CN104524651A - Bilirubin adsorption system and regeneration method thereof - Google Patents
Bilirubin adsorption system and regeneration method thereof Download PDFInfo
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- CN104524651A CN104524651A CN201410789551.0A CN201410789551A CN104524651A CN 104524651 A CN104524651 A CN 104524651A CN 201410789551 A CN201410789551 A CN 201410789551A CN 104524651 A CN104524651 A CN 104524651A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
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Abstract
The invention discloses a bilirubin adsorption system and a regeneration method thereof. A blood power device and a plasma separator of the system are arranged on an input pipeline, the inlet end of a second pipeline and the inlet end of a third pipeline are connected to the outlet end of the input pipeline, a regenerated liquid supply device is connected to the inlet end of a fourth pipeline, the outlet end of the third pipeline and the outlet end of the fourth pipeline are connected to the inlet end of a strong base type anion exchange resin adsorber, and the inlet end of a first pipeline and the inlet end of a fifth pipeline are connected to the outlet end of the strong base type anion exchange resin adsorber. A waste liquid collecting device is arranged at the outlet end of the first pipeline, and the outlet end of the second pipeline and the outlet end of the fifth pipeline are connected to the inlet end of a collaborative blood purifier. By means of the system, under the premise that the effectiveness is guaranteed, the usage amount of the adsorbent of a plasma perfusion device of the type is reduced by one half, the bilirubin and bile acid are efficiently adsorbed, meanwhile, the production cost is greatly reduced, and the patient treatment cost can be effectively reduced.
Description
Technical field
The present invention relates to blood purification technology field, specifically, relate to a kind of bilirubin adsorption system, relate to a kind of renovation process of bilirubin adsorption system in addition.
Background technology
Hyperbilirubinemia refers to a kind of disease when serum bilirubin is greater than 171 μm of ol/ L, to be common in inside and outside various liver damage, liver the patients such as cholestasis clinically, the phenomenon that such patient exceeds standard with bile acid simultaneously.And too much bilirubin, bile acid easily cause cell death and increase the weight of hepatic injury, such as hyperbilirubinemia can make hepatopath that muddy stone in liver, biliary cirrhosis occur further, and even hepatocyte is liquefied or coagulation necrosis.Therefore effectively remove too much bilirubin, bile acid is the key for the treatment of this type of patient.Remove bilirubin clinically, the Therapeutic Method of bile acid has multiple, wherein blood purification therapy can promote bile excretion in patient body, reduce serum bilirubin and bile acid levels, other harmful substance can be removed again simultaneously, maintain normal internal milieu, prevent hepatocellular further infringement, thus widely used.Strong basic type anion-exchange resin is wherein adopted to carry out the effective way that plasma perfusion removes bilirubin, bile acid is proved to be clinical treatment hyperbilirubinemia, its principle is the ion exchange utilizing strong base ion exchange resin, thus the bilirubin of combined belt negative charge and bile acid, reach the effect of removing.The domestic and international anion exchange resin adsorber for removing bilirubin and bile acid medical expense is clinically costly at present, thus the plasma perfusion device that greatly limit the type promoting the use of commercially.
Summary of the invention
A technical problem to be solved by this invention is to provide a kind of bilirubin adsorption system efficiently, to realize adsorbing bilirubin and bile acid efficiently, reduces production cost simultaneously, effectively reduces patient treatment expense.
Another technical problem to be solved by this invention is the renovation process providing a kind of efficient bilirubin adsorption system, the regeneration of adsorption system can be realized in blood drainage process, its absorbability is restored, to realize adsorbing bilirubin and bile acid efficiently, reduce production cost simultaneously, effectively reduce patient treatment expense.
