CN108310503A - A kind of Almightiness type plasma purification system based on centrifugal separation plasma method - Google Patents
A kind of Almightiness type plasma purification system based on centrifugal separation plasma method Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3687—Chemical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0415—Plasma
Abstract
The invention discloses a kind of Almightiness type plasma purification systems based on centrifugal separation plasma method, including plasmapheresis device and plasma dialysis accepted filtered absorption device, the plasmapheresis device includes centrifugal plasma separator, the plasma purification system further includes blood plasma transfer device, the blood plasma transfer device includes blood plasma transfering bag and useless slurry bag, blood plasma transfer conduit is equipped between the blood plasma output end of the plasmapheresis device and the blood plasma transfering bag, blood plasma discharge line is equipped between the blood plasma transfering bag and the useless slurry bag, plasma circulation pipeline is equipped between the output end of the plasma dialysis accepted filtered absorption device and the blood plasma discharge line.The plasma purification system of the present invention can give full play to centrifugal plasma displacement, plasma dialysis filters, the advantage of the dual adsorbing therapy of blood plasma, and meet centrifugal plasma displacement, plasma dialysis filtration and plasma adsorption to different plasma flow rate demands, have many advantages, such as function more comprehensively, the scope of application it is wider.
Description
Technical field
The present invention relates to Medical Instruments for blood purification more particularly to a kind of based on the all-round of centrifugal separation plasma method
Type plasma purification system（Versatile plasma purification system, VPPS）.
Background technology
Acute hepatic failure or acute-on-chronic liver failure state of an illness weight and rapid, the easy complicated with multiple system organ failure that is in progress, it is short
If disease progression cannot be prevented in the phase, by threat to life, urgent liver transfer operation is needed.Acute or acute-on-chronic liver failure patient's body
There are a large amount of toxin, and with coagulation disorders, late period hepatic failure patients hemorrhagic tendency is even more serious.Artificial liver is that one kind is used for
Treat the blood purification method of liver failure.Domestic and international basic artificial liver method has 4 kinds at present：Plasma exchange, blood plasma are inhaled
Attached, haemodialysis and blood filtering.Artificial liver in treatment is carried out to serious hepatic failure patients, the risk of its bleeding should be scrupled, again
Each toxoid accumulated in vivo, including protein binding toxin and soluble toxins are removed comprehensively.Different blood purification modes
The hepatic failure toxin of removing is different, and combination therapy can remove more toxin, enhances clean-up effect.
Albumin dialysis is adsorbed with molecular adsorbent recirculation system（MARS）To represent, operation principle is saturating in albumin
20% albumin liquid is utilized in analysis cycle（500~600ml）As combine, transport protein toxin medium, make in blood samples of patients with
Protein bound toxin and other kinds of lps molecule, are transferred in albumin liquid by MARS dialysis membranes, through protein liquid
Purifying regeneration recycles, and sequentially passes through dialysis, resin and activated carbon adsorption and is purified, purified albumin liquid can repeat again
It recycles；Absorber absorption, which reaches saturation postalbumin, cannot reuse and abandon.MARS is due to using albumin transhipment poison
Indirect attachment toxin that is plain and realizing absorber, and influenced by dialysis membrane exchange of toxins efficiency, it removes toxin efficiency and is not so good as blood
Slurry absorption, due to not having supplement blood plasma, cannot improve the coagulation function and Hypoproteinemia of hepatic failure patients, be unsuitable for late period liver
Failure patients.And MARS treatments consumption abandons a large amount of albumin every time, is not easy to be widely used at home.But it passes through resin, work
Property charcoal absorption and synchronize carry out dialysis purification scheme be worth use for reference.As can by plasma exchange, plasma adsorption and dialysis and/or filter
It crosses and is combined, can not only remove protein binding toxin and soluble toxins, supplement albumin and coagulation factor comprehensively, but also can be fully
It is fed back using self again after discarded plasma purification, the dosage of clinical blood can be greatly reduced in this way, and can fully meet liver and decline
Exhaust the state of an illness needs of patient, the more sufferers of effective treatment.
Plasma exchange needs to draw the part blood of patient from internal, passes through centrifugal or membrane type separated plasma side
Method isolates the blood plasma containing a large amount of toxin and gives discarding, while supplementing fresh plasma.Membrane type separated plasma method is to traffic requirement of taking a blood sample
Bigger, up to 100 ~ 120 ml/min, heparin dosage is larger in art, and the very poor middle and advanced stage hepatic failure of coagulation function is suffered from
Person has the risk for leading to bleeding and hemotoncus；Haemodialysis, blood filtering blood sampling flow be up to 200 ~ 350 ml/min, this
Three kinds of treatments are required to carry out deep venouspuncture or arteriopuncture.The art that hepatic failure patients deep venouspuncture or arteriopuncture cause
Middle postoperative complications are more, and risk is big, once bleeding or hemotoncus occurs, seriously affect successive treatment, poor prognosis.Centrifugal separation
Plasma exchange blood sampling flow only needs 30 ~ 60 ml/min, is not necessarily to deep venouspuncture, and Superficial veins puncture in periphery can meet treatment
Blood flow velocity need, and heparin dosage is relatively small, causes the risk of bleeding small；Protein binding toxin can be removed and mended
The bioactive substances such as coagulation factor and albumin are filled, patient's treatment of coagulation function difference is suitable for.But simple plasma exchange
Each toxoid cannot be removed comprehensively, it is especially limited to soluble toxins Scavenging activity, also have to serious hepatic failure patients and induces liver
The risk of stupor, and Clinical practice is limited by blood plasma insufficient supply, therefore serious hepatic failure patients need to be filtered with plasma dialysis
And plasma adsorption combination therapy, protein binding toxin and soluble toxins can be removed to the maximum extent.In order to improve blood plasma filter
The blood plasma that centrifugal plasma displacement instrument detaches need to be raised speed from 25 ~ 30 ml/min, make it with 150 by the efficiency crossed and adsorbed
The flow velocity high speed of ~ 180 ml/min passes through blood filter and two plasorbers（Different classes of toxin is adsorbed respectively）, then
Patient's body is fed back with the speed of 25 ~ 30 ml/min again.
