CN201026322Y - Multiple organ functions support system - Google Patents
Multiple organ functions support system Download PDFInfo
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- CN201026322Y CN201026322Y CNU2007201241509U CN200720124150U CN201026322Y CN 201026322 Y CN201026322 Y CN 201026322Y CN U2007201241509 U CNU2007201241509 U CN U2007201241509U CN 200720124150 U CN200720124150 U CN 200720124150U CN 201026322 Y CN201026322 Y CN 201026322Y
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Abstract
The utility model discloses a multiple organ supporting system, consisting of an organism, an external blood circulation loop, a plasma separation and adsorption loop, an albumin circulation loop, a dialysis solution loop, a fluid infusion loop, and an operation control system. The utility model can remove the inflammation media, the endotoxin, and abundant small molecular substance in the body of the patients suffering multiple organ dysfunction syndromes. A lung membrane oxygenator replaces lung to exchange air, which enables the utility model to be suitable for reversible respiratory failure. The utility model can make separation and then make adsorption of the blood plasma in blood, and has obvious effect in removing the substance of inflammation media, cell factors, and the endotoxin. Adopting the albumin circulation and purification treatment, the utility model can fully remove the protein binding toxin and the water-soluble and micromolecule toxin (such as hyperammonemia) in the body of the patients suffering liver failure; the utility model can dehydrate precisely and slowly. Based on the present technique and clinical practice, the utility model has all the supporting functions of lung, heart, kidney, and liver, and the function of removing toxin, thereby having a wide treatment range.
Description
Technical field
This utility model relates to a kind of armarium, breathes the medical multiple organ dysfunction and support system of supporting in particular for removing intravital various toxin of multiple organ failure, MOF patient and refuse and providing.
Background technology
Multiple organ dysfunction syndrome (MODS) is two or more organ reversibility dysfunction and depletion of the infringement sequential generations in back such as severe trauma, infection.The multisystem organ dysfunction is badly damaged in the body when multiple organ dysfunction syndrome (MODS) develops into, and consequently depleted syndrome occurring then is called multiple organ dysfunction syndrome (MOF).The nineties in 20th century, someone has proposed the notion of systemic inflammatory response syndrome (SIRS), and it is by infecting or non-infective agent stimulation of host, triggering the whole body body to inflammatory reaction, produce a large amount of inflammatory mediators, finally cause body and a kind of clinical syndrome that cause out of control inflammatory reaction.The relation of clear and definite at present multiple organ dysfunction syndrome (MODS) and systemic inflammatory response syndrome (SIRS), systemic inflammatory response syndrome (SIRS) is the basis, and multiple organ dysfunction syndrome (MODS) is the most serious result of systemic inflammatory response syndrome (SIRS) development.And multiple organ dysfunction syndrome (MODS) comprises that the carrying out property dynamic process of early stage slight dysfunction to end-stage renal failure, multiple organ dysfunction syndrome (MOF) are serious and the most final final result in this pathological process, have the different irreversibility of degree.
Owing to can produce a large amount of harmful substance retentions such as cytokine, inflammatory mediator and endotoxin in patient's body when multiple organ dysfunction syndrome (MODS) takes place, have only by extracorporeal blood and purify removing, could improve patient's hemodynamics and organ dysfunction, and the hemodiafiltration mode pair cell factor, inflammatory mediator and endotoxic removing commonly used at present are not very thorough.
Multiple organ dysfunction syndrome (MODS) shows as acute respiratory distress syndrome (ARDS) pulmonary, it is owing to severe trauma, shock, pyemia etc. cause, forms the acute respiratory failure of characteristics with dyspnea, intractable hypoxemia, lung compliance attenuating, extensive alveolar atrophy and hyaline membrane.Therapeutic modality at present commonly used is to rely on respirator treatment, but it causes the lungs mechanical damage easily, reversible totally unfavorable to lung failure.
Heart failure in the multiple organ dysfunction syndrome (MODS) is embodied in effective circulating load and descends, and inducement often has that infection, water overload, myocardium poisoning, anoxia, drug influence, electrolyte disturbance etc.General hemofiltration can effectively dewater and correct other biochemical unusual and electrolyte disturbance.
Multiple organ dysfunction syndrome (MODS) is also followed acute liver and kidney failure usually.The toxic metabolite of liver failure is a lot, its pith all with albumin bound, as unconjugated bilirubin, cholic acid, non-water-soluble aminoacid and fatty acid, the important toxin of another part is medium and small molecular weight water soluble material, as blood ammonia, carbamide and creatinine etc.Equally, also exist a large amount of medium and small molecule toxins and moisture to need to remove in the renal failure patient body.
Present extracorporeal blood cleaning equipment treatment pattern both domestic and external is all more single, can only remove medium and small molecule toxin of water solublity and dehydration as artificial kidney equipment, artificial liver can only be removed protein binding toxin and micromolecule toxin, the pair cell factor and inflammatory mediator are not almost removed ability, and plasmapheresis can only be removed part macromole toxin, often feels simply helpless during in the face of a plurality of organ failure of multiple organ dysfunction syndrome (MODS).
The utility model content
Technical problem to be solved in the utility model is to provide a kind of and can effectively removes intravital various toxin of multiple organ failure, MOF patient and refuse and the multiple organ dysfunction and support system of breathing support is provided.