For solving above-mentioned first technical problem, present invention employs following technical scheme: design a kind of bilirubin adsorption system, comprise hemodynamics device, plasma separator, regenerated liquid feedway, strong basic type anion-exchange resin adsorber, waste collecting device, collaborative blood purification and connecting line, described strong basic type anion-exchange resin adsorber inside accommodates adsorbent;
Described connecting line comprises the first pipeline, the second pipeline, the 3rd pipeline, the 4th pipeline, the 5th pipeline and intake line, output pipe, adsorber upstream and adsorber downstream pipe, described first pipeline, the second pipeline, the 3rd pipeline, the 4th pipeline and the 5th pipeline are respectively arranged with pipe valve, and described adsorber upstream and adsorber downstream pipe are connected to arrival end and the port of export of described strong basic type anion-exchange resin adsorber;
Wherein, described hemodynamics device and plasma separator are located at described intake line, the arrival end of described second pipeline and the 3rd pipeline is connected to the port of export of described intake line, described regenerated liquid feedway is connected to the arrival end of described 4th pipeline, the port of export of described 3rd pipeline and the 4th pipeline is connected to the arrival end of described adsorber upstream, the arrival end of described first pipeline and the 5th pipeline is connected to the port of export of described adsorber downstream pipe, described waste collecting device is located at the port of export of described first pipeline, the port of export of described second pipeline and the 5th pipeline is connected to the arrival end of described output pipe, described collaborative blood purification is located at described output pipe.
From such scheme, bilirubin adsorption system of the present invention utilizes ion exchange and the quick adsorption feature of strong basic type anion-exchange resin, the regeneration of strong basic type anion-exchange resin is realized in perfusing course, its absorbability is restored, the consumption reducing the type plasma perfusion device adsorbent half when ensuring validity can be realized by this system, achieve efficient adsorption bilirubin and bile acid, significantly reduce production cost simultaneously, and can effectively reduce patient treatment expense.
With current domestic conventional domestic strong basic type anion-exchange resin adsorber about 3900 yuan/, import then more expensive, be about 5900 yuan/, if reduce the consumption of half adsorbent, obviously production cost can be reduced, this expense expenditure for needing the patient of at least use 1 adsorber weekly then reduces greatly, reduce the financial burden of patient, indirectly improve the quality of life of patient.
Further, described collaborative blood purification can be blood perfusion device or hemodialyzer.
Further, the amount of the adsorbent in described strong basic type anion-exchange resin adsorber is preferably 150mL ~ 180mL.In theory, the amount of adsorber internal adsorption agent is more, and the amount of its adsorb harmful components is more, but also will consider that a large amount of adsorbents brings the problem of safety reduction and production cost raising.Therefore the adsorbent filled in the bilirubin adsorption device circulated in the market is everlasting between 300 ~ 400mL, when there is efficient adsorption bilirubin performance in conjunction with the present invention, therefore preferred adsorbent is above-mentioned volume, the present invention can be made when ensuring validity to reduce the consumption of adsorbent half, reduce production cost, and can effectively reduce patient treatment expense.
Further, the blood chamber vol of described strong basic type anion-exchange resin adsorber is preferably 20 ~ 60mL.Because the present invention realizes the bilirubinic effect of efficient adsorption by the mechanism of regeneration, therefore certain blood plasma will inevitably be lost in regenerative process, therefore blood room volume is less, the blood plasma of waste will be fewer, more favourable to patient, but the too little effect that can affect again regeneration of blood room volume simultaneously, therefore preferred above-mentioned blood chamber vol.
Further, described regenerated liquid feedway comprises physiological saline solution bag and the normal saline in described physiological saline solution bag to be pumped into the tube pump in described strong basic type anion-exchange resin adsorber by described 4th pipeline by predetermined flow velocity.