Document number is that the Chinese patent literature of CN203280813U discloses a kind of plasma exchange absorption being equipped with slurry storing bag
Purification system is filtered, which combines plasma exchange, plasma adsorption with plasma dialysis, first carries out 1 hour plasma exchange,
Blood plasma high-speed circulating absorption in 5 hours and plasma dialysis are carried out followed by by specially designed slurry storing bag, but it constitutes complexity, and
It can only be run on the basis of membranous type blood plasma detaches, need deep venouspuncture, Operative risk is big, is unsuitable for coagulation function very poor evening
Phase hepatic failure patients.
Document number is that the Chinese patent literature of CN205073379U discloses one kind by using specially designed blood plasma point
Stream and replacement piping, displacement and adsorbed plasma converge pipeline, and the normal blood purification instrument for possessing 4 pumps using only one can be same
Step completes the purification system and its application process of slow type plasma exchange, plasma adsorption and filtration.But it also can only be in membranous type blood plasma
It is run on the basis of separation, is unsuitable for the very poor late period hepatic failure patients of coagulation function.And blood plasma speed when plasma adsorption and filtration
Degree is 25 ~ 30ml/min, insufficient to the Scavenging activity of soluble toxins.
Invention content
The technical problem to be solved by the present invention is to overcome the deficiencies in the prior art, provides and a kind of set using centrifugal separation plasma
It changes, in combination with the plasma purification system of plasma dialysis accepted filtered absorption, which can give full play in an artificial liver in treatment
Centrifugal plasma is replaced, plasma dialysis filters, the advantage of the dual adsorbing therapy of blood plasma, and meets centrifugal plasma displacement, blood plasma
Dialysis filtration and plasma adsorption to the different demands of plasma flow rate, function more comprehensively, the scope of application it is wider.
In order to solve the above technical problems, the present invention uses following technical scheme：
A kind of Almightiness type plasma purification system based on centrifugal separation plasma method, including plasmapheresis device and plasma dialysis filtration
Adsorbent equipment, the plasmapheresis device include centrifugal plasma separator, and the plasma purification system further includes for collecting
Blood plasma after separation or the blood plasma transfer device for recycling purified blood plasma, the blood plasma transfer device include that blood plasma turns
Bag and useless slurry bag are moved, blood plasma transfer pipe is equipped between the blood plasma output end of the plasmapheresis device and the blood plasma transfering bag
Road is equipped with blood plasma discharge line between the blood plasma transfering bag and the useless slurry bag, the plasma dialysis accepted filtered absorption device
Plasma circulation pipeline is equipped between output end and the blood plasma discharge line.
As a further improvement of the above technical scheme：
The height of the blood plasma transfering bag and the connector of the blood plasma transfer conduit will be less than blood plasma transfering bag and the blood plasma
The height of the connector of discharge line.
The input terminal of the centrifugal plasma separator is connected with the blood sampling pipe for acquiring blood samples of patients, the centrifugation
The output end of formula plasma separator is connected with haemocyte output pipe and plasma outlet tube road, the plasma outlet tube road with it is described
Blood plasma transfer conduit is connected, the input terminal phase of the output end on the plasma outlet tube road and the plasma dialysis accepted filtered absorption device
Even, the plasmapheresis device further includes for the blood plasma recirculation line of autoplamotherapy and for will defeated time trouble of treated blood
The output end of blood back pipeline in person's body, the haemocyte output pipe and the blood plasma recirculation line with the blood back pipeline
Input terminal be connected, the input terminal of the blood plasma recirculation line is connected with the output end of the plasma dialysis accepted filtered absorption device,
The input terminal of the blood plasma recirculation line is connected with the fresh plasma pipeline for supplementing fresh plasma.
The plasma dialysis accepted filtered absorption device includes filtered solution intake line, for carrying out dialysis filtration absorption to blood plasma
Plasma dialysis accepted filtered absorption pipeline and for by the plasma circulation recirculation line of purified plasma circulation or feedback, the blood
The input terminal of slurry dialysis filtration absorption pipeline is connected with the output end on the plasma outlet tube road, the plasma dialysis accepted filtered absorption
The output end of pipeline and the filtered solution intake line is connected with the input terminal of the plasma circulation recirculation line, the blood plasma
The output end of cycle recirculation line is connected with the input terminal of the blood plasma recirculation line and the plasma circulation pipeline respectively.
Blood filter, the first plasorber and the second plasma adsorption are equipped on the plasma dialysis accepted filtered absorption pipeline successively
The lower part side opening of device, the blood filter is connected with dialyzate intake line, and the top side opening of the blood filter is connected with dialyzate
Discharge line.
The plasma circulation pipeline is equipped with the first connectivity port that can be connected to or disconnect, the plasma outlet tube road
The second connection end mouth that can be connected to or disconnect, the plasma circulation are equipped between the plasma dialysis accepted filtered absorption pipeline
The third connectivity port that can be connected to or disconnect, first connection are equipped between recirculation line and the blood plasma recirculation line
The both sides of port, second connection end mouth and third connectivity port are equipped with pipe clamp.