First kind of technical scheme of the present utility model is as follows: a kind of multiple organ dysfunction and support system, comprise main frame, operation control display floater and control circuit, its key is: the blood of human body outlet tube joins with the blood inlet of plasma separator behind the blood pump and the membrane lung oxygenator of connecting, the blood outlet of plasma separator is connected by the blood inlet of flexible pipe for medical purpose with first filter, the blood outlet of this first filter communicates by the import of pipeline with the vein kettle, described vein kettle is fixed on the air monitor, outlet at the vein kettle is connected to the blood of human body input pipe, and on the blood of human body input pipe flow plug is installed; The outer lower interface of the film of plasma separator is connected with the separator carrier pipe, and this separator carrier pipe is communicated with described flexible pipe for medical purpose behind first peristaltic pump and the adsorber of connecting; The film of first filter is gone up interface outward and is connected by the blood inlet of pipeline with second filter, the pipeline that picks out from second filter blood outlet is through second peristaltic pump, and behind connect successively active carbon adsorber and the anion adsorber, be connected with the outer lower interface of the film of described first filter; Arranged outside at described main frame has isosmotic solution bag and heater, wherein the isosmotic solution bag is connected with the import of heater by pipeline, the pipeline that picks out from the outlet of heater is divided into two-way, one the tunnel goes up interface outside the film of the 3rd peristaltic pump and described second filter is connected, and another Lu Jingdi four peristaltic pumps are communicated with described flexible pipe for medical purpose; The outer lower interface of the film of described second filter is connected with sewer pipe, and this sewer pipe joins through the 5th peristaltic pump and waste fluid bag.
Adopt above technical scheme, blood of human body is introduced the membrane lung oxygenator by the blood of human body outlet tube under the effect of blood pump, blood is from flow through successively after the outlet of this membrane lung oxygenator is come out plasma separator, first filter and vein kettle, by the defeated the Huis' body of blood of human body input pipe, form the extracorporeal circulation of blood loop; Plasma separator is isolated the plasma fraction material from blood under the effect of first peristaltic pump, fail in the blood back liquid behind the isolated blood plasma process adsorber adsorption cleaning; The outer albumin solution of the first filter film constantly flows to the film inboard of second filter from the film outside of first filter under the effect of second peristaltic pump, and pass through active carbon adsorber and anion adsorber successively, again flow to outside the film of first filter at last, finish the albumin circulation; Liquid in the isosmotic solution bag contains Na
+, K
+, Ca
2+, Mg
2+, Cl
-, HCO
3 -Plasma, its electrolyte ingredient and concentration and normal plasma are close, and osmotic pressure (be about 280～300m0sm/L) with colloidal osmotic pressure approaching, so be called isosmotic solution.After isosmotic solution heated through heater, a part was mended the blood inlet place of going into first filter as displacement liquid under the effect of the 4th peristaltic pump, form the fluid infusion loop; Another part liquid enters the film outside of second filter under the effect of the 3rd peristaltic pump as dialysis solution, carry out mass exchange and remove the medium and small molecule toxin of a large amount of water solublity with the circulation albumin solution, the waste liquid of generation is discharged in the waste fluid bag under the effect of the 5th peristaltic pump.
This programme is by membrane lung oxygenator of polyphone in the extracorporeal circulation of blood loop, suck by the oxygen of membrane lung oxygenator the outside, and handle is discharged with the carbon dioxide that blood exchange back produces, substitute biological lung and finish gas exchange, reduced the lungs mechanical damage, made lung obtain " rest " and functional rehabilitation.
This programme is isolated plasma fraction in the blood by plasma separator, isolated blood plasma can be removed cytokine, inflammatory mediator and endotoxin etc., the inflammatory reaction when effectively alleviating multiple organ dysfunction syndrome (MODS) by adsorber (as active carbon or resin absorption device).
This programme is at the first filter film outer circulation albumin solution, rely on active carbon adsorber and anion adsorber can effectively remove water-insoluble toxin, simultaneously this solution is carried out dialysis filtration, to remove excessive moisture in medium and small molecule toxin of water solublity and the body, can remove the multiple material of liver, renal failure generation, help homeostasis.
This programme is mended a large amount of displacement liquids simultaneously and is carried out the hemofiltration treatment in blood, can fully remove inflammatory mediator, endotoxin and a large amount of middle small-molecule substances that multiple organ dysfunction syndrome (MODS) produces, can adjust Water-Electrolyte and acid-base balance, remove metabolite.
Heater can make and enter blood or approaching with the temperature and the human body temperature of blood contact liq, has guaranteed the thermal balance in the therapeutic process, and has made the patient feel more comfortable.
Be connected to calparine pipe on the blood of human body outlet tube between above-mentioned blood pump and the membrane lung oxygenator, this calparine pipe is connected with the heparin delivery side of pump.Heparin pump is sustainable filling heparin (anticoagulant) in whole blood purification treatment process, to avoid the extracorporeally circulating blood blood coagulation.
Above-mentioned isosmotic solution bag and waste fluid bag are hung on the hook of first electronic scale and second electronic scale, and this first electronic scale is connected with the interior control circuit of second electronic scale and main frame.The waste liquid amount that the control of second electronic scale is come out from blood, first electronic scale control displacement liquid, dialysis solution enter the amount in the blood, displacement liquid, dialysis solution and the waste liquid amount of the continuous balancing unit time turnover of two electronic scales, make waste liquid amount=displacement liquid+dialysis solution+dehydrating amount, remove toxin and the accurate purpose of dehydration in patient's body to reach.
