CN205073379U - Plasma exchange adsorbs filters clean system - Google Patents

Plasma exchange adsorbs filters clean system Download PDF

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CN205073379U
CN205073379U CN201520767153.9U CN201520767153U CN205073379U CN 205073379 U CN205073379 U CN 205073379U CN 201520767153 U CN201520767153 U CN 201520767153U CN 205073379 U CN205073379 U CN 205073379U
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plasma
blood
pipeline
plasmapheresis
pump
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田沂
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Abstract

The utility model discloses a plasma exchange adsorbs filters clean system, include the plasma separator and be used for the human blood recirculation line of blood feedback through plasma separator after -separating, plasma exchange adsorbs filters clean system includes still that plasma filters the pipeline, plasma separator and plasma are filtered and are provided with parallelly connected plasma between the pipeline and put tube replacement way and plasma absorption pipeline, plasma filter the pipeline terminal with the blood recirculation line is connected, the utility model has the advantages of advantage that can the various blood purification techniquess of full play to can carry out slow type plasma exchange according to clinical needs adsorbs synchronous operation or plasma exchange and plasma absorption sequential therapy with plasma.

Description

A kind of plasmapheresis absorption filtration cleaning system
Technical field
This utility model relates to the Medical Instruments for blood purification, particularly relates to a kind of plasmapheresis absorption filtration cleaning system, is specially adapted to hepatic failure patients, multiple organ dysfunction syndrome patient.
Background technology
At present, the blood purification technology development of artificial liver replacement therapy rapidly, defines and is adsorbed as the main multiple technical scheme differed from one another with plasmapheresis, plasma adsorption, hemofiltration, albumin dialysis.Albumin dialysis absorption with molecular adsorbent recirculation system (MARS) and continuous albumin cleaning system (CAPS) for representative, its operation principle utilizes the 20% albumin liquid of 500 ~ 600ml as the medium of combination, transport protein toxin in albumin dialysis circulation, make the lps molecule with protein bound toxin and other types in blood samples of patients, transfer in albumin liquid by MARS or CAPS dialyzer, circulate through protein liquid purifying regeneration, purified by dialysis, resin and activated carbon adsorption successively, the albumin liquid after purification can be reused again; Until resin and active carbon adsorber absorption reach capacity, postalbumin cannot re-use and abandon.Because MARS and CAPS is the indirect attachment adopting albumin transhipment toxin and realize adsorber, affects by dialyzer exchange of toxins efficiency simultaneously, make MARS and CAPS remove the efficiency of toxin not as plasma adsorption; And the same with plasma adsorption, can not supplement albumin and thrombin, not be suitable for the hepatic failure patients that coagulation function is badly damaged, clinical efficacy also can be under some influence; And each medical expense of MARS and CAPS is up to about 20,000 yuan, also can consume a large amount of albumin, be difficult to promote on a large scale at home.The blood purification technology of domestic artificial liver replacement therapy is based on plasmapheresis, plasmapheresis can be removed protein binding toxin, supplement albumin and thrombin, but limited to soluble toxins Scavenging activity, and Clinical practice is subject to the under-supply restriction of blood plasma.Slow type plasmapheresis, by the plasmapheresis speed that slows down, to allow between tissue the toxin of savings enter blood more fully and is set to and changes, can remove the protein binding toxins such as bilirubin more than plasmapheresis, reduces bilirubinic bounce-back after patient treatment.Hemofiltration because of filter membrane aperture larger than hemodialyzer film, can remove middle molecule toxins more, hemodynamics is more stable, is therefore more suitable for hepatic failure patients than dialysis.If plasmapheresis, plasma adsorption are combined with filtration, both albumin and thrombin can be supplemented, and by autologous feedback again after discarded plasma purification, then the consumption of clinical blood can be can greatly reduced again, fully can meet again the state of an illness needs of hepatic failure patients, the more sufferer of effective treatment.