The blood sampling pipe is equipped with blood sampling and pumps, and the speed of the blood sampling pump is 50~60ml/min, the blood plasma output
Pipeline is equipped with blood plasma separation pump, and the speed of the blood plasma separation pump is 25~30ml/min, is set on the blood plasma recirculation line
There is blood plasma front pump, the speed of the blood plasma front pump is 25~30ml/min, is set on the plasma dialysis accepted filtered absorption pipeline
There is plasma circulation transfer tube, the speed of the plasma circulation transfer tube is 150~180ml/min, the dialyzate intake line
It is equipped with dialysis liquid pump, the speed of the dialysis liquid pump is 50~60 ml/min, and the dialyzate discharge line is equipped with waste liquid
The speed of pump, the waste drains pump is 100~120 ml/min, and the filtered solution intake line is equipped with filtrate pump, the filtrate
The speed of pump is 50~60 ml/min.
The blood sampling pipe is equipped with the first liquid pot and the first liquid level for detecting the first liquid pot liquid level is examined
Sensor is surveyed, the plasma dialysis accepted filtered absorption pipeline is equipped with the second liquid pot and for detecting the second liquid pot liquid level
The second level detection sensors device, blood return tube road is equipped with third liquid pot and for detecting the third liquid pot liquid level
Third level detection sensors device, the filtered solution intake line is equipped with the 4th liquid pot and for detecting the 4th liquid pot liquid
4th level detection sensors device of face height, the blood plasma recirculation line are equipped with the 5th liquid pot and for detecting the 5th liquid
5th level detection sensors device of pot liquid level.
It is equipped with pressure detecting connecting tube on the first liquid pot, the second liquid pot and third liquid pot.
It is respectively connected with heparin pump on the first liquid pot and the second liquid pot.
The blood plasma recirculation line is equipped with the first heating component, and the plasma circulation recirculation line is fed back with the blood plasma
One end of piping connection is equipped with the second heating component.
The input terminal of the fresh plasma pipeline is equipped with fresh plasma bag, and the input terminal of the dialyzate intake line is equipped with
The output end of dialyzate bag, the dialyzate discharge line is equipped with waste fluid bag, and the input terminal of the filtered solution intake line is equipped with
Filtrate bag is equipped with extension scale for monitoring weight on the dialyzate bag, waste fluid bag and filtrate bag.
The plasmapheresis device is connected with the computer control system of plasmapheresis device described in independent control, the blood
Slurry dialysis filtration adsorbent equipment is connected with the computer control system of plasma dialysis accepted filtered absorption device described in independent control.
Compared with the prior art, the advantages of the present invention are as follows：
The Almightiness type plasma purification system based on centrifugal separation plasma method of the present invention, including plasmapheresis device, plasma dialysis
Accepted filtered absorption device and blood plasma transfer device, plasmapheresis device are successfully incited somebody to action using centrifugal plasma separator, the present invention
Centrifugal plasma isolation technics and membrane type blood purification technology（Dialysis filtration adsorbs）Combine, combines above two technology
The advantages of, the deficiency of above two technology is overcome, by centrifugal process separated plasma, the requirement to flow of taking a blood sample is small, does not need
Treatment need can be met using deep venouspuncture, improve the safety for the treatment of so that artificial liver in treatment can be extended to solidifying
The very poor middle and advanced stage hepatic failure patients of blood function；Partial cleansing rear blood plasma is recycled by blood plasma transfer device, is solved
Contradiction between high plasma flow rate needed for the low speed separated plasma and plasma dialysis accepted filtered absorption device of centrifugal plasma separator,
So that the discarded blood plasma isolated is carried out the circularly purifying of high speed dialysis, filtration and absorption, gives full play to various purification means
Treatment advantage.Blood plasma transfering bag can play temporary discarded blood plasma, will be Partial cleansing after plasma circulation transfer ease up punching press
The effect of power.Centrifugal plasma displacement and plasma dialysis filtration, the combination therapy of plasma adsorption may be implemented in the present invention, is lacking
Blood plasma or when need not carry out plasma exchange, plasma dialysis filtration and adsorbing therapy are carried out using this system to separated plasma,
It has expanded the artificial liver in treatment pattern of centrifugal plasma partition method, has realized to the comprehensive clear of protein binding toxin and soluble toxins
It removes, on the basis of its existing safety, expands out more fully plasma purification function.
Description of the drawings
Fig. 1 is the structural schematic diagram of the Almightiness type plasma purification system of the present embodiment.
Fig. 2 is that the Almightiness type plasma purification system of the present embodiment carries out the schematic diagram of plasma exchange.
Fig. 3 is that the Almightiness type plasma purification system of the present embodiment carries out the schematic diagram of plasma dialysis accepted filtered absorption.
Marginal data：
1, plasmapheresis device；11, centrifugal plasma separator；12, blood sampling pipe；121, blood sampling pump；122, the first liquid pot；
123, the first level detection sensors device；13, haemocyte output pipe；14, plasma outlet tube road；141, blood plasma separation pump；142、
Second connection end mouth；15, blood plasma recirculation line；151, blood plasma front pump；152, the 5th liquid pot；153, the 5th level detection sensors
Device；154, the first heating component；16, blood back pipeline；161, third liquid pot；162, third level detection sensors device；17, fresh blood
Starch pipeline；171, fresh plasma bag；2, plasma dialysis accepted filtered absorption device；21, filtered solution intake line；211, filtrate pump；
212, the 4th liquid pot；213, the 4th level detection sensors device；214, filtrate bag；22, plasma dialysis accepted filtered absorption pipeline；221, blood
Slurry cycle transfer tube；222, the second liquid pot；223, the second level detection sensors device；224, dialyzate intake line；2241, it dialyses
Liquid pump；2242, dialyzate bag；225, dialyzate discharge line；2251, waste drains pump；2252, waste fluid bag；226, blood filter；227、
First plasorber；228, the second plasorber；23, plasma circulation recirculation line；231, third connectivity port；232,
Two heating components；3, blood plasma transfer device；31, blood plasma transfering bag；32, useless slurry bag；33, blood plasma transfer conduit；34, blood plasma is discharged
Pipeline；35, plasma circulation pipeline；351, the first connectivity port；4, pipe clamp；5, pressure detecting connecting tube；6, heparin pump.