The film of above-mentioned plasma separator is gone up interface outward and is connected with first pressure monitor by pipeline, be connected to arm on the pipeline that is connected between interface and the second filter blood inlet on outside the first filter film, this arm is connected with second pressure monitor, the import of described vein kettle also is connected with the 3rd pressure monitor by pipeline, and the control circuit of first, second and third pressure monitor is connected with operation control display floater by lead respectively, by operation control display floater display abnormality state.
The film external pressure of first pressure monitor monitoring plasma separator, second pressure monitor is monitored the film external pressure of first filter, the pressure of the 3rd pressure monitor monitoring vein kettle, and the abnormal conditions of pressure everywhere can be shown, so that operator take appropriate measures, thereby guaranteed that therapeutic process is safe and reliable.
Be connected to arm on the above-mentioned sewer pipe, this arm and the 4th pressure monitor join, on the blood of human body outlet tube between described blood pump and the membrane lung oxygenator, be connected to the 5th pressure monitor, the control circuit of the 5th pressure monitor and the 4th pressure monitor is connected with operation control display floater by lead respectively, and by operation control display floater display abnormality state.
The 4th pressure monitor is monitored the film external pressure of second filter, the pressure of the 5th pressure monitor monitoring blood of human body outlet tube inner blood, and the abnormal conditions of pressure everywhere can be shown, so that operator take appropriate measures, with the security reliability of further raising therapeutic process.
Second kind of technical scheme of the present utility model is as follows: a kind of multiple organ dysfunction and support system, comprise main frame, operation control display floater and control circuit, its key is: the blood of human body outlet tube joins with the blood inlet of plasma separator behind the blood pump and the membrane lung oxygenator of connecting, the blood outlet of plasma separator is connected successively by flexible pipe for medical purpose behind second filter and first filter, communicate with the import of vein kettle, described vein kettle is fixed on the air monitor, outlet at the vein kettle is connected to the blood of human body input pipe, and on the blood of human body input pipe flow plug is installed; The outer lower interface of the film of plasma separator is connected with the separator carrier pipe, and this separator carrier pipe is communicated with the flexible pipe for medical purpose in close plasma separator blood exit behind first peristaltic pump and the adsorber of connecting; Outside the film of first filter, go up pipeline that interface picks out through second peristaltic pump, and behind connect successively active carbon adsorber and the anion adsorber, be connected with the outer lower interface of the film of described first filter; Arranged outside at described main frame has isosmotic solution bag and heater, wherein the isosmotic solution bag is connected with the import of heater by pipeline, the pipeline that picks out from the outlet of heater is divided into two-way, one the tunnel goes up interface outside the film of the 3rd peristaltic pump and described second filter is connected, the blood that another Lu Jingdi four peristaltic pumps are connected on described second filter export and the blood inlet of first filter between; The outer lower interface of the film of described second filter is connected with sewer pipe, and this sewer pipe joins through the 5th peristaltic pump and waste fluid bag.
Adopt above technical scheme, blood of human body is introduced the membrane lung oxygenator by the blood of human body outlet tube under the effect of blood pump, blood is from flow through successively after the outlet of this membrane lung oxygenator is come out plasma separator, second filter, first filter and vein kettle, by the defeated the Huis' body of blood of human body input pipe, form the extracorporeal circulation of blood loop; Plasma separator is isolated the plasma fraction material from blood under the effect of first peristaltic pump, fail in the blood back liquid behind the isolated blood plasma process adsorber adsorption cleaning; The outer albumin solution of the first filter film passes through active carbon adsorber and anion adsorber successively under the effect of second peristaltic pump, flow to again outside the film of first filter at last, finishes the albumin circulation; After liquid in the isosmotic solution bag heated through heater, a part was mended the blood inlet place of going into first filter as displacement liquid under the effect of the 4th peristaltic pump, form the fluid infusion loop; Another part liquid enters the film outside of second filter under the effect of the 3rd peristaltic pump as dialysis solution, carry out mass exchange and remove the medium and small molecule toxin of a large amount of water solublity with the circulation albumin solution, the waste liquid of generation is discharged in the waste fluid bag under the effect of the 5th peristaltic pump.
This programme is by membrane lung oxygenator of polyphone in the extracorporeal circulation of blood loop, suck by the oxygen of membrane lung oxygenator the outside, and handle is discharged with the carbon dioxide that blood exchange back produces, substitute biological lung and finish gas exchange, reduced the lungs mechanical damage, made lung obtain " rest " and functional rehabilitation.
This programme is isolated plasma fraction in the blood by plasma separator, isolated blood plasma can be removed cytokine, inflammatory mediator and endotoxin etc., the inflammatory reaction when effectively alleviating multiple organ dysfunction syndrome (MODS) by adsorber (as active carbon or resin absorption device).
This programme is at the first filter film outer circulation albumin solution, rely on active carbon adsorber and anion adsorber can effectively remove water-insoluble toxin, simultaneously this solution is carried out dialysis filtration, to remove excessive moisture in medium and small molecule toxin of water solublity and the body, can remove the multiple material of liver, renal failure generation, help homeostasis.
This programme is mended a large amount of displacement liquids simultaneously and is carried out the hemofiltration treatment in blood, can fully remove inflammatory mediator, endotoxin and a large amount of middle small-molecule substances that multiple organ dysfunction syndrome (MODS) produces, can adjust Water-Electrolyte and acid-base balance, remove metabolite.