Chinese patent literature CN203280813U discloses a kind of plasmapheresis absorption filtration cleaning system being equipped with slurry storing bag, plasmapheresis, plasma adsorption combine with plasma dialysis by this system, first carry out 1 hour plasmapheresis, then sequentially again 5 hours plasma adsorption and plasma dialysis is carried out, but it forms complexity, need the special purification instrument having 6 pumps or two Daeporis to lead to apparatus for purifying blood during operation to work, Clinical practice is restricted simultaneously.In addition, this device can only carry out plasmapheresis and plasma adsorption sequential therapy, and can not the slow type plasmapheresis of synchronization implementation and plasma sorption therapy; And, in its high speed purifying regeneration cycle, the plasma flow rate of plasma adsorption, dialysis reaches 200ml/min, although the efficiency that plasma dialysis removes soluble small molecular material can be improved, but too fast plasma flow rate is also not suitable for carrying out plasma adsorption, protein binding toxin is short for the time of contact as the macromole such as bilirubin and other middle molecule toxinses and adsorber, adsorption efficiency can be restricted, and for hepatic failure patients, removing is large, Middle molecule toxicant is even more important to improving patient's prognosis.
Utility model content
The technical problems to be solved in the utility model overcomes the deficiencies in the prior art, a kind of plasmapheresis, plasma adsorption filtrations with blood plasma is provided to combine, give full play to the treatment advantage of various blood purification technology, slow type plasmapheresis and plasma adsorption synchronous operation can be carried out according to clinical needs, also can carry out the plasmapheresis absorption filtration cleaning system of plasmapheresis and plasma adsorption sequential therapy.
For solving the problems of the technologies described above, this utility model is by the following technical solutions: a kind of plasmapheresis absorption filtration cleaning system, comprise plasma separator and for the blood recovery pipeline by the blood recovery human body after plasma separator is separated, described plasmapheresis absorption filtration cleaning system also comprises blood plasma and filters pipeline, described plasma separator and blood plasma filter between pipeline and are provided with plasmapheresis line in parallel and plasma adsorption pipeline, and described blood plasma filters line end and is connected with described blood recovery pipeline.
Further improvement as technique scheme:
Described plasmapheresis line is provided with the first blood plasma pump, described plasma adsorption pipeline is provided with the second blood plasma pump, described first blood plasma pump is equipped with fresh plasma bag, described blood plasma filters on pipeline and is provided with high flux filter, filtration liquid pump and blood plasma heating component successively, described filtration liquid pump is equipped with basic blood replacing liquid bag, and described blood plasma heating component is connected with described blood recovery pipeline.
Described first blood plasma pump comprises fresh plasma pipeline in parallel and discarded plasma tube, described fresh plasma pipeline one end is connected with described fresh plasma bag, the other end is connected with described high flux filter, described discarded plasma tube one end is connected with the composition plasma outlet port of described plasma separator, and the other end is connected with discarded blood plasma bucket.
Described plasma adsorption pipeline comprises the resin absorption device and active carbon adsorber that are connected, and described resin absorption device is connected with the composition plasma outlet port of described plasma separator, and described active carbon adsorber is connected with described high flux filter through the second blood plasma pump.
The input of described plasma separator connects the first liquid kettle, blood pump and blood collection pipeline successively, described blood recovery pipeline is equipped with the second liquid kettle.
Pipeline after described first liquid kettle, the second liquid kettle and plasmapheresis line and plasma adsorption pipeline converge is equipped with pressure monitoring connection tube.
Also comprise heparin pump, described first liquid kettle is connected with described heparin pump.
Compared with prior art, the utility model has the advantage of: plasmapheresis, plasma adsorption filter with blood plasma and combine by plasmapheresis absorption filtration cleaning system disclosed in this utility model, can according to clinical needs by regulating break-make, the operation of plasmapheresis line and plasma adsorption pipeline, carry out slow type plasmapheresis and plasma adsorption synchronous operation, also can carry out plasmapheresis and plasma adsorption sequential therapy, give full play to the treatment advantage of various blood purification means; When synchronously carrying out slow type plasmapheresis and plasma sorption therapy, namely saving blood plasma, in turn enhancing the Scavenging activity of contratoxin, effectively alleviate the clinical demand consumption to fresh plasma; Filter except the soluble toxins except removing in hepatic failure patients blood plasma with the blood plasma of plasmapheresis, plasma adsorption synchronous operation, the conserving liquid in supplementary fresh plasma can also be removed, maintain water-electrolyte balance, avoid fresh plasma to replace and feed back the environment disorder and unbalanced syndrome that cause.