Specific implementation mode
The present invention is described in further details below with reference to Figure of description and specific embodiment.
As shown in Figure 1, the Almightiness type plasma purification system based on centrifugal separation plasma method of the present embodiment, including blood plasma are set
Changing device 1 and plasma dialysis accepted filtered absorption device 2, plasmapheresis device 1 include centrifugal plasma separator 11, plasma purification system
System further includes the blood plasma transfer device 3 for collecting the blood plasma after detaching or recycling purified blood plasma, blood plasma transfer
Device 3 includes blood plasma transfering bag 31 and useless slurry bag 32, is set between the blood plasma output end and blood plasma transfering bag 31 of plasmapheresis device 1
There is blood plasma transfer conduit 33, blood plasma discharge line 34 is equipped between blood plasma transfering bag 31 and useless slurry bag 32, plasma dialysis filtration is inhaled
It is equipped with plasma circulation pipeline 35 between the output end and blood plasma discharge line 34 of adsorption device 2, is equipped in the inlet of useless slurry bag 32
Pipe clamp 4.The plasma purification system includes three parts：Centrifugal plasmapheresis device 1, plasma dialysis accepted filtered absorption device 2
With the blood plasma transfer device 3 for playing the role of connecting the device of front two, centrifugal plasma exchange blood sampling flow is small, treatment safety
Property it is high, be suitable for middle and advanced stage hepatic failure patients, plasma dialysis accepted filtered absorption can remove to the maximum extent protein binding toxin and
Soluble toxins, but need higher plasma flow rate, blood plasma transfer device 3 pass through the plasma circulation after will be Partial cleansing to blood plasma
Dialysis filtration adsorbent equipment 2 is to meet the needs of its high plasmaflux, while repeatedly circulating plasma purifies more thorough, therefore
Success combines centrifugation plasma exchange and plasma dialysis accepted filtered absorption, gives full play to respective treatment advantage, therapeutic effect
More preferably.
In the present embodiment, blood plasma transfering bag 31 and the height of the connector of blood plasma transfer conduit 33 will be less than blood plasma transfering bag
31 with the height of the connector of blood plasma discharge line 34, setting in this way is in only progress plasma exchange, the toxin first separated
The higher blood plasma of concentration constantly drains into useless slurry bag 32 under the promotion for subsequently entering bag blood plasma, and blood plasma is stayed in after the completion of plasma exchange
It is the lower blood plasma containing toxin concentration finally entered in bag in transfering bag 31, it is relatively easy to purify；In addition it is being replaced
, can be by part plasma circulation when adsorbing combination therapy with dialysis filtration, the connector of blood plasma transfer conduit 33 is relatively low can be to avoid
Air enters plasma dialysis accepted filtered absorption device 2 in blood plasma transfering bag 31 when cycle, while can also make in blood plasma transfering bag 31
Remaining discarded blood plasma is introduced into plasma dialysis accepted filtered absorption device 2 and is purified, and reenters blood plasma transfering bag after purifying
31 blood plasma also enters plasma dialysis accepted filtered absorption device 2 and carries out circularly purifying therewith.Blood plasma transfering bag 31 is in addition to that can shift
Blood plasma since its volume can be according to change in pressure in plasma circulation pipeline 35, therefore also plays a part of pressure release bag and avoids
Pressure is excessive in plasma circulation pipeline 35, and the liquid level of observation blood plasma transfering bag 31 can be additionally used in liquid flow in understanding into output
The dynamic equilibrium of amount.
In the present embodiment, the input terminal of centrifugal plasma separator 11 is connected with the blood sampling pipe for acquiring blood samples of patients
12, the output end of centrifugal plasma separator 11 is connected with haemocyte output pipe 13 and plasma outlet tube road 14, blood plasma output
Pipeline 14 is connected with blood plasma transfer conduit 33, and the output end on plasma outlet tube road 14 is defeated with plasma dialysis accepted filtered absorption device 2
Enter end to be connected, plasmapheresis device 1 further includes for the blood plasma recirculation line 15 of autoplamotherapy and for will treated blood
The output end of the blood back pipeline 16 of defeated time patient's body, haemocyte output pipe 13 and blood plasma recirculation line 15 with blood back pipeline
16 input terminal is connected, and the input terminal of blood plasma recirculation line 15 is connected with the output end of plasma dialysis accepted filtered absorption device 2, blood plasma
The input terminal of recirculation line 15 is connected with the fresh plasma pipeline 17 for supplementing fresh plasma.Blood sampling pipe 12 take a blood sample after send to
Centrifugal plasma separator 11, the haemocyte after separation, which is sent by haemocyte output pipe 13 to blood back pipeline 16, to be finally transmitted back to
Human body, the blood plasma after separation are flowed out from plasma outlet tube road 14, and useless slurry bag 32 can be entered by blood plasma transfer conduit 33, also optional
It selects and is sent into 2 progress purified treatment of plasma dialysis accepted filtered absorption device, purified blood plasma is entered back by blood plasma recirculation line 15
Blood vessel road 16 is finally transmitted back to human body, when only carrying out plasma exchange, can supplement fresh plasma by fresh plasma pipeline 17.