Heater can make and enter blood or approaching with the temperature and the human body temperature of blood contact liq, has guaranteed the thermal balance in the therapeutic process, and has made the patient feel more comfortable.
Be connected to calparine pipe on the blood of human body outlet tube between above-mentioned blood pump and the membrane lung oxygenator, this calparine pipe is connected with the heparin delivery side of pump.Heparin pump is sustainable filling heparin (anticoagulant) in whole blood purification treatment process, to avoid the extracorporeally circulating blood blood coagulation.
Above-mentioned isosmotic solution bag and waste fluid bag are hung on the hook of first electronic scale and second electronic scale, and this first electronic scale is connected with the interior control circuit of second electronic scale and main frame.The waste liquid amount that the control of second electronic scale is come out from blood, first electronic scale control displacement liquid, dialysis solution enter the amount in the blood, displacement liquid, dialysis solution and the waste liquid amount of the continuous balancing unit time turnover of two electronic scales, make waste liquid amount=displacement liquid+dialysis solution+dehydrating amount, remove toxin and the accurate purpose of dehydration in patient's body to reach.
The film of above-mentioned plasma separator is gone up interface outward and is connected with first pressure monitor by pipeline, be connected to arm on the pipeline that is connected between interface and second peristaltic pump on outside the first filter film, this arm is connected with second pressure monitor, the import of described vein kettle also is connected with the 3rd pressure monitor by pipeline, and the control circuit of first, second and third pressure monitor is connected with operation control display floater by lead respectively, by operation control display floater display abnormality state.
The film external pressure of first pressure monitor monitoring plasma separator, second pressure monitor is monitored the film external pressure of first filter, the pressure of the 3rd pressure monitor monitoring vein kettle, and the abnormal conditions of pressure everywhere can be shown, so that operator take appropriate measures, thereby guaranteed that therapeutic process is safe and reliable.
Be connected to arm on the above-mentioned sewer pipe, this arm and the 4th pressure monitor join, on the blood of human body outlet tube between described blood pump and the membrane lung oxygenator, be connected to the 5th pressure monitor, the control circuit of the 5th pressure monitor and the 4th pressure monitor is connected with operation control display floater by lead respectively, and by operation control display floater display abnormality state.
The 4th pressure monitor is monitored the film external pressure of second filter, the pressure of the 5th pressure monitor monitoring blood of human body outlet tube inner blood, and the abnormal conditions of pressure everywhere can be shown, so that operator take appropriate measures, with the security reliability of further raising therapeutic process.
The beneficial effects of the utility model are:
1, the hemodiafiltration treatment can be carried out simultaneously, the intravital inflammatory mediator of multiple organ dysfunction syndrome (MODS) patient, endotoxin and a large amount of middle small-molecule substances can be removed.
2, this utility model adopts the lung membrane oxygenator to introduce oxygen in blood, gets rid of CO2 and replace the gas exchange function of lung, can not produce damage to lung, be applicable to the reversibility respiratory failure.
3, the blood plasma in the blood is separated after again absorption, material effects such as eliminate the inflammation medium, cytokine and endotoxin are obvious.
4, intravital protein binding toxin of liver failure patient and soluble small molecular toxin (as blood ammonia etc.) can be fully removed in albumin circularly purifying treatment.
5, can accurately slowly dewater, it is better that moisture in renal failure in the multiple organ dysfunction syndrome (MODS) or the heart failure body is removed effect, and hemodynamic stability.
6, on the basis of existing science and technology and clinical practice, integrate lung, the heart, kidney, rami hepatici and hold function and remove detoxifying function, therapeutic domain is extensive.
7, the complete machine monitoring function is comprehensive, reliable, the automaticity height, and therapeutic process safety, workable.
Description of drawings
Fig. 1 is the structural representation of this utility model embodiment 1.
Fig. 2 is the structural representation of this utility model embodiment 2.
Among the figure: the 1-main frame; 2-operation control display floater; 3-blood of human body outlet tube; The 4-blood pump; 5-membrane lung oxygenator; The 6-plasma separator; The 7-flexible pipe for medical purpose; 8-first filter; 9-vein kettle; The 10-air monitor; 11-blood of human body input pipe; The 12-flow plug; 13-separator carrier pipe; 14-first peristaltic pump; The 15-adsorber; 16-second filter; 17-second peristaltic pump; The 18-active carbon adsorber; 19-anion adsorber; 20-isosmotic solution bag; The 21-heater; 22-the 3rd peristaltic pump; 23-the 4th peristaltic pump; The 24-sewer pipe; 25-the 5th peristaltic pump; The 26-waste fluid bag; The 27-calparine pipe; The 28-heparin pump; 29-first electronic scale; 30-second electronic scale; 31-first pressure monitor; 32-second pressure monitor; 33-the 3rd pressure monitor; 34-the 4th pressure monitor; 35-the 5th pressure monitor; The 36-support bar; The 37-side lever.