For solving above-mentioned second technical problem, present invention employs following technical scheme: a kind of renovation process of bilirubin adsorption system, described bilirubin adsorption system comprises hemodynamics device, plasma separator, regenerated liquid feedway, strong basic type anion-exchange resin adsorber, waste collecting device, collaborative blood purification and connecting line, and described strong basic type anion-exchange resin adsorber inside accommodates adsorbent;
Described connecting line comprises the first pipeline, the second pipeline, the 3rd pipeline, the 4th pipeline, the 5th pipeline and intake line, output pipe, adsorber upstream and adsorber downstream pipe, described first pipeline, the second pipeline, the 3rd pipeline, the 4th pipeline and the 5th pipeline are respectively arranged with the first pipe valve, the second pipe valve, the 3rd pipe valve, the 4th pipe valve and the 5th pipe valve, described adsorber upstream and adsorber downstream pipe are connected to arrival end and the port of export of described strong basic type anion-exchange resin adsorber;
Wherein, described hemodynamics device and plasma separator are located at described intake line, the arrival end of described second pipeline and the 3rd pipeline is connected to the port of export of described intake line, described regenerated liquid feedway is connected to the arrival end of described 4th pipeline, the port of export of described 3rd pipeline and the 4th pipeline is connected to the arrival end of described adsorber upstream, the arrival end of described first pipeline and the 5th pipeline is connected to the port of export of described adsorber downstream pipe, described waste collecting device is located at the port of export of described first pipeline, the port of export of described second pipeline and the 5th pipeline is connected to the arrival end of described output pipe, described collaborative blood purification is located at described output pipe,
Wherein, described renovation process comprises the following steps:
A) when all pipe valves are closed, first open described 3rd pipe valve and the 5th pipe valve, keep all the other pipe valves to close, open described hemodynamics device and start to carry out blood drainage;
B) described second pipe valve sustained blood drain is opened, close described 3rd pipe valve and the 5th pipe valve, open described 4th pipe valve and the first pipe valve again, regenerated liquid is passed into described strong basic type anion-exchange resin adsorber to regenerate it by described regenerated liquid feedway;
C) close described 4th pipe valve and regenerated liquid feedway, and close described first pipe valve, open described 3rd pipe valve and the 5th pipe valve immediately and close the second pipe valve, proceeding blood drainage;
D) blood drainage is terminated.
From such scheme, the renovation process of bilirubin adsorption system of the present invention utilizes ion exchange and the quick adsorption feature of strong basic type anion-exchange resin, the regeneration of strong basic type anion-exchange resin is realized in blood drainage process, its absorbability is restored, the consumption reducing the type plasma perfusion device adsorbent half when ensuring validity can be realized by the method, achieve efficient adsorption bilirubin and bile acid, significantly reduce production cost simultaneously, and can effectively reduce patient treatment expense.The present invention, by adopting special many siphunculus road, can make blood drainage process and regenerative process carry out simultaneously.
Further, the blood drainage time in step a) is preferably 30 ~ 40min; In step b), the flow velocity of regenerated liquid is preferably no more than 300mL/min, and the recovery time is preferably no more than 40min; The blood drainage time in step c) is preferably 40-60min.Research finds, strong base ion exchange resin has the ability reaching adsorption equilibrium fast to electronegative material, therefore strong base ion exchange resin reduces gradually to bilirubinic absorbability after 30 minutes, after 60 minutes strong base ion exchange resin to bilirubinic absorbability substantially close to floor level.Therefore for different step a) with c), its blood drainage time is preferably the above-mentioned time.Because strong base ion exchange resin has the ability reaching adsorption equilibrium fast to electronegative material, therefore its basic holomorphosis can be made in 40 minutes, therefore be preferably the above-mentioned time for its recovery time of step b).
Further, in step b), the recovery time is preferably 20 ~ 30min.
Further, after described 4th pipe valve of closedown and regenerated liquid feedway, keep described first pipe valve to open, treat that the regenerated liquid of described strong basic type anion-exchange resin adsorber and upstream and downstream pipeline thereof drains and close described first pipe valve again.
Further, above-mentioned steps b) and c) can to repeat, adsorbent is regenerated again, improves adsorption effect.
Accompanying drawing explanation
Fig. 1 is the structural representation of a kind of embodiment of bilirubin adsorption system of the present invention.
Detailed description of the invention
To describe various embodiment of the present invention below in detail, embodiment wherein in conjunction with the accompanying drawings and describe hereinafter.Although the present invention will be described in conjunction with illustrative embodiments, be to be understood that and the invention is not restricted to these illustrative embodiments.On the contrary, the present invention not only comprises these embodiments, but also comprises various distortion, improvement.
Following embodiment all adopts the external hepatopathy plasma circulation mode of 2 hours to test, hepatopathy blood plasma consumption is that 2.5L(is equal to blood plasma number contained in a 60kg patient body), be loaded in clean glass container, whole experiment completes in super-clean bench, strong basic type anion-exchange resin used is that macroporous type polystyrene strong basic type anion-exchange resin is equal to resin, by detecting the concentration of hepatopathy plasma bilirubin and bile acid in different time glass container, and to convert adsorption rate according to following formula.