In the present embodiment, plasma dialysis accepted filtered absorption device 2 includes filtered solution intake line 21, for being carried out thoroughly to blood plasma
Analyse the plasma dialysis accepted filtered absorption pipeline 22 of accepted filtered absorption and for returning the plasma circulation of purified plasma circulation or feedback
The input terminal of defeated pipeline 23, plasma dialysis accepted filtered absorption pipeline 22 is connected with the output end on plasma outlet tube road 14, plasma dialysis
The output end of accepted filtered absorption pipeline 22 and filtered solution intake line 21 is connected with the input terminal of plasma circulation recirculation line 23, blood
The output end of slurry cycle recirculation line 23 is connected with the input terminal of blood plasma recirculation line 15 and plasma circulation pipeline 35 respectively.Blood plasma
Dialysis filtration absorption pipeline 22 receives the blood plasma from plasma outlet tube road 14 and the purified treatments such as is dialysed, filtered and adsorbed,
Treated, and blood plasma is flowed out from plasma circulation recirculation line 23, and a part enters blood plasma recirculation line 15, and another part enters blood
Slurry recirculation line 15 is recycled, to meet the needs of dialysis filtration adsorption process high flow capacity.
In the present embodiment, blood filter 226, the first plasorber are equipped on plasma dialysis accepted filtered absorption pipeline 22 successively
227 and second plasorber 228, the lower part side opening of blood filter 226 be connected with dialyzate intake line 224, blood filter 226
Top side opening is connected with dialyzate discharge line 225.Specifically, the first plasorber 227 is bilirubin adsorption device, the second blood
Slurry absorber 228 is resin activity charcoal absorber.Blood filter 226, bilirubin adsorption device and resin activity charcoal absorber can be right
Blood plasma carries out effective dialysis filtration suction-operated, removes the toxin in blood plasma, and dialyzate intake line 224 carries for dialysis procedure
For dialyzate, dialyzate discharge line 225 can recycle used dialyzate.
In the present embodiment, plasma circulation pipeline 35 is equipped with the first connectivity port 351 that can be connected to or disconnect, blood plasma
The second connection end mouth 142 that can be connected to or disconnect is equipped between output pipe 14 and plasma dialysis accepted filtered absorption pipeline 22,
The third connectivity port 231 that can be connected to or disconnect is equipped between plasma circulation recirculation line 23 and blood plasma recirculation line 15,
The both sides of first connectivity port 351, second connection end mouth 142 and third connectivity port 231 are equipped with pipe clamp 4.Three connecting pins
Mouth can these three parts be connected into one with blood plasma transfer device 3 by plasmapheresis device 1, plasma dialysis accepted filtered absorption device 2
A complete Almightiness type plasma purification system is operated, while they can also be disconnected to exclusive use, is such as divided into centrifugal
Plasma exchange and membrane type blood purification（Including a variety of therapeutic modalities such as plasma exchange, plasma adsorption, hemodiafiltration）
Two relatively independent systems, while being the artificial liver in treatment of different patient's progress different modes, there is flexibility and more work(
It can property.
In the present embodiment, blood sampling pipe 12 is equipped with blood sampling pump 121, and the speed of blood sampling pump 121 is 50~60ml/min, blood
It starches output pipe 14 and is equipped with blood plasma separation pump 141, the speed of blood plasma separation pump 141 is 25~30ml/min, and blood plasma feeds back pipe
Road 15 is equipped with blood plasma front pump 151, and the speed of blood plasma front pump 151 is 25~30ml/min, plasma dialysis accepted filtered absorption pipe
Road 22 is equipped with plasma circulation transfer tube 221, and the speed of plasma circulation transfer tube 221 is 150~180ml/min, and dialyzate is defeated
Enter pipeline 224 and be equipped with dialysis liquid pump 2241, the speed of dialysis liquid pump 2241 is 50~60 ml/min, dialyzate discharge line
225 are equipped with waste drains pump 2251, and the speed of waste drains pump 2251 is 100~120 ml/min, and filtered solution intake line 21 is equipped with
The speed of filtrate pump 211, filtrate pump 211 is 50~60 ml/min.Blood plasma separation pump 141, blood plasma front pump are adjusted by linkage
151, the speed of filtrate pump 211 and waste drains pump 2251 can carry out fluid balance regulation and control, and then realize ultrafiltration.Specifically, setting
The speed of blood sampling pump 121 is 60ml/min, and the speed of blood plasma separation pump 141 is 30ml/min, and the speed of blood plasma front pump 151 is
The speed of 25ml/min, plasma circulation transfer tube 221 are 180ml/min, and the speed of dialysis liquid pump 2241 is 50ml/min, waste liquid
The speed of pump 2251 is 115 ml/min, and the speed of filtrate pump 211 is 60ml/min, and it is 5ml/min that speed may be implemented at this time
（300ml/h）Ultrafiltration.
In the present embodiment, blood sampling pipe 12 is equipped with the first liquid pot 122 and for detecting 122 liquid level of the first liquid pot
First level detection sensors device 123, plasma dialysis accepted filtered absorption pipeline 22 are equipped with the second liquid pot 222 and for detecting the second liquid
Second level detection sensors device 223 of 222 liquid level of pot, blood back pipeline 16 are equipped with third liquid pot 161 and for detecting the
The third level detection sensors device 162 of three liquid pots, 161 liquid level, filtered solution intake line 21 are equipped with 212 He of the 4th liquid pot
The 4th level detection sensors device 213 for detecting 212 liquid level of the 4th liquid pot, blood plasma recirculation line 15 are equipped with the 5th liquid
Pot 152 and the 5th level detection sensors device 153 for detecting 152 liquid level of the 5th liquid pot, liquid pot can keep in liquid, liquid
Face detection sensor can detect the height of liquid level in liquid pot, ensure the normal operation of system.