The specific embodiment
The utility model is described in further detail below in conjunction with drawings and Examples:
As shown in Figure 1, multiple organ dysfunction and support system is made up of body, extracorporeal circulation of blood loop, separating plasma absorption loop, albumin closed circuit, dialysis fluid circuit, fluid infusion loop and operation control system in the present embodiment.Body comprises main frame 1, support bar 36 and side lever 37, wherein support bar 36 and side lever 37 separations are in the both sides of main frame 1, on the top of support bar 36 first electronic scale 29 is installed, is hung with isosmotic solution bag 20 on the hook of this first electronic scale 29, the below of isosmotic solution bag 20 is provided with heater 21; Plasma separator 6 is decided by the filter clamping in the bottom of side lever 37, and membrane lung oxygenator 5 is installed below plasma separator 6.The middle part in described main frame 1 front is installed the right side of first filter 8 and second filter, 16, the second filters 16 side by side and by air monitor 10 vein kettle 9 is installed by the filter folder.Below second filter 16, heparin pump 28 is housed, the left side of heparin pump 28 belows is provided with second electronic scale 30, hang with waste fluid bag 26 on the hook of this second electronic scale 30, anion adsorber 19, active carbon adsorber 18 and adsorber 15 are installed side by side on the right side of waste fluid bag 26.
As can be known from Fig. 1, the extracorporeal circulation of blood loop is made up of blood of human body outlet tube 3, blood pump 4, membrane lung oxygenator 5, plasma separator 6, first filter 8, vein kettle 9, air monitor 10, flow plug 12 and blood of human body input pipe 11 etc.Wherein blood of human body outlet tube 3 pile warp blood pumps 4 backs are connected with the inlet of membrane lung oxygenator 5, blood flow in the blood of human body outlet tube 3 provides power by blood pump 4, be connected to calparine pipe 27 on the blood of human body outlet tube 3 between blood pump 4 and the membrane lung oxygenator 5, this calparine pipe 27 is connected with the outlet of heparin pump 28; The liquid outlet of membrane lung oxygenator 5 joins by the blood inlet at pipeline and plasma separator 6 tops, the blood outlet of plasma separator 6 is connected with the blood inlet at first filter, 8 tops by flexible pipe for medical purpose 7, the blood outlet of these first filter, 8 bottoms communicates with the 9 vertical imports of vein kettle by pipeline, outlet at vein kettle 9 is connected to blood of human body input pipe 11, and on the blood of human body input pipe 11 flow plug 12 is installed.
From Fig. 1 also as can be known, separating plasma absorption loop is made up of plasma separator 6, separator carrier pipe 13, first peristaltic pump 14 and adsorber 15 etc., wherein the outer lower interface of the film of plasma separator 6 is connected with separator carrier pipe 13, these separator carrier pipe 13 pile warps first peristaltic pump 14 backs are connected with the inlet at adsorber 15 tops, and flowing of liquid provides power by first peristaltic pump 14 in the separator carrier pipe 13; The liquid outlet of adsorber 15 bottoms is communicated with by the flexible pipe for medical purpose 7 of pipeline with close plasma separator 6 blood exits.
From Fig. 1 also as can be known, the albumin closed circuit is made up of first filter 8, second filter 16, second peristaltic pump 17, active carbon adsorber 18 and anion adsorber 19 etc., wherein the film of first filter 8 is gone up interface outward and is connected by the blood inlet of pipeline with second filter 16, the pipeline pile warp second peristaltic pump 17 back inlets with active carbon adsorber 18 tops that pick out from the outlet of second filter, 16 blood join, and flowing of liquid provides power by second peristaltic pump 17 in this pipeline; The liquid outlet of active carbon adsorber 18 bottoms is connected with the inlet pipeline at anion adsorber 19 tops, and the outer lower interface of the liquid outlet of anion adsorber 19 bottoms and the film of described first filter 8 joins.
From Fig. 1 also as can be known, dialysis fluid circuit is made up of isosmotic solution bag 20, heater 21, the 3rd peristaltic pump 22, second filter 16, the 5th peristaltic pump 25 and waste fluid bag 26, wherein isosmotic solution bag 20 is connected by the import of pipeline with heater 21, the pipeline that picks out from the outlet of heater 21 is divided into two-way, wherein branch road pile warp the 3rd peristaltic pump 22 backs are gone up interface outward with the film of second filter 16 and are connected, and the mobile of liquid provides power by the 3rd peristaltic pump 22 in this branch road; The outer lower interface of the film of second filter 16 is connected with sewer pipe 24, and sewer pipe 24 pile warps the 5th peristaltic pump 25 backs join with waste fluid bag 26, and flowing of waste liquid provides power by the 5th peristaltic pump 25 in the sewer pipe 24.Another branch road pile warp the 4th peristaltic pump 23 backs that pick out from heater 21 outlets are communicated with the flexible pipe for medical purpose 7 of close first filter, 8 blood inlets, constitute the fluid infusion loop.
From Fig. 1, can further find out, the top in main frame 1 front is provided with operation control display floater 2, this operation control display floater 2 is electrically connected with first electronic scale 29, second electronic scale 30, heater 21, flow plug 12, air monitor 10, first pressure monitor 31, second pressure monitor 32, the 3rd pressure monitor 33, the 4th pressure monitor 34 and the 5th pressure monitor 35 respectively by the control circuit in the main frame 1, and the liquid crystal display of controlling on the display floater 2 by operation carries out the state demonstration, the formation operation control system.Wherein first pressure monitor 31 is gone up interface by pipeline outward with the film of plasma separator 6 and is connected, be connected to arm on the pipeline that is connected between interface and second filter, 16 blood inlets on outside first filter, 8 films, this arm is connected with second pressure monitor 32,33 imports by pipeline and vein kettle 8 of the 3rd pressure monitor are joined, on sewer pipe 24, be connected to arm, this arm and the 4th pressure monitor 34 join, and described the 5th pressure monitor 35 is connected on the blood of human body outlet tube 3 between blood pump 4 and the membrane lung oxygenator 5 by pipeline.On operation control display floater 2, be distributed with and each monitor corresponding key switch, can conveniently realize safety monitoring and the real-time monitoring of enforcement the entire machine operation.