Bilirubin (or bile acid) adsorption rate=[(C
0-C
t)/C
0] × 100%
C
0---the concentration of hepatopathy blood plasma bilirubin (or bile acid) during beginning, μm ol/L;
C
t---the concentration of hepatopathy blood plasma bilirubin (or bile acid) during t time, μm ol/L.
Fig. 1 shows a kind of bilirubin adsorption system of the present invention, this system comprises hemodynamics device 7, plasma separator 8, physiological saline solution bag 9, tube pump 10, strong basic type anion-exchange resin adsorber 11, waste fluid bag 12, collaborative blood purification 13 and connecting line etc., the amount of the adsorbent wherein in strong basic type anion-exchange resin adsorber 11 is preferably 150mL ~ 180mL, and blood chamber vol is preferably 20 ~ 60mL.Tube pump 10 is for pumping into the physiological saline solution in physiological saline solution bag 9 in strong basic type anion-exchange resin adsorber 11 by predetermined flow velocity by connecting line.Collaborative blood purification 13 can adopt blood perfusion device, also can adopt hemodialyzer or other collaborative adnexa.
Described connecting line comprises the first pipeline 21, second pipeline 22, 3rd pipeline 23, 4th pipeline 24, 5th pipeline 25 and intake line 26, output pipe 29, adsorber upstream 27 and adsorber downstream pipe 28, first pipeline 21, second pipeline 22, 3rd pipeline 23, 4th pipeline 24 and the 5th pipeline 25 are respectively arranged with the first pipe valve 1, second pipe valve 2, 3rd pipe valve 3, 4th pipe valve 4 and the 5th pipe valve 5, adsorber upstream 27 and adsorber downstream pipe 28 are connected to arrival end and the port of export of strong basic type anion-exchange resin adsorber 11.
Wherein, hemodynamics device 7 and plasma separator 8 are located at intake line 26, the arrival end of the second pipeline 22 and the 3rd pipeline 23 is connected to the port of export of intake line 26, physiological saline solution bag 9 and tube pump 10 are connected to the arrival end of the 4th pipeline 24, the port of export of the 3rd pipeline 23 and the 4th pipeline 24 is connected to the arrival end of adsorber upstream 27, the arrival end of the first pipeline 21 and the 5th pipeline 25 is connected to the port of export of adsorber downstream pipe 28, waste fluid bag 12 is located at the port of export of the first pipeline 21, the port of export of the second pipeline 22 and the 5th pipeline is connected to the arrival end of output pipe 29, collaborative blood purification 13 is located on output pipe 29.
The renovation process of above-mentioned bilirubin adsorption system comprises the following steps:
A) when all pipe valves are closed, first open the 3rd pipe valve 3 and the 5th pipe valve 5, keep all the other pipe valves to close, open hemodynamics device 7 and start to carry out blood drainage, the blood drainage time is preferably 30 ~ 40min;
B) the second pipe valve 2 sustained blood drain is opened, close the 3rd pipe valve 3 and the 5th pipe valve 5, open the 4th pipe valve 4 and the first pipe valve 1 again, the physiological saline solution in physiological saline solution bag 9 is pumped into strong basic type anion-exchange resin adsorber 11 to regenerate it by the 4th pipeline 24 and adsorber upstream 27 by predetermined flow velocity by tube pump 10; The flow velocity of normal saline is preferably no more than 300mL/min, and the recovery time, more excellent was 20 ~ 30min preferably no more than 40min;
C) close the 4th pipe valve 4 and tube pump 10, and close the first pipe valve 1, open the 3rd pipe valve 3 and the 5th pipe valve 5 immediately and close the second pipe valve 2, proceed blood drainage, the blood drainage time is preferably 40-60min; In this step, after closedown the 4th pipe valve 4 and tube pump 10, preferably keep the first pipe valve 1 to open, treat that the normal saline of strong basic type anion-exchange resin adsorber 11 and upstream and downstream pipeline 27,28 thereof drains and close the first pipe valve 1 again;
D) as required, above-mentioned steps b can be repeated) and c);
E) blood drainage is terminated.