Accompanying drawing explanation
Fig. 1 is the structural representation of this utility model plasmapheresis absorption filtration cleaning system.
Fig. 2 is the structural representation of plasmapheresis line and plasma adsorption pipeline in this utility model.
In figure, each label represents: 1, blood collection pipeline; 2, blood pump; 3, the first liquid kettle; 4, plasma separator; 5, blood recovery pipeline; 6, the second liquid kettle; 7, blood plasma filters pipeline; 8, plasmapheresis line; 9, plasma adsorption pipeline; 91, resin absorption device; 92, active carbon adsorber; 10, the first blood plasma pump; 101, fresh plasma pipeline; 102, discarded plasma tube; 11, the second blood plasma pump; 13, high flux filter; 14, liquid pump is filtered; 15, blood plasma heating component; 16, pressure monitoring connection tube; 17, heparin pump; 18, fresh plasma bag; 19, basic blood replacing liquid bag; 21, discarded blood plasma bucket; 22, waste liquid barrel.
Detailed description of the invention
Below with reference to Figure of description and specific embodiment, this utility model is described in further details.
As depicted in figs. 1 and 2, the plasmapheresis absorption filtration cleaning system of the present embodiment, comprise plasma separator 4 and for the blood recovery pipeline 5 by the blood recovery human body after plasma separator 4 is separated, plasmapheresis absorption filtration cleaning system also comprises blood plasma and filters pipeline 7, plasma separator 4 and blood plasma filter between pipeline 7 and are provided with plasmapheresis line 8 in parallel and plasma adsorption pipeline 9, and blood plasma filters pipeline 7 end and is connected with blood recovery pipeline 5.
In the present embodiment, plasmapheresis line 8 is provided with the first blood plasma pump 10, plasma adsorption pipeline 9 is provided with the second blood plasma pump 11, first blood plasma pump 10 is equipped with fresh plasma bag 18, blood plasma filters on pipeline 7 and is provided with high flux filter 13, filtration liquid pump 14 and blood plasma heating component 15 successively, filter liquid pump 14 and be equipped with basic blood replacing liquid bag 19, blood plasma heating component 15 is connected with blood recovery pipeline 5.
In the present embodiment, first blood plasma pump 10 comprises fresh plasma pipeline 101 in parallel and discarded plasma tube 102, fresh plasma pipeline 101 one end is connected with fresh plasma bag 18, the other end is connected with high flux filter 13, discarded plasma tube 102 one end is connected with the composition plasma outlet port of plasma separator 4, and the other end is connected with discarded blood plasma bucket 21.Concrete fresh plasma pipeline 101 left end adopts plug-in type interface to be connected with fresh plasma bag 18 as shown in Figure 2, and right-hand member first converges with the pipeline after the second blood plasma pump 11 and is connected with high flux filter 13; Discarded plasma tube 102 left end is connected with the composition plasma outlet port of plasma separator 4, and right-hand member is connected with discarded blood plasma bucket 21.
In the present embodiment, plasma adsorption pipeline 9 comprises the resin absorption device 91 and active carbon adsorber 92 that are connected, and resin absorption device 91 is connected with the composition plasma outlet port of plasma separator 4, and active carbon adsorber 92 is connected with high flux filter 13 through the second blood plasma pump 11.
In the present embodiment, the input of plasma separator 4 connects the first liquid kettle 3, blood pump 2 and blood collection pipeline 1 successively, blood recovery pipeline 5 is equipped with the second liquid kettle 6.
In the present embodiment, the pipeline after the first liquid kettle 3, second liquid kettle 6 and plasmapheresis line 8 converge with plasma adsorption pipeline 9 is equipped with pressure monitoring connection tube 16.
In the present embodiment, plasmapheresis absorption filtration cleaning system also comprises heparin pump 17, and the first liquid kettle 3 is connected with heparin pump 17.
The using method of the plasmapheresis absorption filtration cleaning system of the present embodiment is as follows:
Use has blood pump 2, first blood plasma pump 10, second blood plasma pump 11 and the blood purification instrument filtering liquid pump 14 totally four pumps carry out these treatments, by blood pump 2, extracorporeal blood drain is entered plasma separator 4(and adopt the clear EC-4A plasma cure unit in river), draw blood speed 100ml/min ~ 120ml/min, composition blood plasma in plasma separator 4 separating blood, because its membrane aperture is less, limit the filtration of macromolecular globulin and thrombin, albumin bound toxin and other types lps molecule then leach with blood plasma, thus significantly can reduce leaching of globulin and thrombin, avoid being adsorbed by resin absorption device 91 and active carbon adsorber 92 and losing, the adsorption affecting resin absorption device 91 and active carbon adsorber 92 pairs of protein binding toxins can be avoided again.The speed that leaches of blood plasma is controlled by the first blood plasma pump 10 and the second blood plasma pump 11, and takes this to realize slow type plasmapheresis and plasma adsorption synchronous operation, or the adjustable blood purification treatment of plasmapheresis and the sequential operation of plasma adsorption.If carry out preceding paragraph treatment (slow type plasmapheresis and plasma adsorption synchronous operation), the plasma flow rate then arranging the first blood plasma pump 10 plasmapheresis is 5ml/min, the two-tube synchronous equal amount blood plasma that realizes of the plasmapheresis pipe controlled by the first blood plasma pump 10 is slowly replaced, the plasma flow rate of the second blood plasma pump 11 plasma adsorption is 25ml/min, blood plasma sequentially passes through resin absorption device 91 and active carbon adsorber 92, effectively can remove albumin bound toxin and liver failure Middle molecule inflammatory mediator; If carry out consequent treatment (plasmapheresis and the sequential operation of plasma adsorption), then first run the first blood plasma pump 10, plasma flow rate is that 30ml/min carries out plasmapheresis, and the second blood plasma pump 11 is adjusted to 0ml/min; After plasmapheresis completes, then stop the operation of the first blood plasma pump 10, flow velocity is adjusted to 0ml/min, the plasma flow rate of the second blood plasma pump 11 is adjusted to 30ml/min and carries out plasma adsorption.High flux filter 13 is entered with the speed of 30ml/min after blood plasma after the fresh plasma of the displacement controlled by the first blood plasma pump 10 and/or the absorption that controlled by the second blood plasma pump 11 converges, filter liquid pump 14(identical with the structure of the first blood plasma pump 10, also be double pipe structure, comprise basic blood replacing liquid pipeline and waste-solution line, repeat no more) then carry out blood plasma filtration with the speed of 24ml/min, leach moisture and soluble toxins in blood plasma, synchronous equal amount supplements basic blood replacing liquid, blood plasma filters the Middle molecule can effectively removed in blood plasma, micromolecular water dissolubility inflammatory mediator, and citrate concentration in blood plasma that plasmapheresis causes can be alleviated raise and the problem such as blood calcium reduction, correct Electrolyte imbalance and acid base imbalance, flowing through after the blood plasma of high flux filter 13 and basic blood replacing liquid converge is heated to after normal physiological body temperature 37 DEG C through blood plasma heating component 15, human body is fed back through blood recovery pipeline 5 after converging with the blood flowing through plasma separator 4.
The plasmapheresis absorption filtration cleaning system of the present embodiment can have blood pump 2, first blood plasma pump 10, second blood plasma pump 11 at one and filter on the normal blood purification instrument of liquid pump 14 totally four pumps and realizes plasmapheresis, absorption and filtering therapy, comprehensive removing protein binding toxin and soluble toxins, and the benefit materials such as the albumin that supplementary liver failure lacks and thrombin, regulate Water-Electrolyte and acid-base balance.Compared with plasmapheresis, both saved blood plasma, and toxicant can be removed more again; Compared with MARS, CAPS, directly adsorbed from being become by albumin indirect attachment by patients blood plasma, its adsorption is more excellent, and makes up the defect that these two kinds of purification styles can not supplement albumin and thrombin; In addition, plasma adsorption keeps suitable plasma flow rate, fully can ensure the time of contact of blood plasma and adsorbing material, improves the efficiency of plasma adsorption.
Although this utility model discloses as above with preferred embodiment, but and be not used to limit this utility model.Any those of ordinary skill in the art, when not departing from technical solutions of the utility model scope, the technology contents of above-mentioned announcement all can be utilized to make many possible variations and modification to technical solutions of the utility model, or be revised as the Equivalent embodiments of equivalent variations.Therefore, every content not departing from technical solutions of the utility model, according to this utility model technical spirit to any simple modification made for any of the above embodiments, equivalent variations and modification, all should drop in the scope of technical solutions of the utility model protection.