In this utility model, independent parts such as blood pump, membrane lung oxygenator, plasma separator, filter, vein kettle, adsorber, heater, electronic scale and monitor are prior art, and its structure and operation principle are not done at this and given unnecessary details.
Work process of the present utility model is as follows:
As shown in Figure 1, human vein blood is introduced membrane lung oxygenator 5 by blood of human body outlet tube 3 under the effect of blood pump 4, blood is introduced the human vein ends by blood of human body input pipe 11 at last and is finished the extracorporeal circulation of blood process from flow through successively after the liquid outlet of this membrane lung oxygenator 5 comes out plasma separator 6, first transfusion filters 8 and vein kettle 9.Air monitor 10 has monitored air can prevent that bubble from entering blood of human body by occlude bloods by flow plug then 12; And continuing to inject heparin in the exit of blood pump 4, heparin pump 28 prevents the extracorporeally circulating blood blood coagulation.Simultaneously, the 5th pressure monitor 35 is the interior blood pressure of monitoring human blood outlet tube at any time, and the 3rd pressure monitor is monitored the pressure of vein kettle at any time, if there are abnormal conditions then can show by operation control display floater 2, so that take appropriate measures, guarantee treatment safety.
First peristaltic pump 14 is constantly isolated the plasma fraction in the blood circulation from plasma separator 6, isolated blood plasma is transported in the adsorber 15 through separator carrier pipe 13, in defeated blood back liquid behind adsorber 15 adsorption cleanings.Simultaneously, first pressure monitor 31 that the outer top sub of plasma separator 6 films connects is monitored the film external pressure of plasma separator 6 at any time, prevents rupture of membranes.This process can be removed a large amount of materials such as cytokine, inflammatory mediator and endotoxin in multiple organ dysfunction syndrome (MODS) the patient body, when adopting special adsorber also can remove some special macromole toxin.
The outer albumin solution of first filter, 8 films constantly flows to the film inboard of second filter 16 from the film outside of first filter 8 under the effect of second peristaltic pump 17, and pass through active carbon adsorber 18 and anion adsorber 19 successively, again flow to outside the film of first filter 8 at last, finish the albumin circulation.Arm outside the film of first transfusion filters 8 on the top sub pipeline is connected with second pressure monitor 32, and this second pressure monitor 32 is monitored the film external pressure of first transfusion filters 8 at any time, prevents rupture of membranes.A large amount of albumin bound toxin that this cyclic process produces in the time of effectively removing multiple organ dysfunction syndrome (MODS) patient liver failure.
After liquid in the isosmotic solution bag 20 heated through heater 21, a part was mended the blood inlet place of going into first filter 8 as displacement liquid under the effect of the 4th peristaltic pump 23, form the fluid infusion loop; Another part liquid enters the film outside of second filter 16 under the effect of the 3rd peristaltic pump 22 as dialysis solution, carry out mass exchange and remove the medium and small molecule toxin of a large amount of water solublity with the circulation albumin solution, the waste liquid of generation is discharged in the waste fluid bag 26 under the effect of the 5th peristaltic pump 25.Be connected with the film external pressure that the 4th pressure monitor 34, the four pressure monitors 34 are monitored second transfusion filters 16 at any time by arm on the pipeline near lower interface outside the film of second filter 16, to prevent rupture of membranes.The waste liquid that lower interface is discharged outside the film of second filter 16 comprises that displacement liquid, dialysis solution and the human body dehydrating amount mending (usually has a large amount of moisture retentions in the cardiorenal failure patient body and can't get rid of, blood relies on the machine dehydration), waste liquid amount=displacement liquid+dialysis solution+human body dehydrating amount, first electronic scale 29 and second electronic scale 30 are just controlled the rotating speed of the 3rd peristaltic pump 22, the 4th peristaltic pump 23 and the 5th peristaltic pump 25 according to this formula, finally reach the turnover fluid balance and accurately dewater from human body.
In Fig. 2, multiple organ dysfunction and support system also is made up of body, extracorporeal circulation of blood loop, separating plasma absorption loop, albumin closed circuit, dialysis fluid circuit, fluid infusion loop and operation control system in the present embodiment.Body comprises main frame 1, support bar 36 and side lever 37, and the layouts of parts on main frame 1 such as strut 36, side lever 37, first electronic scale 29, isosmotic solution bag 20, heater 21, plasma separator 6, membrane lung oxygenator 5, first filter 8, second filter 16, air monitor 10, vein kettle 9, heparin pump 28, second electronic scale 30, waste fluid bag 26, anion adsorber 19, active carbon adsorber 18 and adsorber 15 are with embodiment 1.