embodiment 1
The strong basic type anion-exchange resin adsorber (blood chamber vol is 40mL) that 150mL adsorbent is housed and the strong basic type anion-exchange resin adsorber (blood chamber vol is 110mL) that 330mL adsorbent is housed is selected to carry out the control experiment of external hepatopathy plasma circulation.Wherein the strong basic type anion-exchange resin adsorber of 150mL adopts regeneration, and the strong basic type anion-exchange resin adsorber of 330mL is without regeneration.Concrete operations are as follows:
The strong basic type anion-exchange resin adsorber of 150mL: a. is when all pipe valves are closed, first the 3rd pipe valve 3 and the 5th pipe valve 5 is opened, keep all the other pipe valves to close, open hemodynamics device 7 and start to carry out blood drainage, the blood drainage time is 40min; B. the second pipe valve 2 sustained blood drain is opened, close the 3rd pipe valve 3 and the 5th pipe valve 5, sustained blood drain after opening tube pump 10, open rapidly the 4th pipe valve 4 and the first pipe valve 1 again, the physiological saline solution of normal saline bag 9 is passed into strong basic type anion-exchange resin adsorber 11 regenerate it, physiological saline solution is 100mL/min by the flow velocity of tube pump 10, and the recovery time is 20min; C. the 4th pipe valve 4 and tube pump 10 is closed after closing the first pipe valve 1 immediately, open the 3rd pipe valve 3, first pipe valve 1 immediately and close the second pipe valve 2, normal saline in 4th pipeline and the 5th pipeline is drained, then close the first pipe valve 1 and open the 5th pipe valve 5 and continue circulation again, circulation time is 60min; D. end loop.
The strong basic type anion-exchange resin adsorber of 330mL: open the 3rd pipe valve 3 and the 5th pipe valve 5, all the other pipe valves are closed, and open hemodynamics device 7 and start blood drainage, terminate blood drainage after blood drainage 120min.
The strong basic type anion-exchange resin adsorber 11 recording 150mL is respectively 28.6% and 21.7% when 40min to the adsorption rate of bilirubin and bile acid, is respectively 58.7% and 48.8% when 120min to the adsorption rate of bilirubin and bile acid.
The strong basic type anion-exchange resin adsorber recording 330mL is respectively 61.5% and 52.6% when 120min to the adsorption rate of bilirubin and bile acid.
embodiment 2
The strong basic type anion-exchange resin adsorber (blood chamber vol is 50mL) that 180mL adsorbent is housed and the strong basic type anion-exchange resin adsorber (blood chamber vol is 110mL) that 330mL adsorbent is housed is selected to carry out the control experiment of external hepatopathy plasma circulation.Wherein the strong basic type anion-exchange resin adsorber of 180mL adopts regeneration, and the strong basic type anion-exchange resin adsorber of 330mL is without regeneration.Concrete operations are as follows:
A., when all pipe valves are closed, first open the 3rd pipe valve 3 and the 5th pipe valve 5, keep all the other pipe valves to close, open hemodynamics device 7 and start to carry out blood drainage, the blood drainage time is 40min; B. the second pipe valve 2 sustained blood drain is opened, close the 3rd pipe valve 3 and the 5th pipe valve 5, sustained blood drain after opening tube pump 10, open rapidly the 4th pipe valve 4 and the first pipe valve 1 again, the physiological saline solution of normal saline bag 9 is passed into strong basic type anion-exchange resin adsorber 11 regenerate it, physiological saline solution is 150mL/min by the flow velocity of tube pump 10, and the recovery time is 20min; C. the 4th pipe valve 4 and tube pump 10 is closed after closing the first pipe valve 1 immediately, open the 3rd pipe valve 3, first pipe valve 1 immediately and close the second pipe valve 2, normal saline in 4th pipeline and the 5th pipeline is drained, then close the first pipe valve 1 and open the 5th pipe valve 5 and continue circulation again, circulation time is 60min; D. end loop.
The strong basic type anion-exchange resin adsorber of 330mL: open the 3rd pipe valve 3 and the 5th pipe valve 5, all the other pipe valves are closed, and open hemodynamics device 7 and start blood drainage, terminate blood drainage after blood drainage 120min.
The strong basic type anion-exchange resin adsorber recording 180mL is respectively 30.6% and 25.7% when 40min to the adsorption rate of bilirubin and bile acid, is respectively 66.7% and 57.8% when 120min to the adsorption rate of bilirubin and bile acid.