Claims (7)

1. a plasmapheresis absorption filtration cleaning system, comprise plasma separator (4) and for by the blood recovery pipeline (5) of blood recovery human body after plasma separator (4) is separated, it is characterized in that: described plasmapheresis absorption filtration cleaning system also comprises blood plasma and filters pipeline (7), described plasma separator (4) and blood plasma filter between pipeline (7) and are provided with plasmapheresis line (8) in parallel and plasma adsorption pipeline (9), and described blood plasma filters pipeline (7) end and is connected with described blood recovery pipeline (5).
2. plasmapheresis absorption filtration cleaning system according to claim 1, it is characterized in that: described plasmapheresis line (8) is provided with the first blood plasma pump (10), described plasma adsorption pipeline (9) is provided with the second blood plasma pump (11), described first blood plasma pump (10) is equipped with fresh plasma bag (18), described blood plasma filters on pipeline (7) and is provided with high flux filter (13) successively, filter liquid pump (14) and blood plasma heating component (15), described filtration liquid pump (14) is equipped with basic blood replacing liquid bag (19), described blood plasma heating component (15) is connected with described blood recovery pipeline (5).
3. plasmapheresis absorption filtration cleaning system according to claim 2, it is characterized in that: described first blood plasma pump (10) comprises fresh plasma pipeline (101) in parallel and discarded plasma tube (102), described fresh plasma pipeline (101) one end is connected with described fresh plasma bag (18), the other end is connected with described high flux filter (13), described discarded plasma tube (102) one end is connected with the composition plasma outlet port of described plasma separator (4), and the other end is connected with discarded blood plasma bucket (21).
4. plasmapheresis absorption filtration cleaning system according to claim 2, it is characterized in that: described plasma adsorption pipeline (9) comprises the resin absorption device (91) and active carbon adsorber (92) that are connected, described resin absorption device (91) is connected with the composition plasma outlet port of described plasma separator (4), and described active carbon adsorber (92) is connected with described high flux filter (13) through the second blood plasma pump (11).
5. plasmapheresis absorption filtration cleaning system according to any one of claim 1 to 4, it is characterized in that: the input of described plasma separator (4) connects the first liquid kettle (3), blood pump (2) and blood collection pipeline (1) successively, described blood recovery pipeline (5) is equipped with the second liquid kettle (6).
6. plasmapheresis absorption filtration cleaning system according to claim 5, is characterized in that: the pipeline after described first liquid kettle (3), the second liquid kettle (6) and plasmapheresis line (8) and plasma adsorption pipeline (9) converge is equipped with pressure monitoring connection tube (16).
7. plasmapheresis absorption filtration cleaning system according to claim 5, is characterized in that: also comprise heparin pump (17), and described first liquid kettle (3) is connected with described heparin pump (17).
CN201520767153.9U 2015-09-30 2015-09-30 Plasma exchange adsorbs filters clean system Active CN205073379U (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105771014A (en) * 2016-03-29 2016-07-20 艾沃生物科技(苏州)有限公司 Plasma filter capable of adsorbing OFR (oxygen free radical)
CN106377812A (en) * 2016-11-01 2017-02-08 中南大学湘雅二医院 Plasma circulation acceleration purifying system
CN107583120A (en) * 2017-09-20 2018-01-16 中南大学湘雅二医院 A kind of plasma exchange dialysis adsorption system
CN108310503A (en) * 2018-02-08 2018-07-24 中南大学湘雅二医院 A kind of Almightiness type plasma purification system based on centrifugal separation plasma method
CN110613869A (en) * 2019-10-24 2019-12-27 成都市佳颖医用制品有限公司 Plasma replacement adsorption system

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105771014A (en) * 2016-03-29 2016-07-20 艾沃生物科技(苏州)有限公司 Plasma filter capable of adsorbing OFR (oxygen free radical)
CN106377812A (en) * 2016-11-01 2017-02-08 中南大学湘雅二医院 Plasma circulation acceleration purifying system
CN106377812B (en) * 2016-11-01 2019-05-17 中南大学湘雅二医院 A kind of plasma circulation acceleration purification system
CN107583120A (en) * 2017-09-20 2018-01-16 中南大学湘雅二医院 A kind of plasma exchange dialysis adsorption system
CN107583120B (en) * 2017-09-20 2024-05-14 中南大学湘雅二医院 Plasma exchange dialysis adsorption system
CN108310503A (en) * 2018-02-08 2018-07-24 中南大学湘雅二医院 A kind of Almightiness type plasma purification system based on centrifugal separation plasma method
CN110613869A (en) * 2019-10-24 2019-12-27 成都市佳颖医用制品有限公司 Plasma replacement adsorption system

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