As can be known from Fig. 2, the extracorporeal circulation of blood loop is made up of blood of human body outlet tube 3, blood pump 4, membrane lung oxygenator 5, plasma separator 6, second filter 16, first filter 8, vein kettle 9, air monitor 10, flow plug 12 and blood of human body input pipe 11 etc.Wherein blood of human body outlet tube 3 pile warp blood pumps 4 backs are connected with the inlet of membrane lung oxygenator 5, blood flow in the blood of human body outlet tube 3 provides power by blood pump 4, be connected to calparine pipe 27 on the blood of human body outlet tube 3 between blood pump 4 and the membrane lung oxygenator 5, this calparine pipe 27 is connected with the outlet of heparin pump 28; The liquid outlet of membrane lung oxygenator 5 joins by the blood inlet at pipeline and plasma separator 6 tops, the blood outlet of plasma separator 6 is connected with the blood inlet at second filter, 16 tops by flexible pipe for medical purpose 7, the blood outlet of second filter, 16 bottoms communicates by the blood inlet of pipeline with first filter, 8 tops, the blood outlet of these first filter, 8 bottoms communicates with the 9 vertical imports of vein kettle by pipeline, outlet at vein kettle 9 is connected to blood of human body input pipe 11, and on the blood of human body input pipe 11 flow plug 12 is installed.
From Fig. 2 also as can be known, the albumin closed circuit is made up of first filter 8, second peristaltic pump 17, active carbon adsorber 18 and anion adsorber 19 etc., wherein the film of first filter 8 inlets of going up pipeline pile warp second peristaltic pump 17 backs that interface picks out and active carbon adsorber 18 tops outward join, and flowing of liquid provides power by second peristaltic pump 17 in this pipeline; The liquid outlet of active carbon adsorber 18 bottoms is connected with the inlet pipeline at anion adsorber 19 tops, and the outer lower interface of the liquid outlet of anion adsorber 19 bottoms and the film of described first filter 8 joins.
Can find out further that from Fig. 2 separating plasma absorption loop, dialysis fluid circuit, fluid infusion loop, operation control system and operation principle in the present embodiment are identical with embodiment 1, not do at this and give unnecessary details.
Claims (10)
1. a multiple organ dysfunction and support system comprises main frame (1), operation control display floater (2) and control circuit, it is characterized in that:
A, blood of human body outlet tube (3) join with the blood inlet of plasma separator (6) behind the blood pump (4) and the membrane lung oxygenator (5) of connecting, the blood outlet of plasma separator (6) is connected with the blood inlet of first filter (8) by flexible pipe for medical purpose (7), the blood outlet of this first filter (8) communicates by the import of pipeline with vein kettle (9), described vein kettle (9) is fixed on the air monitor (10), outlet at vein kettle (9) is connected to blood of human body input pipe (11), and blood of human body input pipe (11) is gone up installation flow plug (12);
The outer lower interface of the film of B, plasma separator (6) is connected with separator carrier pipe (13), and this separator carrier pipe (13) is communicated with described flexible pipe for medical purpose (7) behind first peristaltic pump (14) and the adsorber of connecting (15);
The film of C, first filter (8) is gone up interface outward and is connected by the blood inlet of pipeline with second filter (16), the pipeline that picks out from second filter (16) blood outlet is through second peristaltic pump (17), and behind connect successively active carbon adsorber (18) and the anion adsorber (19), be connected with the outer lower interface of the film of described first filter (8);
D, isosmotic solution bag (20) and heater (21) are arranged in the arranged outside of described main frame (1), wherein isosmotic solution bag (20) is connected by the import of pipeline with heater (21), the pipeline that picks out from the outlet of heater (21) is divided into two-way, one the tunnel goes up interface outside the film of the 3rd peristaltic pump (22) and described second filter (16) is connected, and another Lu Jingdi four peristaltic pumps (23) are communicated with described flexible pipe for medical purpose (7);
The outer lower interface of the film of E, described second filter (16) is connected with sewer pipe (24), and this sewer pipe (24) joins through the 5th peristaltic pump (25) and waste fluid bag (26).
2. multiple organ dysfunction and support system according to claim 1, it is characterized in that: be connected to calparine pipe (27) on the blood of human body outlet tube (3) between described blood pump (4) and the membrane lung oxygenator (5), this calparine pipe (27) is connected with the outlet of heparin pump (28).
3. multiple organ dysfunction and support system according to claim 1 and 2, it is characterized in that: described isosmotic solution bag (20) and waste fluid bag (26) are hung on the hook of first electronic scale (29) and second electronic scale (30), and this first electronic scale (29) is connected with the interior control circuit of second electronic scale (30) and main frame (1).
4. multiple organ dysfunction and support system according to claim 1, it is characterized in that: the film of described plasma separator (6) is gone up interface outward and is connected with first pressure monitor (31) by pipeline, outside first filter (8) film, go up on the pipeline that is connected between interface and second filter (16) blood inlet and be connected to arm, this arm is connected with second pressure monitor (32), the import of described vein kettle (8) also is connected with the 3rd pressure monitor (33) by pipeline, and first, two, three pressure monitors (31,32,33) control circuit is connected with operation control display floater (2) by lead respectively, by operation control display floater (2) display abnormality state.
5. according to claim 1 or 4 described multiple organ dysfunction and support systems, it is characterized in that: described sewer pipe is connected to arm on (24), this arm and the 4th pressure monitor (34) join, on the blood of human body outlet tube (3) between described blood pump (4) and the membrane lung oxygenator (5), be connected to the 5th pressure monitor (35), the control circuit of the 5th pressure monitor (35) and the 4th pressure monitor (34) is connected with operation control display floater (2) by lead respectively, and by operation control display floater (2) display abnormality state.
