration cycle.
Described purifying regeneration circulation comprises one-level bilirubin adsorber, square pulp storage tank, circulating pump, high flux filter, the active carbon adsorber that links to each other in turn.
Described separating plasma feeds back blood pump, composition plasma separator, separating plasma pump that circulation comprises, returns stock pump and attached connecting line thereof.
Described square pulp storage tank is provided with the separated plasma import, purifies the bleeding from anus slurry inlet, purifies blood plasma outlet, the outlet of backflow blood plasma, the first unidirectional flap valve, the second unidirectional flap valve.
The blood plasma liquid port of export of described high flux filter is parallel with basic blood replacing liquid feeder.
Beneficial effect of the present invention is: 1. can effectively plasmapheresis be combined with blood purification means such as absorption, dialysis, both solve excessive this difficult problem of extracorporeal circulation capacity, can give full play to the purification advantage of various means again; 2. two-step purification is handled, the absorption of one-level low speed bilirubin, it is poor that secondary makes up inside and outside rate of circulating flow by square pulp storage tank, purify through high flux hemofiltration post and active carbon adsorption column at a high speed, can remove the toxin of blood plasma comprehensively, do not make and changing under the adsorption column situation, the detergent power of system more only has the system of simple high speed internal recycle more lasting; 3. square pulp storage tank has been realized the blood plasma decontamination cycle of repeatedly flowing through, and from the body recycling, effectively reduces clinical consumption demand for fresh plasma behind the plasma purification of realizing originally abandoning.
Description of drawings
Fig. 1 is the structural representation that is equipped with the plasmapheresis absorption filtration cleaning system of square pulp storage tank.
Fig. 2 is the structural representation of special-purpose square pulp storage tank.
Wherein, blood pump 1, composition plasma separator 2, separating plasma pump 3, return stock pump 4, one-level bilirubin adsorber 5, square pulp storage tank 6, circulating pump 7, high flux filter 8, active carbon adsorber 9, separated plasma import 10, purify bleeding from anus slurry inlet 11, purify blood plasma outlet 12, backflow blood plasma outlet 13, unidirectional flap valve 14,15, the first blood plasma apothecas 16, the second blood plasma apotheca 17, composition separating plasma feed back circulation A, plasma purification regeneration cycle B.
The specific embodiment
The present invention is described further below in conjunction with drawings and Examples.
Referring to Fig. 1, the plasmapheresis absorption that is equipped with square pulp storage tank filters cleaning system, it comprises that the composition separating plasma feeds back circulation A and plasma purification regeneration cycle B two parts, and composition separating plasma feedback cycles through square pulp storage tank 6 and links to each other with the plasma purification regeneration cycle.
The purifying regeneration circulation comprises one-level bilirubin adsorber 5, square pulp storage tank 6, circulating pump 7, high flux filter 8, the active carbon adsorber 9 that links to each other in turn.Separating plasma feeds back blood pump 1, composition plasma separator 2, separating plasma pump 3 that circulation comprises, returns stock pump 4 and attached connecting line thereof.Square pulp storage tank is provided with separated plasma import 10, purification bleeding from anus slurry inlet 11, purifies blood plasma outlet 12, backflow blood plasma outlet 13, unidirectional flap valve 14,15.
The blood plasma liquid port of export of high flux filter 8 is parallel with basic blood replacing liquid feeder.
The used connecting line of native system can adopt medical PVC to make, and more excellent scheme is internal diameter 3.4, external diameter 5.6mm, pump line internal diameter 6.5, external diameter 10.0mm.
Embodiment
Use special-purpose artificial liver therapeutic instrument to carry out plasmapheresis, the external blood flow speed 100-120ml/min that draws, enter the EC-40W of Asahi Chemical Industry composition plasma separator, composition blood plasma in the separating blood, and the replacement therapy of blood plasma that carries out with fresh plasma, the separation replacing velocity is 20-25ml/min, carries out earlier finishing the plasma exchange dosage about 1500ml about 1 hour.In the back half an hour of plasmapheresis, the discarded blood plasma that separates is through one-level bilirubin adsorber 5, enter the square pulp storage tank first blood plasma apotheca 16 through separated plasma import 10, unidirectional flap valve 14,15 valve are pressed off, the blood plasma storage all is stored in the first blood plasma apotheca 16, collects the discarded blood plasma of 400 ml.Because EC-40W film average pore size is 30nm, can significantly reduce the filtering of globulin, albumin bound toxin and other type lps molecule then are transferred to blood plasma with blood plasma by filtration and store in the Over-bag.Collected in the blood plasma high speed purifying regeneration cycle of moving behind the blood plasma, from blood plasma reservoir bag exocoel through purifying blood plasma outlet 15 with the flow velocity of 200ml/min flow through high flux blood filter and active carbon adsorber, after purifying, enter the second blood plasma apotheca 17, again the repeated multiple times decontamination cycle.The plasma purification circulation comprises one-level bilirubin adsorption column, a large amount of bilirubin, secondary high speed hemofiltration, activated carbon adsorption, small-molecular weight blood plasma toxin during the high pass filter can effectively be removed, and active carbon adsorber can effectively be removed albumin bound toxin and a large amount of liver failure inflammatory mediator etc., behind blood plasma reservoir bag circularly purifying, can discard the regeneration of blood plasma, make it to feed back human body by displacement again, and effectively reduce the required fresh plasma amount of plasmapheresis of finishing.The blood plasma that enters the second blood plasma apotheca 17 after the purification can substitute fresh plasma, finishes displacement with the speed of 20-25ml/min through backflow blood plasma outlet 13 outflows and feeds back.When steady statue, the existence of unidirectional flap valve makes that blood plasma does not mix with undressed blood plasma in the second blood plasma apotheca, and makes every milliliter of discarded blood plasma at least through just feeding back human body through inner chamber after 10 circulations by current difference.Make the interior purification efficiency of native system improve greatly.
Like this, carrying out during the operation of above-mentioned blood purification system, is hinge with square pulp storage tank, makes plasmapheresis be connected with the form of absorption filtration with parallel connection, can be so that it separately during independent operation, can not influence each other.Because the collection of the discarded blood plasma that provides in the plasmapheresis process is purification utilization again, both effectively solved not enough this difficult problem of clinical blood plasma supply, excessive this problem of extracorporeal circulation capacity when having overcome multiple complex treatment pattern again and carrying out simultaneously.
In addition, in the native system because of the existence of high flux filter 6, carry out the persistence hemofiltration, by regulating the solute concentration of displacement liquid, can effectively alleviate problems such as blood calcium reduction in the blood plasma that plasmapheresis brings, the rising of citric acid concentration, by regulating the flow-rate ratio of displacement liquid and discarded liquid, can reach the therapeutical effect of regulating water, electrolyte, acid-base balance.
What more than announce only is specific embodiments of the invention.All distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention all should be thought protection scope of the present invention.