The strong basic type anion-exchange resin adsorber recording 330mL is respectively 61.5% and 52.6% when 120min to the adsorption rate of bilirubin and bile acid.
embodiment 3
The strong basic type anion-exchange resin adsorber (blood chamber vol is 20mL) that 100mL adsorbent is housed and the strong basic type anion-exchange resin adsorber (blood chamber vol is 70mL) that 230mL adsorbent is housed is selected to carry out the control experiment of external hepatopathy plasma circulation.Wherein the strong basic type anion-exchange resin adsorber of 100mL adopts regeneration, and the strong basic type anion-exchange resin adsorber of 230mL is without regeneration.Concrete operations are as follows:
The strong basic type anion-exchange resin adsorber of 100mL: a. is when all pipe valves are closed, first the 3rd pipe valve 3 and the 5th pipe valve 5 is opened, keep all the other pipe valves to close, open hemodynamics device 7 and start to carry out blood drainage, the blood drainage time is 30min; B. the second pipe valve 2 sustained blood drain is opened, close the 3rd pipe valve 3 and the 5th pipe valve 5, sustained blood drain after opening tube pump 10, open rapidly the 4th pipe valve 4 and the first pipe valve 1 again, the physiological saline solution of normal saline bag 9 is passed into strong basic type anion-exchange resin adsorber 11 regenerate it, physiological saline solution is 50mL/min by the flow velocity of tube pump 10, and the recovery time is 30min; C. the 4th pipe valve 4 and tube pump 10 is closed after closing the first pipe valve 1 immediately, open the 3rd pipe valve 3, first pipe valve 1 immediately and close the second pipe valve 2, normal saline in 4th pipeline and the 5th pipeline is drained, then close the first pipe valve 1 and open the 5th pipe valve 5 and continue circulation again, circulation time is 60min; D. end loop.
The strong basic type anion-exchange resin adsorber of 230mL: open the 3rd pipe valve 3 and the 5th pipe valve 5, all the other pipe valves are closed, and open hemodynamics device 7 and start blood drainage, terminate blood drainage after blood drainage 120min.
The strong basic type anion-exchange resin adsorber recording 100mL is respectively 18.9% and 15.1% when 30min to the adsorption rate of bilirubin and bile acid, is respectively 43.6% and 39.8% when 120min to the adsorption rate of bilirubin and bile acid.
The strong basic type anion-exchange resin adsorber recording 230mL is respectively 46.5% and 41.6% when 120min to the adsorption rate of bilirubin and bile acid.
embodiment 4
Two strong basic type anion-exchange resin adsorbers (blood chamber vol is 40mL) that 150mL adsorbent is housed respectively are selected to carry out the control experiment of external hepatopathy plasma circulation.Wherein the strong basic type anion-exchange resin adsorber of first 150mL adopts regeneration, and the strong basic type anion-exchange resin adsorber of another 150mL is without regeneration.Concrete operations are as follows:
The strong basic type anion-exchange resin adsorber of the 150mL of regeneration: a. is when all pipe valves are closed, first the 3rd pipe valve 3 and the 5th pipe valve 5 is opened, keep all the other pipe valves to close, open hemodynamics device 7 and start to carry out blood drainage, the blood drainage time is 40min; B. the second pipe valve 2 sustained blood drain is opened, close the 3rd pipe valve 3 and the 5th pipe valve 5, sustained blood drain after opening tube pump 10, open rapidly the 4th pipe valve 4 and the first pipe valve 1 again, the physiological saline solution of normal saline bag 9 is passed into strong basic type anion-exchange resin adsorber 11 regenerate it, physiological saline solution is 100mL/min by the flow velocity of tube pump 10, and the recovery time is 20min; C. the 4th pipe valve 4 and tube pump 10 is closed after closing the first pipe valve 1 immediately, open the 3rd pipe valve 3, first pipe valve 1 immediately and close the second pipe valve 2, normal saline in 4th pipeline and the 5th pipeline is drained, then close the first pipe valve 1 and open the 5th pipe valve 5 and continue circulation again, circulation time is 60min; D. end loop.