In the present embodiment, pressure detecting connecting tube is equipped on the first liquid pot 122, the second liquid pot 222 and third liquid pot 161
5, pressure detecting connecting tube 5 is conducive to system normal operation convenient for the pressure condition in signal piping.
In the present embodiment, heparin pump 6 is respectively connected on the first liquid pot 122 and the second liquid pot 222.
In the present embodiment, blood plasma recirculation line 15 is equipped with the first heating component 154, plasma circulation recirculation line 23 and blood
It starches one end that recirculation line 15 connects and is equipped with the second heating component 232.Liquid in pipeline can be heated to normally by heating component
Physiological temp ensures the balance and stability of patient temperature in therapeutic process.
In the present embodiment, the input terminal of fresh plasma pipeline 17 is equipped with fresh plasma bag 171, dialyzate intake line 224
Input terminal be equipped with dialyzate bag 2242, the output end of dialyzate discharge line 225 is equipped with waste fluid bag 2252, filtered solution input pipe
The input terminal on road 21 is equipped with filtrate bag 214, is equipped on dialyzate bag 2242, waste fluid bag 2252 and filtrate bag 214 for monitoring
The extension scale of weight, to filtrate bag 214, the weight of dialyzate bag 2242, waste fluid bag 2252 and filtrate bag 214 is monitored, so as to
It is replaced in time when surplus deficiency in bag, in order to avoid influence treatment.
In the present embodiment, plasmapheresis device 1 is connected with the computer control system of independent control plasmapheresis device 1,
Plasma dialysis accepted filtered absorption device 2 is connected with the computer control system of independent control plasma dialysis accepted filtered absorption device 2.Specifically
, computer control system can simultaneously be independently controlled from each other in a computer, can also distinguish in 2 computers
Independently controlled.When carrying out the treatment of Almightiness type plasma purification, two computer control systems can also connect collaboration work each other
Make, the connection of pipeline is combined through the invention carries out centrifugation plasma exchange and the treatment of plasma dialysis accepted filtered absorption to an example patient.
Computer control system is separately provided to facilitate the respectively exclusive use of plasmapheresis device 1 and plasma dialysis accepted filtered absorption device 2,
Separately become 2 independent treatment systems, centrifugal separated plasma displacement and membrane type blood plasma are carried out to 2 different patients respectively
Purification treatment, a machine double-purpose, two sets of independent computer control systems according to actual conditions can independent monitoring work, mutual not shadow
It rings, the flexibility and versatility that the system of improving uses.
The application method of the Almightiness type plasma purification system based on centrifugal separation plasma method of the present embodiment is as follows：
（1）Centrifugal separated plasma displacement and the Almightiness type plasma purification treatment of plasma dialysis accepted filtered absorption：
Connect as shown in Fig. 2, disconnecting the first connectivity port 351, second connection end mouth 142 and third connectivity port 231 before treatment
It connects, using heparin-saline respectively to plasmapheresis device 1 and plasma dialysis accepted filtered absorption device 2 under computer program control
Carry out pipeline preliminary filling.
Centrifugal plasma displacement is carried out by centrifugal plasma separator 11 first, and is connected to fresh plasma pipeline 17, newly
Blood is starched under the driving of blood plasma front pump 151 through blood plasma recirculation line 15, and thin with the blood in haemocyte output pipe 13
Born of the same parents through blood back pipeline 16 are fed back to patient's body after converging, and the blood plasma isolated is flowed out from plasma outlet tube road 14, by blood plasma
Transfer conduit 33 enters blood plasma transfering bag 31, then enters useless slurry bag 32 by blood plasma discharge line 34.
As shown in figure 3, after the completion of plasma exchange, the pipe clamp 4 and blood plasma discharge line 34 of closing fresh plasma pipeline 17 lean on
Pipe clamp 4 at nearly useless slurry bag 32, the first connectivity port 351, second connection end mouth 142 are connected to third connectivity port 231, opened
Begin to carry out plasma dialysis accepted filtered absorption treatment：The blood plasma of 11 low speed of centrifugal plasma separator separation is flowed from plasma outlet tube road 14
Go out to enter plasma dialysis accepted filtered absorption pipeline 22, while the blood plasma retained in blood plasma transfering bag 31 passes through blood plasma transfer conduit 33
Into plasma dialysis accepted filtered absorption pipeline 22, these blood plasma are defeated under the action of the plasma circulation transfer tube 221 to run at high speed
It is sent in blood filter 226, bilirubin adsorption device and resin activity charcoal absorber and carries out plasma dialysis filtration and absorption, it is purified
A part of blood plasma feeds back patient's body after converging by blood plasma front pump 151 and haemocyte, and another part blood plasma is followed by blood plasma
Endless tube road 35 enters blood plasma transfering bag 31, and the blood plasma detached with 11 low speed of centrifugal plasma separator converges, by plasma circulation
Transfer tube 221 is transported in plasma dialysis accepted filtered absorption pipeline 22 and carries out circularly purifying, is realized in this way by blood plasma transfer device 3
To the circularly purifying of blood plasma, differentiation requirement of the blood plasma separation with plasma dialysis filtration, plasma adsorption to plasma flow rate can be met,
Solve the low speed separated plasma of centrifugal plasma separator 11 and high plasma flow rate needed for plasma dialysis accepted filtered absorption device 2 it
Between contradiction, be able to the discarded blood plasma of separation carry out cycle high speed dialysis filtration, adsorption cleaning, give full play to various purifications
The treatment advantage of means.