Claims (5)

1. a plasmapheresis absorption that is equipped with square pulp storage tank filters cleaning system, it is characterized in that, it comprises that the composition separating plasma feeds back circulation and plasma purification regeneration cycle two parts, and composition separating plasma feedback cycles through square pulp storage tank (6) and links to each other with the plasma purification regeneration cycle.
2. the absorption of the plasmapheresis of the square pulp storage tank of outfit as claimed in claim 1 filters cleaning system, it is characterized in that described purifying regeneration circulation comprises one-level bilirubin adsorber (5), square pulp storage tank (6), circulating pump (7), high flux filter (8), the active carbon adsorber (9) that links to each other in turn.
3. the absorption of the plasmapheresis of the square pulp storage tank of outfit as claimed in claim 1 or 2 filters cleaning system, it is characterized in that described separating plasma feeds back blood pump (1), composition plasma separator (2), separating plasma pump (3) that circulation comprises, returns stock pump 4 and attached connecting line thereof.
4. the absorption of the plasmapheresis of the square pulp storage tank of outfit as claimed in claim 3 filters cleaning system, it is characterized in that described square pulp storage tank is provided with separated plasma import (10), purification bleeding from anus slurry inlet (11), purification blood plasma outlet (12), the outlet of backflow blood plasma (13), the first unidirectional flap valve (14), the second unidirectional flap valve (15).
5. the absorption of the plasmapheresis of the square pulp storage tank of outfit as claimed in claim 2 filters cleaning system, it is characterized in that the blood plasma liquid port of export of described high flux filter (8) is parallel with basic blood replacing liquid feeder.
CN2013101688086A 2013-05-09 2013-05-09 Plasma exchange absorption filter purifying system with square plasma storage tank Pending CN103263705A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019153848A1 (en) * 2018-02-08 2019-08-15 中南大学湘雅二医院 Versatile plasma purification system based on centrifugal plasma separation method

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4747952A (en) * 1984-02-24 1988-05-31 Kuraray Co., Ltd. Method and apparatus for plasma treatment
JPH08295630A (en) * 1980-02-05 1996-11-12 Takeda Chem Ind Ltd Plasma separation
CN2810611Y (en) * 2005-06-22 2006-08-30 浙江科锐生物科技有限公司 In-vitro artificial liver support system
CN101745158A (en) * 2008-12-10 2010-06-23 旭化成可乐丽医疗株式会社 System for removing virus and cytokine from blood
CN202078582U (en) * 2011-01-26 2011-12-21 苏州大学附属第一医院 Combined in-vitro artificial liver support treatment system
CN202699700U (en) * 2012-06-27 2013-01-30 游绍莉 Off-line hybrid bio-artificial liver support system (BALSS)
CN203354984U (en) * 2013-05-09 2013-12-25 浙江大学 Plasma exchange adsorption filtration purification system for preparing square plasma storage pond

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08295630A (en) * 1980-02-05 1996-11-12 Takeda Chem Ind Ltd Plasma separation
US4747952A (en) * 1984-02-24 1988-05-31 Kuraray Co., Ltd. Method and apparatus for plasma treatment
CN2810611Y (en) * 2005-06-22 2006-08-30 浙江科锐生物科技有限公司 In-vitro artificial liver support system
CN101745158A (en) * 2008-12-10 2010-06-23 旭化成可乐丽医疗株式会社 System for removing virus and cytokine from blood
CN202078582U (en) * 2011-01-26 2011-12-21 苏州大学附属第一医院 Combined in-vitro artificial liver support treatment system
CN202699700U (en) * 2012-06-27 2013-01-30 游绍莉 Off-line hybrid bio-artificial liver support system (BALSS)
CN203354984U (en) * 2013-05-09 2013-12-25 浙江大学 Plasma exchange adsorption filtration purification system for preparing square plasma storage pond

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019153848A1 (en) * 2018-02-08 2019-08-15 中南大学湘雅二医院 Versatile plasma purification system based on centrifugal plasma separation method

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Application publication date: 20130828