Strong basic type anion-exchange resin adsorber without the 150mL of regeneration: open the 3rd pipe valve 3 and the 5th pipe valve 5, all the other pipe valves are closed, and open hemodynamics device 7 and start blood drainage, terminate blood drainage after blood drainage 120min.
The strong basic type anion-exchange resin adsorber recording the 150mL of regeneration is respectively 28.6% and 21.7% when 40min to the adsorption rate of bilirubin and bile acid, is respectively 58.7% and 48.8% when 120min to the adsorption rate of bilirubin and bile acid.
The strong basic type anion-exchange resin adsorber recorded without the 150mL of regeneration is respectively 36.7% and 32.6% when 120min to the adsorption rate of bilirubin and bile acid.
embodiment 5
Select the strong basic type anion-exchange resin adsorber (blood chamber vol is 50mL) that 180mL adsorbent is housed to carry out the control experiment of external hepatopathy plasma circulation, concrete operations are as follows:
A., when all pipe valves are closed, first open the 3rd pipe valve 3 and the 5th pipe valve 5, keep all the other pipe valves to close, open hemodynamics device 7 and start to carry out blood drainage, the blood drainage time is 30min; B. the second pipe valve 2 sustained blood drain is opened, close the 3rd pipe valve 3 and the 5th pipe valve 5, sustained blood drain after opening tube pump 10, open rapidly the 4th pipe valve 4 and the first pipe valve 1 again, the physiological saline solution of normal saline bag 9 is passed into strong basic type anion-exchange resin adsorber 11 regenerate it, physiological saline solution is 150mL/min by the flow velocity of tube pump 10, and the recovery time is 20min; C. the 4th pipe valve 4 and tube pump 10 is closed after closing the first pipe valve 1 immediately, open the 3rd pipe valve 3, first pipe valve 1 immediately and close the second pipe valve 2, normal saline in 4th pipeline and the 5th pipeline is drained, then close the first pipe valve 1 and open the 5th pipe valve 5 and continue circulation again, circulation time is 30min; Repeat b, step c twice successively; D. end loop.
The strong basic type anion-exchange resin adsorber recording 180mL is respectively 24.6% and 19.1% when 30min to the adsorption rate of bilirubin and bile acid, when 80min, 48.7% and 40.6% are respectively to the adsorption rate of bilirubin and bile acid, when 130min, 68.7% and 61.6% are respectively to the adsorption rate of bilirubin and bile acid, when 180min, 86.1% and 78.9% are respectively to the adsorption rate of bilirubin and bile acid.
As seen from the above-described embodiment, bilirubin adsorption system of the present invention utilizes ion exchange and the quick adsorption feature of strong basic type anion-exchange resin, the regeneration of strong basic type anion-exchange resin is realized in blood drainage process, its absorbability is restored, the consumption reducing the type plasma perfusion device adsorbent half when ensuring validity can be realized by this system, achieve efficient adsorption bilirubin and bile acid, significantly reduce production cost simultaneously, and can effectively reduce patient treatment expense.The present invention, by adopting special many siphunculus road, can make blood drainage process and regenerative process carry out simultaneously.
Above-described is only the preferred embodiment of the present invention, it should be pointed out that for the person of ordinary skill of the art, and without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.
Claims (10)
1. a bilirubin adsorption system, it is characterized in that, comprise hemodynamics device, plasma separator, regenerated liquid feedway, strong basic type anion-exchange resin adsorber, waste collecting device, collaborative blood purification and connecting line, described strong basic type anion-exchange resin adsorber inside accommodates adsorbent;
Described connecting line comprises the first pipeline, the second pipeline, the 3rd pipeline, the 4th pipeline, the 5th pipeline and intake line, output pipe, adsorber upstream and adsorber downstream pipe, described first pipeline, the second pipeline, the 3rd pipeline, the 4th pipeline and the 5th pipeline are respectively arranged with pipe valve, and described adsorber upstream and adsorber downstream pipe are connected to arrival end and the port of export of described strong basic type anion-exchange resin adsorber;
Wherein, described hemodynamics device and plasma separator are located at described intake line, the arrival end of described second pipeline and the 3rd pipeline is connected to the port of export of described intake line, described regenerated liquid feedway is connected to the arrival end of described 4th pipeline, the port of export of described 3rd pipeline and the 4th pipeline is connected to the arrival end of described adsorber upstream, the arrival end of described first pipeline and the 5th pipeline is connected to the port of export of described adsorber downstream pipe, described waste collecting device is located at the port of export of described first pipeline, the port of export of described second pipeline and the 5th pipeline is connected to the arrival end of described output pipe, described collaborative blood purification is located at described output pipe.