（2）Centrifugal separated plasma displacement is treated respectively with membrane type blood purification：
Since plasmapheresis device 1 and plasma dialysis accepted filtered absorption device 2 are independent from each other, the first connectivity port 351 of disconnection,
Centrifugal separated plasma exchange system can be obtained after second connection end mouth 142 and third connectivity port 231 and membrane type blood is net
Two independent systems of change system, wherein centrifugal separated plasma exchange system, using three pumps, membrane type blood purification system makes
It is pumped with four, does not interfere with each other, controlled respectively by respective computer control system independently of each other, can be that two patients distinguish simultaneously
Carry out centrifugal separated plasma displacement and membrane type blood purification（Including plasma exchange, plasma adsorption, hemodiafiltration etc.
A variety of therapeutic modalities）, with flexibility and multifunctionality.
Although the present invention has been disclosed as a preferred embodiment, however, it is not intended to limit the invention.It is any to be familiar with ability
The technical staff in domain, without deviating from the scope of the technical scheme of the present invention, all using the technology contents pair of the disclosure above
Technical solution of the present invention makes many possible changes and modifications, or is revised as the equivalent embodiment of equivalent variations.Therefore, every
Without departing from the content of technical solution of the present invention, according to the present invention technical spirit any simple modification made to the above embodiment,
Equivalent variations and modification, all shall fall within the protection scope of the technical scheme of the invention.
Claims (10)
1. a kind of Almightiness type plasma purification system based on centrifugal separation plasma method, including plasmapheresis device（1）It is saturating with blood plasma
Analyse accepted filtered absorption device（2）, it is characterised in that：The plasmapheresis device（1）Including centrifugal plasma separator（11）, described
Plasma purification system further includes the blood plasma transfer device for collecting the blood plasma after detaching or recycling purified blood plasma
（3）, the blood plasma transfer device（3）Including blood plasma transfering bag（31）With useless slurry bag（32）, the plasmapheresis device（1）Blood
Starch output end and the blood plasma transfering bag（31）Between be equipped with blood plasma transfer conduit（33）, the blood plasma transfering bag（31）With it is described
Useless slurry bag（32）Between be equipped with blood plasma discharge line（34）, the plasma dialysis accepted filtered absorption device（2）Output end with it is described
Blood plasma discharge line（34）Between be equipped with plasma circulation pipeline（35）.
2. the Almightiness type plasma purification system according to claim 1 based on centrifugal separation plasma method, it is characterised in that：Institute
State blood plasma transfering bag（31）With the blood plasma transfer conduit（33）The height of connector to be less than blood plasma transfering bag（31）With institute
State blood plasma discharge line（34）Connector height.
3. the Almightiness type plasma purification system according to claim 1 based on centrifugal separation plasma method, it is characterised in that：Institute
State centrifugal plasma separator（11）Input terminal be connected with the blood sampling pipe for acquiring blood samples of patients（12）, described centrifugal
Plasma separator（11）Output end be connected with haemocyte output pipe（13）With plasma outlet tube road（14）, the blood plasma output
Pipeline（14）With the blood plasma transfer conduit（33）It is connected, the plasma outlet tube road（14）Output end and the plasma dialysis
Accepted filtered absorption device（2）Input terminal be connected, the plasmapheresis device（1）It further include the blood plasma feedback pipe for autoplamotherapy
Road（15）With for by the blood back pipeline of treated defeated time patient's body of blood（16）, the haemocyte output pipe（13）With
The blood plasma recirculation line（15）Output end with the blood back pipeline（16）Input terminal be connected, the blood plasma recirculation line
（15）Input terminal and the plasma dialysis accepted filtered absorption device（2）Output end be connected, the blood plasma recirculation line（15）'s
Input terminal is connected with the fresh plasma pipeline for supplementing fresh plasma（17）.
4. the Almightiness type plasma purification system according to claim 3 based on centrifugal separation plasma method, it is characterised in that：Institute
State plasma dialysis accepted filtered absorption device（2）Including filtered solution intake line（21）, for carrying out dialysis filtration absorption to blood plasma
Plasma dialysis accepted filtered absorption pipeline（22）With for by the plasma circulation recirculation line of purified plasma circulation or feedback（23）,
The plasma dialysis accepted filtered absorption pipeline（22）Input terminal and the plasma outlet tube road（14）Output end be connected, the blood
It starches dialysis filtration and adsorbs pipeline（22）With the filtered solution intake line（21）Output end with the plasma circulation feed back manage
Road（23）Input terminal be connected, the plasma circulation recirculation line（23）Output end respectively with the blood plasma recirculation line（15）
With the plasma circulation pipeline（35）Input terminal be connected.
5. the Almightiness type plasma purification system according to claim 4 based on centrifugal separation plasma method, it is characterised in that：Institute
State plasma dialysis accepted filtered absorption pipeline（22）On successively be equipped with blood filter（226）, the first plasorber（227）With the second blood plasma
Absorber（228）, the blood filter（226）Lower part side opening be connected with dialyzate intake line（224）, the blood filter
（226）Top side opening be connected with dialyzate discharge line（225）.