6. a multiple organ dysfunction and support system comprises main frame (1), operation control display floater (2) and control circuit, it is characterized in that:
A, blood of human body outlet tube (3) join with the blood inlet of plasma separator (6) behind the blood pump (4) and the membrane lung oxygenator (5) of connecting, the blood outlet of plasma separator (6) is connected successively by flexible pipe for medical purpose (7) behind second filter (16) and first filter (8), communicate with the import of vein kettle (9), described vein kettle (9) is fixed on the air monitor (10), outlet at vein kettle (9) is connected to blood of human body input pipe (11), and blood of human body input pipe (11) is gone up installation flow plug (12);
The outer lower interface of the film of B, plasma separator (6) is connected with separator carrier pipe (13), and this separator carrier pipe (13) is communicated with the flexible pipe for medical purpose (7) in close plasma separator (6) blood exit behind first peristaltic pump (14) and the adsorber of connecting (15);
C, outside the film of first filter (8), go up pipeline that interface picks out, and behind connect successively active carbon adsorber (18) and the anion adsorber (19) through second peristaltic pump (17), with the film of described first filter (8) outward lower interface be connected;
D, isosmotic solution bag (20) and heater (21) are arranged in the arranged outside of described main frame (1), wherein isosmotic solution bag (20) is connected by the import of pipeline with heater (21), the pipeline that picks out from the outlet of heater (21) is divided into two-way, one the tunnel goes up interface outside the film of the 3rd peristaltic pump (22) and described second filter (16) is connected, the blood that another Lu Jingdi four peristaltic pumps (23) are connected on described second filter (16) export and the blood inlet of first filter (8) between;
The outer lower interface of the film of E, described second filter (16) is connected with sewer pipe (24), and this sewer pipe (24) joins through the 5th peristaltic pump (25) and waste fluid bag (26).
7. multiple organ dysfunction and support system according to claim 6, it is characterized in that: be connected to calparine pipe (27) on the blood of human body outlet tube (3) between described blood pump (4) and the membrane lung oxygenator (5), this calparine pipe (27) is connected with the outlet of heparin pump (28).
8. according to claim 6 or 7 described multiple organ dysfunction and support systems, it is characterized in that: described isosmotic solution bag (20) and waste fluid bag (26) are hung on the hook of first electronic scale (29) and second electronic scale (30), and this first electronic scale (29) is connected with the interior control circuit of second electronic scale (30) and main frame (1).
9. multiple organ dysfunction and support system according to claim 6, it is characterized in that: the film of described plasma separator (6) is gone up interface outward and is connected with first pressure monitor (31) by pipeline, outside first filter (8) film, go up on the pipeline that is connected between interface and second peristaltic pump (17) and be connected to arm, this arm is connected with second pressure monitor (32), the import of described vein kettle (8) also is connected with the 3rd pressure monitor (33) by pipeline, and first, two, three pressure monitors (31,32,33) control circuit is connected with operation control display floater (2) by lead respectively, by operation control display floater (2) display abnormality state.
10. according to claim 6 or 9 described multiple organ dysfunction and support systems, it is characterized in that: described sewer pipe is connected to arm on (24), this arm and the 4th pressure monitor (34) join, on the blood of human body outlet tube (3) between described blood pump (4) and the membrane lung oxygenator (5), be connected to the 5th pressure monitor (35), the control circuit of the 5th pressure monitor (35) and the 4th pressure monitor (34) is connected with operation control display floater (2) by lead respectively, and by operation control display floater (2) display abnormality state.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007201241509U CN201026322Y (en) | 2007-04-28 | 2007-04-28 | Multiple organ functions support system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007201241509U CN201026322Y (en) | 2007-04-28 | 2007-04-28 | Multiple organ functions support system |
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| Publication Number | Publication Date |
|---|---|
| CN201026322Y true CN201026322Y (en) | 2008-02-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2007201241509U Expired - Lifetime CN201026322Y (en) | 2007-04-28 | 2007-04-28 | Multiple organ functions support system |
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| CN (1) | CN201026322Y (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100486651C (en) * | 2007-04-27 | 2009-05-13 | 高光勇 | Multiple organ dysfunction support system |
| CN101745158B (en) * | 2008-12-10 | 2013-05-01 | 旭化成医疗株式会社 | System for removing virus and cytokine from blood |
| CN108553703A (en) * | 2018-06-15 | 2018-09-21 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | A kind of ECMO equipment |
| WO2022170937A1 (en) * | 2021-02-09 | 2022-08-18 | 苏州心擎医疗技术有限公司 | Multi-organ extracorporeal life support system |
-
2007
- 2007-04-28 CN CNU2007201241509U patent/CN201026322Y/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100486651C (en) * | 2007-04-27 | 2009-05-13 | 高光勇 | Multiple organ dysfunction support system |
| CN101745158B (en) * | 2008-12-10 | 2013-05-01 | 旭化成医疗株式会社 | System for removing virus and cytokine from blood |
| CN108553703A (en) * | 2018-06-15 | 2018-09-21 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | A kind of ECMO equipment |
| WO2022170937A1 (en) * | 2021-02-09 | 2022-08-18 | 苏州心擎医疗技术有限公司 | Multi-organ extracorporeal life support system |
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