2. bilirubin adsorption system according to claim 1, is characterized in that: described collaborative blood purification is blood perfusion device or hemodialyzer.
3. bilirubin adsorption system according to claim 1, is characterized in that: the amount of the adsorbent in described strong basic type anion-exchange resin adsorber is 150mL ~ 180mL.
4. bilirubin adsorption system according to claim 1, is characterized in that: the blood chamber vol of described strong basic type anion-exchange resin adsorber is 20 ~ 60mL.
5. bilirubin adsorption system according to claim 1, is characterized in that: described regenerated liquid feedway comprises physiological saline solution bag and the normal saline in described physiological saline solution bag to be pumped into the tube pump in described strong basic type anion-exchange resin adsorber by described 4th pipeline by predetermined flow velocity.
6. the renovation process of a bilirubin adsorption system, described bilirubin adsorption system comprises hemodynamics device, plasma separator, regenerated liquid feedway, strong basic type anion-exchange resin adsorber, waste collecting device, collaborative blood purification and connecting line, and described strong basic type anion-exchange resin adsorber inside accommodates adsorbent;
Described connecting line comprises the first pipeline, the second pipeline, the 3rd pipeline, the 4th pipeline, the 5th pipeline and intake line, output pipe, adsorber upstream and adsorber downstream pipe, described first pipeline, the second pipeline, the 3rd pipeline, the 4th pipeline and the 5th pipeline are respectively arranged with the first pipe valve, the second pipe valve, the 3rd pipe valve, the 4th pipe valve and the 5th pipe valve, described adsorber upstream and adsorber downstream pipe are connected to arrival end and the port of export of described strong basic type anion-exchange resin adsorber;
Wherein, described hemodynamics device and plasma separator are located at described intake line, the arrival end of described second pipeline and the 3rd pipeline is connected to the port of export of described intake line, described regenerated liquid feedway is connected to the arrival end of described 4th pipeline, the port of export of described 3rd pipeline and the 4th pipeline is connected to the arrival end of described adsorber upstream, the arrival end of described first pipeline and the 5th pipeline is connected to the port of export of described adsorber downstream pipe, described waste collecting device is located at the port of export of described first pipeline, the port of export of described second pipeline and the 5th pipeline is connected to the arrival end of described output pipe, described collaborative blood purification is located at described output pipe,
It is characterized in that, described renovation process comprises the following steps:
A) when all pipe valves are closed, first open described 3rd pipe valve and the 5th pipe valve, keep all the other pipe valves to close, open described hemodynamics device and start to carry out blood drainage;
B) described second pipe valve sustained blood drain is opened, close described 3rd pipe valve and the 5th pipe valve, open described 4th pipe valve and the first pipe valve again, regenerated liquid is passed into described strong basic type anion-exchange resin adsorber to regenerate it by described regenerated liquid feedway;
C) close described 4th pipe valve and regenerated liquid feedway, and close described first pipe valve, open described 3rd pipe valve and the 5th pipe valve immediately and close the second pipe valve, proceeding blood drainage;
D) blood drainage is terminated.
7. the renovation process of bilirubin adsorption system according to claim 6, is characterized in that: the blood drainage time in step a) is 30 ~ 40min; In step b), the flow velocity of regenerated liquid is no more than 300mL/min, and the recovery time is no more than 40min; The blood drainage time in step c) is 40-60min.
8. the renovation process of bilirubin adsorption system according to claim 7, it is characterized in that: in step b), the recovery time is 20 ~ 30min.
9. the renovation process of bilirubin adsorption system according to claim 6, it is characterized in that: after described 4th pipe valve of closedown and regenerated liquid feedway, keep described first pipe valve to open, treat that the regenerated liquid of described strong basic type anion-exchange resin adsorber and upstream and downstream pipeline thereof drains and close described first pipe valve again.
10. the renovation process of bilirubin adsorption system as claimed in claim 6, is characterized in that: repeated execution of steps b) and c).
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