6. the Almightiness type plasma purification system according to claim 4 or 5 based on centrifugal separation plasma method, feature exist
In：The plasma circulation pipeline（35）It is equipped with the first connectivity port that can be connected to or disconnect（351）, the blood plasma output
Pipeline（14）With the plasma dialysis accepted filtered absorption pipeline（22）Between be equipped with the second connection end mouth that can be connected to or disconnect
（142）, the plasma circulation recirculation line（23）With the blood plasma recirculation line（15）Between be equipped with can be connected to or disconnect
Third connectivity port（231）, first connectivity port（351）, second connection end mouth（142）With third connectivity port
（231）Both sides be equipped with pipe clamp（4）.
7. the Almightiness type plasma purification system according to claim 5 based on centrifugal separation plasma method, it is characterised in that：Institute
State blood sampling pipe（12）It is equipped with blood sampling pump（121）, the blood sampling pump（121）Speed be 50 ~ 60ml/min, the blood plasma is defeated
Go out pipeline（14）It is equipped with blood plasma separation pump（141）, the blood plasma separation pump（141）Speed be 25 ~ 30ml/min, the blood
Starch recirculation line（15）It is equipped with blood plasma front pump（151）, the blood plasma front pump（151）Speed be 25 ~ 30ml/min, institute
State plasma dialysis accepted filtered absorption pipeline（22）It is equipped with plasma circulation transfer tube（221）, the plasma circulation transfer tube（221）'s
Speed is 150 ~ 180ml/min, the dialyzate intake line（224）It is equipped with dialysis liquid pump（2241）, the dialysis liquid pump
（2241）Speed be 50 ~ 60 ml/min, the dialyzate discharge line（225）It is equipped with waste drains pump（2251）, the waste liquid
Pump（2251）Speed be 100 ~ 120 ml/min, the filtered solution intake line（21）It is equipped with filtrate pump（211）, the filter
Liquid pump（211）Speed be 50 ~ 60 ml/min.
8. the Almightiness type plasma purification system according to claim 4 or 5 based on centrifugal separation plasma method, feature exist
In：The blood sampling pipe（12）It is equipped with the first liquid pot（122）With for detecting the first liquid pot（122）The of liquid level
One level detection sensors device（123）, the plasma dialysis accepted filtered absorption pipeline（22）It is equipped with the second liquid pot（222）With for examining
Survey the second liquid pot（222）Second level detection sensors device of liquid level（223）, the blood back pipeline（16）It is equipped with the
Three liquid pots（161）With for detecting the third liquid pot（161）The third level detection sensors device of liquid level（162）, described
Filtered solution intake line（21）It is equipped with the 4th liquid pot（212）With for detecting the 4th liquid pot（212）The of liquid level
Four level detection sensors devices（213）, the blood plasma recirculation line（15）It is equipped with the 5th liquid pot（152）With for detecting described
Five liquid pots（152）5th level detection sensors device of liquid level（153）, the first liquid pot（122）, the second liquid pot（222）
With third liquid pot（161）On be equipped with pressure detecting connecting tube（5）, the first liquid pot（122）With the second liquid pot（222）It is upper equal
It is connected with heparin pump（6）.
9. the Almightiness type plasma purification system according to claim 5 based on centrifugal separation plasma method, it is characterised in that：Institute
State blood plasma recirculation line（15）It is equipped with the first heating component（154）, the plasma circulation recirculation line（23）With the blood plasma
Recirculation line（15）One end of connection is equipped with the second heating component（232）, the fresh plasma pipeline（17）Input terminal be equipped with
Fresh plasma bag（171）, the dialyzate intake line（224）Input terminal be equipped with dialyzate bag（2242）, the dialyzate
Discharge line（225）Output end be equipped with waste fluid bag（2252）, the filtered solution intake line（21）Input terminal be equipped with filtrate
Bag（214）, the dialyzate bag（2242）, waste fluid bag（2252）With filtrate bag（214）On be equipped with extension for monitoring weight
Scale.
10. the Almightiness type plasma purification system according to any one of claims 1 to 5 based on centrifugal separation plasma method,
It is characterized in that：The plasmapheresis device（1）It is connected with plasmapheresis device described in independent control（1）Computer control system
System, the plasma dialysis accepted filtered absorption device（2）It is connected with plasma dialysis accepted filtered absorption device described in independent control（2）Calculating
Machine control system.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810129418.0A CN108310503A (en) | 2018-02-08 | 2018-02-08 | A kind of Almightiness type plasma purification system based on centrifugal separation plasma method |
| PCT/CN2018/117822 WO2019153848A1 (en) | 2018-02-08 | 2018-11-28 | Versatile plasma purification system based on centrifugal plasma separation method |
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| CN201810129418.0A CN108310503A (en) | 2018-02-08 | 2018-02-08 | A kind of Almightiness type plasma purification system based on centrifugal separation plasma method |
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| CN109568700A (en) * | 2018-12-06 | 2019-04-05 | 成都创合丰生物科技有限公司 | A kind of blood separation dental unit complete machine |
| WO2019153848A1 (en) * | 2018-02-08 | 2019-08-15 | 中南大学湘雅二医院 | Versatile plasma purification system based on centrifugal plasma separation method |
| CN111905167A (en) * | 2020-07-20 | 2020-11-10 | 连云港市第一人民医院 | Multistage hemodialysis and blood component separation device |
| CN113577424A (en) * | 2021-08-20 | 2021-11-02 | 北京健帆医疗设备有限公司 | Waste liquid discharge method for blood purification apparatus, and storage medium |
| CN113877016A (en) * | 2021-10-12 | 2022-01-04 | 中南大学湘雅二医院 | Lymphocyte separation, stem cell immune regulation and purification and reinfusion system |
| CN114225141A (en) * | 2021-10-29 | 2022-03-25 | 南京国青血液净化科技有限公司 | Adsorption filtration purification system for plasmapheresis treatment |
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